WO2013131499A1 - Polymeric composite with co-continual structure, especially for the preparation of implants with the increased bio-compatibility - Google Patents

Polymeric composite with co-continual structure, especially for the preparation of implants with the increased bio-compatibility Download PDF

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Publication number
WO2013131499A1
WO2013131499A1 PCT/CZ2013/000030 CZ2013000030W WO2013131499A1 WO 2013131499 A1 WO2013131499 A1 WO 2013131499A1 CZ 2013000030 W CZ2013000030 W CZ 2013000030W WO 2013131499 A1 WO2013131499 A1 WO 2013131499A1
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Prior art keywords
load
polymer
bearing frame
polymer composition
bioresorbable component
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PCT/CZ2013/000030
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French (fr)
Inventor
Vladimir SEDLARIK
Pavel KUCHARCZYK
Petr Saha
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Tomas Bata University In Zlin
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Publication of WO2013131499A1 publication Critical patent/WO2013131499A1/en

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/40—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
    • A61L27/44—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix
    • A61L27/48—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix with macromolecular fillers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
    • A61L29/12—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
    • A61L29/126—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/12—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
    • A61L31/125—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix
    • A61L31/129—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix containing macromolecular fillers
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G64/00—Macromolecular compounds obtained by reactions forming a carbonic ester link in the main chain of the macromolecule
    • C08G64/02—Aliphatic polycarbonates
    • C08G64/0208—Aliphatic polycarbonates saturated
    • C08G64/0225—Aliphatic polycarbonates saturated containing atoms other than carbon, hydrogen or oxygen
    • C08G64/0241—Aliphatic polycarbonates saturated containing atoms other than carbon, hydrogen or oxygen containing nitrogen
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J9/00—Working-up of macromolecular substances to porous or cellular articles or materials; After-treatment thereof
    • C08J9/26—Working-up of macromolecular substances to porous or cellular articles or materials; After-treatment thereof by elimination of a solid phase from a macromolecular composition or article, e.g. leaching out
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L23/00—Compositions of homopolymers or copolymers of unsaturated aliphatic hydrocarbons having only one carbon-to-carbon double bond; Compositions of derivatives of such polymers
    • C08L23/02—Compositions of homopolymers or copolymers of unsaturated aliphatic hydrocarbons having only one carbon-to-carbon double bond; Compositions of derivatives of such polymers not modified by chemical after-treatment
    • C08L23/04—Homopolymers or copolymers of ethene
    • C08L23/08—Copolymers of ethene
    • C08L23/0807—Copolymers of ethene with unsaturated hydrocarbons only containing more than three carbon atoms
    • C08L23/0815—Copolymers of ethene with aliphatic 1-olefins
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L67/00—Compositions of polyesters obtained by reactions forming a carboxylic ester link in the main chain; Compositions of derivatives of such polymers
    • C08L67/04—Polyesters derived from hydroxycarboxylic acids, e.g. lactones
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L77/00—Compositions of polyamides obtained by reactions forming a carboxylic amide link in the main chain; Compositions of derivatives of such polymers
    • C08L77/02—Polyamides derived from omega-amino carboxylic acids or from lactams thereof
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J2201/00—Foams characterised by the foaming process
    • C08J2201/04—Foams characterised by the foaming process characterised by the elimination of a liquid or solid component, e.g. precipitation, leaching out, evaporation
    • C08J2201/046—Elimination of a polymeric phase
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J2207/00—Foams characterised by their intended use
    • C08J2207/10—Medical applications, e.g. biocompatible scaffolds
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J2300/00—Characterised by the use of unspecified polymers
    • C08J2300/16—Biodegradable polymers
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J2400/00—Characterised by the use of unspecified polymers
    • C08J2400/16—Biodegradable polymers

Definitions

  • the invention is related to a polymer composition with co-continuous structure for preparation/modification of implants with enhanced biocompatibility.
  • the technical solution is designed for utilization in human and veterinary medicine.
  • Polymer implants for orthopedic and dental applications can be divided into two groups according to ' the way of their interaction with living organisms.
  • the ' first group - bioinert implants - includes polymers that do not biodegrade when present in organism, and thus they perform their function in original state, shape, size and within unchanged mechanical properties.
  • the second group - resorbable implants - consists of polymer materials, which can be resorbed (biodegraded) by living organisms arid they " are "gradually substituted 'by a tissue emerging during the healing process, which function was temporarily adopted by them.
  • bioinert polymer implants represent relatively easier solution in comparison with the resorbable ones.
  • polymer implants are not fully resistant against a long-term enzymatic effect and other relevant factors in a host organism. It can be a cause of their biocompatibility deterioration and subsequent health complications of a patient.
  • resorbable implants can be considered favourable due to their gradual and total resorption by the host organism. In certain applications it is very desirable. Negative aspect of the resorbable implants lies in difficulties in prediction of their degradation (resorption) kinetics and subsequent reduction of mechanical properties of the implants.
  • the above mentioned disadvantages and drawbacks of the known solutions of polymer implants intended primarily for orthopaedic and dental applications are - according to the invention- being considerably removed by the polymer composition with co-continuous structure, in particular for the preparation / revision of implants with enhanced biocompatibility.
  • the nature of the invention consists in that the polymer composition is formed by continuous structures of a load-bearing frame and a bioresorbable component, where the load-bearing frame is based on at least one bioinert polymer and the bioresorbable component is based on at least one polymer hydrolytically or enzymatically degradable in the environment of living organisms, and, simultaneously the mass ratio of the load-bearing frame and of the bioresorbable component is 20:80 to 80:20.
  • the load-bearing frame of the polymer composition is according to the invention preferably formed on the basis of polyolefins, polyurethanes, polyesters, vinyl polymers, polymethyl methacrylate and / or their copolymers.
  • the bioresorbable component is preferably composed of a material based on polylactide and/or its copolymers, polyanhydrides, starch and/or its derivatives and on water-soluble polymers - polyethylene glycol, polypropylene glycol, polyvinyl alcohol and / or poly vmylpyrrolidone.
  • the bioresorbable component of the polymer composition can according to the invention incorporate biologically active component, e.g. based on natural antibiotics, essence oils and/or aromatic extracts from natural materials.
  • the polymer composition can be used according to the invention not only as a self-supporting material forming the body of the implant, but can also be applied as a biocompatible coating on the regular implant formed by a bioinert polymer, metal and / or ceramic. ' *
  • Polymer composition according to the invention allows the increase in biocbmpatibility of implants manufactured thereof because it is characteristic of the two continuous arid interconnected phases - the load-bearing frame and the bioresorbable component.
  • gradual selective degradation and resorption of the continuous bioresorbable component occurs in the environment of the living organism.
  • the area that was originally occupied by the bioresorbable component is then formed by continuous cavities in the load-bearing frame, which may then be replaced with a tissue growing into the porous structure newly formed from the initially coherent implant.
  • the remaining porous and gradually filled up load-bearing frame then acts as a mechanical support for the newly created formation, grown-through with a tissue.
  • Polymer compositions according to the invention are well applicable especially in dental surgery, when the mechanical properties of the implant are being preserved, and, simultaneously, a great part of its substance is resorbed and substituted with a living tissue.
  • bioactive component is additionally incorporated into bioresorbable component. It is then released into the surrounding tissue environment during the process of degradation arid resorption of the bioresorbable component.
  • a supporting assimilation or healing effect caused by the gradual release of bioactive component can be expected. This speeds up the healing process at the implantation spot and also prevents any potential negative interaction caused by the influence of the operation, responses to the implant itself or any nosocomial infection.
  • FIG. 1 An illustration of polymer composition with co-continuous structures is represented by scanning electron micrograph in Figure 1. As described in Example 1, it shows the structure of polyamide 6 (PA6) based load-bearing frame after selective elimination of bioresorbable component based on polylactide (PLA).
  • Figure 2 represents parallel example where the load-bearing frarne is based on linear low density polyethylene (LDPE), as described in Example 2.
  • PA6 polyamide 6
  • LDPE linear low density polyethylene
  • Partially biodegradable polymer blends based on PA6 and PLA were mixed thermoplastically at 220 °C.
  • the blends were prepared with PLA concentration range from 50 to 60 wt. %.
  • Each of the PA6/PLA compositions was tested on occurrence of co-continuous structure. The fully developed co-continuous structure was found in case of the composition PA6/PLA 40/60 (see Figure 1).
  • Partially biodegradable polymer blends based on LDPE and PLA were mixed thermoplastically at 160 °C.
  • the blends were prepared with PLA concentration range from 40 to 60 wt. %.
  • Each of the LDPE/PLA compositions was tested on occurrence of co-continuous structure. The fully developed co-continuous structure was found in case of the composition LDPE/PLA 50/50 (see Figure 2).
  • Polymer blends were prepared according Example 1 with exception of that 1 wt. % (related to total amount of polymers) of crystal violet (tris(4-(dimethylamino)phenyl)methylium chloride, CAS 548-62-9) (CV) was added to the blends. Resulting blends were put to hydrolytical degradation experiment under various pHs (3, 7 and 9). The concentration of the released CV was monitored subsequently. The results indicated that the maximal release of CV was detected in case of the compositions with co-continuous structures as mentioned in Example 1.
  • crystal violet tris(4-(dimethylamino)phenyl)methylium chloride, CAS 548-62-9)
  • Polymer blends were prepared according Example 1 with exception of that 1 wt. % (related to total amount of polymers) of crystal violet (tris(4-(dimethylamino)phenyl)methylium chloride, CAS 548-62-9) (CV) was added to the blends. Resulting blends were put to hydrolytical degradation experiment under various pHs (3, 7 and 9). The concentration of the released CV was monitored subsequently. The results indicated that the maximal release of CV was detected in case of the compositions with co-continuous structures as mentioned in Example 2.
  • crystal violet tris(4-(dimethylamino)phenyl)methylium chloride, CAS 548-62-9)
  • Polymer composition with co-continuous structure according to the invention is applicable especially in human and veterinary medicine. It represents a material with characteristics that predetermines it for preparation of implants with enhanced biocompatibility. The presence of biodegradable/bioresorbable component can be availed for controlled release of bioactive substances.
  • the nature of the invention consists in that the polymer composition is formed by continuous structures of a load-bearing frame and a bioresorbable component, where the load- bearing frame is based on at least one bioinert polymer and the bioresorbable component is based on at least one polymer hydrolytically degradable in the environment of living organisms, and, simultaneously the mass ratio of the load-bearing frame and of the bioresorbable component is 20:80 to 80:20.

Abstract

Polymer composition with co-continuous structure is formed by continuous structures of a load-bearing frame and a bioresorbable component, where the load-bearing frame is based on at least one bioinert polymer and the bioresorbable component is based on at least one polymer hydrolytically or enzymatically degradable in the environment of living organisms, and, simultaneously the mass ratio of the load-bearing frame and of the bioresorbable component is 20:80 to 80:20. The load-bearing frame of the polymer composition is preferably formed on the basis of polyolefins, polyurethanes, polyesters, vinyl polymers, polymethyl methacrylate and / or their copolymers. The bioresorbable component is preferably created of a material based on polylactide and/or its copolymers, polyanhydrides, starch and/or its derivatives and on water-soluble polymers - polyethylene glycol, polypropylene glycol, polyvinyl alcohol and / or polyvinylpyrrolidone.

Description

Polymeric Composite with Co-continual Structure, especially for the Preparation of Implants with the Increased Bio-compatibility
Field of Invention
The invention is related to a polymer composition with co-continuous structure for preparation/modification of implants with enhanced biocompatibility. The technical solution is designed for utilization in human and veterinary medicine.
State of Art
Polymer implants for orthopedic and dental applications can be divided into two groups according to' the way of their interaction with living organisms. The' first group - bioinert implants - includes polymers that do not biodegrade when present in organism, and thus they perform their function in original state, shape, size and within unchanged mechanical properties. The second group - resorbable implants - consists of polymer materials, which can be resorbed (biodegraded) by living organisms arid they" are "gradually substituted 'by a tissue emerging during the healing process, which function was temporarily adopted by them.
The bioinert polymer implants represent relatively easier solution in comparison with the resorbable ones. However, polymer implants are not fully resistant against a long-term enzymatic effect and other relevant factors in a host organism. It can be a cause of their biocompatibility deterioration and subsequent health complications of a patient.
On the other hand resorbable implants can be considered favourable due to their gradual and total resorption by the host organism. In certain applications it is very desirable. Negative aspect of the resorbable implants lies in difficulties in prediction of their degradation (resorption) kinetics and subsequent reduction of mechanical properties of the implants.
Considering the above mentioned facts, there are efforts for fulfilling the demands for trouble- free incorporation of the implants into organism. Because of that, polymeric materials that are biocompatible and sufficiently stable (i.e. bioinert) and/or slowly resorbable are being selected for implant production. Incorporation of the implant into organism is supported by
SUBSTITUTE SHEET creation of a porous structure that is gradually grown through by the bodily tissue. This solution seems to be advantageous; however, reduction in mechanical strength and other important physico-chemical properties can be caused due to the porous structure formation.
Nature of Invention
The above mentioned disadvantages and drawbacks of the known solutions of polymer implants intended primarily for orthopaedic and dental applications are - according to the invention- being considerably removed by the polymer composition with co-continuous structure, in particular for the preparation / revision of implants with enhanced biocompatibility. The nature of the invention consists in that the polymer composition is formed by continuous structures of a load-bearing frame and a bioresorbable component, where the load-bearing frame is based on at least one bioinert polymer and the bioresorbable component is based on at least one polymer hydrolytically or enzymatically degradable in the environment of living organisms, and, simultaneously the mass ratio of the load-bearing frame and of the bioresorbable component is 20:80 to 80:20.
The load-bearing frame of the polymer composition is according to the invention preferably formed on the basis of polyolefins, polyurethanes, polyesters, vinyl polymers, polymethyl methacrylate and / or their copolymers. The bioresorbable component is preferably composed of a material based on polylactide and/or its copolymers, polyanhydrides, starch and/or its derivatives and on water-soluble polymers - polyethylene glycol, polypropylene glycol, polyvinyl alcohol and / or poly vmylpyrrolidone.
The bioresorbable component of the polymer composition can according to the invention incorporate biologically active component, e.g. based on natural antibiotics, essence oils and/or aromatic extracts from natural materials.
The polymer composition can be used according to the invention not only as a self-supporting material forming the body of the implant, but can also be applied as a biocompatible coating on the regular implant formed by a bioinert polymer, metal and / or ceramic. ' *
Polymer composition according to the invention allows the increase in biocbmpatibility of implants manufactured thereof because it is characteristic of the two continuous arid interconnected phases - the load-bearing frame and the bioresorbable component. In the case of an implant made of such a composition, gradual selective degradation and resorption of the continuous bioresorbable component occurs in the environment of the living organism.
The area that was originally occupied by the bioresorbable component is then formed by continuous cavities in the load-bearing frame, which may then be replaced with a tissue growing into the porous structure newly formed from the initially coherent implant. The remaining porous and gradually filled up load-bearing frame then acts as a mechanical support for the newly created formation, grown-through with a tissue.
Polymer compositions according to the invention are well applicable especially in dental surgery, when the mechanical properties of the implant are being preserved, and, simultaneously, a great part of its substance is resorbed and substituted with a living tissue.
Other advantages of polymer composition according to the invention gain importance in cases ' where the bioactive component is additionally incorporated into bioresorbable component. It is then released into the surrounding tissue environment during the process of degradation arid resorption of the bioresorbable component. In addition to the increasing compatibility caused by penetration of tissue into the implant, also a supporting assimilation or healing effect caused by the gradual release of bioactive component can be expected. This speeds up the healing process at the implantation spot and also prevents any potential negative interaction caused by the influence of the operation, responses to the implant itself or any nosocomial infection.
Overview of Images in Drawings
The attached drawings provide further information on nature of the invention. An illustration of polymer composition with co-continuous structures is represented by scanning electron micrograph in Figure 1. As described in Example 1, it shows the structure of polyamide 6 (PA6) based load-bearing frame after selective elimination of bioresorbable component based on polylactide (PLA). Figure 2 represents parallel example where the load-bearing frarne is based on linear low density polyethylene (LDPE), as described in Example 2.
Examples of technical implementation
Example 1
Partially biodegradable polymer blends based on PA6 and PLA were mixed thermoplastically at 220 °C. The blends were prepared with PLA concentration range from 50 to 60 wt. %. Each of the PA6/PLA compositions was tested on occurrence of co-continuous structure. The fully developed co-continuous structure was found in case of the composition PA6/PLA 40/60 (see Figure 1).
Example 2
Partially biodegradable polymer blends based on LDPE and PLA were mixed thermoplastically at 160 °C. The blends were prepared with PLA concentration range from 40 to 60 wt. %. Each of the LDPE/PLA compositions was tested on occurrence of co-continuous structure. The fully developed co-continuous structure was found in case of the composition LDPE/PLA 50/50 (see Figure 2).
Example 3
Polymer blends were prepared according Example 1 with exception of that 1 wt. % (related to total amount of polymers) of crystal violet (tris(4-(dimethylamino)phenyl)methylium chloride, CAS 548-62-9) (CV) was added to the blends. Resulting blends were put to hydrolytical degradation experiment under various pHs (3, 7 and 9). The concentration of the released CV was monitored subsequently. The results indicated that the maximal release of CV was detected in case of the compositions with co-continuous structures as mentioned in Example 1.
Example 4
Polymer blends were prepared according Example 1 with exception of that 1 wt. % (related to total amount of polymers) of crystal violet (tris(4-(dimethylamino)phenyl)methylium chloride, CAS 548-62-9) (CV) was added to the blends. Resulting blends were put to hydrolytical degradation experiment under various pHs (3, 7 and 9). The concentration of the released CV was monitored subsequently. The results indicated that the maximal release of CV was detected in case of the compositions with co-continuous structures as mentioned in Example 2.
Industrial applicability
Polymer composition with co-continuous structure according to the invention is applicable especially in human and veterinary medicine. It represents a material with characteristics that predetermines it for preparation of implants with enhanced biocompatibility. The presence of biodegradable/bioresorbable component can be availed for controlled release of bioactive substances.
The nature of the invention consists in that the polymer composition is formed by continuous structures of a load-bearing frame and a bioresorbable component, where the load- bearing frame is based on at least one bioinert polymer and the bioresorbable component is based on at least one polymer hydrolytically degradable in the environment of living organisms, and, simultaneously the mass ratio of the load-bearing frame and of the bioresorbable component is 20:80 to 80:20.

Claims

PATENT CLAIMS
1. Polymer composition with co-continuous structure especially for preparation/modification of implants with enhanced biocompatibility is characterized in that it consists continuous structures of a load-bearing frame and a bioresorbable component, where the load-bearing frame is based on at least one bioinert polymer and bioresorbable component is based on at least one polymer hydrolytically or enzymatically degradable in the environment of living organisms, and, simultaneously the mass ratio of the load-bearing frame and of the bioresorbable component is 20:80 to 80:20.
2. Polymer composition according to the claim 1 is characterized in that the load-bearing frame is based on polyolefins, polyurethanes, polyesters, vinyl polymers, polymethyl methacrylate and/or their copolymers.
3. Polymer composition according to the claim 1 is characterized in that the bioresorbable component is based on polylactide and/or its copolymers, polyanhydrides, starch and/or its derivatives and water-soluble polymers - polyethylene glycol, polypropylene glycol, polyvinyl alcohol and/or polyvinylpyrrolidone .
4. Polymer composition according to the claim 1 is characterized in that the bioresorbable component contains a bioactive substance, based especially on natural antibiotics, essential oils and/or aromatic natural extracts.
5. Polymer composition according to the claim 1 is characterized in that polymer composition creates a biocompatible surface layer on the commonly used implants based on bioinert polymer, metal and/or ceramics.
PCT/CZ2013/000030 2012-03-08 2013-03-08 Polymeric composite with co-continual structure, especially for the preparation of implants with the increased bio-compatibility WO2013131499A1 (en)

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CZ20120164A CZ2012164A3 (en) 2012-03-08 2012-03-08 Polymeric composition with co-continuous structure intended especially for preparation of implants of increased biocompatibility

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Cited By (1)

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Publication number Priority date Publication date Assignee Title
WO2018233793A1 (en) * 2017-06-21 2018-12-27 Jonsman Innovation Aps Hydrophilic, moldable polymer blends and uses thereof

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EP0460439A2 (en) * 1990-06-07 1991-12-11 American Cyanamid Company Deformable surgical device
WO2003103925A1 (en) * 2002-06-06 2003-12-18 Rutgers, The State University Co-continuous phase composite polymer blends for in-vivo and in-vitro biomedical applications
WO2010070274A2 (en) * 2008-12-16 2010-06-24 The University Of Nottingham Degradable composite

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DE4216496C2 (en) * 1992-05-19 1994-09-22 Werner Prof Dr Med Sattel Use of a lead body for insertion into a bone cavity, in particular in the medullary cavity of a long bone
US6514535B2 (en) * 1999-05-21 2003-02-04 Noveon Ip Holdings Corp. Bioadhesive hydrogels with functionalized degradable crosslinks
GB0202233D0 (en) * 2002-01-31 2002-03-20 Smith & Nephew Bioresorbable polymers
US7951436B2 (en) * 2006-08-14 2011-05-31 Frito-Lay North America, Inc. Environmentally-friendly multi-layer flexible film having barrier properties

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Publication number Priority date Publication date Assignee Title
US3797499A (en) * 1970-05-13 1974-03-19 Ethicon Inc Polylactide fabric graphs for surgical implantation
EP0460439A2 (en) * 1990-06-07 1991-12-11 American Cyanamid Company Deformable surgical device
WO2003103925A1 (en) * 2002-06-06 2003-12-18 Rutgers, The State University Co-continuous phase composite polymer blends for in-vivo and in-vitro biomedical applications
WO2010070274A2 (en) * 2008-12-16 2010-06-24 The University Of Nottingham Degradable composite

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2018233793A1 (en) * 2017-06-21 2018-12-27 Jonsman Innovation Aps Hydrophilic, moldable polymer blends and uses thereof

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