WO2007096623A3 - Implant coating - Google Patents

Implant coating Download PDF

Info

Publication number
WO2007096623A3
WO2007096623A3 PCT/GB2007/000614 GB2007000614W WO2007096623A3 WO 2007096623 A3 WO2007096623 A3 WO 2007096623A3 GB 2007000614 W GB2007000614 W GB 2007000614W WO 2007096623 A3 WO2007096623 A3 WO 2007096623A3
Authority
WO
WIPO (PCT)
Prior art keywords
matrix
carbonyl monomer
vinyl carbonyl
pharmaceutical composition
linking agent
Prior art date
Application number
PCT/GB2007/000614
Other languages
French (fr)
Other versions
WO2007096623A2 (en
Inventor
Diane Baker
Rick Kowalski
Marie-Pierre Voss
Original Assignee
Depuy Int Ltd
Diane Baker
Rick Kowalski
Marie-Pierre Voss
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Depuy Int Ltd, Diane Baker, Rick Kowalski, Marie-Pierre Voss filed Critical Depuy Int Ltd
Publication of WO2007096623A2 publication Critical patent/WO2007096623A2/en
Publication of WO2007096623A3 publication Critical patent/WO2007096623A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/54—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/28—Materials for coating prostheses
    • A61L27/34—Macromolecular materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
    • A61L2300/606—Coatings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2420/00—Materials or methods for coatings medical devices
    • A61L2420/04—Coatings containing a composite material such as inorganic/organic, i.e. material comprising different phases

Abstract

A coating for application to an orthopaedic implant to deliver a pharmaceutical composition. The coating comprises a polymeric matrix which acts as a carrier for the pharmaceutical composition. The matrix is formed from a polymer of at least one hydrophilic substituted or unsubstituted vinyl carbonyl monomer and at least one linking agent which has first and second reactive groups which can react with the vinyl carbonyl monomer so as to link them, spaced by from 3 to 30 repeating units whose chain length is from 2 to 10 atoms. The vinyl carbonyl monomer is present in an amount of from 20% to 90% by volume of the combined volume of the vinyl carbonyl monomer and the linking agent. The matrix also includes a particulate filler which is present in an amount of at least 3% by weight of the total weight of the matrix.
PCT/GB2007/000614 2006-02-24 2007-02-22 Implant coating WO2007096623A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0603704.8A GB0603704D0 (en) 2006-02-24 2006-02-24 Implant coating
GB0603704.8 2006-02-24

Publications (2)

Publication Number Publication Date
WO2007096623A2 WO2007096623A2 (en) 2007-08-30
WO2007096623A3 true WO2007096623A3 (en) 2007-11-29

Family

ID=36178677

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2007/000614 WO2007096623A2 (en) 2006-02-24 2007-02-22 Implant coating

Country Status (2)

Country Link
GB (1) GB0603704D0 (en)
WO (1) WO2007096623A2 (en)

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5626863A (en) * 1992-02-28 1997-05-06 Board Of Regents, The University Of Texas System Photopolymerizable biodegradable hydrogels as tissue contacting materials and controlled-release carriers
US5876743A (en) * 1995-03-21 1999-03-02 Den-Mat Corporation Biocompatible adhesion in tissue repair
WO2000056283A1 (en) * 1999-03-24 2000-09-28 The B.F.Goodrich Company Inhibition of matrix metalloproteinases with polymers and pharmaceutical applications thereof
EP1104681A1 (en) * 1999-12-03 2001-06-06 Biomat B.V. Wire, tube or catheter with hydrophilic coating
US6306422B1 (en) * 1994-02-01 2001-10-23 Caphco, Inc. Compositions and devices for controlled release of active ingredients
WO2004006885A2 (en) * 2002-07-10 2004-01-22 Mnemoscience Gmbh Systems for releasing active ingredients, based on biodegradable or biocompatible polymers with a shape memory effect

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5626863A (en) * 1992-02-28 1997-05-06 Board Of Regents, The University Of Texas System Photopolymerizable biodegradable hydrogels as tissue contacting materials and controlled-release carriers
US6306422B1 (en) * 1994-02-01 2001-10-23 Caphco, Inc. Compositions and devices for controlled release of active ingredients
US5876743A (en) * 1995-03-21 1999-03-02 Den-Mat Corporation Biocompatible adhesion in tissue repair
WO2000056283A1 (en) * 1999-03-24 2000-09-28 The B.F.Goodrich Company Inhibition of matrix metalloproteinases with polymers and pharmaceutical applications thereof
EP1104681A1 (en) * 1999-12-03 2001-06-06 Biomat B.V. Wire, tube or catheter with hydrophilic coating
WO2004006885A2 (en) * 2002-07-10 2004-01-22 Mnemoscience Gmbh Systems for releasing active ingredients, based on biodegradable or biocompatible polymers with a shape memory effect

Also Published As

Publication number Publication date
WO2007096623A2 (en) 2007-08-30
GB0603704D0 (en) 2006-04-05

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