WO2015082376A3 - Use of substituted 2,3-dihydroimidazo[1,2-c] quinazolines for the treatment of cancer - Google Patents

Use of substituted 2,3-dihydroimidazo[1,2-c] quinazolines for the treatment of cancer Download PDF

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Publication number
WO2015082376A3
WO2015082376A3 PCT/EP2014/076051 EP2014076051W WO2015082376A3 WO 2015082376 A3 WO2015082376 A3 WO 2015082376A3 EP 2014076051 W EP2014076051 W EP 2014076051W WO 2015082376 A3 WO2015082376 A3 WO 2015082376A3
Authority
WO
WIPO (PCT)
Prior art keywords
treatment
dihydroimidazo
quinazolines
cancer
substituted
Prior art date
Application number
PCT/EP2014/076051
Other languages
French (fr)
Other versions
WO2015082376A2 (en
Inventor
Liu NINGSHU
Arne Scholz
Andrea HÄGEBARTH
Original Assignee
Bayer Pharma Aktiengesellschaft
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Pharma Aktiengesellschaft filed Critical Bayer Pharma Aktiengesellschaft
Publication of WO2015082376A2 publication Critical patent/WO2015082376A2/en
Publication of WO2015082376A3 publication Critical patent/WO2015082376A3/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Abstract

The present invention relates to 2,3-dihydroimidazo(1,2-c)quinazoline derivatives as inhibitors of P13K kinase for the treatment or prophylaxis of a disease, particularly for the treatment of cancers and their metastases.
PCT/EP2014/076051 2013-12-03 2014-12-01 Use of pi3k-inhibitors WO2015082376A2 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
EP13195567.6 2013-12-03
EP13195567 2013-12-03
EP14163752 2014-04-07
EP14163752.0 2014-04-07

Publications (2)

Publication Number Publication Date
WO2015082376A2 WO2015082376A2 (en) 2015-06-11
WO2015082376A3 true WO2015082376A3 (en) 2015-07-30

Family

ID=51999440

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2014/076051 WO2015082376A2 (en) 2013-12-03 2014-12-01 Use of pi3k-inhibitors

Country Status (1)

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WO (1) WO2015082376A2 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20180104597A (en) 2015-11-07 2018-09-21 멀티비르 인코포레이티드 Compositions comprising tumor suppressor gene therapy and immune blockade for cancer therapy
US20200009203A1 (en) 2016-12-12 2020-01-09 Multivir Inc. Methods and compositions comprising viral gene therapy and an immune checkpoint inhibitor for treatment and prevention of cancer and infectious diseases
MX2020004666A (en) 2017-11-17 2022-01-26 Cellix Bio Private Ltd Compositions and methods for the treatment of eye disorders.
KR20200135986A (en) 2018-03-19 2020-12-04 멀티비르 인코포레이티드 Methods and compositions for cancer treatment comprising tumor suppressor gene therapy and CD122/CD132 agonists
WO2021113644A1 (en) 2019-12-05 2021-06-10 Multivir Inc. Combinations comprising a cd8+ t cell enhancer, an immune checkpoint inhibitor and radiotherapy for targeted and abscopal effects for the treatment of cancer

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2168583A1 (en) * 2008-09-24 2010-03-31 Bayer Schering Pharma Aktiengesellschaft Use of substituted 2,3-dihydroimidazo[1,2-c]quinazolines for the treatment of myeloma
WO2012062743A1 (en) * 2010-11-11 2012-05-18 Bayer Pharma Aktiengesellschaft Arylaminoalcohol-substituted 2,3-dihydroimidazo[1,2-c]quinolines
WO2012062748A1 (en) * 2010-11-11 2012-05-18 Bayer Pharma Aktiengesellschaft Aminoalcohol substituted 2,3-dihydroimidazo[1,2-c]quinazoline derivatives useful for treating hyper-proliferative disorders and diseases associated with angiogenesis
WO2012136549A1 (en) * 2011-04-05 2012-10-11 Bayer Pharma Aktiengesellschaft Use of substituted 2,3-dihydroimidazo[1,2-c]quinazolines
US20130184270A1 (en) * 2010-04-16 2013-07-18 Bayer Intellectual Property Gmbh Substituted 2,3-dihydroimidazo[1,2-c]quinazoline-containing combinations
WO2014166820A1 (en) * 2013-04-08 2014-10-16 Bayer Pharma Aktiengesllschaft Use of substituted 2,3-dihydroimidazo[1,2-c]quinazolines for treating lymphomas

Family Cites Families (2)

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US5023252A (en) 1985-12-04 1991-06-11 Conrex Pharmaceutical Corporation Transdermal and trans-membrane delivery of drugs
US5011472A (en) 1988-09-06 1991-04-30 Brown University Research Foundation Implantable delivery system for biological factors

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2168583A1 (en) * 2008-09-24 2010-03-31 Bayer Schering Pharma Aktiengesellschaft Use of substituted 2,3-dihydroimidazo[1,2-c]quinazolines for the treatment of myeloma
US20130184270A1 (en) * 2010-04-16 2013-07-18 Bayer Intellectual Property Gmbh Substituted 2,3-dihydroimidazo[1,2-c]quinazoline-containing combinations
WO2012062743A1 (en) * 2010-11-11 2012-05-18 Bayer Pharma Aktiengesellschaft Arylaminoalcohol-substituted 2,3-dihydroimidazo[1,2-c]quinolines
WO2012062748A1 (en) * 2010-11-11 2012-05-18 Bayer Pharma Aktiengesellschaft Aminoalcohol substituted 2,3-dihydroimidazo[1,2-c]quinazoline derivatives useful for treating hyper-proliferative disorders and diseases associated with angiogenesis
WO2012136549A1 (en) * 2011-04-05 2012-10-11 Bayer Pharma Aktiengesellschaft Use of substituted 2,3-dihydroimidazo[1,2-c]quinazolines
WO2014166820A1 (en) * 2013-04-08 2014-10-16 Bayer Pharma Aktiengesllschaft Use of substituted 2,3-dihydroimidazo[1,2-c]quinazolines for treating lymphomas

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
DIMITRIOS ZARDAVAS ET AL: "Emerging targeted agents in metastatic breast cancer", NATURE REVIEWS CLINICAL ONCOLOGY, NATURE, NY, US, vol. 10, 1 April 2013 (2013-04-01), pages 191 - 210, XP009174469, ISSN: 1759-4774 *
N. LIU ET AL: "BAY 80-6946 Is a Highly Selective Intravenous PI3K Inhibitor with Potent p110 and p110 Activities in Tumor Cell Lines and Xenograft Models", MOLECULAR CANCER THERAPEUTICS, vol. 12, no. 11, 29 October 2013 (2013-10-29), US, pages 2319 - 2330, XP055121310, ISSN: 1535-7163, DOI: 10.1158/1535-7163.MCT-12-0993-T *
SETH A. WANDER ET AL: "PI3K/mTOR inhibition can impair tumor invasion and metastasis in vivo despite a lack of antiproliferative action in vitro: implications for targeted therapy", BREAST CANCER RESEARCH AND TREATMENT, vol. 138, no. 2, 21 February 2013 (2013-02-21), pages 369 - 381, XP055164167, ISSN: 0167-6806, DOI: 10.1007/s10549-012-2389-6 *
YAN XIE ET AL: "Identification of upregulated phosphoinositide 3-kinase [gamma] as a target to suppress breast cancer cell migration and invasion", BIOCHEMICAL PHARMACOLOGY, vol. 85, no. 10, 1 May 2013 (2013-05-01), pages 1454 - 1462, XP055164166, ISSN: 0006-2952, DOI: 10.1016/j.bcp.2013.03.001 *

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