WO2004026111B1 - Flexible and/or elastic brachytherapy seed or strand - Google Patents

Flexible and/or elastic brachytherapy seed or strand

Info

Publication number
WO2004026111B1
WO2004026111B1 PCT/US2003/029673 US0329673W WO2004026111B1 WO 2004026111 B1 WO2004026111 B1 WO 2004026111B1 US 0329673 W US0329673 W US 0329673W WO 2004026111 B1 WO2004026111 B1 WO 2004026111B1
Authority
WO
WIPO (PCT)
Prior art keywords
strand
seed
group
millimeters
brachytherapy
Prior art date
Application number
PCT/US2003/029673
Other languages
French (fr)
Other versions
WO2004026111A3 (en
WO2004026111A2 (en
Inventor
Edward J Kaplan
Original Assignee
Microspherix Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=32475685&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=WO2004026111(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Microspherix Llc filed Critical Microspherix Llc
Priority to EP03749783A priority Critical patent/EP1545705A4/en
Priority to JP2004538328A priority patent/JP2006500115A/en
Priority to AU2003267309A priority patent/AU2003267309A1/en
Publication of WO2004026111A2 publication Critical patent/WO2004026111A2/en
Publication of WO2004026111A3 publication Critical patent/WO2004026111A3/en
Publication of WO2004026111B1 publication Critical patent/WO2004026111B1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L31/16—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/06—Devices, other than using radiation, for detecting or locating foreign bodies ; determining position of probes within or on the body of the patient
    • A61B5/061—Determining position of a probe within the body employing means separate from the probe, e.g. sensing internal probe position employing impedance electrodes on the surface of the body
    • A61B5/064—Determining position of a probe within the body employing means separate from the probe, e.g. sensing internal probe position employing impedance electrodes on the surface of the body using markers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B90/00—Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges
    • A61B90/39—Markers, e.g. radio-opaque or breast lesions markers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0038—Radiosensitizing, i.e. administration of pharmaceutical agents that enhance the effect of radiotherapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6957—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a device or a kit, e.g. stents or microdevices
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/04—X-ray contrast preparations
    • A61K49/0409—Physical forms of mixtures of two different X-ray contrast-enhancing agents, containing at least one X-ray contrast-enhancing agent which is not a halogenated organic compound
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/12—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes, characterized by a special physical form, e.g. emulsions, dispersions, microcapsules
    • A61K51/1282—Devices used in vivo and carrying the radioactive therapeutic or diagnostic agent, therapeutic or in vivo diagnostic kits, stents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/02—Inorganic materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/04—Macromolecular materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/08—Materials for coatings
    • A61L31/10—Macromolecular materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L31/146—Porous materials, e.g. foams or sponges
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L31/148—Materials at least partially resorbable by the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L31/18—Materials at least partially X-ray or laser opaque
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
    • A61N5/1001—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy using radiation sources introduced into or applied onto the body; brachytherapy
    • A61N5/1007—Arrangements or means for the introduction of sources into the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
    • A61N5/1001—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy using radiation sources introduced into or applied onto the body; brachytherapy
    • A61N5/1027—Interstitial radiation therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B90/00—Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges
    • A61B90/39—Markers, e.g. radio-opaque or breast lesions markers
    • A61B2090/3966—Radiopaque markers visible in an X-ray image
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/44—Radioisotopes, radionuclides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/45—Mixtures of two or more drugs, e.g. synergistic mixtures
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
    • A61N5/1001—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy using radiation sources introduced into or applied onto the body; brachytherapy
    • A61N2005/1019—Sources therefor
    • A61N2005/1023—Means for creating a row of seeds, e.g. spacers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
    • A61N5/1001—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy using radiation sources introduced into or applied onto the body; brachytherapy
    • A61N2005/1019—Sources therefor
    • A61N2005/1024—Seeds

Abstract

A flexible or elastic brachytherapy strand (10) that includes an imaging marker (30) and/or a therapeutic, diagnostic or prophylactic agent (14) such as a drug (14) in a biocompatible carrier that can be delivered to a subject upon implantation needle. Strands (10) can be formed as chains or continuous arrays of seeds up to 50 centimeters or more, with or without spacer material (20) flaccid, rigid, or flexible.

Claims

AMENDED CLAIMS
[received by the International Bureau on 12 July 2004 (12.07.04); original claims 1-26 replaced by amended claims 1-30]
We claim:
1. A brachytherapy strand or seed for implantation into a subject comprising
(a) a non-radionuclide imaging marker, and
(b) a biocompatible carrier. wherein the strand or seed is elastic, and has a size and shape suitable for passing through the bore of a needle having an interior diameter of less than about 2.7 millimeters (10 gauge).
2. The strand or seed of claim 1 formed of a synthetic polymer.
3. The strand or seed of claim 1 formed of an inorganic material.
4. The strand or seed of claim 1 formed of a natural material selected from the group consisting of proteins, peptides, polysaccharides, lipi s, and combinations thereof.
5. The strand or seed of claim 1 formed of a shape memory material. β- The strand or seed of claim 1 further comprising a therapeutic, prophylactic or diagnostic agent.
7. The strand or seed of claim 1 further comprising conduits, cavities or pores along the length of the strand.
©. Thø stra d or seed of claim 7 further comprising a portal for external access using a needle or other introducer instrument for purposes of filling the conduits, cavities or pores with therapeutic or diagnostic agents after implantation.
9. The strand or seed of claim 1 further comprising a radioactive agent.
10. The strand or seed of claim 1 wherein the imaging marker is detectable by X-ray, fluorescence, infrared; ultrasound, magnetic detection, or MRΪ.
11. The strand or seed of claim 1 , wherein the size and shape is suitable for passing through the bore of a needle having an interior diameter of less than about 1.4 millimeters (15 gauge).
44
12. The strand or seed of claim 1 , wherein the strand or seed is shaped into a cylinder having a diameter of between about 0.5 to 3 millimeters and a length of 4 to 500 millimeters.
44A
13. The strand of claim 1 , wherein the strand comprises seeds strung on or formed as a strand of between about 0.5 and 3 mm diameter and a length of between one and 50 cm,
14. The strand or seed of claim 1 , wherein the carrier is biodegradable.
15. The strand or seed of claiml further comprising a material selected from the group consisting of ferromagnetic microspheres, oxygen, hemoglobin, synthetic hemoglobin-like substances and drugs for enhancing oxygen perfusion.
16. The strand of claim 1 , further comprising seeds.
17. The strand of claim 15, wherein the seeds are formed of a material selected from the group consisting of non-polymeric or inorganic materials and polymers.
18. The strand or seed of claim 9 further comprising a means of tracing the radioactive agent
19. The strand or seed of claim 1 further comprising a radiosensitizing agent.
20. The strand or seed of claim 1 wherein the imaging marker is a radiopaque marker comprising a substance selected from the group consisting of platinum, iridium,, rheniums, gold, tantal n3 bis u hs indium, tungsten, silver, and radiopaque polymers.
21. The strand or seed of claim 1 further comprising hairs coating the external surface of the brachytherapy strand for enhancement of adhesive potential.
22. The strand or seed of claim 1 further comprising polymeric anchoring structures.
23. The strand or seed of claim 22 wherein the anchoring structures are shape memory polymeric anchoring structures or electroactive polymeric anchoring structures.
24. The strand or seed of claim 3 wherein the inorganic material is selected from the group consisting of silicon, coral, fullerene, bioceramic, and hydroxyapatite.
45
25. The strand or seed of claim 1 wherein the strand or seed is formed of a composite of an inorganic material and a polymer.
26. The strand or seed of claim 6, comprising one or more areas comprising a therapeutic, prophylactic or diagnostic agent and one ore more areas comprising spacers.
27. The strand of claim 1 , wherein the strand forms a mesh or lattice.
28. A method of making a brachytherapy strand or seed for implantation into a subject comprising mixing a biocompatible elastic carrier with a non-radioactive imaging agent to form a brachytherapy strand or seed.
29- A method for adrninisteriπg a therapeutically active component to a target tissue in a subject, the method comprising implanting a brachytherapy strand or seed comprising
(a) a non-radionuclide imaging marker, and
(b) a biocompatible carrier, wherein the strand or seed is elastic, and has a size and shape suitable for passing through the bore of a needle having an interior diameter of less than about 2.7 millimeters (10 gauge). 30. The method of claim 30, wherein the target tissue is a diseased tissue selected from the group consisting of prostate, breast and tongue.
46
PCT/US2003/029673 2000-11-16 2003-09-19 Flexible and/or elastic brachytherapy seed or strand WO2004026111A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
EP03749783A EP1545705A4 (en) 2000-11-16 2003-09-19 Flexible and/or elastic brachytherapy seed or strand
JP2004538328A JP2006500115A (en) 2000-11-16 2003-09-19 Flexible and / or elastic seeds or strands for brachytherapy
AU2003267309A AU2003267309A1 (en) 2000-11-16 2003-09-19 Flexible and/or elastic brachytherapy seed or strand

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US24912800P 2000-11-16 2000-11-16
US41205002P 2002-09-19 2002-09-19
US60/412,050 2002-09-19

Publications (3)

Publication Number Publication Date
WO2004026111A2 WO2004026111A2 (en) 2004-04-01
WO2004026111A3 WO2004026111A3 (en) 2004-07-01
WO2004026111B1 true WO2004026111B1 (en) 2004-08-26

Family

ID=32475685

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2003/029673 WO2004026111A2 (en) 2000-11-16 2003-09-19 Flexible and/or elastic brachytherapy seed or strand

Country Status (5)

Country Link
US (7) US7776310B2 (en)
EP (1) EP1545705A4 (en)
JP (1) JP2006500115A (en)
AU (1) AU2003267309A1 (en)
WO (1) WO2004026111A2 (en)

Families Citing this family (124)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8114006B2 (en) * 1998-10-06 2012-02-14 University Of South Florida Radio guided seed localization of imaged lesions
WO2004026111A2 (en) 2000-11-16 2004-04-01 Microspherix Llc Flexible and/or elastic brachytherapy seed or strand
GB0104383D0 (en) * 2001-02-22 2001-04-11 Psimedica Ltd Cancer Treatment
US7060020B2 (en) 2001-11-02 2006-06-13 Ideamatrix, Inc. Delivery system and method for interstitial radiation therapy
US7074291B2 (en) * 2001-11-02 2006-07-11 Worldwide Medical Technologies, L.L.C. Delivery system and method for interstitial radiation therapy using strands constructed with extruded strand housings
US6969395B2 (en) * 2002-08-07 2005-11-29 Boston Scientific Scimed, Inc. Electroactive polymer actuated medical devices
US8027712B2 (en) * 2002-10-11 2011-09-27 Ion Beam Applications S.A. Elongated markers for soft tissue volume identification
NZ539779A (en) * 2002-11-05 2009-01-31 Spineology Inc A semi-biological intervertebral disc replacement system created by inserting tissue promoting material into a cavity in the disc
US7322928B2 (en) * 2003-03-17 2008-01-29 Medi-Physics, Inc. Products and methods for brachytherapy
US6997862B2 (en) 2003-05-13 2006-02-14 Ideamatrix, Inc. Delivery system and method for interstitial radiation therapy using seed strands with custom end spacing
DE10359252A1 (en) * 2003-12-17 2005-07-28 Siemens Ag Navigated heat treatment of tumors with enzyme-coated iron particles
GB0329654D0 (en) 2003-12-23 2004-01-28 Smith & Nephew Tunable segmented polyacetal
US7582050B2 (en) * 2004-03-31 2009-09-01 The Regents Of The University Of California Apparatus for hyperthermia and brachytherapy delivery
EP1778119A1 (en) * 2004-08-09 2007-05-02 Koninklijke Philips Electronics N.V. Processing of images of interventional instruments with markers
WO2007017847A1 (en) 2005-08-11 2007-02-15 Navotek Medical Ltd. Medical treatment system and method using radioactivity based position sensor
EP1681077A1 (en) * 2005-01-12 2006-07-19 Acrostak Corp. A positioning device and a procedure for treating the walls of a resection cavity
AU2006209421A1 (en) * 2005-01-31 2006-08-03 Bioserentach Co., Ltd. Transdermal absorption preparation, sheet holding transdermal absorption preparation and transdermal absorption preparation holder
US9877806B2 (en) 2005-05-17 2018-01-30 Yeda Research And Development Co. Ltd. Low friction coatings for use in dental and medical devices
US8187159B2 (en) * 2005-07-22 2012-05-29 Biocompatibles, UK Therapeutic member including a rail used in brachytherapy and other radiation therapy
US7736293B2 (en) * 2005-07-22 2010-06-15 Biocompatibles Uk Limited Implants for use in brachytherapy and other radiation therapy that resist migration and rotation
BRPI0616514A2 (en) 2005-08-11 2011-06-21 Navotek Medical Ltd medical treatment system and method using position sensor based radioactivity
US20070191707A1 (en) * 2005-09-15 2007-08-16 Denittis Albert S Device for locating the cervix and uterus
AU2006304089A1 (en) * 2005-10-12 2007-04-26 C.R. Bard, Inc. Packaging system for brachytherapy devices
WO2007053823A2 (en) * 2005-10-31 2007-05-10 Biolucent, Inc. Brachytherapy apparatus and methods of using same
US8137256B2 (en) * 2005-12-16 2012-03-20 Portola Medical, Inc. Brachytherapy apparatus
US20070270627A1 (en) * 2005-12-16 2007-11-22 North American Scientific Brachytherapy apparatus for asymmetrical body cavities
ES2321123T3 (en) * 2006-01-10 2009-06-02 Acrostak Corp. Bvi IMPLANT TO TREAT THE INTERNAL WALLS OF A RESECTION CAVITY.
US8170647B2 (en) * 2006-01-20 2012-05-01 Best Medical International, Inc Fiduciary markers and method of use thereof
US20070265487A1 (en) * 2006-05-09 2007-11-15 Worldwide Medical Technologies Llc Applicators for use in positioning implants for use in brachytherapy and other radiation therapy
US7988611B2 (en) * 2006-05-09 2011-08-02 Biocompatibles Uk Limited After-loader for positioning implants for needle delivery in brachytherapy and other radiation therapy
EP2032194B1 (en) 2006-06-05 2016-08-24 Ecoluminaire Limited A fluid conveying conduit
US8771162B2 (en) * 2010-04-23 2014-07-08 Eckert & Ziegler Bebig S. A. Spacers for use in brachytherapy, radiotherapy, and other medical therapy
US20090216063A1 (en) * 2008-01-29 2009-08-27 Biocompatibles Uk Limited Bio-absorbable brachytherapy strands
US20080071132A1 (en) * 2006-07-21 2008-03-20 Lamoureux Gary A Brachytherapy apparatus and method for treating tissue forming an internal body cavity
WO2008027402A2 (en) * 2006-08-29 2008-03-06 Civatech Oncology Brachytherapy devices and related methods and computer program products
US7878964B1 (en) 2006-09-07 2011-02-01 Biocompatibles Uk Limited Echogenic spacers and strands
US7874976B1 (en) 2006-09-07 2011-01-25 Biocompatibles Uk Limited Echogenic strands and spacers therein
WO2008058089A2 (en) * 2006-11-03 2008-05-15 North American Scientific, Inc. Brachytherapy device having seed tubes with individually-settable tissue spacings
CA2679365C (en) 2006-11-30 2016-05-03 Smith & Nephew, Inc. Fiber reinforced composite material
US9456983B1 (en) * 2006-12-08 2016-10-04 Advanced Cardiovascular Systems, Inc. Therapeutic composition with enhanced vessel targeting
JP5416090B2 (en) 2007-04-18 2014-02-12 スミス アンド ネフュー ピーエルシー Expansion molding of shape memory polymer
DE602008006181D1 (en) 2007-04-19 2011-05-26 Smith & Nephew Inc GRAFT FIXATION
US9000066B2 (en) 2007-04-19 2015-04-07 Smith & Nephew, Inc. Multi-modal shape memory polymers
US20080269540A1 (en) * 2007-04-27 2008-10-30 Worldwide Medical Technologies Llc Seed cartridge adaptor and methods for use therewith
US8529872B2 (en) * 2007-07-11 2013-09-10 Board Of Regents, The University Of Texas System Seeds and markers for use in imaging
US20090030260A1 (en) * 2007-07-25 2009-01-29 Mick Radio-Nuclear Instruments, Inc. Seed anchor
US9592100B2 (en) * 2007-12-31 2017-03-14 St. Jude Medical, Atrial Fibrillation Division, Inc. Method and apparatus for encoding catheters with markers for identifying with imaging systems
CA2721835C (en) * 2008-04-24 2017-06-20 The Australian National University Methods for radiolabelling synthetic polymers
US8821364B2 (en) * 2008-09-02 2014-09-02 Battelle Memorial Institute Brachytherapy seed with fast dissolving matrix for optimal delivery of radionuclides to cancer tissue
US9174028B2 (en) * 2009-03-02 2015-11-03 Positive Energy, Llc Rough bio-absorbable strands for seed placement
US8663210B2 (en) 2009-05-13 2014-03-04 Novian Health, Inc. Methods and apparatus for performing interstitial laser therapy and interstitial brachytherapy
US9014787B2 (en) 2009-06-01 2015-04-21 Focal Therapeutics, Inc. Bioabsorbable target for diagnostic or therapeutic procedure
US10634741B2 (en) 2009-12-04 2020-04-28 Endomagnetics Ltd. Magnetic probe apparatus
US9427186B2 (en) 2009-12-04 2016-08-30 Endomagnetics Ltd. Magnetic probe apparatus
CA2791990A1 (en) * 2010-03-01 2011-09-09 Intraop Medical Corporation Radiotherapy combined with hypoxic cell sensitizers
EP2549933A4 (en) * 2010-03-25 2015-10-14 Covidien Lp Chemical knots for sutures
JP5099461B2 (en) * 2010-05-11 2012-12-19 株式会社エーイーティー Focal tissue real-time position identification apparatus and X-ray therapy apparatus using the same
JP5873238B2 (en) * 2010-09-22 2016-03-01 テルモ株式会社 Bioadhesive sheet and sheet bonding device
WO2012045040A1 (en) * 2010-10-01 2012-04-05 Varian Medical Systems, Inc. Laser accelerator driven particle brachytherapy devices, systems, and methods
KR101200396B1 (en) 2010-10-07 2012-11-12 주식회사 엠에이에스 Pharmacothread for pharmacopuncture of Oriental medicine
CN103442737B (en) 2011-01-20 2017-03-29 得克萨斯系统大学董事会 MRI labellings, delivering and extraction system and its manufacture method and purposes
US20120209078A1 (en) * 2011-02-15 2012-08-16 Tyco Healthcare Group Lp Compliance access device including proximal adhesive patch
US10350431B2 (en) 2011-04-28 2019-07-16 Gt Medical Technologies, Inc. Customizable radioactive carriers and loading system
WO2012149581A1 (en) 2011-04-28 2012-11-01 Peter Nakaji Apparatus for loading dosimetrically customizable brachytherapy carriers
WO2012154988A2 (en) * 2011-05-11 2012-11-15 The Regents Of The University Of California Fiduciary markers and methods of placement
WO2013029024A1 (en) * 2011-08-25 2013-02-28 Civatech Oncology Brachytherapy devices and related methods having microencapsulated brachytherapy materials
US9943706B2 (en) 2012-01-12 2018-04-17 Surgical Radiation Products, Llc Targeting implant for external beam radiation
US9320517B2 (en) 2012-01-12 2016-04-26 Surgical Radiation Products, Llc Targeting implant for external beam radiation
WO2013112350A1 (en) * 2012-01-24 2013-08-01 Lifecell Corporation Elongated tissue matrices
US9798856B2 (en) * 2012-03-21 2017-10-24 Koninklijke Philips N.V. Clinical workstation integrating medical imaging and biopsy data and methods using same
US20130289389A1 (en) 2012-04-26 2013-10-31 Focal Therapeutics Surgical implant for marking soft tissue
KR101396642B1 (en) 2012-09-03 2014-05-16 이준길 A stitching fiber for plastic surgery
US10356889B1 (en) * 2012-11-09 2019-07-16 Euclid Techlabs LLC Passive method for controlling and correcting energy correlations in charged particle beams
BR112015022129B1 (en) 2013-03-11 2022-04-19 Endomagnetics Ltd Hyposmotic solutions for lymph node detection
US9234877B2 (en) 2013-03-13 2016-01-12 Endomagnetics Ltd. Magnetic detector
US9239314B2 (en) 2013-03-13 2016-01-19 Endomagnetics Ltd. Magnetic detector
US9492683B2 (en) 2013-03-15 2016-11-15 Gammatile Llc Dosimetrically customizable brachytherapy carriers and methods thereof in the treatment of tumors
CN105407955B (en) 2013-03-15 2018-11-13 波士顿科学公司 The device and method for conveying drug
KR101367780B1 (en) 2013-05-02 2014-02-28 주식회사 메타바이오메드 Manufacturing method of a suture for oriental medicine
ES2534810B1 (en) * 2013-05-31 2015-11-10 Josep Soler Cegarra Dental implant
WO2014205076A1 (en) 2013-06-20 2014-12-24 Source Production & Equipment Co., Inc. Radioactive therapeutic device with fixation
US10029834B2 (en) * 2013-10-15 2018-07-24 Thomas & Betts International Llc Cable tie employing composite of nylon and carbon nanotubes
US11446413B2 (en) 2014-01-06 2022-09-20 Yeda Research And Development Co. Ltd. Attenuation of encrustation of medical devices using coatings of inorganic fullerene-like nanoparticles
WO2015142316A1 (en) * 2014-03-17 2015-09-24 Brachman David Dosimetrically customizable brachytherapy carriers and methods thereof in the treatment of tumors
EP3171820B1 (en) 2014-07-25 2022-11-16 Hologic, Inc. Implantable devices and techniques for oncoplastic surgery
US11129691B2 (en) * 2014-12-16 2021-09-28 Koninklijke Philips N.V. Pulsed-light emitting marker device
HUE060224T2 (en) 2014-12-24 2023-02-28 Univ North Carolina Chapel Hill Combined local delivery of therapeutic agents using interventional devices and radiation
US9821174B1 (en) 2015-02-06 2017-11-21 Gammatile Llc Radioactive implant planning system and placement guide system
KR101682954B1 (en) * 2015-04-09 2016-12-06 21세기메디칼 주식회사 Solid filler for plasty surgery
US9403033B1 (en) 2015-04-24 2016-08-02 Gammatile Llc Apparatus and method for loading radioactive seeds into carriers
US9526463B2 (en) 2015-05-06 2016-12-27 Gammatile Llc Radiation shielding
CN113558782A (en) 2015-06-04 2021-10-29 安都磁学有限公司 Marker materials and forms for Magnetic Marker Localization (MML)
US10595956B2 (en) * 2015-11-25 2020-03-24 Camtomsam AB Marker loading assembly
US10159850B2 (en) 2016-01-06 2018-12-25 Covidien Lp Brachytherapy clip and applicator
BR112018070259A2 (en) 2016-03-31 2019-01-29 Univ Drexel tumor bed implant for multimodal treatment of at-risk tissue surrounding a resection cavity
US10230110B2 (en) * 2016-09-01 2019-03-12 Composite Materials Technology, Inc. Nano-scale/nanostructured Si coating on valve metal substrate for LIB anodes
US10888710B1 (en) 2016-11-29 2021-01-12 Gt Medical Technologies, Inc. Transparent loading apparatus
CN108272538B (en) * 2016-12-30 2020-06-12 先健科技(深圳)有限公司 Elastic implant for lung volume reduction and lung volume reduction instrument
CN106823120B (en) * 2017-01-24 2024-01-16 原子高科股份有限公司 Preparation method of degradable radioactive particle chain with shape memory function
CN106621076A (en) * 2017-02-06 2017-05-10 浙江荣诚医疗科技有限公司 Cobalt-zirconium gold marker implant and gold marker implantation apparatus
CN106621077A (en) * 2017-02-06 2017-05-10 浙江荣诚医疗科技有限公司 Hollowed-out gold mark and gold mark location device
CN108498939B (en) * 2017-02-28 2020-08-25 武汉大学 Radioactive particles capable of self-fixing position
US20180289467A1 (en) * 2017-04-05 2018-10-11 Ernesto Andrade Dispensing device, kit, and method for tissue augmentation
CA3059534A1 (en) 2017-05-11 2018-11-15 Alpha Tau Medical Ltd. Polymer coatings for brachytherapy devices
DE102017211835A1 (en) * 2017-07-11 2019-01-17 Bip Biomedizinische Instrumente Und Produkte Gmbh Medical, implantable marker and device for implanting the marker
CN107233580B (en) * 2017-07-27 2021-03-02 上海安翰医疗技术有限公司 Marking capsule for target area dynamic detection and preparation method thereof
GB201714392D0 (en) 2017-09-07 2017-10-25 Marsteller Laurence Methods and devices for treating glaucoma
US11666780B2 (en) * 2017-09-07 2023-06-06 Radiance Therapeutics, Inc. Methods, systems, and compositions for maintaining functioning drainage blebs associated with minimally invasive micro sclerostomy
WO2021142298A1 (en) * 2020-01-08 2021-07-15 Radiance Therapeutics, Inc. Methods, systems, and compositions for maintaining functioning drainage blebs
EP3703804B1 (en) 2017-11-02 2022-02-16 IsoRay Medical, Inc. Device for loading brachytherapy seeds into implantation sleeves
CN108307383B (en) 2018-01-18 2020-10-09 Oppo广东移动通信有限公司 Data reporting method and related product
US11331161B2 (en) * 2018-03-23 2022-05-17 Covidien Lp Surgical assemblies facilitating tissue marking and methods of use thereof
WO2020056467A1 (en) * 2018-09-23 2020-03-26 University Of Wollongong An implantable device and a method for implanting said device in a subject
CN109173091A (en) * 2018-09-25 2019-01-11 天津赛德医药研究院有限公司 It is a kind of easily from the Inner irradiation device taken out in vivo
US10981018B2 (en) 2019-02-14 2021-04-20 Gt Medical Technologies, Inc. Radioactive seed loading apparatus
EP3753524B1 (en) * 2019-06-20 2024-03-20 AURA Health Technologies GmbH Ultrasound marker, ultrasound marker system and method of operating an ultrasound marker system
US11406489B2 (en) 2019-10-07 2022-08-09 Cornell University Implant with fiducial markers
CA3171096A1 (en) * 2020-03-12 2021-09-16 Manny R. Subramanian Radiotherapy applicator system
CA3189134A1 (en) * 2020-08-10 2022-02-17 Charles Martin Iii Biodegradable adhesive with radioisotopes
CN112472995B (en) * 2020-12-07 2022-08-12 杨云伟 Silicone stent with radioactive particles for department of respiration
US11857803B2 (en) 2020-12-16 2024-01-02 Alpha Tau Medical Ltd. Diffusing alpha-emitter radiation therapy with enhanced beta treatment
WO2023012223A1 (en) * 2021-08-04 2023-02-09 Surgmark Gmbh Tissue marker
US20230211176A1 (en) * 2021-12-30 2023-07-06 Gt Medical Technologies, Inc. Radiation shielding apparatus for implantable radioactive seeds
US20230310666A1 (en) * 2022-03-29 2023-10-05 Arnold M. Herskovic Radioactive condujit and method for in vivo treatment of tumors

Family Cites Families (361)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1578945A (en) * 1923-01-08 1926-03-30 Sanford M Withers Radium needle structure
US2067589A (en) * 1935-10-08 1937-01-12 Louis C Antrim Fertilizing stick
US2153889A (en) * 1937-07-20 1939-04-11 J A Deknatel & Son Inc Suture
US2269963A (en) * 1940-06-01 1942-01-13 Wappler Frederick Charles Implanting device
US2575138A (en) 1948-10-29 1951-11-13 Charles E Slaughter Method and apparatus for packaging and package
US2703316A (en) * 1951-06-05 1955-03-01 Du Pont Polymers of high melting lactide
US2668162A (en) * 1952-03-20 1954-02-02 Du Pont Preparation of high molecular weight polyhydroxyacetic ester
US2758987A (en) 1952-06-05 1956-08-14 Du Pont Optically active homopolymers containing but one antipodal species of an alpha-monohydroxy monocarboxylic acid
US3187752A (en) 1962-04-27 1965-06-08 American Cyanamid Co Non-absorbable silicone coated sutures and method of making
US3297033A (en) * 1963-10-31 1967-01-10 American Cyanamid Co Surgical sutures
US3351049A (en) 1965-04-12 1967-11-07 Hazleton Nuclear Science Corp Therapeutic metal seed containing within a radioactive isotope disposed on a carrier and method of manufacture
US3565869A (en) * 1968-12-23 1971-02-23 American Cyanamid Co Extrudable and stretchable polyglycolic acid and process for preparing same
US3993073A (en) 1969-04-01 1976-11-23 Alza Corporation Novel drug delivery device
CA927032A (en) * 1969-06-30 1973-05-22 H. Beacham Harry Flame-retardant resin compositions
BE758156R (en) * 1970-05-13 1971-04-28 Ethicon Inc ABSORBABLE SUTURE ELEMENT AND ITS
US3625214A (en) 1970-05-18 1971-12-07 Alza Corp Drug-delivery device
US3839297A (en) 1971-11-22 1974-10-01 Ethicon Inc Use of stannous octoate catalyst in the manufacture of l(-)lactide-glycolide copolymer sutures
US3752630A (en) 1972-01-05 1973-08-14 Takagi H Apparatus for continuous production of thermoplastic synthetic resin tube with heat-shrinking property
US3867519A (en) 1972-04-27 1975-02-18 Alza Corp Bioerodible drug delivery device
US4351337A (en) 1973-05-17 1982-09-28 Arthur D. Little, Inc. Biodegradable, implantable drug delivery device, and process for preparing and using the same
US3811426A (en) * 1973-05-21 1974-05-21 Atomic Energy Commission Method and apparatus for the in-vessel radiation treatment of blood
DE2445971A1 (en) 1974-09-24 1976-04-08 Schering Ag MEDICINAL INGREDIENTS CARRIERS II
US4093709A (en) 1975-01-28 1978-06-06 Alza Corporation Drug delivery devices manufactured from poly(orthoesters) and poly(orthocarbonates)
US4052988A (en) 1976-01-12 1977-10-11 Ethicon, Inc. Synthetic absorbable surgical devices of poly-dioxanone
US4391797A (en) 1977-01-05 1983-07-05 The Children's Hospital Medical Center Systems for the controlled release of macromolecules
US4141087A (en) * 1977-01-19 1979-02-27 Ethicon, Inc. Isomorphic copolyoxalates and sutures thereof
US4086914A (en) * 1977-02-11 1978-05-02 Edwin Bailey Moore Implant injector
US4167179A (en) 1977-10-17 1979-09-11 Mark Kirsch Planar radioactive seed implanter
US4247406A (en) * 1979-04-23 1981-01-27 Widder Kenneth J Intravascularly-administrable, magnetically-localizable biodegradable carrier
US4343931A (en) 1979-12-17 1982-08-10 Minnesota Mining And Manufacturing Company Synthetic absorbable surgical devices of poly(esteramides)
US4323055A (en) 1980-04-08 1982-04-06 Minnesota Mining And Manufacturing Company Radioactive iodine seed
US4343715A (en) 1980-10-10 1982-08-10 Duke University Immobilized hemoglobin, and processes for extracting oxygen from fluids using the same
US4402308A (en) 1980-11-03 1983-09-06 Scott Walter P Medical implantation device
IE52535B1 (en) 1981-02-16 1987-12-09 Ici Plc Continuous release pharmaceutical compositions
US4509506A (en) 1981-05-11 1985-04-09 Minnesota Mining & Manufacturing Co. Shielding device for radioactive seed
JPS57206622A (en) 1981-06-10 1982-12-18 Ajinomoto Co Inc Blood substitute
US4689424A (en) 1981-08-06 1987-08-25 Ethicon, Inc. Radiation sterilizable absorbable polymeric materials and methods for manufacturing the same
DE8123912U1 (en) 1981-08-17 1982-01-14 B. Braun Melsungen Ag, 3508 Melsungen PLASTIC PROBE
US4569836A (en) * 1981-08-27 1986-02-11 Gordon Robert T Cancer treatment by intracellular hyperthermia
US4416659A (en) 1981-11-09 1983-11-22 Eli Lilly And Company Sustained release capsule for ruminants
US4379138A (en) 1981-12-28 1983-04-05 Research Triangle Institute Biodegradable polymers of lactones
US4441496A (en) * 1982-02-08 1984-04-10 Ethicon, Inc. Copolymers of p-dioxanone and 2,5-morpholinediones and surgical devices formed therefrom having accelerated absorption characteristics
US4427005A (en) 1982-03-04 1984-01-24 Tener William S Apparatus and method for treating breast tumors
US4452973A (en) 1982-11-12 1984-06-05 American Cyanamid Company Poly(glycolic acid)/poly(oxyethylene) triblock copolymers and method of manufacturing the same
US4510295A (en) * 1983-01-20 1985-04-09 Ethicon, Inc. Absorbable polymers of substituted benzoic acid
US4473670A (en) 1983-05-25 1984-09-25 Ethicon, Inc. Salt-filled absorbable polymers
US4612923A (en) 1983-12-01 1986-09-23 Ethicon, Inc. Glass-filled, absorbable surgical devices
EP0165993A1 (en) * 1983-12-27 1986-01-02 The Board Of Trustees Of The Leland Stanford Junior University Catheter for treatment of tumors and method for using same
LU85320A1 (en) 1984-04-17 1985-11-27 Oreal COSMETIC COMPOSITION CONTAINING ALOESIN AS A PROTECTIVE AGENT AGAINST SUNLIGHT AND ITS USE FOR PROTECTING SKIN AND HAIR
US4621638A (en) 1984-07-30 1986-11-11 Pfizer Hospital Products Group, Inc. Hard elastic sutures
US4646741A (en) * 1984-11-09 1987-03-03 Ethicon, Inc. Surgical fastener made from polymeric blends
US4754745A (en) 1984-11-21 1988-07-05 Horowitz Bruce S Conformable sheet material for use in brachytherapy
US4697575A (en) 1984-11-21 1987-10-06 Henry Ford Hospital Delivery system for interstitial radiation therapy including substantially non-deflecting elongated member
GB8430703D0 (en) 1984-12-05 1985-01-16 Lrc Products Drug release devices
US4702228A (en) 1985-01-24 1987-10-27 Theragenics Corporation X-ray-emitting interstitial implants
US4616656A (en) 1985-03-19 1986-10-14 Nicholson James E Self-actuating breast lesion probe and method of using
US4741337A (en) * 1985-07-17 1988-05-03 Ethicon, Inc. Surgical fastener made from glycolide-rich polymer blends
DE3682723D1 (en) 1985-08-15 1992-01-16 Asahi Denka Kogyo Kk RADIATION SENSITIZER.
US5322499A (en) 1985-09-20 1994-06-21 Liprie Sam F Continuous sheated low dose radioactive core adapted for cutting into short sealed segments
US4700692A (en) 1985-12-23 1987-10-20 Baumgartner George C Surgical implantation method and apparatus
US4706652A (en) 1985-12-30 1987-11-17 Henry Ford Hospital Temporary radiation therapy
US4763642A (en) 1986-04-07 1988-08-16 Horowitz Bruce S Intracavitational brachytherapy
US4866132A (en) 1986-04-17 1989-09-12 The Research Foundation Of State University Of New York Novel radiopaque barium polymer complexes, compositions of matter and articles prepared therefrom
US4885254A (en) 1986-06-25 1989-12-05 University Of Connecticut Fluorescene technique to monitor cure in polymers
US4789724A (en) 1986-10-17 1988-12-06 Massachusetts Institute Of Technology Preparation of anhydride copolymers
US4799495A (en) 1987-03-20 1989-01-24 National Standard Company Localization needle assembly
ES2054784T3 (en) 1987-08-08 1994-08-16 Akzo Nv A METHOD FOR THE MANUFACTURE OF AN IMPLANT.
EP0304107B1 (en) 1987-08-18 1992-01-15 Akzo N.V. Implant injection device
US4772287A (en) 1987-08-20 1988-09-20 Cedar Surgical, Inc. Prosthetic disc and method of implanting
US4847505A (en) 1987-11-02 1989-07-11 Best Industries, Inc. Storage and transport containers for radioactive medical materials
US4916209A (en) * 1987-12-23 1990-04-10 Pfizer Inc. Bioabsorbable polydepsipeptide, preparation and use thereof
US4926860A (en) * 1988-02-05 1990-05-22 Flexmedics Corporation ARthroscopic instrumentation and method
US4936823A (en) 1988-05-04 1990-06-26 Triangle Research And Development Corp. Transendoscopic implant capsule
IL86549A (en) 1988-05-30 1991-04-15 Hydro Plan Eng Ltd Process and installation for producing a drip irrigation conduit
US4891165A (en) 1988-07-28 1990-01-02 Best Industries, Inc. Device and method for encapsulating radioactive materials
US4946435A (en) 1988-10-24 1990-08-07 Best Industries, Inc. Flexible sealed radioactive film for radiotherapy, and method of making same
US5205289A (en) 1988-12-23 1993-04-27 Medical Instrumentation And Diagnostics Corporation Three-dimensional computer graphics simulation and computerized numerical optimization for dose delivery and treatment planning
US5019400A (en) * 1989-05-01 1991-05-28 Enzytech, Inc. Very low temperature casting of controlled release microspheres
US5030195A (en) 1989-06-05 1991-07-09 Nardi George L Radioactive seed patch for prophylactic therapy
US5011473A (en) 1989-06-06 1991-04-30 Mitek Surgical Products Inc. Device for securing and positioning a wire to a needle
US5707644A (en) * 1989-11-04 1998-01-13 Danbiosyst Uk Limited Small particle compositions for intranasal drug delivery
US5271961A (en) 1989-11-06 1993-12-21 Alkermes Controlled Therapeutics, Inc. Method for producing protein microspheres
US5284144A (en) * 1989-11-22 1994-02-08 The United States Of America As Represented By The Secretary Of The Dept. Of Health & Human Services Apparatus for hyperthermia treatment of cancer
US5059166A (en) 1989-12-11 1991-10-22 Medical Innovative Technologies R & D Limited Partnership Intra-arterial stent with the capability to inhibit intimal hyperplasia
US5000912A (en) * 1989-12-15 1991-03-19 Ethicon, Inc. Nickel titanium martensitic steel for surgical needles
US5179189A (en) 1990-01-19 1993-01-12 Nova Pharmaceutical Corporation Fatty acid terminated polyanhydrides
IN172208B (en) 1990-04-02 1993-05-01 Sint Sa
GB2245559A (en) * 1990-06-25 1992-01-08 Farmos Oy Bioceramic system for delivery of a bioactive compound.
AT397468B (en) 1990-07-11 1994-04-25 Oesterr Forsch Seibersdorf SPOTLIGHT HOLDER AND METHOD AND DEVICE FOR PRODUCING THE SAME
US5179789A (en) * 1990-08-01 1993-01-19 The Coe Manufacturing Company (Canada), Inc. Kiln with automatic control of heat distribution
US6099457A (en) 1990-08-13 2000-08-08 Endotech, Inc. Endocurietherapy
US5342283A (en) 1990-08-13 1994-08-30 Good Roger R Endocurietherapy
US5620700A (en) 1990-10-30 1997-04-15 Alza Corporation Injectable drug delivery system and method
US5429582A (en) 1991-06-14 1995-07-04 Williams; Jeffery A. Tumor treatment
BE1005080A3 (en) 1991-07-19 1993-04-13 Solvay Soc Anomyme Flexible film, and resilient biodegradable polymer based lactic acid may be suitable especially for making medical dressing.
US5219358A (en) 1991-08-29 1993-06-15 Ethicon, Inc. Shape memory effect surgical needles
US5242373A (en) 1991-09-17 1993-09-07 Scott Walter P Medical seed implantation instrument
US5324503A (en) * 1992-02-06 1994-06-28 Mallinckrodt Medical, Inc. Iodo-phenylated chelates for x-ray contrast
EP0627941A1 (en) 1992-02-28 1994-12-14 ORDER, Stanley E. Use of aggregated proteins to prolong retention time of a therapeutic agent adjacent a targeted site such as a tumor
US5424288A (en) 1992-02-28 1995-06-13 Order; Stanley E. Method of treating solid tumor cancers utilizing macro aggregated proteins and colloidal radioactive phosphorous
US6197346B1 (en) 1992-04-24 2001-03-06 Brown Universtiy Research Foundation Bioadhesive microspheres and their use as drug delivery and imaging systems
US5629008A (en) 1992-06-02 1997-05-13 C.R. Bard, Inc. Method and device for long-term delivery of drugs
US5264540A (en) 1992-07-20 1993-11-23 Ethicon, Inc. Aromatic polyanhydrides
US5279555A (en) 1992-08-24 1994-01-18 Merck & Co., Inc. Device for injecting implants
US5391139A (en) * 1992-09-03 1995-02-21 William Beaumont Hospital Real time radiation treatment planning system
US5670173A (en) 1992-09-14 1997-09-23 Mcgill University Biodegradable polymer membrane containing hemoglobin for blood substitute
US5397816A (en) * 1992-11-17 1995-03-14 Ethicon, Inc. Reinforced absorbable polymers
US5429634A (en) 1993-09-09 1995-07-04 Pdt Systems Biogenic implant for drug delivery and method
KR940018448A (en) 1993-01-21 1994-08-18 피터 씨. 샬크비즈크; 권터 페트 Thermochromic infrared dyes
US5486360A (en) 1993-04-22 1996-01-23 St. Joseph Health Centre Method of treating tumour cells using catalase
US5405309A (en) 1993-04-28 1995-04-11 Theragenics Corporation X-ray emitting interstitial implants
DE4320754A1 (en) 1993-06-23 1995-01-05 Hoechst Ag Device for applying implants
US5886026A (en) 1993-07-19 1999-03-23 Angiotech Pharmaceuticals Inc. Anti-angiogenic compositions and methods of use
WO1995003036A1 (en) 1993-07-19 1995-02-02 Angiogenesis Technologies, Inc. Anti-angiogenic compositions and methods of use
EP0711179B2 (en) 1993-07-30 2010-09-01 IMCOR Pharmaceutical Co. Stabilized microbubble compositions for ultrasound
WO1995010267A1 (en) 1993-10-08 1995-04-20 The United States Of America, Represented By The Secretary, Department Of Health And Human Services Use of nitric oxide-releasing compounds as hypoxic cell radiation sensitizers
GB9323498D0 (en) 1993-11-15 1994-01-05 Isis Innovation Making particles of uniform size
US5429583A (en) 1993-12-09 1995-07-04 Pegasus Medical Technologies, Inc. Cobalt palladium seeds for thermal treatment of tumors
ATE391769T1 (en) * 1994-01-03 2008-04-15 Promega Corp MUTATED LUCIFERASES
US5460592A (en) 1994-01-24 1995-10-24 Amersham Holdings, Inc. Apparatus and method for making carrier assembly for radioactive seed carrier
GB9401577D0 (en) 1994-01-27 1994-03-23 Sheffield Orthodontic Lab Limi Polymer material suitable for the production of medical artifacts
US5626861A (en) 1994-04-01 1997-05-06 Massachusetts Institute Of Technology Polymeric-hydroxyapatite bone composite
US5567410A (en) * 1994-06-24 1996-10-22 The General Hospital Corporation Composotions and methods for radiographic imaging
AU2768295A (en) 1994-07-11 1996-02-09 Hoechst Marion Roussel, Inc. Method of treating a neoplastic disease state by conjunctive therapy with 2'-fluoromethylidene derivatives and radiation or chemotherapy
US6162236A (en) 1994-07-11 2000-12-19 Terumo Kabushiki Kaisha Trocar needle and expandable trocar tube
US5626862A (en) 1994-08-02 1997-05-06 Massachusetts Institute Of Technology Controlled local delivery of chemotherapeutic agents for treating solid tumors
DK0777503T3 (en) 1994-08-19 2000-03-20 Biomat Bv Radiopaque polymers and processes for their preparation
DE4440346A1 (en) 1994-11-13 1996-05-15 Daum Gmbh Puncture instrument
US5626829A (en) 1994-11-16 1997-05-06 Pgk, Enterprises, Inc. Method and apparatus for interstitial radiation of the prostate gland
US5670356A (en) 1994-12-12 1997-09-23 Promega Corporation Modified luciferase
AU5025096A (en) 1995-02-27 1996-09-18 Instent Inc. Hollow stent
US6246898B1 (en) 1995-03-28 2001-06-12 Sonometrics Corporation Method for carrying out a medical procedure using a three-dimensional tracking and imaging system
US6171326B1 (en) 1998-08-27 2001-01-09 Micrus Corporation Three dimensional, low friction vasoocclusive coil, and method of manufacture
DE69631884T2 (en) 1995-07-12 2005-03-10 Valtion Teknillinen Tutkimuskeskus THERMOPLASTIFIED STARCH AND METHOD OF MANUFACTURING THEREOF
US6256529B1 (en) 1995-07-26 2001-07-03 Burdette Medical Systems, Inc. Virtual reality 3D visualization for surgical procedures
US5906574A (en) 1995-10-06 1999-05-25 Kan; William C. Apparatus for vacuum-assisted handling and loading of radioactive seeds and spacers into implant needles within an enclosed visible radiation shield for use in therapeutic radioactive seed implantation
GB9522403D0 (en) 1995-11-01 1996-01-03 Hoechst Roussel Ltd Intravaginal drug delivery device
US5833593A (en) 1995-11-09 1998-11-10 United States Surgical Corporation Flexible source wire for localized internal irradiation of tissue
US5713828A (en) 1995-11-27 1998-02-03 International Brachytherapy S.A Hollow-tube brachytherapy device
US6589502B1 (en) 1995-11-27 2003-07-08 International Brachytherapy S.A. Radioisotope dispersed in a matrix for brachytherapy
WO1997022379A2 (en) 1995-12-18 1997-06-26 Kerisma Medical Products, L.L.C. Fiberoptic-guided interstitial seed manual applicator and seed cartridge
US5640705A (en) 1996-01-16 1997-06-17 Koruga; Djuro L. Method of containing radiation using fullerene molecules
IT1282585B1 (en) 1996-02-08 1998-03-31 Europ POLYESTEREPOLYCARBONATE BLOCK COPOLYMERS CONTAINING SEGMENTS OF POLES (CAPROLACTONE) AND THEIR USE FOR THE PREPARATION OF MATRICES
JP3856504B2 (en) 1996-02-21 2006-12-13 独立行政法人理化学研究所 Ultraviolet region electroluminescence device, laser light emitting device, and method for manufacturing the same
US5761877A (en) 1996-02-23 1998-06-09 Quandt; W. Gerald System for individual dosage medication distribution
US6241962B1 (en) 1996-06-24 2001-06-05 Dupont Pharmaceuticals Company Radiopharmaceutical compositions and matrices and uses thereof
NL1003542C2 (en) 1996-07-08 1998-01-12 Optische Ind Oede Oude Delftoe Needle kit for brachytherapy.
US6416960B1 (en) 1996-08-08 2002-07-09 Prolume, Ltd. Detection and visualization of neoplastic tissues and other tissues
US5902310A (en) * 1996-08-12 1999-05-11 Ethicon Endo-Surgery, Inc. Apparatus and method for marking tissue
US6174329B1 (en) 1996-08-22 2001-01-16 Advanced Cardiovascular Systems, Inc. Protective coating for a stent with intermediate radiopaque coating
WO1998008533A1 (en) * 1996-08-30 1998-03-05 Peptech Limited Sustained peptide-release formulation
US5860909A (en) * 1996-10-18 1999-01-19 Mick Radio Nuclear Instruments, Inc. Seed applicator for use in radiation therapy
US5755704A (en) * 1996-10-29 1998-05-26 Medtronic, Inc. Thinwall guide catheter
US5871437A (en) 1996-12-10 1999-02-16 Inflow Dynamics, Inc. Radioactive stent for treating blood vessels to prevent restenosis
US6039684A (en) * 1997-12-11 2000-03-21 Allegheny University Of The Health Sciences Non-lethal conditioning methods for the treatment of acquired immunodeficiency syndrome
FI965067A0 (en) 1996-12-17 1996-12-17 Jvs Polymers Oy Implantmaterial som kan plastiseras
US6586859B2 (en) 2000-04-05 2003-07-01 Sri International Electroactive polymer animated devices
US6545384B1 (en) * 1997-02-07 2003-04-08 Sri International Electroactive polymer devices
US6312374B1 (en) 1997-03-06 2001-11-06 Progenix, Llc Radioactive wire placement catheter
US5976067A (en) 1997-05-28 1999-11-02 Ablation Technologies, Inc. Combination radioactive and temperature self-regulating thermal seed implant for treating tumors
DE19723895C2 (en) 1997-06-06 1999-06-02 Yoon Jick Dipl Ing Lee Biodegradable polyester urethanes, process for their preparation and their use
WO1998058698A1 (en) 1997-06-20 1998-12-30 Akzo Nobel N.V. Preloaded implantation device
DE19729459C2 (en) 1997-07-10 1999-07-29 Winter & Ibe Olympus Endoscopic, surgical device
US6340367B1 (en) * 1997-08-01 2002-01-22 Boston Scientific Scimed, Inc. Radiopaque markers and methods of using the same
US6174330B1 (en) * 1997-08-01 2001-01-16 Schneider (Usa) Inc Bioabsorbable marker having radiopaque constituents
US6440058B1 (en) 1997-08-01 2002-08-27 North American Scientific, Inc. Radioactive seeds and method for using same
US6503186B1 (en) 1997-08-01 2003-01-07 North American Scientific, Inc. Radioactive seed with multiple markers and method for using same
US6077880A (en) 1997-08-08 2000-06-20 Cordis Corporation Highly radiopaque polyolefins and method for making the same
JPH1178540A (en) 1997-09-09 1999-03-23 Nishikawa Rubber Co Ltd Weather strip
JP3559902B2 (en) 1997-10-06 2004-09-02 グンゼ株式会社 Artificial dura and method for producing artificial dura
US6007474A (en) 1997-10-20 1999-12-28 Ablation Technologies, Inc. Radioactive and/or thermal seed implantation device
US6030333A (en) * 1997-10-24 2000-02-29 Radiomed Corporation Implantable radiotherapy device
US6419621B1 (en) * 1997-10-24 2002-07-16 Radiomed Corporation Coiled brachytherapy device
ATE504561T1 (en) 1997-11-07 2011-04-15 Univ Rutgers RADIO-DENSIVE POLYMERIC BIOMATERIALS
JP2001523651A (en) 1997-11-14 2001-11-27 デュポン ファーマシューティカルズ カンパニー Method for selective oxidation of organic compounds
US6129670A (en) 1997-11-24 2000-10-10 Burdette Medical Systems Real time brachytherapy spatial registration and visualization system
US6159165A (en) 1997-12-05 2000-12-12 Micrus Corporation Three dimensional spherical micro-coils manufactured from radiopaque nickel-titanium microstrand
US6561967B2 (en) 1997-12-12 2003-05-13 Bruno Schmidt Interstitial brachytherapy device and method
US6213932B1 (en) * 1997-12-12 2001-04-10 Bruno Schmidt Interstitial brachytherapy device and method
US6197324B1 (en) 1997-12-18 2001-03-06 C. R. Bard, Inc. System and methods for local delivery of an agent
US5938583A (en) 1997-12-29 1999-08-17 Grimm; Peter D. Precision implant needle and method of using same in seed implant treatment of prostate cancer
US6027446A (en) * 1998-01-12 2000-02-22 Washington Univ. Of Office Of Technology Transfer Pubic arch detection and interference assessment in transrectal ultrasound guided prostate cancer therapy
US6011473A (en) * 1998-01-13 2000-01-04 Micron Electronics, Inc. Method for generating an alarm in a portable computer system
JP2002502676A (en) 1998-02-12 2002-01-29 ロバート、ロバートソン Low energy brachytherapy source with capsules
EP0938894A1 (en) 1998-02-16 1999-09-01 Biomat B.V. Implantable radiopaque device and use thereof
US6540693B2 (en) 1998-03-03 2003-04-01 Senorx, Inc. Methods and apparatus for securing medical instruments to desired locations in a patients body
US6360116B1 (en) * 1998-02-27 2002-03-19 Varian Medical Systems, Inc. Brachytherapy system for prostate cancer treatment with computer implemented systems and processes to facilitate pre-operative planning and post-operative evaluations
US6327490B1 (en) * 1998-02-27 2001-12-04 Varian Medical Systems, Inc. Brachytherapy system for prostate cancer treatment with computer implemented systems and processes to facilitate pre-implantation planning and post-implantation evaluations with storage of multiple plan variations for a single patient
US5928130A (en) 1998-03-16 1999-07-27 Schmidt; Bruno Apparatus and method for implanting radioactive seeds in tissue
US5997463A (en) 1998-03-26 1999-12-07 North American Scientific Laser welded brachytherapy source and method of making the same
ATE388224T1 (en) 1998-03-27 2008-03-15 Prolume Ltd LUCIFERASE, GFP FLUORESCENT PROTEINS, CODING NUCLEIC ACID AND THEIR USE IN DIAGNOSTICS
DE19815568C2 (en) 1998-03-31 2000-06-08 Bebig Isotopentechnik Und Umwe Process for the production of medical radioactive ruthenium radiation sources by electrolytic deposition of radioactive ruthenium on a carrier, radiation sources produced with this process and electrolysis cell for producing radioactive ruthenium layers
JP2002510656A (en) * 1998-04-03 2002-04-09 デュポン ファーマシューティカルズ カンパニー Inorganic substances for radiopharmaceutical delivery systems
GB9808052D0 (en) 1998-04-17 1998-06-17 Secr Defence Implants for administering substances and methods of producing implants
US6311084B1 (en) 1998-05-04 2001-10-30 Robert A. Cormack Radiation seed implant method and apparatus
US6010446A (en) * 1998-05-20 2000-01-04 Grimm; Peter D. Spacer element for radioactive seed implant treatment of prostate cancer
US6086942A (en) 1998-05-27 2000-07-11 International Brachytherapy S.A. Fluid-jet deposition of radioactive material for brachytherapy devices
US6053858A (en) * 1998-06-04 2000-04-25 Advanced Cardiovascular Systems, Inc. Radiation source
US6159143A (en) * 1998-06-17 2000-12-12 Scimed Life Systems, Inc. Method and device for delivery of therapeutic agents in conjunction with isotope seed placement
US6171297B1 (en) 1998-06-30 2001-01-09 Schneider (Usa) Inc Radiopaque catheter tip
WO2000004953A2 (en) * 1998-07-20 2000-02-03 Cook Urological Inc. Brachytherapy device including an anti-static handle
WO2000005349A1 (en) 1998-07-21 2000-02-03 Unilever N.V. Phenol oxidizing enzymes
DE69938501D1 (en) 1998-07-24 2008-05-21 Oklahoma Med Res Found USE OF PROHIBITIN RNA IN CANCER TREATMENT
WO2000006243A2 (en) 1998-07-28 2000-02-10 Innerdyne, Inc. Absorbable brachytherapy and chemotherapy delivery devices and methods
US6080099A (en) 1998-08-12 2000-06-27 Syntheon, Llc Radioactive therapeutic seeds
US6007475A (en) 1998-08-12 1999-12-28 Cns Technology, Inc. Radioactive therapeutic seeds
US6387034B1 (en) 1998-08-17 2002-05-14 Georia Tech Research Corporation Brachytherapy treatment planning method and apparatus
US20010047185A1 (en) 1998-08-22 2001-11-29 Stanley Satz Radioactivatable composition and implantable medical devices formed therefrom
IL126341A0 (en) 1998-09-24 1999-05-09 Medirad I R T Ltd Radiation delivery devices and methods of making same
US6496717B2 (en) 1998-10-06 2002-12-17 University Of South Florida Radio guided seed localization of imaged lesions
EP0993843B1 (en) 1998-10-14 2006-04-26 Terumo Kabushiki Kaisha Radiation source delivery wire and catheter assembly for radiation therapy
US6200255B1 (en) * 1998-10-30 2001-03-13 University Of Rochester Prostate implant planning engine for radiotherapy
CA2345620A1 (en) 1998-11-06 2000-05-18 Nycomed Amersham Plc Products and methods for brachytherapy
US6689043B1 (en) * 1998-11-06 2004-02-10 Amersham Plc Products and methods for brachytherapy
WO2000028598A1 (en) * 1998-11-10 2000-05-18 Biocrystal Limited Methods for identification and verification
DE69925629T2 (en) 1998-11-20 2006-05-04 Amersham Health As PROCESS AND DEVICE FOR WELDING
US6066083A (en) 1998-11-27 2000-05-23 Syntheon Llc Implantable brachytherapy device having at least partial deactivation capability
US6471631B1 (en) 1998-11-27 2002-10-29 Syntheon, Llc Implantable radiation therapy device having controllable radiation emission
EP1135165A1 (en) 1998-12-03 2001-09-26 Boston Scientific Limited Stent having drug crystals thereon
CA2320097C (en) 1998-12-09 2009-04-14 Cook Incorporated Hollow, curved, superelastic medical needle
CA2292189A1 (en) 1998-12-31 2000-06-30 Ethicon, Inc. Radiopaque polymer blend
US6132359A (en) 1999-01-07 2000-10-17 Nycomed Amersham Plc Brachytherapy seeds
AR022404A1 (en) 1999-01-25 2002-09-04 Photogen Inc METHOD AND AGENTS FOR IMPROVED RADIATION THERAPY
US6368331B1 (en) * 1999-02-22 2002-04-09 Vtarget Ltd. Method and system for guiding a diagnostic or therapeutic instrument towards a target region inside the patient's body
ES2284481T3 (en) 1999-02-25 2007-11-16 Ge Healthcare Limited TOOLS AND MEDICAL DEVICES WITH AN IMPROVED ULTRASOUND VISIBILITY.
US6200258B1 (en) * 1999-08-10 2001-03-13 Syntheon, Llc Radioactive therapeutic seed having selective marker configuration
PT1156827E (en) 1999-03-01 2007-01-31 Halogenetics Inc Use of compositions comprising cldc as radiosensitizers in the treatment of neoplastic diseases
US6132947A (en) 1999-03-10 2000-10-17 Eastman Kodak Company Cyan coupler, and stabilizer-containing photographic element and process
US6200256B1 (en) * 1999-03-17 2001-03-13 The Trustees Of Columbia University In The City Of New York Apparatus and method to treat a disease process in a luminal structure
ATE470402T1 (en) 1999-04-08 2010-06-15 Synergetics Inc DIRECTED LASER PROBE
WO2000061229A1 (en) 1999-04-09 2000-10-19 Medi Physics, Inc. Method and apparatus for loading delivery systems for brachytherapy seeds
US6132677A (en) 1999-04-26 2000-10-17 Lockheed Martin Energy Research Corporation Method for making radioactive metal articles having small dimensions
WO2000064538A1 (en) 1999-04-28 2000-11-02 Medi Physics, Inc. Products and methods for brachytherapy
DE29908415U1 (en) 1999-05-18 1999-07-22 Carl Agents for the treatment of local periodontal infections
US6426145B1 (en) 1999-05-20 2002-07-30 Scimed Life Systems, Inc. Radiopaque compositions for visualization of medical devices
US6482178B1 (en) 1999-05-21 2002-11-19 Cook Urological Incorporated Localization device with anchoring barbs
JP3074170B1 (en) 1999-05-27 2000-08-07 大澤 映二 Manufacturing method of nano-sized spherical graphite
MXPA02000375A (en) 1999-07-14 2002-07-30 Novoste Corp Radioactive source train.
US6595908B2 (en) 1999-07-23 2003-07-22 Nucletron B.V. Method for analyzing amount of activity
US6267718B1 (en) 1999-07-26 2001-07-31 Ethicon, Endo-Surgery, Inc. Brachytherapy seed cartridge
US6221003B1 (en) 1999-07-26 2001-04-24 Indigo Medical, Incorporated Brachytherapy cartridge including absorbable and autoclaveable spacer
US6264599B1 (en) * 1999-08-10 2001-07-24 Syntheon, Llc Radioactive therapeutic seeds having fixation structure
JP4172883B2 (en) 1999-09-08 2008-10-29 Ｈｏｙａ株式会社 Drug sustained release carrier and method for producing drug sustained release carrier
DE19946606B4 (en) 1999-09-29 2013-07-04 Robert Bosch Gmbh Apparatus for forming an air-fuel mixture for an internal combustion engine during a warm-up phase
AU8026600A (en) 1999-10-15 2001-04-30 Deschutes Medical Products, Inc. Brachytherapy instrument and methods
US6398709B1 (en) 1999-10-19 2002-06-04 Scimed Life Systems, Inc. Elongated member for intravascular delivery of radiation
DE19950646A1 (en) 1999-10-21 2001-05-03 Merck Patent Gmbh Colored materials made from biodegradable polymers in the medical-pharmacological field
US6264600B1 (en) 1999-10-21 2001-07-24 Peter D. Grimm Hollow suture member with radioactive seeds positioned therein for treatment of prostate cancer
US6436026B1 (en) 1999-10-22 2002-08-20 Radiomed Corporation Flexible, continuous, axially elastic interstitial brachytherapy source
CA2398832A1 (en) 1999-11-09 2002-08-12 Forschungszentrum Karlsruhe Gmbh Mixture containing rare earths and use thereof
WO2001036007A2 (en) 1999-11-12 2001-05-25 Angiotech Pharmaceuticals, Inc. Compositions of a combination of radioactive therapy and cell-cycle inhibitors
US6450937B1 (en) 1999-12-17 2002-09-17 C. R. Bard, Inc. Needle for implanting brachytherapy seeds
US6402677B1 (en) 1999-12-17 2002-06-11 C.R. Bard, Inc. Brachytherapy seed needle with window
FR2803304B1 (en) 1999-12-29 2006-03-24 Ceca Sa INORGANIC DEPOSIT INHIBITORS, ESPECIALLY IN OIL WELLS
US6355058B1 (en) 1999-12-30 2002-03-12 Advanced Cardiovascular Systems, Inc. Stent with radiopaque coating consisting of particles in a binder
JP2003519266A (en) 2000-01-05 2003-06-17 ケンブリッジ ディスプレイ テクノロジー リミテッド Polymers for luminescence
US6575888B2 (en) * 2000-01-25 2003-06-10 Biosurface Engineering Technologies, Inc. Bioabsorbable brachytherapy device
DE10004832A1 (en) 2000-01-31 2001-08-16 Ethicon Gmbh Flat implant with X-ray visible elements
SE0000363L (en) 2000-02-04 2001-08-05 Zoucas Kirurgkonsult Ab Coated medical device
US6350244B1 (en) * 2000-02-21 2002-02-26 Biopsy Sciences, Llc Bioabsorable markers for use in biopsy procedures
US6358195B1 (en) * 2000-03-09 2002-03-19 Neoseed Technology Llc Method and apparatus for loading radioactive seeds into brachytherapy needles
US6846283B2 (en) * 2000-03-09 2005-01-25 Neoseed Technology Llc Methods and apparatus for loading radioactive seeds into brachytherapy needles
FI20000572A (en) 2000-03-13 2001-09-14 Leiras Oy Device intended for application of implants
US6450938B1 (en) 2000-03-21 2002-09-17 Promex, Llc Brachytherapy device
DE10014518A1 (en) 2000-03-23 2001-10-04 Aventis Pharma Gmbh Device for applying implants
US6428504B1 (en) 2000-04-06 2002-08-06 Varian Medical Systems, Inc. Multipurpose template and needles for the delivery and monitoring of multiple minimally invasive therapies
US6438401B1 (en) 2000-04-28 2002-08-20 Alpha Intervention Technology, Inc. Indentification and quantification of needle displacement departures from treatment plan
US6403916B1 (en) 2000-05-12 2002-06-11 Isostar International, Inc. System and automated method for producing welded end closures in thin-walled metal tubes
GB0011581D0 (en) 2000-05-15 2000-07-05 Nycomed Amersham Plc Grooved brachytherapy
US6749553B2 (en) * 2000-05-18 2004-06-15 Theragenics Corporation Radiation delivery devices and methods for their manufacture
US6616594B2 (en) 2000-05-18 2003-09-09 Integrated Implant Systems, L.L.C. Cartridge-moveable shield
US6572525B1 (en) 2000-05-26 2003-06-03 Lisa Yoshizumi Needle having an aperture for detecting seeds or spacers loaded therein and colored seeds or spacers
US6616593B1 (en) 2000-06-05 2003-09-09 Mentor Corporation Automated radioisotope seed cartridge
US6537192B1 (en) * 2000-06-05 2003-03-25 Mentor Corporation Automated radioisotope seed loader system for implant needles
MXPA03000528A (en) * 2000-07-17 2004-09-10 Medi Physics Inc Carrier-free 103.
US6500109B2 (en) 2000-07-21 2002-12-31 Tayman Medical, Inc. Prostate treatment template
NL1016101C2 (en) * 2000-09-05 2002-03-07 Nucletron Bv Row of radioactive seeds and non-radioactive spacers and connecting element therefor.
US6805898B1 (en) 2000-09-28 2004-10-19 Advanced Cardiovascular Systems, Inc. Surface features of an implantable medical device
AU2002215333A1 (en) 2000-10-12 2002-04-22 Guilford Pharmaceuticals Inc. Compositions for release of radiosensitizers, and methods of making and using the same
US6949064B2 (en) 2000-10-20 2005-09-27 Bard Brachytherapy, Inc. Brachytherapy seed deployment system
IL139266A0 (en) 2000-10-25 2001-11-25 Yeda Res & Dev A method and apparatus for producing inorganic fullerene-like nanoparticles
WO2003028808A2 (en) * 2000-10-25 2003-04-10 Lamoureux Gary A Pre-loaded needle assembly
PL203978B1 (en) 2000-11-01 2009-11-30 Medi Physics Inc Radioactive member and method of making
US6450939B1 (en) 2000-11-06 2002-09-17 Peter D. Grimm Hinged spacer element for joining radioactive seeds used in treatment of cancer
WO2002038199A2 (en) 2000-11-08 2002-05-16 Theragenics Corporation Radioactive source wire and delivery catheter for brachytherapy
US6612976B2 (en) 2000-11-13 2003-09-02 Isotech, L.L.C. Radioactive medical devices and methods of making radioactive medical devices
US6926657B1 (en) 2000-11-14 2005-08-09 Medi-Physics, Inc. Device for loading radioactive seeds
WO2004026111A2 (en) 2000-11-16 2004-04-01 Microspherix Llc Flexible and/or elastic brachytherapy seed or strand
WO2002068000A2 (en) * 2000-11-16 2002-09-06 Microspherix Llc Polymeric imagable brachytherapy seed
US6746661B2 (en) 2000-11-16 2004-06-08 Microspherix Llc Brachytherapy seed
US6638205B1 (en) 2000-11-17 2003-10-28 Mds (Canada) Inc. Radioactive medical device for radiation therapy
ATE337804T1 (en) 2000-11-21 2006-09-15 Schering Ag TUBULAR VESSEL IMPLANTS (STENTS) AND METHOD FOR THE PRODUCTION THEREOF
DE10058163C2 (en) 2000-11-22 2003-07-10 Bebig Isotopen Und Medizintech Method and applicator for positioning and / or ejecting radiation sources via hollow needles into biological tissue
US6719242B2 (en) * 2000-12-01 2004-04-13 Sonoco Development, Inc. Composite core
US20020077687A1 (en) 2000-12-14 2002-06-20 Ahn Samuel S. Catheter assembly for treating ischemic tissue
US6472675B2 (en) 2000-12-15 2002-10-29 Theragenics Corporation Container for storing and shipping needle cartridges
US6723037B2 (en) * 2000-12-15 2004-04-20 Kawasumi Laboratories, Inc. Protective tool for therapeutic material delivery device, cartridge for therapeutic material delivery device, and a therapeutic material delivery device
EP1232770A1 (en) * 2001-02-15 2002-08-21 AEA Technology QSA GmbH Radioactive capsule seed
US6800055B2 (en) 2001-02-21 2004-10-05 Cordis Corporation Low attenuating radioactive seeds
US6572527B2 (en) 2001-02-23 2003-06-03 Mentor Corporation Radioactive seed-holding device
US6669621B2 (en) 2001-03-14 2003-12-30 Cordis Corporation Method and assembly for containing radioactive materials
US6497646B1 (en) 2001-03-14 2002-12-24 Cordis Corporation Intravascular radiotherapy source ribbon having variable radiopacity
US20020138136A1 (en) 2001-03-23 2002-09-26 Scimed Life Systems, Inc. Medical device having radio-opacification and barrier layers
US6726617B1 (en) * 2001-04-09 2004-04-27 Bruno Schmidt Cartridge and applicator
US20020169354A1 (en) * 2001-05-10 2002-11-14 Munro John J. Brachytherapy systems and methods
JP4901021B2 (en) 2001-06-06 2012-03-21 川澄化学工業株式会社 Catheter tube
US6549802B2 (en) * 2001-06-07 2003-04-15 Varian Medical Systems, Inc. Seed localization system and method in ultrasound by fluoroscopy and ultrasound fusion
US6723052B2 (en) * 2001-06-07 2004-04-20 Stanley L. Mills Echogenic medical device
US6645391B2 (en) * 2001-07-13 2003-11-11 Hazard Control Technologies Visibility enhancement composition
US8267995B2 (en) * 2001-08-03 2012-09-18 David Castillejos Method and intra sclera implant for treatment of glaucoma and presbyopia
US6656106B2 (en) 2001-08-17 2003-12-02 Bruno Schmidt Device for checking seeds in brachytherapy needle
US6755775B2 (en) 2001-08-30 2004-06-29 North American Scientific, Inc. Apparatus and method for loading a brachytherapy seed cartridge
US6911219B2 (en) 2001-09-27 2005-06-28 Surgica Corporation Partially acetalized polyvinyl alcohol embolization particles, compositions containing those particles and methods of making and using them
US6639237B2 (en) 2001-11-02 2003-10-28 Mentor Corporation Brachytherapy medical devices
US7094198B2 (en) 2001-11-02 2006-08-22 Worldwide Medical Technologies, Llc Delivery system and method for interstitial radiation therapy using seed elements with ends having one of projections and indentations
US6761680B2 (en) 2001-11-02 2004-07-13 Richard A. Terwilliger Delivery system and method for interstitial radiation therapy using seed strands constructed with preformed strand housing
US6820318B2 (en) 2001-11-02 2004-11-23 Ideamatrix, Inc. System for manufacturing interstitial radiation therapy seed strands
US7074291B2 (en) 2001-11-02 2006-07-11 Worldwide Medical Technologies, L.L.C. Delivery system and method for interstitial radiation therapy using strands constructed with extruded strand housings
US6786858B2 (en) 2001-11-02 2004-09-07 Ideamatrix, Inc. Delivery system and method for interstitial radiotherapy using hollow seeds
US7060020B2 (en) 2001-11-02 2006-06-13 Ideamatrix, Inc. Delivery system and method for interstitial radiation therapy
KR100453130B1 (en) 2001-11-21 2004-10-15 한국과학기술연구원 Sequentially Ordered Biodegradable Lactide(Glycolide or Lactide/Glycolide)/ε-Caprolactone Multi-Block Copolymer and Process for the Preparation Thereof
US7462325B2 (en) 2001-11-30 2008-12-09 Nomadics, Inc. Luminescent polymer particles
AUPR951501A0 (en) 2001-12-14 2002-01-24 Smart Drug Systems Inc Modified sustained release pharmaceutical system
US20030129311A1 (en) 2002-01-10 2003-07-10 Wen-Chiang Huang Method of producing quantum-dot powder and film via templating by a 2-d ordered array of air bubbles in a polymer
AU2003216103A1 (en) 2002-01-25 2003-09-02 Mick Radio-Nuclear Instruments, Inc. Disposable and shielded seed and spacer magazine
CA2474359A1 (en) 2002-01-29 2003-08-07 Sicel Technologies, Inc. Implantable sensor housing and fabrication methods
DE10204818C2 (en) 2002-02-06 2003-11-27 Eurotope Entwicklungsgesellsch Device and method for loading implantation needles with radiation sources from radiation source chains for interstitial brachytherapy of tissue
EP1334990A1 (en) 2002-02-06 2003-08-13 Polyganics B.V. DL-Lactide-epsilon-caprolactone copolymers
US6887270B2 (en) 2002-02-08 2005-05-03 Boston Scientific Scimed, Inc. Implantable or insertable medical device resistant to microbial growth and biofilm formation
US8133501B2 (en) 2002-02-08 2012-03-13 Boston Scientific Scimed, Inc. Implantable or insertable medical devices for controlled drug delivery
US7462366B2 (en) 2002-03-29 2008-12-09 Boston Scientific Scimed, Inc. Drug delivery particle
IL148994A (en) * 2002-04-04 2009-02-11 Shai Amisar Intravenous catheter assembly
US20030191355A1 (en) 2002-04-04 2003-10-09 Ferguson Patrick J. Hollow bioabsorbable elements for positioning material in living tissue
US6837844B1 (en) * 2002-05-14 2005-01-04 Med-Tec Iowa, Inc. Seed cartridge for radiation therapy
US6656107B1 (en) 2002-05-24 2003-12-02 Mentor Corporation Brachytherapy seed applicators
NL1020740C2 (en) 2002-06-03 2003-12-08 Nucletron Bv Method and device for the temporary introduction and placement of at least one energy-emitting source in an animal body.
JP3725101B2 (en) * 2002-07-31 2005-12-07 株式会社東芝 Information recording method and information recording apparatus
EP1551509B1 (en) 2002-09-10 2008-10-29 Cianna Medical, Inc. Brachytherapy apparatus
US20060121080A1 (en) 2002-11-13 2006-06-08 Lye Whye K Medical devices having nanoporous layers and methods for making the same
US6969344B2 (en) 2003-02-10 2005-11-29 Bard Brachytherapy, Inc. End portion of first implantation seed spacer that receives and holds any one of implantation seed and second implantation seed spacer
US20040158118A1 (en) 2003-02-10 2004-08-12 Drobnik Christopher D. Terminus-spacer component of a string comprising one or more spacer components and one or more implantation seeds
US7322928B2 (en) * 2003-03-17 2008-01-29 Medi-Physics, Inc. Products and methods for brachytherapy
US7214206B2 (en) 2003-04-03 2007-05-08 Valera Pharmaceuticals, Inc. Implanting device and method of using same
US20040224000A1 (en) 2003-05-05 2004-11-11 Romano Deghenghi Implants for non-radioactive brachytherapy of hormonal-insensitive cancers
US6989543B2 (en) * 2003-08-15 2006-01-24 C.R. Bard, Inc. Radiation shielding container for radioactive sources
CA2577665C (en) 2003-08-20 2013-03-26 International Brachytherapy, S.A. Plastic brachytherapy sources
DE10355087A1 (en) 2003-11-24 2005-06-09 Basf Ag Process for the electrochemical preparation of a crystalline porous organometallic framework
TWI434676B (en) 2004-03-19 2014-04-21 Merck Sharp & Dohme X-ray visible drug delivery device
WO2005115543A1 (en) 2004-05-20 2005-12-08 Wisconsin Alumni Research Foundation Directionally emitting radioactive sources for brachytherapy
US7425195B2 (en) * 2004-08-13 2008-09-16 Core Oncology, Inc. Radiation shielding device
KR20070104574A (en) 2004-12-30 2007-10-26 신벤션 아게 Combination comprising an agent providing a signal, an implant material and a drug
US8888745B2 (en) 2005-01-24 2014-11-18 Merck Sharp & Dohme B.V. Applicator for inserting an implant
SI3417905T2 (en) 2005-01-24 2023-11-30 Merck Sharp & Dohme B.V. Applicator for inserting an implant
USD551759S1 (en) 2005-06-13 2007-09-25 N. V. Organon Applicator for inserting an implant
JP5042029B2 (en) 2005-10-18 2012-10-03 オリンパス株式会社 Endoscopic treatment tool
US20070270781A1 (en) 2006-01-06 2007-11-22 Robert Burgermeister Medical delivery system and method for delivery of a medically useful payload
EP1984063B1 (en) 2006-01-19 2019-08-14 Merck Sharp & Dohme B.V. Kit for and method of assembling an applicator for inserting an implant
US8170647B2 (en) 2006-01-20 2012-05-01 Best Medical International, Inc Fiduciary markers and method of use thereof
US20070224234A1 (en) 2006-03-22 2007-09-27 Mark Steckel Medical devices having biodegradable polymeric regions
EP2125098B1 (en) 2007-02-28 2012-09-26 C.R.Bard, Inc. Brachytherapy element transfer system
JP5446701B2 (en) 2009-10-06 2014-03-19 株式会社三洋物産 Game machine

Also Published As

Publication number Publication date
US8821835B2 (en) 2014-09-02
JP2006500115A (en) 2006-01-05
US20100261946A1 (en) 2010-10-14
US20150238661A1 (en) 2015-08-27
AU2003267309A1 (en) 2004-04-08
US7776310B2 (en) 2010-08-17
EP1545705A4 (en) 2010-04-28
WO2004026111A3 (en) 2004-07-01
US20170216499A1 (en) 2017-08-03
EP1545705A2 (en) 2005-06-29
US10493181B2 (en) 2019-12-03
US20040109823A1 (en) 2004-06-10
US20200093968A1 (en) 2020-03-26
AU2003267309A8 (en) 2004-04-08
US10994058B2 (en) 2021-05-04
US20150010470A1 (en) 2015-01-08
US9636401B2 (en) 2017-05-02
US9636402B2 (en) 2017-05-02
US20130280168A1 (en) 2013-10-24
WO2004026111A2 (en) 2004-04-01
US20180050134A2 (en) 2018-02-22
US8470294B2 (en) 2013-06-25

Similar Documents

Publication Publication Date Title
WO2004026111B1 (en) Flexible and/or elastic brachytherapy seed or strand
KR102114984B1 (en) Micro needle Using the Bioabsorbable Metal
US6746661B2 (en) Brachytherapy seed
US6248057B1 (en) Absorbable brachytherapy and chemotherapy delivery devices and methods
US4674480A (en) Drug compositions and methods of applying same
US20020133225A1 (en) Methods and apparatuses for delivering a medical agent to a medical implant
CN1905913B (en) Implant for releasing an active substance into a vessel through which a body medium flows
US20040254419A1 (en) Therapeutic assembly
EP0706784A1 (en) Stent which can be implanted into a body vessel
CN105979978A (en) Functionalized Lubricious Medical Device Coatings
CN103736201B (en) A kind of radioactive particle chain
US20120108882A1 (en) Brachytherapy Devices and Related Methods Providing Bioaborbability and/or Asymmetric Irradiation
CN205832384U (en) A kind of radioactive prospecting instrument pin
CN108030997A (en) Adj sp medicine delivery implantable device
WO2002068000A3 (en) Polymeric imagable brachytherapy seed
Ghoneim Applications of Nano-Ferrites in Medicine
Rao et al. Asian Journal of Research in Chemistry and Pharmaceutical Sciences

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NI NO NZ OM PG PH PL PT RO RU SC SD SE SG SK SL SY TJ TM TN TR TT TZ UA UG UZ VC VN YU ZA ZM ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZM ZW AM AZ BY KG KZ MD RU TJ TM AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LU MC NL PT RO SE SI SK TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
B Later publication of amended claims

Effective date: 20040712

WWE Wipo information: entry into national phase

Ref document number: 2004538328

Country of ref document: JP

WWE Wipo information: entry into national phase

Ref document number: 2003749783

Country of ref document: EP

WWP Wipo information: published in national office

Ref document number: 2003749783

Country of ref document: EP