WO2005084751A3 - Implantable system for controlling gene expression - Google Patents

Implantable system for controlling gene expression Download PDF

Info

Publication number
WO2005084751A3
WO2005084751A3 PCT/US2005/006069 US2005006069W WO2005084751A3 WO 2005084751 A3 WO2005084751 A3 WO 2005084751A3 US 2005006069 W US2005006069 W US 2005006069W WO 2005084751 A3 WO2005084751 A3 WO 2005084751A3
Authority
WO
WIPO (PCT)
Prior art keywords
gene expression
gene therapy
gene
implantable system
controlling gene
Prior art date
Application number
PCT/US2005/006069
Other languages
French (fr)
Other versions
WO2005084751A2 (en
Inventor
Steven D Girouard
Jeffrey Ross
Original Assignee
Cardiac Pacemakers Inc
Steven D Girouard
Jeffrey Ross
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cardiac Pacemakers Inc, Steven D Girouard, Jeffrey Ross filed Critical Cardiac Pacemakers Inc
Priority to EP05714075A priority Critical patent/EP1729849A2/en
Priority to JP2007501003A priority patent/JP2007531564A/en
Publication of WO2005084751A2 publication Critical patent/WO2005084751A2/en
Publication of WO2005084751A3 publication Critical patent/WO2005084751A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/362—Heart stimulators
    • A61N1/3627—Heart stimulators for treating a mechanical deficiency of the heart, e.g. congestive heart failure or cardiomyopathy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6957—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a device or a kit, e.g. stents or microdevices
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/168—Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters ; Monitoring media flow to the body
    • A61M5/172—Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters ; Monitoring media flow to the body electrical or electronic
    • A61M5/1723—Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters ; Monitoring media flow to the body electrical or electronic using feedback of body parameters, e.g. blood-sugar, pressure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/326—Applying electric currents by contact electrodes alternating or intermittent currents for promoting growth of cells, e.g. bone cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/362—Heart stimulators
    • A61N1/3629—Heart stimulators in combination with non-electric therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/35—Communication
    • A61M2205/3507—Communication with implanted devices, e.g. external control
    • A61M2205/3523—Communication with implanted devices, e.g. external control using telemetric means
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142—Pressure infusion, e.g. using pumps
    • A61M5/14244—Pressure infusion, e.g. using pumps adapted to be carried by the patient, e.g. portable on the body
    • A61M5/14276—Pressure infusion, e.g. using pumps adapted to be carried by the patient, e.g. portable on the body specially adapted for implantation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/362—Heart stimulators
    • A61N1/365—Heart stimulators controlled by a physiological parameter, e.g. heart potential
    • A61N1/36514—Heart stimulators controlled by a physiological parameter, e.g. heart potential controlled by a physiological quantity other than heart potential, e.g. blood pressure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/38—Applying electric currents by contact electrodes alternating or intermittent currents for producing shock effects
    • A61N1/39—Heart defibrillators
    • A61N1/3956—Implantable devices for applying electric shocks to the heart, e.g. for cardioversion
    • A61N1/3962—Implantable devices for applying electric shocks to the heart, e.g. for cardioversion in combination with another heart therapy
    • A61N1/39622—Pacing therapy

Abstract

A gene regulatory system controls gene therapy by emitting one or more forms of energy that regulate gene expression by triggering promoters. The system includes a sensor to sense a signal indicative of a need for the gene therapy as well as responses to the gene therapy. The regulation of the gene expression is controlled based on the sensed signal and/or a user command. In one embodiment, the system delivers one or more electrical therapies in conjunction with the gene therapy.
PCT/US2005/006069 2004-02-27 2005-02-28 Implantable system for controlling gene expression WO2005084751A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
EP05714075A EP1729849A2 (en) 2004-02-27 2005-02-28 Implantable system for controlling gene expression
JP2007501003A JP2007531564A (en) 2004-02-27 2005-02-28 Implantable systems that control gene expression

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10/788,906 US7840263B2 (en) 2004-02-27 2004-02-27 Method and apparatus for device controlled gene expression
US10/788,906 2004-02-27

Publications (2)

Publication Number Publication Date
WO2005084751A2 WO2005084751A2 (en) 2005-09-15
WO2005084751A3 true WO2005084751A3 (en) 2005-12-15

Family

ID=34887123

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2005/006069 WO2005084751A2 (en) 2004-02-27 2005-02-28 Implantable system for controlling gene expression

Country Status (4)

Country Link
US (1) US7840263B2 (en)
EP (1) EP1729849A2 (en)
JP (1) JP2007531564A (en)
WO (1) WO2005084751A2 (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7729761B2 (en) 2004-07-14 2010-06-01 Cardiac Pacemakers, Inc. Method and apparatus for controlled gene or protein delivery
US7764995B2 (en) 2004-06-07 2010-07-27 Cardiac Pacemakers, Inc. Method and apparatus to modulate cellular regeneration post myocardial infarct
US7840263B2 (en) 2004-02-27 2010-11-23 Cardiac Pacemakers, Inc. Method and apparatus for device controlled gene expression

Families Citing this family (92)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0928135B1 (en) * 1996-07-17 2006-06-14 Medtronic, Inc. System for enhancing cardiac signal sensing by cardiac pacemakers through genetic treatment
US20030036746A1 (en) 2001-08-16 2003-02-20 Avi Penner Devices for intrabody delivery of molecules and systems and methods utilizing same
US20050283197A1 (en) * 2001-04-10 2005-12-22 Daum Douglas R Systems and methods for hypotension
US11439815B2 (en) 2003-03-10 2022-09-13 Impulse Dynamics Nv Protein activity modification
US7320675B2 (en) 2003-08-21 2008-01-22 Cardiac Pacemakers, Inc. Method and apparatus for modulating cellular metabolism during post-ischemia or heart failure
US11779768B2 (en) 2004-03-10 2023-10-10 Impulse Dynamics Nv Protein activity modification
US7828711B2 (en) 2004-08-16 2010-11-09 Cardiac Pacemakers, Inc. Method and apparatus for modulating cellular growth and regeneration using ventricular assist device
US7387610B2 (en) 2004-08-19 2008-06-17 Cardiac Pacemakers, Inc. Thoracic impedance detection with blood resistivity compensation
US7621906B2 (en) * 2004-08-25 2009-11-24 Cardiac Pacemakers, Inc. Method and apparatus to deliver drug and pacing therapy for treatment of cardiac disorders
US20060064133A1 (en) 2004-09-17 2006-03-23 Cardiac Pacemakers, Inc. System and method for deriving relative physiologic measurements using an external computing device
US7813808B1 (en) 2004-11-24 2010-10-12 Remon Medical Technologies Ltd Implanted sensor system with optimized operational and sensing parameters
US7981065B2 (en) * 2004-12-20 2011-07-19 Cardiac Pacemakers, Inc. Lead electrode incorporating extracellular matrix
US8874204B2 (en) 2004-12-20 2014-10-28 Cardiac Pacemakers, Inc. Implantable medical devices comprising isolated extracellular matrix
US8060219B2 (en) 2004-12-20 2011-11-15 Cardiac Pacemakers, Inc. Epicardial patch including isolated extracellular matrix with pacing electrodes
US7548780B2 (en) * 2005-02-22 2009-06-16 Cardiac Pacemakers, Inc. Cell therapy and neural stimulation for cardiac repair
JP2008534196A (en) * 2005-04-06 2008-08-28 シャルマー，フリーデリーケ Implantable electromedical or extracorporeally applicable device for organ treatment and organ monitoring and method for therapeutic organ treatment
US20160361559A1 (en) 2007-10-12 2016-12-15 Berlin Heals Holding Ag Electromedical implantable or extracorporeally applicable device for the treatment or monitoring of organs, and method for therapeutic organ treatment
US8892197B2 (en) * 2005-07-29 2014-11-18 Medtronic, Inc. Method and apparatus to control conduction through the heart to treat cardiac conditions
US20070036770A1 (en) * 2005-08-12 2007-02-15 Wagner Darrell O Biologic device for regulation of gene expression and method therefor
US7774057B2 (en) 2005-09-06 2010-08-10 Cardiac Pacemakers, Inc. Method and apparatus for device controlled gene expression for cardiac protection
US7742815B2 (en) * 2005-09-09 2010-06-22 Cardiac Pacemakers, Inc. Using implanted sensors for feedback control of implanted medical devices
US7630761B2 (en) * 2005-11-04 2009-12-08 Cardiac Pacemakers, Inc. Method and apparatus for modifying tissue to improve electrical stimulation efficacy
US8936590B2 (en) * 2005-11-09 2015-01-20 The Invention Science Fund I, Llc Acoustically controlled reaction device
US8992511B2 (en) 2005-11-09 2015-03-31 The Invention Science Fund I, Llc Acoustically controlled substance delivery device
US7817030B2 (en) 2005-11-09 2010-10-19 Invention Science Fund 1, Llc Remote controller for in situ reaction device
US9067047B2 (en) 2005-11-09 2015-06-30 The Invention Science Fund I, Llc Injectable controlled release fluid delivery system
US8998886B2 (en) 2005-12-13 2015-04-07 The Invention Science Fund I, Llc Remote control of osmotic pump device
GB2446096B (en) * 2005-11-09 2012-01-11 Searete Llc Accoustically controlled reaction device
US7942867B2 (en) 2005-11-09 2011-05-17 The Invention Science Fund I, Llc Remotely controlled substance delivery device
US8083710B2 (en) * 2006-03-09 2011-12-27 The Invention Science Fund I, Llc Acoustically controlled substance delivery device
US8273071B2 (en) * 2006-01-18 2012-09-25 The Invention Science Fund I, Llc Remote controller for substance delivery system
US7848823B2 (en) 2005-12-09 2010-12-07 Boston Scientific Scimed, Inc. Cardiac stimulation system
US8050774B2 (en) 2005-12-22 2011-11-01 Boston Scientific Scimed, Inc. Electrode apparatus, systems and methods
US20070190028A1 (en) * 2006-02-13 2007-08-16 Jihong Qu Method and apparatus for heat or electromagnetic control of gene expression
US20080140057A1 (en) 2006-03-09 2008-06-12 Searete Llc, A Limited Liability Corporation Of State Of The Delaware Injectable controlled release fluid delivery system
US7688835B2 (en) * 2006-03-15 2010-03-30 Motorola, Inc. Dynamic wireless backhaul
US20070218910A1 (en) * 2006-03-15 2007-09-20 Motorola, Inc. Dynamic beam steering of backhaul traffic
US7937161B2 (en) 2006-03-31 2011-05-03 Boston Scientific Scimed, Inc. Cardiac stimulation electrodes, delivery devices, and implantation configurations
US8005543B2 (en) 2006-05-08 2011-08-23 Cardiac Pacemakers, Inc. Heart failure management system
US7840281B2 (en) 2006-07-21 2010-11-23 Boston Scientific Scimed, Inc. Delivery of cardiac stimulation devices
US7955268B2 (en) 2006-07-21 2011-06-07 Cardiac Pacemakers, Inc. Multiple sensor deployment
EP2044199B1 (en) * 2006-07-25 2012-11-14 Celladon Corporation Extended antegrade epicardial coronary infusion of adeno-associated viral vectors comprising serca2a for gene therapy
US20080076836A1 (en) * 2006-09-01 2008-03-27 Cardiac Pacemakers, Inc Method and apparatus for using light to enhance cell growth and survival
US20080058905A1 (en) * 2006-09-01 2008-03-06 Wagner Darrell O Method and apparatus utilizing light as therapy for fungal infection
US20080058881A1 (en) * 2006-09-01 2008-03-06 Cardiac Pacemakers, Inc Method and system for treating post-mi patients
US20080081354A1 (en) * 2006-10-02 2008-04-03 Cardiac Pacemakers, Inc. Devices, vectors and methods for inducible ischemia cardioprotection
US9220837B2 (en) 2007-03-19 2015-12-29 Insuline Medical Ltd. Method and device for drug delivery
US8622991B2 (en) 2007-03-19 2014-01-07 Insuline Medical Ltd. Method and device for drug delivery
WO2009081262A1 (en) 2007-12-18 2009-07-02 Insuline Medical Ltd. Drug delivery device with sensor for closed-loop operation
KR20090128499A (en) 2007-03-19 2009-12-15 인슐린 메디컬 엘티디 Drug delivery device
US7844333B1 (en) * 2007-04-17 2010-11-30 Pacesetter, Inc. Pacing therapy for transient ischemia treatment
US9150832B2 (en) * 2007-05-08 2015-10-06 Cardiac Pacemakers, Inc. Cell training for local field stimulation
US8224443B2 (en) * 2007-05-08 2012-07-17 Cardiac Pacemakers, Inc. Method for controlling pacemaker therapy
US20080280341A1 (en) * 2007-05-08 2008-11-13 Kenknight Bruce System And Method For Local Field Stimulation
US8442631B2 (en) 2007-05-08 2013-05-14 Cardiac Pacemakers, Inc. System and method for determining the origin of a sensed beat
US20090054828A1 (en) * 2007-08-22 2009-02-26 Cardiac Pacemakers, Inc. Systems for transient conduction control
US8311620B2 (en) * 2007-08-22 2012-11-13 Cardiac Pacemakers, Inc. Methods and apparatus to treat and prevent atrial tachyarrhythmias
US9066742B2 (en) 2007-11-09 2015-06-30 The Spectranetics Corporation Intra-vascular device with pressure detection capabilities using pressure sensitive material
JP5211177B2 (en) 2008-02-11 2013-06-12 カーディアック ペースメイカーズ， インコーポレイテッド Hemodynamic monitoring method for rhythm discrimination in the heart
WO2009102640A1 (en) 2008-02-12 2009-08-20 Cardiac Pacemakers, Inc. Systems and methods for controlling wireless signal transfers between ultrasound-enabled medical devices
CA2715765A1 (en) 2008-02-19 2009-08-27 Celladon Corporation Compositions for enhanced uptake of viral vectors in the myocardium
US9421065B2 (en) 2008-04-02 2016-08-23 The Spectranetics Corporation Liquid light-guide catheter with optically diverging tip
US8979828B2 (en) 2008-07-21 2015-03-17 The Spectranetics Corporation Tapered liquid light guide
EP2334230A1 (en) 2008-10-10 2011-06-22 Cardiac Pacemakers, Inc. Systems and methods for determining cardiac output using pulmonary artery pressure measurements
CN102245137A (en) 2008-11-07 2011-11-16 茵苏莱恩医药有限公司 Device and method for drug delivery
WO2010059291A1 (en) 2008-11-19 2010-05-27 Cardiac Pacemakers, Inc. Assessment of pulmonary vascular resistance via pulmonary artery pressure
US20110144028A1 (en) * 2009-12-11 2011-06-16 Vinod Sharma Modulating cellular electrophysiology
US8753340B2 (en) * 2012-03-01 2014-06-17 Mark D Noar Catheter structure and method for locating tissue in a body organ and simultaneously delivering therapy and evaluating the therapy delivered
US8761717B1 (en) 2012-08-07 2014-06-24 Brian K. Buchheit Safety feature to disable an electronic device when a wireless implantable medical device (IMD) is proximate
US10589120B1 (en) 2012-12-31 2020-03-17 Gary John Bellinger High-intensity laser therapy method and apparatus
EP2968929B1 (en) * 2013-03-14 2018-10-10 The University of North Carolina at Chapel Hill Device and system for managing acute and chronic pain
KR102624370B1 (en) 2014-03-21 2024-01-15 유니버시티 오브 피츠버그 - 오브 더 커먼웰쓰 시스템 오브 하이어 에듀케이션 Methods for preparation of a terminally sterilized hydrogel derived from extracellular matrix
US10835134B2 (en) * 2014-06-13 2020-11-17 Palo Alto Investors Methods and compositions for restoring homeostatic capacity of a subject
US20170246470A1 (en) 2014-09-24 2017-08-31 The General Hospital Corporation Dba Massachusetts General Hospital Systems and methods for enhancing platelet biogenesis and extending platelet lifespan with low level light
US9750923B2 (en) * 2014-11-19 2017-09-05 Velóce Corporation Wireless communications system integrating electronics into orally ingestible products for controlled release of active ingredients
US9744239B2 (en) 2015-01-30 2017-08-29 Par Pharmaceutical, Inc. Vasopressin formulations for use in treatment of hypotension
US9750785B2 (en) 2015-01-30 2017-09-05 Par Pharmaceutical, Inc. Vasopressin formulations for use in treatment of hypotension
US9687526B2 (en) 2015-01-30 2017-06-27 Par Pharmaceutical, Inc. Vasopressin formulations for use in treatment of hypotension
US9744209B2 (en) 2015-01-30 2017-08-29 Par Pharmaceutical, Inc. Vasopressin formulations for use in treatment of hypotension
US9925233B2 (en) 2015-01-30 2018-03-27 Par Pharmaceutical, Inc. Vasopressin formulations for use in treatment of hypotension
US9937223B2 (en) 2015-01-30 2018-04-10 Par Pharmaceutical, Inc. Vasopressin formulations for use in treatment of hypotension
US10631781B2 (en) 2015-03-05 2020-04-28 Palo Alto Investors Homeostatic capacity evaluation
US11045140B2 (en) 2015-03-05 2021-06-29 Palo Alto Investors Homeostatic capacity evaluation
US20170150922A1 (en) 2015-11-30 2017-06-01 Palo Alto Investors Methods of Enhancing Homeostatic Capacity in a Subject by Increasing Homeostatic System Component Responsiveness, and Devices for Use in Practicing the Same
US11020051B2 (en) 2015-11-30 2021-06-01 Palo Alto Investors Methods of enhancing homeostatic capacity in a subject by modulating homeostatic system synchrony, and devices for use in practicing the same
US11406736B2 (en) 2016-01-13 2022-08-09 University of Pittsburgh—Of the Commonwealth Systems of Higher Education Vascular extracellular matrix hydrogel
US11382513B2 (en) 2016-11-08 2022-07-12 Palo Alto Investors Methods and compositions for treating a condition in a subject
CN112292178A (en) * 2018-06-14 2021-01-29 美敦力公司 Delivery of cardiac pacing therapy for cardiac remodeling
US10918869B2 (en) * 2018-06-15 2021-02-16 Pacesetter, Inc. Methods and systems that monitor and respond to changes in physiological status based on measurements of respiration characteristics and pulmonary arterial pressure obtained from implantable sensors
IL296662A (en) 2020-03-24 2022-11-01 Generation Bio Co Non-viral dna vectors and uses thereof for expressing gaucher therapeutics
KR20230003477A (en) 2020-03-24 2023-01-06 제너레이션 바이오 컴퍼니 Non-viral DNA vectors and their use for expressing Factor IX therapeutics
WO2024040222A1 (en) 2022-08-19 2024-02-22 Generation Bio Co. Cleavable closed-ended dna (cedna) and methods of use thereof

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998002150A1 (en) * 1996-07-17 1998-01-22 Medtronic, Inc. System for genetically treating cardiac conduction disturbances
WO1999025385A1 (en) * 1997-11-17 1999-05-27 Imarx Pharmaceutical Corp. A method of increasing nucleic acid synthesis with ultrasound
US20020049154A1 (en) * 1996-08-27 2002-04-25 University Of Utah Research Foundation Bioconjugates and delivery of bioactive agents
US20020072785A1 (en) * 1999-12-14 2002-06-13 Medtronic, Inc. Apparatus and method for remote therapy and diagnosis in medical devices via interface systems
US20030040777A1 (en) * 1996-01-08 2003-02-27 Itzik Shemer Modulation of intracellular calcium concentration using non-excitatory electrical signals applied to the tissue
US20030204206A1 (en) * 2000-12-21 2003-10-30 Medtronic, Inc. Electrically responsive promoter system
WO2004080533A1 (en) * 2003-03-10 2004-09-23 Impulse Dynamics Nv Apparatus and method for delivering electrical signals to modify gene expression in cardiac tissue
WO2004093969A1 (en) * 2003-04-23 2004-11-04 Medtronic, Inc. System for the delivery of a biologic therapy with device monitoring and back-up

Family Cites Families (350)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3692027A (en) 1971-04-23 1972-09-19 Everett H Ellinwood Jr Implanted medication dispensing device and method
US4003379A (en) 1974-04-23 1977-01-18 Ellinwood Jr Everett H Apparatus and method for implanted self-powered medication dispensing
US4146029A (en) 1974-04-23 1979-03-27 Ellinwood Jr Everett H Self-powered implanted programmable medication system and method
US4299220A (en) 1979-05-03 1981-11-10 The Regents Of The University Of Minnesota Implantable drug infusion regulator
US4281664A (en) 1979-05-14 1981-08-04 Medtronic, Inc. Implantable telemetry transmission system for analog and digital data
US4556063A (en) 1980-10-07 1985-12-03 Medtronic, Inc. Telemetry system for a medical device
DE3046802A1 (en) 1980-12-12 1982-07-15 Basf Ag, 6700 Ludwigshafen ETHYLENE-ALKINE COPOLYMERISATES, THEIR PRODUCTION AND USE AS AN ADDITION TO PETROLEUM DISTILLATES
US4686987A (en) 1981-06-18 1987-08-18 Cardiac Pacemakers, Inc. Biomedical method and apparatus for controlling the administration of therapy to a patient in response to changes in physiologic demand
US5190035A (en) 1981-06-18 1993-03-02 Cardiac Pacemakers, Inc. Biomedical method and apparatus for controlling the administration of therapy to a patient in response to changes in physiological demand
US4544371A (en) 1982-10-05 1985-10-01 American Hospital Supply Corporation Implantable metered dose drug delivery system
CA1254091A (en) 1984-09-28 1989-05-16 Vladimir Feingold Implantable medication infusion system
US4938231A (en) 1985-10-22 1990-07-03 Telectronics N.V. Defibrillator electrode
US4677989A (en) 1986-02-06 1987-07-07 Eic Laboratories, Inc. Iridium oxide coated electrodes for neural stimulation
US5269301A (en) 1987-10-06 1993-12-14 Leonard Bloom Multimode system for monitoring and treating a malfunctioning heart
US5014698A (en) 1987-10-06 1991-05-14 Leonard Bloom Method of and system for monitoring and treating a malfunctioning heart
US4924875A (en) 1987-10-09 1990-05-15 Biometrak Corporation Cardiac biopotential analysis system and method
US5259380A (en) 1987-11-04 1993-11-09 Amcor Electronics, Ltd. Light therapy system
US5108363A (en) 1988-02-19 1992-04-28 Gensia Pharmaceuticals, Inc. Diagnosis, evaluation and treatment of coronary artery disease by exercise simulation using closed loop drug delivery of an exercise simulating agent beta agonist
US5387419A (en) 1988-03-31 1995-02-07 The University Of Michigan System for controlled release of antiarrhythmic agents
US5130141A (en) 1988-05-24 1992-07-14 Law Peter K Compositions for and methods of treating muscle degeneration and weakness
CA1327838C (en) 1988-06-13 1994-03-15 Fred Zacouto Implantable device to prevent blood clotting disorders
IT1217836B (en) 1988-06-17 1990-03-30 Pierluigi Spalla SELF-PROPELLED AND MULTI-PURPOSE AGRICULTURAL MACHINE
US4902508A (en) 1988-07-11 1990-02-20 Purdue Research Foundation Tissue graft composition
US5025786A (en) 1988-07-21 1991-06-25 Siegel Sharon B Intracardiac catheter and method for detecting and diagnosing myocardial ischemia
US5103821A (en) 1989-03-06 1992-04-14 Angeion Corporation Method of providing a biological pacemaker
US5538722A (en) 1989-06-13 1996-07-23 Stanford University Isolation, growth, differentiation and genetic engineering of human muscle cells
US5374241A (en) 1989-07-21 1994-12-20 Iomed, Inc. Electrodes for iontophoresis
US4944299A (en) 1989-08-08 1990-07-31 Siemens-Pacesetter, Inc. High speed digital telemetry system for implantable device
US5101814A (en) 1989-08-11 1992-04-07 Palti Yoram Prof System for monitoring and controlling blood glucose
US4987897A (en) 1989-09-18 1991-01-29 Medtronic, Inc. Body bus medical device communication system
US5041107A (en) 1989-10-06 1991-08-20 Cardiac Pacemakers, Inc. Electrically controllable, non-occluding, body implantable drug delivery system
AU624284B2 (en) 1989-11-24 1992-06-04 Monash University Proliferative action of leukaemia inhibitory factor on satellite cells
IT1251509B (en) 1989-11-24 1995-05-16 Leonardo Cammilli IMPLANTABLE DEFIBRILLATOR WITH AUTOMATIC RECOGNITION OF VENTRICULAR FIBRILLATION, WITH PHARMACOLOGICAL ACTION
US5031621A (en) 1989-12-06 1991-07-16 Grandjean Pierre A Nerve electrode with biological substrate
JPH03189456A (en) 1989-12-18 1991-08-19 Mazda Motor Corp Speed change control device for continuously variable transmission
US5040533A (en) 1989-12-29 1991-08-20 Medical Engineering And Development Institute Incorporated Implantable cardiovascular treatment device container for sensing a physiological parameter
US5127404A (en) 1990-01-22 1992-07-07 Medtronic, Inc. Telemetry format for implanted medical device
US5042497A (en) 1990-01-30 1991-08-27 Cardiac Pacemakers, Inc. Arrhythmia prediction and prevention for implanted devices
US5058581A (en) 1990-02-20 1991-10-22 Siemens-Pacesetter, Inc. Telemetry apparatus and method for implantable tissue stimulator
US5284136A (en) 1990-04-04 1994-02-08 Cardiac Pacemakers, Inc. Dual indifferent electrode pacemaker
US5499971A (en) 1990-06-15 1996-03-19 Cortrak Medical, Inc. Method for iontophoretically delivering drug adjacent to a heart
US5087243A (en) 1990-06-18 1992-02-11 Boaz Avitall Myocardial iontophoresis
JPH04250169A (en) 1990-07-20 1992-09-07 Telectronics Nv Patient treating apparatus and method
US5109842A (en) 1990-09-24 1992-05-05 Siemens Pacesetter, Inc. Implantable tachyarrhythmia control system having a patch electrode with an integrated cardiac activity system
US5486359A (en) 1990-11-16 1996-01-23 Osiris Therapeutics, Inc. Human mesenchymal stem cells
US5179947A (en) 1991-01-15 1993-01-19 Cardiac Pacemakers, Inc. Acceleration-sensitive cardiac pacemaker and method of operation
US5605938A (en) 1991-05-31 1997-02-25 Gliatech, Inc. Methods and compositions for inhibition of cell invasion and fibrosis using dextran sulfate
US5543318A (en) 1991-06-12 1996-08-06 Smith; David A. Method of isolation, culture and proliferation of human atrial myocytes
CA2111347A1 (en) 1991-06-12 1992-12-23 David A. Smith Method for inducing human myocardial cell proliferation
US5239113A (en) 1991-10-15 1993-08-24 Monsanto Company Substituted β-amino acid derivatives useful as platelet aggregation inhibitors and intermediates thereof
DE69231073T2 (en) 1991-10-24 2001-02-15 Insutech Inc INFUSION SYSTEM DRIVEN BY GAS PRESSURE GENERATED BY HYDROGEL BY ELECTROLYSIS
US5661133B1 (en) 1991-11-12 1999-06-01 Univ Michigan Collateral blood vessel formation in cardiac muscle by injecting a dna sequence encoding an angiogenic protein
CA2082001A1 (en) 1991-11-29 1993-05-30 John C. Potocki Method of screening pacemaker patients for myocardial ischemia
US5251621A (en) 1991-12-18 1993-10-12 Telectronics Pacing Systems, Inc. Arrhythmia control pacer using skeletal muscle cardiac graft stimulation
WO1993021347A1 (en) 1992-04-10 1993-10-28 Fox Chase Cancer Center Transcription control element for increasing gene expression in myoblasts
US5312453A (en) * 1992-05-11 1994-05-17 Medtronic, Inc. Rate responsive cardiac pacemaker and method for work-modulating pacing rate deceleration
US6132419A (en) 1992-05-22 2000-10-17 Genetronics, Inc. Electroporetic gene and drug therapy
US5336252A (en) 1992-06-22 1994-08-09 Cohen Donald M System and method for implanting cardiac electrical leads
US5507724A (en) 1992-07-01 1996-04-16 Genetronics, Inc. Electroporation and iontophoresis apparatus and method for insertion of drugs and genes into cells
US5634899A (en) 1993-08-20 1997-06-03 Cortrak Medical, Inc. Simultaneous cardiac pacing and local drug delivery method
US5807306A (en) 1992-11-09 1998-09-15 Cortrak Medical, Inc. Polymer matrix drug delivery apparatus
US5275826A (en) 1992-11-13 1994-01-04 Purdue Research Foundation Fluidized intestinal submucosa and its use as an injectable tissue graft
US6653291B1 (en) 1992-11-13 2003-11-25 Purdue Research Foundation Composition and method for production of transformed cells
US5352463A (en) 1992-11-13 1994-10-04 Badylak Steven F Tissue graft for surgical reconstruction of a collagenous meniscus and method therefor
EP0668913B1 (en) 1992-11-18 2002-01-30 Arch Development Corporation Adenovirus-mediated gene transfer to cardiac and vascular smooth muscle
US5496362A (en) 1992-11-24 1996-03-05 Cardiac Pacemakers, Inc. Implantable conformal coil patch electrode with multiple conductive elements for cardioversion and defibrillation
US5353800A (en) 1992-12-11 1994-10-11 Medtronic, Inc. Implantable pressure sensor lead
US5342408A (en) 1993-01-07 1994-08-30 Incontrol, Inc. Telemetry system for an implantable cardiac device
US5347241A (en) 1993-02-08 1994-09-13 Hughes Aircraft Company Dual junction back-to-back microstrip four-port circulators
US5416695A (en) 1993-03-09 1995-05-16 Metriplex, Inc. Method and apparatus for alerting patients and medical personnel of emergency medical situations
US20040071637A1 (en) 1993-04-27 2004-04-15 Elia James P. Method for repairing a damaged portion of a human organ
US5404877A (en) 1993-06-04 1995-04-11 Telectronics Pacing Systems, Inc. Leadless implantable sensor assembly and a cardiac emergency warning alarm
US5314430A (en) * 1993-06-24 1994-05-24 Medtronic, Inc. Atrial defibrillator employing transvenous and subcutaneous electrodes and method of use
US5423883A (en) 1993-07-14 1995-06-13 Pacesetter, Inc. Implantable myocardial stimulation lead with sensors thereon
US5738096A (en) 1993-07-20 1998-04-14 Biosense, Inc. Cardiac electromechanics
US5579264A (en) 1993-07-26 1996-11-26 Texas Instruments Incorporated Distributed signal drivers in arrayable devices
US5456692A (en) 1993-09-03 1995-10-10 Pacesetter, Inc. System and method for noninvasively altering the function of an implanted pacemaker
IT1260692B (en) 1993-10-05 1996-04-22 Sorin Biomedica Spa DEVICE FOR DETERMINING THE MYOCARDIC FUNCTION AND ITS PROCEDURE.
US5602301A (en) 1993-11-16 1997-02-11 Indiana University Foundation Non-human mammal having a graft and methods of delivering protein to myocardial tissue
US5527358A (en) 1994-01-21 1996-06-18 Medtronic, Inc. Temporary medical electrical lead
US5409009A (en) 1994-03-18 1995-04-25 Medtronic, Inc. Methods for measurement of arterial blood flow
DE4410423A1 (en) 1994-03-25 1995-09-28 Hoechst Ag Sulfonamidocarbonylpyridin-2-carboxamides and their pyridine N-oxides, processes for their preparation and their use as medicaments
US5496360A (en) 1994-04-12 1996-03-05 Ventritex, Inc. Implantable cardiac electrode with rate controlled drug delivery
US5509924A (en) 1994-04-12 1996-04-23 Ventritex, Inc. Epicardial stimulation electrode with energy directing capability
US6436908B1 (en) 1995-05-30 2002-08-20 Duke University Use of exogenous β-adrenergic receptor and β-adrenergic receptor kinase gene constructs to enhance myocardial function
US6475232B1 (en) 1996-12-10 2002-11-05 Purdue Research Foundation Stent with reduced thrombogenicity
US5925066A (en) 1995-10-26 1999-07-20 Galvani, Ltd. Atrial arrythmia sensor with drug and electrical therapy control apparatus
US5834029A (en) 1994-07-20 1998-11-10 Cytotherapeutics, Inc. Nerve guidance channel containing bioartificial three-dimensional hydrogel extracellular matrix derivatized with cell adhesive peptide fragment
US5831008A (en) 1994-08-18 1998-11-03 La Jolla Cancer Research Foundation Retinoblastoma protein-interacting zinc finger proteins
DE4436967C2 (en) 1994-10-15 2000-04-20 Krupp Bilstein Gmbh Shock absorber lock
US5571151A (en) 1994-10-25 1996-11-05 Gregory; Kenton W. Method for contemporaneous application of laser energy and localized pharmacologic therapy
US5551953A (en) 1994-10-31 1996-09-03 Alza Corporation Electrotransport system with remote telemetry link
DE69529572T2 (en) 1994-11-10 2003-06-18 Univ Kentucky Res Foundation L IMPLANTABLE REFILLABLE DEVICE WITH CONTROLLED RELEASE FOR ADMINISTERING MEDICINAL SUBSTANCES DIRECTLY ON AN INNER PART OF THE BODY
DE4441327C1 (en) 1994-11-22 1995-11-09 Inst Pflanzengenetik & Kultur Embryonic heart muscle cells, their production and their use
SG99846A1 (en) 1994-12-13 2003-11-27 Peter K Law Methods for producing cardiomyocytes capable of proliferation
US5562713A (en) 1995-01-18 1996-10-08 Pacesetter, Inc. Bidirectional telemetry apparatus and method for implantable device
US5741319A (en) 1995-01-27 1998-04-21 Medtronic, Inc. Biocompatible medical lead
US5556421A (en) 1995-02-22 1996-09-17 Intermedics, Inc. Implantable medical device with enclosed physiological parameter sensors or telemetry link
CN1136920C (en) 1995-02-28 2004-02-04 加利福尼亚大学董事会 Gene transfer-mediated angiogenesis therapy
US20030148968A1 (en) 1995-02-28 2003-08-07 Hammond H. Kirk Techniques and compositions for treating cardiovascular disease by in vivo gene delivery
US6306830B1 (en) 1996-09-05 2001-10-23 The Regents Of The University Of California Gene therapy for congestive heart failure
US5833978A (en) 1995-03-16 1998-11-10 Universite Laval Method of in vitro preconditioning healthy donor's myoblasts before transplantation thereof in compatible patients suffering of recessive myopathies like muscular dystrophy, for improving transplantation success
US5554389A (en) 1995-04-07 1996-09-10 Purdue Research Foundation Urinary bladder submucosa derived tissue graft
DE19520940C2 (en) 1995-06-02 1997-07-17 Siemens Ag Arrangement for the galvanically isolated transmission of auxiliary energy (DC voltage) and information to an electronic unit
US5586556A (en) 1995-05-11 1996-12-24 T Z Medical, Inc. Pacemaker and heart monitoring and data transmitting device and method
US5855610A (en) 1995-05-19 1999-01-05 Children's Medical Center Corporation Engineering of strong, pliable tissues
US5609629A (en) 1995-06-07 1997-03-11 Med Institute, Inc. Coated implantable medical device
AU716005B2 (en) 1995-06-07 2000-02-17 Cook Medical Technologies Llc Implantable medical device
US7611533B2 (en) 1995-06-07 2009-11-03 Cook Incorporated Coated implantable medical device
US5800498A (en) 1996-04-26 1998-09-01 Pharmatarget, Inc. Catheter for implantable rhythm control device
US5607418A (en) 1995-08-22 1997-03-04 Illinois Institute Of Technology Implantable drug delivery apparatus
US5662689A (en) 1995-09-08 1997-09-02 Medtronic, Inc. Method and apparatus for alleviating cardioversion shock pain
WO1997012989A1 (en) 1995-10-02 1997-04-10 Katoot Mohammad W Biologically-active polymers
US5720770A (en) 1995-10-06 1998-02-24 Pacesetter, Inc. Cardiac stimulation system with enhanced communication and control capability
WO1997017426A1 (en) 1995-11-08 1997-05-15 Trustees Of Boston University Cellular physiology workstations for automated data acquisition and perfusion control
US5944659A (en) 1995-11-13 1999-08-31 Vitalcom Inc. Architecture for TDMA medical telemetry system
US5858351A (en) 1996-01-18 1999-01-12 Avigen, Inc. Methods for delivering DNA to muscle cells using recombinant adeno-associated virus vectors
US5603331A (en) 1996-02-12 1997-02-18 Cardiac Pacemakers, Inc. Data logging system for implantable cardiac device
US5833603A (en) 1996-03-13 1998-11-10 Lipomatrix, Inc. Implantable biosensing transponder
US6628987B1 (en) 2000-09-26 2003-09-30 Medtronic, Inc. Method and system for sensing cardiac contractions during vagal stimulation-induced cardiopalegia
US6735471B2 (en) 1996-04-30 2004-05-11 Medtronic, Inc. Method and system for endotracheal/esophageal stimulation prior to and during a medical procedure
US5899928A (en) 1996-05-14 1999-05-04 Pacesetter, Inc. Descriptive transtelephonic pacing intervals for use by an emplantable pacemaker
US5690682A (en) 1996-06-17 1997-11-25 Pharmatarget, Inc. Device and method for treatment of cardiac arrhythmia
US5944710A (en) 1996-06-24 1999-08-31 Genetronics, Inc. Electroporation-mediated intravascular delivery
EP0928135B1 (en) 1996-07-17 2006-06-14 Medtronic, Inc. System for enhancing cardiac signal sensing by cardiac pacemakers through genetic treatment
JP2001501458A (en) 1996-08-15 2001-02-06 アメリカ合衆国 Spatial and temporal control of gene expression using a combination of heat shock protein promoter and local heating
US5885797A (en) 1996-08-27 1999-03-23 Fred Hutchinson Cancer Research Center Polynucleotide sequences encoding proteins involved in myogenesis
WO1998014606A1 (en) 1996-10-04 1998-04-09 South Alabama Medical Science Foundation Method for diminishing myocardial infarction using protein phosphatase inhibitors
US5704908A (en) 1996-10-10 1998-01-06 Genetronics, Inc. Electroporation and iontophoresis catheter with porous balloon
AU4981797A (en) 1996-10-11 1998-05-11 Government Of The United States Of America, The Isolation and method of using tissue growth-inducing frzb protein
DE69737460T2 (en) 1996-10-18 2008-04-10 UNIVERSITé LAVAL METHOD FOR THE IN VITRO PRE-TREATMENT OF MOBILATS IN TRANSPLANTATION
JP4676580B2 (en) 1996-11-05 2011-04-27 パーデュー・リサーチ・ファウンデーション Myocardial graft composition
US6059726A (en) 1996-11-08 2000-05-09 The Regents Of The University Of California Method for locating the atrio-ventricular (AV) junction of the heart and injecting active substances therein
US6198394B1 (en) 1996-12-05 2001-03-06 Stephen C. Jacobsen System for remote monitoring of personnel
US5945577A (en) 1997-01-10 1999-08-31 University Of Massachusetts As Represented By Its Amherst Campus Cloning using donor nuclei from proliferating somatic cells
ATE218854T1 (en) 1997-01-31 2002-06-15 Univ Leland Stanford Junior TREATMENT OF CARDIAC ARTHRY DISORDERS BY INHIBITING A MULTIFUNCTIONAL CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASE
US6443949B2 (en) 1997-03-13 2002-09-03 Biocardia, Inc. Method of drug delivery to interstitial regions of the myocardium
US6511477B2 (en) 1997-03-13 2003-01-28 Biocardia, Inc. Method of drug delivery to interstitial regions of the myocardium
US6005009A (en) 1997-03-19 1999-12-21 Duke University Method of inhibiting fibrosis with pyridoxal benzoyl hydrazone and analogs thereof
US6331406B1 (en) 1997-03-31 2001-12-18 The John Hopkins University School Of Medicine Human enbryonic germ cell and methods of use
US6090622A (en) 1997-03-31 2000-07-18 The Johns Hopkins School Of Medicine Human embryonic pluripotent germ cells
US6099832A (en) 1997-05-28 2000-08-08 Genzyme Corporation Transplants for myocardial scars
US6110459A (en) 1997-05-28 2000-08-29 Mickle; Donald A. G. Transplants for myocardial scars and methods and cellular preparations
WO1999001546A1 (en) 1997-07-01 1999-01-14 Cor Therapeutics, Inc. Cloning and characterization of a human adenylyl cyclase
ATE307195T1 (en) 1997-07-14 2005-11-15 Osiris Therapeutics Inc CARDIAC MUSCLE REGENERATION USING MESENCHYMAL STEM CELLS
US5991668A (en) 1997-09-25 1999-11-23 Medtronic, Inc. Medical electrical lead
US5967986A (en) 1997-11-25 1999-10-19 Vascusense, Inc. Endoluminal implant with fluid flow sensing capability
US6231516B1 (en) 1997-10-14 2001-05-15 Vacusense, Inc. Endoluminal implant with therapeutic and diagnostic capability
TW368420B (en) 1997-11-04 1999-09-01 Genetronics Inc Apparatus and method for transdermal molecular delivery by applying sufficient amplitude of electric field to induce migration of molecules through pores in the stratum corneum
US6775569B2 (en) 1997-11-05 2004-08-10 Hisamitsu Pharmaceutical Co., Inc. Electroporation device for in vivo delivery of therapeutic agents
US6775574B1 (en) 1997-11-07 2004-08-10 Medtronic, Inc. Method and system for myocardial infarction repair
US6151525A (en) 1997-11-07 2000-11-21 Medtronic, Inc. Method and system for myocardial identifier repair
US7031775B2 (en) 1997-11-07 2006-04-18 Medtronic, Inc. Method and system for myocardial infarction repair
US6237398B1 (en) 1997-12-30 2001-05-29 Remon Medical Technologies, Ltd. System and method for monitoring pressure, flow and constriction parameters of plumbing and blood vessels
US6140740A (en) 1997-12-30 2000-10-31 Remon Medical Technologies, Ltd. Piezoelectric transducer
US6541116B2 (en) 1998-01-30 2003-04-01 Advanced Cardiovascular Systems, Inc. Superoxide dismutase or superoxide dismutase mimic coating for an intracorporeal medical device
US6221425B1 (en) 1998-01-30 2001-04-24 Advanced Cardiovascular Systems, Inc. Lubricious hydrophilic coating for an intracorporeal medical device
US20030129750A1 (en) 1998-02-05 2003-07-10 Yitzhack Schwartz Homing of donor cells to a target zone in tissue using active therapeutics or substances
US20030113303A1 (en) 1998-02-05 2003-06-19 Yitzhack Schwartz Homing of embryonic stem cells to a target zone in tissue using active therapeutics or substances
DE69838526T2 (en) 1998-02-05 2008-07-03 Biosense Webster, Inc., Diamond Bar Device for releasing a drug in the heart
US20030125615A1 (en) 1998-02-05 2003-07-03 Yitzhack Schwartz Homing of autologous cells to a target zone in tissue using active therapeutics or substances
PL342996A1 (en) 1998-02-23 2001-07-16 Mnemoscience Gmbh Shape memory polymers
US6199554B1 (en) 1998-03-27 2001-03-13 The Brigham And Women's Hospital, Inc. Method and apparatus for combining injury-mediated therapy and drug delivery
US5902324A (en) * 1998-04-28 1999-05-11 Medtronic, Inc. Bi-atrial and/or bi-ventricular sequential cardiac pacing systems
US6206914B1 (en) 1998-04-30 2001-03-27 Medtronic, Inc. Implantable system with drug-eluting cells for on-demand local drug delivery
US7158830B2 (en) 1998-05-08 2007-01-02 Cardiac Pacemakers, Inc. Method and apparatus for optimizing stroke volume during DDD resynchronization therapy using adjustable atrio-ventricular delays
US7110817B2 (en) 1998-05-08 2006-09-19 Cardiac Pacemakers, Inc. Method and apparatus for optimizing ventricular synchrony during DDD resynchronization therapy using adjustable atrio-ventricular delays
AU770384B2 (en) 1998-05-30 2004-02-19 Collateral Therapeutics, Inc. Methods of altering cardiac cell phenotype
US6165164A (en) 1999-03-29 2000-12-26 Cordis Corporation Catheter for injecting therapeutic and diagnostic agents
US6540725B1 (en) 1998-06-04 2003-04-01 Biosense Webster, Inc. Injection catheter with controllably extendable injection needle
US6623474B1 (en) 1998-06-04 2003-09-23 Biosense Webster, Inc. Injection catheter with needle stop
US6575931B1 (en) 1998-06-04 2003-06-10 Biosense Webster, Inc. Catheter with injection needle
US7416547B2 (en) 1999-03-29 2008-08-26 Biosense Webster Inc. Injection catheter
US6905476B2 (en) 1998-06-04 2005-06-14 Biosense Webster, Inc. Catheter with injection needle
US6623473B1 (en) 1998-06-04 2003-09-23 Biosense Webster, Inc. Injection catheter with multi-directional delivery injection needle
US6185461B1 (en) 1998-07-01 2001-02-06 Pacesetter, Inc. System and method for verification of recommended replacement time indication in an implantable cardiac stimulation device
FR2780654B1 (en) 1998-07-06 2000-12-01 Ela Medical Sa ACTIVE IMPLANTABLE MEDICAL DEVICE FOR ELECTROSTIMULATION TREATMENT OF SLEEP APNEA SYNDROME
CA2337652C (en) 1998-07-13 2013-03-26 Genetronics, Inc. Skin and muscle-targeted gene therapy by pulsed electrical field
US6678556B1 (en) 1998-07-13 2004-01-13 Genetronics, Inc. Electrical field therapy with reduced histopathological change in muscle
US6117296A (en) 1998-07-21 2000-09-12 Thomson; Timothy Electrically controlled contractile polymer composite
US6050980A (en) 1998-08-03 2000-04-18 My-Tech, Inc Thromboresistant plastic article and method of manufacture
EP1102560A4 (en) 1998-08-07 2003-03-12 Infinite Biomedical Technologi Implantable myocardial ischemia detection, indication and action technology
US6759236B1 (en) 1998-08-18 2004-07-06 Research Development Foundation Methods to enhance and confine expression of genes
US6168801B1 (en) 1998-09-09 2001-01-02 Cardiac Pacemakers, Inc. Controlled release drug delivery
ATE294874T1 (en) 1998-09-11 2005-05-15 Univ California RECOMBINANT ADENOVIRUS FOR TISSUE-SPECIFIC GENE EXPRESSION INTO THE HEART
US7338798B2 (en) 1998-09-15 2008-03-04 The Regents Of The University Of Michigan System and method for forming a cardiac muscle construct
US6207451B1 (en) 1998-09-15 2001-03-27 The Regents Of The University Of Michigan Mammalian muscle construct and method for producing same
US6135976A (en) 1998-09-25 2000-10-24 Ekos Corporation Method, device and kit for performing gene therapy
US6016447A (en) 1998-10-27 2000-01-18 Medtronic, Inc. Pacemaker implant recognition
US6016448A (en) 1998-10-27 2000-01-18 Medtronic, Inc. Multilevel ERI for implantable medical devices
US6154675A (en) 1998-10-27 2000-11-28 Medtronic, Inc. Resetting ERI/POR/PIR/indicators in implantable medical devices
US6361780B1 (en) 1998-11-12 2002-03-26 Cardiac Pacemakers, Inc. Microporous drug delivery system
US6463323B1 (en) 1998-11-12 2002-10-08 Em Vascular, Inc. Electrically mediated angiogenesis
US6114164A (en) 1998-12-07 2000-09-05 The Regents Of The University Of Michigan System and method for emulating an in vivo environment of a muscle tissue specimen
US6115636A (en) 1998-12-22 2000-09-05 Medtronic, Inc. Telemetry for implantable devices using the body as an antenna
US6155267A (en) 1998-12-31 2000-12-05 Medtronic, Inc. Implantable medical device monitoring method and system regarding same
US6358202B1 (en) 1999-01-25 2002-03-19 Sun Microsystems, Inc. Network for implanted computer devices
AU765788B2 (en) 1999-02-10 2003-10-02 Gmp Drug Delivery, Inc. Iontophoresis, electroporation and combination patches for local drug delivery
US6112116A (en) 1999-02-22 2000-08-29 Cathco, Inc. Implantable responsive system for sensing and treating acute myocardial infarction
US6424847B1 (en) 1999-02-25 2002-07-23 Medtronic Minimed, Inc. Glucose monitor calibration methods
US6592623B1 (en) 1999-08-31 2003-07-15 Virginia Commonwealth University Intellectual Property Foundation Engineered muscle
US6128526A (en) 1999-03-29 2000-10-03 Medtronic, Inc. Method for ischemia detection and apparatus for using same
US6298272B1 (en) 1999-03-29 2001-10-02 Cardiac Pacemakers, Inc. High impedance electrode tip with internal drug delivery capability
US20040131601A1 (en) 2000-03-30 2004-07-08 Foundry Networks, Inc., A Delaward Corporation Injection of bone marrow-derived cells and medium for angiogenesis
US7097832B1 (en) 1999-03-30 2006-08-29 Myocardial Therapeutics, Inc. Intramyocardial injection of autologous bone marrow
US6284242B1 (en) 1999-04-16 2001-09-04 Regents Of The University Of Michigan Method for enhancing myoblast migration and invasion in the context of gene therapy
US6200265B1 (en) 1999-04-16 2001-03-13 Medtronic, Inc. Peripheral memory patch and access method for use with an implantable medical device
US6108577A (en) 1999-04-26 2000-08-22 Cardiac Pacemakers, Inc. Method and apparatus for detecting changes in electrocardiogram signals
US6309350B1 (en) 1999-05-03 2001-10-30 Tricardia, L.L.C. Pressure/temperature/monitor device for heart implantation
US6224566B1 (en) 1999-05-04 2001-05-01 Cardiodyne, Inc. Method and devices for creating a trap for confining therapeutic drugs and/or genes in the myocardium
US6261230B1 (en) 1999-06-03 2001-07-17 Cardiac Intelligence Corporation System and method for providing normalized voice feedback from an individual patient in an automated collection and analysis patient care system
US6270457B1 (en) 1999-06-03 2001-08-07 Cardiac Intelligence Corp. System and method for automated collection and analysis of regularly retrieved patient information for remote patient care
US6312378B1 (en) 1999-06-03 2001-11-06 Cardiac Intelligence Corporation System and method for automated collection and analysis of patient information retrieved from an implantable medical device for remote patient care
US7171263B2 (en) 1999-06-04 2007-01-30 Impulse Dynamics Nv Drug delivery device
US7092753B2 (en) * 1999-06-04 2006-08-15 Impulse Dynamics Nv Drug delivery device
AU781470B2 (en) * 1999-06-07 2005-05-26 Baxter Aktiengesellschaft Targeted angiogenesis
EP1067190A1 (en) 1999-07-09 2001-01-10 Introgene B.V. Gene therapy for enhancing and/or inducing angiogenesis
US6969382B2 (en) 1999-07-26 2005-11-29 Zuli Holdings, Ltd. Method and apparatus for treating bodily tissues with medicinal substance
US6221011B1 (en) 1999-07-26 2001-04-24 Cardiac Intelligence Corporation System and method for determining a reference baseline of individual patient status for use in an automated collection and analysis patient care system
US6410236B1 (en) 1999-09-01 2002-06-25 The Regents Of The University Of Michigan Correcting diastolic dysfunction in heart failure
US6330481B1 (en) 1999-10-04 2001-12-11 Medtronic Inc. Temporary medical electrical lead having biodegradable electrode mounting pad
US6463335B1 (en) 1999-10-04 2002-10-08 Medtronic, Inc. Temporary medical electrical lead having electrode mounting pad with biodegradable adhesive
US6385491B1 (en) 1999-10-04 2002-05-07 Medtronic, Inc. Temporary medical electrical lead having biodegradable electrode mounting pad loaded with therapeutic drug
US6587718B2 (en) 1999-10-08 2003-07-01 Scimed Life Systems, Inc. Iontophoretic delivery to heart tissue
US6361522B1 (en) 1999-10-21 2002-03-26 Cardiac Pacemakers, Inc. Drug delivery system for implantable cardiac device
US6459929B1 (en) 1999-11-04 2002-10-01 Cardiac Pacemakers, Inc. Implantable cardiac rhythm management device for assessing status of CHF patients
US6398728B1 (en) 1999-11-16 2002-06-04 Cardiac Intelligence Corporation Automated collection and analysis patient care system and method for diagnosing and monitoring respiratory insufficiency and outcomes thereof
US6368284B1 (en) 1999-11-16 2002-04-09 Cardiac Intelligence Corporation Automated collection and analysis patient care system and method for diagnosing and monitoring myocardial ischemia and outcomes thereof
US6411840B1 (en) 1999-11-16 2002-06-25 Cardiac Intelligence Corporation Automated collection and analysis patient care system and method for diagnosing and monitoring the outcomes of atrial fibrillation
US6336903B1 (en) 1999-11-16 2002-01-08 Cardiac Intelligence Corp. Automated collection and analysis patient care system and method for diagnosing and monitoring congestive heart failure and outcomes thereof
US6440066B1 (en) 1999-11-16 2002-08-27 Cardiac Intelligence Corporation Automated collection and analysis patient care system and method for ordering and prioritizing multiple health disorders to identify an index disorder
US6277078B1 (en) 1999-11-19 2001-08-21 Remon Medical Technologies, Ltd. System and method for monitoring a parameter associated with the performance of a heart
SE0000285D0 (en) 1999-12-07 2000-01-31 Mika Lahtinen Medical implant
US20040043006A1 (en) 2002-08-27 2004-03-04 Badylak Stephen F. Tissue regenerative composition
US20020142457A1 (en) 1999-12-28 2002-10-03 Akihiro Umezawa Cell having the potentiality of differentiation into cardiomyocytes
US6428802B1 (en) 1999-12-29 2002-08-06 Children's Medical Center Corp. Preparing artificial organs by forming polylayers of different cell populations on a substrate
US6818757B2 (en) 2000-01-14 2004-11-16 Beth Israel Deaconess Medical Center Cardiac-cell specific enhancer elements and uses thereof
US6919205B2 (en) * 2000-02-23 2005-07-19 The Trustees Of The University Of Pennsylvania Regulation of type II collagen gene expression using specific and selective electrical and electromagnetic signals
US6810286B2 (en) 2000-03-06 2004-10-26 Medtronic, Inc Stimulation for delivery of molecular therapy
US9522217B2 (en) 2000-03-15 2016-12-20 Orbusneich Medical, Inc. Medical device with coating for capturing genetically-altered cells and methods for using same
US6507756B1 (en) 2000-04-03 2003-01-14 Medtronic, Inc. Dual chamber pacing system having time-adaptive AV delay
WO2001076592A1 (en) 2000-04-06 2001-10-18 Acorda Therapeutics, Inc. Compositions and methods for promoting neural regeneration
DE60136925D1 (en) 2000-05-04 2009-01-22 Univ Oregon Health & Science ENDOVASCULAR STENT POWER
US6988004B2 (en) 2000-05-16 2006-01-17 Bioheart, Inc. Method for inducing angiogenesis by electrical stimulation of muscles
US6459917B1 (en) 2000-05-22 2002-10-01 Ashok Gowda Apparatus for access to interstitial fluid, blood, or blood plasma components
US6686188B2 (en) 2000-05-26 2004-02-03 Amersham Plc Polynucleotide encoding a human myosin-like polypeptide expressed predominantly in heart and muscle
TW495819B (en) * 2000-05-31 2002-07-21 Toshiba Corp Method and system for electronic commerce of semiconductor product, system and method of production, and design system, design method and manufacturing method of production equipment
US6902522B1 (en) 2000-06-12 2005-06-07 Acorn Cardiovascular, Inc. Cardiac disease treatment and device
US20020001577A1 (en) 2000-06-30 2002-01-03 Axel Haverich Use of cells with the ability to generate excitation within a cell preparation
US20020068729A1 (en) 2000-07-13 2002-06-06 Alteon, Inc. Method for treating fibrotic diseases or other indications IC
AU2001284695A1 (en) 2000-07-31 2002-02-13 New York Medical College Methods and compositions for the repair and/or regeneration of damaged myocardium
WO2002013671A2 (en) 2000-08-14 2002-02-21 Pharmacia Corporation Drug release (delivery system)
US6962814B2 (en) 2000-08-16 2005-11-08 Duke University Decellularized tissue engineered constructs and tissues
EP2363152A1 (en) * 2000-09-06 2011-09-07 Johns Hopkins University Cardiac arrhythmia treatment methods
US7158832B2 (en) 2000-09-27 2007-01-02 Cvrx, Inc. Electrode designs and methods of use for cardiovascular reflex control devices
US6690970B1 (en) 2000-10-06 2004-02-10 Syde A. Taheri Biological pacemaker and implantation catheter
US7491385B2 (en) 2001-09-05 2009-02-17 Genegrafts Ltd. Nucleic acid constructs and cells, and methods utilizing same for modifying the electrophysiological function of excitable tissues
US8417334B2 (en) 2000-10-26 2013-04-09 Medtronic, Inc. Method and apparatus for electrically stimulating the nervous system to improve ventricular dysfunction, heart failure, and other cardiac conditions
WO2002038794A2 (en) 2000-11-09 2002-05-16 The Brigham And Women's Hospital, Inc. Cardiovascular disease diagnostic and therapeutic targets
AU2002217795A1 (en) 2000-11-22 2002-06-03 Gwathmey, Inc. Isolation procedure and optimized media solution to enhance long-term survival of cells
US6689117B2 (en) 2000-12-18 2004-02-10 Cardiac Pacemakers, Inc. Drug delivery system for implantable medical device
JP4657577B2 (en) 2001-01-09 2011-03-23 マイクロチップス・インコーポレーテッド Flexible microchip device for ocular and other applications
EP1361896A2 (en) 2001-01-23 2003-11-19 Boston Scientific Corporation Localized myocardial injection method for treating ischemic myocardium
US6919207B2 (en) 2001-01-25 2005-07-19 The Trustees Of Columbia University In The City Of New York Method for regulating genes with electromagnetic response elements
US6571125B2 (en) 2001-02-12 2003-05-27 Medtronic, Inc. Drug delivery device
US7341062B2 (en) 2001-03-12 2008-03-11 Bioheart, Inc. Method of providing a dynamic cellular cardiac support
US20020124855A1 (en) 2001-03-12 2002-09-12 Chachques Juan C. Method of providing a dynamic cellular cardiac support
US6597951B2 (en) 2001-03-16 2003-07-22 Cardiac Pacemakers, Inc. Automatic selection from multiple cardiac optimization protocols
US6453195B1 (en) 2001-03-19 2002-09-17 Medtronic, Inc. Closed loop drug delivery system and remote management thereof
US20050283197A1 (en) 2001-04-10 2005-12-22 Daum Douglas R Systems and methods for hypotension
US20030045830A1 (en) 2001-04-17 2003-03-06 De Bizemont Therese Gene therapy with chimeric oligonucleotides delivered by a method comprising a step of iontophoresis
US6628988B2 (en) 2001-04-27 2003-09-30 Cardiac Pacemakers, Inc. Apparatus and method for reversal of myocardial remodeling with electrical stimulation
US6660737B2 (en) 2001-05-04 2003-12-09 The Procter & Gamble Company Medicinal uses of hydrazones
US6468263B1 (en) 2001-05-21 2002-10-22 Angel Medical Systems, Inc. Implantable responsive system for sensing and treating acute myocardial infarction and for treating stroke
US20030087264A1 (en) * 2001-05-22 2003-05-08 Kaplitt Michael G. Transcriptional regulation of target genes
US6887688B2 (en) 2001-05-29 2005-05-03 The Regents Of The University Of California Light controlled gene expression utilizing heterologous phytochromes
WO2002096362A2 (en) 2001-05-30 2002-12-05 Alteon Inc. Method for treating fibrotic diseases or other indications vi
US7044911B2 (en) 2001-06-29 2006-05-16 Philometron, Inc. Gateway platform for biological monitoring and delivery of therapeutic compounds
EP1416880B1 (en) 2001-07-16 2011-03-02 DePuy Products, Inc. Cartilage repair apparatus
US7481759B2 (en) 2001-08-03 2009-01-27 Cardiac Pacemakers, Inc. Systems and methods for treatment of coronary artery disease
US7020560B2 (en) 2001-09-06 2006-03-28 University Of Tennessee Research Foundation Methods for cell-based combinatorial logic
US7340303B2 (en) 2001-09-25 2008-03-04 Cardiac Pacemakers, Inc. Evoked response sensing for ischemia detection
US7215992B2 (en) 2001-10-31 2007-05-08 Cardiac Pacemakers, Inc. Method for ischemia detection by implantable cardiac device
US20030082148A1 (en) 2001-10-31 2003-05-01 Florian Ludwig Methods and device compositions for the recruitment of cells to blood contacting surfaces in vivo
CN1612691A (en) 2001-11-08 2005-05-04 加利福尼亚大学董事会 Methods and compositions for correction of cardiac conduction disturbances
US6973349B2 (en) 2001-12-05 2005-12-06 Cardiac Pacemakers, Inc. Method and apparatus for minimizing post-infarct ventricular remodeling
US7304137B2 (en) 2001-12-13 2007-12-04 The Texas A & M University System Nucleotide and amino acid sequences of asporins
US6666826B2 (en) 2002-01-04 2003-12-23 Cardiac Pacemakers, Inc. Method and apparatus for measuring left ventricular pressure
US6865420B1 (en) * 2002-01-14 2005-03-08 Pacesetter, Inc. Cardiac stimulation device for optimizing cardiac output with myocardial ischemia protection
US7407668B2 (en) 2002-01-24 2008-08-05 Boston Scimed, Inc. Medical articles having enzymatic surfaces for localized therapy
US6915160B2 (en) 2002-02-08 2005-07-05 Cardiac Pacemakers, Inc. Dynamically optimized multisite cardiac resynchronization device
US7622299B2 (en) 2002-02-22 2009-11-24 University Of Washington Bioengineered tissue substitutes
US7127291B2 (en) 2002-03-01 2006-10-24 Cardiac Pacemakers, Inc. Coronary sinus lead with thermal sensor and method therefor
US7221981B2 (en) 2002-03-28 2007-05-22 Northstar Neuroscience, Inc. Electrode geometries for efficient neural stimulation
US6969369B2 (en) * 2002-04-22 2005-11-29 Medtronic, Inc. Implantable drug delivery system responsive to intra-cardiac pressure
AU2003228858A1 (en) * 2002-05-02 2003-11-17 Scimed Life Systems, Inc. Energetically-controlled delivery of biologically active material from an implanted medical device
CN1713861A (en) 2002-05-02 2005-12-28 普渡研究基金会 Vascularization enhanced graft constructs
AU2003228808A1 (en) 2002-05-02 2003-11-17 Regents Of The University Of Minnesota Fibrin-based biomatrix
NZ536564A (en) 2002-05-02 2008-05-30 Purdue Research Foundation Vascularization enhanced graft constructs which comprise a matrix composition consisting of liver basement membrane
CN1684589A (en) 2002-05-02 2005-10-19 普渡研究基金会 Vascularization enhanced graft constructs
US7039462B2 (en) 2002-06-14 2006-05-02 Cardiac Pacemakers, Inc. Method and apparatus for detecting oscillations in cardiac rhythm
HUE027779T2 (en) 2002-05-09 2016-11-28 Brigham & Womens Hospital Inc 1L1RL-1 as a cardiovascular disease marker
US7375138B2 (en) 2002-05-18 2008-05-20 Sanofi-Aventis Deutschland Gmbh Pentafluorosulfanylbenzoylguanidines, processes for their preparation, their use as medicaments or diagnostic aids, and medicaments comprising them
US6965798B2 (en) 2002-06-17 2005-11-15 Kim Young D Implantable device for treating atrial fibrillation and method of using same
US7089055B2 (en) 2002-06-28 2006-08-08 Cardiac Pacemakers, Inc. Method and apparatus for delivering pre-shock defibrillation therapy
US20040014052A1 (en) 2002-07-22 2004-01-22 Kurtz Warren H. Process for regulating gene expression
WO2004009767A2 (en) 2002-07-23 2004-01-29 Boston Scientific Limited Cell therapy for regeneration
US6733996B2 (en) 2002-08-26 2004-05-11 Trustees Of Dartmouth College Methods for regulating gene expression using light
AU2003272378A1 (en) 2002-09-12 2004-04-30 X-Cell Medical, Inc. Apparatus and method for delivering compounds to a living organism
US7400931B2 (en) 2002-09-18 2008-07-15 Cardiac Pacemakers, Inc. Devices and methods to stimulate therapeutic angiogenesis for ischemia and heart failure
US6855124B1 (en) 2002-10-02 2005-02-15 Advanced Cardiovascular Systems, Inc. Flexible polymer needle catheter
US7415307B2 (en) * 2002-10-31 2008-08-19 Medtronic, Inc. Ischemia detection based on cardiac conduction time
US7072711B2 (en) * 2002-11-12 2006-07-04 Cardiac Pacemakers, Inc. Implantable device for delivering cardiac drug therapy
US7317950B2 (en) 2002-11-16 2008-01-08 The Regents Of The University Of California Cardiac stimulation system with delivery of conductive agent
EP1569717A2 (en) 2002-11-30 2005-09-07 Cardiac Pacemakers, Inc. Method and apparatus for cell and electrical therapy of living tissue
US7627373B2 (en) 2002-11-30 2009-12-01 Cardiac Pacemakers, Inc. Method and apparatus for cell and electrical therapy of living tissue
US20040158289A1 (en) 2002-11-30 2004-08-12 Girouard Steven D. Method and apparatus for cell and electrical therapy of living tissue
US7066891B2 (en) * 2002-12-20 2006-06-27 Medtronic, Inc. Method and apparatus for gauging severity of myocardial ischemic episodes
WO2004060476A2 (en) 2002-12-31 2004-07-22 The Johns Hopkins University Wound healing method and kits
US20050059153A1 (en) 2003-01-22 2005-03-17 George Frank R. Electromagnetic activation of gene expression and cell growth
US7702399B2 (en) 2003-04-11 2010-04-20 Cardiac Pacemakers, Inc. Subcutaneous electrode and lead with phoresis based pharmacological agent delivery
US8383158B2 (en) 2003-04-15 2013-02-26 Abbott Cardiovascular Systems Inc. Methods and compositions to treat myocardial conditions
US20040213770A1 (en) 2003-04-22 2004-10-28 Endobionics, Inc. Methods and systems for treating ischemic cardiac and other tissues
US20040215253A1 (en) 2003-04-24 2004-10-28 Weinberg Lisa P. Implantable cardiac stimulation device providing atrial accelerated arrhythmia termination electrode configuration selection and method
US20040214182A1 (en) 2003-04-25 2004-10-28 Vinod Sharma Genetic modification of targeted regions of the cardiac conduction system
US8013133B2 (en) 2003-04-25 2011-09-06 Medtronic, Inc. Genetic modification of targeted regions of the cardiac conduction system
US8367410B2 (en) 2003-06-20 2013-02-05 Massachusetts Institute Of Technology Application of electrical stimulation for functional tissue engineering in vitro and in vivo
WO2005002601A1 (en) 2003-06-25 2005-01-13 Badylak Stephen F Conditioned matrix compositions for tissue restoration
US6837231B1 (en) 2003-07-11 2005-01-04 General Motors Corporation Cylinder bank work output balancing based on exhaust gas A/F ratio
US20050013870A1 (en) 2003-07-17 2005-01-20 Toby Freyman Decellularized extracellular matrix of conditioned body tissues and uses thereof
US7320675B2 (en) 2003-08-21 2008-01-22 Cardiac Pacemakers, Inc. Method and apparatus for modulating cellular metabolism during post-ischemia or heart failure
US20050059999A1 (en) 2003-09-15 2005-03-17 Mongeon Luc R. Delivering genetic material to a stimulation site
FR2861997A1 (en) 2003-11-06 2005-05-13 Fred Zacouto Cardiac muscle stimulation device e.g. defibrillator, for use during tachycardia treatment, has impulse generator that sends stimulation pulse without delay at end of refractory period
AU2004293463A1 (en) 2003-11-20 2005-06-09 Angiotech International Ag Implantable sensors and implantable pumps and anti-scarring agents
US7512438B2 (en) 2003-11-26 2009-03-31 Angel Medical Systems, Inc. Implantable system for monitoring the condition of the heart
US20050123526A1 (en) * 2003-12-01 2005-06-09 Medtronic Inc. Administration of growth factors for neurogenesis and gliagenesis
US20050137626A1 (en) 2003-12-19 2005-06-23 Pastore Joseph M. Drug delivery system and method employing external drug delivery device in conjunction with computer network
US7215997B2 (en) 2003-12-22 2007-05-08 Cardiac Pacemakers, Inc. Dynamic device therapy control for treating post myocardial infarction patients
US7245973B2 (en) 2003-12-23 2007-07-17 Cardiac Pacemakers, Inc. His bundle mapping, pacing, and injection lead
US7115096B2 (en) 2003-12-24 2006-10-03 Cardiac Pacemakers, Inc. Third heart sound activity index for heart failure monitoring
US7840263B2 (en) 2004-02-27 2010-11-23 Cardiac Pacemakers, Inc. Method and apparatus for device controlled gene expression
US7299086B2 (en) 2004-03-05 2007-11-20 Cardiac Pacemakers, Inc. Wireless ECG in implantable devices
US7764995B2 (en) 2004-06-07 2010-07-27 Cardiac Pacemakers, Inc. Method and apparatus to modulate cellular regeneration post myocardial infarct
US7729761B2 (en) 2004-07-14 2010-06-01 Cardiac Pacemakers, Inc. Method and apparatus for controlled gene or protein delivery
US7621906B2 (en) 2004-08-25 2009-11-24 Cardiac Pacemakers, Inc. Method and apparatus to deliver drug and pacing therapy for treatment of cardiac disorders
US8060219B2 (en) 2004-12-20 2011-11-15 Cardiac Pacemakers, Inc. Epicardial patch including isolated extracellular matrix with pacing electrodes
US7981065B2 (en) 2004-12-20 2011-07-19 Cardiac Pacemakers, Inc. Lead electrode incorporating extracellular matrix
US20060134071A1 (en) 2004-12-20 2006-06-22 Jeffrey Ross Use of extracellular matrix and electrical therapy
US8874204B2 (en) 2004-12-20 2014-10-28 Cardiac Pacemakers, Inc. Implantable medical devices comprising isolated extracellular matrix
WO2007041463A2 (en) 2005-10-03 2007-04-12 Combinatorx, Incorporated Electrical devices and anti-scarring drug combinations

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030040777A1 (en) * 1996-01-08 2003-02-27 Itzik Shemer Modulation of intracellular calcium concentration using non-excitatory electrical signals applied to the tissue
WO1998002150A1 (en) * 1996-07-17 1998-01-22 Medtronic, Inc. System for genetically treating cardiac conduction disturbances
US20020049154A1 (en) * 1996-08-27 2002-04-25 University Of Utah Research Foundation Bioconjugates and delivery of bioactive agents
WO1999025385A1 (en) * 1997-11-17 1999-05-27 Imarx Pharmaceutical Corp. A method of increasing nucleic acid synthesis with ultrasound
US20020072785A1 (en) * 1999-12-14 2002-06-13 Medtronic, Inc. Apparatus and method for remote therapy and diagnosis in medical devices via interface systems
US20030204206A1 (en) * 2000-12-21 2003-10-30 Medtronic, Inc. Electrically responsive promoter system
WO2004080533A1 (en) * 2003-03-10 2004-09-23 Impulse Dynamics Nv Apparatus and method for delivering electrical signals to modify gene expression in cardiac tissue
WO2004093969A1 (en) * 2003-04-23 2004-11-04 Medtronic, Inc. System for the delivery of a biologic therapy with device monitoring and back-up

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
BUCHWALD A B ET AL: "Decoy oligodeoxynucleotide against activator protein-1 reduces neointimal proliferation after coronary angioplasty in hypercholesterolemic minipigs", JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, vol. 39, no. 4, 20 February 2002 (2002-02-20), pages 732 - 738, XP002327401, ISSN: 0735-1097 *
ZOU YUNZENG ET AL: "Heat shock transcription factor 1 protects cardiomyocytes from ischemia/reperfusion injury.", CIRCULATION. 16 DEC 2003, vol. 108, no. 24, 16 December 2003 (2003-12-16), pages 3024 - 3030, XP002345863, ISSN: 1524-4539 *

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7840263B2 (en) 2004-02-27 2010-11-23 Cardiac Pacemakers, Inc. Method and apparatus for device controlled gene expression
US7764995B2 (en) 2004-06-07 2010-07-27 Cardiac Pacemakers, Inc. Method and apparatus to modulate cellular regeneration post myocardial infarct
US7729761B2 (en) 2004-07-14 2010-06-01 Cardiac Pacemakers, Inc. Method and apparatus for controlled gene or protein delivery

Also Published As

Publication number Publication date
WO2005084751A2 (en) 2005-09-15
EP1729849A2 (en) 2006-12-13
JP2007531564A (en) 2007-11-08
US7840263B2 (en) 2010-11-23
US20050192637A1 (en) 2005-09-01

Similar Documents

Publication Publication Date Title
WO2005084751A3 (en) Implantable system for controlling gene expression
WO2011050282A3 (en) Massage device and control methods
WO2012003451A3 (en) Universal closed-loop electrical stimulation system
WO2007146490A3 (en) Physical conditioning system
WO2010065574A3 (en) Control knob
WO2011159527A3 (en) Automatic neural stimulation titration sweep
WO2018190586A3 (en) Aerosol generating device and method for providing adaptive feedback through puff recognition
WO2010067006A3 (en) Unit for charging a battery of a portable electric device
GB2436253B (en) Grid responsive control system
WO2006133102A3 (en) Agent delivery system and uses of the same
WO2007095087A3 (en) Programmable temperature control system for pools and spas
WO2007130774A3 (en) Myocardium conditioning using myocardial and parasympathetic stimulation
WO2007125534A3 (en) Improved functional electrical stimulation systems
WO2010027957A3 (en) Systems for characterizing physiologic parameters and methods for use therewith
WO2007089994A3 (en) Supply voltage control for a power amplifier
WO2008079840A3 (en) Rate adaptive cardiac pacing systems and methods
CR20190501A (en) Thermotherapy device and control method therefor
WO2008133956A3 (en) Robotic instrument control system
WO2010003730A3 (en) Controller and method for controlling a device connected to a power supply
WO2008134506A3 (en) Controlling fluid regulation
EP2079001A3 (en) Power supply controlling apparatus and program
AU308641S (en) Irrigation controller control panel
WO2008090438A3 (en) Apparatus for light control and method for light control
WO2007095612A3 (en) Method and device for delivering anti-tachycardia pacing therapy
WO2007098322A3 (en) Apparatus and methods of using card based programmable controllers

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BW BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE EG ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NA NI NO NZ OM PG PH PL PT RO RU SC SD SE SG SK SL SM SY TJ TM TN TR TT TZ UA UG US UZ VC VN YU ZA ZM ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): BW GH GM KE LS MW MZ NA SD SL SZ TZ UG ZM ZW AM AZ BY KG KZ MD RU TJ TM AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LT LU MC NL PL PT RO SE SI SK TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
WWE Wipo information: entry into national phase

Ref document number: 2007501003

Country of ref document: JP

WWE Wipo information: entry into national phase

Ref document number: 2005714075

Country of ref document: EP

WWP Wipo information: published in national office

Ref document number: 2005714075

Country of ref document: EP