WO2005080477A3 - Systems and methods for controlling and forming polymer gels - Google Patents

Systems and methods for controlling and forming polymer gels Download PDF

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Publication number
WO2005080477A3
WO2005080477A3 PCT/US2005/004773 US2005004773W WO2005080477A3 WO 2005080477 A3 WO2005080477 A3 WO 2005080477A3 US 2005004773 W US2005004773 W US 2005004773W WO 2005080477 A3 WO2005080477 A3 WO 2005080477A3
Authority
WO
WIPO (PCT)
Prior art keywords
vinyl polymer
gellant
solution
gelation
polymer solution
Prior art date
Application number
PCT/US2005/004773
Other languages
French (fr)
Other versions
WO2005080477A2 (en
Inventor
Jeffrey W Ruberti
Gavin J C Braithwaite
Original Assignee
Cambridge Polymer Group Inc
Jeffrey W Ruberti
Gavin J C Braithwaite
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/US2004/003135 external-priority patent/WO2005017000A1/en
Priority claimed from US10/771,852 external-priority patent/US7485670B2/en
Application filed by Cambridge Polymer Group Inc, Jeffrey W Ruberti, Gavin J C Braithwaite filed Critical Cambridge Polymer Group Inc
Priority to US10/597,688 priority Critical patent/US20100063174A1/en
Priority to CA002555226A priority patent/CA2555226A1/en
Priority to JP2006552378A priority patent/JP2007520622A/en
Priority to EP05751023A priority patent/EP1713851A2/en
Priority to AU2005214358A priority patent/AU2005214358A1/en
Publication of WO2005080477A2 publication Critical patent/WO2005080477A2/en
Publication of WO2005080477A3 publication Critical patent/WO2005080477A3/en

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14Macromolecular materials
    • A61L27/26Mixtures of macromolecular compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14Macromolecular materials
    • A61L27/16Macromolecular materials obtained by reactions only involving carbon-to-carbon unsaturated bonds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/52Hydrogels or hydrocolloids
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08JWORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J3/00Processes of treating or compounding macromolecular substances
    • C08J3/02Making solutions, dispersions, lattices or gels by other methods than by solution, emulsion or suspension polymerisation techniques
    • C08J3/03Making solutions, dispersions, lattices or gels by other methods than by solution, emulsion or suspension polymerisation techniques in aqueous media
    • C08J3/075Macromolecular gels
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08JWORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J2329/00Characterised by the use of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by an alcohol, ether, aldehydo, ketonic, acetal, or ketal radical; Hydrolysed polymers of esters of unsaturated alcohols with saturated carboxylic acids; Derivatives of such polymer
    • C08J2329/02Homopolymers or copolymers of unsaturated alcohols
    • C08J2329/04Polyvinyl alcohol; Partially hydrolysed homopolymers or copolymers of esters of unsaturated alcohols with saturated carboxylic acids

Abstract

In preferred embodiments, the present invention provides methods of controllably making a vinyl polymer hydrogel having desired physical properties without chemical cross links or radiation. The gelation process is modulated by controlling, for example, the temperature of a resultant vinyl polymer mixture having a gellant or using active ingredients provided in an inactive gellant complex. In accordance with a preferred embodiment, the method of manufacturing a vinyl polymer hydrogel includes the steps of providing a vinyl polymer solution comprising a vinyl polymer dissolved in a first solvent; heating the vinyl polymer solution to a temperature elevated above the melting point of the physical associations of the vinyl polymer, mixing the vinyl polymer solution with a gellant, wherein the resulting mixture has a higher Flory interaction parameter than the vinyl polymer solution; inducing gelation of the mixture of vinyl polymer solution and gellant; and controlling the gelation rate to form a viscoelastic solution, wherein workability is maintained for a predetermined period, thereby making a vinyl polymer hydrogel having the desired physical property. In further preferred embodiments, the present invention provides physically crosslinked hydrogels produced by controlled gelation of viscoelastic solution wherein workability is maintained for a predetermined period. In another aspect, the present invention provides kits for use in repairing intervertebral disks or articulated joints including a dispenser and single use containers housing components that form the vinyl polymer hydrogel.
PCT/US2005/004773 2004-02-04 2005-02-04 Systems and methods for controlling and forming polymer gels WO2005080477A2 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
US10/597,688 US20100063174A1 (en) 2004-02-04 2005-02-04 Systems and methods for controlling and forming polymer gels
CA002555226A CA2555226A1 (en) 2004-02-04 2005-02-04 Systems and methods for controlling and forming polymer gels
JP2006552378A JP2007520622A (en) 2004-02-04 2005-02-04 Systems and methods for controlling and forming polymer gels
EP05751023A EP1713851A2 (en) 2004-02-04 2005-02-04 Systems and methods for controlling and forming polymer gels
AU2005214358A AU2005214358A1 (en) 2004-02-04 2005-02-04 Systems and methods for controlling and forming polymer gels

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
PCT/US2004/003135 WO2005017000A1 (en) 2003-07-31 2004-02-04 Systems and methods for controlling and forming polymer gels
USPCT/US04/03135 2004-02-04
US10/771,852 2004-02-04
US10/771,852 US7485670B2 (en) 2002-08-02 2004-02-04 Systems and methods for controlling and forming polymer gels

Publications (2)

Publication Number Publication Date
WO2005080477A2 WO2005080477A2 (en) 2005-09-01
WO2005080477A3 true WO2005080477A3 (en) 2005-11-10

Family

ID=56290659

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2005/004773 WO2005080477A2 (en) 2004-02-04 2005-02-04 Systems and methods for controlling and forming polymer gels

Country Status (5)

Country Link
EP (1) EP1713851A2 (en)
JP (1) JP2007520622A (en)
AU (1) AU2005214358A1 (en)
CA (1) CA2555226A1 (en)
WO (1) WO2005080477A2 (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2607393A1 (en) * 2005-05-18 2006-11-23 The General Hospital Corporation Dba Massachusetts General Hospital Hydrogels and hydrogel particles
EP1800694A1 (en) * 2005-12-23 2007-06-27 Applied NanoSystems B.V. Controlled release gels
US20080097229A1 (en) * 2006-08-29 2008-04-24 Josee Roy Hygroscopic treatment for degenerating discs
BRPI0910843A2 (en) * 2008-05-27 2019-08-27 Univ Drexel hydrogel transition phase
US20230320860A1 (en) * 2009-07-10 2023-10-12 Peter Mats Forsell Hip Joint Method
KR101420837B1 (en) * 2012-10-09 2014-07-17 재단법인대구경북과학기술원 Hydrogel and producing method of the same
KR101709016B1 (en) * 2015-09-21 2017-02-21 연세대학교 원주산학협력단 Preparation method for polymer solution from polymer gel using microwave
CN113185823B (en) * 2021-05-27 2022-12-20 中国科学院长春应用化学研究所 Polycaprolactone composite material and preparation method thereof

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6231605B1 (en) * 1997-05-05 2001-05-15 Restore Therapeutics Poly(vinyl alcohol) hydrogel
US20040092653A1 (en) * 2002-08-02 2004-05-13 Cambridge Polymer Group, Inc. Systems and methods for controlling and forming polymer gels
US20040171740A1 (en) * 2002-08-02 2004-09-02 Cambridge Polymer Group, Inc. Systems and methods for controlling and forming polymer gels

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH05168909A (en) * 1991-03-08 1993-07-02 Terumo Corp Hydrogel with high water content and production thereof
JPH05317689A (en) * 1992-05-20 1993-12-03 Terumo Corp Highly elastic water-containing gel and its production
WO1999015211A1 (en) * 1997-09-19 1999-04-01 Reprogenesis, Inc. Improved hydrogel for tissue engineering
DE19827552C1 (en) * 1998-06-20 2000-03-02 Vorlop Klaus Dieter Process for producing a gel from polyvinyl alcohol and mechanically highly stable gel produced by the process
EP1648955A1 (en) * 2003-07-31 2006-04-26 Cambridge Polymer Group Systems and methods for controlling and forming polymer gels

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6231605B1 (en) * 1997-05-05 2001-05-15 Restore Therapeutics Poly(vinyl alcohol) hydrogel
US20040092653A1 (en) * 2002-08-02 2004-05-13 Cambridge Polymer Group, Inc. Systems and methods for controlling and forming polymer gels
US20040171740A1 (en) * 2002-08-02 2004-09-02 Cambridge Polymer Group, Inc. Systems and methods for controlling and forming polymer gels

Also Published As

Publication number Publication date
CA2555226A1 (en) 2005-09-01
JP2007520622A (en) 2007-07-26
EP1713851A2 (en) 2006-10-25
AU2005214358A1 (en) 2005-09-01
WO2005080477A2 (en) 2005-09-01

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