WO2002034310B1 - Self-forming orthopedic implants - Google Patents

Self-forming orthopedic implants

Info

Publication number
WO2002034310B1
WO2002034310B1 PCT/US2001/045406 US0145406W WO0234310B1 WO 2002034310 B1 WO2002034310 B1 WO 2002034310B1 US 0145406 W US0145406 W US 0145406W WO 0234310 B1 WO0234310 B1 WO 0234310B1
Authority
WO
WIPO (PCT)
Prior art keywords
implant
configuration
bone
tissue
poly
Prior art date
Application number
PCT/US2001/045406
Other languages
French (fr)
Other versions
WO2002034310A2 (en
WO2002034310A3 (en
Inventor
Andrew M Dickson
Bradley T Estes
Original Assignee
Sdgi Holdings Inc
Andrew M Dickson
Bradley T Estes
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sdgi Holdings Inc, Andrew M Dickson, Bradley T Estes filed Critical Sdgi Holdings Inc
Priority to CA002426784A priority Critical patent/CA2426784A1/en
Priority to AU2002220055A priority patent/AU2002220055A1/en
Priority to EP01988600A priority patent/EP1337287A2/en
Priority to JP2002537361A priority patent/JP2004512099A/en
Publication of WO2002034310A2 publication Critical patent/WO2002034310A2/en
Publication of WO2002034310A3 publication Critical patent/WO2002034310A3/en
Publication of WO2002034310B1 publication Critical patent/WO2002034310B1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/04—Macromolecular materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2400/00—Materials characterised by their function or physical properties
    • A61L2400/16—Materials with shape-memory or superelastic properties
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/02—Materials or treatment for tissue regeneration for reconstruction of bones; weight-bearing implants

Abstract

This invention relates to a self-forming orthopedic implant (10, 40, 60A/B, 100, 140, 200, 250, 280 and 330). The implant is formed a shape memory polymer. The implant can be provided in an original configuration selected to facilitate orthopedic treatment of bone defects, fixation of bone fragments and fractures, or selected to induce bone structures to conform to a desired anatomical configuration. Non-limiting examples of preferred configurations include bone spacers or bone plates, connective tissue replacements (i.e., tendons, ligaments, and/or cartilage). In preferred forms, the implant is deformed to an alternative configuration prior to implantation. Upon application of selected stimuli, for example, heating the implant to a temperature where the shape memory polymeric material becomes elastic induces the implant to revert to its original configuration. In use, when the implant is subjected to the selected stimuli, it conforms to a selected bone tissue or alternatively conforms to a configuration that urgers bone structures into a desired alignment and/or configuration. When used to replace connective tissues, the implant exhibits a tensile strengh to allow the adjacent bone structure to articulate, yet provides sufficient force to urge the bone structures into a desired position and alignment.

Claims

38AMENDED CLAIMS[received by the International Bureau on 27 September 2002 (27 09 02), original claims 1 -88 replaced by new claims 1 -80 (9 pages)]
1. An orthopedic implant for a bone structure, said implant comprising a deformable body defining a spinal spacer for implantation between adjacent vertebrae and formed of a shape memory polymeric material, said body provided in a first configuration and capable of deforming to a second configuration upon application of selected stimuli, wherein said second conformation at least a portion of said body matingly conforms to a portion of the bone structure.
2. The implant of claim 1 wherein the body in the first configuration has a first external volume and in the second configuration has a second external volume greater than the first external volume.
3. The implant of claim 1 wherein the body in the first configuration has a first external volume and the body in the second configuration has a second external volume less than the first external volume.
4. The implant of claim 1 wherein the body includes an internal cavity for receipt of an osteogenic material.
5. The implant of claim 1 wherein the body defines a flexible connecting member between two or more adjacent bone portions.
6. The implant of claim 1 wherein said body is provided in an original configuration.
7. The implant of claim 6 wherein said second confirmation is substantially equivalent to said original configuration.
8. The implant of claim 1 wherein the body deforms to said second configuration upon implantation. 39
9. The implant of claim 1 wherein said body in said second configuration promotes fixation of two or more bone portions.
10. The implant of claim 1 wherein said body contacts two or more adjacent bone portions and in said second configuration permits articulation between the two or more adjacent bone portions.
11. The implant of claim 1 wherein said body in said first configuration is secured to one or more bone portions prior to deforming to the second configuration.
12. The implant of claim 1 wherein the bone structure includes a cavity and said second configuration matingly conforms to the cavity in the bone structure.
13. The implant of claim 1 wherein the shape memory polymeric material is elastic at a deformation temperature and said selected stimuli includes heating the body to a temperature equal or greater than the deformation temperature.
14. The implant of claim 13 wherein the deformation temperature is between about 38° C and about 65° C.
15. The implant of claim 15 wherein the deformation temperature is between about ambient temperature and 65° C.
16. The implant of claim 1 wherein the shaped memory polymeric material is biodegradable.
17. The implant of claim 1 wherein the shaped memory polymeric material is non- biodegradable.
18. The implant of claim 1 wherein the shaped memory polymeric material is selected from the group consisting of: polylactide, polyglycolide, poly(lactide-co-glycolide), polyurethane, poly(ethylene-co-vinyl acetate), poly(ethylene-co-propylene), poly(ethylene- 40
co-propylene-co-diene), poly(ε-caprolactone), poly(β-hydroxybutyrate), poly(β- hydroxybutyrate-co-hydroxyvalerate), poly(methacrylate), poly(methyl methylacrylate), poly(acrylate), and mixtures, copolymers and blends thereof.
19. An orthopedic implant for two or more adjacent bone portions said implant comprising a body formed of a material comprising a biodegradable shape memory polymer, said body provided in a first configuration and adapted to bear against at least one of said adjacent bone portions, wherein said body deforms upon application of selected stimuli to a second configuration to apply a force to said adjacent bone portions.
20. The implant of claim 19 wherein said force is a compressive force on the adjacent bone portions.
21. The implant of claim 19 wherein said body exhibits a desired tensile strength to replace a tendon or ligament for said two or more adjacent bone portions.
22. The implant of claim 19 wherein the implant includes a bone plate.
23. The implant of claim 19 wherein the body defines a bone spacer.
24. The implant of claim 19 wherein the body defines a flexible connective member between the adjacent bone portions.
25. The implant of claim 19 wherein the body comprises a cavity for receipt of an osteogenic material.
26. The implant of claim 19 wherein said body in said second configuration promotes fixation of the adjacent bone portions.
27. The implant of claim 19 wherein said body permits articulation between adjacent bone portions.
28. The implant of claim 19 wherein the shape memory polymer is elastic at a deformation temperature and said selected stimuli includes heating the body to a temperature equal to or greater than the deformation temperature.
29. The implant of claim 19 wherein the deformation temperature is between about 38° C and about 65° C.
30. The implant of claim 19 wherein the deformation temperature is between about ambient temperature and 65° C.
31. The implant of claim 19 wherein the shaped memory polymeric material is selected from the group consisting of: polyurethane, poly(ethylene-co-vinyl acetate), poly(ethylene-co-propylene), poly(ethylene-co-propylene-co-diene), poly(methacrylate), poly(methyl methylacrylate), poly(acrylate), and mixtures, copolymers and blends thereof.
32. An orthopedic implant comprising a non-biodegradable body formed of a shape memory polymeric material and comprising at least one surface adapted to bear against bone tissue wherein said body is provided in a first configuration and upon heating to a deformation temperature said body deforms to a second configuration.
33. The implant of claim 32 wherein the body in the first configuration has a first external volume and in the second configuration has a second external volume greater than the first external volume.
34. The implant of claim 32 wherein the body in the first configuration has a first external volume and the body in the second configuration has a second external volume less than the first external volume.
35. The implant of claim 32 wherein the body defines bone plate.
36. The implant of claim 32 wherein the body defines bone spacer. 42
37. The implant of claim 32 wherein the body defines a flexible connective member.
38. The implant of claim 32 wherein said body is provided in an original configuration.
39. The implant of claim 32 wherein the body self deforms to said second configuration upon implantation.
40. The implant of claim 32 wherein the deformation temperature is between about 38° C and about 65° C.
41. The implant of claim 32 wherein the deformation temperature is between about ambient temperature and 65° C.
42. The implant of claim 32 wherein said body in said second configuration permits articulation between adjacent bone portions.
43. The implant of claim 32 wherein said second configuration matingly conforms to a cavity in the bone tissue.
44. An orthopedic implant for bone tissue said implant comprising body formed of a material comprising a shape memory polymer provided to elastically deform at a deformation temperature, said body provided in a first configuration selected to facilitate implantation and deformable to a second configuration upon heating to a temperature equal to or greater than the deformation temperature, said second configuration provided to facilitate orthopedic treatment.
45. The implant of claim 44 wherein the body in the first configuration has a first external volume and in the second configuration has a second external volume greater than the first external volume. 43
46. The implant of claim 44 wherein the body in the first configuration has a first external volume and the body in the second configuration has a second external volume less than the first external volume.
47. The implant of claim 44 wherein the body defines a bone spacer.
48. The implant of claim 44 wherein the body defines bone plate.
49. The implant of claim 44 wherein the body defines a flexible connective member.
50. The implant of claim 49 wherein the body connects the bone tissue to a second tissue selected from the group consisting of: bone tissue, ligament tissue, tendon tissue and cartilage tissue.
51. The implant of claim 49 wherein the body is adapted to replace a portion of ligament tissue, tendon tissue or cartilage tissue.
52. The implant of claim 49 wherein the body includes tissue promoting growth factors.
53. The implant of claim 44 wherein the body self deforms to said second configuration upon implantation.
54. The implant of claim 44 wherein said body is provided in an original configuration.
55. The implant of claim 44 wherein the deformation temperature is between about 38° C and about 65° C.
56. The implant of claim 44 wherein the deformation temperature is between about ambient temperature and 65° C. 44
57. The implant of claim 44 wherein the deformation temperature is below normal body temperature.
58. The implant of claim 44 wherein said body in said second configuration permits articulation between adjacent bone portions.
59. The implant of claim 44 wherein said second configuration matingly conforms to a cavity in the bone tissue.
60. A spinal spacer for insertion into a spine, said spacer formed of a material including a shape memory polymer and movable between a first configuration and a second configuration by action of the shape memory polymer.
61. The spacer of claim 60 provided in an original configuration.
62. The spacer of claim 61 wherein the second configuration is substantially equivalent to said original configuration.
63. The spacer of claim 60 wherein said second configuration is larger than said first configuration.
64. The spacer of claim 60 inserted into a disc space.
65. The spacer of claim 60 inserted into a vertebral body.
66. An orthopedic implant comprising a body adapted to contact a vertebral bone and said body formed from a non-biodegradable material comprising a shape memory polymer and movable between a first configuration and a second configuration by action the shape memory polymer.
67. The implant of claim 66 wherein said body defines a spacer. 45
68. The implant of claim 66 wherein said body defines a bone plate.
69. The implant of claim 66 wherein said body defines a flexible connective member between the vertebral bone and a second tissue.
70. The implant of claim 66 wherein the second tissue comprises bone tissue.
71. The implant of claim 66 wherein the second tissue comprises ligament tissue.
72. The implant of claim 66 wherein the second tissue comprises tendon tissue.
73. A method of orthopedic treatment of a bone defect, said method comprising: selecting an orthopedic implant comprising a deformable body provided in a first configuration and formed of a shape memory polymeric material contacting said implant to the bone defect; stimulating said implant to deform said body to a second configuration.
74. The method of claim 73 wherein said shape memory polymeric material is provided to elastically deform at a deformation temperature and wherein said stimulating comprises heating said shape memory polymeric material to a temperature equal to or greater than the deformation temperature.
75. The method of claim 73 wherein the implant contacts a bone defect prior to deformation.
76. The method of claim 73 wherein the implant deforms prior to contacting the bone defect.
77. The method of claim 73 wherein stimulating induces the body to expand.
78. The method of claim 73 whe_rej .^timulating induces the body to contract. 46
79. A method of preparing a self-forming orthopedic implant, said method comprising: fabricating an implant from a shape memory polymeric material, wherein said implant comprises a deformable body provided in an original configuration; deforming said body to a first configuration; and stimulating said body to induce the body to revert to the original configuration or a second configuration.
80. The method of claim 79 wherein the second configuration is substantially equivalent thereto to original configuration.
PCT/US2001/045406 2000-10-25 2001-10-23 Self-forming orthopedic implants WO2002034310A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
CA002426784A CA2426784A1 (en) 2000-10-25 2001-10-23 Self-forming orthopedic implants
AU2002220055A AU2002220055A1 (en) 2000-10-25 2001-10-23 Self-forming orthopedic implants
EP01988600A EP1337287A2 (en) 2000-10-25 2001-10-23 Self-forming orthopedic implants
JP2002537361A JP2004512099A (en) 2000-10-25 2001-10-23 Self-conforming orthopedic implant

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US69638900A 2000-10-25 2000-10-25
US09/696,389 2000-10-25

Publications (3)

Publication Number Publication Date
WO2002034310A2 WO2002034310A2 (en) 2002-05-02
WO2002034310A3 WO2002034310A3 (en) 2002-10-17
WO2002034310B1 true WO2002034310B1 (en) 2003-02-20

Family

ID=24796852

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/045406 WO2002034310A2 (en) 2000-10-25 2001-10-23 Self-forming orthopedic implants

Country Status (5)

Country Link
EP (1) EP1337287A2 (en)
JP (1) JP2004512099A (en)
AU (1) AU2002220055A1 (en)
CA (1) CA2426784A1 (en)
WO (1) WO2002034310A2 (en)

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USRE43282E1 (en) 1998-09-14 2012-03-27 The Board Of Trustees Of The Leland Stanford Junior University Assessing the condition of a joint and devising treatment
US8690945B2 (en) 2001-05-25 2014-04-08 Conformis, Inc. Patient selectable knee arthroplasty devices
US8862202B2 (en) 1998-09-14 2014-10-14 The Board Of Trustees Of The Leland Stanford Junior University Assessing the condition of a joint and preventing damage
US8882847B2 (en) 2001-05-25 2014-11-11 Conformis, Inc. Patient selectable knee joint arthroplasty devices
US8906107B2 (en) 2001-05-25 2014-12-09 Conformis, Inc. Patient-adapted and improved orthopedic implants, designs and related tools
US8932363B2 (en) 2002-11-07 2015-01-13 Conformis, Inc. Methods for determining meniscal size and shape and for devising treatment
US8951260B2 (en) 2001-05-25 2015-02-10 Conformis, Inc. Surgical cutting guide
US8951259B2 (en) 2001-05-25 2015-02-10 Conformis, Inc. Patient selectable joint arthroplasty devices and surgical tools
US8998915B2 (en) 2001-05-25 2015-04-07 Conformis, Inc. Joint arthroplasty devices and surgical tools
US9000066B2 (en) 2007-04-19 2015-04-07 Smith & Nephew, Inc. Multi-modal shape memory polymers
US9017334B2 (en) 2009-02-24 2015-04-28 Microport Orthopedics Holdings Inc. Patient specific surgical guide locator and mount
US9020788B2 (en) 1997-01-08 2015-04-28 Conformis, Inc. Patient-adapted and improved articular implants, designs and related guide tools
US9023050B2 (en) 2001-05-25 2015-05-05 Conformis, Inc. Surgical tools for arthroplasty
US9180015B2 (en) 2008-03-05 2015-11-10 Conformis, Inc. Implants for altering wear patterns of articular surfaces
US9192391B2 (en) 2001-03-05 2015-11-24 Puget Bioventures Llc Method for minimally invasive total knee arthroplasty
US9286686B2 (en) 1998-09-14 2016-03-15 The Board Of Trustees Of The Leland Stanford Junior University Assessing the condition of a joint and assessing cartilage loss
US9308053B2 (en) 2006-02-06 2016-04-12 Conformis, Inc. Patient-specific joint arthroplasty devices for ligament repair
US9308091B2 (en) 2001-05-25 2016-04-12 Conformis, Inc. Devices and methods for treatment of facet and other joints
US9326780B2 (en) 2006-02-06 2016-05-03 Conformis, Inc. Patient selectable joint arthroplasty devices and surgical tools incorporating anatomical relief
US9387079B2 (en) 2001-05-25 2016-07-12 Conformis, Inc. Patient-adapted and improved articular implants, designs and related guide tools
US9486226B2 (en) 2012-04-18 2016-11-08 Conformis, Inc. Tibial guides, tools, and techniques for resecting the tibial plateau
US9495483B2 (en) 2001-05-25 2016-11-15 Conformis, Inc. Automated Systems for manufacturing patient-specific orthopedic implants and instrumentation
US9579110B2 (en) 2001-05-25 2017-02-28 Conformis, Inc. Patient selectable joint arthroplasty devices and surgical tools

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JP5416090B2 (en) 2007-04-18 2014-02-12 スミス アンド ネフュー ピーエルシー Expansion molding of shape memory polymer
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Cited By (44)

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US9020788B2 (en) 1997-01-08 2015-04-28 Conformis, Inc. Patient-adapted and improved articular implants, designs and related guide tools
USRE43282E1 (en) 1998-09-14 2012-03-27 The Board Of Trustees Of The Leland Stanford Junior University Assessing the condition of a joint and devising treatment
US8862202B2 (en) 1998-09-14 2014-10-14 The Board Of Trustees Of The Leland Stanford Junior University Assessing the condition of a joint and preventing damage
US9286686B2 (en) 1998-09-14 2016-03-15 The Board Of Trustees Of The Leland Stanford Junior University Assessing the condition of a joint and assessing cartilage loss
US9192391B2 (en) 2001-03-05 2015-11-24 Puget Bioventures Llc Method for minimally invasive total knee arthroplasty
US9107679B2 (en) 2001-05-25 2015-08-18 Conformis, Inc. Patient selectable joint arthroplasty devices and surgical tools
US9125673B2 (en) 2001-05-25 2015-09-08 Conformis, Inc. Joint arthroplasty devices and surgical tools
US8945230B2 (en) 2001-05-25 2015-02-03 Conformis, Inc. Patient selectable knee joint arthroplasty devices
US8951260B2 (en) 2001-05-25 2015-02-10 Conformis, Inc. Surgical cutting guide
US8951259B2 (en) 2001-05-25 2015-02-10 Conformis, Inc. Patient selectable joint arthroplasty devices and surgical tools
US9358018B2 (en) 2001-05-25 2016-06-07 Conformis, Inc. Joint arthroplasty devices and surgical tools
US8974539B2 (en) 2001-05-25 2015-03-10 Conformis, Inc. Patient-adapted and improved articular implants, designs and related guide tools
US8998915B2 (en) 2001-05-25 2015-04-07 Conformis, Inc. Joint arthroplasty devices and surgical tools
US9579110B2 (en) 2001-05-25 2017-02-28 Conformis, Inc. Patient selectable joint arthroplasty devices and surgical tools
US9495483B2 (en) 2001-05-25 2016-11-15 Conformis, Inc. Automated Systems for manufacturing patient-specific orthopedic implants and instrumentation
US8926706B2 (en) 2001-05-25 2015-01-06 Conformis, Inc. Patient-adapted and improved articular implants, designs and related guide tools
US9023050B2 (en) 2001-05-25 2015-05-05 Conformis, Inc. Surgical tools for arthroplasty
US9107680B2 (en) 2001-05-25 2015-08-18 Conformis, Inc. Patient selectable joint arthroplasty devices and surgical tools
US9333085B2 (en) 2001-05-25 2016-05-10 Conformis, Inc. Patient selectable knee arthroplasty devices
US9439767B2 (en) 2001-05-25 2016-09-13 Conformis, Inc. Patient-adapted and improved articular implants, designs and related guide tools
US8690945B2 (en) 2001-05-25 2014-04-08 Conformis, Inc. Patient selectable knee arthroplasty devices
US9125672B2 (en) 2001-05-25 2015-09-08 Conformis, Inc. Joint arthroplasty devices and surgical tools
US9387079B2 (en) 2001-05-25 2016-07-12 Conformis, Inc. Patient-adapted and improved articular implants, designs and related guide tools
US9186161B2 (en) 2001-05-25 2015-11-17 Conformis, Inc. Surgical tools for arthroplasty
US9186254B2 (en) 2001-05-25 2015-11-17 Conformis, Inc. Patient selectable knee arthroplasty devices
US8906107B2 (en) 2001-05-25 2014-12-09 Conformis, Inc. Patient-adapted and improved orthopedic implants, designs and related tools
US9216025B2 (en) 2001-05-25 2015-12-22 Conformis, Inc. Joint arthroplasty devices and surgical tools
US9308091B2 (en) 2001-05-25 2016-04-12 Conformis, Inc. Devices and methods for treatment of facet and other joints
US9295482B2 (en) 2001-05-25 2016-03-29 Conformis, Inc. Patient selectable joint arthroplasty devices and surgical tools
US8882847B2 (en) 2001-05-25 2014-11-11 Conformis, Inc. Patient selectable knee joint arthroplasty devices
US8932363B2 (en) 2002-11-07 2015-01-13 Conformis, Inc. Methods for determining meniscal size and shape and for devising treatment
US8965088B2 (en) 2002-11-07 2015-02-24 Conformis, Inc. Methods for determining meniscal size and shape and for devising treatment
US9220516B2 (en) 2006-02-06 2015-12-29 Conformis, Inc. Patient selectable joint arthroplasty devices and surgical tools
US9308053B2 (en) 2006-02-06 2016-04-12 Conformis, Inc. Patient-specific joint arthroplasty devices for ligament repair
US9220517B2 (en) 2006-02-06 2015-12-29 Conformis, Inc. Patient selectable joint arthroplasty devices and surgical tools
US9326780B2 (en) 2006-02-06 2016-05-03 Conformis, Inc. Patient selectable joint arthroplasty devices and surgical tools incorporating anatomical relief
US9308293B2 (en) 2007-04-19 2016-04-12 Smith & Nephew, Inc. Multi-modal shape memory polymers
US9000066B2 (en) 2007-04-19 2015-04-07 Smith & Nephew, Inc. Multi-modal shape memory polymers
US9180015B2 (en) 2008-03-05 2015-11-10 Conformis, Inc. Implants for altering wear patterns of articular surfaces
US9320620B2 (en) 2009-02-24 2016-04-26 Conformis, Inc. Patient-adapted and improved articular implants, designs and related guide tools
US9113914B2 (en) 2009-02-24 2015-08-25 Microport Orthopedics Holdings Inc. Method for forming a patient specific surgical guide mount
US9017334B2 (en) 2009-02-24 2015-04-28 Microport Orthopedics Holdings Inc. Patient specific surgical guide locator and mount
US9566075B2 (en) 2009-02-24 2017-02-14 Microport Orthopedics Holdings Inc. Patient specific surgical guide locator and mount
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WO2002034310A2 (en) 2002-05-02
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EP1337287A2 (en) 2003-08-27
CA2426784A1 (en) 2002-05-02
WO2002034310A3 (en) 2002-10-17

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