WO2005084645A8 - Embolic particles - Google Patents

Embolic particles

Info

Publication number
WO2005084645A8
WO2005084645A8 PCT/US2005/006411 US2005006411W WO2005084645A8 WO 2005084645 A8 WO2005084645 A8 WO 2005084645A8 US 2005006411 W US2005006411 W US 2005006411W WO 2005084645 A8 WO2005084645 A8 WO 2005084645A8
Authority
WO
WIPO (PCT)
Prior art keywords
embolic particles
particles
embolic
embolization
compositions
Prior art date
Application number
PCT/US2005/006411
Other languages
French (fr)
Other versions
WO2005084645A1 (en
Inventor
Paul Dicarlo
Thomas V Ii Casey
Stephan P Mangin
Original Assignee
Boston Scient Scimed Inc
Paul Dicarlo
Thomas V Ii Casey
Stephan P Mangin
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boston Scient Scimed Inc, Paul Dicarlo, Thomas V Ii Casey, Stephan P Mangin filed Critical Boston Scient Scimed Inc
Priority to AT05724040T priority Critical patent/ATE432067T1/en
Priority to DE602005014628T priority patent/DE602005014628D1/en
Priority to EP05724040A priority patent/EP1742614B1/en
Priority to CA002556939A priority patent/CA2556939A1/en
Publication of WO2005084645A1 publication Critical patent/WO2005084645A1/en
Publication of WO2005084645A8 publication Critical patent/WO2005084645A8/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/04—Macromolecular materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/12—Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
    • A61B17/12022—Occluding by internal devices, e.g. balloons or releasable wires
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/12—Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
    • A61B17/12022—Occluding by internal devices, e.g. balloons or releasable wires
    • A61B17/12027—Type of occlusion
    • A61B17/12031—Type of occlusion complete occlusion
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/12—Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
    • A61B17/12022—Occluding by internal devices, e.g. balloons or releasable wires
    • A61B17/12027—Type of occlusion
    • A61B17/12036—Type of occlusion partial occlusion
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/12—Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
    • A61B17/12022—Occluding by internal devices, e.g. balloons or releasable wires
    • A61B17/12131—Occluding by internal devices, e.g. balloons or releasable wires characterised by the type of occluding device
    • A61B17/12181—Occluding by internal devices, e.g. balloons or releasable wires characterised by the type of occluding device formed by fluidized, gelatinous or cellular remodelable materials, e.g. embolic liquids, foams or extracellular matrices
    • A61B17/12186—Occluding by internal devices, e.g. balloons or releasable wires characterised by the type of occluding device formed by fluidized, gelatinous or cellular remodelable materials, e.g. embolic liquids, foams or extracellular matrices liquid materials adapted to be injected
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/167—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/001—Use of materials characterised by their function or physical properties
    • A61L24/0015—Medicaments; Biocides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/001—Use of materials characterised by their function or physical properties
    • A61L24/0036—Porous materials, e.g. foams or sponges
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
    • A61L24/046—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/42—Gynaecological or obstetrical instruments or methods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/12—Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
    • A61B17/12022—Occluding by internal devices, e.g. balloons or releasable wires
    • A61B2017/1205—Introduction devices
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
    • A61L2300/62—Encapsulated active agents, e.g. emulsified droplets
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/36—Materials or treatment for tissue regeneration for embolization or occlusion, e.g. vaso-occlusive compositions or devices
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
    • Y10T428/2991—Coated
    • Y10T428/2998—Coated including synthetic resin or polymer

Abstract

Embolization, as well as related particles, compositions, and methods, are disclosed.
PCT/US2005/006411 2004-03-02 2005-02-28 Embolic particles WO2005084645A1 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
AT05724040T ATE432067T1 (en) 2004-03-02 2005-02-28 EMBOLIC PARTICLES
DE602005014628T DE602005014628D1 (en) 2004-03-02 2005-02-28 EMBOLISM PARTICLES
EP05724040A EP1742614B1 (en) 2004-03-02 2005-02-28 Embolic particles
CA002556939A CA2556939A1 (en) 2004-03-02 2005-02-28 Embolic particles

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10/791,552 2004-03-02
US10/791,552 US7736671B2 (en) 2004-03-02 2004-03-02 Embolization

Publications (2)

Publication Number Publication Date
WO2005084645A1 WO2005084645A1 (en) 2005-09-15
WO2005084645A8 true WO2005084645A8 (en) 2005-11-03

Family

ID=34911665

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2005/006411 WO2005084645A1 (en) 2004-03-02 2005-02-28 Embolic particles

Country Status (6)

Country Link
US (4) US7736671B2 (en)
EP (1) EP1742614B1 (en)
AT (1) ATE432067T1 (en)
CA (1) CA2556939A1 (en)
DE (1) DE602005014628D1 (en)
WO (1) WO2005084645A1 (en)

Families Citing this family (56)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7976823B2 (en) 2003-08-29 2011-07-12 Boston Scientific Scimed, Inc. Ferromagnetic particles and methods
US20050273002A1 (en) 2004-06-04 2005-12-08 Goosen Ryan L Multi-mode imaging marker
US7736671B2 (en) * 2004-03-02 2010-06-15 Boston Scientific Scimed, Inc. Embolization
US8173176B2 (en) 2004-03-30 2012-05-08 Boston Scientific Scimed, Inc. Embolization
US7311861B2 (en) 2004-06-01 2007-12-25 Boston Scientific Scimed, Inc. Embolization
US8425550B2 (en) 2004-12-01 2013-04-23 Boston Scientific Scimed, Inc. Embolic coils
US7858183B2 (en) 2005-03-02 2010-12-28 Boston Scientific Scimed, Inc. Particles
US7727555B2 (en) 2005-03-02 2010-06-01 Boston Scientific Scimed, Inc. Particles
US7963287B2 (en) 2005-04-28 2011-06-21 Boston Scientific Scimed, Inc. Tissue-treatment methods
US9463426B2 (en) 2005-06-24 2016-10-11 Boston Scientific Scimed, Inc. Methods and systems for coating particles
US20070031338A1 (en) * 2005-08-02 2007-02-08 Zabinski Peter P Embolized cryoablation for treatment of tumors
US8007509B2 (en) 2005-10-12 2011-08-30 Boston Scientific Scimed, Inc. Coil assemblies, components and methods
US8152839B2 (en) 2005-12-19 2012-04-10 Boston Scientific Scimed, Inc. Embolic coils
US8101197B2 (en) 2005-12-19 2012-01-24 Stryker Corporation Forming coils
US7947368B2 (en) 2005-12-21 2011-05-24 Boston Scientific Scimed, Inc. Block copolymer particles
US20070208277A1 (en) * 2006-03-06 2007-09-06 Rioux Robert F Vessel volume determination for embolization
KR101443926B1 (en) 2006-06-15 2014-10-02 마이크로벤션, 인코포레이티드 Embolization device constructed from expansible polymer
US9375217B2 (en) * 2006-07-18 2016-06-28 Boston Scientific Scimed, Inc. Catheterizing body lumens
US10675298B2 (en) 2006-07-27 2020-06-09 Boston Scientific Scimed Inc. Particles
WO2008014060A2 (en) * 2006-07-27 2008-01-31 Boston Scientific Limited Microparticle
WO2008014065A1 (en) * 2006-07-27 2008-01-31 Boston Scientific Limited Particles
US8414927B2 (en) 2006-11-03 2013-04-09 Boston Scientific Scimed, Inc. Cross-linked polymer particles
US20090092675A1 (en) * 2007-10-05 2009-04-09 Boston Scientific Scimed, Inc. Compositions containing multiple polymers and particles made using the compositions
US7962223B2 (en) * 2007-11-16 2011-06-14 Boston Scientific Scimed, Inc. Ablation probe for drug release in tissue ablation procedures
EP2266639B1 (en) 2007-12-21 2016-10-05 MicroVention, Inc. Methods for preparing hydrogel filaments for biomedical use
US20090169471A1 (en) * 2007-12-28 2009-07-02 Boston Scientific Scimed, Inc. Particles for injection and processes for forming the same
WO2009086076A2 (en) * 2007-12-28 2009-07-09 Boston Scientific Scimed, Inc. Particles for injection and processes for forming the same
US10028747B2 (en) 2008-05-01 2018-07-24 Aneuclose Llc Coils with a series of proximally-and-distally-connected loops for occluding a cerebral aneurysm
US10716573B2 (en) 2008-05-01 2020-07-21 Aneuclose Janjua aneurysm net with a resilient neck-bridging portion for occluding a cerebral aneurysm
WO2010028047A1 (en) * 2008-09-02 2010-03-11 Cook Incorporated Erodible embolization material
WO2011014722A2 (en) * 2009-07-30 2011-02-03 Cook Incorporated Erodible embolization material
JP5722333B2 (en) 2009-10-26 2015-05-20 マイクロベンション インコーポレイテッド Embolization device composed of expandable polymer
US9358140B1 (en) 2009-11-18 2016-06-07 Aneuclose Llc Stent with outer member to embolize an aneurysm
WO2012145431A2 (en) 2011-04-18 2012-10-26 Microvention, Inc. Embolic devices
US9011884B2 (en) 2012-04-18 2015-04-21 Microvention, Inc. Embolic devices
US8906003B2 (en) 2012-06-05 2014-12-09 Cook Medical Technologies Llc Erodible embolization material for targeted tumor cryoablation
CA2876474C (en) 2012-06-14 2021-06-22 Microvention, Inc. Polymeric treatment compositions
CN104717983B (en) 2012-10-15 2018-09-18 微仙美国有限公司 It polymerize therapeutic combination
CA2923741C (en) 2013-09-19 2022-06-07 Microvention, Inc. Polymer films
KR102352098B1 (en) 2013-09-19 2022-01-14 테루모 가부시키가이샤 Polymer particles
AU2014346486B2 (en) 2013-11-08 2016-12-08 Terumo Corporation Polymer particles
WO2015143357A2 (en) * 2014-03-21 2015-09-24 Boston Scientific Scimed, Inc. Devices and methods for treating a lung
US10124090B2 (en) 2014-04-03 2018-11-13 Terumo Corporation Embolic devices
CN106413611A (en) 2014-04-17 2017-02-15 波士顿科学国际有限公司 Medical devices for therapeutic heat treatments
WO2015167752A1 (en) 2014-04-29 2015-11-05 Microvention, Inc. Polymers including active agents
WO2015167751A1 (en) 2014-04-29 2015-11-05 Microvention, Inc. Polymers
US9907880B2 (en) 2015-03-26 2018-03-06 Microvention, Inc. Particles
WO2016201250A1 (en) 2015-06-11 2016-12-15 Microvention, Inc. Expansile device for implantation
WO2017062565A1 (en) 2015-10-07 2017-04-13 Boston Scientific Scimed, Inc. Mixture of lafesih magnetic nanoparticles with different curie temperatures to improve inductive heating efficiency for hyperthermia therapy
US10368874B2 (en) 2016-08-26 2019-08-06 Microvention, Inc. Embolic compositions
JP6728499B2 (en) 2016-09-28 2020-07-22 テルモ株式会社 Polymer particles
CN110891550B (en) * 2017-07-13 2023-03-07 瓦里安医疗系统公司 Embolic microspheres
EP3694422A4 (en) 2017-10-09 2021-06-30 Microvention, Inc. Radioactive liquid embolic
US11590080B2 (en) 2017-12-18 2023-02-28 C.R. Bard, Inc. Drug-loaded biodegradable microbead compositions including drug-containing vesicular agents
CN112004528B (en) 2017-12-18 2023-01-03 巴德股份有限公司 Drug-loaded microbead compositions, embolic compositions, and related methods
CN109045347B (en) * 2018-08-19 2021-05-28 温州生物材料与工程研究所 Degradable drug-loaded hemostatic microsphere and preparation method thereof

Family Cites Families (349)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2275154A (en) 1940-07-10 1942-03-03 United Drug Company Method for making capsules
US2609347A (en) 1948-05-27 1952-09-02 Wilson Christopher Lumley Method of making expanded polyvinyl alcohol-formaldehyde reaction product and product resulting therefrom
US3615972A (en) * 1967-04-28 1971-10-26 Dow Chemical Co Expansible thermoplastic polymer particles containing volatile fluid foaming agent and method of foaming the same
JPS4820019B1 (en) 1969-06-05 1973-06-18
US3737398A (en) 1969-11-13 1973-06-05 D Yamaguchi Method of making a polyvinyl acetal sponge buff
CS179075B1 (en) 1974-11-26 1977-10-31 Stoy Vladimir Mode of manufacture of spherical particles from polymer
US4076640A (en) 1975-02-24 1978-02-28 Xerox Corporation Preparation of spheroidized particles
US3957933A (en) 1975-03-05 1976-05-18 General Atomic Company Apparatus for producing microspherical particles and method for operating such apparatus
JPS51135958A (en) 1975-05-20 1976-11-25 Fuji Photo Film Co Ltd Method of making fine powder polymer having pores
US4025686A (en) 1975-06-26 1977-05-24 Owens-Corning Fiberglas Corporation Molded composite article and method for making the article
US4034759A (en) 1975-08-27 1977-07-12 Xomed, Inc. Moisture-expandable prosthesis
US4098728A (en) 1976-01-02 1978-07-04 Solomon Rosenblatt Medical surgical sponge and method of making same
US4055377A (en) 1976-08-03 1977-10-25 Minnesota Mining And Manufacturing Company Magnetically orientable retroreflectorization particles
GB1591924A (en) 1976-10-25 1981-07-01 Berger Jenson & Nicholson Ltd Polymer aggregates
US4159719A (en) 1977-05-09 1979-07-03 Xomed, Inc. Moisture-expandable ear wick
EP0004587B1 (en) 1978-03-23 1983-02-09 Hoechst Aktiengesellschaft Polyvinyl alcohol pellets containing a plasticizer, and method for their preparation
DE2834539A1 (en) 1978-08-07 1980-02-21 Basf Ag MACROPOROUS POLYMERS AS CARRIER MATERIAL FOR THE COVALENT BINDING OF PROTEINS
US4793980A (en) 1978-09-21 1988-12-27 Torobin Leonard B Hollow porous microspheres as substrates and containers for catalyst
US4243794A (en) 1978-10-10 1981-01-06 Minnesota Mining And Manufacturing Company Mixture of rough and spheroidized resin particles
US4198318A (en) 1978-11-24 1980-04-15 Conoco, Inc. Production of high strength alumina spheres by hydrogelling corresponding slurries
US4268495A (en) 1979-01-08 1981-05-19 Ethicon, Inc. Injectable embolization and occlusion solution
US4246208A (en) 1979-03-22 1981-01-20 Xerox Corporation Dust-free plasma spheroidization
US4346712A (en) 1979-04-06 1982-08-31 Kuraray Company, Ltd. Releasable balloon catheter
HU184722B (en) 1980-02-18 1984-10-29 Laszlo Lazar Therapeutically suitable silicone rubber mixture and therapeuticaid
US4271281A (en) 1980-05-29 1981-06-02 American Hoechst Corporation Process for preparing styrenic polymer particles
DE3031737A1 (en) 1980-08-22 1982-04-01 Bayer Ag, 5090 Leverkusen METHOD FOR PRODUCING PEARL POLYMERISATS OF UNIFORM PARTICLE SIZE
CA1166413A (en) 1980-10-30 1984-05-01 Edward E. Timm Process and apparatus for preparing uniform size polymer beads
US4442843A (en) 1980-11-17 1984-04-17 Schering, Ag Microbubble precursors and methods for their production and use
US4657756A (en) 1980-11-17 1987-04-14 Schering Aktiengesellschaft Microbubble precursors and apparatus for their production and use
US4681119A (en) 1980-11-17 1987-07-21 Schering Aktiengesellschaft Method of production and use of microbubble precursors
NZ199916A (en) 1981-03-11 1985-07-12 Unilever Plc Low density polymeric block material for use as carrier for included liquids
US4413070A (en) 1981-03-30 1983-11-01 California Institute Of Technology Polyacrolein microspheres
US4622362A (en) 1981-03-30 1986-11-11 California Institute Of Technology Polyacrolein microspheres
US4678814A (en) 1981-03-30 1987-07-07 California Institute Of Technology Polyacrolein microspheres
CA1177811A (en) 1981-04-13 1984-11-13 Theo G. Spek Process for the preparation of silica particles; silica particles with a narrow pore diameter distribution, catalysts made therefrom and use of these catalysts
US4428869A (en) 1981-08-20 1984-01-31 International Flavors & Fragrances Inc. Cologne consisting of microcapsule suspension
US4456693A (en) 1982-03-08 1984-06-26 W. R. Grace & Co. Hydrocracking catalyst
US4452773A (en) 1982-04-05 1984-06-05 Canadian Patents And Development Limited Magnetic iron-dextran microspheres
US4472552A (en) 1982-09-27 1984-09-18 W. R. Grace & Co. Continuous process for making solid, free-flowing water dispersible PVA-aldehyde reaction product
US4459145A (en) 1982-09-30 1984-07-10 The United States Of America As Represented By The United States Department Of Energy Fabrication of glass microspheres with conducting surfaces
JPS59131355A (en) 1983-01-17 1984-07-28 森下仁丹株式会社 Multiple soft capsule
US4515906A (en) 1983-02-28 1985-05-07 Bend Research, Inc. Anisotropic microporous supports impregnated with polymeric ion-exchange materials
DE3834705A1 (en) 1988-10-07 1990-04-12 Schering Ag ULTRASONIC CONTRASTING AGENTS FROM GAS BUBBLES AND MICROPARTICLES CONTAINING FATTY ACID
DE3313947A1 (en) 1983-04-15 1984-10-18 Schering AG, 1000 Berlin und 4709 Bergkamen MICROPARTICLES AND GAS BUBBLES CONTAINING ULTRASONIC CONTRASTING AGENTS
DE3313946A1 (en) 1983-04-15 1984-10-18 Schering AG, 1000 Berlin und 4709 Bergkamen MICROPARTICLES AND GAS BUBBLES CONTAINING ULTRASONIC CONTRASTING AGENTS
CA1225585A (en) 1983-06-30 1987-08-18 Maria T. Litvinova Composition for embolization of blood vessels
US4492720A (en) 1983-11-15 1985-01-08 Benjamin Mosier Method of preparing microspheres for intravascular delivery
US4573967A (en) 1983-12-06 1986-03-04 Eli Lilly And Company Vacuum vial infusion system
US4671954A (en) 1983-12-13 1987-06-09 University Of Florida Microspheres for incorporation of therapeutic substances and methods of preparation thereof
US4551436A (en) 1984-04-11 1985-11-05 General Electric Company Fabrication of small dense silicon carbide spheres
DE3414924A1 (en) 1984-04-19 1985-10-31 Klaus Dr.med. Dr.med.habil. 8000 München Draenert COATED ANCHORAGE PART FOR IMPLANTS
US4674480A (en) 1984-05-25 1987-06-23 Lemelson Jerome H Drug compositions and methods of applying same
FR2566384B1 (en) 1984-06-21 1986-09-05 Saint Gobain Vitrage IMPROVEMENTS IN TECHNIQUES FOR THE PRODUCTION OF GLASS MICROSPHERES
DE3527482A1 (en) 1984-07-31 1986-02-06 Fuji Spinning Co., Ltd., Tokio/Tokyo METHOD FOR PRODUCING GRAINY POROUS CHITOSAN
GB8419708D0 (en) 1984-08-02 1984-09-05 Shell Int Research Preparation of silica spheres
US4623706A (en) 1984-08-23 1986-11-18 The Dow Chemical Company Process for preparing uniformly sized polymer particles by suspension polymerization of vibratorily excited monomers in a gaseous or liquid stream
US4629464A (en) 1984-09-25 1986-12-16 Tdk Corporation Porous hydroxyapatite material for artificial bone substitute
JPS61101242A (en) 1984-10-22 1986-05-20 Showa Denko Kk Production of coated substance
US4789501A (en) 1984-11-19 1988-12-06 The Curators Of The University Of Missouri Glass microspheres
US4675113A (en) 1984-11-28 1987-06-23 University Patents, Inc. Affinity chromatography using dried calcium alginate-magnetite separation media in a magnetically stabilized fluidized bed
EP0184198B1 (en) 1984-12-06 1989-03-01 Kanegafuchi Kagaku Kogyo Kabushiki Kaisha A method of preparation of droplets
US5106903A (en) 1984-12-17 1992-04-21 Lehigh University Preparation of large particle size monodisperse latexes
US4897255A (en) 1985-01-14 1990-01-30 Neorx Corporation Metal radionuclide labeled proteins for diagnosis and therapy
JPH0678460B2 (en) 1985-05-01 1994-10-05 株式会社バイオマテリアル・ユニバース Porous transparent polyvinyl alcohol gel
JPS61293911A (en) 1985-06-24 1986-12-24 Teisan Seiyaku Kk Sustained release preparation
SE459005B (en) 1985-07-12 1989-05-29 Aake Rikard Lindahl SET TO MANUFACTURE SPHERICAL POLYMER PARTICLES
USH915H (en) 1985-07-22 1991-05-07 Gibbs Marylu B Controlled macroporous copolymer properties by removal of impurities in the diluent
US4742086A (en) 1985-11-02 1988-05-03 Lion Corporation Process for manufacturing porous polymer
DE3543348A1 (en) 1985-12-07 1987-06-11 Bayer Ag PEARL-SHAPED CROSS-NETWORKED MIXED POLYMERS WITH EPOXY AND BASIC AMINO GROUPS, METHOD FOR THE PRODUCTION THEREOF AND THEIR USE
JPS62169723A (en) 1986-01-22 1987-07-25 Teisan Seiyaku Kk Sustained release preparation
GB8610024D0 (en) 1986-04-24 1986-05-29 Unilever Plc Porous structures
US4929400A (en) 1986-04-28 1990-05-29 California Institute Of Technology Production of monodisperse, polymeric microspheres
US5262176A (en) 1986-07-03 1993-11-16 Advanced Magnetics, Inc. Synthesis of polysaccharide covered superparamagnetic oxide colloids
JPS6317904A (en) 1986-07-09 1988-01-25 Mitsubishi Chem Ind Ltd Production of crosslinked porous polyvinyl alcohol particle
US4743507A (en) 1986-09-12 1988-05-10 Franses Elias I Nonspherical microparticles and method therefor
US5114421A (en) 1986-09-22 1992-05-19 Polak Robert B Medicament container/dispenser assembly
US4859711A (en) 1986-10-01 1989-08-22 Alcan International Limited Hollow microspheres
CA1287459C (en) 1986-10-01 1991-08-13 Mukesh Jain Process for the preparation of hollow microspheres
US5263992A (en) 1986-10-17 1993-11-23 Bio-Metric Systems, Inc. Biocompatible device with covalently bonded biocompatible agent
DE3787700T3 (en) 1986-10-29 1998-12-24 Kanegafuchi Chemical Ind Uniform polymer particles.
US5292814A (en) 1987-04-29 1994-03-08 Ernst Bayer Process for the preparation of monodispersed polymer beads
US4795741A (en) 1987-05-06 1989-01-03 Biomatrix, Inc. Compositions for therapeutic percutaneous embolization and the use thereof
GB8713263D0 (en) 1987-06-05 1987-07-08 Unilever Plc Spheroidal silica
JPH0612993B2 (en) 1987-08-10 1994-02-23 株式会社クラレ Method for producing spherical microbe-immobilized moldings
US4819637A (en) 1987-09-01 1989-04-11 Interventional Therapeutics Corporation System for artificial vessel embolization and devices for use therewith
JPH0762054B2 (en) 1987-10-13 1995-07-05 倉敷紡績株式会社 Crosslinked polymer particles
US4804366A (en) 1987-10-29 1989-02-14 Baxter International Inc. Cartridge and adapter for introducing a beneficial agent into an intravenous delivery system
US4850978A (en) 1987-10-29 1989-07-25 Baxter International Inc. Drug delivery cartridge with protective cover
US4981625A (en) 1988-03-14 1991-01-01 California Institute Of Technology Monodisperse, polymeric microspheres produced by irradiation of slowly thawing frozen drops
FR2634376B1 (en) 1988-07-21 1992-04-17 Farmalyoc NOVEL SOLID AND POROUS UNIT FORM COMPRISING MICROPARTICLES AND / OR NANOPARTICLES, AS WELL AS ITS PREPARATION
JP2836878B2 (en) 1988-08-24 1998-12-14 スリピアン，マービン，ジェイ Intraluminal sealing with biodegradable polymer material
DE3829938A1 (en) 1988-09-02 1990-03-29 Hermann Hofmann ORGANO-MINERAL DUENGER AND METHOD FOR THE PRODUCTION THEREOF
US4933372A (en) 1988-09-26 1990-06-12 Supelco, Inc. Porous rigid resins and process of preparation
US5047438A (en) 1988-09-26 1991-09-10 Supelco, Inc. Porous rigid resins and process of preparation
US5681576A (en) 1988-11-16 1997-10-28 Mdv Technologies, Inc. Method and composition for post surgical adhesion reduction
DE3841401A1 (en) 1988-12-08 1990-06-13 Martin Lemperle ALLOPLASTIC IMPLANT
US5258028A (en) 1988-12-12 1993-11-02 Ersek Robert A Textured micro implants
US4946899A (en) 1988-12-16 1990-08-07 The University Of Akron Thermoplastic elastomers of isobutylene and process of preparation
GB8900376D0 (en) 1989-01-09 1989-03-08 Nycomed As Iodinated esters
US5091205A (en) 1989-01-17 1992-02-25 Union Carbide Chemicals & Plastics Technology Corporation Hydrophilic lubricious coatings
FR2641692A1 (en) 1989-01-17 1990-07-20 Nippon Zeon Co Plug for closing an opening for a medical application, and device for the closure plug making use thereof
US5032117A (en) 1989-01-30 1991-07-16 Motta Louis J Tandem syringe
GB8905934D0 (en) 1989-03-15 1989-04-26 Dow Europ Sa A process for preparing adsorptive porous resin beads
US5888930A (en) * 1989-03-27 1999-03-30 Bend Research, Inc. Asymmetric microporous beads for controlled release
CA2017570C (en) 1989-05-31 2000-12-19 James R. Gross Porous structure of an absorbent polymer
US5354290A (en) 1989-05-31 1994-10-11 Kimberly-Clark Corporation Porous structure of an absorbent polymer
US5007940A (en) 1989-06-09 1991-04-16 American Medical Systems, Inc. Injectable polymeric bodies
US5116387A (en) 1989-06-09 1992-05-26 American Medical Systems, Inc. Preparation of injectable polymeric bodies
US5158573A (en) 1989-06-09 1992-10-27 American Medical Systems, Inc. Injectable polymeric bodies
US5190760A (en) 1989-07-08 1993-03-02 Coopers Animal Health Limited Solid pharmaceutical composition
US5698271A (en) 1989-08-22 1997-12-16 Immunivest Corporation Methods for the manufacture of magnetically responsive particles
US5253991A (en) 1989-11-20 1993-10-19 Sumitomo Cement Co., Ltd. Apparatus for producing spheroidal inorganic particulate material
US5580575A (en) 1989-12-22 1996-12-03 Imarx Pharmaceutical Corp. Therapeutic drug delivery systems
US5922304A (en) 1989-12-22 1999-07-13 Imarx Pharmaceutical Corp. Gaseous precursor filled microspheres as magnetic resonance imaging contrast agents
US5542935A (en) 1989-12-22 1996-08-06 Imarx Pharmaceutical Corp. Therapeutic delivery systems related applications
US5585112A (en) 1989-12-22 1996-12-17 Imarx Pharmaceutical Corp. Method of preparing gas and gaseous precursor-filled microspheres
US5469854A (en) 1989-12-22 1995-11-28 Imarx Pharmaceutical Corp. Methods of preparing gas-filled liposomes
US6306427B1 (en) 1989-12-28 2001-10-23 Rhone-Poulenc Nutrition Animale Pellets containing active ingredients protected against degradation in the rumen of ruminants
US5435645A (en) 1989-12-29 1995-07-25 Tecres Spa Process and apparatus for the mixing and direct emplacement of a two-component bone cement
US5147937A (en) 1990-03-22 1992-09-15 Rohm And Haas Company Process for making controlled, uniform-sized particles in the 1 to 50 micrometer range
US5556610A (en) 1992-01-24 1996-09-17 Bracco Research S.A. Gas mixtures useful as ultrasound contrast media, contrast agents containing the media and method
JPH03297475A (en) 1990-04-16 1991-12-27 Ken Ishihara Controlling method for emission of medicine by means of resonance sound wave
US5514090A (en) 1990-04-24 1996-05-07 Science Incorporated Closed drug delivery system
US5137928A (en) 1990-04-26 1992-08-11 Hoechst Aktiengesellschaft Ultrasonic contrast agents, processes for their preparation and the use thereof as diagnostic and therapeutic agents
CA2016870C (en) 1990-05-15 1994-03-29 Arnie Drudik Dispenser for storing and mixing several components
AU636481B2 (en) 1990-05-18 1993-04-29 Bracco International B.V. Polymeric gas or air filled microballoons usable as suspensions in liquid carriers for ultrasonic echography
JP2514087Y2 (en) 1990-05-25 1996-10-16 幸三 牧田 Balloon with detachable double-sided check valve
US6291605B1 (en) 1990-06-06 2001-09-18 Clarence S. Freeman Polymerization process with spraying step
EP0533799B1 (en) 1990-06-20 1995-10-18 Advanced Polymer Systems, Inc. Compositions and methods for the controlled release of soluble active substances
US5202352A (en) 1990-08-08 1993-04-13 Takeda Chemical Industries, Ltd. Intravascular embolizing agent containing angiogenesis-inhibiting substance
US5484584A (en) 1990-10-02 1996-01-16 Board Of Regents, The University Of Texas System Therapeutic and diagnostic use of modified polymeric microcapsules
US5149543A (en) 1990-10-05 1992-09-22 Massachusetts Institute Of Technology Ionically cross-linked polymeric microcapsules
US5120349A (en) 1990-12-07 1992-06-09 Landec Labs, Inc. Microcapsule having temperature-dependent permeability profile
US5171214A (en) 1990-12-26 1992-12-15 Abbott Laboratories Drug storage and delivery system
US5171217A (en) 1991-02-28 1992-12-15 Indiana University Foundation Method for delivery of smooth muscle cell inhibitors
US5147631A (en) 1991-04-30 1992-09-15 Du Pont Merck Pharmaceutical Company Porous inorganic ultrasound contrast agents
FR2676927B1 (en) 1991-05-29 1995-06-23 Ibf MICROSPHERES FOR USE IN THERAPEUTIC VASCULAR OCCLUSIONS AND INJECTABLE SOLUTIONS CONTAINING THEM.
WO1992021382A1 (en) 1991-06-03 1992-12-10 Holmes, Michael, John Improvements in or relating to contrast agents
GB9116610D0 (en) 1991-08-01 1991-09-18 Danbiosyst Uk Preparation of microparticles
US5216096A (en) 1991-09-24 1993-06-01 Japan Synthetic Rubber Co., Ltd. Process for the preparation of cross-linked polymer particles
US5811447A (en) 1993-01-28 1998-09-22 Neorx Corporation Therapeutic inhibitor of vascular smooth muscle cells
DE69220317T2 (en) 1991-10-01 1997-10-16 Takeda Chemical Industries Ltd Microparticle summary for extended release and manufacture of the same
JP3356447B2 (en) 1991-10-16 2002-12-16 テルモ株式会社 Vascular lesion embolic material composed of dried polymer gel
US5258042A (en) 1991-12-16 1993-11-02 Henry Ford Health System Intravascular hydrogel implant
DE69226203T2 (en) 1991-12-20 1998-12-10 Allied Signal Inc MATERIALS WITH LOW DENSITY AND HIGH SPECIFIC SURFACE AND ARTICLES MOLDED THEREOF FOR USE IN METAL RECOVERY
US5260002A (en) 1991-12-23 1993-11-09 Vanderbilt University Method and apparatus for producing uniform polymeric spheres
WO1993013111A1 (en) 1991-12-24 1993-07-08 E.I. Du Pont De Nemours And Company Dual stabilized microparticles
GB9200388D0 (en) 1992-01-09 1992-02-26 Nycomed As Improvements in or relating to contrast agents
GB9200391D0 (en) 1992-01-09 1992-02-26 Nycomed As Improvements in or relating to contrast agents
US6537574B1 (en) 1992-02-11 2003-03-25 Bioform, Inc. Soft tissue augmentation material
US5480644A (en) 1992-02-28 1996-01-02 Jsf Consultants Ltd. Use of injectable biomaterials for the repair and augmentation of the anal sphincters
BR9306044A (en) 1992-03-06 1997-11-18 Nycomed Imaging Contrast agent use the same processes to generate enhanced images of a human or non-human animal body and to prepare a contrast agent
EP0636014B1 (en) 1992-04-06 1998-05-27 Uroplasty, Inc. Treatment of reflux disorder by microparticles injection
DE69306844T2 (en) 1992-04-10 1997-07-10 Mitsubishi Chem Corp Process for the preparation of spherical cross-linked acrylonitrile copolymers
US6235313B1 (en) 1992-04-24 2001-05-22 Brown University Research Foundation Bioadhesive microspheres and their use as drug delivery and imaging systems
AU4198793A (en) 1992-07-24 1994-01-27 Takeda Chemical Industries Ltd. Microparticle preparation and production thereof
US5807323A (en) 1992-08-13 1998-09-15 Science Incorporated Mixing and delivery syringe assembly
US6592859B1 (en) 1992-08-20 2003-07-15 Ethicon, Inc. Controlled expansion sphincter augmentation media
US5512604A (en) 1992-08-28 1996-04-30 The Dow Chemical Company Porous copolymers having a cellular polymeric structure suitable for preparing ion-exchange resins and adsorbents
WO1994006477A1 (en) 1992-09-16 1994-03-31 Holmes, Michael, John Improvements in or relating to contrast agents
WO1994006460A1 (en) 1992-09-21 1994-03-31 Vitaphore Corporation Embolization plugs for blood vessels
DE4232755A1 (en) 1992-09-26 1994-03-31 Schering Ag Microparticle preparations made from biodegradable copolymers
KR960001417B1 (en) 1992-09-26 1996-01-27 한국과학기술원 Method for preparing an improved porous polymer bead
GB9221329D0 (en) 1992-10-10 1992-11-25 Delta Biotechnology Ltd Preparation of further diagnostic agents
US5382260A (en) 1992-10-30 1995-01-17 Interventional Therapeutics Corp. Embolization device and apparatus including an introducer cartridge and method for delivering the same
US5369163A (en) 1992-11-13 1994-11-29 Rohm And Haas Company Process for preparing large dimension emulsion polymer particles, polymer product and uses thereof
US5690666A (en) 1992-11-18 1997-11-25 Target Therapeutics, Inc. Ultrasoft embolism coils and process for using them
US5349957A (en) 1992-12-02 1994-09-27 Sterling Winthrop Inc. Preparation and magnetic properties of very small magnetite-dextran particles
JP3256583B2 (en) 1992-12-10 2002-02-12 株式会社リコー Electrophotographic toner and method for producing the same
US5288763A (en) 1992-12-23 1994-02-22 The Johns Hopkins University School Of Medicine Porous, polymer beads and process of their preparation
US6482436B1 (en) 1993-01-29 2002-11-19 Ferx Incorporated Magnetically responsive composition
US5328936A (en) 1993-02-01 1994-07-12 Rohm And Haas Company Polymerization process for making porous polymeric particles
US6090925A (en) 1993-03-09 2000-07-18 Epic Therapeutics, Inc. Macromolecular microparticles and methods of production and use
US5320639A (en) 1993-03-12 1994-06-14 Meadox Medicals, Inc. Vascular plug delivery system
US5701899A (en) 1993-05-12 1997-12-30 The Board Of Regents Of The University Of Nebraska Perfluorobutane ultrasound contrast agent and methods for its manufacture and use
US5695740A (en) 1993-05-12 1997-12-09 The Board Of Regents Of The University Of Nebraska Perfluorocarbon ultrasound contrast agent comprising microbubbles containing a filmogenic protein and a saccharide
US5567415A (en) 1993-05-12 1996-10-22 The Board Of Regents Of The University Of Nebraska Ultrasound contrast agents and methods for their manufacture and use
US5344867A (en) 1993-06-14 1994-09-06 The Bfgoodrich Company Vinylidene chloride emulsion interpolymer composition
US5886026A (en) 1993-07-19 1999-03-23 Angiotech Pharmaceuticals Inc. Anti-angiogenic compositions and methods of use
WO1995003036A1 (en) 1993-07-19 1995-02-02 Angiogenesis Technologies, Inc. Anti-angiogenic compositions and methods of use
US5398851A (en) 1993-08-06 1995-03-21 River Medical, Inc. Liquid delivery device
US5397303A (en) 1993-08-06 1995-03-14 River Medical, Inc. Liquid delivery device having a vial attachment or adapter incorporated therein
US5443495A (en) 1993-09-17 1995-08-22 Scimed Lifesystems Inc. Polymerization angioplasty balloon implant device
US5531716A (en) 1993-09-29 1996-07-02 Hercules Incorporated Medical devices subject to triggered disintegration
US5556391A (en) 1993-10-01 1996-09-17 Merocel Corporation Surgical sponge device
EP1258262A3 (en) 1993-10-28 2002-12-18 Medrad, Inc. Total system for contrast delivery
PT682530E (en) 1993-12-15 2003-06-30 Bracco Research Sa UTEIS GAS MIXTURES AS CONTRAST MEANS FOR ULTRASSONS
ATE281886T1 (en) 1994-01-21 2004-11-15 Sirtex Medical Ltd YTTRIA PARTICULATE GOOD
US5569468A (en) 1994-02-17 1996-10-29 Modi; Pankaj Vaccine delivery system for immunization, using biodegradable polymer microspheres
US5417982A (en) 1994-02-17 1995-05-23 Modi; Pankaj Controlled release of drugs or hormones in biodegradable polymer microspheres
ATE173160T1 (en) 1994-02-17 1998-11-15 Pankaj Modi DRUGS, VACCINES AND HORMONES IN POLYLACTIDE-COATED MICROPARTICLES
AU705305B2 (en) 1994-03-18 1999-05-20 Cook Medical Technologies Llc Helical embolization coil
US5431174A (en) 1994-04-04 1995-07-11 Via Medical Corporation Method of fluid delivery and collection
EP0757553B1 (en) 1994-04-28 2000-08-02 Primed Halberstadt Medizintechnik Gmbh One-piece dispensing device for the contamination-free administration of medicaments (cytostatica)
US5534589A (en) 1994-05-04 1996-07-09 Minnesota Mining And Manufacturing Company Repulpable plastic films
DE69521997T2 (en) 1994-05-15 2002-04-04 Apbiotech Ab Uppsala METHOD FOR PRODUCING PARTICLES AND PARTICLES THAT CAN BE MANUFACTURED BY THIS PROCESS
JP2535785B2 (en) 1994-06-03 1996-09-18 工業技術院長 Vascular embolic agent
US5583162A (en) 1994-06-06 1996-12-10 Biopore Corporation Polymeric microbeads and method of preparation
US5639710A (en) 1994-07-06 1997-06-17 Zeneca Limited Solid microspheres for agriculturally active compounds and process for their production
ES2096521B1 (en) 1994-08-10 1997-11-16 Univ La Laguna BIODEGRADABLE SYNTHETIC POLYMER MICROSPHERES IN THE MANUFACTURE AND ELABORATION OF REACTIVE EQUIPMENT FOR THE PREPARATION OF RADIOPHARMACEUTICAL MEDICINES.
WO1996004954A1 (en) 1994-08-17 1996-02-22 Boston Scientific Corporation Implant, and method and device for inserting the implant
DE9414868U1 (en) 1994-09-13 1994-12-15 Klein Hans Martin Vascular embolization particles
US5827531A (en) 1994-12-02 1998-10-27 The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration Microcapsules and methods for making
US6099864A (en) 1994-12-02 2000-08-08 The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration In situ activation of microcapsules
DK175166B1 (en) 1995-01-03 2004-06-21 Cook William Europ Method of manufacturing an assembly for placing an embolization coil in the vascular system and such assembly as well as an apparatus for advancing the assembly
WO1996022736A1 (en) 1995-01-27 1996-08-01 Scimed Life Systems, Inc. Embolizing system
US6179817B1 (en) 1995-02-22 2001-01-30 Boston Scientific Corporation Hybrid coating for medical devices
ES2161825T3 (en) 1995-03-07 2001-12-16 Ethicon Inc MEANS TO INCREASE THE FUNCTION OF THE CONTROLLED EXPANSION SPHINTER.
US5876372A (en) 1995-03-22 1999-03-02 Abbott Laboratories Syringe system accomodating seperate prefilled barrels for two constituents
US5569193A (en) 1995-03-22 1996-10-29 Abbott Laboratories Syringe system accommodating separately storable prefilled containers for two constituents
US5785682A (en) 1995-03-22 1998-07-28 Abbott Laboratories Pre-filled syringe drug delivery system
US5637087A (en) 1995-03-22 1997-06-10 Abbott Laboratories Prefilled, two-constituent syringe
CA2216919C (en) 1995-03-28 2007-09-18 Fidia Advanced Biopolymers Srl Nanospheres comprising a biocompatible polysaccharide
US5779668A (en) 1995-03-29 1998-07-14 Abbott Laboratories Syringe barrel for lyophilization, reconstitution and administration
US6428771B1 (en) 1995-05-15 2002-08-06 Pharmaceutical Discovery Corporation Method for drug delivery to the pulmonary system
US6312407B1 (en) 1995-06-05 2001-11-06 Medtronic Percusurge, Inc. Occlusion of a vessel
US6214331B1 (en) 1995-06-06 2001-04-10 C. R. Bard, Inc. Process for the preparation of aqueous dispersions of particles of water-soluble polymers and the particles obtained
US5766147A (en) 1995-06-07 1998-06-16 Winfield Medical Vial adaptor for a liquid delivery device
US5657756A (en) 1995-06-07 1997-08-19 Ctf Systems Inc. Method and systems for obtaining higher order gradiometer measurements with lower order gradiometers
JP3450941B2 (en) * 1995-06-09 2003-09-29 コニカミノルタホールディングス株式会社 Fixing method
US6143211A (en) 1995-07-21 2000-11-07 Brown University Foundation Process for preparing microparticles through phase inversion phenomena
US5877224A (en) 1995-07-28 1999-03-02 Rutgers, The State University Of New Jersey Polymeric drug formulations
US5840387A (en) 1995-07-28 1998-11-24 Aegis Biosciences L.L.C. Sulfonated multiblock copolymer and uses therefor
US6096344A (en) 1995-07-28 2000-08-01 Advanced Polymer Systems, Inc. Bioerodible porous compositions
WO1997006195A1 (en) * 1995-08-03 1997-02-20 Santerre Paul J Fluoroligomer surface modifiers for polymers and articles made therefrom
US5558822A (en) 1995-08-16 1996-09-24 Gas Research Institute Method for production of spheroidized particles
US5888546A (en) 1995-08-28 1999-03-30 The Regents Of The University Of California Embolic material for endovascular occlusion of abnormal vasculature and method for using the same
US5833361A (en) 1995-09-07 1998-11-10 Funk; James E. Apparatus for the production of small spherical granules
CA2161863A1 (en) 1995-10-31 1997-05-01 Michael Vivian Sefton Angiogenic material and uses thereof
US5752974A (en) 1995-12-18 1998-05-19 Collagen Corporation Injectable or implantable biomaterials for filling or blocking lumens and voids of the body
WO1997025015A1 (en) 1996-01-11 1997-07-17 Duoject Medical Systems Inc. Delivery system for pharmaceuticals packed in pharmaceutical vials
US5702361A (en) 1996-01-31 1997-12-30 Micro Therapeutics, Inc. Method for embolizing blood vessels
US5895398A (en) 1996-02-02 1999-04-20 The Regents Of The University Of California Method of using a clot capture coil
US6051247A (en) 1996-05-30 2000-04-18 University Of Florida Research Foundation, Inc. Moldable bioactive compositions
US5855615A (en) 1996-06-07 1999-01-05 Menlo Care, Inc. Controller expansion sphincter augmentation media
US5792478A (en) 1996-07-08 1998-08-11 Advanced Uro Science Tissue injectable composition and method of use
US5830178A (en) 1996-10-11 1998-11-03 Micro Therapeutics, Inc. Methods for embolizing vascular sites with an emboilizing composition comprising dimethylsulfoxide
US5695480A (en) 1996-07-29 1997-12-09 Micro Therapeutics, Inc. Embolizing compositions
US5741331A (en) 1996-07-29 1998-04-21 Corvita Corporation Biostable elastomeric polymers having quaternary carbons
US5823198A (en) 1996-07-31 1998-10-20 Micro Therapeutics, Inc. Method and apparatus for intravasculer embolization
TW421658B (en) 1996-07-31 2001-02-11 Kanebo Ltd Porious spherical particles and the preparation process for preparing thereof
US5902832A (en) 1996-08-20 1999-05-11 Menlo Care, Inc. Method of synthesizing swollen hydrogel for sphincter augmentation
US5813411A (en) 1996-08-20 1998-09-29 Menlo Care, Inc. Method of deforming tissue with a swollen hydrogel
US5785642A (en) 1996-10-18 1998-07-28 Micro Therapeutics, Inc. Methods for treating urinary incontinence in mammals
US5756127A (en) 1996-10-29 1998-05-26 Wright Medical Technology, Inc. Implantable bioresorbable string of calcium sulfate beads
US6139963A (en) 1996-11-28 2000-10-31 Kuraray Co., Ltd. Polyvinyl alcohol hydrogel and process for producing the same
DE29724255U1 (en) 1996-12-18 2000-10-05 Alpha Bioverfahrenstechnik Gmb Microcapsules
US6090800A (en) 1997-05-06 2000-07-18 Imarx Pharmaceutical Corp. Lipid soluble steroid prodrugs
AU6893898A (en) 1997-04-10 1998-10-30 Johns Hopkins University, The Gaz syringe and package therefor
JP4102459B2 (en) 1997-05-14 2008-06-18 森下仁丹株式会社 Seamless capsule for synthesizing biopolymer and method for producing the same
US6056844A (en) 1997-06-06 2000-05-02 Triton Systems, Inc. Temperature-controlled induction heating of polymeric materials
JP2002503991A (en) 1997-06-13 2002-02-05 マイクロ・テラピューティクス・インコーポレーテッド Syringe and luer hub having novel shape and method of forming embolus
US6048908A (en) 1997-06-27 2000-04-11 Biopore Corporation Hydrophilic polymeric material
US5959073A (en) 1997-07-07 1999-09-28 Southwest Research Institute Method for preparing polymeric beads
US6056721A (en) 1997-08-08 2000-05-02 Sunscope International, Inc. Balloon catheter and method
EP1009317A4 (en) 1997-08-28 2001-01-24 Boston Scient Corp System for implanting a cross-linked polysaccharide fiber and methods of forming and inserting the fiber
US6476069B2 (en) 1997-09-11 2002-11-05 Provasis Therapeutics Inc. Compositions for creating embolic agents and uses thereof
US6538026B1 (en) 1997-09-11 2003-03-25 Provasis Therapeutics, Inc. Compositions useful for remodeling body spaces
AU739610B2 (en) 1997-11-07 2001-10-18 Salviac Limited Implantable occluder devices for medical use
US5951160A (en) 1997-11-20 1999-09-14 Biomet, Inc. Method and apparatus for packaging, mixing and delivering bone cement
DE19752585B4 (en) 1997-11-27 2007-06-28 Inotech Ag Device and method for encapsulating microbial, plant and animal cells or of biological and chemical substances
US6159192A (en) 1997-12-04 2000-12-12 Fowles; Thomas A. Sliding reconstitution device with seal
IL137299A0 (en) 1998-02-23 2001-07-24 Massachusetts Inst Technology Biodegradable shape memory polymers
JP3732404B2 (en) 1998-02-23 2006-01-05 ニーモサイエンス ゲーエムベーハー   Shape memory polymer composition, method of forming a shape memory product, and method of forming a composition that stores a shape
US6003566A (en) 1998-02-26 1999-12-21 Becton Dickinson And Company Vial transferset and method
US6059766A (en) 1998-02-27 2000-05-09 Micro Therapeutics, Inc. Gynecologic embolotherapy methods
US6660301B1 (en) 1998-03-06 2003-12-09 Biosphere Medical, Inc. Injectable microspheres for dermal augmentation and tissue bulking
US6458296B1 (en) 1998-03-07 2002-10-01 Inotech Ag Method and device for capsulating microbial, plant and animal cells or biological and chemical substances
US6047861A (en) 1998-04-15 2000-04-11 Vir Engineering, Inc. Two component fluid dispenser
US6224794B1 (en) 1998-05-06 2001-05-01 Angiotech Pharmaceuticals, Inc. Methods for microsphere production
US6224630B1 (en) 1998-05-29 2001-05-01 Advanced Bio Surfaces, Inc. Implantable tissue repair device
EP1082072B8 (en) 1998-06-04 2014-03-05 New York University Endovascular thin film devices for treating and preventing stroke
US6267154B1 (en) 1998-06-05 2001-07-31 Abbott Laboratories System for storing mixing and administering a drug
US6165193A (en) 1998-07-06 2000-12-26 Microvention, Inc. Vascular embolization with an expansible implant
US6099064A (en) 1998-07-10 2000-08-08 Lund Industries, Inc. Windshield visor for motor vehicles
US6264861B1 (en) 1998-08-05 2001-07-24 Xeikon Nv Method for producing rounded polymeric particles
US6315709B1 (en) 1998-08-07 2001-11-13 Stereotaxis, Inc. Magnetic vascular defect treatment system
US6152943A (en) 1998-08-14 2000-11-28 Incept Llc Methods and apparatus for intraluminal deposition of hydrogels
US6149664A (en) 1998-08-27 2000-11-21 Micrus Corporation Shape memory pusher introducer for vasoocclusive devices
US6296622B1 (en) 1998-12-21 2001-10-02 Micrus Corporation Endoluminal device delivery system using axially recovering shape memory material
CA2248592A1 (en) 1998-08-31 2000-02-29 Christopher D. Batich Microspheres for use in the treatment of cancer
US6077256A (en) 1998-10-06 2000-06-20 Mann; Michael J. Delivery of a composition to the lung
FR2784580B1 (en) 1998-10-16 2004-06-25 Biosepra Inc POLYVINYL-ALCOHOL MICROSPHERES AND METHODS OF MAKING THE SAME
US6238335B1 (en) 1998-12-11 2001-05-29 Enteric Medical Technologies, Inc. Method for treating gastroesophageal reflux disease and apparatus for use therewith
JP2000189511A (en) 1998-12-25 2000-07-11 Kaneka Medeikkusu:Kk Embolization material
US6162377A (en) 1999-02-23 2000-12-19 Alberta Research Council Inc. Apparatus and method for the formation of uniform spherical particles
US6296604B1 (en) 1999-03-17 2001-10-02 Stereotaxis, Inc. Methods of and compositions for treating vascular defects
US6306425B1 (en) 1999-04-09 2001-10-23 Southern Research Institute Injectable naltrexone microsphere compositions and their use in reducing consumption of heroin and alcohol
US6368658B1 (en) 1999-04-19 2002-04-09 Scimed Life Systems, Inc. Coating medical devices using air suspension
JP2000310832A (en) * 1999-04-28 2000-11-07 Konica Corp Black-and-white heat-developable photosensitive material and image forming method by using it
US6280457B1 (en) 1999-06-04 2001-08-28 Scimed Life Systems, Inc. Polymer covered vaso-occlusive devices and methods of producing such devices
ATE506021T1 (en) 1999-06-09 2011-05-15 Ethicon Inc DEVICE FOR ADJUSTING POLYMER IMPLANTS TO SOFT SURFACES
CN1248689C (en) 1999-08-27 2006-04-05 南方研究所 Injectable bupernorphine microparticle compositions and their use
FR2797769B1 (en) 1999-09-01 2003-07-25 Cis Bio Int RADIOPHARMACEUTICAL PRODUCTS AND THEIR PREPARATION PROCESS
US6358238B1 (en) 1999-09-02 2002-03-19 Scimed Life Systems, Inc. Expandable micro-catheter
JP2001079011A (en) 1999-09-14 2001-03-27 Akira Morimoto Embolization coil and its manufacture
US6277392B1 (en) 1999-09-16 2001-08-21 Carbon Medical Technologies, Inc. Tissue injectable composition
US6602261B2 (en) 1999-10-04 2003-08-05 Microvention, Inc. Filamentous embolic device with expansile elements
US6238403B1 (en) 1999-10-04 2001-05-29 Microvention, Inc. Filamentous embolic device with expansible elements
KR100335866B1 (en) 2000-01-06 2002-05-10 박호군 Microspheric Embolic Materials Having Duel Structure of Poly(Vinyl Acetate) Core/Poly(Vinyl Alcohol) Shell, and Method for Preparing The Same
JP2001201815A (en) * 2000-01-17 2001-07-27 Konica Corp Heat developable photosensitive material
US6306419B1 (en) 2000-02-23 2001-10-23 Aegis Biosciences, Llc Medical uses of styrene sulfonate polymers
CA2401879A1 (en) 2000-03-06 2001-09-13 Stephan Mangin Embolic agents visible under ultrasound
US6676971B2 (en) 2000-03-13 2004-01-13 Biocure, Inc. Embolic compositions
US6652883B2 (en) 2000-03-13 2003-11-25 Biocure, Inc. Tissue bulking and coating compositions
US6998137B2 (en) 2000-04-07 2006-02-14 Macromed, Inc. Proteins deposited onto sparingly soluble biocompatible particles for controlled protein release into a biological environment from a polymer matrix
AUPQ677200A0 (en) 2000-04-07 2000-05-11 Dunstan, David Edwin Production method
US6423332B1 (en) 2000-05-26 2002-07-23 Ethicon, Inc. Method and composition for deforming soft tissues
DE10026620A1 (en) 2000-05-29 2002-03-07 Gerhard Quelle Biocompatible material for cell and tissue implantation, useful e.g. for drug release or cosmetic tissue augmentation, consisting of spherical particles having (semi-)permeable or porous outer shell and internal cavity
US6355275B1 (en) 2000-06-23 2002-03-12 Carbon Medical Technologies, Inc. Embolization using carbon coated microparticles
JP2002017848A (en) 2000-07-12 2002-01-22 Terumo Corp Intravitally injectable particulate and method for preparing the same
WO2002011696A2 (en) 2000-08-08 2002-02-14 Ev & M Active tissue augmentation materials and method
EP1355630B1 (en) 2000-08-15 2009-11-25 The Board Of Trustees Of The University Of Illinois Method of forming microparticles
US6394965B1 (en) 2000-08-15 2002-05-28 Carbon Medical Technologies, Inc. Tissue marking using biocompatible microparticles
AU2001294772A1 (en) 2000-09-27 2002-04-08 Microtek Laboratories, Inc. Macrocapsules containing microencapsulated phase change materials
AUPR098300A0 (en) 2000-10-25 2000-11-16 Sirtex Medical Limited Polymer based radionuclide containing microspheres
AUPR098200A0 (en) 2000-10-25 2000-11-16 Sirtex Medical Limited Production of low density radionuclide containing microspheres
ES2326209T3 (en) 2000-10-27 2009-10-05 Baxter Healthcare S.A. MICRO SPHERES PRODUCTION.
US6545097B2 (en) 2000-12-12 2003-04-08 Scimed Life Systems, Inc. Drug delivery compositions and medical devices containing block copolymer
AU2001298061A1 (en) 2000-12-13 2003-07-09 Purdue Research Foundation Microencapsulation of drugs by solvent exchange
US6632531B2 (en) 2001-02-15 2003-10-14 Rohm And Haas Company Porous particles, their aqueous dispersions, and method of preparation
US6887857B2 (en) 2001-04-27 2005-05-03 Scimed Life Systems, Inc. Microparticle protection of therapeutic agents
CA2349989A1 (en) 2001-06-07 2002-12-07 Paul J. Santerre Bioactive surface modifiers for polymers and articles made therefrom
US20030032935A1 (en) 2001-08-10 2003-02-13 Scimed Life Systems, Inc. Packages facilitating convenient mixing and delivery of liquids
CA2480632A1 (en) 2002-03-29 2003-10-09 Boston Scientific Limited Drug delivery particle
US7131997B2 (en) 2002-03-29 2006-11-07 Scimed Life Systems, Inc. Tissue treatment
WO2003084582A1 (en) 2002-03-29 2003-10-16 Boston Scientific Limited Embolization
CA2480630A1 (en) 2002-03-29 2003-10-09 Boston Scientific Limited Tissue treatment
US7218962B2 (en) 2002-03-29 2007-05-15 Boston Scientific Scimed, Inc. Magnetically enhanced injection catheter
US7462366B2 (en) 2002-03-29 2008-12-09 Boston Scientific Scimed, Inc. Drug delivery particle
US7094369B2 (en) 2002-03-29 2006-08-22 Scimed Life Systems, Inc. Processes for manufacturing polymeric microspheres
US7053134B2 (en) 2002-04-04 2006-05-30 Scimed Life Systems, Inc. Forming a chemically cross-linked particle of a desired shape and diameter
US7838699B2 (en) 2002-05-08 2010-11-23 Biosphere Medical Embolization using degradable crosslinked hydrogels
JP4055481B2 (en) * 2002-06-12 2008-03-05 コニカミノルタホールディングス株式会社 Dry imaging materials
JP4076795B2 (en) * 2002-06-12 2008-04-16 富士フイルム株式会社 Photothermographic material
JP2005535752A (en) 2002-08-09 2005-11-24 ボストン サイエンティフィック リミテッド Embolization
US20040076582A1 (en) 2002-08-30 2004-04-22 Dimatteo Kristian Agent delivery particle
US7449236B2 (en) 2002-08-09 2008-11-11 Boston Scientific Scimed, Inc. Porous polymeric particle comprising polyvinyl alcohol and having interior to surface porosity-gradient
US8012454B2 (en) 2002-08-30 2011-09-06 Boston Scientific Scimed, Inc. Embolization
US7588825B2 (en) 2002-10-23 2009-09-15 Boston Scientific Scimed, Inc. Embolic compositions
US7883490B2 (en) 2002-10-23 2011-02-08 Boston Scientific Scimed, Inc. Mixing and delivery of therapeutic compositions
JP4133214B2 (en) * 2002-10-25 2008-08-13 信越化学工業株式会社 Curable composition
US7792568B2 (en) 2003-03-17 2010-09-07 Boston Scientific Scimed, Inc. MRI-visible medical devices
US7906148B2 (en) 2003-07-31 2011-03-15 Boston Scientific Scimed, Inc. Latex medical articles for release of antimicrobial agents
US20050037047A1 (en) 2003-08-11 2005-02-17 Young-Ho Song Medical devices comprising spray dried microparticles
US7976823B2 (en) 2003-08-29 2011-07-12 Boston Scientific Scimed, Inc. Ferromagnetic particles and methods
US7901770B2 (en) 2003-11-04 2011-03-08 Boston Scientific Scimed, Inc. Embolic compositions
US7736671B2 (en) * 2004-03-02 2010-06-15 Boston Scientific Scimed, Inc. Embolization
US7311861B2 (en) * 2004-06-01 2007-12-25 Boston Scientific Scimed, Inc. Embolization

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US7736671B2 (en) 2010-06-15
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US20050196449A1 (en) 2005-09-08
US20100209522A1 (en) 2010-08-19
US20150157768A1 (en) 2015-06-11
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US8445022B2 (en) 2013-05-21
US20120282472A1 (en) 2012-11-08
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EP1742614B1 (en) 2009-05-27
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US9339591B2 (en) 2016-05-17
US8216612B2 (en) 2012-07-10

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