WO2008033533A3 - Composite drug delivery system - Google Patents

Composite drug delivery system Download PDF

Info

Publication number
WO2008033533A3
WO2008033533A3 PCT/US2007/020059 US2007020059W WO2008033533A3 WO 2008033533 A3 WO2008033533 A3 WO 2008033533A3 US 2007020059 W US2007020059 W US 2007020059W WO 2008033533 A3 WO2008033533 A3 WO 2008033533A3
Authority
WO
WIPO (PCT)
Prior art keywords
delivery systems
drug delivery
bioactive agents
composite drug
fibrous
Prior art date
Application number
PCT/US2007/020059
Other languages
French (fr)
Other versions
WO2008033533A2 (en
Inventor
David M Gravett
Shalaby W Shalaby
Dechi Guan
Philip M Toleikis
Larry Murphy
Kenneth Bruce Ii Thurmond
Original Assignee
Angiotech Pharm Inc
David M Gravett
Shalaby W Shalaby
Dechi Guan
Philip M Toleikis
Larry Murphy
Kenneth Bruce Ii Thurmond
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Angiotech Pharm Inc, David M Gravett, Shalaby W Shalaby, Dechi Guan, Philip M Toleikis, Larry Murphy, Kenneth Bruce Ii Thurmond filed Critical Angiotech Pharm Inc
Publication of WO2008033533A2 publication Critical patent/WO2008033533A2/en
Publication of WO2008033533A3 publication Critical patent/WO2008033533A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L31/16—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/08—Materials for coatings
    • A61L31/10—Macromolecular materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
    • A61L2300/602—Type of release, e.g. controlled, sustained, slow

Abstract

A present invention provides composite drug delivery systems and methods for maintaining or improving a integrity of body passageways (i.e., for example, blood vessels) following surgery, such as at a graft site, or injury. Delivery systems including one or more bioactive agents and a polymer matrix, reinforced by a fibrous construct are described. The fibrous constructs provide a predictable rate of degradation and therapeutic agent release based upon surface area and density relationships. Representative examples of bioactive agents include microtubule stabilizing agents (i.e., for example, paclitaxel), anti-angiogenic factors, inhibitors of smooth muscle cell growth or proliferation, non-steroidal anti-inflammatory drugs, and some factors useful preventing and/or reducing a proliferative biological response that may obstruct or hinder a optimal functioning of a passageway or cavity.
PCT/US2007/020059 2006-09-15 2007-09-14 Composite drug delivery system WO2008033533A2 (en)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US84481406P 2006-09-15 2006-09-15
US60/844,814 2006-09-15
US86075806P 2006-11-22 2006-11-22
US60/860,758 2006-11-22
US90310607P 2007-02-23 2007-02-23
US60/903,106 2007-02-23

Publications (2)

Publication Number Publication Date
WO2008033533A2 WO2008033533A2 (en) 2008-03-20
WO2008033533A3 true WO2008033533A3 (en) 2009-05-22

Family

ID=39032190

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2007/020059 WO2008033533A2 (en) 2006-09-15 2007-09-14 Composite drug delivery system

Country Status (1)

Country Link
WO (1) WO2008033533A2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8986341B2 (en) 2007-12-18 2015-03-24 Intersect Ent, Inc. Self-expanding devices and methods therefor

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2006520786A (en) 2003-03-14 2006-09-14 シネクサス， インコーポレイテッド Sinus delivery of sustained-release therapeutic agents
WO2006107957A2 (en) 2005-04-04 2006-10-12 Sinexus, Inc. Device and methods for treating paranasal sinus conditions
US8535707B2 (en) 2006-07-10 2013-09-17 Intersect Ent, Inc. Devices and methods for delivering active agents to the osteomeatal complex
EP2320832A4 (en) 2008-08-01 2015-07-29 Intersect Ent Inc Methods and devices for crimping self-expanding devices
AU2010248992B2 (en) 2009-05-15 2014-11-27 Intersect Ent, Inc. Expandable devices and methods therefor
EP3636227A1 (en) 2013-03-14 2020-04-15 Intersect ENT, Inc. Systems and devices for treating a sinus condition

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0331345A2 (en) * 1988-03-02 1989-09-06 Pfizer Hospital Products Group, Inc. Triaxially woven fabric for heart valve
WO1996034634A1 (en) * 1995-05-01 1996-11-07 Sam Yang Co. Ltd. Implantable bioresorbable membrane and method for the preparation thereof
WO2001010421A1 (en) * 1999-08-06 2001-02-15 Board Of Regents, The University Of Texas System Drug releasing biodegradable fiber implant
WO2001023014A1 (en) * 1999-09-28 2001-04-05 Depuy International Limited Bone tissue repair kit
US20030004564A1 (en) * 2001-04-20 2003-01-02 Elkins Christopher J. Drug delivery platform
WO2005007209A1 (en) * 2003-07-17 2005-01-27 Bioretec Oy Synthetic, bioabsorbable polymer materials and implants
WO2006083991A2 (en) * 2005-02-04 2006-08-10 Poly-Med, Inc. Fiber-reinforced composite absorbable endoureteral stent

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0331345A2 (en) * 1988-03-02 1989-09-06 Pfizer Hospital Products Group, Inc. Triaxially woven fabric for heart valve
WO1996034634A1 (en) * 1995-05-01 1996-11-07 Sam Yang Co. Ltd. Implantable bioresorbable membrane and method for the preparation thereof
WO2001010421A1 (en) * 1999-08-06 2001-02-15 Board Of Regents, The University Of Texas System Drug releasing biodegradable fiber implant
WO2001023014A1 (en) * 1999-09-28 2001-04-05 Depuy International Limited Bone tissue repair kit
US20030004564A1 (en) * 2001-04-20 2003-01-02 Elkins Christopher J. Drug delivery platform
WO2005007209A1 (en) * 2003-07-17 2005-01-27 Bioretec Oy Synthetic, bioabsorbable polymer materials and implants
WO2006083991A2 (en) * 2005-02-04 2006-08-10 Poly-Med, Inc. Fiber-reinforced composite absorbable endoureteral stent

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8986341B2 (en) 2007-12-18 2015-03-24 Intersect Ent, Inc. Self-expanding devices and methods therefor

Also Published As

Publication number Publication date
WO2008033533A2 (en) 2008-03-20

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