WO2002020565A3 - Collections of repeat proteins comprising repeat modules - Google Patents

Collections of repeat proteins comprising repeat modules Download PDF

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Publication number
WO2002020565A3
WO2002020565A3 PCT/EP2001/010454 EP0110454W WO0220565A3 WO 2002020565 A3 WO2002020565 A3 WO 2002020565A3 EP 0110454 W EP0110454 W EP 0110454W WO 0220565 A3 WO0220565 A3 WO 0220565A3
Authority
WO
WIPO (PCT)
Prior art keywords
repeat
collections
proteins
modules
repeat proteins
Prior art date
Application number
PCT/EP2001/010454
Other languages
French (fr)
Other versions
WO2002020565A2 (en
Inventor
Michael Tobias Stumpp
Patrick Forrer
Hans Kaspar Binz
Andreas Plueckthun
Original Assignee
Univ Zuerich
Michael Tobias Stumpp
Patrick Forrer
Hans Kaspar Binz
Andreas Plueckthun
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to DE60140474T priority Critical patent/DE60140474D1/en
Application filed by Univ Zuerich, Michael Tobias Stumpp, Patrick Forrer, Hans Kaspar Binz, Andreas Plueckthun filed Critical Univ Zuerich
Priority to JP2002525184A priority patent/JP5291279B2/en
Priority to AU2002218166A priority patent/AU2002218166A1/en
Priority to DK01984591.6T priority patent/DK1332209T3/en
Priority to US10/363,552 priority patent/US7417130B2/en
Priority to EP01984591A priority patent/EP1332209B1/en
Priority to CA2421447A priority patent/CA2421447C/en
Priority to AT01984591T priority patent/ATE448301T1/en
Publication of WO2002020565A2 publication Critical patent/WO2002020565A2/en
Publication of WO2002020565A3 publication Critical patent/WO2002020565A3/en
Priority to US12/222,525 priority patent/US8110653B2/en
Priority to US13/330,336 priority patent/US9006389B2/en
Priority to US14/637,112 priority patent/US9657287B2/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1055—Protein x Protein interaction, e.g. two hybrid selection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • C07K14/4703—Inhibitors; Suppressors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1037—Screening libraries presented on the surface of microorganisms, e.g. phage display, E. coli display
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1044—Preparation or screening of libraries displayed on scaffold proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1093—General methods of preparing gene libraries, not provided for in other subgroups

Abstract

The present invention relates to collections of repeat proteins comprising repeat modules which are derived from one or more repeat units of a family of naturally occurring repeat proteins, to collections of nucleic acid molecules encoding said repeat proteins, to methods for the construction and application of such collections and to individual members of such collections.
PCT/EP2001/010454 2000-09-08 2001-09-10 Collections of repeat proteins comprising repeat modules WO2002020565A2 (en)

Priority Applications (11)

Application Number Priority Date Filing Date Title
EP01984591A EP1332209B1 (en) 2000-09-08 2001-09-10 Collections of repeat proteins comprising repeat modules
JP2002525184A JP5291279B2 (en) 2000-09-08 2001-09-10 A collection of repetitive proteins containing repetitive modules
AU2002218166A AU2002218166A1 (en) 2000-09-08 2001-09-10 Collections of repeat proteins comprising repeat modules
DK01984591.6T DK1332209T3 (en) 2000-09-08 2001-09-10 Collections of repeat proteins containing repeat modules
US10/363,552 US7417130B2 (en) 2000-09-08 2001-09-10 Collection of repeat proteins comprising repeat modules
DE60140474T DE60140474D1 (en) 2000-09-08 2001-09-10 COLLECTION OF PROTEINS WITH REPEATED SEQUENCES (REPEAT PROTEINS) CONTAINING REPETITIVE SEQUENCE MODULES
CA2421447A CA2421447C (en) 2000-09-08 2001-09-10 Collections of repeat proteins comprising repeat modules
AT01984591T ATE448301T1 (en) 2000-09-08 2001-09-10 COLLECTION OF PROTEINS WITH REPEATING SEQUENCES (REPEAT PROTEINS) THAT CONTAIN REPETITIVE SEQUENCE MODULES
US12/222,525 US8110653B2 (en) 2000-09-08 2008-08-11 Collections of repeat proteins comprising repeat modules
US13/330,336 US9006389B2 (en) 2000-09-08 2011-12-19 Repeat protein from collection of repeat proteins comprising repeat modules
US14/637,112 US9657287B2 (en) 2000-09-08 2015-03-03 Repeat protein from collection of repeat proteins comprising repeat modules

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP00119670 2000-09-08
EP00119670.8 2000-09-08

Related Child Applications (3)

Application Number Title Priority Date Filing Date
US10363552 A-371-Of-International 2001-09-10
US10/363,552 A-371-Of-International US7417130B2 (en) 2000-09-08 2001-09-10 Collection of repeat proteins comprising repeat modules
US12/222,525 Division US8110653B2 (en) 2000-09-08 2008-08-11 Collections of repeat proteins comprising repeat modules

Publications (2)

Publication Number Publication Date
WO2002020565A2 WO2002020565A2 (en) 2002-03-14
WO2002020565A3 true WO2002020565A3 (en) 2002-11-07

Family

ID=8169793

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2001/010454 WO2002020565A2 (en) 2000-09-08 2001-09-10 Collections of repeat proteins comprising repeat modules

Country Status (10)

Country Link
US (4) US7417130B2 (en)
EP (2) EP1332209B1 (en)
JP (3) JP5291279B2 (en)
AT (1) ATE448301T1 (en)
AU (1) AU2002218166A1 (en)
CA (1) CA2421447C (en)
DE (1) DE60140474D1 (en)
DK (1) DK1332209T3 (en)
ES (1) ES2335861T3 (en)
WO (1) WO2002020565A2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9433684B2 (en) 2008-08-19 2016-09-06 Nektar Therapeutics Conjugates of small-interfering nucleic acids

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