WO2007084549A3 - Drug-eluting stent with atherosclerotic plaques dissolving pharmacological preparation - Google Patents

Drug-eluting stent with atherosclerotic plaques dissolving pharmacological preparation Download PDF

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Publication number
WO2007084549A3
WO2007084549A3 PCT/US2007/001214 US2007001214W WO2007084549A3 WO 2007084549 A3 WO2007084549 A3 WO 2007084549A3 US 2007001214 W US2007001214 W US 2007001214W WO 2007084549 A3 WO2007084549 A3 WO 2007084549A3
Authority
WO
WIPO (PCT)
Prior art keywords
plaque
detergent
angioplasty procedure
eluting stent
dissolving
Prior art date
Application number
PCT/US2007/001214
Other languages
French (fr)
Other versions
WO2007084549A2 (en
Inventor
Filiberto Zadini
Giorgio Zadini
Original Assignee
Filiberto Zadini
Giorgio Zadini
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Filiberto Zadini, Giorgio Zadini filed Critical Filiberto Zadini
Publication of WO2007084549A2 publication Critical patent/WO2007084549A2/en
Publication of WO2007084549A3 publication Critical patent/WO2007084549A3/en
Priority to US12/024,908 priority Critical patent/US8304383B2/en
Priority to US12/211,754 priority patent/US20090035348A1/en
Priority to US13/633,704 priority patent/US8697633B2/en
Priority to US13/871,904 priority patent/US20140234398A1/en
Priority to US14/164,648 priority patent/US20140142071A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/82—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L31/16—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2250/00—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2250/0058—Additional features; Implant or prostheses properties not otherwise provided for
    • A61F2250/0067—Means for introducing or releasing pharmaceutical products into the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/422—Anti-atherosclerotic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/80—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special chemical form
    • A61L2300/802—Additives, excipients, e.g. cyclodextrins, fatty acids, surfactants

Abstract

A drug eluting stent for release over time of a detergent in loco at the site of an angioplasty procedure for the dissolution of the fatty component of the atherosclerotic plaque. The detergent has the capability of passing thru the fibrous cap and of targeting the fatty components of the plaque. The detergent is aimed at dissolving the cholesterol aggregates of the plaque post angioplasty procedure, plaque which is fractured, compressed, locally redistributed by the angioplasty procedure but that it is still present within the artery wall post angioplasty procedure. Numerous other pharmacological compounds with different targeted functions can be combined with the detergent in the stent including Antineoplastics, Immnunosuppressants, Migration inhibitors, Enhanced Healing Factors, Collagen and Proteoglycan degrading enzymes. The drug eluting stent by providing the dissolution of one of the major plaque components i.e. the fatty component is expected to greatly reduce the chance of restenosis.
PCT/US2007/001214 2005-11-22 2007-01-16 Drug-eluting stent with atherosclerotic plaques dissolving pharmacological preparation WO2007084549A2 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
US12/024,908 US8304383B2 (en) 2005-11-22 2008-02-01 Dissolution of arterial plaque
US12/211,754 US20090035348A1 (en) 2005-11-22 2008-09-16 Dissolution of arterial plaque
US13/633,704 US8697633B2 (en) 2005-11-22 2012-10-02 Dissolution of arterial plaque
US13/871,904 US20140234398A1 (en) 2005-11-22 2013-04-26 Dissolution of Arterial Plaque
US14/164,648 US20140142071A1 (en) 2005-11-22 2014-01-27 Regression of arterial plaque

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US76047106P 2006-01-20 2006-01-20
US60/760,471 2006-01-20

Related Child Applications (3)

Application Number Title Priority Date Filing Date
PCT/US2006/044619 Continuation-In-Part WO2007061820A2 (en) 2005-11-22 2006-11-16 Dissolution of arterial cholesterol plaques by a class of pharmacological compounds
US12/024,908 Continuation-In-Part US8304383B2 (en) 2005-11-22 2008-02-01 Dissolution of arterial plaque
US12/211,754 Continuation-In-Part US20090035348A1 (en) 2005-11-22 2008-09-16 Dissolution of arterial plaque

Publications (2)

Publication Number Publication Date
WO2007084549A2 WO2007084549A2 (en) 2007-07-26
WO2007084549A3 true WO2007084549A3 (en) 2007-12-21

Family

ID=38288202

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2007/001214 WO2007084549A2 (en) 2005-11-22 2007-01-16 Drug-eluting stent with atherosclerotic plaques dissolving pharmacological preparation

Country Status (1)

Country Link
WO (1) WO2007084549A2 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102727949A (en) * 2011-10-25 2012-10-17 上海交通大学附属第一人民医院 Drug eluting stone-dissolving bile duct stent and preparation method thereof
CN102727943A (en) * 2011-11-14 2012-10-17 上海市第一人民医院 Biodegradable polymer braided stone-dissolving bile duct stent and preparation method thereof
WO2016100789A1 (en) * 2014-12-19 2016-06-23 Boston Scientific Scimed, Inc. Stent with anti-migration features

Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020091111A1 (en) * 1998-04-08 2002-07-11 Galmed International Limited Bile salt conjugates
US20040143322A1 (en) * 2002-11-08 2004-07-22 Conor Medsystems, Inc. Method and apparatus for treating vulnerable artherosclerotic plaque
US6780849B2 (en) * 2000-12-21 2004-08-24 Scimed Life Systems, Inc. Lipid-based nitric oxide donors
US20040267354A1 (en) * 1994-05-13 2004-12-30 Ringeisen Timothy A. Method for making a porous polymeric material
US20050070997A1 (en) * 2003-09-29 2005-03-31 Ronan Thornton Laminated drug-polymer coated stent with dipped and cured layers
US20050163821A1 (en) * 2002-08-02 2005-07-28 Hsing-Wen Sung Drug-eluting Biodegradable Stent and Delivery Means
US20050177225A1 (en) * 2003-11-10 2005-08-11 Angiotech International Ag Medical implants and anti-scarring agents
US20050249770A1 (en) * 1996-12-02 2005-11-10 Angiotech International Ag Compositions and methods for treating or preventing inflammatory diseases
US20050267407A1 (en) * 2002-02-01 2005-12-01 Vascular Designs, Inc. Multi-function catheter and use thereof

Patent Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040267354A1 (en) * 1994-05-13 2004-12-30 Ringeisen Timothy A. Method for making a porous polymeric material
US20050249770A1 (en) * 1996-12-02 2005-11-10 Angiotech International Ag Compositions and methods for treating or preventing inflammatory diseases
US20020091111A1 (en) * 1998-04-08 2002-07-11 Galmed International Limited Bile salt conjugates
US6780849B2 (en) * 2000-12-21 2004-08-24 Scimed Life Systems, Inc. Lipid-based nitric oxide donors
US20050267407A1 (en) * 2002-02-01 2005-12-01 Vascular Designs, Inc. Multi-function catheter and use thereof
US20050163821A1 (en) * 2002-08-02 2005-07-28 Hsing-Wen Sung Drug-eluting Biodegradable Stent and Delivery Means
US20040143322A1 (en) * 2002-11-08 2004-07-22 Conor Medsystems, Inc. Method and apparatus for treating vulnerable artherosclerotic plaque
US20050070997A1 (en) * 2003-09-29 2005-03-31 Ronan Thornton Laminated drug-polymer coated stent with dipped and cured layers
US20050177225A1 (en) * 2003-11-10 2005-08-11 Angiotech International Ag Medical implants and anti-scarring agents

Also Published As

Publication number Publication date
WO2007084549A2 (en) 2007-07-26

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