WO2003009051A2 - Accommodative intraocular lens - Google Patents
Accommodative intraocular lens Download PDFInfo
- Publication number
- WO2003009051A2 WO2003009051A2 PCT/US2002/022785 US0222785W WO03009051A2 WO 2003009051 A2 WO2003009051 A2 WO 2003009051A2 US 0222785 W US0222785 W US 0222785W WO 03009051 A2 WO03009051 A2 WO 03009051A2
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- WIPO (PCT)
- Prior art keywords
- lens
- component
- intraocular lens
- eye
- optical
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/14—Eye parts, e.g. lenses, corneal implants; Implanting instruments specially adapted therefor; Artificial eyes
- A61F2/16—Intraocular lenses
- A61F2/1613—Intraocular lenses having special lens configurations, e.g. multipart lenses; having particular optical properties, e.g. pseudo-accommodative lenses, lenses having aberration corrections, diffractive lenses, lenses for variably absorbing electromagnetic radiation, lenses having variable focus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/14—Eye parts, e.g. lenses, corneal implants; Implanting instruments specially adapted therefor; Artificial eyes
- A61F2/16—Intraocular lenses
- A61F2/1613—Intraocular lenses having special lens configurations, e.g. multipart lenses; having particular optical properties, e.g. pseudo-accommodative lenses, lenses having aberration corrections, diffractive lenses, lenses for variably absorbing electromagnetic radiation, lenses having variable focus
- A61F2/1624—Intraocular lenses having special lens configurations, e.g. multipart lenses; having particular optical properties, e.g. pseudo-accommodative lenses, lenses having aberration corrections, diffractive lenses, lenses for variably absorbing electromagnetic radiation, lenses having variable focus having adjustable focus; power activated variable focus means, e.g. mechanically or electrically by the ciliary muscle or from the outside
- A61F2/1629—Intraocular lenses having special lens configurations, e.g. multipart lenses; having particular optical properties, e.g. pseudo-accommodative lenses, lenses having aberration corrections, diffractive lenses, lenses for variably absorbing electromagnetic radiation, lenses having variable focus having adjustable focus; power activated variable focus means, e.g. mechanically or electrically by the ciliary muscle or from the outside for changing longitudinal position, i.e. along the visual axis when implanted
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/14—Eye parts, e.g. lenses, corneal implants; Implanting instruments specially adapted therefor; Artificial eyes
- A61F2/16—Intraocular lenses
- A61F2/1613—Intraocular lenses having special lens configurations, e.g. multipart lenses; having particular optical properties, e.g. pseudo-accommodative lenses, lenses having aberration corrections, diffractive lenses, lenses for variably absorbing electromagnetic radiation, lenses having variable focus
- A61F2/1648—Multipart lenses
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29D—PRODUCING PARTICULAR ARTICLES FROM PLASTICS OR FROM SUBSTANCES IN A PLASTIC STATE
- B29D11/00—Producing optical elements, e.g. lenses or prisms
- B29D11/02—Artificial eyes from organic plastic material
- B29D11/023—Implants for natural eyes
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29D—PRODUCING PARTICULAR ARTICLES FROM PLASTICS OR FROM SUBSTANCES IN A PLASTIC STATE
- B29D11/00—Producing optical elements, e.g. lenses or prisms
- B29D11/02—Artificial eyes from organic plastic material
- B29D11/023—Implants for natural eyes
- B29D11/026—Comprising more than one lens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/0077—Special surfaces of prostheses, e.g. for improving ingrowth
- A61F2002/009—Special surfaces of prostheses, e.g. for improving ingrowth for hindering or preventing attachment of biological tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/14—Eye parts, e.g. lenses, corneal implants; Implanting instruments specially adapted therefor; Artificial eyes
- A61F2/16—Intraocular lenses
- A61F2002/1681—Intraocular lenses having supporting structure for lens, e.g. haptics
Definitions
- the present invention relates to accommodative intraocular lenses used to replace the aged human natural lens to provide multiple focuses by bidirectional shift of the lens optics along the eye's optical axis.
- the design of the present invention also prevents posterior chamber opacification, a condition normally associated with the removal of the natural human lens, which may lead to secondary cataract formation.
- the effective focal length of the eye In order for the human eye to have clear vision of objects at different distances, the effective focal length of the eye must be adjusted to keep the image of the object focused as sharply as possible on the retina. This change in effective focal length is known as accommodation and is accomplished in the eye by varying the shape of the crystalline lens.
- the curvature of the lens is such that distant objects are sharply imaged on the retina.
- near images are not focused sharply on the retina because the focal points of their images lie behind the retinal surface.
- the curvature of the crystalline lens In order to visualize a near object clearly, the curvature of the crystalline lens must be increased, thereby increasing its refractive power and causing the focal point of the near object to fall on the retina.
- the change in shape of the crystalline lens is accomplished by the action of certain muscles and structures within the eyeball or globe of the eye.
- the lens is located in the forward part of the eye, immediately behind the pupil. It has the shape of a biconvex optical lens, i.e., it has a generally circular cross-section of two-convex-refracting surfaces, and is located generally on the optical axis of the eye, i.e., a straight line drawn from the center of the cornea to the macula in the retina at the posterior portion of the globe.
- the curvature of the posterior surface of the lens i.e., the surface adjacent to the vitreous body, is somewhat greater than that of the anterior surface.
- the lens is closely surrounded by a membranous capsule that serves as an intermediate structure in the support and actuation of the lens.
- the lens and its capsule are suspended on the optical axis behind the pupil by a circular assembly of many radially-directed collagenous fibers, the zonules, which are attached at their inner ends to the lens capsule and at their outer ends to the ciliary body, a muscular ring of tissue located just within the outer supporting structure of the eye, the sclera.
- the ciliary body is relaxed in the unaccommodated eye and therefore assumes its largest diameter.
- the relatively large diameter of the ciliary body in this condition causes a tension on the zonules which in turn pull radially outward on the lens capsule, causing the equatorial diameter of the lens to increase slightly, and decreasing the anterior-posterior dimension of the lens at the optical axis.
- the tension on the lens capsule causes the lens to assume a flattened state wherein the curvature of the anterior surface, and to some extent of the posterior surface, is less than it would be in the absence of the tension.
- the refractive power of the lens is relatively low and the eye is focused for clear vision of distant objects, i.e., the unaccommodated state.
- zonules work like a spring with one end attached to the elastic lens and the other end attached to ciliary muscles.
- the spring In an unaccommodated state, the spring is pulled taut by the ciliary muscles to force the elastic lens to become thin; in an accommodated state, the spring relaxes to relieve the elastic lens so that it becomes thick (see Figures la and lb).
- the elastic lens In a young and healthy eye, the elastic lens can become thin (low diopter) or thick (high diopter) with about 3 diopters difference. Starting at age mid-forty, a typical eye begins to gradually lose its near distance vision (presbyopia). There are multiple reasons for loss of accommodation. One of them is that the human lens becomes too hard to change back and forth from a thin lens to a thick lens.
- the change in lens focus power measured in diopter is achieved by a bi-directional shift of the IOL guided by the hinge, along the optical axis.
- the more the shifting distance toward the anterior chamber the more the focus power for the lens.
- Gwon, in US Patent 6,176,878 (issued January 23, 2001), discloses an accommodating lens design which is adapted to cooperate with the eye to move the optic body bi- directionally, that is anteriorly or posteriorly in the eye.
- Israel in US Patent 6,013,101 (issued January 11, 2000), discloses another accommodating lens design with haptics in engagement with zonule movement to achieve a bi-directional shift of the lens along the optical axis.
- all of these prior art patents utilize various mechanisms to move the optical body of the IOL either anteriorly or posteriorly to achieve near vision, or far vision respectively.
- Sarfarazi in US Patent 5,275,623, issued January 4, 1994, discloses an elliptical accommodating IOL with two optical bodies positioned in the anterior surface and posterior surface respectively.
- the lens is a closed cell containing fluids. The accommodation is achieved by adjusting the distance between the two optical bodies of the elliptical IOL.
- Figure 2 is derived from US Patent 6,197,059, where the IOL is in the backward and forward positions, respectively.
- the gap between the IOL and posterior surface of the capsular bag in the forward position may invite the growth of epithelial cells so that eventually epithelial cells will occupy any existing space in the capsular bag. Consequently, that structure could lead to secondary cataract formation.
- the epithelial cell's in-growth into the gap may hinder and eventually prevent the IOL from shifting along the optical axis, thus resulting in a loss in accommodation once again.
- the present invention discloses a family of accommodating lenses designed to avoid secondary cataract formation while providing accommodating capabilities.
- the present invention provides an accommodative intraocular lens for replacing the aged human natural lens.
- the lens provides multiple focuses utilizing a bi-directional shift of the lens optics along the eye's optical axis.
- the lenses of the present invention also prevent posterior chamber opacification, a condition normally associated with the removal of the natural human lens which may lead to secondary cataract formation.
- These intraocular lenses comprise:
- a first component which consists of an optical body and a haptic body adjacent and attached to said optical body;
- a second component located posterior to said first component, which is structurally adapted to maintain substantial contact with the posterior surface of the capsular bag when implanted in the eye;
- the lens being configured so as to allow the first component to move forward and back relative to the second component, along the optical axis of the optical body.
- the accommodative lens structures may optimally include additional optional features, such as guiding grooves for assisting the bi-directional shift of the first component of the lens.
- the present invention also encompasses the method of implanting these accommodative lenses in the eye.
- Figure 1(a) is a schematic cutaway view of an eye in its unaccommodated state and Figure 1(b) is a schematic cutaway view of an eye in its accommodated state.
- Figure 2 is a side view of an example of an accommodative lens design from the prior art.
- Figure 3 is a schematic cutaway view of one embodiment of the present invention.
- Figure 4 is the isometric view of the lens of Figure 3.
- Figure 5(a) and Figure 5(b) are isometric views of a lens of the present invention in its accommodated state and unaccommodated state respectively.
- Figures 5(c) and 5(d) are schematic views showing placement of the lens in the eye.
- Figure 6 is an isometric view of an embodiment of the present invention similar to Figure 4 except that there are fenestration holes in the haptic body.
- Figure 7 is an isometric view of an embodiment of the present invention similar to Figure 6 except the optical body in Figure 7 is a negative lens while Figure 6 has a positive optical body.
- Figures 8 and 9 are isometric views of embodiments of the present invention including a groove in the transition zone.
- Figure 10 is a perspective view of an embodiment of the present invention showing the groove in the haptic area.
- Figure 11 is a perspective view of an embodiment of the present invention showing that part of the dioptic power may be provided by the second component of the lens.
- Figures 12 and 13 are isometric views of two additional embodiments of the present invention.
- Figure 14 shows the mold used for making the lenses of the present invention.
- the present invention provides an accommodating lens for patients whose natural lens has been removed. It also provides an accommodating lens which can avoid secondary cataract formation. These and other additional objects are achieved by providing an accommodating lens which has two main components. The first component is for providing the optical function as the lens and the second component is for preventing PCO. Additional optional lens structure features include a guiding function which directs the optical body of the lens in its bi-directional movement, i.e., towards the anterior or posterior chambers along the eye's optical axis, corresponding to the contraction or relaxation of the ciliary muscle via the zonules.
- One embodiment in accordance with the present invention is an accommodating lens design as illustrated in Figure 3 and its isometric view in Figure 4.
- the lens has two components 1 and 2 as well as a transition zone (3).
- Component 1 is the anterior portion of the lens containing an optical body (4) with an optical diameter in the range of from about 4 to about 7 mm and a haptic body(5).
- the haptic bodies (5) extend outward from opposite edges of the optical body (4).
- the optical body can be designed to be a positive or negative lens with any optical configurations, such as biconvex, biconcave, plano-convex, or plano-concave.
- Component 1 also has a first radius of curvature (Rl in Fig.
- the lens' overall central thickness (T in Fig. 3) is in the range of about 2 to about 5 mm, preferably from about 3 to about 4 mm.
- the overall length (L in Fig. 3) of the lens is in the range of from about 8 to about 13 mm, preferably from about 8 to about 11 mm.
- Component 2 is the posterior portion of the lens with the second radius of curvature (R2 in Figure 3) which approximately matches with that of the human capsule, such as from about 5 to about 9 mm, preferably from about 6 to about 7.5 mm. In this way, component 2 maintains a tight contact with the posterior bag tissue.
- the main purpose for component 2 is to provide a means to prevent epithelial cells from growing into the central lens area so that the PCO can be avoided. Since this second component is located posterior to the optical body, it must allow light to pass through it (for example, by being optically transparent or by having a cut-out section along the line of the optical axis of the first component).
- the transition zone (3) connects component 1 with component 2 and blends the two radii of curvature in a smooth way.
- the transition zone begins at the end of the haptics and continues until the beginning of the radius of curvature of component 2 is reached.
- the main function of the transition zone is to assist the accommodative lens to change focus by axial shift (forward and back) of the optic body.
- an accommodative IOL can be made from elastomeric polymers having appropriate shape memory properties.
- elastomeric polymers include, but are not limited to, silicones, acrylic polymers, and hydrogels.
- the materials used to make the lenses of the present invention are optically clear and of sufficient purity and biocompatibility to permit placement in the eye.
- the IOL comprises component 1 (optical body + haptics), component 2 (the posterior portion of the lens), and a transition zone.
- Component 1 is the optical body with a first radius of curvature and component 2 has a second radius of curvature, connected by a transitional area which blends components 1 and 2 in a smooth way.
- the IOL is made in its accommodated state, with the first radius (Rl) being larger than the second radius (R2).
- the accommodating lens maintains its initial shape, i.e., when the ciliary muscle relaxes.
- ciliary muscle contracts, it tightens up the zonules. This stretches the accommodative IOL so that component 1, i.e., the optical lens, will move along the optical axis toward the posterior chamber.
- the optical power of the lens is reduced due to the shift of the lens along the optical axis, thereby providing far distance vision (see Figures 5(b) and 5(d)).
- the accommodative IOL returns to its initial accommodative lens state due to its material shape memory or elasticity (see Figures 5(a) and 5(c)). Note that in Figures 5(c) and 5(d), when the lens is implanted in the eye, component 2 is in contact with the posterior surface of the capsular bag. This contact prevents or minimizes secondary cataract formation, and helps transmit ciliary muscle force to the lens.
- Additional design features include the selection of different thicknesses for the first component and second component.
- the second component has a larger thickness than the haptics of the first component, the second component has a stronger mechanical strength than the first component.
- the second component works as an arch to support the first component.
- the first component will shift its position toward the posterior chamber, equivalent to a change from an accommodated state to an unaccommodated state (See Figure 5).
- a 1 mm axial shift is equivalent to a change of about 1 - 2 diopters in optical power.
- a portion of the diopter power can be provided by the second component.
- An example of this design is illustrated in Figure 11. In any event, after implantation, component 2 must remain in a substantially close contact with the posterior surface of the capsular bag.
- the present invention may include guiding structures to help the lens shift in response to ciliary muscle movement.
- These guiding structures may, for example, be a groove in the transition zone, such as illustrated in Figures 8, 9, or in the haptic body of component 1, as shown in Figure 10.
- the zonules are tightened up. This flattens the IOL (particularly at the location of the guiding groove) and the optical body shifts toward the posterior chamber. This posterior shift is equivalent to the decrease of the optical power of the IOL.
- zonules are relaxed and the capsule recovers back to its un-stretched shape.
- This relaxation of zonules allows the first component of the accommodating lens to shift forward, i.e., move toward the anterior chamber, resuming its initial lens shape and optic power. This shape recovery is further assisted by a forward pushing force caused by a pressure increase due to the vitreous outflow from the posterior chamber to the interior chamber. This vault toward the anterior chamber is equivalent to an increase in the IOL's optical power, thereby, providing an improvement in near distance vision.
- the present invention provides a novel lens design which includes a second component having a radius of curvature similar to that of a human natural lens in the range of from about 5 to about 9 mm, preferably from about 6 to about 7.5 mm. This way, the second component usually maintains a close contact with the posterior surface of the capsular bag, preventing endothelial cells from growing into the space in between the implant and the capsular bag.
- Intraocular lenses with designs similar to that shown in Figure 2 have been successfully made as follows: In a three-piece (bottom piece, top piece, and the insert piece, see Figure 14) stainless steel mold, was added an appropriate amount of medical grade silicone (NuSil Silicone Technology, MED 6820) onto the bottom piece. The insert piece was carefully placed on the center of the bottom piece followed by the top piece with appropriate lining. The closed mold was tightly clamped and placed in a pre-heated oven at a temperature in the range of 110-140°C for about 30 to 60 minutes. When the mold cooled down to the room temperature, the top piece was removed.
- medical grade silicone NuSil Silicone Technology, MED 6820
- aqueous lubricant such as Healon (manufactured by Pharmacia) was used to wet the space between the insert piece and the intraocular lens. After the majority of the space was lubricated, the insert piece of the mold was pushed out while the lens remained on the bottom piece. The lens was carefully removed from the bottom piece.
Abstract
Description
Claims
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
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AU2002355113A AU2002355113A1 (en) | 2001-07-17 | 2002-07-17 | Accommodative intraocular lens |
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
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US30603101P | 2001-07-17 | 2001-07-17 | |
US60/306,031 | 2001-07-17 | ||
US10/188,677 US6884263B2 (en) | 2001-07-17 | 2002-07-02 | Accommodative intraocular lens |
US10/188,677 | 2002-07-02 |
Publications (2)
Publication Number | Publication Date |
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WO2003009051A2 true WO2003009051A2 (en) | 2003-01-30 |
WO2003009051A3 WO2003009051A3 (en) | 2004-03-04 |
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Application Number | Title | Priority Date | Filing Date |
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PCT/US2002/022785 WO2003009051A2 (en) | 2001-07-17 | 2002-07-17 | Accommodative intraocular lens |
Country Status (3)
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US (1) | US6884263B2 (en) |
AU (1) | AU2002355113A1 (en) |
WO (1) | WO2003009051A2 (en) |
Cited By (19)
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WO2004106045A1 (en) * | 2003-05-27 | 2004-12-09 | Faezeh Mona Sarfarazi | Mold for intraocular lens |
WO2008079671A1 (en) * | 2006-12-22 | 2008-07-03 | Bausch & Lomb Incorporated | Multi-element accommodative intraocular lens |
US7780729B2 (en) | 2004-04-16 | 2010-08-24 | Visiogen, Inc. | Intraocular lens |
US8182531B2 (en) | 2006-12-22 | 2012-05-22 | Amo Groningen B.V. | Accommodating intraocular lenses and associated systems, frames, and methods |
US8486140B2 (en) | 2001-01-30 | 2013-07-16 | Timothy R. Willis | Refractive intraocular implant lens and method |
US8579970B1 (en) | 2005-06-27 | 2013-11-12 | Visiogen, Inc. | Magnifying intraocular lens |
US9011532B2 (en) | 2009-06-26 | 2015-04-21 | Abbott Medical Optics Inc. | Accommodating intraocular lenses |
US9039760B2 (en) | 2006-12-29 | 2015-05-26 | Abbott Medical Optics Inc. | Pre-stressed haptic for accommodating intraocular lens |
EP2805694A4 (en) * | 2012-01-19 | 2015-09-30 | Eyebright Medical Technology Beijing Co Ltd | Posterior chamber-type intraocular lens |
US9198752B2 (en) | 2003-12-15 | 2015-12-01 | Abbott Medical Optics Inc. | Intraocular lens implant having posterior bendable optic |
US9271830B2 (en) | 2002-12-05 | 2016-03-01 | Abbott Medical Optics Inc. | Accommodating intraocular lens and method of manufacture thereof |
US9504560B2 (en) | 2002-01-14 | 2016-11-29 | Abbott Medical Optics Inc. | Accommodating intraocular lens with outer support structure |
US9603703B2 (en) | 2009-08-03 | 2017-03-28 | Abbott Medical Optics Inc. | Intraocular lens and methods for providing accommodative vision |
US9636213B2 (en) | 2005-09-30 | 2017-05-02 | Abbott Medical Optics Inc. | Deformable intraocular lenses and lens systems |
US9814570B2 (en) | 1999-04-30 | 2017-11-14 | Abbott Medical Optics Inc. | Ophthalmic lens combinations |
US9968441B2 (en) | 2008-03-28 | 2018-05-15 | Johnson & Johnson Surgical Vision, Inc. | Intraocular lens having a haptic that includes a cap |
US9987125B2 (en) | 2012-05-02 | 2018-06-05 | Johnson & Johnson Surgical Vision, Inc. | Intraocular lens with shape changing capability to provide enhanced accomodation and visual acuity |
US10695166B2 (en) | 2015-08-14 | 2020-06-30 | Timothy R. Willis | Intraocular lenses (IOLs) and related assemblies and intraocular attachment methods |
US11707354B2 (en) | 2017-09-11 | 2023-07-25 | Amo Groningen B.V. | Methods and apparatuses to increase intraocular lenses positional stability |
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US20040015236A1 (en) * | 1991-11-18 | 2004-01-22 | Sarfarazi Faezeh M. | Sarfarazi elliptical accommodative intraocular lens for small incision surgery |
US8556967B2 (en) | 1999-04-09 | 2013-10-15 | Faezeh Mona Sarfarazi | Interior bag for a capsular bag and injector |
US7662179B2 (en) | 1999-04-09 | 2010-02-16 | Sarfarazi Faezeh M | Haptics for accommodative intraocular lens system |
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US20060184244A1 (en) * | 2005-02-14 | 2006-08-17 | Nguyen Tuan A | Biasing system for intraocular lens |
US6818158B2 (en) | 2001-01-25 | 2004-11-16 | Visiogen, Inc. | Accommodating intraocular lens system and method of making same |
US20030078658A1 (en) * | 2001-01-25 | 2003-04-24 | Gholam-Reza Zadno-Azizi | Single-piece accomodating intraocular lens system |
US6884261B2 (en) * | 2001-01-25 | 2005-04-26 | Visiogen, Inc. | Method of preparing an intraocular lens for implantation |
US6786934B2 (en) | 2001-01-25 | 2004-09-07 | Visiogen, Inc. | Biasing element for intraocular lens system |
US20030060878A1 (en) | 2001-08-31 | 2003-03-27 | Shadduck John H. | Intraocular lens system and method for power adjustment |
US20070100445A1 (en) * | 2003-02-03 | 2007-05-03 | Shadduck John H | Intraocular lenses and business methods |
US20050021139A1 (en) * | 2003-02-03 | 2005-01-27 | Shadduck John H. | Ophthalmic devices, methods of use and methods of fabrication |
US7261737B2 (en) * | 2002-12-12 | 2007-08-28 | Powervision, Inc. | Accommodating intraocular lens system and method |
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Also Published As
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US20030018384A1 (en) | 2003-01-23 |
AU2002355113A1 (en) | 2003-03-03 |
US6884263B2 (en) | 2005-04-26 |
WO2003009051A3 (en) | 2004-03-04 |
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