WO2004040972A3 - Radioisotope-associated polymeric hydrogel microspheres and methods for producing and using the same - Google Patents

Radioisotope-associated polymeric hydrogel microspheres and methods for producing and using the same Download PDF

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Publication number
WO2004040972A3
WO2004040972A3 PCT/US2003/033140 US0333140W WO2004040972A3 WO 2004040972 A3 WO2004040972 A3 WO 2004040972A3 US 0333140 W US0333140 W US 0333140W WO 2004040972 A3 WO2004040972 A3 WO 2004040972A3
Authority
WO
WIPO (PCT)
Prior art keywords
producing
microparticles
methods
radioisotope
same
Prior art date
Application number
PCT/US2003/033140
Other languages
French (fr)
Other versions
WO2004040972A2 (en
Inventor
James A Krom
Original Assignee
Biosphere Medical
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biosphere Medical filed Critical Biosphere Medical
Priority to CA002507404A priority Critical patent/CA2507404A1/en
Priority to AU2003285905A priority patent/AU2003285905A1/en
Priority to EP03779133A priority patent/EP1578455A4/en
Publication of WO2004040972A2 publication Critical patent/WO2004040972A2/en
Publication of WO2004040972A3 publication Critical patent/WO2004040972A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/12—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes, characterized by a special physical form, e.g. emulsions, dispersions, microcapsules
    • A61K51/1241—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes, characterized by a special physical form, e.g. emulsions, dispersions, microcapsules particles, powders, lyophilizates, adsorbates, e.g. polymers or resins for adsorption or ion-exchange resins
    • A61K51/1255—Granulates, agglomerates, microspheres
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/12—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes, characterized by a special physical form, e.g. emulsions, dispersions, microcapsules
    • A61K51/1213—Semi-solid forms, gels, hydrogels, ointments, fats and waxes that are solid at room temperature
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1635—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1658—Proteins, e.g. albumin, gelatin

Abstract

The present invention relates to polymeric materials that are labeled with colloidal metals, preferably colloidal gold, to processes for producing the labeled polymeric material, and to methods of using the materials in prophylactic, therapeutic and cosmetic applications. Specifically, the invention relates to porous injectable and implantable microparticles, preferably microspheres, that are associated with radioactive colloidal metals such that the microparticles are visible or detectable under regular light, by radiological and/or magnetic resonance imaging techniques, or both. The microparticles having radioactive colloidal metals are particularly useful for embolization, radiation therapy, drug delivery, gene therapy, and other prophylactic or therapeutic medical applications.
PCT/US2003/033140 2002-11-04 2003-10-17 Radioisotope-associated polymeric hydrogel microspheres and methods for producing and using the same WO2004040972A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
CA002507404A CA2507404A1 (en) 2002-11-04 2003-10-17 Radioisotope-associated polymeric hydrogel microspheres and methods for producing and using the same
AU2003285905A AU2003285905A1 (en) 2002-11-04 2003-10-17 Radioisotope-associated polymeric hydrogel microspheres and methods for producing and using the same
EP03779133A EP1578455A4 (en) 2002-11-04 2003-10-17 Radioisotope-associated polymeric hydrogel microspheres and methods for producing and using the same

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US42354702P 2002-11-04 2002-11-04
US60/423,547 2002-11-04

Publications (2)

Publication Number Publication Date
WO2004040972A2 WO2004040972A2 (en) 2004-05-21
WO2004040972A3 true WO2004040972A3 (en) 2004-10-14

Family

ID=32312672

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2003/033140 WO2004040972A2 (en) 2002-11-04 2003-10-17 Radioisotope-associated polymeric hydrogel microspheres and methods for producing and using the same

Country Status (4)

Country Link
EP (1) EP1578455A4 (en)
AU (1) AU2003285905A1 (en)
CA (1) CA2507404A1 (en)
WO (1) WO2004040972A2 (en)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7727555B2 (en) 2005-03-02 2010-06-01 Boston Scientific Scimed, Inc. Particles
US7964123B2 (en) 2004-06-01 2011-06-21 Boston Scientific Scimed, Inc. Embolization
US8430105B2 (en) 2005-04-28 2013-04-30 Boston Scientific Scimed, Inc. Tissue-treatment methods
US9463426B2 (en) 2005-06-24 2016-10-11 Boston Scientific Scimed, Inc. Methods and systems for coating particles

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060067883A1 (en) * 2004-09-24 2006-03-30 Biosphere Medical, Inc. Microspheres capable of binding radioisotopes, optionally comprising metallic microparticles, and methods of use thereof
CN101137347A (en) * 2004-11-16 2008-03-05 列日大学 Active substance delivery system comprising a hydrogel atrix and microcarriers
WO2006063418A2 (en) * 2004-12-17 2006-06-22 Facultes Universitaires Notre-Dame De La Paix Nanostructure radioactif
US20070141727A1 (en) * 2005-12-15 2007-06-21 Kimberly-Clark Worldwide, Inc. Luminescent metallic cluster particles and uses thereof
WO2009046281A2 (en) * 2007-10-05 2009-04-09 Boston Scientific Scimed, Inc. Injectable particles
CN105263477B (en) 2013-03-13 2019-01-15 生物领域医疗公司 Composition and correlation technique for radioactive isotope combination particle
EP2923712A1 (en) 2014-03-28 2015-09-30 Spago Imaging AB Nanostructures and applications thereof
PL3465697T3 (en) * 2016-05-24 2020-11-16 Qsa Global Inc. Low density spherical iridium source
CN111012929B (en) * 2019-11-27 2022-05-17 原子高科股份有限公司 Suppository carrying radioactive particles and preparation method thereof
EP4241793A1 (en) 2022-03-08 2023-09-13 Spago Nanomedical AB Globular nanostructures
EP4241792A1 (en) 2022-03-08 2023-09-13 Spago Nanomedical AB Nanostructures and applications thereof

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6015541A (en) * 1997-11-03 2000-01-18 Micro Therapeutics, Inc. Radioactive embolizing compositions
US6248057B1 (en) * 1998-07-28 2001-06-19 Innerdyne, Inc. Absorbable brachytherapy and chemotherapy delivery devices and methods

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2676927B1 (en) * 1991-05-29 1995-06-23 Ibf MICROSPHERES FOR USE IN THERAPEUTIC VASCULAR OCCLUSIONS AND INJECTABLE SOLUTIONS CONTAINING THEM.
FR2784580B1 (en) * 1998-10-16 2004-06-25 Biosepra Inc POLYVINYL-ALCOHOL MICROSPHERES AND METHODS OF MAKING THE SAME
AUPR098300A0 (en) * 2000-10-25 2000-11-16 Sirtex Medical Limited Polymer based radionuclide containing microspheres

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6015541A (en) * 1997-11-03 2000-01-18 Micro Therapeutics, Inc. Radioactive embolizing compositions
US6248057B1 (en) * 1998-07-28 2001-06-19 Innerdyne, Inc. Absorbable brachytherapy and chemotherapy delivery devices and methods

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of EP1578455A4 *

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7964123B2 (en) 2004-06-01 2011-06-21 Boston Scientific Scimed, Inc. Embolization
US7727555B2 (en) 2005-03-02 2010-06-01 Boston Scientific Scimed, Inc. Particles
US8430105B2 (en) 2005-04-28 2013-04-30 Boston Scientific Scimed, Inc. Tissue-treatment methods
US9283035B2 (en) 2005-04-28 2016-03-15 Boston Scientific Scimed, Inc. Tissue-treatment methods
US9463426B2 (en) 2005-06-24 2016-10-11 Boston Scientific Scimed, Inc. Methods and systems for coating particles

Also Published As

Publication number Publication date
EP1578455A4 (en) 2008-12-31
WO2004040972A2 (en) 2004-05-21
EP1578455A2 (en) 2005-09-28
AU2003285905A1 (en) 2004-06-07
CA2507404A1 (en) 2004-05-21

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