WO2005016558A3 - Methods for accelerated release of material from a reservoir device - Google Patents

Methods for accelerated release of material from a reservoir device Download PDF

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Publication number
WO2005016558A3
WO2005016558A3 PCT/US2004/025110 US2004025110W WO2005016558A3 WO 2005016558 A3 WO2005016558 A3 WO 2005016558A3 US 2004025110 W US2004025110 W US 2004025110W WO 2005016558 A3 WO2005016558 A3 WO 2005016558A3
Authority
WO
WIPO (PCT)
Prior art keywords
reservoir
methods
contents
accelerating
outlet
Prior art date
Application number
PCT/US2004/025110
Other languages
French (fr)
Other versions
WO2005016558A2 (en
Inventor
Jonathan R Coppeta
John M Maloney
Benjamin F Polito
Jr John T Santini
Jr Norman F Sheppard
Scott A Uhland
Original Assignee
Microchips Inc
Jonathan R Coppeta
John M Maloney
Benjamin F Polito
Jr John T Santini
Jr Norman F Sheppard
Scott A Uhland
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Microchips Inc, Jonathan R Coppeta, John M Maloney, Benjamin F Polito, Jr John T Santini, Jr Norman F Sheppard, Scott A Uhland filed Critical Microchips Inc
Publication of WO2005016558A2 publication Critical patent/WO2005016558A2/en
Publication of WO2005016558A3 publication Critical patent/WO2005016558A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0097—Micromachined devices; Microelectromechanical systems [MEMS]; Devices obtained by lithographic treatment of silicon; Devices comprising chips
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
    • A61K9/0009—Galenical forms characterised by the drug release technique; Application systems commanded by energy involving or responsive to electricity, magnetism or acoustic waves; Galenical aspects of sonophoresis, iontophoresis, electroporation or electroosmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142—Pressure infusion, e.g. using pumps
    • A61M5/14244—Pressure infusion, e.g. using pumps adapted to be carried by the patient, e.g. portable on the body
    • A61M5/14276—Pressure infusion, e.g. using pumps adapted to be carried by the patient, e.g. portable on the body specially adapted for implantation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/02—General characteristics of the apparatus characterised by a particular materials
    • A61M2205/0266—Shape memory materials

Abstract

Methods and devices are provided for selective release or exposure of reservoir contents, such as a drug formulation or diagnostic reagent, sealed in a reservoir, e.g., a microreservoir. The devices comprise a substrate; one or more reservoirs located in and defined by the substrate; reservoir contents located inside the reservoirs; a reservoir cap or rupturable layer sealing an outlet of the reservoir; and means for disintegrating the reservoir cap or rupturing the rupturable layer; and means for accelerating the release of the reservoir contents from the reservoir through the outlet, or for enhancing diffusional mass transport of a material into or out of the reservoir. The means for accelerating can, for example, include a shape memory material. In a preferred embodiment, the device is adapted for implantation into a human or animal body and comprises an array of several discrete reservoir, each one being individually openable at a desired time.
PCT/US2004/025110 2003-08-04 2004-08-04 Methods for accelerated release of material from a reservoir device WO2005016558A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US49241803P 2003-08-04 2003-08-04
US60/492,418 2003-08-04

Publications (2)

Publication Number Publication Date
WO2005016558A2 WO2005016558A2 (en) 2005-02-24
WO2005016558A3 true WO2005016558A3 (en) 2005-12-29

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2004/025110 WO2005016558A2 (en) 2003-08-04 2004-08-04 Methods for accelerated release of material from a reservoir device

Country Status (2)

Country Link
US (1) US20050055014A1 (en)
WO (1) WO2005016558A2 (en)

Families Citing this family (157)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001064344A2 (en) * 2000-03-02 2001-09-07 Microchips, Inc. Microfabricated devices for the storage and selective exposure of chemicals and devices
US6682521B2 (en) * 2000-03-23 2004-01-27 Dennis N. Petrakis Temperature activated systems
JP4657577B2 (en) 2001-01-09 2011-03-23 マイクロチップス・インコーポレーテッド Flexible microchip device for ocular and other applications
US7607402B2 (en) 2001-03-23 2009-10-27 Petrakis Dennis N Temperature responsive systems
US7655001B2 (en) 2001-03-23 2010-02-02 Petrakis Dennis N Temperature responsive systems
US7445616B2 (en) * 2001-03-23 2008-11-04 Petrakis Dennis N Temperature responsive systems
US20030235538A1 (en) * 2002-04-09 2003-12-25 Boehringer Ingelheim Pharma Gmbh & Co. Kg Method for the administration of an anticholinergic by inhalation
US7476224B2 (en) * 2003-03-17 2009-01-13 Petrakis Dennis N Temperature responsive systems
US8095197B2 (en) * 2003-11-03 2012-01-10 Microchips, Inc. Medical device for sensing glucose
SE0303570L (en) * 2003-12-03 2005-06-04 Microdrug Ag Moisture-sensitive medical product
SE0303269L (en) * 2003-12-03 2005-06-04 Microdrug Ag Medical product
AU2004294889B2 (en) * 2003-12-03 2010-08-26 Boehringer Ingelheim International Gmbh Medical product containing tiotropium
US7976520B2 (en) 2004-01-12 2011-07-12 Nulens Ltd. Eye wall anchored fixtures
US8147561B2 (en) 2004-02-26 2012-04-03 Endosphere, Inc. Methods and devices to curb appetite and/or reduce food intake
US8585771B2 (en) * 2004-02-26 2013-11-19 Endosphere, Inc. Methods and devices to curb appetite and/or to reduce food intake
US7931693B2 (en) * 2004-02-26 2011-04-26 Endosphere, Inc. Method and apparatus for reducing obesity
US20080102119A1 (en) * 2006-11-01 2008-05-01 Medtronic, Inc. Osmotic pump apparatus and associated methods
CA2569375A1 (en) * 2004-06-01 2006-08-17 Microchips, Inc. Devices and methods for measuring and enhancing drug or analyte transport to/from medical implant
WO2006015299A2 (en) * 2004-07-30 2006-02-09 Microchips, Inc. Multi-reservoir device for transdermal drug delivery and sensing
JP5107041B2 (en) * 2004-09-01 2012-12-26 マイクロチップス・インコーポレーテッド Multi-cap reservoir device for controlled release or exposure of reservoir contents
US20060093646A1 (en) * 2004-10-28 2006-05-04 Cima Michael J Orthopedic and dental implant devices providing controlled drug delivery
CA2584851C (en) * 2004-11-04 2015-04-07 Microchips, Inc. Compression and cold weld sealing methods and devices
US7413846B2 (en) 2004-11-15 2008-08-19 Microchips, Inc. Fabrication methods and structures for micro-reservoir devices
US7467075B2 (en) * 2004-12-23 2008-12-16 Covidien Ag Three-dimensional finite-element code for electrosurgery and thermal ablation simulations
WO2006081279A2 (en) * 2005-01-25 2006-08-03 Microchips, Inc. Control of drug release by transient modification of local microenvironments
US9022980B2 (en) 2005-02-01 2015-05-05 Kaleo, Inc. Medical injector simulation device
US8231573B2 (en) 2005-02-01 2012-07-31 Intelliject, Inc. Medicament delivery device having an electronic circuit system
US8361026B2 (en) 2005-02-01 2013-01-29 Intelliject, Inc. Apparatus and methods for self-administration of vaccines and other medicaments
US7731686B2 (en) * 2005-02-01 2010-06-08 Intelliject, Inc. Devices, systems and methods for medicament delivery
ES2396745T3 (en) 2005-02-01 2013-02-25 Intelliject, Inc. Devices for medication administration
US8206360B2 (en) 2005-02-01 2012-06-26 Intelliject, Inc. Devices, systems and methods for medicament delivery
US8802183B2 (en) 2005-04-28 2014-08-12 Proteus Digital Health, Inc. Communication system with enhanced partial power source and method of manufacturing same
US8912908B2 (en) 2005-04-28 2014-12-16 Proteus Digital Health, Inc. Communication system with remote activation
EP3827747A1 (en) 2005-04-28 2021-06-02 Otsuka Pharmaceutical Co., Ltd. Pharma-informatics system
US8836513B2 (en) 2006-04-28 2014-09-16 Proteus Digital Health, Inc. Communication system incorporated in an ingestible product
US9198608B2 (en) 2005-04-28 2015-12-01 Proteus Digital Health, Inc. Communication system incorporated in a container
US8730031B2 (en) 2005-04-28 2014-05-20 Proteus Digital Health, Inc. Communication system using an implantable device
US20070016163A1 (en) * 2005-06-28 2007-01-18 Microchips, Inc. Medical and dental implant devices for controlled drug delivery
WO2007010900A1 (en) * 2005-07-15 2007-01-25 Transcu Ltd. Percutaneous absorption patch with application position indicating function, and iontophoresis device
JP2007037868A (en) * 2005-08-05 2007-02-15 Transcutaneous Technologies Inc Transdermal administration device and its controlling method
US20090216177A1 (en) * 2005-09-16 2009-08-27 Tti Ellebeau,Inc Catheter-type iontophoresis device
BRPI0616771A2 (en) * 2005-09-30 2011-06-28 Tti Ellebeau Inc iontophoresis device to release multiple active agents for biological interfaces
WO2007042961A2 (en) * 2005-10-11 2007-04-19 Koninklijke Philips Electronics N.V. Device for controlled release of chemical molecules
US7817030B2 (en) 2005-11-09 2010-10-19 Invention Science Fund 1, Llc Remote controller for in situ reaction device
US8083710B2 (en) * 2006-03-09 2011-12-27 The Invention Science Fund I, Llc Acoustically controlled substance delivery device
US8998886B2 (en) * 2005-12-13 2015-04-07 The Invention Science Fund I, Llc Remote control of osmotic pump device
US8936590B2 (en) * 2005-11-09 2015-01-20 The Invention Science Fund I, Llc Acoustically controlled reaction device
US7942867B2 (en) * 2005-11-09 2011-05-17 The Invention Science Fund I, Llc Remotely controlled substance delivery device
US8273071B2 (en) * 2006-01-18 2012-09-25 The Invention Science Fund I, Llc Remote controller for substance delivery system
US9067047B2 (en) * 2005-11-09 2015-06-30 The Invention Science Fund I, Llc Injectable controlled release fluid delivery system
US8992511B2 (en) 2005-11-09 2015-03-31 The Invention Science Fund I, Llc Acoustically controlled substance delivery device
US20080033338A1 (en) * 2005-12-28 2008-02-07 Smith Gregory A Electroosmotic pump apparatus and method to deliver active agents to biological interfaces
US7848801B2 (en) 2005-12-30 2010-12-07 Tti Ellebeau, Inc. Iontophoretic systems, devices, and methods of delivery of active agents to biological interface
JP4881959B2 (en) * 2006-01-17 2012-02-22 ニューレンズ・リミテッド Intraocular drug dispenser
US20080140057A1 (en) 2006-03-09 2008-06-12 Searete Llc, A Limited Liability Corporation Of State Of The Delaware Injectable controlled release fluid delivery system
WO2007123707A1 (en) * 2006-03-30 2007-11-01 Tti Ellebeau, Inc. Controlled release membrane and methods of use
US20070253960A1 (en) * 2006-04-28 2007-11-01 Josee Roy Pharmaceutical removal of vascular extensions from a degenerating disc
JP2009544338A (en) * 2006-05-02 2009-12-17 プロテウス バイオメディカル インコーポレイテッド Treatment regimen customized to the patient
US9060835B2 (en) 2006-05-26 2015-06-23 Endosphere, Inc. Conformationally-stabilized intraluminal device for medical applications
US7803148B2 (en) * 2006-06-09 2010-09-28 Neurosystec Corporation Flow-induced delivery from a drug mass
EP1867990A1 (en) * 2006-06-14 2007-12-19 Koninklijke Philips Electronics N.V. Sensitive assay through amplification of a label signal
CA2655164A1 (en) * 2006-07-05 2008-01-10 Tti Ellebeau, Inc. Delivery device having self-assembling dendritic polymers and method of use thereof
US20080020037A1 (en) * 2006-07-11 2008-01-24 Robertson Timothy L Acoustic Pharma-Informatics System
EP2043728A2 (en) * 2006-07-11 2009-04-08 Microchips, Inc. Multi-reservoir pump device for dialysis, biosensing, or delivery of substances
EP2049080A2 (en) * 2006-07-27 2009-04-22 Koninklijke Philips Electronics N.V. A drug delivery system with thermoswitchable membranes
US20080022927A1 (en) 2006-07-28 2008-01-31 Sean Xiao-An Zhang Microfluidic device for controlled movement of material
KR101611240B1 (en) 2006-10-25 2016-04-11 프로테우스 디지털 헬스, 인코포레이티드 Controlled activation ingestible identifier
WO2008063626A2 (en) 2006-11-20 2008-05-29 Proteus Biomedical, Inc. Active signal processing personal health signal receivers
WO2008091838A2 (en) 2007-01-22 2008-07-31 Intelliject, Inc. Medical injector with compliance tracking and monitoring
MY165532A (en) 2007-02-01 2018-04-02 Proteus Digital Health Inc Ingestible event marker systems
EP2111661B1 (en) 2007-02-14 2017-04-12 Proteus Digital Health, Inc. In-body power source having high surface area electrode
WO2008112577A1 (en) 2007-03-09 2008-09-18 Proteus Biomedical, Inc. In-body device having a multi-directional transmitter
EP2063771A1 (en) 2007-03-09 2009-06-03 Proteus Biomedical, Inc. In-body device having a deployable antenna
US8703168B2 (en) * 2007-04-25 2014-04-22 Boston Scientific Scimed, Inc. Medical devices for releasing therapeutic agent and methods of making the same
US8540632B2 (en) 2007-05-24 2013-09-24 Proteus Digital Health, Inc. Low profile antenna for in body device
DE102007032688A1 (en) * 2007-07-13 2009-01-22 Biotronik Vi Patent Ag Implant and system of an implant and an excitation device
US20110137227A1 (en) * 2007-07-16 2011-06-09 Mckinley James T Methods and devices for delivering or delaying lipids within a duodenum
US8845751B2 (en) * 2007-09-21 2014-09-30 Waldemar Link Gmbh & Co. Kg Endoprosthesis component
US20090081272A1 (en) * 2007-09-24 2009-03-26 John Clarke Medical devices having a metal particulate composition for controlled diffusion
EP4011289A1 (en) 2007-09-25 2022-06-15 Otsuka Pharmaceutical Co., Ltd. In-body device with virtual dipole signal amplification
US20090135886A1 (en) 2007-11-27 2009-05-28 Proteus Biomedical, Inc. Transbody communication systems employing communication channels
US20100298808A1 (en) * 2007-11-28 2010-11-25 Janisys Limited Method and a delivery device for administering an active substance to a subject
US20090139722A1 (en) * 2007-11-30 2009-06-04 Baker Hughes Incorporated Capillary actuator device
JP2011513865A (en) 2008-03-05 2011-04-28 プロテウス バイオメディカル インコーポレイテッド Multi-mode communication ingestible event marker and system and method of using the same
US20090259217A1 (en) * 2008-04-09 2009-10-15 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Methods and systems associated with delivery of one or more agents to an individual
US20090259214A1 (en) * 2008-04-09 2009-10-15 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Agent delivery device
USD994111S1 (en) 2008-05-12 2023-08-01 Kaleo, Inc. Medicament delivery device cover
WO2010005877A2 (en) 2008-07-08 2010-01-14 Proteus Biomedical, Inc. Ingestible event marker data framework
KR101214453B1 (en) 2008-08-13 2012-12-24 프로테우스 디지털 헬스, 인코포레이티드 Ingestible circuitry
CN102209573A (en) * 2008-09-10 2011-10-05 透皮株式会社 Apparatus and method to dispense hpc-based viscous liquids into porous substrates, e.g., continuous web-based process
US9659423B2 (en) 2008-12-15 2017-05-23 Proteus Digital Health, Inc. Personal authentication apparatus system and method
WO2013012869A1 (en) 2011-07-21 2013-01-24 Proteus Digital Health, Inc. Mobile communication device, system, and method
US9439566B2 (en) 2008-12-15 2016-09-13 Proteus Digital Health, Inc. Re-wearable wireless device
WO2010080575A2 (en) 2008-12-18 2010-07-15 Michal Konstantino Method and apparatus for transport of substances into body tissue
CN102341031A (en) 2009-01-06 2012-02-01 普罗秋斯生物医学公司 Ingestion-related biofeedback and personalized medical therapy method and system
EP3395333A1 (en) 2009-01-06 2018-10-31 Proteus Digital Health, Inc. Pharmaceutical dosages delivery system
US8126736B2 (en) 2009-01-23 2012-02-28 Warsaw Orthopedic, Inc. Methods and systems for diagnosing, treating, or tracking spinal disorders
US8685093B2 (en) 2009-01-23 2014-04-01 Warsaw Orthopedic, Inc. Methods and systems for diagnosing, treating, or tracking spinal disorders
GB2480965B (en) 2009-03-25 2014-10-08 Proteus Digital Health Inc Probablistic pharmacokinetic and pharmacodynamic modeling
MX2011011506A (en) 2009-04-28 2012-05-08 Proteus Biomedical Inc Highly reliable ingestible event markers and methods for using the same.
US9149423B2 (en) 2009-05-12 2015-10-06 Proteus Digital Health, Inc. Ingestible event markers comprising an ingestible component
TWI517050B (en) 2009-11-04 2016-01-11 普羅托斯數位健康公司 System for supply chain management
UA109424C2 (en) 2009-12-02 2015-08-25 PHARMACEUTICAL PRODUCT, PHARMACEUTICAL TABLE WITH ELECTRONIC MARKER AND METHOD OF MANUFACTURING PHARMACEUTICAL TABLETS
AU2011210648B2 (en) 2010-02-01 2014-10-16 Otsuka Pharmaceutical Co., Ltd. Data gathering system
US8702682B2 (en) * 2010-02-05 2014-04-22 Boston Scientific Scimed, Inc. Medical devices employing piezoelectric materials for delivery of therapeutic agents
WO2011127252A2 (en) 2010-04-07 2011-10-13 Proteus Biomedical, Inc. Miniature ingestible device
TWI557672B (en) 2010-05-19 2016-11-11 波提亞斯數位康健公司 Computer system and computer-implemented method to track medication from manufacturer to a patient, apparatus and method for confirming delivery of medication to a patient, patient interface device
EP2642983A4 (en) 2010-11-22 2014-03-12 Proteus Digital Health Inc Ingestible device with pharmaceutical product
US8939943B2 (en) 2011-01-26 2015-01-27 Kaleo, Inc. Medicament delivery device for administration of opioid antagonists including formulations for naloxone
US8627816B2 (en) 2011-02-28 2014-01-14 Intelliject, Inc. Medicament delivery device for administration of opioid antagonists including formulations for naloxone
US9439599B2 (en) 2011-03-11 2016-09-13 Proteus Digital Health, Inc. Wearable personal body associated device with various physical configurations
US9756874B2 (en) 2011-07-11 2017-09-12 Proteus Digital Health, Inc. Masticable ingestible product and communication system therefor
WO2015112603A1 (en) 2014-01-21 2015-07-30 Proteus Digital Health, Inc. Masticable ingestible product and communication system therefor
US9235683B2 (en) 2011-11-09 2016-01-12 Proteus Digital Health, Inc. Apparatus, system, and method for managing adherence to a regimen
TW201424689A (en) 2012-07-23 2014-07-01 Proteus Digital Health Inc Techniques for manufacturing ingestible event markers comprising an ingestible component
US9268909B2 (en) 2012-10-18 2016-02-23 Proteus Digital Health, Inc. Apparatus, system, and method to adaptively optimize power dissipation and broadcast power in a power source for a communication device
WO2014106096A1 (en) 2012-12-27 2014-07-03 Kaleo, Inc. Devices, systems and methods for locating and interacting with medicament delivery systems
US11149123B2 (en) 2013-01-29 2021-10-19 Otsuka Pharmaceutical Co., Ltd. Highly-swellable polymeric films and compositions comprising the same
CN104968268A (en) 2013-02-06 2015-10-07 加州理工学院 Miniaturized implantable electrochemical sensor devices
JP6498177B2 (en) 2013-03-15 2019-04-10 プロテウス デジタル ヘルス， インコーポレイテッド Identity authentication system and method
US10175376B2 (en) 2013-03-15 2019-01-08 Proteus Digital Health, Inc. Metal detector apparatus, system, and method
EP2991719A4 (en) * 2013-05-02 2017-01-11 Elwha LLC Implantable device for manipulating immune cells
US20140330257A1 (en) * 2013-05-02 2014-11-06 Elwha Llc Implantable Device for Manipulating Immune Cells
JP6511439B2 (en) 2013-06-04 2019-05-15 プロテウス デジタル ヘルス， インコーポレイテッド Systems, devices, and methods for data collection and outcome assessment
KR101821572B1 (en) * 2013-06-17 2018-01-26 주식회사 주빅 Painless and Patchless Shooting Microstructures
US9796576B2 (en) 2013-08-30 2017-10-24 Proteus Digital Health, Inc. Container with electronically controlled interlock
MX356850B (en) 2013-09-20 2018-06-15 Proteus Digital Health Inc Methods, devices and systems for receiving and decoding a signal in the presence of noise using slices and warping.
US9577864B2 (en) 2013-09-24 2017-02-21 Proteus Digital Health, Inc. Method and apparatus for use with received electromagnetic signal at a frequency not known exactly in advance
EP3049145B1 (en) * 2013-09-26 2020-06-17 Progenity, Inc. Delivery capsule with threshold release
US10084880B2 (en) 2013-11-04 2018-09-25 Proteus Digital Health, Inc. Social media networking based on physiologic information
EP3145561A1 (en) 2014-05-20 2017-03-29 Cequr SA Medicine delivery device with restricted access filling port
US9517307B2 (en) 2014-07-18 2016-12-13 Kaleo, Inc. Devices and methods for delivering opioid antagonists including formulations for naloxone
US9937124B2 (en) 2014-09-11 2018-04-10 International Business Machines Corporation Microchip substance delivery devices having low-power electromechanical release mechanisms
DE102015205536B4 (en) * 2015-03-26 2017-02-02 Siemens Healthcare Gmbh Dosing device for dosing a substance
US11051543B2 (en) 2015-07-21 2021-07-06 Otsuka Pharmaceutical Co. Ltd. Alginate on adhesive bilayer laminate film
US10368788B2 (en) * 2015-07-23 2019-08-06 California Institute Of Technology System and methods for wireless drug delivery on command
US20170064924A1 (en) * 2015-09-05 2017-03-09 Alison A. Stout Animal Olfaction Training Apparatus and Method
US10881788B2 (en) 2015-10-30 2021-01-05 International Business Machines Corporation Delivery device including reactive material for programmable discrete delivery of a substance
CN109843149B (en) 2016-07-22 2020-07-07 普罗秋斯数字健康公司 Electromagnetic sensing and detection of ingestible event markers
US11268927B2 (en) 2016-08-30 2022-03-08 Analog Devices International Unlimited Company Electrochemical sensor, and a method of forming an electrochemical sensor
US10620151B2 (en) 2016-08-30 2020-04-14 Analog Devices Global Electrochemical sensor, and a method of forming an electrochemical sensor
KR101849467B1 (en) * 2016-09-26 2018-04-18 주식회사 씨유메디칼시스템 Electrode Assembly for Wearable Automated External Defibrillator
MY197115A (en) * 2016-10-17 2023-05-26 Micromed Co Ltd Micro delivery device
JP2019535377A (en) 2016-10-26 2019-12-12 プロテウス デジタル ヘルス， インコーポレイテッド Method for producing capsules with ingestible event markers
WO2018136413A2 (en) 2017-01-17 2018-07-26 Kaleo, Inc. Medicament delivery devices with wireless connectivity and event detection
US10864358B2 (en) * 2017-05-02 2020-12-15 Bernard Fryshman Induction heating systems
US11541015B2 (en) 2017-05-17 2023-01-03 Massachusetts Institute Of Technology Self-righting systems, methods, and related components
IL301683A (en) 2017-05-17 2023-05-01 Massachusetts Inst Technology Self-righting systems and related components and methods
US11022579B2 (en) 2018-02-05 2021-06-01 Analog Devices International Unlimited Company Retaining cap
WO2019222570A1 (en) 2018-05-17 2019-11-21 Massachusetts Institute Of Technology Systems for electrical stimulation
WO2020018433A1 (en) 2018-07-16 2020-01-23 Kaleo, Inc. Medicament delivery devices with wireless connectivity and compliance detection
US11311670B2 (en) * 2018-10-12 2022-04-26 Flex Ltd Automatic injection device having a passive drive system with a shape memory spring
US20210402161A1 (en) * 2018-11-02 2021-12-30 Bionaut Labs Ltd. Magnetomechanic triggering ofpayload release from miniaturized devices
WO2020160399A1 (en) 2019-02-01 2020-08-06 Massachusetts Institute Of Technology Systems and methods for liquid injection
CN114728152A (en) * 2019-11-01 2022-07-08 达瑞微芯片生物技术公司 Two-stage microchip drug delivery device and method
US11541216B2 (en) 2019-11-21 2023-01-03 Massachusetts Institute Of Technology Methods for manufacturing tissue interfacing components
TW202221248A (en) 2020-11-20 2022-06-01 美商伊路米納有限公司 Actuation systems and methods

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0061783A2 (en) * 1981-04-01 1982-10-06 Olympus Optical Co., Ltd. Medical capsule device
JPS58135808A (en) * 1982-02-08 1983-08-12 Funakubo Hiroyasu Capsule
US4416659A (en) * 1981-11-09 1983-11-22 Eli Lilly And Company Sustained release capsule for ruminants
US5196002A (en) * 1990-10-09 1993-03-23 University Of Utah Research Foundation Implantable drug delivery system with piston acutation
WO2002058764A1 (en) * 2001-01-27 2002-08-01 Krumme John F A drug delivery device
WO2003024355A1 (en) * 2001-09-20 2003-03-27 Ashmont Holdings Limited Intraruminal device

Family Cites Families (73)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3692027A (en) * 1971-04-23 1972-09-19 Everett H Ellinwood Jr Implanted medication dispensing device and method
US4177256A (en) * 1973-04-25 1979-12-04 Alza Corporation Osmotic bursting drug delivery device
US4003379A (en) * 1974-04-23 1977-01-18 Ellinwood Jr Everett H Apparatus and method for implanted self-powered medication dispensing
US4146029A (en) * 1974-04-23 1979-03-27 Ellinwood Jr Everett H Self-powered implanted programmable medication system and method
US3952741A (en) * 1975-01-09 1976-04-27 Bend Research Inc. Controlled release delivery system by an osmotic bursting mechanism
US4360019A (en) * 1979-02-28 1982-11-23 Andros Incorporated Implantable infusion device
US4856188A (en) * 1984-10-12 1989-08-15 Drug Delivery Systems Inc. Method for making disposable and/or replenishable transdermal drug applicators
US4781714A (en) * 1983-11-02 1988-11-01 Alza Corporation Dispenser for delivering thermo-responsive composition
US4585652A (en) * 1984-11-19 1986-04-29 Regents Of The University Of Minnesota Electrochemical controlled release drug delivery system
US5042975A (en) * 1986-07-25 1991-08-27 Rutgers, The State University Of New Jersey Iontotherapeutic device and process and iontotherapeutic unit dose
US4731049A (en) * 1987-01-30 1988-03-15 Ionics, Incorporated Cell for electrically controlled transdermal drug delivery
US5499979A (en) * 1987-06-25 1996-03-19 Alza Corporation Delivery system comprising kinetic forces
US5391381A (en) * 1987-06-25 1995-02-21 Alza Corporation Dispenser capable of delivering plurality of drug units
US4957494A (en) * 1987-06-25 1990-09-18 Alza Corporation Multi-layer delivery system
US4874388A (en) * 1987-06-25 1989-10-17 Alza Corporation Multi-layer delivery system
US5110597A (en) * 1987-06-25 1992-05-05 Alza Corporation Multi-unit delivery system
US5252294A (en) * 1988-06-01 1993-10-12 Messerschmitt-Bolkow-Blohm Gmbh Micromechanical structure
US5041107A (en) * 1989-10-06 1991-08-20 Cardiac Pacemakers, Inc. Electrically controllable, non-occluding, body implantable drug delivery system
US5017381A (en) * 1990-05-02 1991-05-21 Alza Corporation Multi-unit pulsatile delivery system
US5167625A (en) 1990-10-09 1992-12-01 Sarcos Group Multiple vesicle implantable drug delivery system
US5254081A (en) * 1991-02-01 1993-10-19 Empi, Inc. Multiple site drug iontophoresis electronic device and method
US5391164A (en) * 1991-05-03 1995-02-21 Giampapa; Vincent C. Subcutaneous implantable multiple-agent delivery system
US5279507A (en) * 1991-09-26 1994-01-18 Yazaki Corporation Connector for use in vehicles
WO1993009842A1 (en) * 1991-11-13 1993-05-27 Elan Corporation, Plc Drug delivery device
US5429822A (en) * 1992-03-13 1995-07-04 Cambridge Scientific, Inc. Biodegradable bursting release system
US5318557A (en) * 1992-07-13 1994-06-07 Elan Medical Technologies Limited Medication administering device
US5368588A (en) * 1993-02-26 1994-11-29 Bettinger; David S. Parenteral fluid medication reservoir pump
US5366454A (en) * 1993-03-17 1994-11-22 La Corporation De L'ecole Polytechnique Implantable medication dispensing device
US5427585A (en) * 1993-03-29 1995-06-27 Bettinger; David S. On-demand iontophoretic system
US5474527A (en) * 1993-03-29 1995-12-12 Bettinger; David S. Positive displacement transdermal system
US5368704A (en) * 1993-08-06 1994-11-29 Teknekron Corporation Micro-electrochemical valves and method
US5498255A (en) * 1993-08-17 1996-03-12 Alza Corporation Osmotic device for protracted pulsatile delivery of agent
EP1157743B1 (en) * 1993-10-28 2009-03-11 Houston Advanced Research Center Microfabricated, flowthrough porous apparatus for discrete detection of binding reactions
US5574313A (en) * 1994-10-17 1996-11-12 Litten Systems, Inc. Hermetically sealed microwave integrated circuit package with ground plane fused to package frame
US6261584B1 (en) * 1996-02-02 2001-07-17 Alza Corporation Sustained delivery of an active agent using an implantable system
US6132420A (en) * 1996-02-02 2000-10-17 Alza Corporation Osmotic delivery system and method for enhancing start-up and performance of osmotic delivery systems
DE19610293C1 (en) * 1996-03-15 1997-07-31 Fraunhofer Ges Forschung Electronically-breakable microencapsulation system for sensitive materials
US5797898A (en) 1996-07-02 1998-08-25 Massachusetts Institute Of Technology Microchip drug delivery devices
US7070590B1 (en) * 1996-07-02 2006-07-04 Massachusetts Institute Of Technology Microchip drug delivery devices
US5797204A (en) * 1996-09-27 1998-08-25 Paulos; John Calendar organizing system
CA2276462C (en) * 1996-12-31 2007-06-12 Genometrix Incorporated Multiplexed molecular analysis system apparatus and method
US6010492A (en) 1997-02-07 2000-01-04 Sarcos, Lc Apparatus for automatic administration of multiple doses of drugs
US6056734A (en) * 1997-02-07 2000-05-02 Sarcos Lc Method for automatic dosing of drugs
US5782799A (en) * 1997-02-07 1998-07-21 Sarcos, Inc. Method for automatic dosing of drugs
IL121286A0 (en) * 1997-07-11 1998-01-04 Pets N People Ltd Apparatus and methods for dispensing pet care substances
US20010025157A1 (en) * 1997-08-27 2001-09-27 Kriesell Marshall S. Implantable dispensing device for controllably dispensing medicinal fluid
US6140740A (en) * 1997-12-30 2000-10-31 Remon Medical Technologies, Ltd. Piezoelectric transducer
US6237398B1 (en) * 1997-12-30 2001-05-29 Remon Medical Technologies, Ltd. System and method for monitoring pressure, flow and constriction parameters of plumbing and blood vessels
PL342996A1 (en) 1998-02-23 2001-07-16 Mnemoscience Gmbh Shape memory polymers
HU222543B1 (en) 1998-02-23 2003-08-28 Massachusetts Institute Of Technology Biodegradable shape memory polymers
US6062461A (en) * 1998-06-03 2000-05-16 Delphi Technologies, Inc. Process for bonding micromachined wafers using solder
US6221024B1 (en) * 1998-07-20 2001-04-24 Medtronic, Inc. Implantable pressure sensor and method of fabrication
US6171850B1 (en) * 1999-03-08 2001-01-09 Caliper Technologies Corp. Integrated devices and systems for performing temperature controlled reactions and analyses
US6334859B1 (en) * 1999-07-26 2002-01-01 Zuli Holdings Ltd. Subcutaneous apparatus and subcutaneous method for treating bodily tissues with electricity or medicaments
WO2001012157A1 (en) * 1999-08-18 2001-02-22 Microchips, Inc. Thermally-activated microchip chemical delivery devices
US6375454B1 (en) * 1999-11-12 2002-04-23 Sarcos, L.C. Controllable combustion device
US6491666B1 (en) * 1999-11-17 2002-12-10 Microchips, Inc. Microfabricated devices for the delivery of molecules into a carrier fluid
AU782639B2 (en) * 1999-12-10 2005-08-18 Massachusetts Institute Of Technology Microchip devices for delivery of molecules and methods of fabrication thereof
WO2001064344A2 (en) * 2000-03-02 2001-09-07 Microchips, Inc. Microfabricated devices for the storage and selective exposure of chemicals and devices
WO2001091902A2 (en) * 2000-05-30 2001-12-06 Massachusetts Institute Of Technology Methods and devices for sealing microchip reservoir devices
EP1339312B1 (en) * 2000-10-10 2006-01-04 Microchips, Inc. Microchip reservoir devices using wireless transmission of power and data
AU2002224453A1 (en) * 2000-10-11 2002-04-22 Microchips, Inc. Microchip reservoir devices and facilitated corrosion of electrodes
JP4657577B2 (en) * 2001-01-09 2011-03-23 マイクロチップス・インコーポレーテッド Flexible microchip device for ocular and other applications
AU2002326304A1 (en) * 2001-05-31 2002-12-16 Massachusetts Institute Of Technology Microchip devices with improved reservoir opening
EP1399135B1 (en) * 2001-06-28 2004-12-29 Microchips, Inc. Methods for hermetically sealing microchip reservoir devices
US6663615B1 (en) * 2001-09-04 2003-12-16 The Ohio State University Dual stage microvalve and method of use
US7510551B2 (en) * 2002-08-16 2009-03-31 Microchips, Inc. Controlled release device and method using electrothermal ablation
US6890300B2 (en) * 2002-08-27 2005-05-10 Board Of Trustees Of Michigan State University Implantable microscale pressure sensor system for pressure monitoring and management
AU2003278881A1 (en) * 2002-09-23 2004-04-08 Microchips, Inc. Micro-reservoir osmotic release systems and microtube array device
ATE458534T1 (en) * 2002-10-04 2010-03-15 Microchips Inc MEDICAL DEVICE FOR CONTROLLED DRUG ADMINISTRATION AND CARDIAC MONITORING AND/OR HEART STIMULATION
US7599737B2 (en) * 2002-10-04 2009-10-06 Microchips, Inc. Medical device for neural stimulation and controlled drug delivery
WO2005010240A2 (en) * 2003-07-17 2005-02-03 Microchips, Inc. Low temperature methods for hermetically sealing reservoir devices
US8095197B2 (en) * 2003-11-03 2012-01-10 Microchips, Inc. Medical device for sensing glucose

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0061783A2 (en) * 1981-04-01 1982-10-06 Olympus Optical Co., Ltd. Medical capsule device
US4416659A (en) * 1981-11-09 1983-11-22 Eli Lilly And Company Sustained release capsule for ruminants
JPS58135808A (en) * 1982-02-08 1983-08-12 Funakubo Hiroyasu Capsule
US5196002A (en) * 1990-10-09 1993-03-23 University Of Utah Research Foundation Implantable drug delivery system with piston acutation
WO2002058764A1 (en) * 2001-01-27 2002-08-01 Krumme John F A drug delivery device
WO2002058765A1 (en) * 2001-01-27 2002-08-01 Krumme John F A drug delivery device
WO2003024355A1 (en) * 2001-09-20 2003-03-27 Ashmont Holdings Limited Intraruminal device

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
DATABASE WPI Section Ch Week 198338, Derwent World Patents Index; Class A96, AN 1983-767939, XP002337999 *
PEIRS J ET AL: "An implantable drug-delivery system based on shape memory alloy micro-actuation", SENSORS AND ACTUATORS A, ELSEVIER SEQUOIA S.A., LAUSANNE, CH, vol. 60, no. 1-3, May 1997 (1997-05-01), pages 455 - 462, XP004089112, ISSN: 0924-4247 *

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