WO2007073548A3 - Embolic coils coated with alginate and polyvinylalcohol - Google Patents

Embolic coils coated with alginate and polyvinylalcohol Download PDF

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Publication number
WO2007073548A3
WO2007073548A3 PCT/US2006/062241 US2006062241W WO2007073548A3 WO 2007073548 A3 WO2007073548 A3 WO 2007073548A3 US 2006062241 W US2006062241 W US 2006062241W WO 2007073548 A3 WO2007073548 A3 WO 2007073548A3
Authority
WO
WIPO (PCT)
Prior art keywords
polyvinylalcohol
alginate
embolic coils
coils coated
coated
Prior art date
Application number
PCT/US2006/062241
Other languages
French (fr)
Other versions
WO2007073548A2 (en
Inventor
Marcia S Buiser
Elaine Lee
Original Assignee
Boston Scient Scimed Inc
Marcia S Buiser
Elaine Lee
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US11/430,602 external-priority patent/US8152839B2/en
Priority claimed from US11/458,156 external-priority patent/US20070142859A1/en
Application filed by Boston Scient Scimed Inc, Marcia S Buiser, Elaine Lee filed Critical Boston Scient Scimed Inc
Publication of WO2007073548A2 publication Critical patent/WO2007073548A2/en
Publication of WO2007073548A3 publication Critical patent/WO2007073548A3/en

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/08Materials for coatings
    • A61L31/10Macromolecular materials
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/12Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
    • A61B17/12022Occluding by internal devices, e.g. balloons or releasable wires
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/12Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
    • A61B17/12022Occluding by internal devices, e.g. balloons or releasable wires
    • A61B17/12099Occluding by internal devices, e.g. balloons or releasable wires characterised by the location of the occluder
    • A61B17/12109Occluding by internal devices, e.g. balloons or releasable wires characterised by the location of the occluder in a blood vessel
    • A61B17/12113Occluding by internal devices, e.g. balloons or releasable wires characterised by the location of the occluder in a blood vessel within an aneurysm
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/12Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
    • A61B17/12022Occluding by internal devices, e.g. balloons or releasable wires
    • A61B17/12131Occluding by internal devices, e.g. balloons or releasable wires characterised by the type of occluding device
    • A61B17/1214Coils or wires
    • A61B17/12145Coils or wires having a pre-set deployed three-dimensional shape
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/12Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
    • A61B17/12022Occluding by internal devices, e.g. balloons or releasable wires
    • A61B17/12131Occluding by internal devices, e.g. balloons or releasable wires characterised by the type of occluding device
    • A61B17/1214Coils or wires
    • A61B17/1215Coils or wires comprising additional materials, e.g. thrombogenic, having filaments, having fibers, being coated
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L31/16Biologically active materials, e.g. therapeutic substances
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B05SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05DPROCESSES FOR APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05D7/00Processes, other than flocking, specially adapted for applying liquids or other fluent materials to particular surfaces or for applying particular liquids or other fluent materials
    • B05D7/20Processes, other than flocking, specially adapted for applying liquids or other fluent materials to particular surfaces or for applying particular liquids or other fluent materials to wires
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods, e.g. tourniquets
    • A61B2017/00526Methods of manufacturing
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods, e.g. tourniquets
    • A61B2017/00831Material properties
    • A61B2017/00867Material properties shape memory effect
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods, e.g. tourniquets
    • A61B2017/00831Material properties
    • A61B2017/00898Material properties expandable upon contact with fluid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/12Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
    • A61B17/12022Occluding by internal devices, e.g. balloons or releasable wires
    • A61B2017/1205Introduction devices
    • A61B2017/12054Details concerning the detachment of the occluding device from the introduction device
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/12Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
    • A61B17/12022Occluding by internal devices, e.g. balloons or releasable wires
    • A61B2017/1205Introduction devices
    • A61B2017/12054Details concerning the detachment of the occluding device from the introduction device
    • A61B2017/12063Details concerning the detachment of the occluding device from the introduction device electrolytically detachable
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/10Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing inorganic materials
    • A61L2300/114Nitric oxide, i.e. NO
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00Materials or treatment for tissue regeneration
    • A61L2430/36Materials or treatment for tissue regeneration for embolization or occlusion, e.g. vaso-occlusive compositions or devices
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B05SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05DPROCESSES FOR APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05D1/00Processes for applying liquids or other fluent materials
    • B05D1/18Processes for applying liquids or other fluent materials performed by dipping

Abstract

Coils, such as embolic coils, and related methods, devices, and compositions, are disclosed.
PCT/US2006/062241 2005-12-19 2006-12-18 Embolic coils coated with alginate and polyvinylalcohol WO2007073548A2 (en)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US11/311,617 US8101197B2 (en) 2005-12-19 2005-12-19 Forming coils
US11/311,617 2005-12-19
US11/430,602 2006-05-09
US11/430,602 US8152839B2 (en) 2005-12-19 2006-05-09 Embolic coils
US11/458,156 2006-07-18
US11/458,156 US20070142859A1 (en) 2005-12-19 2006-07-18 Embolic coils

Publications (2)

Publication Number Publication Date
WO2007073548A2 WO2007073548A2 (en) 2007-06-28
WO2007073548A3 true WO2007073548A3 (en) 2008-01-17

Family

ID=53441569

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2006/062241 WO2007073548A2 (en) 2005-12-19 2006-12-18 Embolic coils coated with alginate and polyvinylalcohol

Country Status (2)

Country Link
US (1) US8101197B2 (en)
WO (1) WO2007073548A2 (en)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8152839B2 (en) 2005-12-19 2012-04-10 Boston Scientific Scimed, Inc. Embolic coils
US9375217B2 (en) * 2006-07-18 2016-06-28 Boston Scientific Scimed, Inc. Catheterizing body lumens
WO2008014065A1 (en) * 2006-07-27 2008-01-31 Boston Scientific Limited Particles
JP5179089B2 (en) * 2006-07-28 2013-04-10 テルモ株式会社 Medical long body
WO2008021619A2 (en) * 2006-08-16 2008-02-21 Boston Scientific Limited Polymer particles including covalently bonded chemical species
US8414927B2 (en) 2006-11-03 2013-04-09 Boston Scientific Scimed, Inc. Cross-linked polymer particles
WO2008106480A1 (en) * 2007-03-01 2008-09-04 Boston Scientific Scimed, Inc. Microcatheter introducer sheath
DE602008001444D1 (en) * 2007-03-05 2010-07-15 Boston Scient Scimed Inc STORAGE OF EMBOLICATIVE COILS
ATE526888T1 (en) * 2007-03-08 2011-10-15 Boston Scient Ltd SYSTEM FOR DELIVERING A DETACHABLE IMPLANTABLE PRODUCT
US8500773B2 (en) * 2007-08-01 2013-08-06 Boston Scientific Scimed, Inc. Spring detach joint for delivering a detachable implantable device
US9907555B2 (en) * 2007-08-09 2018-03-06 Boston Scientific Scimed, Inc. Guided detachable interlock and method of use
US7901704B2 (en) * 2007-08-21 2011-03-08 Boston Scientific Scimed, Inc. Embolization
WO2009038922A1 (en) * 2007-08-21 2009-03-26 Boston Scientific Limited Forming embolic particles
US20090068279A1 (en) * 2007-09-12 2009-03-12 Boston Scientific Scimed, Inc. Microspheres with surface projections
WO2009035771A1 (en) * 2007-09-12 2009-03-19 Boston Scientific Limited Embolization particles
US20090092676A1 (en) * 2007-10-03 2009-04-09 Boston Scientific Scimed, Inc. Cross-linked polymer particles
US20090092675A1 (en) * 2007-10-05 2009-04-09 Boston Scientific Scimed, Inc. Compositions containing multiple polymers and particles made using the compositions
US20090099592A1 (en) * 2007-10-15 2009-04-16 Boston Scientific Scimed, Inc. Detachable Interlock Systems and Methods of Use
US8876852B2 (en) * 2008-07-01 2014-11-04 Cook Medical Technologies Llc Occluding device for occlusion of a body vessel and method for making the same
US8968230B2 (en) * 2011-08-30 2015-03-03 Cvdevices, Llc Coil occlusion devices and systems and methods of using the same
US20110046657A1 (en) * 2009-08-20 2011-02-24 Boston Scientific Scimed, Inc. Embolic Coil Introducer Catheter Locking Mechanisms
EP2569026A1 (en) 2010-05-14 2013-03-20 Boston Scientific Scimed, Inc. Endoprosthesis
WO2012094251A2 (en) 2011-01-04 2012-07-12 Massachusetts Institute Of Technology Device and method for sampling bodily fluid for medical analytes in ultra low concentrations
WO2013006298A2 (en) * 2011-07-07 2013-01-10 The Regents Of The University Of California A bioactive spiral coil coating
EP2755574A1 (en) * 2011-09-13 2014-07-23 Stryker Corporation Vaso-occlusive device
US9445461B2 (en) * 2011-11-04 2016-09-13 Ntn Corporation Method of producing a high-frequency heat treatment coil
WO2014164496A1 (en) * 2013-03-11 2014-10-09 Ferry Steven J Flat wound detachable embolization coil
US9655999B2 (en) * 2013-03-12 2017-05-23 Carnegie Mellon University Coated vaso-occlusive device for treatment of aneurysms
RU2016138131A (en) 2014-02-27 2018-03-29 Инкьюмедкс, Инк. EMBOLIZING FRAME MICROSPIRALS
US10869673B2 (en) 2015-02-05 2020-12-22 Boston Scientific Scimed, Inc. Embolic coil with kick-in tail
CN107442707B (en) * 2016-11-29 2020-05-01 微创神通医疗科技(上海)有限公司 Spring ring and preparation method thereof
US20190046212A1 (en) * 2017-08-10 2019-02-14 Koninklijke Philips N.V. Real-time monitoring of fluid flow with flow sensing element in an anuerysm and associated devices, systems, and methods
JP2021126228A (en) * 2020-02-12 2021-09-02 株式会社ナノ・グレインズ Coil sheath and medical device
CN113855137A (en) * 2020-06-30 2021-12-31 微创神通医疗科技(上海)有限公司 Medical spring ring and preparation method thereof
CN112220594A (en) * 2020-10-14 2021-01-15 天津大学 Anti-regurgitation biliary tract stent of conical spiral valve
JP2023554595A (en) 2020-11-19 2023-12-28 ボストン サイエンティフィック サイムド,インコーポレイテッド Apparatus, system and method for coated coils

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5614204A (en) * 1995-01-23 1997-03-25 The Regents Of The University Of California Angiographic vascular occlusion agents and a method for hemostatic occlusion
US6117142A (en) * 1998-03-10 2000-09-12 Cordis Corporation Embolic coil hydraulic deployment system with improved syringe injector
US20010031978A1 (en) * 2000-02-03 2001-10-18 Kipke Daryl R. Method for forming an endovascular occlusion
US20020143348A1 (en) * 2001-03-30 2002-10-03 Wallace Michael P. Embolic devices capable of in-situ reinforcement
US20040093014A1 (en) * 1998-11-10 2004-05-13 Hanh Ho Bioactive components for incorporation with vaso-occlusive members
US20050133046A1 (en) * 2003-12-17 2005-06-23 Becker Timothy A. Compositions and methods for improved occlusion of vascular defects
EP1547530A1 (en) * 2003-12-17 2005-06-29 Cordis Neurovascular, Inc. Activatable bioactive vascular occlusive device and method of use
EP1738695A1 (en) * 2005-06-30 2007-01-03 Cordis Development Corporation Method of making a coated embolization device

Family Cites Families (365)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE233303C (en) 1911-04-05
US2609347A (en) 1948-05-27 1952-09-02 Wilson Christopher Lumley Method of making expanded polyvinyl alcohol-formaldehyde reaction product and product resulting therefrom
JPS4820019B1 (en) 1969-06-05 1973-06-18
US3737398A (en) 1969-11-13 1973-06-05 D Yamaguchi Method of making a polyvinyl acetal sponge buff
US3921632A (en) 1974-08-16 1975-11-25 Frank M Bardani Implant device
CS179075B1 (en) 1974-11-26 1977-10-31 Stoy Vladimir Mode of manufacture of spherical particles from polymer
US4076640A (en) 1975-02-24 1978-02-28 Xerox Corporation Preparation of spheroidized particles
US3957933A (en) 1975-03-05 1976-05-18 General Atomic Company Apparatus for producing microspherical particles and method for operating such apparatus
JPS51135958A (en) 1975-05-20 1976-11-25 Fuji Photo Film Co Ltd Method of making fine powder polymer having pores
US4025686A (en) 1975-06-26 1977-05-24 Owens-Corning Fiberglas Corporation Molded composite article and method for making the article
US4034759A (en) 1975-08-27 1977-07-12 Xomed, Inc. Moisture-expandable prosthesis
US4098728A (en) 1976-01-02 1978-07-04 Solomon Rosenblatt Medical surgical sponge and method of making same
US4055377A (en) 1976-08-03 1977-10-25 Minnesota Mining And Manufacturing Company Magnetically orientable retroreflectorization particles
GB1591924A (en) 1976-10-25 1981-07-01 Berger Jenson & Nicholson Ltd Polymer aggregates
US4159719A (en) 1977-05-09 1979-07-03 Xomed, Inc. Moisture-expandable ear wick
US4900303A (en) 1978-03-10 1990-02-13 Lemelson Jerome H Dispensing catheter and method
ES478736A1 (en) 1978-03-23 1979-06-01 Hoechst Ag Polyvinyl alcohol pellets containing a plasticizer, and method for their preparation.
DE2834539A1 (en) 1978-08-07 1980-02-21 Basf Ag MACROPOROUS POLYMERS AS CARRIER MATERIAL FOR THE COVALENT BINDING OF PROTEINS
US4793980A (en) 1978-09-21 1988-12-27 Torobin Leonard B Hollow porous microspheres as substrates and containers for catalyst
US4243794A (en) 1978-10-10 1981-01-06 Minnesota Mining And Manufacturing Company Mixture of rough and spheroidized resin particles
US4198318A (en) 1978-11-24 1980-04-15 Conoco, Inc. Production of high strength alumina spheres by hydrogelling corresponding slurries
US4268495A (en) 1979-01-08 1981-05-19 Ethicon, Inc. Injectable embolization and occlusion solution
US4246208A (en) 1979-03-22 1981-01-20 Xerox Corporation Dust-free plasma spheroidization
US4346712A (en) 1979-04-06 1982-08-31 Kuraray Company, Ltd. Releasable balloon catheter
HU184722B (en) 1980-02-18 1984-10-29 Laszlo Lazar Therapeutically suitable silicone rubber mixture and therapeuticaid
US4271281A (en) 1980-05-29 1981-06-02 American Hoechst Corporation Process for preparing styrenic polymer particles
DE3031737A1 (en) 1980-08-22 1982-04-01 Bayer Ag, 5090 Leverkusen METHOD FOR PRODUCING PEARL POLYMERISATS OF UNIFORM PARTICLE SIZE
CA1166413A (en) 1980-10-30 1984-05-01 Edward E. Timm Process and apparatus for preparing uniform size polymer beads
US4681119A (en) 1980-11-17 1987-07-21 Schering Aktiengesellschaft Method of production and use of microbubble precursors
US4657756A (en) 1980-11-17 1987-04-14 Schering Aktiengesellschaft Microbubble precursors and apparatus for their production and use
US4442843A (en) 1980-11-17 1984-04-17 Schering, Ag Microbubble precursors and methods for their production and use
NZ199916A (en) 1981-03-11 1985-07-12 Unilever Plc Low density polymeric block material for use as carrier for included liquids
US4678814A (en) 1981-03-30 1987-07-07 California Institute Of Technology Polyacrolein microspheres
US4413070A (en) 1981-03-30 1983-11-01 California Institute Of Technology Polyacrolein microspheres
US4622362A (en) 1981-03-30 1986-11-11 California Institute Of Technology Polyacrolein microspheres
CA1177811A (en) 1981-04-13 1984-11-13 Theo G. Spek Process for the preparation of silica particles; silica particles with a narrow pore diameter distribution, catalysts made therefrom and use of these catalysts
US4428869A (en) 1981-08-20 1984-01-31 International Flavors & Fragrances Inc. Cologne consisting of microcapsule suspension
US4456693A (en) 1982-03-08 1984-06-26 W. R. Grace & Co. Hydrocracking catalyst
US4452773A (en) 1982-04-05 1984-06-05 Canadian Patents And Development Limited Magnetic iron-dextran microspheres
US4472552A (en) 1982-09-27 1984-09-18 W. R. Grace & Co. Continuous process for making solid, free-flowing water dispersible PVA-aldehyde reaction product
US4459145A (en) 1982-09-30 1984-07-10 The United States Of America As Represented By The United States Department Of Energy Fabrication of glass microspheres with conducting surfaces
DE3313947A1 (en) 1983-04-15 1984-10-18 Schering AG, 1000 Berlin und 4709 Bergkamen MICROPARTICLES AND GAS BUBBLES CONTAINING ULTRASONIC CONTRASTING AGENTS
DE3834705A1 (en) 1988-10-07 1990-04-12 Schering Ag ULTRASONIC CONTRASTING AGENTS FROM GAS BUBBLES AND MICROPARTICLES CONTAINING FATTY ACID
DE3313946A1 (en) 1983-04-15 1984-10-18 Schering AG, 1000 Berlin und 4709 Bergkamen MICROPARTICLES AND GAS BUBBLES CONTAINING ULTRASONIC CONTRASTING AGENTS
CA1225585A (en) 1983-06-30 1987-08-18 Maria T. Litvinova Composition for embolization of blood vessels
US4492720A (en) 1983-11-15 1985-01-08 Benjamin Mosier Method of preparing microspheres for intravascular delivery
US4573967A (en) 1983-12-06 1986-03-04 Eli Lilly And Company Vacuum vial infusion system
US4671954A (en) 1983-12-13 1987-06-09 University Of Florida Microspheres for incorporation of therapeutic substances and methods of preparation thereof
US4551436A (en) 1984-04-11 1985-11-05 General Electric Company Fabrication of small dense silicon carbide spheres
US4674480A (en) 1984-05-25 1987-06-23 Lemelson Jerome H Drug compositions and methods of applying same
FR2566384B1 (en) 1984-06-21 1986-09-05 Saint Gobain Vitrage IMPROVEMENTS IN TECHNIQUES FOR THE PRODUCTION OF GLASS MICROSPHERES
DE3527482A1 (en) 1984-07-31 1986-02-06 Fuji Spinning Co., Ltd., Tokio/Tokyo METHOD FOR PRODUCING GRAINY POROUS CHITOSAN
GB8419708D0 (en) 1984-08-02 1984-09-05 Shell Int Research Preparation of silica spheres
US4623706A (en) 1984-08-23 1986-11-18 The Dow Chemical Company Process for preparing uniformly sized polymer particles by suspension polymerization of vibratorily excited monomers in a gaseous or liquid stream
JPS61101242A (en) 1984-10-22 1986-05-20 Showa Denko Kk Production of coated substance
US4789501A (en) 1984-11-19 1988-12-06 The Curators Of The University Of Missouri Glass microspheres
US4675113A (en) 1984-11-28 1987-06-23 University Patents, Inc. Affinity chromatography using dried calcium alginate-magnetite separation media in a magnetically stabilized fluidized bed
DE3568442D1 (en) 1984-12-06 1989-04-06 Kanegafuchi Chemical Ind A method of preparation of droplets
US5106903A (en) 1984-12-17 1992-04-21 Lehigh University Preparation of large particle size monodisperse latexes
US4897255A (en) 1985-01-14 1990-01-30 Neorx Corporation Metal radionuclide labeled proteins for diagnosis and therapy
JPH0678460B2 (en) 1985-05-01 1994-10-05 株式会社バイオマテリアル・ユニバース Porous transparent polyvinyl alcohol gel
JPS61293911A (en) 1985-06-24 1986-12-24 Teisan Seiyaku Kk Sustained release preparation
US4708718A (en) 1985-07-02 1987-11-24 Target Therapeutics Hyperthermic treatment of tumors
SE459005B (en) 1985-07-12 1989-05-29 Aake Rikard Lindahl SET TO MANUFACTURE SPHERICAL POLYMER PARTICLES
USH915H (en) 1985-07-22 1991-05-07 Gibbs Marylu B Controlled macroporous copolymer properties by removal of impurities in the diluent
US4742086A (en) 1985-11-02 1988-05-03 Lion Corporation Process for manufacturing porous polymer
DE3543348A1 (en) 1985-12-07 1987-06-11 Bayer Ag PEARL-SHAPED CROSS-NETWORKED MIXED POLYMERS WITH EPOXY AND BASIC AMINO GROUPS, METHOD FOR THE PRODUCTION THEREOF AND THEIR USE
JPS62169723A (en) 1986-01-22 1987-07-25 Teisan Seiyaku Kk Sustained release preparation
US4929400A (en) 1986-04-28 1990-05-29 California Institute Of Technology Production of monodisperse, polymeric microspheres
US5262176A (en) 1986-07-03 1993-11-16 Advanced Magnetics, Inc. Synthesis of polysaccharide covered superparamagnetic oxide colloids
JPS6317904A (en) 1986-07-09 1988-01-25 Mitsubishi Chem Ind Ltd Production of crosslinked porous polyvinyl alcohol particle
US4743507A (en) 1986-09-12 1988-05-10 Franses Elias I Nonspherical microparticles and method therefor
US5114421A (en) 1986-09-22 1992-05-19 Polak Robert B Medicament container/dispenser assembly
US4859711A (en) 1986-10-01 1989-08-22 Alcan International Limited Hollow microspheres
CA1287459C (en) 1986-10-01 1991-08-13 Mukesh Jain Process for the preparation of hollow microspheres
US5263992A (en) 1986-10-17 1993-11-23 Bio-Metric Systems, Inc. Biocompatible device with covalently bonded biocompatible agent
EP0265924B2 (en) 1986-10-29 1998-04-22 Kanegafuchi Kagaku Kogyo Kabushiki Kaisha Uniform polymer particles
US5292814A (en) 1987-04-29 1994-03-08 Ernst Bayer Process for the preparation of monodispersed polymer beads
US4795741A (en) 1987-05-06 1989-01-03 Biomatrix, Inc. Compositions for therapeutic percutaneous embolization and the use thereof
JPH0612993B2 (en) 1987-08-10 1994-02-23 株式会社クラレ Method for producing spherical microbe-immobilized moldings
US4819637A (en) 1987-09-01 1989-04-11 Interventional Therapeutics Corporation System for artificial vessel embolization and devices for use therewith
JPH0762054B2 (en) 1987-10-13 1995-07-05 倉敷紡績株式会社 Crosslinked polymer particles
US4804366A (en) 1987-10-29 1989-02-14 Baxter International Inc. Cartridge and adapter for introducing a beneficial agent into an intravenous delivery system
US4850978A (en) 1987-10-29 1989-07-25 Baxter International Inc. Drug delivery cartridge with protective cover
US4981625A (en) 1988-03-14 1991-01-01 California Institute Of Technology Monodisperse, polymeric microspheres produced by irradiation of slowly thawing frozen drops
FR2634376B1 (en) 1988-07-21 1992-04-17 Farmalyoc NOVEL SOLID AND POROUS UNIT FORM COMPRISING MICROPARTICLES AND / OR NANOPARTICLES, AS WELL AS ITS PREPARATION
DE68922497T2 (en) 1988-08-24 1995-09-14 Marvin J Slepian ENDOLUMINAL SEAL WITH BISDEGRADABLE POLYMERS.
DE3829938A1 (en) 1988-09-02 1990-03-29 Hermann Hofmann ORGANO-MINERAL DUENGER AND METHOD FOR THE PRODUCTION THEREOF
US4933372A (en) 1988-09-26 1990-06-12 Supelco, Inc. Porous rigid resins and process of preparation
US5047438A (en) 1988-09-26 1991-09-10 Supelco, Inc. Porous rigid resins and process of preparation
US4994069A (en) 1988-11-02 1991-02-19 Target Therapeutics Vaso-occlusion coil and method
US5681576A (en) 1988-11-16 1997-10-28 Mdv Technologies, Inc. Method and composition for post surgical adhesion reduction
DE3841401A1 (en) 1988-12-08 1990-06-13 Martin Lemperle ALLOPLASTIC IMPLANT
US5258028A (en) 1988-12-12 1993-11-02 Ersek Robert A Textured micro implants
US4946899A (en) 1988-12-16 1990-08-07 The University Of Akron Thermoplastic elastomers of isobutylene and process of preparation
GB8900376D0 (en) 1989-01-09 1989-03-08 Nycomed As Iodinated esters
FR2641692A1 (en) 1989-01-17 1990-07-20 Nippon Zeon Co Plug for closing an opening for a medical application, and device for the closure plug making use thereof
US5091205A (en) 1989-01-17 1992-02-25 Union Carbide Chemicals & Plastics Technology Corporation Hydrophilic lubricious coatings
US5032117A (en) 1989-01-30 1991-07-16 Motta Louis J Tandem syringe
FR2644056A1 (en) 1989-03-13 1990-09-14 Fiandrino Alain (Surgical) clamp forceps
GB8905934D0 (en) 1989-03-15 1989-04-26 Dow Europ Sa A process for preparing adsorptive porous resin beads
CA2017570C (en) 1989-05-31 2000-12-19 James R. Gross Porous structure of an absorbent polymer
US5354290A (en) 1989-05-31 1994-10-11 Kimberly-Clark Corporation Porous structure of an absorbent polymer
US5158573A (en) 1989-06-09 1992-10-27 American Medical Systems, Inc. Injectable polymeric bodies
US5007940A (en) 1989-06-09 1991-04-16 American Medical Systems, Inc. Injectable polymeric bodies
US5116387A (en) 1989-06-09 1992-05-26 American Medical Systems, Inc. Preparation of injectable polymeric bodies
US5190760A (en) 1989-07-08 1993-03-02 Coopers Animal Health Limited Solid pharmaceutical composition
US5698271A (en) 1989-08-22 1997-12-16 Immunivest Corporation Methods for the manufacture of magnetically responsive particles
US5253991A (en) 1989-11-20 1993-10-19 Sumitomo Cement Co., Ltd. Apparatus for producing spheroidal inorganic particulate material
US5922304A (en) 1989-12-22 1999-07-13 Imarx Pharmaceutical Corp. Gaseous precursor filled microspheres as magnetic resonance imaging contrast agents
US5580575A (en) 1989-12-22 1996-12-03 Imarx Pharmaceutical Corp. Therapeutic drug delivery systems
US5469854A (en) 1989-12-22 1995-11-28 Imarx Pharmaceutical Corp. Methods of preparing gas-filled liposomes
US5542935A (en) 1989-12-22 1996-08-06 Imarx Pharmaceutical Corp. Therapeutic delivery systems related applications
US5585112A (en) 1989-12-22 1996-12-17 Imarx Pharmaceutical Corp. Method of preparing gas and gaseous precursor-filled microspheres
US6306427B1 (en) 1989-12-28 2001-10-23 Rhone-Poulenc Nutrition Animale Pellets containing active ingredients protected against degradation in the rumen of ruminants
US5435645A (en) 1989-12-29 1995-07-25 Tecres Spa Process and apparatus for the mixing and direct emplacement of a two-component bone cement
US5122136A (en) 1990-03-13 1992-06-16 The Regents Of The University Of California Endovascular electrolytically detachable guidewire tip for the electroformation of thrombus in arteries, veins, aneurysms, vascular malformations and arteriovenous fistulas
US5354295A (en) 1990-03-13 1994-10-11 Target Therapeutics, Inc. In an endovascular electrolytically detachable wire and tip for the formation of thrombus in arteries, veins, aneurysms, vascular malformations and arteriovenous fistulas
US5147937A (en) 1990-03-22 1992-09-15 Rohm And Haas Company Process for making controlled, uniform-sized particles in the 1 to 50 micrometer range
US5556610A (en) 1992-01-24 1996-09-17 Bracco Research S.A. Gas mixtures useful as ultrasound contrast media, contrast agents containing the media and method
JPH03297475A (en) 1990-04-16 1991-12-27 Ken Ishihara Controlling method for emission of medicine by means of resonance sound wave
US5514090A (en) 1990-04-24 1996-05-07 Science Incorporated Closed drug delivery system
US5137928A (en) 1990-04-26 1992-08-11 Hoechst Aktiengesellschaft Ultrasonic contrast agents, processes for their preparation and the use thereof as diagnostic and therapeutic agents
US5021059A (en) 1990-05-07 1991-06-04 Kensey Nash Corporation Plug device with pulley for sealing punctures in tissue and methods of use
CA2016870C (en) 1990-05-15 1994-03-29 Arnie Drudik Dispenser for storing and mixing several components
US5342394A (en) 1990-05-16 1994-08-30 Olympus Optical Co., Ltd. Apparatus for blocking a vein branch and method of blocking a vein branch
AU636481B2 (en) 1990-05-18 1993-04-29 Bracco International B.V. Polymeric gas or air filled microballoons usable as suspensions in liquid carriers for ultrasonic echography
JP2514087Y2 (en) 1990-05-25 1996-10-16 幸三 牧田 Balloon with detachable double-sided check valve
US6291605B1 (en) 1990-06-06 2001-09-18 Clarence S. Freeman Polymerization process with spraying step
US5108407A (en) 1990-06-08 1992-04-28 Rush-Presbyterian St. Luke's Medical Center Method and apparatus for placement of an embolic coil
JP3286315B2 (en) 1990-06-20 2002-05-27 アドバンスト ポリマー システムズ,インコーポレイティド Compositions and methods for controlled release of soluble actives
EP0470569B1 (en) 1990-08-08 1995-11-22 Takeda Chemical Industries, Ltd. Intravascular embolizing agent containing angiogenesis inhibiting substance
US5484584A (en) 1990-10-02 1996-01-16 Board Of Regents, The University Of Texas System Therapeutic and diagnostic use of modified polymeric microcapsules
US5149543A (en) 1990-10-05 1992-09-22 Massachusetts Institute Of Technology Ionically cross-linked polymeric microcapsules
US5167624A (en) 1990-11-09 1992-12-01 Catheter Research, Inc. Embolus delivery system and method
US5120349A (en) 1990-12-07 1992-06-09 Landec Labs, Inc. Microcapsule having temperature-dependent permeability profile
US5171214A (en) 1990-12-26 1992-12-15 Abbott Laboratories Drug storage and delivery system
DE4104702C2 (en) 1991-02-15 1996-01-18 Malte Neuss Implants for organ pathways in spiral form
US5171217A (en) 1991-02-28 1992-12-15 Indiana University Foundation Method for delivery of smooth muscle cell inhibitors
US5147631A (en) 1991-04-30 1992-09-15 Du Pont Merck Pharmaceutical Company Porous inorganic ultrasound contrast agents
FR2676927B1 (en) 1991-05-29 1995-06-23 Ibf MICROSPHERES FOR USE IN THERAPEUTIC VASCULAR OCCLUSIONS AND INJECTABLE SOLUTIONS CONTAINING THEM.
WO1992021382A1 (en) 1991-06-03 1992-12-10 Holmes, Michael, John Improvements in or relating to contrast agents
GB9116610D0 (en) 1991-08-01 1991-09-18 Danbiosyst Uk Preparation of microparticles
US5216096A (en) 1991-09-24 1993-06-01 Japan Synthetic Rubber Co., Ltd. Process for the preparation of cross-linked polymer particles
US5811447A (en) 1993-01-28 1998-09-22 Neorx Corporation Therapeutic inhibitor of vascular smooth muscle cells
CA2079509C (en) 1991-10-01 2002-05-14 Shigeyuki Takada Prolonged release microparticle preparation and production of the same
US5226911A (en) 1991-10-02 1993-07-13 Target Therapeutics Vasoocclusion coil with attached fibrous element(s)
US5256146A (en) 1991-10-11 1993-10-26 W. D. Ensminger Vascular catheterization system with catheter anchoring feature
JP3356447B2 (en) 1991-10-16 2002-12-16 テルモ株式会社 Vascular lesion embolic material composed of dried polymer gel
US5290310A (en) 1991-10-30 1994-03-01 Howmedica, Inc. Hemostatic implant introducer
US5411520A (en) 1991-11-08 1995-05-02 Kensey Nash Corporation Hemostatic vessel puncture closure system utilizing a plug located within the puncture tract spaced from the vessel, and method of use
EP0791333B1 (en) 1991-12-12 1999-12-01 Target Therapeutics, Inc. Detachable pusher-vasoocclusive coil assembly with interlocking coupling
US5234437A (en) 1991-12-12 1993-08-10 Target Therapeutics, Inc. Detachable pusher-vasoocclusion coil assembly with threaded coupling
US5261916A (en) 1991-12-12 1993-11-16 Target Therapeutics Detachable pusher-vasoocclusive coil assembly with interlocking ball and keyway coupling
US5258042A (en) 1991-12-16 1993-11-02 Henry Ford Health System Intravascular hydrogel implant
EP0625070B1 (en) 1991-12-20 1998-07-08 AlliedSignal Inc. Low density materials having high surface areas and articles formed therefrom for use in the recovery of metals
US5260002A (en) 1991-12-23 1993-11-09 Vanderbilt University Method and apparatus for producing uniform polymeric spheres
DE69233638T2 (en) 1991-12-24 2007-07-12 E.I. Du Pont De Nemours And Co., Wilmington TWO STABILIZED MICROPARTICLES
GB9200391D0 (en) 1992-01-09 1992-02-26 Nycomed As Improvements in or relating to contrast agents
GB9200388D0 (en) 1992-01-09 1992-02-26 Nycomed As Improvements in or relating to contrast agents
US6537574B1 (en) 1992-02-11 2003-03-25 Bioform, Inc. Soft tissue augmentation material
US5480644A (en) 1992-02-28 1996-01-02 Jsf Consultants Ltd. Use of injectable biomaterials for the repair and augmentation of the anal sphincters
CN1084410A (en) 1992-03-06 1994-03-30 奈科姆成像有限公司 Relate to the improvement of contrast agent
JP3004724B2 (en) 1992-04-06 2000-01-31 ユーロプラスティ インコーポレイテッド Treatment of reflux obstruction by microparticle injection
EP0565086B1 (en) 1992-04-10 1996-12-27 Mitsubishi Chemical Corporation Method for producing a spherical acrylonitrile crosslinked copolymer
US6235313B1 (en) 1992-04-24 2001-05-22 Brown University Research Foundation Bioadhesive microspheres and their use as drug delivery and imaging systems
US5263964A (en) 1992-05-06 1993-11-23 Coil Partners Ltd. Coaxial traction detachment apparatus and method
AU4198793A (en) 1992-07-24 1994-01-27 Takeda Chemical Industries Ltd. Microparticle preparation and production thereof
US5292332A (en) 1992-07-27 1994-03-08 Lee Benjamin I Methods and device for percutanceous sealing of arterial puncture sites
US5807323A (en) 1992-08-13 1998-09-15 Science Incorporated Mixing and delivery syringe assembly
US6592859B1 (en) 1992-08-20 2003-07-15 Ethicon, Inc. Controlled expansion sphincter augmentation media
US5512604A (en) 1992-08-28 1996-04-30 The Dow Chemical Company Porous copolymers having a cellular polymeric structure suitable for preparing ion-exchange resins and adsorbents
DK0660724T3 (en) 1992-09-16 1998-11-02 Nycomed Imaging As Preparations for contrast agents
AU4926193A (en) 1992-09-21 1994-04-12 Vitaphore Corporation Embolization plugs for blood vessels
US5350397A (en) 1992-11-13 1994-09-27 Target Therapeutics, Inc. Axially detachable embolic coil assembly
US5250071A (en) 1992-09-22 1993-10-05 Target Therapeutics, Inc. Detachable embolic coil assembly using interlocking clasps and method of use
USRE37117E1 (en) 1992-09-22 2001-03-27 Target Therapeutics, Inc. Detachable embolic coil assembly using interlocking clasps and method of use
US5312415A (en) 1992-09-22 1994-05-17 Target Therapeutics, Inc. Assembly for placement of embolic coils using frictional placement
KR960001417B1 (en) 1992-09-26 1996-01-27 한국과학기술원 Method for preparing an improved porous polymer bead
GB9221329D0 (en) 1992-10-10 1992-11-25 Delta Biotechnology Ltd Preparation of further diagnostic agents
US5382260A (en) 1992-10-30 1995-01-17 Interventional Therapeutics Corp. Embolization device and apparatus including an introducer cartridge and method for delivering the same
US5369163A (en) 1992-11-13 1994-11-29 Rohm And Haas Company Process for preparing large dimension emulsion polymer particles, polymer product and uses thereof
US5690666A (en) 1992-11-18 1997-11-25 Target Therapeutics, Inc. Ultrasoft embolism coils and process for using them
US5349957A (en) 1992-12-02 1994-09-27 Sterling Winthrop Inc. Preparation and magnetic properties of very small magnetite-dextran particles
US5334216A (en) 1992-12-10 1994-08-02 Howmedica Inc. Hemostatic plug
JP3256583B2 (en) 1992-12-10 2002-02-12 株式会社リコー Electrophotographic toner and method for producing the same
US5288763A (en) 1992-12-23 1994-02-22 The Johns Hopkins University School Of Medicine Porous, polymer beads and process of their preparation
US6482436B1 (en) 1993-01-29 2002-11-19 Ferx Incorporated Magnetically responsive composition
US5328936A (en) 1993-02-01 1994-07-12 Rohm And Haas Company Polymerization process for making porous polymeric particles
US6090925A (en) 1993-03-09 2000-07-18 Epic Therapeutics, Inc. Macromolecular microparticles and methods of production and use
US5320639A (en) 1993-03-12 1994-06-14 Meadox Medicals, Inc. Vascular plug delivery system
US5925059A (en) 1993-04-19 1999-07-20 Target Therapeutics, Inc. Detachable embolic coil assembly
US5800453A (en) 1993-04-19 1998-09-01 Target Therapeutics, Inc. Detachable embolic coil assembly using interlocking hooks and slots
US5567415A (en) 1993-05-12 1996-10-22 The Board Of Regents Of The University Of Nebraska Ultrasound contrast agents and methods for their manufacture and use
US5701899A (en) 1993-05-12 1997-12-30 The Board Of Regents Of The University Of Nebraska Perfluorobutane ultrasound contrast agent and methods for its manufacture and use
US5695740A (en) 1993-05-12 1997-12-09 The Board Of Regents Of The University Of Nebraska Perfluorocarbon ultrasound contrast agent comprising microbubbles containing a filmogenic protein and a saccharide
US5344867A (en) 1993-06-14 1994-09-06 The Bfgoodrich Company Vinylidene chloride emulsion interpolymer composition
US5994341A (en) 1993-07-19 1999-11-30 Angiogenesis Technologies, Inc. Anti-angiogenic Compositions and methods for the treatment of arthritis
CN100998869A (en) 1993-07-19 2007-07-18 血管技术药物公司 Anti-angiogene compositions and methods of use
US5398851A (en) 1993-08-06 1995-03-21 River Medical, Inc. Liquid delivery device
US5397303A (en) 1993-08-06 1995-03-14 River Medical, Inc. Liquid delivery device having a vial attachment or adapter incorporated therein
US5443495A (en) 1993-09-17 1995-08-22 Scimed Lifesystems Inc. Polymerization angioplasty balloon implant device
US5531716A (en) 1993-09-29 1996-07-02 Hercules Incorporated Medical devices subject to triggered disintegration
US5556391A (en) 1993-10-01 1996-09-17 Merocel Corporation Surgical sponge device
DE1258262T1 (en) 1993-10-28 2003-04-10 Medrad Inc Contrast delivery system
AU679295B2 (en) 1993-12-15 1997-06-26 Bracco Suisse S.A. Gas mixtures useful as ultrasound contrast media
US5885547A (en) 1994-01-21 1999-03-23 Paragon Medical Ltd. Particulate material
US5417982A (en) 1994-02-17 1995-05-23 Modi; Pankaj Controlled release of drugs or hormones in biodegradable polymer microspheres
US5569468A (en) 1994-02-17 1996-10-29 Modi; Pankaj Vaccine delivery system for immunization, using biodegradable polymer microspheres
DE69505949T2 (en) 1994-02-17 1999-06-02 Pankaj Modi MEDICINAL PRODUCTS, VACCINE AND HORMONE IN POLYLACTIDE-COATED MICROPARTICLES
AU705305B2 (en) 1994-03-18 1999-05-20 Cook Medical Technologies Llc Helical embolization coil
US5431174A (en) 1994-04-04 1995-07-11 Via Medical Corporation Method of fluid delivery and collection
WO1995029661A1 (en) 1994-04-28 1995-11-09 Primed Halberstadt Medizintechnik Gmbh One-piece dispensing device for the contamination-free administration of medicaments (cytostatica)
US5534589A (en) 1994-05-04 1996-07-09 Minnesota Mining And Manufacturing Company Repulpable plastic films
WO1995031485A1 (en) 1994-05-15 1995-11-23 Pharmacia Biotech Ab A method of manufacturing particles, and particles that can be produced in accordance with the method
JP2535785B2 (en) 1994-06-03 1996-09-18 工業技術院長 Vascular embolic agent
US5583162A (en) 1994-06-06 1996-12-10 Biopore Corporation Polymeric microbeads and method of preparation
US5639710A (en) 1994-07-06 1997-06-17 Zeneca Limited Solid microspheres for agriculturally active compounds and process for their production
ATE207374T1 (en) 1994-08-17 2001-11-15 Boston Scient Corp IMPLANT AND APPLICATION DEVICE
US5827531A (en) 1994-12-02 1998-10-27 The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration Microcapsules and methods for making
US6099864A (en) 1994-12-02 2000-08-08 The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration In situ activation of microcapsules
IL116561A0 (en) 1994-12-30 1996-03-31 Target Therapeutics Inc Severable joint for detachable devices placed within the body
DK175166B1 (en) 1995-01-03 2004-06-21 Cook William Europ Method of manufacturing an assembly for placing an embolization coil in the vascular system and such assembly as well as an apparatus for advancing the assembly
CA2207667A1 (en) 1995-01-27 1996-08-01 Scimed Life Systems, Inc. Embolizing system
US6179817B1 (en) 1995-02-22 2001-01-30 Boston Scientific Corporation Hybrid coating for medical devices
DE69521025T2 (en) 1995-03-07 2001-10-04 Menlo Care Inc Means to improve sphincter function with controlled expansion
US5569193A (en) 1995-03-22 1996-10-29 Abbott Laboratories Syringe system accommodating separately storable prefilled containers for two constituents
US5785682A (en) 1995-03-22 1998-07-28 Abbott Laboratories Pre-filled syringe drug delivery system
US5637087A (en) 1995-03-22 1997-06-10 Abbott Laboratories Prefilled, two-constituent syringe
US5876372A (en) 1995-03-22 1999-03-02 Abbott Laboratories Syringe system accomodating seperate prefilled barrels for two constituents
US5779668A (en) 1995-03-29 1998-07-14 Abbott Laboratories Syringe barrel for lyophilization, reconstitution and administration
US6638291B1 (en) 1995-04-20 2003-10-28 Micrus Corporation Three dimensional, low friction vasoocclusive coil, and method of manufacture
US6428771B1 (en) 1995-05-15 2002-08-06 Pharmaceutical Discovery Corporation Method for drug delivery to the pulmonary system
US6312407B1 (en) 1995-06-05 2001-11-06 Medtronic Percusurge, Inc. Occlusion of a vessel
US6214331B1 (en) 1995-06-06 2001-04-10 C. R. Bard, Inc. Process for the preparation of aqueous dispersions of particles of water-soluble polymers and the particles obtained
US5624461A (en) 1995-06-06 1997-04-29 Target Therapeutics, Inc. Three dimensional in-filling vaso-occlusive coils
US5766147A (en) 1995-06-07 1998-06-16 Winfield Medical Vial adaptor for a liquid delivery device
US5657756A (en) 1995-06-07 1997-08-19 Ctf Systems Inc. Method and systems for obtaining higher order gradiometer measurements with lower order gradiometers
US6143211A (en) 1995-07-21 2000-11-07 Brown University Foundation Process for preparing microparticles through phase inversion phenomena
US5877224A (en) 1995-07-28 1999-03-02 Rutgers, The State University Of New Jersey Polymeric drug formulations
US5840387A (en) 1995-07-28 1998-11-24 Aegis Biosciences L.L.C. Sulfonated multiblock copolymer and uses therefor
US6096344A (en) 1995-07-28 2000-08-01 Advanced Polymer Systems, Inc. Bioerodible porous compositions
US5558822A (en) 1995-08-16 1996-09-24 Gas Research Institute Method for production of spheroidized particles
US5888546A (en) 1995-08-28 1999-03-30 The Regents Of The University Of California Embolic material for endovascular occlusion of abnormal vasculature and method for using the same
US5833361A (en) 1995-09-07 1998-11-10 Funk; James E. Apparatus for the production of small spherical granules
CA2161863A1 (en) 1995-10-31 1997-05-01 Michael Vivian Sefton Angiogenic material and uses thereof
US5752974A (en) 1995-12-18 1998-05-19 Collagen Corporation Injectable or implantable biomaterials for filling or blocking lumens and voids of the body
PT928182E (en) 1996-01-11 2002-10-31 Duoject Inc DISTRIBUTION SYSTEM FOR PHARMACEUTICAL PRODUCTS PACKED IN PHARMACEUTICAL BOTTLES
US5702361A (en) 1996-01-31 1997-12-30 Micro Therapeutics, Inc. Method for embolizing blood vessels
US5895398A (en) 1996-02-02 1999-04-20 The Regents Of The University Of California Method of using a clot capture coil
US6051247A (en) 1996-05-30 2000-04-18 University Of Florida Research Foundation, Inc. Moldable bioactive compositions
US5855615A (en) 1996-06-07 1999-01-05 Menlo Care, Inc. Controller expansion sphincter augmentation media
US5792478A (en) 1996-07-08 1998-08-11 Advanced Uro Science Tissue injectable composition and method of use
US5980514A (en) 1996-07-26 1999-11-09 Target Therapeutics, Inc. Aneurysm closure device assembly
US5695480A (en) 1996-07-29 1997-12-09 Micro Therapeutics, Inc. Embolizing compositions
US5830178A (en) 1996-10-11 1998-11-03 Micro Therapeutics, Inc. Methods for embolizing vascular sites with an emboilizing composition comprising dimethylsulfoxide
US5741331A (en) 1996-07-29 1998-04-21 Corvita Corporation Biostable elastomeric polymers having quaternary carbons
US5823198A (en) 1996-07-31 1998-10-20 Micro Therapeutics, Inc. Method and apparatus for intravasculer embolization
TW421658B (en) 1996-07-31 2001-02-11 Kanebo Ltd Porious spherical particles and the preparation process for preparing thereof
US5902832A (en) 1996-08-20 1999-05-11 Menlo Care, Inc. Method of synthesizing swollen hydrogel for sphincter augmentation
US5813411A (en) 1996-08-20 1998-09-29 Menlo Care, Inc. Method of deforming tissue with a swollen hydrogel
US5785642A (en) 1996-10-18 1998-07-28 Micro Therapeutics, Inc. Methods for treating urinary incontinence in mammals
US6139963A (en) 1996-11-28 2000-10-31 Kuraray Co., Ltd. Polyvinyl alcohol hydrogel and process for producing the same
US5800454A (en) 1997-03-17 1998-09-01 Sarcos, Inc. Catheter deliverable coiled wire thromboginic apparatus and method
US6090800A (en) 1997-05-06 2000-07-18 Imarx Pharmaceutical Corp. Lipid soluble steroid prodrugs
EP1009684B1 (en) 1997-04-10 2005-09-21 The Johns Hopkins University Gas syringe and package therefor
US6056844A (en) 1997-06-06 2000-05-02 Triton Systems, Inc. Temperature-controlled induction heating of polymeric materials
EP0989870A4 (en) 1997-06-13 2000-08-30 Micro Therapeutics Inc Contoured syringe and novel luer hub and methods for embolizing blood vessels
US6048908A (en) 1997-06-27 2000-04-11 Biopore Corporation Hydrophilic polymeric material
US5959073A (en) 1997-07-07 1999-09-28 Southwest Research Institute Method for preparing polymeric beads
US6056721A (en) 1997-08-08 2000-05-02 Sunscope International, Inc. Balloon catheter and method
WO1999011191A1 (en) 1997-08-28 1999-03-11 Boston Scientific Corporation System for implanting a cross-linked polysaccharide fiber and methods of forming and inserting the fiber
US6322576B1 (en) 1997-08-29 2001-11-27 Target Therapeutics, Inc. Stable coil designs
US6476069B2 (en) 1997-09-11 2002-11-05 Provasis Therapeutics Inc. Compositions for creating embolic agents and uses thereof
US6538026B1 (en) 1997-09-11 2003-03-25 Provasis Therapeutics, Inc. Compositions useful for remodeling body spaces
US6146373A (en) 1997-10-17 2000-11-14 Micro Therapeutics, Inc. Catheter system and method for injection of a liquid embolic composition and a solidification agent
JP4130234B2 (en) 1997-10-30 2008-08-06 株式会社カネカメディックス Medical device for placement of in-vivo indwelling members
CA2307764A1 (en) 1997-11-07 1999-05-20 Salviac Limited Implantable occluder devices for medical use
US5951160A (en) 1997-11-20 1999-09-14 Biomet, Inc. Method and apparatus for packaging, mixing and delivering bone cement
US6019750A (en) 1997-12-04 2000-02-01 Baxter International Inc. Sliding reconstitution device with seal
US6346091B1 (en) 1998-02-13 2002-02-12 Stephen C. Jacobsen Detachable coil for aneurysm therapy
HU222543B1 (en) 1998-02-23 2003-08-28 Massachusetts Institute Of Technology Biodegradable shape memory polymers
PL342996A1 (en) 1998-02-23 2001-07-16 Mnemoscience Gmbh Shape memory polymers
US6003566A (en) 1998-02-26 1999-12-21 Becton Dickinson And Company Vial transferset and method
US6059766A (en) 1998-02-27 2000-05-09 Micro Therapeutics, Inc. Gynecologic embolotherapy methods
US6047861A (en) 1998-04-15 2000-04-11 Vir Engineering, Inc. Two component fluid dispenser
US6224794B1 (en) 1998-05-06 2001-05-01 Angiotech Pharmaceuticals, Inc. Methods for microsphere production
US6224630B1 (en) 1998-05-29 2001-05-01 Advanced Bio Surfaces, Inc. Implantable tissue repair device
WO1999062432A1 (en) 1998-06-04 1999-12-09 New York University Endovascular thin film devices and methods for treating and preventing stroke
US6267154B1 (en) 1998-06-05 2001-07-31 Abbott Laboratories System for storing mixing and administering a drug
US6165193A (en) 1998-07-06 2000-12-26 Microvention, Inc. Vascular embolization with an expansible implant
US6264861B1 (en) 1998-08-05 2001-07-24 Xeikon Nv Method for producing rounded polymeric particles
US6315709B1 (en) 1998-08-07 2001-11-13 Stereotaxis, Inc. Magnetic vascular defect treatment system
US6152943A (en) 1998-08-14 2000-11-28 Incept Llc Methods and apparatus for intraluminal deposition of hydrogels
US6296622B1 (en) 1998-12-21 2001-10-02 Micrus Corporation Endoluminal device delivery system using axially recovering shape memory material
CA2248592A1 (en) 1998-08-31 2000-02-29 Christopher D. Batich Microspheres for use in the treatment of cancer
FR2784580B1 (en) 1998-10-16 2004-06-25 Biosepra Inc POLYVINYL-ALCOHOL MICROSPHERES AND METHODS OF MAKING THE SAME
US6238335B1 (en) 1998-12-11 2001-05-29 Enteric Medical Technologies, Inc. Method for treating gastroesophageal reflux disease and apparatus for use therewith
JP2000189511A (en) 1998-12-25 2000-07-11 Kaneka Medeikkusu:Kk Embolization material
US6162377A (en) 1999-02-23 2000-12-19 Alberta Research Council Inc. Apparatus and method for the formation of uniform spherical particles
US6296604B1 (en) 1999-03-17 2001-10-02 Stereotaxis, Inc. Methods of and compositions for treating vascular defects
US6368658B1 (en) 1999-04-19 2002-04-09 Scimed Life Systems, Inc. Coating medical devices using air suspension
US6280457B1 (en) 1999-06-04 2001-08-28 Scimed Life Systems, Inc. Polymer covered vaso-occlusive devices and methods of producing such devices
US7033603B2 (en) * 1999-08-06 2006-04-25 Board Of Regents The University Of Texas Drug releasing biodegradable fiber for delivery of therapeutics
JP2001079011A (en) 1999-09-14 2001-03-27 Akira Morimoto Embolization coil and its manufacture
US6277392B1 (en) 1999-09-16 2001-08-21 Carbon Medical Technologies, Inc. Tissue injectable composition
US6602261B2 (en) 1999-10-04 2003-08-05 Microvention, Inc. Filamentous embolic device with expansile elements
US6238403B1 (en) 1999-10-04 2001-05-29 Microvention, Inc. Filamentous embolic device with expansible elements
US6790218B2 (en) 1999-12-23 2004-09-14 Swaminathan Jayaraman Occlusive coil manufacture and delivery
KR100335866B1 (en) 2000-01-06 2002-05-10 박호군 Microspheric Embolic Materials Having Duel Structure of Poly(Vinyl Acetate) Core/Poly(Vinyl Alcohol) Shell, and Method for Preparing The Same
US6306419B1 (en) 2000-02-23 2001-10-23 Aegis Biosciences, Llc Medical uses of styrene sulfonate polymers
JP2003525682A (en) 2000-03-06 2003-09-02 シメッド ライフ システムズ インコーポレイテッド Embolic agent visible under ultrasound
DE60130544T2 (en) 2000-03-13 2008-06-26 Biocure, Inc. EMBOLIC COMPOSITIONS
US6652883B2 (en) 2000-03-13 2003-11-25 Biocure, Inc. Tissue bulking and coating compositions
AUPQ677200A0 (en) * 2000-04-07 2000-05-11 Dunstan, David Edwin Production method
US6969480B2 (en) * 2000-05-12 2005-11-29 Matregen Corp. Method of producing structures using centrifugal forces
US6423332B1 (en) 2000-05-26 2002-07-23 Ethicon, Inc. Method and composition for deforming soft tissues
DE10026620A1 (en) 2000-05-29 2002-03-07 Gerhard Quelle Biocompatible material for cell and tissue implantation, useful e.g. for drug release or cosmetic tissue augmentation, consisting of spherical particles having (semi-)permeable or porous outer shell and internal cavity
US6355275B1 (en) 2000-06-23 2002-03-12 Carbon Medical Technologies, Inc. Embolization using carbon coated microparticles
JP2002017848A (en) 2000-07-12 2002-01-22 Terumo Corp Intravitally injectable particulate and method for preparing the same
WO2002013786A2 (en) 2000-08-15 2002-02-21 Board Of Trustees Of The University Of Illinois Method of forming microparticles
US6394965B1 (en) 2000-08-15 2002-05-28 Carbon Medical Technologies, Inc. Tissue marking using biocompatible microparticles
US6635069B1 (en) 2000-10-18 2003-10-21 Scimed Life Systems, Inc. Non-overlapping spherical three-dimensional coil
AUPR098300A0 (en) 2000-10-25 2000-11-16 Sirtex Medical Limited Polymer based radionuclide containing microspheres
AUPR098200A0 (en) 2000-10-25 2000-11-16 Sirtex Medical Limited Production of low density radionuclide containing microspheres
US6545097B2 (en) 2000-12-12 2003-04-08 Scimed Life Systems, Inc. Drug delivery compositions and medical devices containing block copolymer
US6669652B2 (en) 2000-12-21 2003-12-30 Advanced Cardiovascular Systems, Inc. Guidewire with tapered distal coil
US6632531B2 (en) 2001-02-15 2003-10-14 Rohm And Haas Company Porous particles, their aqueous dispersions, and method of preparation
US20030032935A1 (en) 2001-08-10 2003-02-13 Scimed Life Systems, Inc. Packages facilitating convenient mixing and delivery of liquids
US7218962B2 (en) 2002-03-29 2007-05-15 Boston Scientific Scimed, Inc. Magnetically enhanced injection catheter
US7462366B2 (en) 2002-03-29 2008-12-09 Boston Scientific Scimed, Inc. Drug delivery particle
US7094369B2 (en) 2002-03-29 2006-08-22 Scimed Life Systems, Inc. Processes for manufacturing polymeric microspheres
US7131997B2 (en) 2002-03-29 2006-11-07 Scimed Life Systems, Inc. Tissue treatment
US7053134B2 (en) 2002-04-04 2006-05-30 Scimed Life Systems, Inc. Forming a chemically cross-linked particle of a desired shape and diameter
US7838699B2 (en) 2002-05-08 2010-11-23 Biosphere Medical Embolization using degradable crosslinked hydrogels
WO2004011076A2 (en) 2002-07-25 2004-02-05 Boston Scientific Limited Medical device for navigation through anatomy and method of making same
US20040076582A1 (en) 2002-08-30 2004-04-22 Dimatteo Kristian Agent delivery particle
US7449236B2 (en) * 2002-08-09 2008-11-11 Boston Scientific Scimed, Inc. Porous polymeric particle comprising polyvinyl alcohol and having interior to surface porosity-gradient
US8012454B2 (en) 2002-08-30 2011-09-06 Boston Scientific Scimed, Inc. Embolization
US7588825B2 (en) 2002-10-23 2009-09-15 Boston Scientific Scimed, Inc. Embolic compositions
US7883490B2 (en) 2002-10-23 2011-02-08 Boston Scientific Scimed, Inc. Mixing and delivery of therapeutic compositions
DE10257219B3 (en) 2002-12-07 2004-06-03 Frank Dr. Czerwinski Implantation of occlusion elements comprises transition section with distal end fixed to endovascular guide, and transition enclosed by helical compression spring, and nominal fracture point
US20040115164A1 (en) 2002-12-17 2004-06-17 Pierce Ryan K. Soft filament occlusive device delivery system
US7792568B2 (en) 2003-03-17 2010-09-07 Boston Scientific Scimed, Inc. MRI-visible medical devices
US7906148B2 (en) 2003-07-31 2011-03-15 Boston Scientific Scimed, Inc. Latex medical articles for release of antimicrobial agents
US20050037047A1 (en) 2003-08-11 2005-02-17 Young-Ho Song Medical devices comprising spray dried microparticles
US7976823B2 (en) 2003-08-29 2011-07-12 Boston Scientific Scimed, Inc. Ferromagnetic particles and methods
US7901770B2 (en) 2003-11-04 2011-03-08 Boston Scientific Scimed, Inc. Embolic compositions
US7736671B2 (en) 2004-03-02 2010-06-15 Boston Scientific Scimed, Inc. Embolization
US8173176B2 (en) 2004-03-30 2012-05-08 Boston Scientific Scimed, Inc. Embolization
US20050238870A1 (en) 2004-04-22 2005-10-27 Marcia Buiser Embolization
US7311861B2 (en) 2004-06-01 2007-12-25 Boston Scientific Scimed, Inc. Embolization
US20060025802A1 (en) 2004-07-30 2006-02-02 Sowers William W Embolic coil delivery system with U-shaped fiber release mechanism
US20060025801A1 (en) 2004-07-30 2006-02-02 Robert Lulo Embolic device deployment system with filament release
US20060045900A1 (en) 2004-08-27 2006-03-02 Robert Richard Embolization
US8425550B2 (en) 2004-12-01 2013-04-23 Boston Scientific Scimed, Inc. Embolic coils
US7858183B2 (en) 2005-03-02 2010-12-28 Boston Scientific Scimed, Inc. Particles
US7727555B2 (en) 2005-03-02 2010-06-01 Boston Scientific Scimed, Inc. Particles
US7963287B2 (en) 2005-04-28 2011-06-21 Boston Scientific Scimed, Inc. Tissue-treatment methods
US20070004973A1 (en) 2005-06-15 2007-01-04 Tan Sharon M L Tissue treatment methods
US9463426B2 (en) 2005-06-24 2016-10-11 Boston Scientific Scimed, Inc. Methods and systems for coating particles
US20070083219A1 (en) 2005-10-12 2007-04-12 Buiser Marcia S Embolic coil introducer sheath locking mechanisms
US8007509B2 (en) 2005-10-12 2011-08-30 Boston Scientific Scimed, Inc. Coil assemblies, components and methods
US20070142859A1 (en) 2005-12-19 2007-06-21 Boston Scientific Scimed, Inc. Embolic coils
US8152839B2 (en) 2005-12-19 2012-04-10 Boston Scientific Scimed, Inc. Embolic coils

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5614204A (en) * 1995-01-23 1997-03-25 The Regents Of The University Of California Angiographic vascular occlusion agents and a method for hemostatic occlusion
US6117142A (en) * 1998-03-10 2000-09-12 Cordis Corporation Embolic coil hydraulic deployment system with improved syringe injector
US20040093014A1 (en) * 1998-11-10 2004-05-13 Hanh Ho Bioactive components for incorporation with vaso-occlusive members
US20010031978A1 (en) * 2000-02-03 2001-10-18 Kipke Daryl R. Method for forming an endovascular occlusion
US20020143348A1 (en) * 2001-03-30 2002-10-03 Wallace Michael P. Embolic devices capable of in-situ reinforcement
US20050133046A1 (en) * 2003-12-17 2005-06-23 Becker Timothy A. Compositions and methods for improved occlusion of vascular defects
EP1547530A1 (en) * 2003-12-17 2005-06-29 Cordis Neurovascular, Inc. Activatable bioactive vascular occlusive device and method of use
EP1738695A1 (en) * 2005-06-30 2007-01-03 Cordis Development Corporation Method of making a coated embolization device

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
KRYSL J ET AL: "Embolization agents: A review", TECHNIQUES IN VASCULAR AND INTERVENTIONAL RADIOLOGY, vol. 3, no. 3, September 2000 (2000-09-01), pages 158 - 161, XP004624533, ISSN: 1089-2516 *
LANZINO GIUSEPPE ET AL: "Emerging concepts in the treatment of intracranial aneurysms: Stents, coatedcoils, and liquid embolic agents", NEUROSURGERY, WILLIAMS & WILKINS, BALTIMORE, MD, US, vol. 57, no. 3, September 2005 (2005-09-01), pages 449 - 458, XP009087737, ISSN: 0148-396X *

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