WO2011109039A1 - System for forming and modifying lenses and lenses formed thereby - Google Patents

System for forming and modifying lenses and lenses formed thereby Download PDF

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Publication number
WO2011109039A1
WO2011109039A1 PCT/US2010/048161 US2010048161W WO2011109039A1 WO 2011109039 A1 WO2011109039 A1 WO 2011109039A1 US 2010048161 W US2010048161 W US 2010048161W WO 2011109039 A1 WO2011109039 A1 WO 2011109039A1
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WO
WIPO (PCT)
Prior art keywords
lens
absorber
layer
weight
laser
Prior art date
Application number
PCT/US2010/048161
Other languages
French (fr)
Inventor
Josef F. Bille
Stephen Q. Zhou
Original Assignee
Aaren Scientific Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US12/717,866 external-priority patent/US8646916B2/en
Priority claimed from PCT/US2010/026281 external-priority patent/WO2010102156A1/en
Priority claimed from US12/717,886 external-priority patent/US8292952B2/en
Application filed by Aaren Scientific Inc. filed Critical Aaren Scientific Inc.
Priority to US13/582,017 priority Critical patent/US20130103144A1/en
Priority to EP10847149.1A priority patent/EP2542183A4/en
Priority to CN201080066621XA priority patent/CN102883681A/en
Publication of WO2011109039A1 publication Critical patent/WO2011109039A1/en

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Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02Prostheses implantable into the body
    • A61F2/14Eye parts, e.g. lenses, corneal implants; Implanting instruments specially adapted therefor; Artificial eyes
    • A61F2/16Intraocular lenses
    • A61F2/1613Intraocular lenses having special lens configurations, e.g. multipart lenses; having particular optical properties, e.g. pseudo-accommodative lenses, lenses having aberration corrections, diffractive lenses, lenses for variably absorbing electromagnetic radiation, lenses having variable focus
    • A61F2/1624Intraocular lenses having special lens configurations, e.g. multipart lenses; having particular optical properties, e.g. pseudo-accommodative lenses, lenses having aberration corrections, diffractive lenses, lenses for variably absorbing electromagnetic radiation, lenses having variable focus having adjustable focus; power activated variable focus means, e.g. mechanically or electrically by the ciliary muscle or from the outside
    • A61F2/1627Intraocular lenses having special lens configurations, e.g. multipart lenses; having particular optical properties, e.g. pseudo-accommodative lenses, lenses having aberration corrections, diffractive lenses, lenses for variably absorbing electromagnetic radiation, lenses having variable focus having adjustable focus; power activated variable focus means, e.g. mechanically or electrically by the ciliary muscle or from the outside for changing index of refraction, e.g. by external means or by tilting
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02Prostheses implantable into the body
    • A61F2/14Eye parts, e.g. lenses, corneal implants; Implanting instruments specially adapted therefor; Artificial eyes
    • A61F2/16Intraocular lenses
    • A61F2/1613Intraocular lenses having special lens configurations, e.g. multipart lenses; having particular optical properties, e.g. pseudo-accommodative lenses, lenses having aberration corrections, diffractive lenses, lenses for variably absorbing electromagnetic radiation, lenses having variable focus
    • A61F2/1654Diffractive lenses
    • A61F2/1656Fresnel lenses, prisms or plates
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F9/00Methods or devices for treatment of the eyes; Devices for putting-in contact lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
    • A61F9/007Methods or devices for eye surgery
    • A61F9/008Methods or devices for eye surgery using laser
    • A61F9/00825Methods or devices for eye surgery using laser for photodisruption
    • A61F9/00827Refractive correction, e.g. lenticle
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F9/00Methods or devices for treatment of the eyes; Devices for putting-in contact lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
    • A61F9/007Methods or devices for eye surgery
    • A61F9/008Methods or devices for eye surgery using laser
    • A61F9/00825Methods or devices for eye surgery using laser for photodisruption
    • A61F9/00834Inlays; Onlays; Intraocular lenses [IOL]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02Prostheses implantable into the body
    • A61F2/14Eye parts, e.g. lenses, corneal implants; Implanting instruments specially adapted therefor; Artificial eyes
    • A61F2/16Intraocular lenses
    • A61F2002/16965Lens includes ultraviolet absorber
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F9/00Methods or devices for treatment of the eyes; Devices for putting-in contact lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
    • A61F9/007Methods or devices for eye surgery
    • A61F9/008Methods or devices for eye surgery using laser
    • A61F2009/00842Permanent Structural Change [PSC] in index of refraction; Limit between ablation and plasma ignition
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F9/00Methods or devices for treatment of the eyes; Devices for putting-in contact lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
    • A61F9/007Methods or devices for eye surgery
    • A61F9/008Methods or devices for eye surgery using laser
    • A61F2009/00844Feedback systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F9/00Methods or devices for treatment of the eyes; Devices for putting-in contact lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
    • A61F9/007Methods or devices for eye surgery
    • A61F9/008Methods or devices for eye surgery using laser
    • A61F2009/00861Methods or devices for eye surgery using laser adapted for treatment at a particular location
    • A61F2009/0087Lens
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F9/00Methods or devices for treatment of the eyes; Devices for putting-in contact lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
    • A61F9/007Methods or devices for eye surgery
    • A61F9/008Methods or devices for eye surgery using laser
    • A61F9/00825Methods or devices for eye surgery using laser for photodisruption
    • A61F9/00838Correction of presbyopia
    • GPHYSICS
    • G02OPTICS
    • G02CSPECTACLES; SUNGLASSES OR GOGGLES INSOFAR AS THEY HAVE THE SAME FEATURES AS SPECTACLES; CONTACT LENSES
    • G02C2202/00Generic optical aspects applicable to one or more of the subgroups of G02C7/00
    • G02C2202/14Photorefractive lens material

Definitions

  • Lenses are implanted in eyes to improve vision.
  • intraocular lenses There are two types of intraocular lenses.
  • One type replaces the eye's natural lens, usually to replace a cataractous lens.
  • the other type is used to supplement an existing lens and functions as a permanent corrective lens.
  • Replacement type of lenses are implanted in the posterior chamber.
  • a supplemental type of lens referred to as a phakic IOL (intraocular lens), is implanted in the anterior or posterior chamber to correct refractive errors of the eye.
  • One technique is molding, where an optical polymeric material is formed into a desired shape having a predetermined dioptic power. These lenses are available in standard diopter powers, typically differing in about 0.5 diopter power. A problem with the molding technique is it is a very expensive way to make a customized lens, and thus for most patients, only an approximate approach to clear vision is obtained. For some patients the diopter power can be wrong by 0.25 or more. Moreover, such lenses generally are not as effective for patients who have an abnormally shaped cornea, including some that have undergone a cornea procedure, such as LAS IK surgery.
  • the other technique used is lathing and milling, where a disc shaped lens blank is ground to a desired shape. Due to the properties of the materials used for intraocular lenses, it is preferable to machine lenses at a reduced temperature such as -10° F.
  • a problem with lathing and milling is that the optical properties of a lens at -10° F may be different than the optical properties of the lens at body temperature, and thus such a lens only approximates optimal vision.
  • the lens warms it absorbs moisture and dimensions of the lens may change, thus altering the diopter power of the lens.
  • the lenses be aspheric to correct corneal spherical aberrations or toric to correct or mitigate corneal astigmatism over a range of diopters.
  • Commercially available IO Ls generally cannot uniformly correct these optical defects because it would be necessary to inventory hundreds, if not thousands, of different types of lenses, all varying in dioptic power, and aspheric and toric features.
  • LASIK laser assisted in situ keratomileusis
  • a technique for modifying the refractive index of an optical polymeric material such as in an IOL is discussed in Knox et al., U.S. Publication No. 2008/0001320. This technique uses a laser for changing the refractive index of small areas of an optical material, resulting in changes in refractive index of up to about 0.06, which is an inadequate change in diopter power for most applications.
  • a lens formed by this system has unique properties.
  • the lenses typically are IOLs, but the invention has other applications, as discussed below.
  • a lens according to this invention comprises a body formed of an optical material having a refractive index.
  • the body has opposed anterior and posterior surfaces, and an optical axis.
  • the body contains modified loci.
  • the modified loci have been formed by a laser beam and have a different refractive index than the material before modification.
  • the optical properties of a polymeric lens sized for placement in a human eye is modified by modifying loci of the lens with a laser beam so the modified loci have a different refractive index than the material before modification.
  • the laser beam travels at rate of at least 50 mm per second, but typically at a rate of no more than about 200 mm per second.
  • the lens can contain at least 5% by weight UV absorber and with at least 150 ppm by weight of yellow dye.
  • the amount of yellow dye is preferably at least about 500 ppm by weight, and can be up to about 1000 ppm by weight. It is desirable that the lens has a glass transition temperature equal to or less than 37 °C, and more preferably less than about 20 °C, so it can be folded for insertion into the human eye.
  • the laser system can also be used for modifying at least one optical property of the cornea in situ in the human eye by modifying loci in the cornea with a laser beam, the modified loci have a different refractive index than before modification.
  • the modified loci are in a planar layer substantially parallel to the anterior surface of the cornea.
  • the layer has an upper surface about 100 microns below the anterior surface of the cornea.
  • the layer typically is about 50 microns thick.
  • Fig. 1A is a front elevation view of an intraocular lens having features of the present invention
  • Fig. IB is a top plan view of the lens of Fig. 1 A;
  • Fig. 2 schematically shows a portion of the body of an intraocular lens having two layers of modified loci
  • Fig. 3 schematically shows a lens body having multiple layers of modified loci, where some of the layers are formed after placement of the lens in an eye;
  • Fig. 4A is a schematic view of one layer of the lens of Fig. 1 modified to generate a spherical focusing effect
  • Fig. 4B is a top plan view of the layer shown in Fig. 4A;
  • Fig. 4C is a schematic view of a layer of the lens of Fig. 1 modified to generate an aspherical focusing effect
  • Fig. 4D is a schematic view of a layer of the lens of Fig. 1 providing a defocusing meridian to accommodate for astigmatism;
  • Fig. 4E is a schematic top plan view of the layer of the lens of Fig. 4D at the horizontal meridian;
  • Figs. 5 and 6 schematically show the principles utilized for forming the modified loci
  • Fig. 7 schematically shows the layout of an apparatus according to the present invention for forming the aforementioned lenses
  • Fig. 8 shows a flow chart for an algorithm useful in the apparatus of Fig. 7;
  • Fig. 9 graphically shows the effect of including a UV absorber in material used for forming a lens
  • Fig. 10A graphically shows the relationship between the change of the index of refraction of modified loci as a function of laser pulse energy
  • Fig. 10B graphically shows the relationship between the change in refractive index of a modified lens as a function of the number of laser beam pulses at a fixed pulse energy
  • Fig. 11 schematically represents forming a lens according to the present invention using a layered raster- scan method
  • Fig. 12 schematically represents forming a lens according to the present invention using a layered flying spot scanning method
  • Fig. 13 schematically shows a process for creating a refractive layer structure by point wise variation of a change in refractive index
  • Fig. 14 schematically shows how a natural lens can be modified in situ
  • Fig. 15 schematically shows a modified layer in the human cornea
  • Figs. 16 and 17 graphically show the results of experiments.
  • Customized intraocular lens referred to as a Customized Intraocular Phase Shifting Membrane (C-IPSM)
  • C-IPSM Customized Intraocular Phase Shifting Membrane
  • a laser unit optionally can generate laser beam pulses at 50 MHz, with each pulse having duration of about 100 femtoseconds and an energy level of about 0.2 to about one nanojoule.
  • the focal spot of the laser beam is moved over a surface of plastic material having a refractive index "n 0 ". This alters a sub-surface layer by creating a pattern of changes in the refractive index of the material ( ⁇ ).
  • the customized intraocular lens is fabricated from a flat sheet of plastic that has a first side and a second side, and a thickness of from about 50 to about 400 mm between the two sides.
  • the laser unit alters a sub-surface layer having a depth of only about 50 microns.
  • the purpose of the layer of altered material in the layer is to compensate for optical aberrations of the patient to receive the C-IPSM. Specifically, this compensates for optical aberrations introduced into a light beam by an optical system (e.g. an eye).
  • the pattern of refractive index changes created in the plastic sheet results from exposing the plastic material to the electronic disruption and heat created by the layer in a predetermined manner.
  • this change in refractive index is accomplished by sequentially focusing a laser beam onto a plethora of contiguous loci in the material.
  • the result at each locus is an Optical Path Difference (OPD) for light passing through the spot.
  • OPD Optical Path Difference
  • Each locus can be created with the laser unit using a predetermined number of laser bursts (i.e. an "i" number of bursts).
  • each burst includes approximately 50 pulses and is approximately 1 microsecond in duration.
  • an alteration of a substantially cylindrical volume of material occurs through a depth of approximately five microns with a diameter of about one micron.
  • a locus contains at least one site, and typically up to 10 sites.
  • i there is approximately a ⁇ /10 change for every 5 microns of locus depth (i.e. "i" is in a range of 1 to 10).
  • the laser unit is refocused onto the locus two more times, with the focal point of the laser beam being withdrawn each time through a distance of five microns for each subsequent burst.
  • a locus can be created by advancing, rather than withdrawing, the focal point of the laser beam.
  • each locus is created with the laser unit using a varying number of pulses per laser burst.
  • Each laser burst creates a site, there being from 1 to 10 sites per locus.
  • each burst includes between 5 pulses and 50 pulses and is approximately 100 nanoseconds to 1 microsecond in duration.
  • an alteration of a substantially cylindrical volume of material occurs through a depth of approximately five microns with a diameter of about one micron.
  • each burst causes an OPD of about one-hundreds of a wavelength ( ⁇ /100) to one-tenth of a wavelength ( ⁇ /10).
  • a predetermined OPD in this example one- tenth of a wavelength ( ⁇ /10), resulting from (10 x ( ⁇ /100))
  • ⁇ /10 a wavelength
  • Variations in OPD are incurred via the change in ⁇ from locus to locus, as the femtosecond laser beam is moved in a transverse direction, i.e. parallel to the surface of the plastic membrane.
  • C- IPSM customized intraocular lens
  • the refraction of an incoming beam by the customized intraocular lens makes the optical path lengths of individual beams in any incoming beam appear to be substantially equal to each other.
  • an incoming beam which carries the image information is compensated by the customized intraocular lens (C-IPSM) to account for the refractive aberrations of the pseudophakic eye that are evidenced by the appropriate measurement data.
  • C-IPSM the customized intraocular lens
  • several refractive and diffractive optical principles can be employed for different modifications of the performance of the customized intraocular lens (C-IPSM).
  • the designs comprise refractive, with or without phase wrapping, and diffractive phase ("GRIN") structures. Spherical, aspherical, achromatic, bifocal and multifocal embodiments are possible.
  • Lenses having features of the present invention can be of any type of lens implanted in the eye, including contact lenses, intraocular lenses placed in the anterior or posterior chamber, and corneal lenses.
  • IOLs placed in the posterior chamber often can be phakic when the natural crystalline lens is present and pseudophakic where the natural crystalline lens has been removed such as by cataract surgery.
  • the invention is also useful for modifying lenses in situ, including lenses such as contact lenses in the anterior chamber, IOLs in the posterior chamber or anterior chamber, the natural cornea and natural crystalline lenses.
  • both the anterior surface 14 and posterior surface 16 are substantially planar, i.e., they have little or no curvature such as concave or convex curvature.
  • Use of the techniques of the present invention allows a plano-plano intraocular lens to be formed.
  • anterior and posterior refer to surfaces of a lens as it is normally placed in the human eye, with the anterior surface 14 facing outwardly, and the posterior surface 16 facing inwardly toward the retina.
  • the lens 10 has an optical axis 19, which is an imaginary line that defines the path along which light propagates through the lens 10.
  • the optical axis 19 is coincident with the lens's mechanical axis, but this is not required.
  • optical effects of the lens be provided by modified locus in the body 12, as described below, it is possible that corrective optical effects can also be provided in the conventional way, such as by having the anterior surface, the posterior surface, or both curved, such as convex, concave, or complex curvature. It is not necessary that all optical corrections be provided by modified loci according to the present invention, although that is the preferred.
  • a lens having features of the present invention can be used for correcting vision errors, such as for myopia (near-sighted), hyperopia (far-sighted), and astigmatism.
  • the lens can be aspheric and/or toric.
  • the body 12 of the lens 10 is made of an optical material, which is any material presently existing or existing in the future that is suitable for making a lens for implantation in an eye. Typically the material is polymeric.
  • the material used for the body 12 shows a change of refractive index when treated with a laser, as described in detail below.
  • Non-limiting examples of such materials include those used in the manufacture of ophthalmic devices, such as contact lenses and IOLs.
  • the present invention can be applied to siloxy-containing polymers, acrylic polymers, other hydrophilic or hydrophobic polymers, copolymers thereof, and mixtures thereof.
  • Non-limiting example of siloxy-containing polymers that can be used as optical materials are described in U.S. Pat. Nos. 6,762,271 ; 6,770,728; 6,777,522; 6,849,671 ; 6,858,218; 6,881,809; 6,908,978; 6,951,914; 7,005,494; 7,022,749; 7,033,391 ; and 7,037,954.
  • hydrophilic polymers include polymers comprising units of N-vinylpyrrolidone, 2-hydroxyethyl methacrylate, N,N-dimethylacrylamide, methacrylic acid, poly(ethylene glycol monomethacrylate), 1,4-butanediol monovinyl ether, 2-aminoethyl vinyl ether, di(ethylene glycol) monovinyl ether, ethylene glycol butyl vinyl ether, ethylene glycol monovinyl ether, glycidyl vinyl ether, glyceryl vinyl ether, vinyl carbonate, and vinyl carbamate.
  • Non-limiting examples of hydrophobic polymers include polymers comprising units of Ci-Cio alkyl methacrylates (e.g., methyl methacrylate, ethyl methacrylate, propyl methacrylate, butyl methacrylate, octyl methacrylate, or 2-ethylhexyl methacrylate;
  • Ci-Cio alkyl methacrylates e.g., methyl methacrylate, ethyl methacrylate, propyl methacrylate, butyl methacrylate, octyl methacrylate, or 2-ethylhexyl methacrylate
  • Ci-Cio alkyl acrylates e.g., methyl acrylate, ethyl acrylate, propyl acrylate, or hexyl acrylate; preferably, butyl acrylate to control mechanical properties
  • C 6 -C 40 arylalkyl acrylates e.g., 2-phenylethyl acrylate, benzyl acrylate, 3-phenylpropyl acrylate, 4-phenylbutyl acrylate, 5-phenylpentyl acrylate, 8-phenyloctyl acrylate, or 2-phenylethoxy acrylate; preferably, 2-phenylethyl acrylate to increase refractive index
  • C 6 -C 40 arylalkyl methacrylates e.g., 2- phenylethyl methacrylate, 3-phenylpropyl methacrylate, 4-phenylbutyl methacrylate, 5-
  • a preferred material is a hydrophobic acrylic polymer made from N-benzyl-N- isopropylacrylamide, ethyl methacrylate, and butyl acrylate cross linked by ethylene glycol dimethacrylate.
  • the body 12 has a diameter of about 6 mm and preferably has a thickness 20 of from about 50 ⁇ to about 1000 ⁇ , typically about 200 to about 400 ⁇ and most preferably about 250 ⁇ . This is a smaller thickness than with
  • conventional IOLs When the lens 10 is folded to be placed in the posterior chamber, because of its relative thinness, it is possible for a surgeon to make a smaller incision than with conventional lenses. This can increase safety for the patient, and it is believed can result in reduced post-operative recovery time, and reduced surgically induced astigmatism. Also in the version of the invention where the anterior and posterior surfaces are planar, it is easy to insert the lens, thereby rendering some instances of cataract surgery less traumatic. Typical diopters are in the range of -10 to +40.
  • the optical effect provided by the lens 10 is a result of the presence of modified loci in the body 12, where the modified loci having been formed by a laser beam that causes the modified loci to have a different refractive index than the lens material before modification.
  • Fig. 2 shows a portion of an exemplary lens body 12 having two spaced apart planar layers generally parallel to the anterior surface 14 of the lens body 12, an upper layer 22 and a lower layer 23. Layers 22 and 23 are preferably 50 ⁇ in thickness. Only a portion of each layer is shown, and exemplary modified loci are shown only for the upper layer 22. Layer 22 contains exemplary contiguous modified loci 24a- 24j.
  • Each locus 24 is cylindrical shape with a diameter of about 1 ⁇ with its axis generally parallel to the optical axis 19 of the lens.
  • Each locus 24a-j contains one or more sites 26 formed by a single pulse from a laser. Each site is typically about 5 ⁇ in height, and thus the modified loci range in height from about 5 to about 50 ⁇ . As shown in Fig. 2, locus 24a contains 10 sites 26, locus 24b contains 9 sites, continuing to locus 24j which contains one site.
  • each modified locus has an optical path length of about 0.1 to about 1 wave greater than the optical path length of a non-modified locus, wherein the wavelength is with respect to light of wavelength of 555 nm.
  • modified loci there are sufficient modified loci that at least 90%, and more preferably at least 99%, of the light projected onto the anterior surface 14 of the lens 10 in a direction generally parallel to the optical axis 19 passes through at least one modified locus 24.
  • Fig. 3 shows a schematic view of the multilayered, micro- structured customized intraocular lens 10 that is membrane- shaped, exhibiting a disc-like planar appearance, with a diameter 62 of about 6 mm and a width 64 of about 500 ⁇ .
  • the refractive properties of the micro- structured customized intraocular lens are inscribed in thin layers, indicated as 66 to 88, which are typically 50 ⁇ thick.
  • a posterior layer e.g., between the posterior surface 16 and plane 69, at depth 65, is generated.
  • the layers 72, 74, 76, 78, 80, 82, 84, 86 and 88 are micro-structured accordingly.
  • Additional layers 66, 68 and 70 can be micro-structured during an in-vivo fine-tuning procedure of the refractive properties of the implanted customized intraocular lens, covering the anterior portion of the intraocular phase- shifting membrane between planes 69 and 71, having a thickness 67.
  • Each layer 66-88 contains modified loci, and typically more than 1,000,000 modified loci, and up to about 30,000,000 loci, and each layer typically is in a plane substantially parallel to the anterior surface 14 of the lens body 14.
  • Fig. 4 shows pattern of modified loci used for achieving different optical effects.
  • the layer shown in Figs. 4A and 4B provide a spherical adjustment in the amount of about +0.4 diopter. It comprises three annular rings, 402, 404, and 406 concentric with the optical axis 19 and surrounding a central region 408.
  • the modified loci are in a circular pattern concentric with the optical axis.
  • the outer edge of the outermost radius ring 402 is at r 4 , which is 3 mm from the optical axis 19, i.e., it is at the peripheral edge of the body 12.
  • the outside edge of the second ring 404, r 3 is 2.5 mm from the optical axis 19.
  • the outside edge of the third ring 406, is at r 2 which is 2 mm from the optical axis 19.
  • the central portion 408 outside edge ri is at 1.4 mm.
  • Each ring is made of plurality of contiguous modified loci wherein the number of sites in each locus increases as the locus is closer is to the optical axis 19.
  • the modified loci at the outer edge of the first ring 402 has one site, and thus a height of about 5 ⁇ , while the modified locus closest to the optical axis 19 has 10 sites, and thus is about 50 ⁇ in height.
  • the layer shown in Fig. 4C is patterned to provide an aspherical focusing effect.
  • the inner most ring 406' and the central region 408' have the same pattern as the ring 406 and the central region 408, respectively, in Fig. 4A.
  • the outer rings 402' and 404' have the modified loci reversed in that there are more sites in the modified loci farther from the optical axis 19 than there are for modified loci radially inwardly. Because r l5 r 2 , and r 3 are the same in the version shown in Fig. 4C as in 4A, the top plan schematic view of 4B is also applicable to the layout shown in Fig. 4C.
  • Fig. 4D shows a pattern for the modified loci to accommodate for astigmatism and/or toricitytaken at the horizontal meridian of the lens.
  • all the rings 402", 404", and 406", and the central region 408" decrease in height the closer the modified loci in any single ring is closer to the optical axis 19, exhibiting a defocusing effect in the horizontal meridian.
  • FIG. 4E The top planar view of the layer of Fig. 4D is shown in Fig. 4E wherein the layer shown in Fig. 4D is positioned horizontally.
  • the vertical meridian of the astigmatic connecting layer of Fig. 4D is the same as shown in Fig. 4A.
  • the horizontal meridian provides -0.4 diopter power and the vertical meridian provides +0.4 diopter power. At the 45° diagonals, there is no refraction effect.
  • Each locus has a very small diameter, on the order of about 1 ⁇ .
  • the transition from the outside of a ring to the inside of a ring need not be a steady step wise decrease in the number of sites because there can be multiple modified loci having the same number of sites adjacent to each other.
  • each ring provides a 0.1 dioptic power, and thus the lens shown in Fig. 4A provides 0.4 dioptic power.
  • the lens is made with about 100 rings, where 99 of the rings have the same general configuration of rings 402, 404, and 406 in Fig. 4A, and the center ring has the configuration of the center ring 408 shown in Fig. 4A.
  • each ring has a much smaller width than the rings in Fig. 4A.
  • Figs. 5 and 6 demonstrate the principle of a modulo-2n phase wrapping technique that can be used to characterize the present invention.
  • the formed micro structure is generated to compensate for optical path length differences within an array of neighboring rays, e.g. rays 542, 544 and 546, such that all of the contiguous individual light beams 542, 544 and 546 are in phase with each other.
  • the individual contiguous light beams 542, 544 and 546 are considered exemplary.
  • Fig. 5 the sinusoidal characteristic of a first light beam 542 and second light beam 544 are shown as a function of time. If the light beams 542 and 544 were in phase with each other, which they are not in Fig. 5, the second light beam 544 would be shown superimposed on top of the first light beam 542. As shown, however, the light beams 542 and 544 are out-of-phase relative to each other, and this difference in phase is shown as a phase shift 590.
  • the phase shift 590 can be thought of as either a difference in time or a difference in distance traveled. For instance, at the specific point in time 592, the first light beam 542 is at a certain position in free space.
  • the second light beam 544 is not at this same position until the subsequent point in time 594.
  • the first light beam 542 will go through a complete period, or cycle, of 360° (2 ⁇ radians) as it travels from the point in time 592 to a point in time 596, that the magnitude of the phase shift 590 between the first light beam 542 and the second light beam 544 is less than 2 ⁇ .
  • the point in time 592 for first light beam 542 corresponds to the point in time 598 for the third light beam 546.
  • the total phase shift 604 which exists between the first light beam 542 and the third light beam 546 is more than 2 ⁇ .
  • the total phase shift 604 actually includes a modular phase shift 500 which is equal to 2 ⁇ , and an individual phase shift 502 which is less than 2 ⁇ .
  • the total phase shift 604 between any two light beams can be expressed as the sum of a modular phase shift 500 which is equal to ⁇ 2 ⁇ , where "n" is an integer, and an individual phase shift 502, the so-called modulo 2 ⁇ phase shift, which is less than 2 ⁇ .
  • the total phase shift 604 for each light beam 544, 546 is determined by comparing it with the corresponding light beam 542 as a reference.
  • the modular phase shift 500 can then be subtracted from the total phase shift 604 to obtain the individual phase shift 502 for the particular light beam 544, 546. First, however, the total phase shift 604 is determined.
  • the individual phase shifts 502 (0 to 2 ⁇ , corresponding to 0.0 to 1.0 waves), are inscribed into the loci, amounting to 5 ⁇ to 50 ⁇ depth.
  • the local phase-shift in dependence of the distance from the pupillary axis is plotted, as imposed by the micro- structured customized intraocular lens, changing from a phase-shift of 2 ⁇ , equivalent to 1.0 waves, at the optical axis 19 is to zero at the radial position
  • the initial optical beam, impinging on a micro-structured customized intraocular lens is collimated, exhibiting individual rays with identical optical path lengths, shaping a planar optical wave.
  • a focused optical wave is generated.
  • the refractive index of the body has been modified sufficiently to change the dioptic power of the body by at least +0.5 (+0.5 to +X) or at least -0.5 (-0.5 to -Y) where X can be about 48 and Y can be about 15.
  • the layers are spaced-apart by at least one micron, and preferably by at least 5 ⁇ .
  • different layers can be formed to focus light at different focal spots.
  • Another use of multi layers is to have a single layer perform multiple optical corrections rather than have all vision corrections in a single layer.
  • a first layer provide a diopter adjustment
  • other layers provide other optical corrections such as a toric adjustment or an aspheric adjustment.
  • the first layer can provide a diopter adjustment
  • the second layer loci can provide a toric adjustment
  • a third layer can provide an aspheric adjustment.
  • the present invention uses very short laser pulses of sufficient energy tightly focused on an optical, polymeric material to form the lenses.
  • High intensity of light at the focus point causes a nonlinear absorption of photons (typically multi-photon absorption) and leads to a change in the refractive index of the material at the focus point.
  • the region of the material just outside the focal region is minimally affected by the laser light.
  • select regions of an optical, polymeric material are modified with a laser resulting in a positive change in the refractive index in these regions.
  • lenses can be formed by irradiating select regions of an optical, polymeric material with a focused, visible or near-IR laser having a pulse energy from 0.05 nJ to 1000 nJ.
  • the irradiated regions exhibit little or no scattering loss, which means that the structures formed in the irradiated regions are not clearly visible under appropriate magnification without contrast enhancement.
  • the pulse energy of the focused laser used in the method in-part depends on the type of optical material that is being irradiated, how much of a change in refractive index is desired and the type of structures one wants to imprint within the material.
  • the selected pulse energy also depends upon the scan rate at which the structures are written into the optical material. Typically, greater pulse energies are needed for greater scan rates. For example, some materials call for a pulse energy from 0.2 nJ to 100 nJ, whereas other optical materials call for a pulse energy from 0.5 nJ to 10 nJ.
  • the pulse width is preserved so that the pulse peak power is strong enough to exceed the nonlinear absorption threshold of the optical material.
  • the glass of a focusing objective used can significantly increase the pulse width due to the positive dispersion of the glass.
  • a compensation scheme is used to provide a corresponding negative dispersion that can compensate for the positive dispersion introduced by the focusing objective(s).
  • focused in this application refers to the focusing of light from a laser within an optical, polymeric material using a compensation scheme to correct for the positive dispersion introduced by the focusing objective(s).
  • the compensation scheme can include an optical arrangement selected from the group consisting of at least two prisms and at least one mirror, at least two diffraction gratings, a chirped mirror and dispersion compensating mirrors to compensate for the positive dispersion introduced by the focus objective
  • the use of the compensation scheme with the focusing objective can generate pulses with pulse energy from 0.01 nJ to 100 nJ, or from 0.01 nJ to 50 nJ, and a pulse width of from 4 fs to 200 fs. At times, it can be advantageous to generate a laser pulse with energies from 0.2 nJ to 20 nJ, and a pulse width of from 4 fs to 100 fs.
  • a laser pulse with energies from 0.2 nJ to 10 nJ and a pulse width of from 5 fs to 50 fs.
  • the laser can generate light with a wavelength in the range from violet to near- infrared radiation.
  • the wavelength of the laser is in the range from 400 nm to 1500 nm, from 400 nm to 1200 nm or from 600 nm to 900 nm.
  • Fig. 7 schematically shows a preferred apparatus 702 for forming modified loci.
  • the apparatus 702 comprises a laser 704, preferably a femtosecond laser as used in 2- photon microscopes, a control unit 706, a scanning unit 708, a holder 710 for the lens disc 12, and means 712 for moving the disc 12 in which modified loci are being formed.
  • a suitable laser is available from Calmar Laser, Inc, Sunnyvale, California.
  • Each pulse emitted by the laser can have a duration of from about 50 to about 100 femtoseconds and an energy level of at least about 0.2 nJ.
  • the laser 704 Preferably the laser 704 generates about 50 million pulses per second at a wavelength of 780 nm, a pulse length of about 50 fs, each pulse having a pulse energy of about 10 nJ, the laser being a 500 mW laser.
  • An emitted laser beam 721 is directed by a turning mirror 722 through an acustooptic modulator 724 that controls the frequency of the pulses, typically at about 50 MHz to 100 MHz repetition rate.
  • the laser beam 721 typically has a diameter of 2 mm when emitted by the laser.
  • the laser beam 721 then travels through the scanning unit 708 that spatially distributes the pulses into a manifold of beams.
  • the pattern can be a raster-scan pattern or flying spot pattern.
  • the scanning unit 708 is controlled by a computer control system 726 to provide the desired configuration of the modified loci in the disc 12.
  • the beam 721 emitted from the laser has a diameter from about 2 to about 2.5 nm.
  • the beam 721, after exiting the scanner 708, is then focused to a size suitable for forming modified loci, typically forming loci having a diameter from about 1 to about 3 ⁇ .
  • the focusing can be effected with a telescopic lens pair 742 and 744, and a microscopic objective 746, where another turning mirror 748 directs the beam from the lens pair to the microscopic objective.
  • the focusing microscope objective can be a 40 x/0.8 objective with a working distance of 3.3 mm.
  • the scanning and control unit are preferably a Heidelberg Spectralis HRA scanning unit available from Heidelberg Engineering located in Heidelberg, Germany.
  • the optics in the scanning unit allow a region having a diameter of about 150 to about 450 ⁇ to be modified without having to move either the disc 14 or the optics.
  • a single layer of 50 ⁇ thickness can be micro-structured in a region in about one minute.
  • the moving means 712 allows movement in the "z" direction for providing modified loci in different layers, and also in the "x" and "y” directions for treating different regions at the same depth.
  • the moving means 712 serves as a precise positioning system to cover the full diameter of an intraocular disk, which typically has a diameter of 6 mm.
  • the holder 710 can be a bracket, a conveyor belt with recesses sized for the lens, a tray having recesses for the lens, and any other structure that can hold the lens sufficiently stable for formation of a desired refraction pattern.
  • the moving means can be any mechanical structure, typically driven by motors, that provide movement in the x, y and z directions, i.e., three dimensional movement.
  • the motors can be stepper motors. Typically movement is up to about 10 mm/second.
  • the lens manufacturing procedure uses stepping via xyz -positioning from one scan-field (typically 450 ⁇ diameter) to the next scan-field of the 2-photon microscope (raster-scan or flying spot scan).
  • the 2-photon microscope provides the depth-scan.
  • one refractive layer can be completed within the range of the 2-photon microscope.
  • the z-positioning is provided by mechanical z-positioning, in order to provide extended reach to deeper layers in disc 14.
  • the control unit 706 can be any computer that includes storage memory, a processor, a display, and input means such as a mouse, and/or keyboard.
  • the control unit is programmed to provide the desired pattern of the modified loci in the disc 12 by providing control instructions to the scanning unit 708, and when necessary to the moving means 712.
  • FIG. 8 An exemplary program for forming a disc is shown in Fig. 8, where the beam is maintained stationary (i.e., the scanner is not used) and the target disc is moved mechanically.
  • the program commences, the user is prompted to select the desired lens in step 801.
  • the user provides the desired speed for scanning the disc 14 during the laser pulsing in step 802. Only when the computer determines this speed is a safe speed, typically 4 mm or less of travel per second, does the program accept the input in step 803.
  • the program next sets the laser to use maximal power, and prompts the user for confirmation to continue in step 804.
  • the program provides the user a last opportunity to avoid lens writing before in step 805. If the user has chosen to abort writing, the program terminates. Otherwise, the program modifies a log file in step 806 to record variables appropriate to record keeping and advances.
  • the laser begins in a position at one extreme in both the x and y directions, which constitutes the home position.
  • Each layer in a modified lens can be thought of as a stack of minilayers of a depth equal to the thickness of a site.
  • the laser advances across one dimension (e.g. x), while holding the other two (e.g. y and z) constant, thereby writing a series of sites.
  • the program begins each series by finding a grid location that constitutes the starting point of the current series in step 807. Next, the program writes that series wherever appropriate in step 808.
  • the program has scanned the laser to the outer extent of a given series, it amends the log file to reflect that the series is complete in step 809.
  • the program queries the input instructions to determine if there are subsequent series to be formed in step 810. This process continues until all series of modified loci in a given minilayer are formed. Whenever a new series needs to be prepared, the program advances the second variable (e.g. y), and resets the first dimension (e.g. x) to begin a new series 807. Once the laser has finished scanning across all grid locations of the minilayer, having considered each successively and having written the series when appropriate, the program is done with writing for that minilayer. The scanner then resets the first and second dimensions to their original positions in step 811, thereby returning the laser to its home position. The program updates the log file to show that the layer is complete in step 812.
  • the second variable e.g. y
  • the first dimension e.g. x
  • the program queries to determine if more minilayers are necessary in step 813 to achieve the user's desired lens. If more minilayers are needed, the program advances the third dimension (e.g. z) and repeats the above process, beginning with finding the first grid location for the first line of the new layer 817. If no more minilayers are necessary, the program returns the laser to its original, home position for all three dimensions in step 814, modifies the log file to reflect both that writing is complete and the system time in step 815, and terminates execution. Once a layer, which typically has from 1 to 10 minilayers is completed, then any additional layer that needs preparation can be prepared using the same process. In an optional program, the focus point of the scanner 708 can be moved in the z direction (depth) to form deeper sites. Generally all sites at the same depth are formed, and then all sites at the next depth within a layer are formed, until all the sites in a layer are completed.
  • the focus point of the scanner 708 can be moved in the z direction (depth) to form deeper sites.
  • the storage memory can be one or more devices for storing data, including readonly memory (ROM), random access memory (RAM), magnetic disk storage mediums, optical storage mediums, flash memory devices, and/or other machine -readable mediums for storing information.
  • the control can be implemented by hardware, software, firmware, middleware, microcode, or a combination thereof.
  • the program code or code segments to perform the necessary tasks can be stored in a machine-readable medium such as a storage medium or other storage(s).
  • a processor may perform the necessary tasks.
  • a code segment may represent a procedure, a function, a subprogram, a program, a routine, a subroutine, a module, a software package, a class, or a combination of instructions, data structures, or program statements.
  • a code segment may be coupled to another code segment or a hardware circuit by passing and/or receiving information, data, arguments, parameters, or memory contents. Information, arguments, parameters, data, etc. may be passed, forwarded, or transmitted through a suitable means including memory sharing, message passing, token passing, network transmission, etc.
  • an adaptive-optics module can be used to simulate the effect of a refractive correction, with regard to image clarity and depth of focus.
  • the AO-module can be composed of a phase-point compensator and an active mirror for the purpose of pre-compensating individual light beams generated by the laser 704.
  • An adapted optics device to compensate for asymmetric aberrations in a beam of light is useful for the invention described in U.S. Patent No. 7,611,244.
  • a method and apparatus for pre-compensating the refractive properties of the human with an adaptive optical feedback control is described in U.S. Patent No. 6,155,684.
  • Use of active mirrors is described in U.S. Patent No. 6,220,707.
  • Typical scan-fields in the raster scan mode amount to: 150 ⁇ field of view:
  • the laser can be used to generate light from autofluorescence of the material of the lens. Modified loci generate more fluorescence than non-modified material. If a suitable increase in emitted fluorescence light is not detected, that indicates that the process for forming the modified loci is not proceeding properly.
  • a suitable system for detecting autofluorescence is shown in Fig. 7 of copending U.S.
  • the optical effects provided by the lens 10 for any particular patient can be determined using conventional techniques for designing a lens. See for example the techniques described in U.S. Patent Nos. 5,050,981 (Roffman); 5,589,982 (Faklis); 6,626,535 (Altman); 6,413,276 (Werblin); 6,511,180 (Guirao et al); and 7,241,311 (Norrby et al). A suitable technique is also described in aforementioned copending U.S. Patent application Serial No.12/717,866. (Docket No. 19330-1).
  • an absorber for light of the laser beam wavelength can be included in the disc to reduce the amount of energy required for forming the modified loci. It is desirable to have as little energy as possible used for this purpose, because exposure to excess energy can result in a cracking or other undesirable mechanical changes in the body 12.
  • UV absorbers that can be used with the laser 704 are derivatives of benzotriozoles, such as 2-(5-chloro-2-H-benzotriazol-2-yl)-6-(l,l-dimethyl-ethyl)-4- (propyenyloxypropyl)phenol, and benzophenol derivatives, such as 3-vinyl-4- phenylazophenylamine, which is a yellow dye that absorbs at a wavelength of 390 nm.
  • the amount of UV absorber provided is at least 0.01% by weight, and up to about 1% by weight of the material used for forming the lens body 12.
  • Fig. 9 the threshold energy (I) (nJ) for achieving permanent structural change in plastic material in dependence of concentration (%) of an aromatic UV-absorber is shown.
  • the typical characteristic demonstrates a strong dependence of the threshold energy on the concentration of the UV-absorber, indicating the enhancement of the local permanent structural change with the concentration of the UV-absorber, due to the increased probability of two-photon absorption processes at 390 nm wavelength, half the wavelength of the referenced incident femtosecond laser pulses of 780 nm.
  • the local interaction of the molecules of the plastic host results in a localized, partial micro- crystallization of the plastic material, yielding an increase ⁇ of the refractive index n.
  • a threshold energy of about O.lnJ is required.
  • a threshold energy of about InJ is necessary. The stated threshold energies are based on a spotsize of about ⁇ diameter, yielding threshold laser fluences of about 0.01 J/cm 2 and 0.1 J/cm 2 , respectively.
  • Fig. 10 shows the laser-material interaction process for changing the refractive index of a plastic material with femtosecond laser pulses.
  • the change ⁇ of the refractive index is plotted as function of the pulse energy; in Fig. 10B, the change ⁇ of the refractive index is plotted as a function of the number of pulses in the focal area at a fixed pulse energy (e.g. 0.2 nJ).
  • the curve 1050 in Fig. 10A demonstrates that with increasing pulse energy from O.lnJ to 8nJ, the change ⁇ of the refractive index n is enhanced from approximately 0.1% to approximately 1.0%.
  • the threshold for the initial occurrence of a measurable change ⁇ of the refractive index n is denoted at position 1052 of the curve 1050; at a pulse energy level of approximately 8nJ, corresponding to a laser flux of approximately 0.8 J/cm 2 , the threshold for photo disruption of the plastic material is reached, resulting in collateral damage of the material and opacifications, facilitating undesirable scattering losses of the light that is transmitted through the plastic material.
  • the range of possible pulse laser energies extends over two orders of magnitude, from 0.05 nJ to 8 nJ, allowing for a safe operation of the manufacturing process which occurs at the lower end of the range, at a pulse energy of approximately 0.2 nJ.
  • the safe range for a corresponding manufacturing process extends only over close to one order of magnitude.
  • the low pulse energies which are facilitated by the incorporation of the UV- absorber, allow for an especially smooth modification of the material properties, providing an intraocular phase- shifting membrane with extremely low light scattering losses.
  • FIG. 11 the manufacturing process of an intraocular phase- shifting lens where the scanning unit 708 provides a raster-scan pattern is exemplified.
  • a stack 1170 of raster-scan minilayers 1176, 1178, 1180, 1182, 1184, 1186, 1188, 1190, 1192, and 1194 is shown in an x-(1172) and y-(1174) coordinate system and extends over a thickness 1202 of approximately 50 ⁇ , i.e., each minilayer amounts to approximately 5 ⁇ .
  • the lateral size of individual minilayers typically varies between 150 ⁇ to 450 ⁇ for x (1198) and y (1199) dimensions, allowing for a change in the overlay of laser pulses in the focal volume of ⁇ diameter per spot by a factor of ten.
  • the surface 1996 is the end of a layer.
  • FIG. 12 the manufacturing of an intraocular phase-shifting lens where the scanning unit 708 provides a layered flying spot pattern is presented.
  • the successive positioning of ten tightly spaced circular scans is shown.
  • a stack 1210 of circular scans 1216, 1218, 1220, 1222, 1224, 1226, 1228, 1230, 1232, and 1234 is shown in a x (1212) and y (1214) coordinate system and extends over a thickness 1238 of approximately 50 ⁇ , i.e., the distance between individual circular scans or minilayers amounts to approximately 5 ⁇ .
  • the diameter 1236 of the circular scans can be from as small as a few microns to approximately 450 ⁇ , so that the amount of overlay of laser pulses per resolvable spot can be changed over a wide range.
  • the speed of the sequence of spots per line can be chosen as required, by changing the length of a scan line.
  • Fig. 13 the creation of a refractive layered structure by pointwise variation of the refractive index change ⁇ is demonstrated.
  • the refractive structure is incorporated in a rectangularly shaped layer in the intraocular phase-shifting lens body 12.
  • a portion of the intraocular phase- shifting membrane device is shown, comprised of e.g., three neighboring stripes 1344, 1348, 1350, and 1384 with a width of 150 ⁇ , 300 ⁇ and 450 ⁇ , respectively.
  • the overall dimensions of the region of body 14 amount to a width 1340 of 900 ⁇ and a thickness 1342 of 50 ⁇ .
  • the densities of pulses per scan-line 1346, 1350, and 1354 amount to 10 pulses per micron, 5 pulses per micron and 3 pulses per micron, respectively, yielding a two-dimensional overlay factor of 100 pulses per spot, 25 pulses per spot and 9 pulses per spot, respectively.
  • This method for forming lenses is referred to by us as "Refractive Index Shaping” (RIS), where we use infrared femtosecond laser pulses targeting a predetermined three dimensional space within a circular disc with a diameter up to about 6 mm and height of 50-100 um located between the anterior and posterior surfaces of an IOL.
  • the resulting lens is defined by the layer or zone that has a refractive index (RI) higher than surrounding IOL lens material.
  • the power of this laser-created “lens” is determined by its geometry and A(RI ) wherein A(RI ) equals (RI of the modified zone) - (RI of the IOL material).
  • the geometry of the "lens” is determined by the pattern of laser beams hitting the targets within the disc - a process we refer red to as "to write a lens".
  • RIS speed is defined as a speed, ⁇ /second, at which the laser beam can move across the lens to change the refractive index of the treated zone. There is typically a range of RIS speeds. If the laser beam moves too slowly, slower than the RIS speed, the laser beam stays at one location for too long, and it can burn the lens polymer material. If the laser beam moves too fast, faster than the RIS speed, it does not change the refractive index of the treated area. Many factors can impact the RIS speed, such as laser power, and use of yellow dye and UV absorber as dopants.
  • the RIS speed can be increased by the addition of UV absorber and/or yellow dye.
  • Conventional IOLs contain 1% or less of UV absorbers, typically an amount sufficient to provide a 90% cutoff at about 385 nm, i.e., 90% or more of the UV light rays in the range of 200-380 nm are absorbed or bought by the UV absorber.
  • the UV absorbers typically used are substituted benzotrazoles and substituted benzophenoes.
  • the UV absorber can be acrylic derivatives of benzotriozoles and most preferably at least about 15% by weight UV absorber.
  • the polymeric body contains at least 5% by weight UV absorber, more preferably at least 10% by weight.
  • the material can be provided with a yellow dye.
  • Some manufactures of IOLs use yellow dye to block harmful blue light from entering the eye to reach the retina.
  • Conventional yellow dyes usually have an aromatic azo structure and their concentration in IOLs is generally lower than 0.5% by weight.
  • a preferred amount is at least about 100 ppm (parts per million) by weight to speed up the RIS.
  • the yellow dye concentration is at least about 150 ppm, more preferably at least about 500 ppm, and generally up to about 1000 ppm.
  • a suitable yellow dye is 3VPADPA (N-Phenyl-4-(3- Vinylphenylazo)- Aniline). This can be dissolved in ethylene glycol dimethacryalte at a concentration of about 4000 ppm and added to the monomer used for forming the lens.
  • RIS speed of at least 400 ⁇ per second can be achieved, and typically from about 100 to about 200 ⁇ per second.
  • a 500 mW laser is used with an RIS speed of at least 50 mm per second.
  • Intraocular lenses are typically inserted in a human eye by folding them and introducing them to the eye through a slit.
  • the higher levels of dye and UV absorber preferably used tend to increase the stiffness of the resulting lens. This is accommodated by proper selection of monomers, with a goal to maintain the lens to be foldable, and have a glass transition temperature (T g ) of body temperature or less, i.e., 37 °C or less, and more preferably less than room temperature, i.e., equal to or less than 20 °C. It is within the skill of the art to modify the monomers and the relative amount of monomer concentration used in forming a lens to achieve this result.
  • T g glass transition temperature
  • Substantially the same method and apparatus discussed above can be used for modifying lenses in situ. This includes intraocular lenses, corneal lenses, corneal contact lenses, and natural crystalline lenses. In most instances, the lens already has optical features, such as dioptic power, toricity and/or asphericity. This method is useful for fine tuning lenses, and provides an option to LASIK surgery.
  • the apparatus of Fig. 7 is used, except there is no need for a lens holder 710 or means 712 for moving the lens. Rather, to the extent that the field of modification provided by the focusing system covers only a portion of the lens being modified, the focusing system can be changed to focus in additional regions.
  • a layer 1410 of about 6 mm in diameter of a natural lens can be modified using the apparatus of Fig. 7.
  • the layer 1410 contains modified loci, each modified locus having from 1 to 10 sites. Typically a region of about 2 mm in diameter is modified as one scan field. Then the lens system of the apparatus of Fig. 7 is sequentially moved to modify additional regions. Each region can have one or more planes of modified loci.
  • the concept of customized lens design and in situ modification can be used to achieve customized refractive corrections in living human eyes by, for example, modifying the cornea.
  • the creation of a refractive layer in a human cornea using methods described herein can be elected. For example, assuming a refractive index alteration of 1% in collagen tissue, the exposure of a layer of 50 ⁇ thickness inside the anterior stroma of the cornea is sufficient to facilitate refractive corrections of up to +/-20 diopters.
  • a series of modified loci layer is preferably positioned from 100 ⁇ to 150 ⁇ below the cornea surface. Corrections of toric and aspheric refractive errors, as well as higher order optical aberrations, can be achieved.
  • the calculation of the required correction can be accomplished similarly to the case of customized IOL-design, by techniques well known in the art, or by the techniques described in aforementioned copending application Serial No. 12/717,866 (Attorney Docket 19330-1).
  • the in situ tissue alteration process can be facilitated by the 2-photon microscope 704, providing online procedure control, based on autofluorescence imaging of the various cornea tissues.
  • the cornea tissue In contrast to polymeric lens materials, the cornea tissue is not homogeneous.
  • the structure of the cornea can be visualized by 2-photon microscopy, utilizing a fluorescence and second harmonic generation (SHG) imaging mode.
  • SHG fluorescence and second harmonic generation
  • a layer 1410 is selected, which is positioned about 100 ⁇ below the anterior lens capsule.
  • the application for modifying lens tissue is especially suited for creating multifocalities in the presbyopic human eye to facilitate near vision or to correct myopia (nearsightedness) or hyperopia (farsightedness) and astigmatism (toricity).
  • the cornea 2000 in the human eye comprises the following sections, from its anterior surface to its posterior surface, namely pavement epithelium 2002, Bowman's layer 2004, stroma 2006, Descemet's membrane 2008, and endothelium 2010.
  • the modified layer 2012 is in the stroma and its upper surface 2014 is about 100 microns below the anterior surface 2016 of the cornea 2000.
  • the thickness of the layer is about 50 microns.
  • a preferred technique for determining the location of the anterior surface of the cornea is according to that described in co-pending application serial number 12/717,866 filed March 4, 2010.
  • the anterior surface of the cornea is illuminated with infrared light of a wavelength that can generate fluorescent light from the anterior surface of the cornea when illuminated, and the generated fluorescent light detected.
  • the infrared light has a wavelength of about 780 nm.
  • the effectiveness of the laser in modifying the cornea is dependent upon the density of the portion of the cornea being treated.
  • the same technique used for determining the location of the anterior surface of the cornea can be used for determining the density of different portions of the cornea.
  • the power provided by the laser can be varied, wherein the laser beam is provided with more energy when modifying a section of the cornea that has higher density than the amount of energy when modifying a section with lower density. For example about 3% more energy can be used for the higher density areas.
  • a differential interference contrast (DIC) microscope was used to determine the effective RIS speed range.
  • DIC differential interference contrast
  • the effective RIS speed was in the range of 5 ⁇ /second to 75 ⁇ /second.
  • the RIS speed was slower than 5 ⁇ /second, the laser beam stayed at the same spot for too long, consequently burning the material. If the RIS speed was greater than 75 ⁇ m/second, the laser was ineffective in changing the refractive index of the material.
  • Example 1 The protocol of Example 1 was repeated, except the laser energy was varied from lOmW, to 20 mW, to 40mW; the amount of yellow dye was changed from 150 ppm by weight, to 500 ppm, to 1000 ppm, and the amount of UV absorber was changed from 0.8% by weight to 4% by weight.
  • the results are shown in Figs. 16 and 17. As shown in Fig 16, when the laser energy doubled from 20 mW to 40 mW, the high RIS speed limit increased approximately 8 times for all three test materials.
  • RIS speed increased as well as shown in Fig. 16. All materials in Fig 16 contained the same amount of UV absorber (0.8%).
  • Example 3 (forming polymeric body with extra UV absorber.) Polymeric material with 8% of UV absorber amount was successfully prepared as follows: In a round bottom flask equipped with a magnetic stirring bar, were added 20.15 grams of BPA (N-Benzyl-N-isopropylacrylamide); 11.4 grams of UV absorber UVAM (2-(5-Chloro-2H-benzotriazol-2-yl)-6-(l,l-dimethylethyl)-4-ethenylphenol); 0.18 grams of AIBN (2,2-Azobisisobutyronitrile); 30.88 grams of EMA (Ethyl Methacrylate); 5.20 grams of yellow dye solution (not pure yellow dye); 2.18 grams of a crosslinker, EDGMA (Ethylene Glycol Dimethacrylate); and 73.75 grams of BA (Butyl Acrylate).
  • BPA N-Benzyl-N-isopropylacrylamide
  • UVAM (2-(5-Chloro-2H
  • the yellow dye solution consisted of 3VPADPA (N-Phenyl-4-(3-Vinylphenylazo)- Aniline) in EGDMA (Ethylene Glycol Dimethacrylate) with a concentration of 4000 ppm.
  • 3VPADPA N-Phenyl-4-(3-Vinylphenylazo)- Aniline
  • EGDMA Ethylene Glycol Dimethacrylate
  • buttons were extracted in alcohol and then dried in vacuum over before it is lathed into IOLs.
  • the glass transition temperature (Tg) of a non-crystalline material which is what IOLs typically are formed from, is the critical temperature at which the material changes its behavior from being 'glassy' to being 'rubbery'.
  • 'Glassy' in this context means hard and brittle, and therefore relatively easy to break, while 'rubbery' means elastic and flexible.
  • Tg glass transition temperature is the temperature at which a polymer material changes from a glassy state (being rigid and brittle) to elastic state (being rubbery and flexible).
  • Tg refers to the value obtained with ASTM D3418-99 Standard Test Method for transition temperature of polymers by Differential Scanning Calorimetry.

Abstract

A lens for placement in a human eye, such as an intraocular lens, has at least some of its optical properties modified with a laser. The lens preferably contains at least 5% by weight UV absorber so commercially feasible rates of manufacture can be achieved. The laser forms modified loci in the lens where the modified loci have a different refractive index than the refractive index of the material before modification. The same laser modification technique can be used on the cornea in situ.

Description

SYSTEM FOR FORMING AND MODIFYING LENSES
AND LENSES FORMED THEREBY
By Josef Bille and Stephen Q. Zhou
CROSS-REFERENCE
This application claims priority from U.S. Patent Application Serial number 12/717886 filed March 4, 2010, PCT Patent Application No. PCT/US 10/26280 filed March 4, 2010, U.S. Patent Application Serial Number 12/717,866 filed March 4, 2010 and PCT Patent Application No. PCT/US 10/26281 filed March 4, 2010. These applications are incorporated herein by this reference. To the extent the following description is inconsistent with the disclosures of these applications, the following description controls.
BACKGROUND
Lenses are implanted in eyes to improve vision. In general there are two types of intraocular lenses. One type replaces the eye's natural lens, usually to replace a cataractous lens. The other type is used to supplement an existing lens and functions as a permanent corrective lens. Replacement type of lenses are implanted in the posterior chamber. A supplemental type of lens, referred to as a phakic IOL (intraocular lens), is implanted in the anterior or posterior chamber to correct refractive errors of the eye.
There are two common techniques used for forming intraocular lenses. One technique is molding, where an optical polymeric material is formed into a desired shape having a predetermined dioptic power. These lenses are available in standard diopter powers, typically differing in about 0.5 diopter power. A problem with the molding technique is it is a very expensive way to make a customized lens, and thus for most patients, only an approximate approach to clear vision is obtained. For some patients the diopter power can be wrong by 0.25 or more. Moreover, such lenses generally are not as effective for patients who have an abnormally shaped cornea, including some that have undergone a cornea procedure, such as LAS IK surgery.
The other technique used is lathing and milling, where a disc shaped lens blank is ground to a desired shape. Due to the properties of the materials used for intraocular lenses, it is preferable to machine lenses at a reduced temperature such as -10° F. A problem with lathing and milling is that the optical properties of a lens at -10° F may be different than the optical properties of the lens at body temperature, and thus such a lens only approximates optimal vision. In addition, as the lens warms it absorbs moisture and dimensions of the lens may change, thus altering the diopter power of the lens.
For some patients, it is desirable that the lenses be aspheric to correct corneal spherical aberrations or toric to correct or mitigate corneal astigmatism over a range of diopters. Commercially available IO Ls generally cannot uniformly correct these optical defects because it would be necessary to inventory hundreds, if not thousands, of different types of lenses, all varying in dioptic power, and aspheric and toric features.
Another problem associated with conventional manufacturing techniques is that the lens often cannot accommodate the needs of patients that have undergone a LASIK (laser assisted in situ keratomileusis) surgery. LASIK surgery can correct for myopia, hyperopia, and/or astigmatism. However, alterations in the cornea created in the LASIK procedure make it very difficult to find an IOL with the appropriate adjustment for asphericity. A conventional IOL is generally not satisfactory for patients that have undergone a LASIK procedure or with an abnormal cornea, because of the challenge in inventorying IOLs suitable for such a patient.
A technique for modifying the refractive index of an optical polymeric material such as in an IOL is discussed in Knox et al., U.S. Publication No. 2008/0001320. This technique uses a laser for changing the refractive index of small areas of an optical material, resulting in changes in refractive index of up to about 0.06, which is an inadequate change in diopter power for most applications.
Accordingly, there is a need for a system for forming intraocular lenses that overcomes the disadvantages of prior art manufacturing techniques, and also allows for customization of lenses to provide multiple corrective features to approach optimum vision, including for patients that have had a LASIK procedure. SUMMARY
The present invention provides a system that meets this need, and also provides lenses formed and modified by this system. A lens formed by this system has unique properties. The lenses typically are IOLs, but the invention has other applications, as discussed below. A lens according to this invention comprises a body formed of an optical material having a refractive index. The body has opposed anterior and posterior surfaces, and an optical axis. The body contains modified loci. The modified loci have been formed by a laser beam and have a different refractive index than the material before modification.
The optical properties of a polymeric lens sized for placement in a human eye is modified by modifying loci of the lens with a laser beam so the modified loci have a different refractive index than the material before modification. Preferably the laser beam travels at rate of at least 50 mm per second, but typically at a rate of no more than about 200 mm per second.
To achieve this fast rate of modification, it is desirable to dope the lens with sufficient UV absorber and/or yellow dye. Thus the lens can contain at least 5% by weight UV absorber and with at least 150 ppm by weight of yellow dye. The amount of yellow dye is preferably at least about 500 ppm by weight, and can be up to about 1000 ppm by weight. It is desirable that the lens has a glass transition temperature equal to or less than 37 °C, and more preferably less than about 20 °C, so it can be folded for insertion into the human eye.
The laser system can also be used for modifying at least one optical property of the cornea in situ in the human eye by modifying loci in the cornea with a laser beam, the modified loci have a different refractive index than before modification. The modified loci are in a planar layer substantially parallel to the anterior surface of the cornea. The layer has an upper surface about 100 microns below the anterior surface of the cornea. The layer typically is about 50 microns thick. DRAWINGS
These and other features, aspects, and advantages of the present invention will become better understood with regard to the following description, appended claims, and accompanying drawings where:
Fig. 1A is a front elevation view of an intraocular lens having features of the present invention;
Fig. IB is a top plan view of the lens of Fig. 1 A;
Fig. 2 schematically shows a portion of the body of an intraocular lens having two layers of modified loci;
Fig. 3 schematically shows a lens body having multiple layers of modified loci, where some of the layers are formed after placement of the lens in an eye;
Fig. 4A is a schematic view of one layer of the lens of Fig. 1 modified to generate a spherical focusing effect;
Fig. 4B is a top plan view of the layer shown in Fig. 4A;
Fig. 4C is a schematic view of a layer of the lens of Fig. 1 modified to generate an aspherical focusing effect;
Fig. 4D is a schematic view of a layer of the lens of Fig. 1 providing a defocusing meridian to accommodate for astigmatism;
Fig. 4E is a schematic top plan view of the layer of the lens of Fig. 4D at the horizontal meridian;
Figs. 5 and 6 schematically show the principles utilized for forming the modified loci;
Fig. 7 schematically shows the layout of an apparatus according to the present invention for forming the aforementioned lenses;
Fig. 8 shows a flow chart for an algorithm useful in the apparatus of Fig. 7;
Fig. 9 graphically shows the effect of including a UV absorber in material used for forming a lens;
Fig. 10A graphically shows the relationship between the change of the index of refraction of modified loci as a function of laser pulse energy; Fig. 10B graphically shows the relationship between the change in refractive index of a modified lens as a function of the number of laser beam pulses at a fixed pulse energy;
Fig. 11 schematically represents forming a lens according to the present invention using a layered raster- scan method;
Fig. 12 schematically represents forming a lens according to the present invention using a layered flying spot scanning method;
Fig. 13 schematically shows a process for creating a refractive layer structure by point wise variation of a change in refractive index;
Fig. 14 schematically shows how a natural lens can be modified in situ;
Fig. 15 schematically shows a modified layer in the human cornea; and
Figs. 16 and 17 graphically show the results of experiments.
DESCRIPTION
OVERVIEW
Customized intraocular lens, referred to as a Customized Intraocular Phase Shifting Membrane (C-IPSM), is manufactured using a laser unit that generates a pulsed laser beam. More specifically, a laser unit optionally can generate laser beam pulses at 50 MHz, with each pulse having duration of about 100 femtoseconds and an energy level of about 0.2 to about one nanojoule. As envisioned for the present invention, the focal spot of the laser beam is moved over a surface of plastic material having a refractive index "n0". This alters a sub-surface layer by creating a pattern of changes in the refractive index of the material (Δη).
Preferably, the customized intraocular lens (C-IPSM) is fabricated from a flat sheet of plastic that has a first side and a second side, and a thickness of from about 50 to about 400 mm between the two sides. During the manufacture of the customized intraocular lens (C-IPSM), the laser unit alters a sub-surface layer having a depth of only about 50 microns. The purpose of the layer of altered material in the layer is to compensate for optical aberrations of the patient to receive the C-IPSM. Specifically, this compensates for optical aberrations introduced into a light beam by an optical system (e.g. an eye).
The pattern of refractive index changes created in the plastic sheet results from exposing the plastic material to the electronic disruption and heat created by the layer in a predetermined manner. In particular, this change in refractive index is accomplished by sequentially focusing a laser beam onto a plethora of contiguous loci in the material. The result at each locus is an Optical Path Difference (OPD) for light passing through the spot. For a given material (e.g. plastic), having a given change in refractive index (Δη) (e.g. Δη = 0.01), and for a given distance through the material (e.g. 5 microns), an OPD (i.e. phase change) for light of a wavelength (λ) can be established. In particular, an OPD of λ/10 can be established for each 5 microns of locus depth. Thus, depending on the required refraction for each spot, the spot depth will be between 5 and 50 microns.
The amount of change in refractive index (Δη) can be altered for different locus positions, e.g. between a lowest value of Δη = 0.001 to a highest value of Δη = 0.01. Thus, depending on the required refraction, a value between Δη = 0.001 and Δη = 0.01 can be used, exploiting a modulo 2π phase wrapping technique.
Each locus can be created with the laser unit using a predetermined number of laser bursts (i.e. an "i" number of bursts). Preferably, each burst includes approximately 50 pulses and is approximately 1 microsecond in duration. During each burst, an alteration of a substantially cylindrical volume of material occurs through a depth of approximately five microns with a diameter of about one micron. Thus a locus contains at least one site, and typically up to 10 sites. In general, each burst causes an OPD of about one-tenth of a wavelength (λ/10). For "i" bursts: OPD = ί(χ(λ/10)). Preferably, for the present invention there is approximately a λ/10 change for every 5 microns of locus depth (i.e. "i" is in a range of 1 to 10). For example, consider a situation wherein it is desired to create an OPD of 0.3λ. In this case the laser unit is focused for an initial burst at a depth of twenty microns (i.e. i = 3). Thereafter, the laser unit is refocused onto the locus two more times, with the focal point of the laser beam being withdrawn each time through a distance of five microns for each subsequent burst. The number "i" is selected depending on the amount of refraction that is desired at the locus (e.g. 0.2λ for i = 2; and 0.7λ for i = 7). A locus can be created by advancing, rather than withdrawing, the focal point of the laser beam.
In accordance with another version of the invention, employing variations of Δη, each locus is created with the laser unit using a varying number of pulses per laser burst. Each laser burst creates a site, there being from 1 to 10 sites per locus. Preferably, each burst includes between 5 pulses and 50 pulses and is approximately 100 nanoseconds to 1 microsecond in duration. During each burst, an alteration of a substantially cylindrical volume of material occurs through a depth of approximately five microns with a diameter of about one micron. In general, as mentioned above, each burst causes an OPD of about one-hundreds of a wavelength (λ/100) to one-tenth of a wavelength (λ/10). Thus, by maintaining a certain number of pulses per burst per spot, for example 5 pulses, on each subsequent location for one particular spot, a predetermined OPD, in this example one- tenth of a wavelength (λ/10), resulting from (10 x (λ/100)), is obtained. Variations in OPD are incurred via the change in Δη from locus to locus, as the femtosecond laser beam is moved in a transverse direction, i.e. parallel to the surface of the plastic membrane.
Once the refractive properties desired for the customized intraocular lens (C- IPSM) are determined, a template of the anterior surface layer of the intraocular lens is calculated. This information is then sent to a manufacturing station and used for programming the individual pixels of the layers of the intraocular lens. Subsequently, after implantation of this customized intraocular lens, incoming light is refracted by the optical components in the pseudophakic eye to form an improved image on the retina of the eye.
The refraction of an incoming beam by the customized intraocular lens (C-IPSM) makes the optical path lengths of individual beams in any incoming beam appear to be substantially equal to each other. In this way, an incoming beam which carries the image information, is compensated by the customized intraocular lens (C-IPSM) to account for the refractive aberrations of the pseudophakic eye that are evidenced by the appropriate measurement data. With regard to the optical performance of the micro- structured surface layer of the customized intraocular lens (C-IPSM), several refractive and diffractive optical principles can be employed for different modifications of the performance of the customized intraocular lens (C-IPSM). The designs comprise refractive, with or without phase wrapping, and diffractive phase ("GRIN") structures. Spherical, aspherical, achromatic, bifocal and multifocal embodiments are possible.
LENSES
Lenses having features of the present invention can be of any type of lens implanted in the eye, including contact lenses, intraocular lenses placed in the anterior or posterior chamber, and corneal lenses. IOLs placed in the posterior chamber often can be phakic when the natural crystalline lens is present and pseudophakic where the natural crystalline lens has been removed such as by cataract surgery. The invention is also useful for modifying lenses in situ, including lenses such as contact lenses in the anterior chamber, IOLs in the posterior chamber or anterior chamber, the natural cornea and natural crystalline lenses.
With regard to Figs. 1A and IB, an intraocular lens 10 having features of the present invention comprises a central disc shaped body 12 having an anterior surface 14 and a posterior surface 16. Preferably both the anterior surface 14 and posterior surface 16 are substantially planar, i.e., they have little or no curvature such as concave or convex curvature. Use of the techniques of the present invention allows a plano-plano intraocular lens to be formed. As is conventional with many intraocular lenses, there can be a pair of haptics 18 for holding the lens in the posterior chamber.
The terms "anterior" and "posterior" refer to surfaces of a lens as it is normally placed in the human eye, with the anterior surface 14 facing outwardly, and the posterior surface 16 facing inwardly toward the retina. The lens 10 has an optical axis 19, which is an imaginary line that defines the path along which light propagates through the lens 10. In a version of the invention shown in Figs. 1A and IB, the optical axis 19 is coincident with the lens's mechanical axis, but this is not required. Although it is preferred that all of the optical effects of the lens be provided by modified locus in the body 12, as described below, it is possible that corrective optical effects can also be provided in the conventional way, such as by having the anterior surface, the posterior surface, or both curved, such as convex, concave, or complex curvature. It is not necessary that all optical corrections be provided by modified loci according to the present invention, although that is the preferred.
A lens having features of the present invention can be used for correcting vision errors, such as for myopia (near-sighted), hyperopia (far-sighted), and astigmatism. The lens can be aspheric and/or toric.
The body 12 of the lens 10 is made of an optical material, which is any material presently existing or existing in the future that is suitable for making a lens for implantation in an eye. Typically the material is polymeric. The material used for the body 12 shows a change of refractive index when treated with a laser, as described in detail below.
Non-limiting examples of such materials include those used in the manufacture of ophthalmic devices, such as contact lenses and IOLs. For example, the present invention can be applied to siloxy-containing polymers, acrylic polymers, other hydrophilic or hydrophobic polymers, copolymers thereof, and mixtures thereof.
Non-limiting example of siloxy-containing polymers that can be used as optical materials are described in U.S. Pat. Nos. 6,762,271 ; 6,770,728; 6,777,522; 6,849,671 ; 6,858,218; 6,881,809; 6,908,978; 6,951,914; 7,005,494; 7,022,749; 7,033,391 ; and 7,037,954.
Non-limiting examples of hydrophilic polymers include polymers comprising units of N-vinylpyrrolidone, 2-hydroxyethyl methacrylate, N,N-dimethylacrylamide, methacrylic acid, poly(ethylene glycol monomethacrylate), 1,4-butanediol monovinyl ether, 2-aminoethyl vinyl ether, di(ethylene glycol) monovinyl ether, ethylene glycol butyl vinyl ether, ethylene glycol monovinyl ether, glycidyl vinyl ether, glyceryl vinyl ether, vinyl carbonate, and vinyl carbamate.
Non-limiting examples of hydrophobic polymers include polymers comprising units of Ci-Cio alkyl methacrylates (e.g., methyl methacrylate, ethyl methacrylate, propyl methacrylate, butyl methacrylate, octyl methacrylate, or 2-ethylhexyl methacrylate;
preferably, methyl methacrylate to control mechanical properties), Ci-Cio alkyl acrylates (e.g., methyl acrylate, ethyl acrylate, propyl acrylate, or hexyl acrylate; preferably, butyl acrylate to control mechanical properties), C6-C40 arylalkyl acrylates (e.g., 2-phenylethyl acrylate, benzyl acrylate, 3-phenylpropyl acrylate, 4-phenylbutyl acrylate, 5-phenylpentyl acrylate, 8-phenyloctyl acrylate, or 2-phenylethoxy acrylate; preferably, 2-phenylethyl acrylate to increase refractive index), and C6-C40 arylalkyl methacrylates (e.g., 2- phenylethyl methacrylate, 3-phenylpropyl methacrylate, 4-phenylbutyl methacrylate, 5- phenylpentyl methacrylate, 8-phenyloctyl methacrylate, 2-phenoxyethyl methacrylate, 3,3-diphenylpropyl methacrylate, 2-(l-naphthylethyl)methacrylate, benzyl methacrylate, or 2-(2-naphthylethyl)methacrylate; preferably, 2-phenylethyl methacrylate to increase refractive index).
A preferred material is a hydrophobic acrylic polymer made from N-benzyl-N- isopropylacrylamide, ethyl methacrylate, and butyl acrylate cross linked by ethylene glycol dimethacrylate.
For a typical IOL, the body 12 has a diameter of about 6 mm and preferably has a thickness 20 of from about 50 μιη to about 1000 μιη, typically about 200 to about 400 μιη and most preferably about 250 μιη. This is a smaller thickness than with
conventional IOLs. When the lens 10 is folded to be placed in the posterior chamber, because of its relative thinness, it is possible for a surgeon to make a smaller incision than with conventional lenses. This can increase safety for the patient, and it is believed can result in reduced post-operative recovery time, and reduced surgically induced astigmatism. Also in the version of the invention where the anterior and posterior surfaces are planar, it is easy to insert the lens, thereby rendering some instances of cataract surgery less traumatic. Typical diopters are in the range of -10 to +40.
The optical effect provided by the lens 10 is a result of the presence of modified loci in the body 12, where the modified loci having been formed by a laser beam that causes the modified loci to have a different refractive index than the lens material before modification. Fig. 2 shows a portion of an exemplary lens body 12 having two spaced apart planar layers generally parallel to the anterior surface 14 of the lens body 12, an upper layer 22 and a lower layer 23. Layers 22 and 23 are preferably 50 μιη in thickness. Only a portion of each layer is shown, and exemplary modified loci are shown only for the upper layer 22. Layer 22 contains exemplary contiguous modified loci 24a- 24j. Each locus 24 is cylindrical shape with a diameter of about 1 μιη with its axis generally parallel to the optical axis 19 of the lens. Each locus 24a-j contains one or more sites 26 formed by a single pulse from a laser. Each site is typically about 5 μιη in height, and thus the modified loci range in height from about 5 to about 50 μιη. As shown in Fig. 2, locus 24a contains 10 sites 26, locus 24b contains 9 sites, continuing to locus 24j which contains one site.
The change in refractive index of the material present in the modified loci results in a change in the optical path length. In particular, the optical path length of each modified locus is increased by about 0.1 wave as compared to the optical path length of a non-modified locus, with respect to light of a selected wavelength. Generally green light having a wavelength of about 555 nm is the basis for modification since the light of that wavelength is typically optimally received by the human eye. Thus each modified locus has an optical path length of about 0.1 to about 1 wave greater than the optical path length of a non-modified locus, wherein the wavelength is with respect to light of wavelength of 555 nm.
Preferably there are sufficient modified loci that at least 90%, and more preferably at least 99%, of the light projected onto the anterior surface 14 of the lens 10 in a direction generally parallel to the optical axis 19 passes through at least one modified locus 24.
Fig. 3 shows a schematic view of the multilayered, micro- structured customized intraocular lens 10 that is membrane- shaped, exhibiting a disc-like planar appearance, with a diameter 62 of about 6 mm and a width 64 of about 500 μιη. The refractive properties of the micro- structured customized intraocular lens are inscribed in thin layers, indicated as 66 to 88, which are typically 50 μιη thick. Initially, a posterior layer, e.g., between the posterior surface 16 and plane 69, at depth 65, is generated. The layers 72, 74, 76, 78, 80, 82, 84, 86 and 88 are micro-structured accordingly. Additional layers 66, 68 and 70 can be micro-structured during an in-vivo fine-tuning procedure of the refractive properties of the implanted customized intraocular lens, covering the anterior portion of the intraocular phase- shifting membrane between planes 69 and 71, having a thickness 67.
Each layer 66-88 contains modified loci, and typically more than 1,000,000 modified loci, and up to about 30,000,000 loci, and each layer typically is in a plane substantially parallel to the anterior surface 14 of the lens body 14.
Fig. 4 shows pattern of modified loci used for achieving different optical effects. The layer shown in Figs. 4A and 4B provide a spherical adjustment in the amount of about +0.4 diopter. It comprises three annular rings, 402, 404, and 406 concentric with the optical axis 19 and surrounding a central region 408. Thus the modified loci are in a circular pattern concentric with the optical axis. The outer edge of the outermost radius ring 402 is at r4, which is 3 mm from the optical axis 19, i.e., it is at the peripheral edge of the body 12. The outside edge of the second ring 404, r3, is 2.5 mm from the optical axis 19. The outside edge of the third ring 406, is at r2 which is 2 mm from the optical axis 19. The central portion 408 outside edge ri is at 1.4 mm. Each ring is made of plurality of contiguous modified loci wherein the number of sites in each locus increases as the locus is closer is to the optical axis 19. Thus the modified loci at the outer edge of the first ring 402 has one site, and thus a height of about 5 μιη, while the modified locus closest to the optical axis 19 has 10 sites, and thus is about 50 μιη in height.
The layer shown in Fig. 4C is patterned to provide an aspherical focusing effect. In this layer, the inner most ring 406' and the central region 408' have the same pattern as the ring 406 and the central region 408, respectively, in Fig. 4A. However, the outer rings 402' and 404' have the modified loci reversed in that there are more sites in the modified loci farther from the optical axis 19 than there are for modified loci radially inwardly. Because rl5 r2, and r3 are the same in the version shown in Fig. 4C as in 4A, the top plan schematic view of 4B is also applicable to the layout shown in Fig. 4C.
Fig. 4D shows a pattern for the modified loci to accommodate for astigmatism and/or toricitytaken at the horizontal meridian of the lens. In this version, all the rings 402", 404", and 406", and the central region 408" decrease in height the closer the modified loci in any single ring is closer to the optical axis 19, exhibiting a defocusing effect in the horizontal meridian.
The top planar view of the layer of Fig. 4D is shown in Fig. 4E wherein the layer shown in Fig. 4D is positioned horizontally. The vertical meridian of the astigmatic connecting layer of Fig. 4D is the same as shown in Fig. 4A. The horizontal meridian provides -0.4 diopter power and the vertical meridian provides +0.4 diopter power. At the 45° diagonals, there is no refraction effect.
There are smooth transitions between the various regions of the layer depicted.
Each locus has a very small diameter, on the order of about 1 μιη. The transition from the outside of a ring to the inside of a ring need not be a steady step wise decrease in the number of sites because there can be multiple modified loci having the same number of sites adjacent to each other.
The optical effect provided by the lens 10 can be easily increased or decreased by changing the number of rings. For example, with the lens schematically shown in Fig. 4A, each ring provides a 0.1 dioptic power, and thus the lens shown in Fig. 4A provides 0.4 dioptic power. To make a lens having a 10 dioptic power, where each ring contributes 0.1 diopter, the lens is made with about 100 rings, where 99 of the rings have the same general configuration of rings 402, 404, and 406 in Fig. 4A, and the center ring has the configuration of the center ring 408 shown in Fig. 4A. However, since there are more rings in the same surface area, each ring has a much smaller width than the rings in Fig. 4A.
Figs. 5 and 6 demonstrate the principle of a modulo-2n phase wrapping technique that can be used to characterize the present invention. Specifically, the formed micro structure is generated to compensate for optical path length differences within an array of neighboring rays, e.g. rays 542, 544 and 546, such that all of the contiguous individual light beams 542, 544 and 546 are in phase with each other. For the discussion here, the individual contiguous light beams 542, 544 and 546 are considered exemplary.
In Fig. 5, the sinusoidal characteristic of a first light beam 542 and second light beam 544 are shown as a function of time. If the light beams 542 and 544 were in phase with each other, which they are not in Fig. 5, the second light beam 544 would be shown superimposed on top of the first light beam 542. As shown, however, the light beams 542 and 544 are out-of-phase relative to each other, and this difference in phase is shown as a phase shift 590. Conceptually, the phase shift 590 can be thought of as either a difference in time or a difference in distance traveled. For instance, at the specific point in time 592, the first light beam 542 is at a certain position in free space. Due to the phase shift 590, however, the second light beam 544 is not at this same position until the subsequent point in time 594. For the situation shown in Fig. 5, and when considering that the first light beam 542 will go through a complete period, or cycle, of 360° (2π radians) as it travels from the point in time 592 to a point in time 596, that the magnitude of the phase shift 590 between the first light beam 542 and the second light beam 544 is less than 2π.
With regard to the first light beam 542 and a third light beam 546 depicted in Fig. 6, the point in time 592 for first light beam 542 corresponds to the point in time 598 for the third light beam 546. Thus, the total phase shift 604 which exists between the first light beam 542 and the third light beam 546 is more than 2π. As contemplated, for the present invention, the total phase shift 604 actually includes a modular phase shift 500 which is equal to 2π, and an individual phase shift 502 which is less than 2π. Using this notation, the total phase shift 604 between any two light beams can be expressed as the sum of a modular phase shift 500 which is equal to η2π, where "n" is an integer, and an individual phase shift 502, the so-called modulo 2π phase shift, which is less than 2π. Thus, the integer "n" may take on different values (e.g., 0, 1, 2, 3, ...) and, specifically, for the light beam 544 (Fig. 3A) n = 0, while for the light beam 546 (Fig. 3B) n = 1. In all cases, the total phase shift 604 for each light beam 544, 546, is determined by comparing it with the corresponding light beam 542 as a reference. The modular phase shift 500 can then be subtracted from the total phase shift 604 to obtain the individual phase shift 502 for the particular light beam 544, 546. First, however, the total phase shift 604 is determined.
Referring to Fig. 4A, at each locus the modular phase shift 500 (= ηχ2π) is subtracted from the total phase shift 604, to yield the individual phase shift 502, e.g. in Fig. 4A, the modular phase shift 500 amounts to 0 x 2π = 0 in the center zone, 1 x 2π in the second zone (ri to r2), 2 x 2π = 4π in the third zone (r2 to r3) and 3 x 2π = 6π in the fourth zone (r3 to r4). The individual phase shifts 502 (0 to 2π, corresponding to 0.0 to 1.0 waves), are inscribed into the loci, amounting to 5μιη to 50μιη depth.
Thus, with further reference to Fig. 4A the local phase-shift in dependence of the distance from the pupillary axis is plotted, as imposed by the micro- structured customized intraocular lens, changing from a phase-shift of 2π, equivalent to 1.0 waves, at the optical axis 19 is to zero at the radial position It is assumed, that the initial optical beam, impinging on a micro-structured customized intraocular lens is collimated, exhibiting individual rays with identical optical path lengths, shaping a planar optical wave. As a result of the travel of the individual rays through the micro- structured customized intraocular lens, a focused optical wave is generated. In the center part of the optical beam, inside an area limited by the radius rl5 the optical phase shift changes quadratically with respect to the distance from the optical axis. At position rl5 a phase- shift of zero, equivalent to 0.0 waves, is implemented. The adjacent ray, laterally from radius rl5 is subjected to a phase-shift of 2π, equivalent to 1.0 waves, resulting in the characteristic phase-jumps of 2π, equivalent to 1.0 waves, at the zone boundaries of a modulo 2π phase wrapping technique. With regard to Fig.5, such phase jumps by an amount of 2π, respectively a multiple of 2π ("shift 500") can be visualized as "catching the next wave" which is delayed by one full cycle 2π, as related to the adjacent light beam. In general, at each of the radial positions rl5 r3, r4, the local phase-shift jumps by 2π, corresponding to 1.0 waves, whereas in between these jumps the phase changes quadratically, from a value of 2π equivalent to 1.0 waves, to zero, equivalent of 0.0 waves.
Generally there are sufficient modified loci that the refractive index of the body has been modified sufficiently to change the dioptic power of the body by at least +0.5 (+0.5 to +X) or at least -0.5 (-0.5 to -Y) where X can be about 48 and Y can be about 15.
In the multilayer versions of the invention, typically the layers are spaced-apart by at least one micron, and preferably by at least 5 μιη. In the multilayer version, it is possible to optimize the various layers for a particular selected wavelength of light. For example, a first layer can be optimized for the light of a first wavelength, such as green, the second layer for light of a second wavelength, which differs from the first wavelength by at least 50 nm, such as red light, and a third layer can be optimized for light of a third wavelength that differs from both the first and second by at least 50nm, such as blue light.
Also different layers can be formed to focus light at different focal spots.
Another use of multi layers is to have a single layer perform multiple optical corrections rather than have all vision corrections in a single layer. Thus it is possible to have a first layer provide a diopter adjustment, and other layers provide other optical corrections such as a toric adjustment or an aspheric adjustment. Thus the first layer can provide a diopter adjustment, the second layer loci can provide a toric adjustment, and a third layer can provide an aspheric adjustment.
SYSTEM FOR MAKING AND MODIFYING LENSES
The present invention uses very short laser pulses of sufficient energy tightly focused on an optical, polymeric material to form the lenses. High intensity of light at the focus point causes a nonlinear absorption of photons (typically multi-photon absorption) and leads to a change in the refractive index of the material at the focus point. The region of the material just outside the focal region is minimally affected by the laser light.
Accordingly, select regions of an optical, polymeric material are modified with a laser resulting in a positive change in the refractive index in these regions.
Thus lenses can be formed by irradiating select regions of an optical, polymeric material with a focused, visible or near-IR laser having a pulse energy from 0.05 nJ to 1000 nJ. The irradiated regions exhibit little or no scattering loss, which means that the structures formed in the irradiated regions are not clearly visible under appropriate magnification without contrast enhancement.
The pulse energy of the focused laser used in the method in-part depends on the type of optical material that is being irradiated, how much of a change in refractive index is desired and the type of structures one wants to imprint within the material. The selected pulse energy also depends upon the scan rate at which the structures are written into the optical material. Typically, greater pulse energies are needed for greater scan rates. For example, some materials call for a pulse energy from 0.2 nJ to 100 nJ, whereas other optical materials call for a pulse energy from 0.5 nJ to 10 nJ.
The pulse width is preserved so that the pulse peak power is strong enough to exceed the nonlinear absorption threshold of the optical material. However, the glass of a focusing objective used can significantly increase the pulse width due to the positive dispersion of the glass. A compensation scheme is used to provide a corresponding negative dispersion that can compensate for the positive dispersion introduced by the focusing objective(s). Accordingly, the term "focused" in this application refers to the focusing of light from a laser within an optical, polymeric material using a compensation scheme to correct for the positive dispersion introduced by the focusing objective(s). The compensation scheme can include an optical arrangement selected from the group consisting of at least two prisms and at least one mirror, at least two diffraction gratings, a chirped mirror and dispersion compensating mirrors to compensate for the positive dispersion introduced by the focus objective
The use of the compensation scheme with the focusing objective can generate pulses with pulse energy from 0.01 nJ to 100 nJ, or from 0.01 nJ to 50 nJ, and a pulse width of from 4 fs to 200 fs. At times, it can be advantageous to generate a laser pulse with energies from 0.2 nJ to 20 nJ, and a pulse width of from 4 fs to 100 fs.
Alternatively, it can be advantageous to generate a laser pulse with energies from 0.2 nJ to 10 nJ and a pulse width of from 5 fs to 50 fs.
The laser can generate light with a wavelength in the range from violet to near- infrared radiation. In various embodiments, the wavelength of the laser is in the range from 400 nm to 1500 nm, from 400 nm to 1200 nm or from 600 nm to 900 nm.
Fig. 7 schematically shows a preferred apparatus 702 for forming modified loci. The apparatus 702 comprises a laser 704, preferably a femtosecond laser as used in 2- photon microscopes, a control unit 706, a scanning unit 708, a holder 710 for the lens disc 12, and means 712 for moving the disc 12 in which modified loci are being formed. A suitable laser is available from Calmar Laser, Inc, Sunnyvale, California. Each pulse emitted by the laser can have a duration of from about 50 to about 100 femtoseconds and an energy level of at least about 0.2 nJ. Preferably the laser 704 generates about 50 million pulses per second at a wavelength of 780 nm, a pulse length of about 50 fs, each pulse having a pulse energy of about 10 nJ, the laser being a 500 mW laser. An emitted laser beam 721 is directed by a turning mirror 722 through an acustooptic modulator 724 that controls the frequency of the pulses, typically at about 50 MHz to 100 MHz repetition rate. The laser beam 721 typically has a diameter of 2 mm when emitted by the laser. The laser beam 721 then travels through the scanning unit 708 that spatially distributes the pulses into a manifold of beams. The pattern can be a raster-scan pattern or flying spot pattern. The scanning unit 708 is controlled by a computer control system 726 to provide the desired configuration of the modified loci in the disc 12.
The beam 721 emitted from the laser has a diameter from about 2 to about 2.5 nm. The beam 721, after exiting the scanner 708, is then focused to a size suitable for forming modified loci, typically forming loci having a diameter from about 1 to about 3 μιη. The focusing can be effected with a telescopic lens pair 742 and 744, and a microscopic objective 746, where another turning mirror 748 directs the beam from the lens pair to the microscopic objective. The focusing microscope objective can be a 40 x/0.8 objective with a working distance of 3.3 mm. The scanning and control unit are preferably a Heidelberg Spectralis HRA scanning unit available from Heidelberg Engineering located in Heidelberg, Germany.
The optics in the scanning unit allow a region having a diameter of about 150 to about 450 μιη to be modified without having to move either the disc 14 or the optics. Typically, a single layer of 50μιη thickness can be micro-structured in a region in about one minute.
To modify other regions of the disc 12 it is necessary to move the holder 710 with the moving means 712. The moving means 712 allows movement in the "z" direction for providing modified loci in different layers, and also in the "x" and "y" directions for treating different regions at the same depth. The moving means 712 serves as a precise positioning system to cover the full diameter of an intraocular disk, which typically has a diameter of 6 mm. The holder 710 can be a bracket, a conveyor belt with recesses sized for the lens, a tray having recesses for the lens, and any other structure that can hold the lens sufficiently stable for formation of a desired refraction pattern.
The moving means can be any mechanical structure, typically driven by motors, that provide movement in the x, y and z directions, i.e., three dimensional movement. The motors can be stepper motors. Typically movement is up to about 10 mm/second.
The lens manufacturing procedure uses stepping via xyz -positioning from one scan-field (typically 450 μιη diameter) to the next scan-field of the 2-photon microscope (raster-scan or flying spot scan). The 2-photon microscope provides the depth-scan. Typically, one refractive layer can be completed within the range of the 2-photon microscope. Alternatively, the z-positioning is provided by mechanical z-positioning, in order to provide extended reach to deeper layers in disc 14.
The control unit 706 can be any computer that includes storage memory, a processor, a display, and input means such as a mouse, and/or keyboard. The control unit is programmed to provide the desired pattern of the modified loci in the disc 12 by providing control instructions to the scanning unit 708, and when necessary to the moving means 712.
An exemplary program for forming a disc is shown in Fig. 8, where the beam is maintained stationary (i.e., the scanner is not used) and the target disc is moved mechanically. When the program commences, the user is prompted to select the desired lens in step 801. Next, the user provides the desired speed for scanning the disc 14 during the laser pulsing in step 802. Only when the computer determines this speed is a safe speed, typically 4 mm or less of travel per second, does the program accept the input in step 803. The program next sets the laser to use maximal power, and prompts the user for confirmation to continue in step 804. At this stage the program provides the user a last opportunity to avoid lens writing before in step 805. If the user has chosen to abort writing, the program terminates. Otherwise, the program modifies a log file in step 806 to record variables appropriate to record keeping and advances.
The laser begins in a position at one extreme in both the x and y directions, which constitutes the home position. Each layer in a modified lens can be thought of as a stack of minilayers of a depth equal to the thickness of a site. On a given minilayer, the laser advances across one dimension (e.g. x), while holding the other two (e.g. y and z) constant, thereby writing a series of sites. The program begins each series by finding a grid location that constitutes the starting point of the current series in step 807. Next, the program writes that series wherever appropriate in step 808. When the program has scanned the laser to the outer extent of a given series, it amends the log file to reflect that the series is complete in step 809. The program then queries the input instructions to determine if there are subsequent series to be formed in step 810. This process continues until all series of modified loci in a given minilayer are formed. Whenever a new series needs to be prepared, the program advances the second variable (e.g. y), and resets the first dimension (e.g. x) to begin a new series 807. Once the laser has finished scanning across all grid locations of the minilayer, having considered each successively and having written the series when appropriate, the program is done with writing for that minilayer. The scanner then resets the first and second dimensions to their original positions in step 811, thereby returning the laser to its home position. The program updates the log file to show that the layer is complete in step 812.
The program then queries to determine if more minilayers are necessary in step 813 to achieve the user's desired lens. If more minilayers are needed, the program advances the third dimension (e.g. z) and repeats the above process, beginning with finding the first grid location for the first line of the new layer 817. If no more minilayers are necessary, the program returns the laser to its original, home position for all three dimensions in step 814, modifies the log file to reflect both that writing is complete and the system time in step 815, and terminates execution. Once a layer, which typically has from 1 to 10 minilayers is completed, then any additional layer that needs preparation can be prepared using the same process. In an optional program, the focus point of the scanner 708 can be moved in the z direction (depth) to form deeper sites. Generally all sites at the same depth are formed, and then all sites at the next depth within a layer are formed, until all the sites in a layer are completed.
The storage memory can be one or more devices for storing data, including readonly memory (ROM), random access memory (RAM), magnetic disk storage mediums, optical storage mediums, flash memory devices, and/or other machine -readable mediums for storing information.
The control can be implemented by hardware, software, firmware, middleware, microcode, or a combination thereof. When implemented in software, firmware, middleware or microcode, the program code or code segments to perform the necessary tasks can be stored in a machine-readable medium such as a storage medium or other storage(s). A processor may perform the necessary tasks. A code segment may represent a procedure, a function, a subprogram, a program, a routine, a subroutine, a module, a software package, a class, or a combination of instructions, data structures, or program statements. A code segment may be coupled to another code segment or a hardware circuit by passing and/or receiving information, data, arguments, parameters, or memory contents. Information, arguments, parameters, data, etc. may be passed, forwarded, or transmitted through a suitable means including memory sharing, message passing, token passing, network transmission, etc.
Optionally an adaptive-optics module (AO-module) can be used to simulate the effect of a refractive correction, with regard to image clarity and depth of focus. The AO-module can be composed of a phase-point compensator and an active mirror for the purpose of pre-compensating individual light beams generated by the laser 704. An adapted optics device to compensate for asymmetric aberrations in a beam of light is useful for the invention described in U.S. Patent No. 7,611,244. A method and apparatus for pre-compensating the refractive properties of the human with an adaptive optical feedback control is described in U.S. Patent No. 6,155,684. Use of active mirrors is described in U.S. Patent No. 6,220,707.
The optical resolution (Axy, Δζ) for a two-photon signal amounts to: 2 Axy = 2χ(0.325λ)/(ΝΑ0.91) = 622nm (l/e2 diameter), Δζ = 2x0.532 xl/(n-Vn2-NA2) =
3102nm (NA=Numerical Aperture, e.g. 0.8). This yields a site size.
Typical scan-fields in the raster scan mode amount to: 150μιη field of view:
1536x1536 pixels at 5 Hz or 786x786 pixels at 10 Hz; 300μιη field of view: 1536x1536 pixels at 5 Hz or786x786 pixels at 9 Hz; 450μιη field of view: 1536x1536 pixels at 5 Hz or 786x786 pixels at 9 Hz. For quality control while forming the modified loci, the laser can be used to generate light from autofluorescence of the material of the lens. Modified loci generate more fluorescence than non-modified material. If a suitable increase in emitted fluorescence light is not detected, that indicates that the process for forming the modified loci is not proceeding properly. A suitable system for detecting autofluorescence is shown in Fig. 7 of copending U.S. Patent application serial number 12/717,866 filed on March 4, 2010 entitled "System for Characterizing A Cornea And Obtaining An Ophthalmic Lens". (Attorney docket 19330-1). Also, the autofluorescence detected can be used for positioning the focal point of the system of the laser beam from the microscope objective 746 for forming additional loci, using detected modified loci has a reference position.
The optical effects provided by the lens 10 for any particular patient can be determined using conventional techniques for designing a lens. See for example the techniques described in U.S. Patent Nos. 5,050,981 (Roffman); 5,589,982 (Faklis); 6,626,535 (Altman); 6,413,276 (Werblin); 6,511,180 (Guirao et al); and 7,241,311 (Norrby et al). A suitable technique is also described in aforementioned copending U.S. Patent application Serial No.12/717,866. (Docket No. 19330-1).
Optionally an absorber for light of the laser beam wavelength can be included in the disc to reduce the amount of energy required for forming the modified loci. It is desirable to have as little energy as possible used for this purpose, because exposure to excess energy can result in a cracking or other undesirable mechanical changes in the body 12. Exemplary of UV absorbers that can be used with the laser 704 are derivatives of benzotriozoles, such as 2-(5-chloro-2-H-benzotriazol-2-yl)-6-(l,l-dimethyl-ethyl)-4- (propyenyloxypropyl)phenol, and benzophenol derivatives, such as 3-vinyl-4- phenylazophenylamine, which is a yellow dye that absorbs at a wavelength of 390 nm. Preferably the amount of UV absorber provided is at least 0.01% by weight, and up to about 1% by weight of the material used for forming the lens body 12.
In Fig. 9, the threshold energy (I) (nJ) for achieving permanent structural change in plastic material in dependence of concentration (%) of an aromatic UV-absorber is shown. The typical characteristic demonstrates a strong dependence of the threshold energy on the concentration of the UV-absorber, indicating the enhancement of the local permanent structural change with the concentration of the UV-absorber, due to the increased probability of two-photon absorption processes at 390 nm wavelength, half the wavelength of the referenced incident femtosecond laser pulses of 780 nm. The local interaction of the molecules of the plastic host results in a localized, partial micro- crystallization of the plastic material, yielding an increase Δη of the refractive index n. At a concentration of 0.8% of the UV-absorber, as used in commercial intraocular lens materials, a threshold energy of about O.lnJ is required. In contrast, in undoped, bulk plastic material, a threshold energy of about InJ is necessary. The stated threshold energies are based on a spotsize of about Ιμιη diameter, yielding threshold laser fluences of about 0.01 J/cm2 and 0.1 J/cm2, respectively.
Fig. 10 shows the laser-material interaction process for changing the refractive index of a plastic material with femtosecond laser pulses. In Fig. 10A, the change Δη of the refractive index is plotted as function of the pulse energy; in Fig. 10B, the change Δη of the refractive index is plotted as a function of the number of pulses in the focal area at a fixed pulse energy (e.g. 0.2 nJ). The curve 1050 in Fig. 10A demonstrates that with increasing pulse energy from O.lnJ to 8nJ, the change Δη of the refractive index n is enhanced from approximately 0.1% to approximately 1.0%. The threshold for the initial occurrence of a measurable change Δη of the refractive index n is denoted at position 1052 of the curve 1050; at a pulse energy level of approximately 8nJ, corresponding to a laser flux of approximately 0.8 J/cm2, the threshold for photo disruption of the plastic material is reached, resulting in collateral damage of the material and opacifications, facilitating undesirable scattering losses of the light that is transmitted through the plastic material. As can be seen from curve 1050, the range of possible pulse laser energies extends over two orders of magnitude, from 0.05 nJ to 8 nJ, allowing for a safe operation of the manufacturing process which occurs at the lower end of the range, at a pulse energy of approximately 0.2 nJ. In undoped plastic material, the safe range for a corresponding manufacturing process extends only over close to one order of magnitude. In addition, the low pulse energies, which are facilitated by the incorporation of the UV- absorber, allow for an especially smooth modification of the material properties, providing an intraocular phase- shifting membrane with extremely low light scattering losses. In Fig. 10B, the curve 1060 indicates that the cumulative effect of approximately 50 laser pulses in the focal volume yields refractive index changes Δη of the order 1%, sufficient for achieving a optical path length difference (OPD = (Δη) x thickness) of 1.0 waves in a plastic material layer of 50μιη thickness, choosing a low pulse energy of 0.2nJ.
In Fig. 11, the manufacturing process of an intraocular phase- shifting lens where the scanning unit 708 provides a raster-scan pattern is exemplified. A procedure exhibiting the successive positioning of ten adjacent minilayers, each field comprising a densely spaced raster scan pattern is demonstrated. A stack 1170 of raster-scan minilayers 1176, 1178, 1180, 1182, 1184, 1186, 1188, 1190, 1192, and 1194 is shown in an x-(1172) and y-(1174) coordinate system and extends over a thickness 1202 of approximately 50 μιη, i.e., each minilayer amounts to approximately 5μιη. The lateral size of individual minilayers typically varies between 150 μιη to 450 μιη for x (1198) and y (1199) dimensions, allowing for a change in the overlay of laser pulses in the focal volume of Ιμτη diameter per spot by a factor of ten. The surface 1996 is the end of a layer.
In Fig. 12, the manufacturing of an intraocular phase-shifting lens where the scanning unit 708 provides a layered flying spot pattern is presented. As an example, the successive positioning of ten tightly spaced circular scans is shown. A stack 1210 of circular scans 1216, 1218, 1220, 1222, 1224, 1226, 1228, 1230, 1232, and 1234 is shown in a x (1212) and y (1214) coordinate system and extends over a thickness 1238 of approximately 50 μιη, i.e., the distance between individual circular scans or minilayers amounts to approximately 5 μιη. The diameter 1236 of the circular scans can be from as small as a few microns to approximately 450 μιη, so that the amount of overlay of laser pulses per resolvable spot can be changed over a wide range. The speed of the sequence of spots per line can be chosen as required, by changing the length of a scan line.
Individual scan lines can exhibit various shapes. The resolution of the smallest scan details can comply with the resolution limit of the two-photon microscope of
approximately Ιμιη diameter, whereas the raster scan procedure, as described with regard to Fig. 11, is limited to a resolution of approximately 150 μιη, as given by the smallest raster scan fields of a two-photon microscope. For practical applications, the
manufacturing process of intraocular phase-shifting membrane is accomplished by the dual scan-system in a complimentary fashion: The bulk part of the process is performed with the time-optimal raster scan method, whereas the fine details of the required refractive properties are contributed by the flying spot scanner with its inherent high spatial resolution.
In Fig. 13, the creation of a refractive layered structure by pointwise variation of the refractive index change Δη is demonstrated. In general, the refractive structure is incorporated in a rectangularly shaped layer in the intraocular phase-shifting lens body 12. In Fig. 13, a portion of the intraocular phase- shifting membrane device is shown, comprised of e.g., three neighboring stripes 1344, 1348, 1350, and 1384 with a width of 150μιη, 300 μιη and 450 μιη, respectively. The overall dimensions of the region of body 14 amount to a width 1340 of 900 μιη and a thickness 1342 of 50 μιη. Since the standard number of pixels per scan line in x- and y-directions is chosen as 1536 X 1536 pixels, the densities of pulses per scan-line 1346, 1350, and 1354 amount to 10 pulses per micron, 5 pulses per micron and 3 pulses per micron, respectively, yielding a two-dimensional overlay factor of 100 pulses per spot, 25 pulses per spot and 9 pulses per spot, respectively.
This method for forming lenses is referred to by us as "Refractive Index Shaping" (RIS), where we use infrared femtosecond laser pulses targeting a predetermined three dimensional space within a circular disc with a diameter up to about 6 mm and height of 50-100 um located between the anterior and posterior surfaces of an IOL. The resulting lens is defined by the layer or zone that has a refractive index (RI) higher than surrounding IOL lens material. The power of this laser-created "lens" is determined by its geometry and A(RI ) wherein A(RI ) equals (RI of the modified zone) - (RI of the IOL material). The geometry of the "lens" is determined by the pattern of laser beams hitting the targets within the disc - a process we refer red to as "to write a lens".
The term "RIS speed" is defined as a speed, μητ/second, at which the laser beam can move across the lens to change the refractive index of the treated zone. There is typically a range of RIS speeds. If the laser beam moves too slowly, slower than the RIS speed, the laser beam stays at one location for too long, and it can burn the lens polymer material. If the laser beam moves too fast, faster than the RIS speed, it does not change the refractive index of the treated area. Many factors can impact the RIS speed, such as laser power, and use of yellow dye and UV absorber as dopants.
The RIS speed can be increased by the addition of UV absorber and/or yellow dye. Conventional IOLs contain 1% or less of UV absorbers, typically an amount sufficient to provide a 90% cutoff at about 385 nm, i.e., 90% or more of the UV light rays in the range of 200-380 nm are absorbed or bought by the UV absorber. The UV absorbers typically used are substituted benzotrazoles and substituted benzophenoes. The UV absorber can be acrylic derivatives of benzotriozoles and most preferably at least about 15% by weight UV absorber. Preferably, to increase the RIS, the polymeric body contains at least 5% by weight UV absorber, more preferably at least 10% by weight.
Also the material can be provided with a yellow dye. Some manufactures of IOLs use yellow dye to block harmful blue light from entering the eye to reach the retina. Conventional yellow dyes usually have an aromatic azo structure and their concentration in IOLs is generally lower than 0.5% by weight. A preferred amount is at least about 100 ppm (parts per million) by weight to speed up the RIS. Preferably the yellow dye concentration is at least about 150 ppm, more preferably at least about 500 ppm, and generally up to about 1000 ppm. A suitable yellow dye is 3VPADPA (N-Phenyl-4-(3- Vinylphenylazo)- Aniline). This can be dissolved in ethylene glycol dimethacryalte at a concentration of about 4000 ppm and added to the monomer used for forming the lens.
With these amounts of yellow dye and UV absorber, using a 40 mW (milliwatt) laser, RIS speed of at least 400 μιη per second can be achieved, and typically from about 100 to about 200 μιη per second. Preferably a 500 mW laser is used with an RIS speed of at least 50 mm per second.
Intraocular lenses are typically inserted in a human eye by folding them and introducing them to the eye through a slit. The higher levels of dye and UV absorber preferably used tend to increase the stiffness of the resulting lens. This is accommodated by proper selection of monomers, with a goal to maintain the lens to be foldable, and have a glass transition temperature (Tg) of body temperature or less, i.e., 37 °C or less, and more preferably less than room temperature, i.e., equal to or less than 20 °C. It is within the skill of the art to modify the monomers and the relative amount of monomer concentration used in forming a lens to achieve this result.
IN SITU MODIFICATION
Substantially the same method and apparatus discussed above can be used for modifying lenses in situ. This includes intraocular lenses, corneal lenses, corneal contact lenses, and natural crystalline lenses. In most instances, the lens already has optical features, such as dioptic power, toricity and/or asphericity. This method is useful for fine tuning lenses, and provides an option to LASIK surgery.
For an in situ modification, the apparatus of Fig. 7 is used, except there is no need for a lens holder 710 or means 712 for moving the lens. Rather, to the extent that the field of modification provided by the focusing system covers only a portion of the lens being modified, the focusing system can be changed to focus in additional regions. With reference to Fig. 14 a layer 1410 of about 6 mm in diameter of a natural lens can be modified using the apparatus of Fig. 7. The layer 1410 contains modified loci, each modified locus having from 1 to 10 sites. Typically a region of about 2 mm in diameter is modified as one scan field. Then the lens system of the apparatus of Fig. 7 is sequentially moved to modify additional regions. Each region can have one or more planes of modified loci.
The concept of customized lens design and in situ modification can be used to achieve customized refractive corrections in living human eyes by, for example, modifying the cornea. The creation of a refractive layer in a human cornea using methods described herein can be elected. For example, assuming a refractive index alteration of 1% in collagen tissue, the exposure of a layer of 50μιη thickness inside the anterior stroma of the cornea is sufficient to facilitate refractive corrections of up to +/-20 diopters. A series of modified loci layer is preferably positioned from 100 μιη to 150 μιη below the cornea surface. Corrections of toric and aspheric refractive errors, as well as higher order optical aberrations, can be achieved. The calculation of the required correction can be accomplished similarly to the case of customized IOL-design, by techniques well known in the art, or by the techniques described in aforementioned copending application Serial No. 12/717,866 (Attorney Docket 19330-1). The in situ tissue alteration process can be facilitated by the 2-photon microscope 704, providing online procedure control, based on autofluorescence imaging of the various cornea tissues.
In contrast to polymeric lens materials, the cornea tissue is not homogeneous. The structure of the cornea can be visualized by 2-photon microscopy, utilizing a fluorescence and second harmonic generation (SHG) imaging mode.
In Fig.14, the creation of a refractive layer inside the anterior part of a human crystalline lens is depicted. Preferably, a layer 1410 is selected, which is positioned about 100 μιη below the anterior lens capsule. The application for modifying lens tissue is especially suited for creating multifocalities in the presbyopic human eye to facilitate near vision or to correct myopia (nearsightedness) or hyperopia (farsightedness) and astigmatism (toricity).
With reference to Fig. 15, the cornea 2000 in the human eye comprises the following sections, from its anterior surface to its posterior surface, namely pavement epithelium 2002, Bowman's layer 2004, stroma 2006, Descemet's membrane 2008, and endothelium 2010. The modified layer 2012 is in the stroma and its upper surface 2014 is about 100 microns below the anterior surface 2016 of the cornea 2000. Preferably the thickness of the layer is about 50 microns. To effectively modify the cornea, it is desirable to know exactly where the anterior surface of the cornea is located. A preferred technique for determining the location of the anterior surface of the cornea is according to that described in co-pending application serial number 12/717,866 filed March 4, 2010. In particular the anterior surface of the cornea is illuminated with infrared light of a wavelength that can generate fluorescent light from the anterior surface of the cornea when illuminated, and the generated fluorescent light detected. Typically the infrared light has a wavelength of about 780 nm.
The effectiveness of the laser in modifying the cornea is dependent upon the density of the portion of the cornea being treated. The same technique used for determining the location of the anterior surface of the cornea can be used for determining the density of different portions of the cornea. Once that is determined, the power provided by the laser can be varied, wherein the laser beam is provided with more energy when modifying a section of the cornea that has higher density than the amount of energy when modifying a section with lower density. For example about 3% more energy can be used for the higher density areas.
Example 1 (Standard Lens)
A differential interference contrast (DIC) microscope was used to determine the effective RIS speed range. For a standard Aaren's hydrophobic acrylic IOL (Aaren Scientific Inc.; 150 ppm yellow dye) with a 40 mW laser, the effective RIS speed was in the range of 5 μιη/second to 75 μιη /second. As was observed through the DIC microscope, if the RIS speed was slower than 5 μιη /second, the laser beam stayed at the same spot for too long, consequently burning the material. If the RIS speed was greater than 75 μm/second, the laser was ineffective in changing the refractive index of the material.
Example 2 (Effect of varying laser power, yellow dye, and UV absorber)
The protocol of Example 1 was repeated, except the laser energy was varied from lOmW, to 20 mW, to 40mW; the amount of yellow dye was changed from 150 ppm by weight, to 500 ppm, to 1000 ppm, and the amount of UV absorber was changed from 0.8% by weight to 4% by weight. The results are shown in Figs. 16 and 17. As shown in Fig 16, when the laser energy doubled from 20 mW to 40 mW, the high RIS speed limit increased approximately 8 times for all three test materials.
As the yellow dye concentration increased from 150 ppm to 500 ppm and to 1000 ppm, RIS speed increased as well as shown in Fig. 16. All materials in Fig 16 contained the same amount of UV absorber (0.8%).
The increase in the UV absorber percentage in the IOL increased the RIS speed, even more effectively than the yellow dye, as shown in Fig. 17.
Example 3 (forming polymeric body with extra UV absorber.) Polymeric material with 8% of UV absorber amount was successfully prepared as follows: In a round bottom flask equipped with a magnetic stirring bar, were added 20.15 grams of BPA (N-Benzyl-N-isopropylacrylamide); 11.4 grams of UV absorber UVAM (2-(5-Chloro-2H-benzotriazol-2-yl)-6-(l,l-dimethylethyl)-4-ethenylphenol); 0.18 grams of AIBN (2,2-Azobisisobutyronitrile); 30.88 grams of EMA (Ethyl Methacrylate); 5.20 grams of yellow dye solution (not pure yellow dye); 2.18 grams of a crosslinker, EDGMA (Ethylene Glycol Dimethacrylate); and 73.75 grams of BA (Butyl Acrylate). The yellow dye solution consisted of 3VPADPA (N-Phenyl-4-(3-Vinylphenylazo)- Aniline) in EGDMA (Ethylene Glycol Dimethacrylate) with a concentration of 4000 ppm. After the round bottom flask was placed on a magnetic stir plate and stirred for 60 to 90 minutes, the mixture solution was transferred into glass plate molds. The molds were placed into a pre-heated convection oven at 65 °C for the curing process. Then the temperature was raised to 140°C for 8 hours before it was cooled down to 30°C.
After the sheet was removed from the glass mold, it was punched into round buttons with a diameter of 16 mm. The buttons were extracted in alcohol and then dried in vacuum over before it is lathed into IOLs.
This procedure was repeated for different concentrations of UV-absorber: for 4% UV-absorber, 5.7 grams of UVAM were added: and for 16% UV-absorber, 22.8 grams of UVAM were added.
The hardness properties were measured on a durometer and glass transition temperatures were measured by DSC. The results are presented in Table 1.
Table 1. Lens Material Hardness and Glass Transition Temperature.
UV absorber % Yellow Dye % Hardness Tg (°C)
0.8% (Standard) 150 ppm 54 11
4% 150 ppm 57 12
8% 150 ppm 60 13
16% 150 ppm 62 13
The glass transition temperature (Tg) of a non-crystalline material, which is what IOLs typically are formed from, is the critical temperature at which the material changes its behavior from being 'glassy' to being 'rubbery'. 'Glassy' in this context means hard and brittle, and therefore relatively easy to break, while 'rubbery' means elastic and flexible. Tg, glass transition temperature is the temperature at which a polymer material changes from a glassy state (being rigid and brittle) to elastic state (being rubbery and flexible). As used herein, "Tg" refers to the value obtained with ASTM D3418-99 Standard Test Method for transition temperature of polymers by Differential Scanning Calorimetry.
It is believed the in situ modification of cornea and lens tissues can eventually substitute LAS IK- surgery, refractive lens exchange (RLE) procedures, and Phakic lens procedures providing a non-invasive, patient-friendly alternative.
Although the present invention has been described in considerable detail with reference to the preferred versions thereof, other versions are possible. Therefore the scope of the appended claims should not be limited to the description of the preferred versions contained therein.

Claims

What is Claimed is:
1. A polymeric body sized for implantation in a human eye as an intraocular lens and containing at least 5% by weight UV absorber.
2. The body of claim 1 containing at least 10% by weight UV absorber.
3. The body of claim 2 comprising up to about 15% by weight UV absorber.
4. The body of claim 1 sufficiently foldable for implantation in a human eye.
5. The body of claim 1 wherein the body has at least one haptic.
6. The body of claim 1 having opposed anterior and posterior surfaces, wherein at least one of the surfaces is substantially convex or substantially concave.
7. The body of claim 1 having a glass transition temperature equal to or less than 37 °C.
8. The body of claim 7 having a glass transition temperature of less than 20
°C.
9. The body of claim 1 comprising at least about 150 ppm by weight of yellow dye.
10. The body of claim 9 comprising at least about 500 ppm by weight yellow dye.
11. The body of claim 9 comprising up to about 1000 ppm by weight of yellow dye.
12. A method for modifying the optical properties of a polymeric lens sized for placement in a human eye, the lens having an anterior surface and a posterior surface, the method comprising the step of modifying loci of the lens with a laser beam, the modified loci having a different refractive index than the material before modification, wherein the laser beam travels at a rate of at least 40 μιη per second.
13. The method of claim 12 wherein the laser beam travels at a rate of at least 50 millimeters per second.
14. The method of claim 12 wherein the lens contains at least 5% by weight UV absorber.
15. The method of claim 12 wherein the lens has a glass transition temperature equal to or less than 37 °C.
16. The method of claim 15 wherein the lens has a glass transition temperature equal to or less than 20 °C.
17. The method of claim 12 wherein the lens contains at least 150 ppm by weight of yellow dye
18. A method for modifying at least one optical property of a cornea in situ in a human eye, the cornea having an anterior surface, the method comprising the step of modifying loci in the cornea with a laser beam, the modified loci having a different refractive index than their refractive index before modification, the modified loci being in a planar layer substantially parallel to the anterior surface of the cornea, the layer having an upper surface that is about 100 microns below the anterior surface of the cornea.
19. The method of claim 18 wherein the layer is about 50 microns thick.
20. The method of claim 18 comprising, before the step of modifying, the additional step of determining the location of the anterior surface of the cornea by illuminating the anterior surface with infrared light of a wavelength that can generate fluorescent light from the anterior surface of the cornea when illuminated, and detecting the generated fluorescent light.
21. The method of claim 20 wherein the infrared light has the wavelength of about 780 nm.
22. The method of claim 18 comprising, before the step of modifying, determining the density of at least a portion of the layer.
23. The method of claim 22 wherein the step of determining the density of at least a portion of the layer comprises illuminating at least a portion of the layer with infrared light of a wavelength that can generate fluorescent light form the layer, and detecting the generated fluorescent light.
24. The method of claim 18 wherein a first portion of the layer has a first density and a second portion of the layer has a second density, the first density being larger than the second density, and wherein the step of modifying comprises having the laser beam have higher energy when modifying the first section than the energy used for modifying the second section.
25. A crosslinked polymeric body sized for implantation in a human eye as an intraocular lens, wherein the body
(a) contains sufficient UV absorber that the body has an RIS speed of at least 400 μιη/second when treated with a femtosecond infrared laser with a power of 40 mW and the UV absorber blocks 90% or more of UV light with wavelength in the range of 200 to 400 nm; and
(b) has a glass transition temperature equal to or less than 37°C.
26. The body of claim 25 containing sufficient yellow dye to block at least 50% of the visible light with a wavelength in the range of 400-480 nm.
27. The body of claim 26 containing at least 150 ppm by weight yellow dye.
28. The body of claim 25 comprising at least 5% by weight UV absorber.
29. A crosslinked polymeric body sized for implantation in a human eye as an intraocular lens, wherein the body
(a) contains sufficient UV absorber and sufficient yellow dye that the body has an RIS speed of at least 400 μιη/second when treated with a femtosecond infrared laser with a power of 40 mW, wherein the UV absorber blocks 90% or more of UV light with wavelength in the range of 200 to 400 nm, and wherein the yellow dye blocks at least 50% of the visible light with a wavelength in the range of 400-480 nm; and
(b) has a glass transition temperature equal to or less than 37°C.
30. The body of claim 29 containing at least 150 ppm by weight yellow dye.
31. The body of claim 30 comprising at least 5% by weight UV absorber.
32. The body of claim 29 comprising at least 5% by weight UV absorber.
PCT/US2010/048161 2010-03-04 2010-09-08 System for forming and modifying lenses and lenses formed thereby WO2011109039A1 (en)

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CN201080066621XA CN102883681A (en) 2010-03-04 2010-09-08 System for forming and modifying lenses and lenses formed thereby

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US12/717,886 2010-03-04
US12/717,866 US8646916B2 (en) 2009-03-04 2010-03-04 System for characterizing a cornea and obtaining an opthalmic lens
PCT/US2010/026281 WO2010102156A1 (en) 2009-03-04 2010-03-04 System for characterizing a cornea and obtaining an ophthalmic lens
PCT/US2010/026280 WO2010102155A1 (en) 2009-03-04 2010-03-04 System for forming and modifying lenses and lenses formed thereby
USPCT/US2010/026280 2010-03-04
US12/717,866 2010-03-04
USPCT/US2010/026281 2010-03-04
US12/717,886 US8292952B2 (en) 2009-03-04 2010-03-04 System for forming and modifying lenses and lenses formed thereby

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