WO2009075783A8 - System for electrical modulation of neural conduction - Google Patents

System for electrical modulation of neural conduction Download PDF

Info

Publication number
WO2009075783A8
WO2009075783A8 PCT/US2008/013407 US2008013407W WO2009075783A8 WO 2009075783 A8 WO2009075783 A8 WO 2009075783A8 US 2008013407 W US2008013407 W US 2008013407W WO 2009075783 A8 WO2009075783 A8 WO 2009075783A8
Authority
WO
WIPO (PCT)
Prior art keywords
electrical modulation
neural conduction
conduction
disclosed
methods
Prior art date
Application number
PCT/US2008/013407
Other languages
French (fr)
Other versions
WO2009075783A1 (en
Inventor
Ralph G. Dacey, Jr.
Gregory J. Della Rocca
Colin P. Derdeyn
Joshua L. Dowling
Eleanor V. Goodall
Roderick A. Hyde
Muriel Y. Ishikawa
Jordin T. Kare
Eric C. Leuthardt
Nathan P. Myhrvold
Michael A. Smith
Lowell L. Wood, Jr.
Victoria Y.H. Wood
Gregory J. Zipfel
Original Assignee
Searete Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US11/999,721 external-priority patent/US8180446B2/en
Priority claimed from US12/070,369 external-priority patent/US8165669B2/en
Priority claimed from US12/070,361 external-priority patent/US8195287B2/en
Priority claimed from US12/070,331 external-priority patent/US8170658B2/en
Application filed by Searete Llc filed Critical Searete Llc
Priority to GB1010162.4A priority Critical patent/GB2467881B/en
Publication of WO2009075783A1 publication Critical patent/WO2009075783A1/en
Publication of WO2009075783A8 publication Critical patent/WO2009075783A8/en

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00Electrotherapy; Circuits therefor
    • A61N1/18Applying electric currents by contact electrodes
    • A61N1/32Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/3605Implantable neurostimulators for stimulating central or peripheral nerve system
    • A61N1/3606Implantable neurostimulators for stimulating central or peripheral nerve system adapted for a particular treatment
    • A61N1/36071Pain
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/24Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/40Detecting, measuring or recording for evaluating the nervous system
    • A61B5/4029Detecting, measuring or recording for evaluating the nervous system for evaluating the peripheral nervous systems
    • A61B5/4041Evaluating nerves condition
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/41Detecting, measuring or recording for evaluating the immune or lymphatic systems
    • A61B5/411Detecting or monitoring allergy or intolerance reactions to an allergenic agent or substance
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00Electrotherapy; Circuits therefor
    • A61N1/18Applying electric currents by contact electrodes
    • A61N1/32Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00Electrotherapy; Circuits therefor
    • A61N1/18Applying electric currents by contact electrodes
    • A61N1/32Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/36014External stimulators, e.g. with patch electrodes
    • A61N1/36017External stimulators, e.g. with patch electrodes with leads or electrodes penetrating the skin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00Electrotherapy; Circuits therefor
    • A61N1/18Applying electric currents by contact electrodes
    • A61N1/32Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/36014External stimulators, e.g. with patch electrodes
    • A61N1/36021External stimulators, e.g. with patch electrodes for treatment of pain
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N2/00Magnetotherapy
    • A61N2/004Magnetotherapy specially adapted for a specific therapy
    • A61N2/006Magnetotherapy specially adapted for a specific therapy for magnetic stimulation of nerve tissue
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N2/00Magnetotherapy
    • A61N2/02Magnetotherapy using magnetic fields produced by coils, including single turn loops or electromagnets
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00Electrotherapy; Circuits therefor
    • A61N1/18Applying electric currents by contact electrodes
    • A61N1/32Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/362Heart stimulators
    • A61N1/365Heart stimulators controlled by a physiological parameter, e.g. heart potential
    • A61N1/36514Heart stimulators controlled by a physiological parameter, e.g. heart potential controlled by a physiological quantity other than heart potential, e.g. blood pressure
    • A61N1/36535Heart stimulators controlled by a physiological parameter, e.g. heart potential controlled by a physiological quantity other than heart potential, e.g. blood pressure controlled by body position or posture
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00Electrotherapy; Circuits therefor
    • A61N1/18Applying electric currents by contact electrodes
    • A61N1/32Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/362Heart stimulators
    • A61N1/365Heart stimulators controlled by a physiological parameter, e.g. heart potential
    • A61N1/36514Heart stimulators controlled by a physiological parameter, e.g. heart potential controlled by a physiological quantity other than heart potential, e.g. blood pressure
    • A61N1/36542Heart stimulators controlled by a physiological parameter, e.g. heart potential controlled by a physiological quantity other than heart potential, e.g. blood pressure controlled by body motion, e.g. acceleration
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00Electrotherapy; Circuits therefor
    • A61N1/40Applying electric fields by inductive or capacitive coupling ; Applying radio-frequency signals
    • A61N1/403Applying electric fields by inductive or capacitive coupling ; Applying radio-frequency signals for thermotherapy, e.g. hyperthermia

Abstract

Methods and related systems for modulating neural activity by repetitively blocking conduction in peripheral neural structures with electrical stimuli are disclosed. Methods and systems for reversing effects of blocking stimuli and/or for producing substantially permanent conduction block are also disclosed.
PCT/US2008/013407 2007-12-05 2008-12-04 System for electrical modulation of neural conduction WO2009075783A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
GB1010162.4A GB2467881B (en) 2007-12-05 2008-12-04 System for electrical modulation of neural conduction

Applications Claiming Priority (10)

Application Number Priority Date Filing Date Title
US11/999,721 US8180446B2 (en) 2007-12-05 2007-12-05 Method and system for cyclical neural modulation based on activity state
US11/999,721 2007-12-05
US12/070,369 US8165669B2 (en) 2007-12-05 2008-02-15 System for magnetic modulation of neural conduction
US12/070,361 2008-02-15
US12/070,369 2008-02-15
US12/070,331 2008-02-15
US12/070,361 US8195287B2 (en) 2007-12-05 2008-02-15 Method for electrical modulation of neural conduction
US12/070,331 US8170658B2 (en) 2007-12-05 2008-02-15 System for electrical modulation of neural conduction
US12/070,332 2008-02-15
US12/070,332 US8165668B2 (en) 2007-12-05 2008-02-15 Method for magnetic modulation of neural conduction

Publications (2)

Publication Number Publication Date
WO2009075783A1 WO2009075783A1 (en) 2009-06-18
WO2009075783A8 true WO2009075783A8 (en) 2009-09-03

Family

ID=40718064

Family Applications (2)

Application Number Title Priority Date Filing Date
PCT/US2008/013443 WO2009073223A1 (en) 2007-12-05 2008-12-04 System for magnetic modulation of neural conduction
PCT/US2008/013407 WO2009075783A1 (en) 2007-12-05 2008-12-04 System for electrical modulation of neural conduction

Family Applications Before (1)

Application Number Title Priority Date Filing Date
PCT/US2008/013443 WO2009073223A1 (en) 2007-12-05 2008-12-04 System for magnetic modulation of neural conduction

Country Status (3)

Country Link
US (1) US8165668B2 (en)
GB (2) GB2467881B (en)
WO (2) WO2009073223A1 (en)

Families Citing this family (54)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10912712B2 (en) 2004-03-25 2021-02-09 The Feinstein Institutes For Medical Research Treatment of bleeding by non-invasive stimulation
US11207518B2 (en) * 2004-12-27 2021-12-28 The Feinstein Institutes For Medical Research Treating inflammatory disorders by stimulation of the cholinergic anti-inflammatory pathway
US8391970B2 (en) * 2007-08-27 2013-03-05 The Feinstein Institute For Medical Research Devices and methods for inhibiting granulocyte activation by neural stimulation
US8170658B2 (en) 2007-12-05 2012-05-01 The Invention Science Fund I, Llc System for electrical modulation of neural conduction
US8195287B2 (en) 2007-12-05 2012-06-05 The Invention Science Fund I, Llc Method for electrical modulation of neural conduction
US20090149799A1 (en) * 2007-12-05 2009-06-11 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Method for chemical modulation of neural activity
US8180447B2 (en) 2007-12-05 2012-05-15 The Invention Science Fund I, Llc Method for reversible chemical modulation of neural activity
US8170659B2 (en) 2007-12-05 2012-05-01 The Invention Science Fund I, Llc Method for thermal modulation of neural activity
US8989858B2 (en) * 2007-12-05 2015-03-24 The Invention Science Fund I, Llc Implant system for chemical modulation of neural activity
US8180446B2 (en) 2007-12-05 2012-05-15 The Invention Science Fund I, Llc Method and system for cyclical neural modulation based on activity state
US8165668B2 (en) 2007-12-05 2012-04-24 The Invention Science Fund I, Llc Method for magnetic modulation of neural conduction
US8165669B2 (en) 2007-12-05 2012-04-24 The Invention Science Fund I, Llc System for magnetic modulation of neural conduction
US9662490B2 (en) 2008-03-31 2017-05-30 The Feinstein Institute For Medical Research Methods and systems for reducing inflammation by neuromodulation and administration of an anti-inflammatory drug
WO2009146030A1 (en) * 2008-03-31 2009-12-03 The Feinstein Institute For Medical Research Methods and systems for reducing inflammation by neuromodulation of t-cell activity
AU2009316801C1 (en) 2008-11-18 2015-12-24 Setpoint Medical Corporation Devices and methods for optimizing electrode placement for anti-inflammatory stimulation
US9211410B2 (en) 2009-05-01 2015-12-15 Setpoint Medical Corporation Extremely low duty-cycle activation of the cholinergic anti-inflammatory pathway to treat chronic inflammation
US8886339B2 (en) 2009-06-09 2014-11-11 Setpoint Medical Corporation Nerve cuff with pocket for leadless stimulator
US8788034B2 (en) 2011-05-09 2014-07-22 Setpoint Medical Corporation Single-pulse activation of the cholinergic anti-inflammatory pathway to treat chronic inflammation
US8996116B2 (en) * 2009-10-30 2015-03-31 Setpoint Medical Corporation Modulation of the cholinergic anti-inflammatory pathway to treat pain or addiction
US20110077719A1 (en) * 2009-09-30 2011-03-31 Broadcom Corporation Electromagnetic power bio-medical unit
US9833621B2 (en) 2011-09-23 2017-12-05 Setpoint Medical Corporation Modulation of sirtuins by vagus nerve stimulation
WO2014169145A1 (en) 2013-04-10 2014-10-16 Setpoint Medical Corporation Closed-loop vagus nerve stimulation
US8321012B2 (en) * 2009-12-22 2012-11-27 The Invention Science Fund I, Llc Device, method, and system for neural modulation as vaccine adjuvant in a vertebrate subject
EP3636314B1 (en) 2009-12-23 2021-09-08 Setpoint Medical Corporation Neural stimulation devices and systems for treatment of chronic inflammation
JP5806047B2 (en) 2011-08-25 2015-11-10 大学共同利用機関法人自然科学研究機構 Pain sensory nerve stimulator
US10470684B2 (en) 2012-01-26 2019-11-12 Autonomix Medical, Inc. Controlled sympathectomy and micro-ablation systems and methods
US9649064B2 (en) 2012-01-26 2017-05-16 Autonomix Medical, Inc. Controlled sympathectomy and micro-ablation systems and methods
US9572983B2 (en) 2012-03-26 2017-02-21 Setpoint Medical Corporation Devices and methods for modulation of bone erosion
BR112015017042B1 (en) 2013-01-21 2022-03-03 Cala Health, Inc Device to treat tremor
US8880167B2 (en) * 2013-02-13 2014-11-04 Flint Hills Scientific, Llc Selective recruitment and activation of fiber types in nerves for the control of undesirable brain state changes
CN105338899B (en) * 2013-06-23 2019-08-20 格鲁科威斯塔公司 The concentration measurements carried out using the cooling device with the endothermic reaction
US10758738B2 (en) 2014-03-18 2020-09-01 Case Western Reserve University Systems and methods for fast and reversible nerve block
JP6606105B2 (en) 2014-06-02 2019-11-13 カラ ヘルス,インコーポレイテッド System and method for peripheral nerve stimulation for treating tremor
US11311725B2 (en) 2014-10-24 2022-04-26 Setpoint Medical Corporation Systems and methods for stimulating and/or monitoring loci in the brain to treat inflammation and to enhance vagus nerve stimulation
US11406833B2 (en) 2015-02-03 2022-08-09 Setpoint Medical Corporation Apparatus and method for reminding, prompting, or alerting a patient with an implanted stimulator
US11103696B2 (en) 2015-05-05 2021-08-31 Cosmo Haralambidis Device for electrical stimulation of peridontal complex and surrounding tissue
CA2999710C (en) 2015-05-05 2023-09-19 Cosmo HARALAMBIDIS Device for electrical stimulation of peridontal complex and surrounding tissue
CN107847730B (en) 2015-06-10 2021-03-16 卡拉健康公司 System and method for peripheral nerve stimulation to treat tremor with a detachable treatment and monitoring unit
CN108348746B (en) 2015-09-23 2021-10-12 卡拉健康公司 System and method for peripheral nerve stimulation in fingers or hands to treat hand tremor
US10596367B2 (en) 2016-01-13 2020-03-24 Setpoint Medical Corporation Systems and methods for establishing a nerve block
US10695569B2 (en) 2016-01-20 2020-06-30 Setpoint Medical Corporation Control of vagal stimulation
US11471681B2 (en) 2016-01-20 2022-10-18 Setpoint Medical Corporation Batteryless implantable microstimulators
EP3405255A4 (en) 2016-01-20 2019-10-16 Setpoint Medical Corporation Implantable microstimulators and inductive charging systems
US11344722B2 (en) 2016-01-21 2022-05-31 Cala Health, Inc. Systems, methods and devices for peripheral neuromodulation for treating diseases related to overactive bladder
US10583304B2 (en) 2016-01-25 2020-03-10 Setpoint Medical Corporation Implantable neurostimulator having power control and thermal regulation and methods of use
IL264116B2 (en) 2016-07-08 2024-01-01 Cala Health Inc Systems and methods for stimulating n nerves with exactly n electrodes and improved dry electrodes
CA3058786A1 (en) 2017-04-03 2018-10-11 Cala Health, Inc. Systems, methods and devices for peripheral neuromodulation for treating diseases related to overactive bladder
US11173307B2 (en) 2017-08-14 2021-11-16 Setpoint Medical Corporation Vagus nerve stimulation pre-screening test
US10661082B2 (en) * 2017-10-31 2020-05-26 Nxp B.V. Noninvasive inductive biological conditioning device
EP3740274A4 (en) 2018-01-17 2021-10-27 Cala Health, Inc. Systems and methods for treating inflammatory bowel disease through peripheral nerve stimulation
CL2018001900A1 (en) * 2018-07-12 2018-10-05 Biomedical Devices Spa System and method of functional electro stimulation that allows to deliver coordinated and natural movements for people or animals with damage to the motor system
US11260229B2 (en) 2018-09-25 2022-03-01 The Feinstein Institutes For Medical Research Methods and apparatuses for reducing bleeding via coordinated trigeminal and vagal nerve stimulation
US11890468B1 (en) 2019-10-03 2024-02-06 Cala Health, Inc. Neurostimulation systems with event pattern detection and classification
EP4153053A1 (en) 2020-05-21 2023-03-29 The Feinstein Institutes for Medical Research Systems and methods for vagus nerve stimulation

Family Cites Families (199)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3841306A (en) 1972-10-25 1974-10-15 Univ Iowa State Res Found Inc Implantable, non-contacting nerve stimulating transducer
US4570640A (en) 1981-08-06 1986-02-18 Barsa John E Sensory monitoring apparatus and method
US4487603A (en) 1982-11-26 1984-12-11 Cordis Corporation Implantable microinfusion pump system
DE3490016T1 (en) 1983-01-21 1985-02-07 Ramm Associates, Creve Coeur, Mo. Implantable hyperthermia device and system
US5224928A (en) 1983-08-18 1993-07-06 Drug Delivery Systems Inc. Mounting system for transdermal drug applicator
US4889526A (en) 1984-08-27 1989-12-26 Magtech Laboratories, Inc. Non-invasive method and apparatus for modulating brain signals through an external magnetic or electric field to reduce pain
US4608985A (en) 1984-10-11 1986-09-02 Case Western Reserve University Antidromic pulse generating wave form for collision blocking
US4817628A (en) 1985-10-18 1989-04-04 David L. Zealear System and method for evaluating neurological function controlling muscular movements
US5035891A (en) 1987-10-05 1991-07-30 Syntex (U.S.A.) Inc. Controlled release subcutaneous implant
US4939149A (en) 1988-10-24 1990-07-03 The United States Of America As Represented By The Department Of Health And Human Services Resiniferatoxin and analogues thereof to cause sensory afferent C-fiber and thermoregulatory desensitization
US5057104A (en) 1989-05-30 1991-10-15 Cyrus Chess Method and apparatus for treating cutaneous vascular lesions
US5061234A (en) 1989-09-25 1991-10-29 Corteks, Inc. Magnetic neural stimulator for neurophysiology
US5031618A (en) 1990-03-07 1991-07-16 Medtronic, Inc. Position-responsive neuro stimulator
AU657681B2 (en) 1990-03-30 1995-03-23 Alza Corporation Device and method for iontophoretic drug delivery
US5092835A (en) * 1990-07-06 1992-03-03 Schurig Janet L S Brain and nerve healing power apparatus and method
US5224927A (en) 1990-11-01 1993-07-06 Robert Tapper Iontophoretic treatment system
US5188104A (en) 1991-02-01 1993-02-23 Cyberonics, Inc. Treatment of eating disorders by nerve stimulation
US5335657A (en) 1991-05-03 1994-08-09 Cyberonics, Inc. Therapeutic treatment of sleep disorder by nerve stimulation
US5251634A (en) 1991-05-03 1993-10-12 Cyberonics, Inc. Helical nerve electrode
US5192527A (en) 1991-07-01 1993-03-09 Abrahmsohn Glenn M Method of reversing local anesthesia and reagent system therefor
US5231988A (en) 1991-08-09 1993-08-03 Cyberonics, Inc. Treatment of endocrine disorders by nerve stimulation
US5354320A (en) 1991-09-12 1994-10-11 Biotronik Mess- Und Therapiegerate Gmbh & Co., Ingenieurburo Berlin Neurostimulator for production of periodic stimulation pulses
US5215089A (en) 1991-10-21 1993-06-01 Cyberonics, Inc. Electrode assembly for nerve stimulation
DE69320378T2 (en) 1992-01-21 1999-04-29 Macrochem Corp Iontophoretic improved drug delivery
US5499967A (en) 1992-02-27 1996-03-19 Societe Anonyme Dite: Laboratoires D'hygiene Societe Anonyme Dite: Et De Dietetique (L.H.D.) Transdermal drug delivery device with waveshape generator
US5330515A (en) 1992-06-17 1994-07-19 Cyberonics, Inc. Treatment of pain by vagal afferent stimulation
US5395398A (en) 1993-07-28 1995-03-07 C. R. Bard, Inc. Microelectric apparatus for the antisepsis, promulgation of healing and analgesia of wound and chronic skin ulcers
US5997501A (en) 1993-11-18 1999-12-07 Elan Corporation, Plc Intradermal drug delivery device
US6405732B1 (en) 1994-06-24 2002-06-18 Curon Medical, Inc. Method to treat gastric reflux via the detection and ablation of gastro-esophageal nerves and receptors
US5531778A (en) 1994-09-20 1996-07-02 Cyberonics, Inc. Circumneural electrode assembly
US5628769A (en) 1994-09-30 1997-05-13 Saringer Research, Inc. Method and devices for producing somatosensory stimulation using temperature
US5571150A (en) 1994-12-19 1996-11-05 Cyberonics, Inc. Treatment of patients in coma by nerve stimulation
US5458325A (en) 1994-12-27 1995-10-17 Klein; David A. Weather-resistant basketball net
US5643246A (en) 1995-02-24 1997-07-01 Gel Sciences, Inc. Electromagnetically triggered, responsive gel based drug delivery device
DE19509634C1 (en) 1995-03-17 1996-03-28 Fresenius Ag Implantable infusion pump with constant delivery rate
US5540730A (en) 1995-06-06 1996-07-30 Cyberonics, Inc. Treatment of motility disorders by nerve stimulation
US6245347B1 (en) 1995-07-28 2001-06-12 Zars, Inc. Methods and apparatus for improved administration of pharmaceutically active compounds
US5707400A (en) 1995-09-19 1998-01-13 Cyberonics, Inc. Treating refractory hypertension by nerve stimulation
US5755750A (en) 1995-11-13 1998-05-26 University Of Florida Method and apparatus for selectively inhibiting activity in nerve fibers
AU2260397A (en) 1996-01-31 1997-08-22 Trustees Of The University Of Pennsylvania, The Remote control drug delivery device
US6066163A (en) 1996-02-02 2000-05-23 John; Michael Sasha Adaptive brain stimulation method and system
US6051017A (en) 1996-02-20 2000-04-18 Advanced Bionics Corporation Implantable microstimulator and systems employing the same
CA2171067A1 (en) * 1996-03-05 1997-09-06 Brian J. Andrews Neural prosthesis
US5683422A (en) 1996-04-25 1997-11-04 Medtronic, Inc. Method and apparatus for treating neurodegenerative disorders by electrical brain stimulation
US5861022A (en) 1996-04-30 1999-01-19 Hipskind; S. Gregory Method for the treatment of hiccups
US6246912B1 (en) 1996-06-27 2001-06-12 Sherwood Services Ag Modulated high frequency tissue modification
US5797898A (en) 1996-07-02 1998-08-25 Massachusetts Institute Of Technology Microchip drug delivery devices
US7204832B2 (en) 1996-12-02 2007-04-17 Pálomar Medical Technologies, Inc. Cooling system for a photo cosmetic device
US5830208A (en) 1997-01-31 1998-11-03 Laserlite, Llc Peltier cooled apparatus and methods for dermatological treatment
US7460911B2 (en) 1997-02-26 2008-12-02 Alfred E. Mann Foundation For Scientific Research System and method suitable for treatment of a patient with a neurological deficit by sequentially stimulating neural pathways using a system of discrete implantable medical devices
US6208894B1 (en) 1997-02-26 2001-03-27 Alfred E. Mann Foundation For Scientific Research And Advanced Bionics System of implantable devices for monitoring and/or affecting body parameters
US6012457A (en) 1997-07-08 2000-01-11 The Regents Of The University Of California Device and method for forming a circumferential conduction block in a pulmonary vein
US6326020B1 (en) 1997-05-16 2001-12-04 Children's Medical Center Corporation Local anesthetic formulations
US5817139A (en) 1997-05-22 1998-10-06 Polytronics, Ltd. Skin-contact type antiallergic skin-therapeutic apparatus using voltage pulse train
US6164283A (en) 1997-07-08 2000-12-26 The Regents Of The University Of California Device and method for forming a circumferential conduction block in a pulmonary vein
US6238421B1 (en) 1997-08-15 2001-05-29 GüNTHER ROLF. W. Induction heating device and method for metallic implants in living beings
CA2306918C (en) 1997-10-17 2008-04-15 Respironics, Inc. Muscle stimulating device and method for diagnosing and treating a breathing disorder
AU754269B2 (en) 1998-01-12 2002-11-07 Ronald P. Lesser Technique for using brain heat flow management to treat brain disorders
US6364899B1 (en) 1998-01-23 2002-04-02 Innercool Therapies, Inc. Heat pipe nerve cooler
JP3732404B2 (en) 1998-02-23 2006-01-05 ニーモサイエンス ゲーエムベーハー   Shape memory polymer composition, method of forming a shape memory product, and method of forming a composition that stores a shape
US6314325B1 (en) 1998-04-07 2001-11-06 William R. Fitz Nerve hyperpolarization method and apparatus for pain relief
US6589271B1 (en) 1998-04-21 2003-07-08 Alsius Corporations Indwelling heat exchange catheter
US5993414A (en) 1998-04-23 1999-11-30 Medtronic, Inc. Implantable device
US6266556B1 (en) 1998-04-27 2001-07-24 Beth Israel Deaconess Medical Center, Inc. Method and apparatus for recording an electroencephalogram during transcranial magnetic stimulation
US6058331A (en) 1998-04-27 2000-05-02 Medtronic, Inc. Apparatus and method for treating peripheral vascular disease and organ ischemia by electrical stimulation with closed loop feedback control
US6941171B2 (en) 1998-07-06 2005-09-06 Advanced Bionics Corporation Implantable stimulator methods for treatment of incontinence and pain
US5876422A (en) 1998-07-07 1999-03-02 Vitatron Medical B.V. Pacemaker system with peltier cooling of A-V node for treating atrial fibrillation
US7209787B2 (en) 1998-08-05 2007-04-24 Bioneuronics Corporation Apparatus and method for closed-loop intracranial stimulation for optimal control of neurological disease
US7231254B2 (en) 1998-08-05 2007-06-12 Bioneuronics Corporation Closed-loop feedback-driven neuromodulation
US7324851B1 (en) 1998-08-05 2008-01-29 Neurovista Corporation Closed-loop feedback-driven neuromodulation
US7277758B2 (en) 1998-08-05 2007-10-02 Neurovista Corporation Methods and systems for predicting future symptomatology in a patient suffering from a neurological or psychiatric disorder
DK1115454T3 (en) 1998-08-31 2007-02-19 Travanti Pharma Inc Controlled dose drug delivery system
US7076307B2 (en) 2002-05-09 2006-07-11 Boveja Birinder R Method and system for modulating the vagus nerve (10th cranial nerve) with electrical pulses using implanted and external components, to provide therapy neurological and neuropsychiatric disorders
US6402739B1 (en) 1998-12-08 2002-06-11 Y-Beam Technologies, Inc. Energy application with cooling
WO2000041764A1 (en) 1999-01-11 2000-07-20 Bmr Research & Development Limited An electrotherapy device and method
US6464687B1 (en) 1999-03-09 2002-10-15 Ball Semiconductor, Inc. Implantable drug delivery system
WO2000066204A1 (en) 1999-04-30 2000-11-09 University Of Southern California Implantable microbolus infusion pump
US6796956B2 (en) 1999-04-30 2004-09-28 Medtronic, Inc. Method and apparatus to control drug therapy dosages in an implantable pump
US20020019652A1 (en) 1999-07-08 2002-02-14 Cyclotec Advanced Medical Technologies Two part tens bandage
DE60018582T2 (en) 1999-08-18 2006-01-19 Microchips, Inc., Bedford THERMALLY ACTIVATABLE MICROCHIP AS CHARGING DEVICE FOR CHEMICALS
US7113821B1 (en) 1999-08-25 2006-09-26 Johnson & Johnson Consumer Companies, Inc. Tissue electroperforation for enhanced drug delivery
US6802811B1 (en) 1999-09-17 2004-10-12 Endoluminal Therapeutics, Inc. Sensing, interrogating, storing, telemetering and responding medical implants
US6835184B1 (en) 1999-09-24 2004-12-28 Becton, Dickinson And Company Method and device for abrading skin
US6882881B1 (en) 1999-10-19 2005-04-19 The Johns Hopkins University Techniques using heat flow management, stimulation, and signal analysis to treat medical disorders
US20020173827A1 (en) 1999-11-24 2002-11-21 Jones Gary L. Apparatus and method for inducing epileptic seizures in test animals for anticonvulsant drug screening
WO2001039831A1 (en) 1999-12-06 2001-06-07 Advanced Bionics Corporation Implantable device programmer
EP1235560B1 (en) 1999-12-10 2006-04-19 Massachusetts Institute Of Technology Microchip devices for delivery of molecules and methods of fabrication thereof
US6539250B1 (en) 1999-12-15 2003-03-25 David S. Bettinger Programmable transdermal therapeutic apparatus
US6421561B1 (en) 1999-12-30 2002-07-16 Birch Point Medical, Inc. Rate adjustable drug delivery system
US6527695B1 (en) 2000-01-11 2003-03-04 Emory University Magnetic stimulation coil and circuit design
US6885888B2 (en) 2000-01-20 2005-04-26 The Cleveland Clinic Foundation Electrical stimulation of the sympathetic nerve chain
US6491061B1 (en) 2000-02-25 2002-12-10 University Of New Mexico Stimuli responsive hybrid materials containing molecular actuators and their applications
US6454759B2 (en) 2000-02-28 2002-09-24 The Regents Of The University Of California Microfabricated injectable drug delivery system
WO2001085094A2 (en) 2000-05-08 2001-11-15 Brainsgate Ltd. Method and apparatus for stimulating the sphenopalatine ganglion to modify properties of the bbb and cerebral blood flow
CA2408417C (en) 2000-05-12 2009-09-15 Novalar Pharmaceuticals, Inc. Local anesthetic methods and kits
US6660247B1 (en) 2000-06-23 2003-12-09 Battelle Memorial Institute Multiple stimulus reversible hydrogels
US7010351B2 (en) 2000-07-13 2006-03-07 Northstar Neuroscience, Inc. Methods and apparatus for effectuating a lasting change in a neural-function of a patient
IT1319170B1 (en) 2000-07-28 2003-09-26 Lorenzo Piccone APPARATUS ABLE TO MODULATE THE NEUROVEGETATIVE SYSTEM AND INTEGRATE ITS ACTION WITH THAT OF THE CENTRAL NERVOUS SYSTEM:
DE10039240A1 (en) 2000-08-11 2002-02-28 Hans Ulrich May Electrotherapeutic device
US6921413B2 (en) 2000-08-16 2005-07-26 Vanderbilt University Methods and devices for optical stimulation of neural tissues
US6871099B1 (en) 2000-08-18 2005-03-22 Advanced Bionics Corporation Fully implantable microstimulator for spinal cord stimulation as a therapy for chronic pain
US6505079B1 (en) 2000-09-13 2003-01-07 Foster Bio Technology Corp. Electrical stimulation of tissue for therapeutic and diagnostic purposes
US8086314B1 (en) 2000-09-27 2011-12-27 Cvrx, Inc. Devices and methods for cardiovascular reflex control
US6416495B1 (en) 2000-10-10 2002-07-09 Science Incorporated Implantable fluid delivery device for basal and bolus delivery of medicinal fluids
AU2002218012A1 (en) * 2000-11-14 2002-05-27 Joseph Manne Electromagnetically induced anesthesia and sensory stimulation
US6832114B1 (en) 2000-11-21 2004-12-14 Advanced Bionics Corporation Systems and methods for modulation of pancreatic endocrine secretion and treatment of diabetes
US6799149B2 (en) 2000-12-29 2004-09-28 Medtronic, Inc. Therapy management techniques for an implantable medical device
US6666845B2 (en) 2001-01-04 2003-12-23 Advanced Neuromodulation Systems, Inc. Implantable infusion pump
WO2002055058A2 (en) 2001-01-09 2002-07-18 Microchips, Inc. Flexible microchip devices for ophthalmic and other applications
US6571125B2 (en) 2001-02-12 2003-05-27 Medtronic, Inc. Drug delivery device
US7389145B2 (en) 2001-02-20 2008-06-17 Case Western Reserve University Systems and methods for reversibly blocking nerve activity
US8060208B2 (en) 2001-02-20 2011-11-15 Case Western Reserve University Action potential conduction prevention
US6453195B1 (en) 2001-03-19 2002-09-17 Medtronic, Inc. Closed loop drug delivery system and remote management thereof
US6907295B2 (en) 2001-08-31 2005-06-14 Biocontrol Medical Ltd. Electrode assembly for nerve control
US6684105B2 (en) 2001-08-31 2004-01-27 Biocontrol Medical, Ltd. Treatment of disorders by unidirectional nerve stimulation
US6761715B2 (en) 2001-04-26 2004-07-13 Ronald J. Carroll Method and device for neurocryo analgesia and anesthesia
US6928320B2 (en) 2001-05-17 2005-08-09 Medtronic, Inc. Apparatus for blocking activation of tissue or conduction of action potentials while other tissue is being therapeutically activated
US6551235B2 (en) 2001-06-28 2003-04-22 Potencia Medical Ag Implantable pump
US6629990B2 (en) 2001-07-13 2003-10-07 Ad-Tech Medical Instrument Corp. Heat-removal method and apparatus for treatment of movement disorder episodes
US6600956B2 (en) 2001-08-21 2003-07-29 Cyberonics, Inc. Circumneural electrode assembly
US7885709B2 (en) 2001-08-31 2011-02-08 Bio Control Medical (B.C.M.) Ltd. Nerve stimulation for treating disorders
US7209788B2 (en) 2001-10-29 2007-04-24 Duke University Closed loop brain machine interface
GB0129390D0 (en) 2001-12-07 2002-01-30 Clark Terrence D Electrodynamic sensors and applications thereof
AU2002244626A1 (en) 2002-02-14 2003-09-04 Infineon Technologies Ag Optoelectronic component with a peltier cooler
US7819869B2 (en) 2004-11-15 2010-10-26 Kimberly-Clark Inc. Methods of treating the sacroilac region of a patient's body
US7108680B2 (en) 2002-03-06 2006-09-19 Codman & Shurtleff, Inc. Closed-loop drug delivery system
US7340304B2 (en) 2002-03-15 2008-03-04 Biomed Soutions, Llc Biothermal power source for implantable devices
US7689277B2 (en) 2002-03-22 2010-03-30 Leptos Biomedical, Inc. Neural stimulation for treatment of metabolic syndrome and type 2 diabetes
US7236822B2 (en) 2002-03-22 2007-06-26 Leptos Biomedical, Inc. Wireless electric modulation of sympathetic nervous system
US7162303B2 (en) 2002-04-08 2007-01-09 Ardian, Inc. Renal nerve stimulation method and apparatus for treatment of patients
US8774913B2 (en) 2002-04-08 2014-07-08 Medtronic Ardian Luxembourg S.A.R.L. Methods and apparatus for intravasculary-induced neuromodulation
US6978174B2 (en) 2002-04-08 2005-12-20 Ardian, Inc. Methods and devices for renal nerve blocking
US7653438B2 (en) 2002-04-08 2010-01-26 Ardian, Inc. Methods and apparatus for renal neuromodulation
US20070135875A1 (en) 2002-04-08 2007-06-14 Ardian, Inc. Methods and apparatus for thermally-induced renal neuromodulation
JP2005526839A (en) 2002-04-23 2005-09-08 アルザ・コーポレーシヨン Transdermal analgesic system with low possibility of unauthorized use
US6745078B1 (en) 2002-04-24 2004-06-01 Kelly W. Buchner Procedure and machine for electro-inducing/stimulating deep-layered muscle contractions using a biphasic faradic pulse sequence
US6746474B2 (en) 2002-05-31 2004-06-08 Vahid Saadat Apparatus and methods for cooling a region within the body
US20040049134A1 (en) 2002-07-02 2004-03-11 Tosaya Carol A. System and methods for treatment of alzheimer's and other deposition-related disorders of the brain
US7226426B2 (en) 2002-07-25 2007-06-05 Thomson Paul E Apparatus and method for the detection and quantification of joint and tissue inflammation
US20040127886A1 (en) 2002-09-23 2004-07-01 Triton Biosystems, Inc. Stent and method for drug delivery from stents
US7204833B1 (en) 2002-10-11 2007-04-17 Flint Hills Scientific Llc Multi-modal system for detection and control of changes in brain state
AU2003301481A1 (en) 2002-10-15 2004-05-04 Medtronic Inc. Channel-selective blanking for a medical device system
US6860852B2 (en) 2002-10-25 2005-03-01 Compex Medical S.A. Ultrasound therapeutic device
US8064994B2 (en) 2003-01-14 2011-11-22 The United States Of America As Represented By The Department Of Veterans Affairs Cervical vagal stimulation induced weight loss
US20040172084A1 (en) 2003-02-03 2004-09-02 Knudson Mark B. Method and apparatus for treatment of gastro-esophageal reflux disease (GERD)
US7444183B2 (en) * 2003-02-03 2008-10-28 Enteromedics, Inc. Intraluminal electrode apparatus and method
US7613515B2 (en) 2003-02-03 2009-11-03 Enteromedics Inc. High frequency vagal blockage therapy
US8118722B2 (en) 2003-03-07 2012-02-21 Neuronetics, Inc. Reducing discomfort caused by electrical stimulation
US7783358B2 (en) 2003-03-14 2010-08-24 Endovx, Inc. Methods and apparatus for treatment of obesity with an ultrasound device movable in two or three axes
US7155279B2 (en) 2003-03-28 2006-12-26 Advanced Bionics Corporation Treatment of movement disorders with drug therapy
US7319899B2 (en) 2003-04-23 2008-01-15 Medtronic, Inc. Sensing techniques for implantable medical devices
US7221979B2 (en) 2003-04-30 2007-05-22 Medtronic, Inc. Methods and apparatus for the regulation of hormone release
WO2005007223A2 (en) 2003-07-16 2005-01-27 Sasha John Programmable medical drug delivery systems and methods for delivery of multiple fluids and concentrations
US7616988B2 (en) 2003-09-18 2009-11-10 Cardiac Pacemakers, Inc. System and method for detecting an involuntary muscle movement disorder
US8606356B2 (en) 2003-09-18 2013-12-10 Cardiac Pacemakers, Inc. Autonomic arousal detection system and method
US7263405B2 (en) 2003-08-27 2007-08-28 Neuro And Cardiac Technologies Llc System and method for providing electrical pulses to the vagus nerve(s) to provide therapy for obesity, eating disorders, neurological and neuropsychiatric disorders with a stimulator, comprising bi-directional communication and network capabilities
US20050070974A1 (en) 2003-09-29 2005-03-31 Knudson Mark B. Obesity and eating disorder stimulation treatment with neural block
US20050075702A1 (en) 2003-10-01 2005-04-07 Medtronic, Inc. Device and method for inhibiting release of pro-inflammatory mediator
US7418292B2 (en) 2003-10-01 2008-08-26 Medtronic, Inc. Device and method for attenuating an immune response
US7286880B2 (en) 2003-10-02 2007-10-23 Medtronic, Inc. System and method for transcutaneous energy transfer achieving high efficiency
US7206632B2 (en) 2003-10-02 2007-04-17 Medtronic, Inc. Patient sensory response evaluation for neuromodulation efficacy rating
US20060036209A1 (en) 2003-11-13 2006-02-16 Janardhanan Subramony System and method for transdermal delivery
WO2005051479A2 (en) 2003-11-20 2005-06-09 Advanced Neuromodulation Systems, Inc. Electrical stimulation system and method for treating tinnitus
US7366572B2 (en) 2004-03-16 2008-04-29 Medtronic, Inc. Controlling therapy based on sleep quality
US7395113B2 (en) 2004-03-16 2008-07-01 Medtronic, Inc. Collecting activity information to evaluate therapy
US8690865B2 (en) 2004-05-28 2014-04-08 Georgia Tech Research Corporation Methods and devices for thermal treatment
WO2005122740A2 (en) 2004-06-15 2005-12-29 Compex Technologies, Inc. Interferential and neuromuscular electrical stimulation system and apparatus
US20060004417A1 (en) 2004-06-30 2006-01-05 Cvrx, Inc. Baroreflex activation for arrhythmia treatment
WO2006017634A2 (en) * 2004-08-04 2006-02-16 Ndi Medical, Llc Devices, systems, and methods employing a molded nerve cuff electrode
US20060052856A1 (en) 2004-09-08 2006-03-09 Kim Daniel H Stimulation components
JP2008520280A (en) 2004-11-15 2008-06-19 デチャームス,クリストファー Application of nerve tissue stimulation using light
US7542804B2 (en) 2004-12-03 2009-06-02 Alfred E. Mann Foundation For Scientific Research Neuromuscular stimulation to avoid pulmonary embolisms
US7155281B1 (en) 2004-12-03 2006-12-26 Pacesetter, Inc. Complimentary activity sensor network for disease monitoring and therapy modulation in an implantable device
US9089691B2 (en) 2004-12-07 2015-07-28 Cardiac Pacemakers, Inc. Stimulator for auricular branch of vagus nerve
US20060173493A1 (en) 2005-01-28 2006-08-03 Cyberonics, Inc. Multi-phasic signal for stimulation by an implantable device
US7310557B2 (en) 2005-04-29 2007-12-18 Maschino Steven E Identification of electrodes for nerve stimulation in the treatment of eating disorders
US7899540B2 (en) 2005-04-29 2011-03-01 Cyberonics, Inc. Noninvasively adjustable gastric band
US7389147B2 (en) 2005-04-29 2008-06-17 Medtronic, Inc. Therapy delivery mode selection
US20060282134A1 (en) 2005-06-10 2006-12-14 Shapiro Ronald S Photo-thermal therapeutic device
US20060293721A1 (en) 2005-06-28 2006-12-28 Cyberonics, Inc. Vagus nerve stimulation for treatment of depression with therapeutically beneficial parameter settings
US20070027497A1 (en) 2005-07-27 2007-02-01 Cyberonics, Inc. Nerve stimulation for treatment of syncope
US8660647B2 (en) 2005-07-28 2014-02-25 Cyberonics, Inc. Stimulating cranial nerve to treat pulmonary disorder
US20070027484A1 (en) 2005-07-28 2007-02-01 Cyberonics, Inc. Autonomic nerve stimulation to treat a pancreatic disorder
US7672727B2 (en) * 2005-08-17 2010-03-02 Enteromedics Inc. Neural electrode treatment
US7736382B2 (en) 2005-09-09 2010-06-15 Lockheed Martin Corporation Apparatus for optical stimulation of nerves and other animal tissue
US7988688B2 (en) 2006-09-21 2011-08-02 Lockheed Martin Corporation Miniature apparatus and method for optical stimulation of nerves and other animal tissue
US7620455B2 (en) 2005-10-25 2009-11-17 Cyberonics, Inc. Cranial nerve stimulation to treat eating disorders
US7853322B2 (en) 2005-12-02 2010-12-14 Medtronic, Inc. Closed-loop therapy adjustment
US7957809B2 (en) 2005-12-02 2011-06-07 Medtronic, Inc. Closed-loop therapy adjustment
US8725243B2 (en) 2005-12-28 2014-05-13 Cyberonics, Inc. Methods and systems for recommending an appropriate pharmacological treatment to a patient for managing epilepsy and other neurological disorders
WO2007081732A2 (en) 2006-01-04 2007-07-19 Gordon, Linda, Susan Electronic disease management system
US7801601B2 (en) 2006-01-27 2010-09-21 Cyberonics, Inc. Controlling neuromodulation using stimulus modalities
US20070191906A1 (en) 2006-02-13 2007-08-16 Anand Iyer Method and apparatus for selective nerve stimulation
US20070197984A1 (en) 2006-02-17 2007-08-23 Richardson William C Fecal disposal device
US20070225781A1 (en) 2006-03-21 2007-09-27 Nidus Medical, Llc Apparatus and methods for altering temperature in a region within the body
US7962220B2 (en) 2006-04-28 2011-06-14 Cyberonics, Inc. Compensation reduction in tissue stimulation therapy
US8532787B2 (en) 2007-05-31 2013-09-10 Enteromedics Inc. Implantable therapy system having multiple operating modes
US8170659B2 (en) 2007-12-05 2012-05-01 The Invention Science Fund I, Llc Method for thermal modulation of neural activity
US8165668B2 (en) 2007-12-05 2012-04-24 The Invention Science Fund I, Llc Method for magnetic modulation of neural conduction

Also Published As

Publication number Publication date
US20090149693A1 (en) 2009-06-11
US8165668B2 (en) 2012-04-24
GB2471200A (en) 2010-12-22
GB2471200B (en) 2012-12-05
GB201010161D0 (en) 2010-07-21
GB2467881A (en) 2010-08-18
GB201010162D0 (en) 2010-07-21
WO2009073223A1 (en) 2009-06-11
WO2009075783A1 (en) 2009-06-18
GB2467881B (en) 2012-12-05

Similar Documents

Publication Publication Date Title
WO2009075783A8 (en) System for electrical modulation of neural conduction
GB2467882A (en) System for thermal modulation of neural activity
GB2468441A (en) Method and system for cyclical neural modulation based on activity state
EP3589193A4 (en) Methods and systems for modulating stimuli to the brain with biosensors
WO2012091832A3 (en) Modulation of dynein in skin
EP2160220A4 (en) Microdevice-based electrode assemblies and associated neural stimulation systems, devices, and methods
NZ629697A (en) Human anti-cd27 antibodies, methods and uses
EP1890762B8 (en) Transcranial magnetic stimulation system
EP2914186A4 (en) Systems and methods for creating curved paths through bone and modulating nerves within the bone
EP2304616A4 (en) Methods and systems for single sign on with dynamic authentication levels
EP2651352A4 (en) Systems, devices and methods for bilateral caloric vestibular stimulation
SG10201811584RA (en) Secondary Structure Stabilized NMDA Receptor Modulators And Uses Thereof
EP2178187A4 (en) Power source system, vehicle having the system, and control method for the power source system
TW200716624A (en) Compounds for modulating TRPV3 function
WO2010006072A3 (en) Mtor modulators and uses thereof
MX2011011942A (en) Methods for the diagnosis of oncological disorders using epimetabolic shifters, multidimensional intracellular molecules, or environmental influencers.
PL2062225T3 (en) Method and system for displaying the electric field generated on the brain by transcranial magnetic stimulation
BRPI0618863A2 (en) methods of modulating the activity of a dependent ion channel and treating pain, a disorder associated with the genitourinary or gastrointestinal systems in an individual, and
IL182403A0 (en) Systems and methods for ex-vivo organ care
BR112015005758A2 (en) Methods to Modulate Corticosterone Levels in Psychologically Stressed Individuals
WO2007056124A3 (en) Compounds for modulating trpv3 function
GB2432240B (en) Power consumption control methods applied to communication systems, and related devices
WO2011130227A3 (en) Battery temperature control
WO2010088450A3 (en) Arylamide derivatives useful in the treatment of diseases associated with serca activity
WO2008086483A3 (en) Modulation of neurogenesis with use of modafinil

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 08859606

Country of ref document: EP

Kind code of ref document: A1

NENP Non-entry into the national phase

Ref country code: DE

ENP Entry into the national phase

Ref document number: 1010162

Country of ref document: GB

Kind code of ref document: A

Free format text: PCT FILING DATE = 20081204

WWE Wipo information: entry into national phase

Ref document number: 1010162.4

Country of ref document: GB

122 Ep: pct application non-entry in european phase

Ref document number: 08859606

Country of ref document: EP

Kind code of ref document: A1