WO2007067561A3 - Porous calcium phosphate bone material - Google Patents

Porous calcium phosphate bone material Download PDF

Info

Publication number
WO2007067561A3
WO2007067561A3 PCT/US2006/046435 US2006046435W WO2007067561A3 WO 2007067561 A3 WO2007067561 A3 WO 2007067561A3 US 2006046435 W US2006046435 W US 2006046435W WO 2007067561 A3 WO2007067561 A3 WO 2007067561A3
Authority
WO
WIPO (PCT)
Prior art keywords
calcium phosphate
compositions
porous calcium
bone material
phosphate bone
Prior art date
Application number
PCT/US2006/046435
Other languages
French (fr)
Other versions
WO2007067561A2 (en
Inventor
Aron D Rosenberg
De Pelichy Laurent D Gilles
Shrikar Bondre
Michael Strunk
Original Assignee
Etex Corp
Aron D Rosenberg
De Pelichy Laurent D Gilles
Shrikar Bondre
Michael Strunk
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Etex Corp, Aron D Rosenberg, De Pelichy Laurent D Gilles, Shrikar Bondre, Michael Strunk filed Critical Etex Corp
Priority to EP06844849.7A priority Critical patent/EP1962716B1/en
Priority to CN2006800520527A priority patent/CN101420922B/en
Priority to KR1020087016283A priority patent/KR101395884B1/en
Priority to JP2008544447A priority patent/JP5416972B2/en
Priority to AU2006322025A priority patent/AU2006322025B2/en
Priority to CA2632785A priority patent/CA2632785C/en
Publication of WO2007067561A2 publication Critical patent/WO2007067561A2/en
Publication of WO2007067561A3 publication Critical patent/WO2007067561A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/54—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/28—Bones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/1875—Bone morphogenic factor; Osteogenins; Osteogenic factor; Bone-inducing factor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/02—Inorganic materials
    • A61L27/12—Phosphorus-containing materials, e.g. apatite
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/56—Porous materials, e.g. foams or sponges
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
    • A61L2300/252—Polypeptides, proteins, e.g. glycoproteins, lipoproteins, cytokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
    • A61L2300/252—Polypeptides, proteins, e.g. glycoproteins, lipoproteins, cytokines
    • A61L2300/256—Antibodies, e.g. immunoglobulins, vaccines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
    • A61L2300/406—Antibiotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/412—Tissue-regenerating or healing or proliferative agents
    • A61L2300/414—Growth factors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/416—Anti-neoplastic or anti-proliferative or anti-restenosis or anti-angiogenic agents, e.g. paclitaxel, sirolimus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/432—Inhibitors, antagonists
    • A61L2300/434—Inhibitors, antagonists of enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/02—Materials or treatment for tissue regeneration for reconstruction of bones; weight-bearing implants

Abstract

Porous calcium phosphate implant compositions that approximate the chemical composition of natural bone mineral are provided. In addition to calcium phosphate, the compositions include an effervescent agent to promote the formation of interconnected pores and a cohesiveness agent to maintain the shape and hardness of the hardened composition. When introduced at an implant site, the calcium phosphate compositions are remodeled into bone. Methods for using the calcium phosphate compositions, e.g., to repair or replace bone, are also provided.
PCT/US2006/046435 2005-12-06 2006-12-06 Porous calcium phosphate bone material WO2007067561A2 (en)

Priority Applications (6)

Application Number Priority Date Filing Date Title
EP06844849.7A EP1962716B1 (en) 2005-12-06 2006-12-06 Porous calcium phosphate bone material
CN2006800520527A CN101420922B (en) 2005-12-06 2006-12-06 Porous calcium phosphate bone material
KR1020087016283A KR101395884B1 (en) 2005-12-06 2006-12-06 Porous Calcium Phosphate Bone Material
JP2008544447A JP5416972B2 (en) 2005-12-06 2006-12-06 Porous calcium phosphate bone material
AU2006322025A AU2006322025B2 (en) 2005-12-06 2006-12-06 Porous calcium phosphate bone material
CA2632785A CA2632785C (en) 2005-12-06 2006-12-06 Porous calcium phosphate bone material formed from a precursor composition comprising calcium phosphate, an effervescent agent and a cohesiveness agent

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US11/294,819 US8147860B2 (en) 2005-12-06 2005-12-06 Porous calcium phosphate bone material
US11/294,819 2005-12-06

Publications (2)

Publication Number Publication Date
WO2007067561A2 WO2007067561A2 (en) 2007-06-14
WO2007067561A3 true WO2007067561A3 (en) 2007-10-11

Family

ID=38119036

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2006/046435 WO2007067561A2 (en) 2005-12-06 2006-12-06 Porous calcium phosphate bone material

Country Status (8)

Country Link
US (2) US8147860B2 (en)
EP (2) EP1962716B1 (en)
JP (1) JP5416972B2 (en)
KR (1) KR101395884B1 (en)
CN (1) CN101420922B (en)
AU (1) AU2006322025B2 (en)
CA (1) CA2632785C (en)
WO (1) WO2007067561A2 (en)

Families Citing this family (115)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7713297B2 (en) 1998-04-11 2010-05-11 Boston Scientific Scimed, Inc. Drug-releasing stent with ceramic-containing layer
DE10032220A1 (en) * 2000-07-03 2002-01-24 Sanatis Gmbh Magnesium ammonium phosphate cements, their manufacture and use
US7273523B2 (en) * 2002-06-07 2007-09-25 Kyphon Inc. Strontium-apatite-cement-preparations, cements formed therefrom, and uses thereof
US8168692B2 (en) 2004-04-27 2012-05-01 Kyphon Sarl Bone substitute compositions and method of use
US20060127443A1 (en) * 2004-12-09 2006-06-15 Helmus Michael N Medical devices having vapor deposited nanoporous coatings for controlled therapeutic agent delivery
US7651701B2 (en) * 2005-08-29 2010-01-26 Sanatis Gmbh Bone cement composition and method of making the same
US8147860B2 (en) * 2005-12-06 2012-04-03 Etex Corporation Porous calcium phosphate bone material
EP2001528A4 (en) * 2006-03-23 2012-04-04 Citagenix Inc Reverse phase osteoconductive composition
US20070224235A1 (en) 2006-03-24 2007-09-27 Barron Tenney Medical devices having nanoporous coatings for controlled therapeutic agent delivery
US8187620B2 (en) 2006-03-27 2012-05-29 Boston Scientific Scimed, Inc. Medical devices comprising a porous metal oxide or metal material and a polymer coating for delivering therapeutic agents
US7754005B2 (en) * 2006-05-02 2010-07-13 Kyphon Sarl Bone cement compositions comprising an indicator agent and related methods thereof
US7507286B2 (en) * 2006-06-08 2009-03-24 Sanatis Gmbh Self-foaming cement for void filling and/or delivery systems
US8815275B2 (en) 2006-06-28 2014-08-26 Boston Scientific Scimed, Inc. Coatings for medical devices comprising a therapeutic agent and a metallic material
US8771343B2 (en) 2006-06-29 2014-07-08 Boston Scientific Scimed, Inc. Medical devices with selective titanium oxide coatings
DE102006042142A1 (en) * 2006-09-06 2008-03-27 Curasan Ag Phase- and sedimentation-stable, plastically deformable preparation with intrinsic pore formation, for example for filling bone defects or for use as a bone substitute material, and method for their preparation
WO2008033711A2 (en) 2006-09-14 2008-03-20 Boston Scientific Limited Medical devices with drug-eluting coating
AU2007300585A1 (en) * 2006-09-21 2008-04-03 Kyphon Sarl Diammonium phosphate and other ammonium salts and their use in preventing clotting
WO2008073190A2 (en) * 2006-11-03 2008-06-19 Kyphon Sarl Materials and methods and systems for delivering localized medical treatments
US7981150B2 (en) * 2006-11-09 2011-07-19 Boston Scientific Scimed, Inc. Endoprosthesis with coatings
US20080294236A1 (en) * 2007-05-23 2008-11-27 Boston Scientific Scimed, Inc. Endoprosthesis with Select Ceramic and Polymer Coatings
US8431149B2 (en) * 2007-03-01 2013-04-30 Boston Scientific Scimed, Inc. Coated medical devices for abluminal drug delivery
US8070797B2 (en) 2007-03-01 2011-12-06 Boston Scientific Scimed, Inc. Medical device with a porous surface for delivery of a therapeutic agent
US8067054B2 (en) 2007-04-05 2011-11-29 Boston Scientific Scimed, Inc. Stents with ceramic drug reservoir layer and methods of making and using the same
US7976915B2 (en) 2007-05-23 2011-07-12 Boston Scientific Scimed, Inc. Endoprosthesis with select ceramic morphology
US7942926B2 (en) 2007-07-11 2011-05-17 Boston Scientific Scimed, Inc. Endoprosthesis coating
US8002823B2 (en) 2007-07-11 2011-08-23 Boston Scientific Scimed, Inc. Endoprosthesis coating
US9284409B2 (en) 2007-07-19 2016-03-15 Boston Scientific Scimed, Inc. Endoprosthesis having a non-fouling surface
US7931683B2 (en) 2007-07-27 2011-04-26 Boston Scientific Scimed, Inc. Articles having ceramic coated surfaces
US8815273B2 (en) 2007-07-27 2014-08-26 Boston Scientific Scimed, Inc. Drug eluting medical devices having porous layers
US8221822B2 (en) 2007-07-31 2012-07-17 Boston Scientific Scimed, Inc. Medical device coating by laser cladding
JP5210566B2 (en) * 2007-08-01 2013-06-12 日本特殊陶業株式会社 Biological implant and method for producing the same
WO2009020520A1 (en) 2007-08-03 2009-02-12 Boston Scientific Scimed, Inc. Coating for medical device having increased surface area
WO2009052583A1 (en) * 2007-10-24 2009-04-30 The University Of Sydney Biocompatible material and uses thereof
US8029554B2 (en) 2007-11-02 2011-10-04 Boston Scientific Scimed, Inc. Stent with embedded material
US8216632B2 (en) 2007-11-02 2012-07-10 Boston Scientific Scimed, Inc. Endoprosthesis coating
US7938855B2 (en) 2007-11-02 2011-05-10 Boston Scientific Scimed, Inc. Deformable underlayer for stent
US20090118821A1 (en) * 2007-11-02 2009-05-07 Boston Scientific Scimed, Inc. Endoprosthesis with porous reservoir and non-polymer diffusion layer
CA2711900A1 (en) * 2008-01-09 2009-07-16 Oswestry Tissue Bank Ltd Bone repair composition and a method of making the same
US20090286907A1 (en) * 2008-01-23 2009-11-19 Beltz Mark W Fumaric Acid/Diol Polyesters and Their Manufacture and Use
AU2009236216B2 (en) 2008-04-15 2015-05-21 Life Science Enterprises, Inc. Minimally invasive treatment of vertebra (MITV) using a calcium phosphate combination bone cement
AU2015215892B2 (en) * 2008-04-15 2017-11-30 Life Science Enterprises, Inc. Minimally invasive treatment of vertebra (mitv) using a calcium phosphate combination bone cement
US7968616B2 (en) * 2008-04-22 2011-06-28 Kyphon Sarl Bone cement composition and method
JP5581311B2 (en) 2008-04-22 2014-08-27 ボストン サイエンティフィック サイムド，インコーポレイテッド MEDICAL DEVICE HAVING INORGANIC MATERIAL COATING AND MANUFACTURING METHOD THEREOF
US8932346B2 (en) 2008-04-24 2015-01-13 Boston Scientific Scimed, Inc. Medical devices having inorganic particle layers
WO2009155328A2 (en) 2008-06-18 2009-12-23 Boston Scientific Scimed, Inc. Endoprosthesis coating
US8608801B2 (en) * 2008-07-06 2013-12-17 The Trustees Of Columbia University In The City Of New York Osteochondral implants, arthroplasty methods, devices, and systems
KR100937736B1 (en) * 2008-09-23 2010-01-21 동국대학교 산학협력단 Porous support for guided tissue regeneration and a method of manufacturing same
CN101417149B (en) * 2008-10-22 2012-11-21 四川大学 Degradable biological composite material of phosphate containing calcium and preparation method thereof
US8231980B2 (en) 2008-12-03 2012-07-31 Boston Scientific Scimed, Inc. Medical implants including iridium oxide
US8673364B2 (en) * 2009-09-28 2014-03-18 Skeletal Kinetics, Llc Rapid setting high strength calcium phosphate cements comprising cyclodextrins
US8409538B2 (en) 2008-12-04 2013-04-02 Skeletal Kinetics Llc Tricalcium phosphate coarse particle compositions and methods for making the same
US8071156B2 (en) 2009-03-04 2011-12-06 Boston Scientific Scimed, Inc. Endoprostheses
JPWO2010119897A1 (en) * 2009-04-17 2012-10-22 Hoya株式会社 Calcium phosphate cement composition for bone filling material and kit thereof
US8287937B2 (en) 2009-04-24 2012-10-16 Boston Scientific Scimed, Inc. Endoprosthese
US20110243913A1 (en) * 2010-04-06 2011-10-06 Orthovita, Inc. Biomaterial Compositions and Methods of Use
EP2637983B1 (en) 2010-11-10 2018-12-26 Stryker European Holdings I, LLC Process for the preparation of a polymeric bone foam
CN103781485A (en) * 2011-01-19 2014-05-07 护肤品实验室有限公司 Topical minocycline compositions and methods of using the same
CN102133154B (en) * 2011-03-09 2012-09-19 东南大学 Root apex filling material and preparation method thereof
KR101375828B1 (en) 2011-03-31 2014-03-17 인제대학교 산학협력단 Complex Scaffold For Bone-Cartilage Regeneration, Method For Preparing Thereof And Composition for Treating Bone Cartilage Disease Comprising The Same
EP2708246B1 (en) 2011-05-13 2017-11-01 School Juridical Person Kitasato Institute Growth factor anchoring type bone graft material, method for producing growth factor anchoring type bone graft material, kit for producing growth factor anchoring type bone graft material.
KR101364312B1 (en) * 2011-07-15 2014-02-19 단국대학교 산학협력단 A preparation method of alginate microfibers
CN103127547B (en) * 2011-11-28 2015-04-01 成功大学 Reinforced non-disintegrative calcium-based bone cement preparation
US10207027B2 (en) * 2012-06-11 2019-02-19 Globus Medical, Inc. Bioactive bone graft substitutes
US20150148292A1 (en) * 2012-07-09 2015-05-28 Emory University Bone morphogenetic protein pathway activation, compositions for ossification, and methods related thereto
KR101309528B1 (en) * 2013-01-11 2013-09-24 군산대학교산학협력단 Preparing method for bone composite, bone composite prepared thereby, and artificial bone containing the bone composite
WO2014148997A1 (en) * 2013-03-22 2014-09-25 Biomatcell Ab Hollow calcium phosphate particles
US9539286B2 (en) 2013-10-18 2017-01-10 Globus Medical, Inc. Bone grafts including osteogenic stem cells, and methods relating to the same
US9486483B2 (en) 2013-10-18 2016-11-08 Globus Medical, Inc. Bone grafts including osteogenic stem cells, and methods relating to the same
CN103655209B (en) * 2013-12-04 2015-08-19 天津医科大学口腔医院 The composite of tooth hard tissue remineralization
CN104771782A (en) * 2014-01-10 2015-07-15 东莞博捷生物科技有限公司 Bone repair material beta-tricalcium phosphate and preparation method thereof
US9579421B2 (en) 2014-02-07 2017-02-28 Globus Medical Inc. Bone grafts and methods of making and using bone grafts
US9463264B2 (en) 2014-02-11 2016-10-11 Globus Medical, Inc. Bone grafts and methods of making and using bone grafts
CN104147641B (en) * 2014-07-11 2016-08-31 深圳职业技术学院 A kind of for personalized bone renovating material and its preparation method
KR20190008432A (en) * 2014-11-27 2019-01-23 도요보 가부시키가이샤 Porous composite body, bone regeneration material, and method for producing porous composite body
CN104523341B (en) * 2014-12-18 2017-06-20 中国人民解放军第四军医大学 The manufacture method of the immediate implantation teeth with periodontal bioactivity
CN104841011B (en) * 2015-01-25 2017-01-04 宁波开发区中心医院 The preparation method of biodegradable block copolymer-calcium silicates composite bone repairing material
US10219986B2 (en) 2015-03-04 2019-03-05 Modern Ideas LLC Stabilized calcium phosphate and methods of forming same
US10195305B2 (en) * 2015-03-24 2019-02-05 Orthovita, Inc. Bioactive flowable wash-out resistant bone graft material and method for production thereof
CN104771785B (en) * 2015-04-03 2017-06-20 周宏志 The manufacture method of the bone renovating material with nerve polypeptide induced osteogenesis activity
US10016529B2 (en) 2015-06-10 2018-07-10 Globus Medical, Inc. Biomaterial compositions, implants, and methods of making the same
US11426489B2 (en) 2015-06-10 2022-08-30 Globus Medical, Inc. Biomaterial compositions, implants, and methods of making the same
CN106334214B (en) * 2015-07-13 2019-11-12 中南大学 A kind of multiple liquid phase construction method towards the preparation of calcium phosphate active ceramic bone bracket
CN105153612A (en) * 2015-08-31 2015-12-16 苏州莱特复合材料有限公司 Composite material for orthopedic braces and preparation method of composite material
WO2017062737A1 (en) * 2015-10-08 2017-04-13 Zimmer Knee Creations, Inc. Curable calcium phosphate compositions for use with porous structures and methods of using the same
US9956314B2 (en) 2016-01-26 2018-05-01 Modern Ideas LLC Adhesive for use with bone and bone-like structures
JP2016209599A (en) * 2016-05-20 2016-12-15 ライフ サイエンス エンタープライジズ インコーポレイテッド Minimally invasive treatment of vertebra (mitv) using calcium phosphate combination bone cement
WO2017209136A1 (en) * 2016-05-30 2017-12-07 富士フイルム株式会社 Method for producing calcium phosphate molded article, calcium phosphate molded article, and material for transplantation
CN106178063B (en) * 2016-08-14 2019-09-27 山东省芙蓉堂制药有限公司 A kind of no immunological rejection adhesive bandage
ES2959245T3 (en) 2016-10-28 2024-02-22 Cellink Bioprinting Ab Preparation and applications of bioinks for 3D bioprinting for the repair of bone defects, based on cellulose nanofibril hydrogels with natural or synthetic calcium phosphate particles
WO2018078130A1 (en) 2016-10-28 2018-05-03 Paul Gatenholm Preparation and applications of 3d bioprinting bioinks for repair of bone defects, based on cellulose nanofibrils hydrogels with natural or synthetic calcium phosphate particles
CN107551319A (en) * 2017-07-13 2018-01-09 吉林大学 A kind of preparation method of anti-bone tumor composite bone reconstruction bracket
CN107648673B (en) * 2017-09-18 2020-12-11 暨南大学 Composite calcium phosphate cement and preparation method and application thereof
CN108309517B (en) * 2018-01-25 2019-08-30 中国人民解放军新疆军区总医院 A kind of absorbable cervical fusion cage and preparation method thereof
KR101959523B1 (en) * 2018-01-30 2019-03-18 주식회사 파마리서치프로덕트 Composition comprising nucleic acids, bone graft materials and cationic polymers for bone grafting and kit for manufacturing the same
US20190314550A1 (en) * 2018-04-16 2019-10-17 Brahm Holdings, Llc Bone substitute composition and related methods
WO2020008555A1 (en) * 2018-07-04 2020-01-09 オリンパス株式会社 Bone substitute and method for producing bone substitute
WO2020008558A1 (en) * 2018-07-04 2020-01-09 オリンパス株式会社 Bone substitute and method for producing bone substitute
CN109260511A (en) * 2018-09-14 2019-01-25 广州润虹医药科技股份有限公司 A kind of Injectable porous calcium phosphate bone cement and preparation method thereof
CN109316627A (en) * 2018-10-26 2019-02-12 中国医学科学院北京协和医院 A kind of novel artificial bone material and its preparation method and application
CN109847095A (en) * 2018-12-28 2019-06-07 上海纳米技术及应用国家工程研究中心有限公司 The preparation of PEG cladding photosensitizer IR780 modified Injectable calcium-phosphate bone cement and product and application
CN109980200B (en) * 2019-03-21 2021-01-15 北京工业大学 Amorphous phosphorus-based negative electrode material with dispersed crystal domains and preparation method thereof
CN109985277B (en) * 2019-03-27 2021-09-14 广东工业大学 Porous hydroxyapatite/chitosan composite material scaffold for bone tissue engineering and preparation method thereof
CN110201228A (en) * 2019-04-19 2019-09-06 湖北联结生物材料有限公司 A kind of calcium phosphate bone cement and its preparation method and application containing decalcified bone matrix
CN110101906B (en) * 2019-05-31 2021-08-06 西安理工大学 Injectable PMMA (polymethyl methacrylate) antibiotic bone cement and preparation method thereof
US20220232821A1 (en) * 2019-06-07 2022-07-28 University Of Cincinnati Red blood cell storage solutions, additives, and methods for improving the storage of red blood cells using inorganic pyrophosphates
KR102307234B1 (en) * 2019-07-09 2021-10-01 나태용 Bone cement composition for periodontal tissue
WO2021029525A1 (en) * 2019-08-14 2021-02-18 주식회사 메드파크 Bone graft composition and preparation method therefor
KR102196235B1 (en) * 2019-08-14 2020-12-29 (주)메드파크 Composition for bone defect and preparation method of the same and kit for the same
CN114096289B (en) * 2019-10-30 2023-09-01 爱恩斯生物科技(昆山)有限公司 Composite decalcified bone composition containing bone inorganic matter component and preparation method thereof
CN113049839B (en) * 2019-12-27 2022-11-29 桂林英美特生物技术研究所 Stable liver function composite quality control product
CN113456886B (en) * 2020-03-31 2023-07-18 中国人民解放军第四军医大学 Nucleic acid-calcium phosphate nanoparticle complexes and their use in biomineralization
US11896736B2 (en) 2020-07-13 2024-02-13 Globus Medical, Inc Biomaterial implants and methods of making the same
CN112028698B (en) * 2020-08-27 2022-08-12 中南林业科技大学 Preparation method of hydroxyapatite-based nano-scale slow-release nitrogen fertilizer
CN113368298B (en) * 2021-06-09 2022-07-15 刘长城 Medical orthopedic adhesive material with antibacterial effect and preparation method thereof
CN113350486A (en) * 2021-07-06 2021-09-07 深圳市人民医院 Pharmaceutical composition with bone defect repairing effect and application thereof

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020187104A1 (en) * 2001-06-08 2002-12-12 Wyeth Calcuim phosphate delivery vehicles for osteoinductive proteins
US20030180344A1 (en) * 2002-02-05 2003-09-25 Cambridge Scientific, Inc. Bioresorbable osteoconductive compositions for bone regeneration
US20050084542A1 (en) * 2003-04-11 2005-04-21 Rosenberg Aron D. Osteoinductive bone material

Family Cites Families (139)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2967802A (en) 1957-12-02 1961-01-10 Diamond Lab Hydrated calcium phosphate gelantigen composition and method of preparing same
FR1604134A (en) 1967-09-26 1971-07-12
US3577492A (en) 1967-10-02 1971-05-04 Miles Lab Tableting lubricant
US4016252A (en) 1972-04-06 1977-04-05 Institut Pasteur Calcium phosphate gel for adsorbing vaccines
FR2181426B1 (en) 1972-04-06 1974-12-20 Pasteur Institut
US4157378A (en) 1973-01-11 1979-06-05 Colgate Palmolive Company Process for preparing fluorapatite
DK248775A (en) 1974-06-04 1975-12-05 Wellcome Found PROCEDURE FOR PREPARING CONJUGATES OF PROSTAGLANDINS AND PROSTAGLANDIN ANALOG
CH611150A5 (en) * 1975-04-18 1979-05-31 Sulzer Ag
US4108690A (en) 1976-04-05 1978-08-22 Amchem Products, Inc. Method for producing an amorphous, light weight calcium phosphate coating on ferrous metal surfaces
DE2843963A1 (en) 1978-10-09 1980-04-24 Merck Patent Gmbh BODY-RESORBABLE SHAPED MATERIAL BASED ON COLLAGEN AND THEIR USE IN MEDICINE
EP0007895B1 (en) 1978-07-19 1983-06-22 Patrick Couvreur Biodegradable nanoparticles, pharmaceutical compositions containing them and process for their preparation
JPS5654841A (en) 1979-10-08 1981-05-15 Mitsubishi Mining & Cement Co Bone broken portion and filler for void portion and method of treating bone of animal using said filler
US4346709A (en) 1980-11-10 1982-08-31 Alza Corporation Drug delivery devices comprising erodible polymer and erosion rate modifier
US4353888A (en) 1980-12-23 1982-10-12 Sefton Michael V Encapsulation of live animal cells
USRE33221E (en) 1982-04-29 1990-05-22 American Dental Association Health Foundation Dental restorative cement pastes
USRE33161E (en) 1982-04-29 1990-02-06 American Dental Association Health Foundation Combinations of sparingly soluble calcium phosphates in slurries and pastes as mineralizers and cements
US5286763A (en) 1983-03-22 1994-02-15 Massachusetts Institute Of Technology Bioerodible polymers for drug delivery in bone
JPS59170700U (en) 1983-04-30 1984-11-15 株式会社荏原製作所 Strainer
DE3325111A1 (en) 1983-07-12 1985-01-24 Merck Patent Gmbh, 6100 Darmstadt IMPLANTATION MATERIALS
US4612053A (en) 1983-10-06 1986-09-16 American Dental Association Health Foundation Combinations of sparingly soluble calcium phosphates in slurries and pastes as mineralizers and cements
JPS6117409A (en) 1984-07-02 1986-01-25 Meishin Toryo Kk Preparation of amorphous calcium phosphate and bio-compatible composition composed mainly thereof
US4620327A (en) 1984-07-05 1986-11-04 Caplan Arnold I Process of adapting soluble bone protein for use in stimulating osteoinduction
DE3433210C1 (en) 1984-09-10 1986-06-05 Hans Dr.med. Dr.med.dent. 8000 München Scheicher Means for filling bone and tooth defects, for bone building, for bone contact layers and for bone and tooth root replacement and use of carbonate apatite for this purpose
US5007930A (en) 1985-02-19 1991-04-16 The Dow Chemical Company Composites of unsintered calcium phosphates and synthetic biodegradable polymers useful as hard tissue prosthetics
JPS62182146A (en) 1985-10-11 1987-08-10 三井東圧化学株式会社 Hardenable material
US5187076A (en) 1986-07-01 1993-02-16 Genetics Institute, Inc. DNA sequences encoding BMP-6 proteins
US5108922A (en) 1986-07-01 1992-04-28 Genetics Institute, Inc. DNA sequences encoding BMP-1 products
US5106748A (en) 1986-07-01 1992-04-21 Genetics Institute, Inc. Dna sequences encoding 5 proteins
US5013649A (en) 1986-07-01 1991-05-07 Genetics Institute, Inc. DNA sequences encoding osteoinductive products
ZA874681B (en) 1986-07-01 1988-04-27 Genetics Inst Novel osteoinductive factors
US4778471A (en) 1986-11-19 1988-10-18 University Of Dayton Zcap ceramics
US5041138A (en) 1986-11-20 1991-08-20 Massachusetts Institute Of Technology Neomorphogenesis of cartilage in vivo from cell culture
US4737411A (en) 1986-11-25 1988-04-12 University Of Dayton Controlled pore size ceramics particularly for orthopaedic and dental applications
US5085861A (en) 1987-03-12 1992-02-04 The Beth Israel Hospital Association Bioerodable implant composition comprising crosslinked biodegradable polyesters
DE3709897A1 (en) 1987-03-26 1988-10-06 Ewers Rolf METHOD OF MANUFACTURING A HYDROXYLAPATITE MATERIAL
US4892538A (en) 1987-11-17 1990-01-09 Brown University Research Foundation In vivo delivery of neurotransmitters by implanted, encapsulated cells
US4880610A (en) 1988-04-20 1989-11-14 Norian Corporation In situ calcium phosphate minerals--method and composition
US5962028A (en) 1988-04-20 1999-10-05 Norian Corporation Carbonated hydroxyapatite compositions and uses
US5129905A (en) 1988-04-20 1992-07-14 Norian Corporation Methods for in situ prepared calcium phosphate minerals
US6005162A (en) 1988-04-20 1999-12-21 Norian Corporation Methods of repairing bone
US5053212A (en) 1988-04-20 1991-10-01 Norian Corporation Intimate mixture of calcium and phosphate sources as precursor to hydroxyapatite
US6002065A (en) 1988-04-20 1999-12-14 Norian Corporation Kits for preparing calcium phosphate minerals
US5047031A (en) 1988-04-20 1991-09-10 Norian Corporation In situ calcium phosphate minerals method
US5178845A (en) 1988-04-20 1993-01-12 Norian Corporation Intimate mixture of calcium and phosphate sources as precursor to hydroxyapatite
US4849193A (en) 1988-05-02 1989-07-18 United States Gypsum Company Process of preparing hydroxylapatite
US5034059A (en) 1989-02-17 1991-07-23 Norian Corporation Composition comprising octacalcium phosphate crystals and polypeptide
US5037639A (en) 1989-05-24 1991-08-06 American Dental Association Health Foundation Methods and compositions for mineralizing calcified tissues
US5290558A (en) 1989-09-21 1994-03-01 Osteotech, Inc. Flowable demineralized bone powder composition and its use in bone repair
US5073373A (en) 1989-09-21 1991-12-17 Osteotech, Inc. Flowable demineralized bone powder composition and its use in bone repair
US5443832A (en) 1990-04-16 1995-08-22 Institut Swisse De Recherches Experimentales Sur Le Cancer Hydroxyapatite-antigen conjugates and methods for generating a poly-Ig immune response
ATE209251T1 (en) 1990-05-16 2001-12-15 Genetics Inst PROTEINS PRODUCING BONE AND CARTILAGE FORMATION
US5462751A (en) 1990-06-22 1995-10-31 The Regeants Of The University Of California Biological and pharmaceutical agents having a nanomeric biodegradable core
JP2621622B2 (en) 1990-09-27 1997-06-18 三菱マテリアル株式会社 Hydraulic calcium phosphate cement
US5226914A (en) 1990-11-16 1993-07-13 Caplan Arnold I Method for treating connective tissue disorders
US5197985A (en) 1990-11-16 1993-03-30 Caplan Arnold I Method for enhancing the implantation and differentiation of marrow-derived mesenchymal cells
US5486359A (en) 1990-11-16 1996-01-23 Osiris Therapeutics, Inc. Human mesenchymal stem cells
US5149368A (en) 1991-01-10 1992-09-22 Liu Sung Tsuen Resorbable bioactive calcium phosphate cement
US5262166A (en) 1991-04-17 1993-11-16 Lty Medical Inc Resorbable bioactive phosphate containing cements
KR100255415B1 (en) 1991-06-25 2000-05-01 브루스 엠. 에이센 Bone morphogenetic protein-9 compositions
DE69205736T2 (en) 1991-06-26 1996-06-13 Nitta Gelatin Kk Hardenable calcium phosphate-containing material for repairing living hard tissues.
US5782971B1 (en) 1991-06-28 1999-09-21 Norian Corp Calcium phosphate cements comprising amorophous calcium phosphate
JP2686684B2 (en) 1991-08-27 1997-12-08 寅雄 大塚 Tube mesh knitted with hydroxyapatite and knitted with biosoluble fibers
ATE238417T1 (en) 1991-11-04 2003-05-15 Inst Genetics Llc RECOMBINANT BONE MORPHOGENETIC PROTEIN HETERODIMERS, COMPOSITIONS AND METHODS OF USE
US5605713A (en) 1991-11-22 1997-02-25 Boltong; Maria G. Process for the preparation of calcium phosphate cements and its application as bio-materials
US5258044A (en) 1992-01-30 1993-11-02 Etex Corporation Electrophoretic deposition of calcium phosphate material on implants
US5306305A (en) 1992-01-31 1994-04-26 Etex Corporation Methods of coating implants with bony structure
US5281265A (en) 1992-02-03 1994-01-25 Liu Sung Tsuen Resorbable surgical cements
US5314476A (en) 1992-02-04 1994-05-24 Osteotech, Inc. Demineralized bone particles and flowable osteogenic composition containing same
HU218845B (en) 1992-02-12 2000-12-28 Biopharm Gesellschaft Zur Biotechnologischen Entwicklung Von Pharmaka Mbh. Dna sequences encoding novel growth/differentiation factors, pharmaceutical preparations containing said factors, dna molecules, mosts, antibodies and diagnostic methods
ES2167330T3 (en) 1992-02-28 2002-05-16 Cohesion Tech Inc INJECTABLE CERAMIC COMPOSITIONS AND ITS PREPARATION AND USE PROCEDURE.
IL106278A0 (en) 1992-07-13 1993-11-15 Sumitomo Metal Ind Bone formation-inducing protein
ES2149823T3 (en) 1992-09-03 2000-11-16 Univ California FACTOR AND COMPOSITIONS THAT AFFECT THE DORSAL TISSUE.
US5399665A (en) 1992-11-05 1995-03-21 Massachusetts Institute Of Technology Biodegradable polymers for cell transplantation
EP1439190A1 (en) 1993-01-12 2004-07-21 The Johns Hopkins University School Of Medicine Growth differentiation factor-5
WO1994015966A1 (en) 1993-01-12 1994-07-21 Johns Hopkins University School Of Medicine Growth differentiation factor-9
JPH08505771A (en) 1993-01-12 1996-06-25 ジョーンズ ホプキンス ユニバーシティー スクール オブ メディシン Growth differentiation factor-3
US5514378A (en) 1993-02-01 1996-05-07 Massachusetts Institute Of Technology Biocompatible polymer membranes and methods of preparation of three dimensional membrane structures
US5522893A (en) 1993-03-12 1996-06-04 American Dental Association Health Foundation Calcium phosphate hydroxyapatite precursor and methods for making and using the same
JPH09507829A (en) 1993-03-19 1997-08-12 ジョーンズ ホプキンス ユニバーシティー スクール オブ メディシン Growth differentiation factor-8
US5565502A (en) 1993-03-24 1996-10-15 Children's Medical Center Corporation Isolation of the calcium-phosphate crystals of bone
WO1994025637A1 (en) 1993-04-23 1994-11-10 Etex Corporation Method of coating medical devices and devices coated thereby
KR100231640B1 (en) 1993-05-12 1999-12-01 토마스 제이 데스로저 Bmp-10 compositions
EP2272959A1 (en) 1993-05-12 2011-01-12 Genetics Institute, LLC BMP-11 compositions
GB9310321D0 (en) 1993-05-19 1993-06-30 Queen Mary & Westfield College Method for the preparation of carbonated hydroxyapatite compositions
WO1995001801A1 (en) 1993-07-09 1995-01-19 The Johns Hopkins University School Of Medicine Growth differentiation factor-6
JPH09503904A (en) 1993-07-09 1997-04-22 ザ ジョーンズ ホプキンス ユニバーシティー スクール オブ メディシン Growth differentiation factor-7
RU2077329C1 (en) 1993-07-21 1997-04-20 Акционерное общество закрытого типа "ОСТИМ" Agent for osseous tissue growth stimulation
WO1995003369A1 (en) 1993-07-22 1995-02-02 Norian Corporation Storage stable partially neutralized acid compositions and uses
US5763092A (en) 1993-09-15 1998-06-09 Etex Corporation Hydroxyapatite coatings and a method of their manufacture
US6291206B1 (en) 1993-09-17 2001-09-18 Genetics Institute, Inc. BMP receptor proteins
US5525148A (en) 1993-09-24 1996-06-11 American Dental Association Health Foundation Self-setting calcium phosphate cements and methods for preparing and using them
CA2171546A1 (en) 1993-10-08 1995-04-20 Se-Jin Lee Growth differentiation factor-10
CA2176942C (en) 1993-12-07 2011-11-01 Anthony J. Celeste Bmp-12, bmp-13 and tendon-inducing compositions thereof
WO1995018856A1 (en) 1993-12-30 1995-07-13 President And Fellows Of Harvard College Vertebrate embryonic pattern-inducing hedgehog-like proteins
JPH07250688A (en) 1994-01-28 1995-10-03 Sagami Chem Res Center New human c-dna coding tgf-beta superfamily protein
US5508342A (en) 1994-02-01 1996-04-16 The United States Of America As Represented By The Secretary Of Commerce Polymeric amorphous calcium phosphate compositions
WO1998020939A2 (en) 1996-11-15 1998-05-22 Advanced Bio Surfaces, Inc. Biomaterial system for in situ tissue repair
CA2194660C (en) 1994-07-08 2009-09-29 Se-Jin Lee Growth differentiation factor-11
EP0770089B1 (en) 1994-07-13 2000-09-06 The Johns Hopkins University School Of Medicine Growth differentiation factor-12
US5516532A (en) 1994-08-05 1996-05-14 Children's Medical Center Corporation Injectable non-immunogenic cartilage and bone preparation
US5496399A (en) 1994-08-23 1996-03-05 Norian Corporation Storage stable calcium phosphate cements
US5569442A (en) 1994-11-04 1996-10-29 Norian Corporation Reactive tricalcium phosphate compositions and uses
US6281332B1 (en) 1994-12-02 2001-08-28 The Johns Hopkins University School Of Medicine Hedgehog-derived polypeptides
US5904716A (en) 1995-04-26 1999-05-18 Gendler; El Method for reconstituting cartilage tissue using demineralized bone and product thereof
US5635372A (en) 1995-05-18 1997-06-03 Genetics Institute, Inc. BMP-15 compositions
US6027742A (en) 1995-05-19 2000-02-22 Etex Corporation Bioresorbable ceramic composites
US6541037B1 (en) 1995-05-19 2003-04-01 Etex Corporation Delivery vehicle
US5676976A (en) 1995-05-19 1997-10-14 Etex Corporation Synthesis of reactive amorphous calcium phosphates
US6287341B1 (en) 1995-05-19 2001-09-11 Etex Corporation Orthopedic and dental ceramic implants
US6132463A (en) 1995-05-19 2000-10-17 Etex Corporation Cell seeding of ceramic compositions
US6117456A (en) 1995-05-19 2000-09-12 Etex Corporation Methods and products related to the physical conversion of reactive amorphous calcium phosphate
US5700289A (en) 1995-10-20 1997-12-23 North Shore University Hospital Research Corporation Tissue-engineered bone repair using cultured periosteal cells
US5702717A (en) 1995-10-25 1997-12-30 Macromed, Inc. Thermosensitive biodegradable polymers based on poly(ether-ester)block copolymers
US5783217A (en) 1995-11-07 1998-07-21 Etex Corporation Low temperature calcium phosphate apatite and a method of its manufacture
US6033582A (en) 1996-01-22 2000-03-07 Etex Corporation Surface modification of medical implants
US5843289A (en) 1996-01-22 1998-12-01 Etex Corporation Surface modification of medical implants
US5965403A (en) 1996-09-18 1999-10-12 Genetics Institute, Inc. Nucleic acids encoding bone morphogenic protein-16 (BMP-16)
US6953594B2 (en) 1996-10-10 2005-10-11 Etex Corporation Method of preparing a poorly crystalline calcium phosphate and methods of its use
US5795330A (en) 1996-10-10 1998-08-18 Etex Corporation Mixing device
JP4260891B2 (en) 1996-10-16 2009-04-30 エテックス コーポレイション Bioceramic composition
US20020098222A1 (en) 1997-03-13 2002-07-25 John F. Wironen Bone paste
US6071982A (en) 1997-04-18 2000-06-06 Cambridge Scientific, Inc. Bioerodible polymeric semi-interpenetrating network alloys for surgical plates and bone cements, and method for making same
US20020076429A1 (en) 1998-01-28 2002-06-20 John F. Wironen Bone paste subjected to irradiative and thermal treatment
US6030635A (en) 1998-02-27 2000-02-29 Musculoskeletal Transplant Foundation Malleable paste for filling bone defects
US5968253A (en) 1998-07-31 1999-10-19 Norian Corporation Calcium phosphate cements comprising antimicrobial agents
ATE296643T1 (en) 1999-02-04 2005-06-15 Sdgi Holdings Inc OSTEOGENIC PASTE COMPOSITIONS AND THEIR USE
US6461631B1 (en) 1999-11-16 2002-10-08 Atrix Laboratories, Inc. Biodegradable polymer composition
US6340477B1 (en) 2000-04-27 2002-01-22 Lifenet Bone matrix composition and methods for making and using same
US6599516B1 (en) 2000-09-14 2003-07-29 Etex Corporation Malleable implant containing solid element that resorbs or fractures to provide access channels
US6547866B1 (en) * 2000-10-30 2003-04-15 Howmedica Osteonics Corp. Porous calcium phosphate cement
GB2377285A (en) * 2001-07-02 2003-01-08 Ubinetics Ltd State machine
WO2003057137A2 (en) 2001-12-21 2003-07-17 Etex Corporation Synthesis of calcium phosphates by mechano-chemical process
US6840961B2 (en) 2001-12-21 2005-01-11 Etex Corporation Machinable preformed calcium phosphate bone substitute material implants
US7582309B2 (en) 2002-11-15 2009-09-01 Etex Corporation Cohesive demineralized bone compositions
JP3935122B2 (en) 2003-08-06 2007-06-20 日本航空電子工業株式会社 connector
US7252833B2 (en) 2003-11-18 2007-08-07 Skeletal Kinetics, Llc Calcium phosphate cements comprising an osteoclastogenic agent
US7252841B2 (en) 2004-05-20 2007-08-07 Skeletal Kinetics, Llc Rapid setting calcium phosphate cements
US7175858B2 (en) 2004-07-26 2007-02-13 Skeletal Kinetics Llc Calcium phosphate cements and methods for using the same
US8147860B2 (en) * 2005-12-06 2012-04-03 Etex Corporation Porous calcium phosphate bone material

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020187104A1 (en) * 2001-06-08 2002-12-12 Wyeth Calcuim phosphate delivery vehicles for osteoinductive proteins
US20030180344A1 (en) * 2002-02-05 2003-09-25 Cambridge Scientific, Inc. Bioresorbable osteoconductive compositions for bone regeneration
US20050084542A1 (en) * 2003-04-11 2005-04-21 Rosenberg Aron D. Osteoinductive bone material

Also Published As

Publication number Publication date
EP2992855A1 (en) 2016-03-09
KR20080113013A (en) 2008-12-26
US8147860B2 (en) 2012-04-03
US20120282301A1 (en) 2012-11-08
US8545858B2 (en) 2013-10-01
EP1962716A4 (en) 2010-11-03
KR101395884B1 (en) 2014-05-21
EP1962716A2 (en) 2008-09-03
JP5416972B2 (en) 2014-02-12
WO2007067561A2 (en) 2007-06-14
EP1962716B1 (en) 2015-03-04
CN101420922B (en) 2013-10-16
CA2632785C (en) 2015-02-24
AU2006322025A1 (en) 2007-06-14
EP2992855B1 (en) 2017-11-29
AU2006322025B2 (en) 2013-08-15
JP2009519052A (en) 2009-05-14
US20070128245A1 (en) 2007-06-07
CN101420922A (en) 2009-04-29
CA2632785A1 (en) 2007-06-14

Similar Documents

Publication Publication Date Title
WO2007067561A3 (en) Porous calcium phosphate bone material
ATE285801T1 (en) CALCIUM PHOSPHATE/SULFATE BASED BONE IMPLANT COMPOSITION
RS20080336A (en) Activin-actriia antagonists and uses for promoting bone growth
WO2006084166A3 (en) Surgical implants and related methods and systems
WO2009142770A3 (en) Compositions and methods for generating musculoskeletal tissue
WO2007067726A3 (en) Apparatus and methods for treating bone
WO2008064672A3 (en) Bone implant, and set for the production of bone implants
GB2432845A (en) Gradient scaffolding and methods of producing the same
WO2007028169A3 (en) A method for cell implantation
WO2008109807A3 (en) Bone void filler
WO2004091435A3 (en) Osteoinductive bone material
PL2029184T3 (en) Injectable fibrin composition for bone augmentation
WO2006015127A3 (en) Treating cardiovascular tissue
WO2008003320A3 (en) Three-dimensional cell scaffolds
WO2006127954A3 (en) Dithiocarbamates and phosphite formulations
HK1099324A1 (en) Open-pored polyurethane foam without skin formation, formulation for the production thereof and use thereof as a carrier material for cell and tissue cultures or medicaments
WO2006041884A3 (en) Composition, process and method of use for treating algae and pests
WO2005102281A3 (en) Porous calcium phosphate networks for synthetic bone material
WO2006015275A3 (en) Method for enhancing bone formation
WO2006011061A3 (en) Isolated muscle satellite cells, use thereof in muscle tissue repair and method for isolating said muscle satellite cells
WO2009087148A3 (en) Analgesic apatitic calcium-phosphate cement
MX2007013262A (en) Method of well treatment and construction.
EP1810699A3 (en) Biodegradable hemostatic compositions
WO2005020846A3 (en) Artificial bone and joint compositions and methods of use and manufacture
WO2004028576A3 (en) Adhesive bone cement

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application
WWE Wipo information: entry into national phase

Ref document number: 2008544447

Country of ref document: JP

Ref document number: 2632785

Country of ref document: CA

NENP Non-entry into the national phase

Ref country code: DE

WWE Wipo information: entry into national phase

Ref document number: 2006322025

Country of ref document: AU

WWE Wipo information: entry into national phase

Ref document number: 1020087016283

Country of ref document: KR

WWE Wipo information: entry into national phase

Ref document number: 2006844849

Country of ref document: EP

ENP Entry into the national phase

Ref document number: 2006322025

Country of ref document: AU

Date of ref document: 20061206

Kind code of ref document: A

WWE Wipo information: entry into national phase

Ref document number: 200680052052.7

Country of ref document: CN