WO2013066731A3 - Protective vaccine based on staphylococcus aureus sa2451 protein - Google Patents

Protective vaccine based on staphylococcus aureus sa2451 protein Download PDF

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Publication number
WO2013066731A3
WO2013066731A3 PCT/US2012/062019 US2012062019W WO2013066731A3 WO 2013066731 A3 WO2013066731 A3 WO 2013066731A3 US 2012062019 W US2012062019 W US 2012062019W WO 2013066731 A3 WO2013066731 A3 WO 2013066731A3
Authority
WO
WIPO (PCT)
Prior art keywords
staphylococcus aureus
protein
vaccine based
methods
protective vaccine
Prior art date
Application number
PCT/US2012/062019
Other languages
French (fr)
Other versions
WO2013066731A2 (en
Inventor
Tessie Mcneely
Donna Lorraine MONTGOMERY
Leslie Cope
Amita Joshi
Gregory D. PANCARI
Hongxia Fan
Original Assignee
Merck Sharp & Dohme Corp.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Sharp & Dohme Corp. filed Critical Merck Sharp & Dohme Corp.
Priority to EP12844888.3A priority Critical patent/EP2773370A4/en
Priority to US14/354,948 priority patent/US9527892B2/en
Publication of WO2013066731A2 publication Critical patent/WO2013066731A2/en
Publication of WO2013066731A3 publication Critical patent/WO2013066731A3/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/305Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Micrococcaceae (F)
    • C07K14/31Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Micrococcaceae (F) from Staphylococcus (G)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/02Bacterial antigens
    • A61K39/085Staphylococcus
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/39Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants

Abstract

Methods of inducing an immune response to Staphylococcus comprising administering a composition comprising an SA2451 -related polypeptide from Staphylococcus aureus as well as derivatives or fragments thereof are disclosed. Methods of treating and/or reducin the likelihood of a Staphylococcus infection by administering a composition comprising an SA2451 -related polypeptide or an antibody that specifically binds to an SA2451 polypeptide, derivative or fragments thereof are also disclosed. Compositions administered in the methods can include one or more additional antigens.
PCT/US2012/062019 2011-10-31 2012-10-26 Protective vaccine based on staphylococcus aureus sa2451 protein WO2013066731A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
EP12844888.3A EP2773370A4 (en) 2011-10-31 2012-10-26 Protective vaccine based on staphylococcus aureus sa2451 protein
US14/354,948 US9527892B2 (en) 2011-10-31 2012-10-26 Protective vaccine based on Staphylococcus aureus SA2451 protein

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161553589P 2011-10-31 2011-10-31
US61/553,589 2011-10-31

Publications (2)

Publication Number Publication Date
WO2013066731A2 WO2013066731A2 (en) 2013-05-10
WO2013066731A3 true WO2013066731A3 (en) 2015-06-11

Family

ID=48192999

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2012/062019 WO2013066731A2 (en) 2011-10-31 2012-10-26 Protective vaccine based on staphylococcus aureus sa2451 protein

Country Status (3)

Country Link
US (1) US9527892B2 (en)
EP (1) EP2773370A4 (en)
WO (1) WO2013066731A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9376487B2 (en) 2012-07-10 2016-06-28 Merck Sharp & Dohme Corp. Protective vaccine based on Staphylococcus aureus SA2493 protein

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7608276B2 (en) * 2001-03-27 2009-10-27 Novartis Vaccines And Diagnostics Srl Staphylococcus aureus proteins and nucleic acids

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GB9706078D0 (en) * 1997-03-24 1997-05-14 Chiron Spa Screening method and proteins and dna identified thereby
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AU7337000A (en) 1999-09-01 2001-03-26 Human Genome Sciences, Inc. 37 staphylococcus aureus genes and polypeptides
GB0014907D0 (en) 2000-06-20 2000-08-09 Univ Sheffield Antigenic polypeptides
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WO2005009378A2 (en) 2003-07-24 2005-02-03 Merck & Co., Inc. Polypeptides for inducing a protective immune response against staphylococcus aureus
DK1651166T3 (en) 2003-07-24 2010-05-31 Merck Sharp & Dohme Polypeptide to induce a protective immune response against staphylococcus aureus
EP1725575B1 (en) 2004-02-18 2012-11-28 Merck Sharp & Dohme Corp. Polypeptides for inducing a protective immune response against staphylococcus aureus
EP1725255A4 (en) 2004-02-27 2007-07-11 Merck & Co Inc Polypeptides for inducing a protective immune response against staphylococcus aureus
AU2005247435A1 (en) 2004-05-25 2005-12-08 Merck & Co., Inc. Polypeptides for inducing a protective immune response against Staphylococcus aureus
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WO2006033918A2 (en) 2004-09-17 2006-03-30 Merck & Co., Inc. Polypeptides for inducing a protective immune response against staphylococcus aureus
EP2305295B1 (en) 2004-09-22 2015-04-01 GlaxoSmithKline Biologicals SA Antibody composition for use in vaccination against staphylococcei
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EP2374467B1 (en) 2007-05-04 2013-08-28 Martin Krönke Protective staphylococcus aureus vaccine based on cell wall-associated proteins
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Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7608276B2 (en) * 2001-03-27 2009-10-27 Novartis Vaccines And Diagnostics Srl Staphylococcus aureus proteins and nucleic acids

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
DATABASE UNIPROT [online] 21 September 2011 (2011-09-21), "Glycine betaine/camitine/choline ABC transporter opuCC.", XP055293072, retrieved from IBIS Database accession no. C8KK51 *
SIVARAMAN ET AL.: "Genome Sequencing and analysis reveals possible determinants of Staphylococcus aureus nasal carriage.", BMC GENOMICS, vol. 9, no. 433, 22 September 2008 (2008-09-22), pages 1 - 13, XP021042171, Retrieved from the Internet <URL:http://www.biomedcentral.com/content/pdf/1471-2164-9-433.pdf> [retrieved on 20121213] *
SIVARAMAN ET AL.: "Pathogenesis gene families in the common minimal genome of Staphylococcus aureus are hypervariable.", FEBS LETT., vol. 583, no. 8, 17 April 2009 (2009-04-17), pages 1304 - 1308, XP026096524 *
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Also Published As

Publication number Publication date
WO2013066731A2 (en) 2013-05-10
EP2773370A2 (en) 2014-09-10
EP2773370A4 (en) 2016-09-28
US9527892B2 (en) 2016-12-27
US20140294888A1 (en) 2014-10-02

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