WO2008079363A3 - Substituted tetracycline compounds for treatment of inflammatory skin disorders - Google Patents

Substituted tetracycline compounds for treatment of inflammatory skin disorders Download PDF

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Publication number
WO2008079363A3
WO2008079363A3 PCT/US2007/026220 US2007026220W WO2008079363A3 WO 2008079363 A3 WO2008079363 A3 WO 2008079363A3 US 2007026220 W US2007026220 W US 2007026220W WO 2008079363 A3 WO2008079363 A3 WO 2008079363A3
Authority
WO
WIPO (PCT)
Prior art keywords
treatment
skin disorders
inflammatory skin
tetracycline compounds
substituted tetracycline
Prior art date
Application number
PCT/US2007/026220
Other languages
French (fr)
Other versions
WO2008079363A2 (en
Inventor
Haregewein Assefa
Beena Bhatia
Michael Draper
Laura Honeyman
Dennis P Molnar
Original Assignee
Paratek Pharm Innc
Oak K Kim
Haregewein Assefa
Beena Bhatia
Michael Draper
Laura Honeyman
Dennis P Molnar
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to LTEP07870927.6T priority Critical patent/LT2120963T/en
Priority to CA2673486A priority patent/CA2673486C/en
Priority to EP07870927.6A priority patent/EP2120963B1/en
Priority to PL07870927T priority patent/PL2120963T3/en
Priority to AU2007338681A priority patent/AU2007338681B2/en
Priority to ES07870927T priority patent/ES2701725T3/en
Application filed by Paratek Pharm Innc, Oak K Kim, Haregewein Assefa, Beena Bhatia, Michael Draper, Laura Honeyman, Dennis P Molnar filed Critical Paratek Pharm Innc
Priority to DK07870927.6T priority patent/DK2120963T3/en
Priority to SI200732084T priority patent/SI2120963T1/en
Priority to EP18193283.1A priority patent/EP3488853A1/en
Publication of WO2008079363A2 publication Critical patent/WO2008079363A2/en
Publication of WO2008079363A3 publication Critical patent/WO2008079363A3/en
Priority to CY181101329T priority patent/CY1121135T1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/48—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a six-membered aromatic ring being part of a condensed ring system of the same carbon skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/65—Tetracyclines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/10—Anti-acne agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/24—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton
    • C07C237/26—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton of a ring being part of a condensed ring system formed by at least four rings, e.g. tetracycline
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/02—Ortho- or ortho- and peri-condensed systems
    • C07C2603/40—Ortho- or ortho- and peri-condensed systems containing four condensed rings
    • C07C2603/42—Ortho- or ortho- and peri-condensed systems containing four condensed rings containing only six-membered rings
    • C07C2603/44—Naphthacenes; Hydrogenated naphthacenes
    • C07C2603/46—1,4,4a,5,5a,6,11,12a- Octahydronaphthacenes, e.g. tetracyclines

Abstract

Methods and compositions for the treatment of skin disorders (e.g., acne, rosacea) are described.
PCT/US2007/026220 2006-12-21 2007-12-21 Substituted tetracycline compounds for treatment of inflammatory skin disorders WO2008079363A2 (en)

Priority Applications (10)

Application Number Priority Date Filing Date Title
CA2673486A CA2673486C (en) 2006-12-21 2007-12-21 Substituted tetracycline compounds for treatment of inflammatory skin disorders
EP07870927.6A EP2120963B1 (en) 2006-12-21 2007-12-21 Substituted tetracycline compounds for treatment of inflammatory skin disorders
PL07870927T PL2120963T3 (en) 2006-12-21 2007-12-21 Substituted tetracycline compounds for treatment of inflammatory skin disorders
AU2007338681A AU2007338681B2 (en) 2006-12-21 2007-12-21 Substituted tetracycline compounds for treatment of inflammatory skin disorders
ES07870927T ES2701725T3 (en) 2006-12-21 2007-12-21 Compounds of substituted tetracycline for the treatment of inflammatory skin disorders
LTEP07870927.6T LT2120963T (en) 2006-12-21 2007-12-21 Substituted tetracycline compounds for treatment of inflammatory skin disorders
DK07870927.6T DK2120963T3 (en) 2006-12-21 2007-12-21 SUBSTITUTED TETRACYCLINE COMPOUNDS FOR TREATMENT OF INFLAMMATORY SKIN DISORDERS
SI200732084T SI2120963T1 (en) 2006-12-21 2007-12-21 Substituted tetracycline compounds for treatment of inflammatory skin disorders
EP18193283.1A EP3488853A1 (en) 2006-12-21 2007-12-21 Substituted tetracycline compounds for treatment of inflammatory skin disorders
CY181101329T CY1121135T1 (en) 2006-12-21 2018-12-11 SUBSTITUTED FOUR-CYCLINES COMPOUNDS FOR THE TREATMENT OF INFLAMMATIVE SKIN DISORDERS

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US87643406P 2006-12-21 2006-12-21
US60/876,434 2006-12-21

Publications (2)

Publication Number Publication Date
WO2008079363A2 WO2008079363A2 (en) 2008-07-03
WO2008079363A3 true WO2008079363A3 (en) 2008-10-02

Family

ID=39432968

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2007/026220 WO2008079363A2 (en) 2006-12-21 2007-12-21 Substituted tetracycline compounds for treatment of inflammatory skin disorders

Country Status (13)

Country Link
US (2) US8513223B2 (en)
EP (2) EP3488853A1 (en)
AU (1) AU2007338681B2 (en)
CA (2) CA2892739A1 (en)
CY (1) CY1121135T1 (en)
DK (1) DK2120963T3 (en)
ES (1) ES2701725T3 (en)
LT (1) LT2120963T (en)
PL (1) PL2120963T3 (en)
PT (1) PT2120963T (en)
SI (1) SI2120963T1 (en)
TR (1) TR201818983T4 (en)
WO (1) WO2008079363A2 (en)

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AU2466099A (en) * 1998-01-23 1999-08-09 Trustees Of Tufts College Pharmaceutically active compounds and methods of use thereof
US20040224927A1 (en) 2000-06-16 2004-11-11 Trustees Of Tufts College 7-N-substituted phenyl tetracycline compounds
US20020132798A1 (en) 2000-06-16 2002-09-19 Nelson Mark L. 7-phenyl-substituted tetracycline compounds
US7094806B2 (en) 2000-07-07 2006-08-22 Trustees Of Tufts College 7, 8 and 9-substituted tetracycline compounds
US8088820B2 (en) * 2001-04-24 2012-01-03 Paratek Pharmaceuticals, Inc. Substituted tetracycline compounds for the treatment of malaria
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CA2585248A1 (en) * 2004-10-25 2006-05-04 Paratek Pharmaceuticals, Inc. Substituted tetracycline compounds
WO2008127722A1 (en) 2007-04-12 2008-10-23 Paratek Pharmaceuticals, Inc. Methods for treating spinal muscular atrophy using tetracycline compounds
RU2010140682A (en) 2008-03-05 2012-04-10 Пэрэтек Фамэсьютикэлс, Инк. (US) METHOD FOR TREATING PATIENTS FROM INFECTION, PHARMACEUTICAL COMPOSITION (OPTIONS) AND MEDICINE
JP2011517697A (en) * 2008-04-14 2011-06-16 パラテック ファーマシューティカルズ インコーポレイテッド Substituted tetracycline compounds
US9255068B2 (en) * 2011-05-12 2016-02-09 Warner Chilcott Company, Llc Crystalline salts of (4S,4AS,5AR,12AS)-4-dimethylamino-3,10,12,12A-tetrahydroxy-7-[methoxy(methyl)amino)-methyl] acid amide and methods of using the same
US9119793B1 (en) 2011-06-28 2015-09-01 Medicis Pharmaceutical Corporation Gastroretentive dosage forms for doxycycline
JP2015517524A (en) * 2012-05-14 2015-06-22 パラテック ファーマシューティカルズ インコーポレイテッド (4S, 4aS, 5aR, 12aS) -4-dimethylamino-3,10,12,12a-tetrahydroxy-7-[(methoxy (methyl) amino) -methyl] -1,11-dioxo-1,4 Method of using 4a, 5,5a, 6,11,12a-octahydro-naphthacene-2-carboxylic acid amide
US10842802B2 (en) 2013-03-15 2020-11-24 Medicis Pharmaceutical Corporation Controlled release pharmaceutical dosage forms
JP6793715B2 (en) 2015-03-23 2020-12-02 バイオファーミクス・インコーポレイテッドＢｉｏＰｈａｒｍＸ， Ｉｎｃ． Tetracycline skin pharmaceutical composition
CA3042514A1 (en) 2016-11-01 2018-05-11 Paratek Pharmaceuticals, Inc. 9-aminomethyl minocycline compounds and use thereof in treating community-acquired bacterial pneumonia (cabp)
AU2018303807B2 (en) * 2017-07-21 2023-08-24 Almirall, Llc Treatment of non-inflammatory lesions
CN110156624B (en) * 2019-05-29 2022-03-08 河北冀衡药业股份有限公司 Method for synthesizing minocycline and derivatives thereof

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