WO2011062437A3 - 고나도트로핀 방출 호르몬 수용체 길항제, 이의 제조방법 및 이를 함유하는 약제학적 조성물 - Google Patents
고나도트로핀 방출 호르몬 수용체 길항제, 이의 제조방법 및 이를 함유하는 약제학적 조성물 Download PDFInfo
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- WO2011062437A3 WO2011062437A3 PCT/KR2010/008194 KR2010008194W WO2011062437A3 WO 2011062437 A3 WO2011062437 A3 WO 2011062437A3 KR 2010008194 W KR2010008194 W KR 2010008194W WO 2011062437 A3 WO2011062437 A3 WO 2011062437A3
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- releasing hormone
- receptor antagonists
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Abstract
본 발명은 고나도트로핀 방출 호르몬("GnRH")(황체형성 호르몬 방출 호르몬으로서도 공지됨) 수용체 길항제에 관한 것이다.
Priority Applications (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES10831804T ES2549502T3 (es) | 2009-11-20 | 2010-11-19 | Antagonistas de receptores de gonadoliberina, método de fabricación de los mismos, y composición farmacéutica que los contienen |
JP2012539815A JP5757956B2 (ja) | 2009-11-20 | 2010-11-19 | ゴナドトロピン放出ホルモン受容体拮抗剤、その製造方法及びそれを含む医薬組成物 |
EP10831804.9A EP2390250B1 (en) | 2009-11-20 | 2010-11-19 | Gonadotropin releasing hormone receptor antagonists, manufacturing method thereof, and pharmaceutical composition containing same |
US13/511,065 US9034850B2 (en) | 2009-11-20 | 2010-11-19 | Gonadotropin releasing hormone receptor antagonist, preparation method thereof and pharmaceutical composition comprising the same |
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
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KR10-2009-0112896 | 2009-11-20 | ||
KR20090112896 | 2009-11-20 | ||
KR10-2010-0115345 | 2010-11-19 | ||
KR1020100115345A KR101122606B1 (ko) | 2009-11-20 | 2010-11-19 | 고나도트로핀 방출 호르몬 수용체 길항제, 이의 제조방법 및 이를 함유하는 약제학적 조성물 |
Publications (2)
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WO2011062437A2 WO2011062437A2 (ko) | 2011-05-26 |
WO2011062437A3 true WO2011062437A3 (ko) | 2011-11-03 |
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PCT/KR2010/008194 WO2011062437A2 (ko) | 2009-11-20 | 2010-11-19 | 고나도트로핀 방출 호르몬 수용체 길항제, 이의 제조방법 및 이를 함유하는 약제학적 조성물 |
Country Status (6)
Country | Link |
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US (1) | US9034850B2 (ko) |
EP (1) | EP2390250B1 (ko) |
JP (1) | JP5757956B2 (ko) |
KR (2) | KR101122606B1 (ko) |
ES (1) | ES2549502T3 (ko) |
WO (1) | WO2011062437A2 (ko) |
Families Citing this family (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2865547C (en) * | 2012-02-28 | 2020-03-10 | Sk Chemicals Co., Ltd. | Gonadotropin releasing hormone receptor antagonists, method for the preparation thereof and pharmaceutical composition comprising the same |
US9073878B2 (en) | 2012-11-21 | 2015-07-07 | Zenith Epigenetics Corp. | Cyclic amines as bromodomain inhibitors |
WO2014080291A2 (en) | 2012-11-21 | 2014-05-30 | Rvx Therapeutics Inc. | Biaryl derivatives as bromodomain inhibitors |
MX2015007921A (es) | 2012-12-21 | 2016-03-03 | Zenith Epigenetics Corp | Compuestos heterociclicos novedosos como inhibidores de bromodominio. |
WO2015004533A2 (en) | 2013-06-21 | 2015-01-15 | Zenith Epigenetics Corp. | Novel substituted bicyclic compounds as bromodomain inhibitors |
MX365864B (es) | 2013-06-21 | 2019-06-18 | Zenith Epigenetics Ltd | Inhibidores de bromodominio biciclicos novedosos. |
WO2015015318A2 (en) | 2013-07-31 | 2015-02-05 | Zenith Epigenetics Corp. | Novel quinazolinones as bromodomain inhibitors |
US10202361B2 (en) | 2014-08-29 | 2019-02-12 | Fmc Corporation | Pyridazinones as herbicides |
US10179125B2 (en) | 2014-12-01 | 2019-01-15 | Zenith Epigenetics Ltd. | Substituted pyridines as bromodomain inhibitors |
CA2966298A1 (en) | 2014-12-01 | 2016-06-09 | Zenith Epigenetics Ltd. | Substituted pyridinones as bromodomain inhibitors |
JP2017537946A (ja) | 2014-12-11 | 2017-12-21 | ゼニス・エピジェネティクス・リミテッドZenith Epigenetics Ltd. | ブロモドメイン阻害剤としての置換複素環 |
US10231953B2 (en) | 2014-12-17 | 2019-03-19 | Zenith Epigenetics Ltd. | Inhibitors of bromodomains |
KR101973074B1 (ko) * | 2018-11-30 | 2019-04-26 | 주식회사 티움바이오 | 퓨로피리미딘 화합물의 염 및 결정형, 및 이를 포함하는 약학적 조성물 |
CN109761912A (zh) * | 2019-02-16 | 2019-05-17 | 安徽诺全药业有限公司 | 一种多取代嘧啶衍生物的合成方法 |
CN113527213B (zh) * | 2020-04-20 | 2023-01-03 | 上海英诺富成生物科技有限公司 | 促性激素释放激素受体拮抗剂及其用途 |
JP7388423B2 (ja) | 2021-12-27 | 2023-11-29 | オムロン株式会社 | 押圧治具 |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2001055119A2 (en) * | 2000-01-25 | 2001-08-02 | Neurocrine Biosciences, Inc. | Gonadotropin-releasing hormone receptor antagonists and methods relating thereto |
KR20060031851A (ko) * | 2003-07-07 | 2006-04-13 | 뉴로크린 바이오사이언시즈 인코퍼레이티드 | 고나도트로핀-방출 호르몬 수용체 길항제로서의피리미딘-2,4-디온 유도체 |
KR20060052790A (ko) * | 2003-07-07 | 2006-05-19 | 뉴로크린 바이오사이언시즈 인코퍼레이티드 | 고나도트로핀-방출 호르몬 수용체 길항제로서의피리미딘-2,4-디온 유도체 |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IE71183B1 (en) | 1988-12-27 | 1997-01-29 | Takeda Chemical Industries Ltd | Guanidine derivatives their production and insecticides |
HU214320B (hu) | 1991-12-20 | 1998-03-02 | EGIS Gyógyszergyár Rt. | Eljárás új 3(2H)-piridazinon-származékok és ezeket tartalmazó gyógyszerkészítmények előállítására |
US5756507A (en) * | 1995-12-14 | 1998-05-26 | Merck & Co., Inc. | Antagonists of gonadotropin releasing hormone |
EP1110454A3 (en) | 1999-12-16 | 2002-06-05 | Rohm And Haas Company | 5-Carboxanilido-haloalkylthiazoles as antimicrobial and marine antifouling agents |
US6673796B2 (en) * | 2001-08-02 | 2004-01-06 | Neurocrine Biosciences, Inc. | Gonadotropin-releasing hormone receptor antagonists and methods relating thereto |
WO2003013528A1 (en) * | 2001-08-02 | 2003-02-20 | Neurocrine Biosciences, Inc. | Substituted pyridin-4-ones and their use as gonadotropin-releasing hormone receptor antagonists. |
US6750350B2 (en) | 2001-08-02 | 2004-06-15 | Neurocrine Biosciences, Inc. | Gonadotropin-releasing hormone receptor antagonists and methods relating thereto |
KR100486251B1 (ko) | 2002-08-03 | 2005-05-03 | 삼성전자주식회사 | 가변 길이 코드 복호화 장치 및 방법 |
CA2694284A1 (en) | 2007-06-29 | 2009-01-08 | Jennifer Cossrow | Heterocyclic compounds useful as raf kinase inhibitors |
-
2010
- 2010-11-19 EP EP10831804.9A patent/EP2390250B1/en not_active Not-in-force
- 2010-11-19 WO PCT/KR2010/008194 patent/WO2011062437A2/ko active Application Filing
- 2010-11-19 US US13/511,065 patent/US9034850B2/en not_active Expired - Fee Related
- 2010-11-19 KR KR1020100115345A patent/KR101122606B1/ko active IP Right Grant
- 2010-11-19 ES ES10831804T patent/ES2549502T3/es active Active
- 2010-11-19 JP JP2012539815A patent/JP5757956B2/ja not_active Expired - Fee Related
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2011
- 2011-12-09 KR KR1020110132182A patent/KR20110137764A/ko not_active Application Discontinuation
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2001055119A2 (en) * | 2000-01-25 | 2001-08-02 | Neurocrine Biosciences, Inc. | Gonadotropin-releasing hormone receptor antagonists and methods relating thereto |
KR20060031851A (ko) * | 2003-07-07 | 2006-04-13 | 뉴로크린 바이오사이언시즈 인코퍼레이티드 | 고나도트로핀-방출 호르몬 수용체 길항제로서의피리미딘-2,4-디온 유도체 |
KR20060052790A (ko) * | 2003-07-07 | 2006-05-19 | 뉴로크린 바이오사이언시즈 인코퍼레이티드 | 고나도트로핀-방출 호르몬 수용체 길항제로서의피리미딘-2,4-디온 유도체 |
Non-Patent Citations (2)
Title |
---|
ROWBOTTOM, M. W. ET AL.: "Synthesis and Structure Activity Relationships of Uracil Derived Human GnRH Receptor Antagonists: (R)-3-[2-(2-Amino) phenethyl]-1-(2,6- difluorobenzyl)-6-methyluracils Containing a Substituted Thiophene or Thiazole at C-5", BIOORGANIC & MEDICINAL CHEMISTRY, vol. 14, 2004, pages 4967 - 4973, XP004548798, DOI: doi:10.1016/j.bmcl.2004.07.022 * |
See also references of EP2390250A4 * |
Also Published As
Publication number | Publication date |
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ES2549502T3 (es) | 2015-10-28 |
US9034850B2 (en) | 2015-05-19 |
EP2390250A2 (en) | 2011-11-30 |
KR101122606B1 (ko) | 2012-03-16 |
JP5757956B2 (ja) | 2015-08-05 |
EP2390250A4 (en) | 2012-08-29 |
JP2013511514A (ja) | 2013-04-04 |
EP2390250B1 (en) | 2015-08-12 |
US20130137661A1 (en) | 2013-05-30 |
KR20110137764A (ko) | 2011-12-23 |
WO2011062437A2 (ko) | 2011-05-26 |
KR20110056242A (ko) | 2011-05-26 |
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