WO2001035880A1 - Multifocal aspheric lens - Google Patents
Multifocal aspheric lens Download PDFInfo
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- WO2001035880A1 WO2001035880A1 PCT/US2000/031554 US0031554W WO0135880A1 WO 2001035880 A1 WO2001035880 A1 WO 2001035880A1 US 0031554 W US0031554 W US 0031554W WO 0135880 A1 WO0135880 A1 WO 0135880A1
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Classifications
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- A—HUMAN NECESSITIES
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- A61F9/00—Methods or devices for treatment of the eyes; Devices for putting-in contact lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
- A61F9/007—Methods or devices for eye surgery
- A61F9/008—Methods or devices for eye surgery using laser
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- A61F9/00—Methods or devices for treatment of the eyes; Devices for putting-in contact lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
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- A61F9/00—Methods or devices for treatment of the eyes; Devices for putting-in contact lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
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- A61F2009/00844—Feedback systems
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- A61F2009/00861—Methods or devices for eye surgery using laser adapted for treatment at a particular location
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- A61F9/00—Methods or devices for treatment of the eyes; Devices for putting-in contact lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
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Definitions
- Simultaneous vision refers to the class of bifocal contact lenses in which optical power for distance vision and near vision are positioned simultaneously within the pupil area of a user's eye.
- the conventional clinical understanding for simultaneous vision is that a bifocal lens projects both distance and near images simultaneously onto the retina. Depending on the viewing distance of the object of regard, one of the images is in focus, and the other image is out of focus. It is believed that the brain is able to disregard the irrelevant out-of-focus image and to process only the relevant in-focus image. Therefore, whether an object is at distance or near locations, the lens is still able to provide levels of vision that may be acceptable to many patients.
- simultaneous vision lens is the concentric zone bifocal lens in which the distance and near powers form two concentric optical zones. These lenses have included center distance or center near configurations. The dimensions of the two zones are chosen such that approximately equal areas of distance and near power are provided within the pupil area of the eye.
- This lens includes the advantage of providing the user with two relatively large optical areas on the lens.
- the relative areas of distance and near power can deviate significantly such that near vision or distance vision may be favored at the expense of the other. Since this dependence on pupil size is not under the conscious control of the user, this distance or near bias may not be appropriate for the vision requirements of a particular user.
- the total bifocal optical zone of such a lens consists of a series of concentric annuli which must be within the pupil area of the eye and which alternately provide the distance and near power. But as the number of annuli increases, the width of each annulus must decrease if the zone (or at least a significant portion of it) is to remain within the pupil area. This can cause the optical quality of the distance and near powers to degrade because of the reduced dimension of each zone. In addition, undesirable edge effects are created by the boundaries between the various zones. This optical degradation can offset the potential advantages of reducing the dependence on pupil size by the incorporation of the multiple zones.
- an aspheric lens is U.S. Patent No. 5,754,270 (Rehse et a/.).
- the '270 patent discloses a lens having a centrally located aspherical first optical zone, a second aspherical concentric optical zone and a transition zone that provides a rapid power shift between the first zone and the second zone.
- This lens suffers from the disadvantage of compromising a user's visual acuity at a particular power value because it includes ranges of powers rather than zones with selected powers.
- Yet another type of simultaneous vision lens is based on diffractive optics. In theory this lens provides nearly equal levels of distance and near vision with minimal dependence on pupil size, but in practice the clinical acceptance of diffractive bifocal contact lenses has been relatively low. It is not clear whether this low acceptance is primarily due to limitations in the inherent quality of diffractive optics or due to the complexity of the diffractive optical element which is quite difficult to manufacture.
- simultaneous vision in terms of a near image and a distance image
- the conventional theory assumes that there are two distinct retinal images which the brain can somehow distinguish and process separately. At any particular moment the eye is looking at a specific object of regard which is at a particular viewing distance. With all simultaneous vision lenses a partially degraded image of that object is projected onto the retina. The consequence of this image degradation is a loss of visual information (less signal, more noise), and the quality of the degraded image may or may not be acceptable to the patient. The clinical effects of this degradation may be measured objectively in terms of reduced visual acuity and contrast sensitivity.
- subjective blur The subjective effects of the degradation are perceived by the patient in various ways which are collectively referred to as subjective blur. Therefore, when wearing a simultaneous vision lens, the patient may not be selecting between separate distance and near images. Rather, in the presence of subjective blur the patient may be attempting to function with the reduced level of visual information that is provided by a degraded image.
- the visual system does have the ability to filter out some of the noise, and many patients demonstrate a tremendous potential to adapt to subjective blur. In some patients the adaptation is so complete that they may not report any subjective blur even though by objective measures their vision may be obviously compromised. However, the opposite situation may occur where an objective assessment indicates normal vision performance, but the patient paradoxically complains of poor vision. Therefore, there is a need for an improved simultaneous lens design that maximizes the available visual information for objects of regard at distance and at near locations and concurrently minimizes visual disturbances. Also, there is a need to apply that improved design to alternatives to contact lenses, such as the latest developing technologies of corneal reshaping that are becoming more common alternatives.
- the present invention provides an optimized lens construction that provides for the reduction of visual disturbances that result from the transitions between areas as formed in past lenses while providing an enhanced visual acuity over a range of distances.
- a lens that combines the positive features of a concentric design with the positive features of an aspheric design in a unique integrated design that minimizes the disadvantages of each.
- the present invention provides a lens having a plurality of vision areas.
- the plurality of areas including a first vision area, a second vision area surrounding the first vision area, and a third vision area surrounding the second vision area.
- the first vision area having a first power
- the second vision area having a range of powers
- the third vision area having a second power distinct from the first power.
- One of the first, second and third vision areas having an aspheric surface designed to provide a monotonic gradient in power and the other areas having either spherical surfaces to provide single power values or aspheric surfaces designed to correct optical aberrations within these single power areas.
- one embodiment of this invention is directed to a method of reprofiling a cornea of an eye to provide the eye with a multi-focal capability to compensate for presbyopia.
- the method includes providing a laser operable to deliver ablative laser radiation to the cornea; and selectively exposing the cornea to said ablative radiation to create a first vision area, a second vision area surrounding the first area, and a third vision area surrounding the second vision area, the first vision area having a first substantially single power, the second vision area having a range of powers, the third vision area having a second substantially single power distinct from the first single power, at least one of the first, second and third vision areas having an aspheric surface, and the other two areas having spherical surfaces.
- the invention is directed to a method for modifying the curvature of the cornea for the correction of presbyopia.
- This method includes performing a lamellar cut on the surface of a cornea extending for an incomplete circle so as to form a superficial layer connecting to the cornea in a superior zone; raising the superficial layer to expose an underlying surface of the cornea; performing an ablation or removal of tissue on the underlying surface to modify a curvature of the cornea to create a first vision area, a second vision area surrounding the first area, and a third vision area surrounding the second vision area, the first vision area having a first substantially single power the second vision area having a range of powers, the third vision area having a second substantially single power distinct from the first single power, at least one of the first, second and third vision areas having an aspheric surface, and the other areas having spherical surfaces; and replacing the superficial layer onto the underlying surface.
- the invention is directed to an optical surface in close proximity to the pupil of an eye for correcting presbyopia.
- the optical surface includes a first vision area, a second vision area surrounding the first area, and a third vision area surrounding the second vision area, the first vision area having a first substantially single power the second vision area having a range of powers, the third vision area having a second substantially single power distinct from the first single power, at least one of the first, second and third vision areas having an aspheric surface, and the other areas having spherical surfaces.
- the points on the optical surface are given by the following equations:
- Zi is the chord diameter of the central first vision area
- Z 2 is the chord diameter (the outer diameter) of the second vision area
- Z 3 is the chord diameter of the third vision area
- Z ⁇ is between 1.2 mm and 2.1 mm
- Z 2 is between 2.0 mm and 4.8 mm
- Z 3 is less than 8 mm
- the invention is directed to a method for reshaping the cornea to obtain the optical surface of the third embodiment.
- the method includes reshaping the anterior or an underlying surface of the cornea by ablation or collagen shrinkage, wherein the ablation is performed by applying an excimer laser, surgical laser, water cutting, fluid cutting, liquid cutting or gas cutting technique.
- the cornea reshaping may also include obtaining this optical surface on an artificially created anterior cornea surface by placing a contact lens having the desired optical characteristics on the cornea, or implanting a lens having the desired characteristics in the cornea.
- the invention is directed to a method of pre- adapting a patient to the final presbyopic correction prior to corneal reshaping.
- the method includes providing the patient with a pair of multifocal contact lenses, each lens comprising a first vision area over the central area of a pupil, a second vision area surrounding the first area, and a third vision area surrounding the second vision area, the first vision area having a first substantially single power for a near vision correction, the second vision area having a range of powers, the third vision area having a second substantially single power distinct from the first single power, the second power being for a distance vision correction, and the first and third vision areas being spherical surfaces and the second area being an aspherical surface.
- the cornea is reshaped to achieve an optical surface providing a power correction profile corresponding to the powers in the contact lenses that provided satisfactory vision correction for the patient.
- the method may preferably refine the desired presbyopic correction by providing the patient replacement multifocal contact lenses with a different first power, a different second power, different dimensions for Zi or Z 2 , or a combination of different first and second powers and zone dimensions independently for the dominant eye and non-dominant eye in a step-wise fashion as needed to achieve a correction for presbyopia that is satisfactory for the patient at near, far and intermediate distances.
- lens is intended to be interpreted broadly to include a wide variety of lenses including contact lenses and intraocular lenses.
- power is intended to be interpreted broadly to include a single power or an average power.
- range of powers is intended to be interpreted broadly to include a series of substantially continuous or non-continuous powers.
- area is intended to be interpreted broadly to include zones or regions.
- vision area is intended to include area that contributes to the vision of a user.
- FIG. 1 is a front view of the optical portion of a contact lens constructed in accordance with one preferred embodiment of the present invention
- FIG. 2 is a graph that illustrates a cross-section of a prior art lens
- FIG. 3 is a graph that illustrates the cross-section of the preferred embodiment illustrated in FIG. 1 ;
- FIG. 8 is a front view of the optical portion of a contact lens constructed in accordance with another preferred embodiment.
- FIG. 9 is a diagram illustrating a kit constructed in accordance with another preferred embodiment.
- FIG. 10 is a front view of a contact lens constructed in accordance with yet another preferred embodiment.
- FIG. 11 is a cross-section of the embodiment of FIG. 10.
- FIG. 1 is a front view of the optical portion of one preferred embodiment of the present invention that is also represented in part by the graph shown in FIG. 3.
- FIG. 1 illustrates a contact lens 10 having a center near configuration.
- the center area 12 is a single power area that provides the desired near power.
- the outer area 16 is a single power area that provides the desired distance power.
- Intermediate area 14 is a gradient power aspheric area which provides a continuous and monotonic power change from the near power of area 12 to the distance power of area 16. While the center area 12 and outer area 16 are single power areas in the preferred embodiment, it should be recognized that each of these areas could also be formed from a plurality of areas having multiple powers.
- the dashed circle within the area 16 represents the dimensions of a typical pupil size.
- the intermediate area 14 acts as an area of extended depth of focus. As such, the intermediate area 14 contributes to vision over a range of object distance including that for distance vision, near vision, and intermediate distance vision.
- center area 12 and intermediate area 14 in combination (approximately 70% of the area of a 3.0 mm pupil or approximately 52% of the area of a 3.5 mm pupil in one of the following examples) contribute to near vision.
- intermediate area 14 and outer area 16 in combination (approximately 61% of the area of a 3.0 mm pupil or approximately 72% of the area of a 3.5 mm pupil in one of the following examples) contribute to distance vision.
- the intermediate area 14 provides a useful level of intermediate distance vision over approximately 32% of the area of a 3.0 mm pupil or approximately 24% of the area of a 3.5 mm pupil.
- each lens may be custom made to meet the specific power prescription and other individual characteristics of the user.
- factors such as pupil size, vocational requirements, and even personal habits and preferences can be considered to produce a custom designed lens; i.e., a lens having optical areas, power values, and dimensions specifically selected to suit the needs of a particular user.
- the dimensions of the three areas may be standardized to a few choices which satisfy most requirements of an average user population but which are also compatible with the economy of scale derived from volume manufacturing.
- a toric surface may also be used with the lens to correct an astigmatism. The toric surface would be used on the side opposite the areas 12, 14, 16.
- the diameter for each area and the percentage of pupil area for typical pupil sizes are listed as follows: Table 1
- the lens can readily be designed to have bifocal Add powers of any desired value. In normal clinical practice, the most commonly prescribed Add powers are in the range of +0.75 D to +2.50 D, but Add powers beyond this range are prescribed occasionally.
- the radii of curvature for the center area 12 and the outer area 16 are then determined from the prescribed distance power and Add power from the standard optical formulas which are used routinely by those skilled in the art.
- the variables which specify the aspheric area of the present invention are then determined using the methods described in detail below. Listed in the tables below are the resulting specifications for a sample range of distance powers in a lens with a +1.50 D Add power with the zone dimensions given above in Tables 1-2.
- r-i, r 2 , and r 3 are variables which describe the radii of curvature of the central, intermediate, and outer areas
- p 2 is a variable which describes the asphericity of the intermediate area
- ⁇ 2 and 8 3 are position variables for the intermediate and outer areas. All these variables are more fully explained below when the formal mathematical descriptions of these respective surfaces are developed. It is assumed in these examples that the multiple optical areas are on the anterior surface of the contact lens, but if desired each example may be computed for its equivalent posterior surface configuration.
- FIG. 2 illustrates the appearance in cross section of a prior art concentric two-area bifocal lens (the curves are exaggerated to make the features of the surface profile visible in the figure).
- the curves are exaggerated to make the features of the surface profile visible in the figure.
- the local tangent to the surface profile approaches different limiting values as the intersection is approached from either side of the corner.
- the sharp corner at A in FIG. 2 may be rounded by a blending curve connecting the two areas (the dashed curve B in FIG. 2).
- a blend curve can eliminate the discontinuity in the local tangent to the surface profile and may, for example, be created by a polishing or buffing operation on the original unblended surface.
- merely rounding a sharp corner does not completely eliminate the corner nor its effects.
- the surface profile in the region of the original concentric areas is concave downward in the figure, but the region of the blend curve B is concave upwards in the figure.
- the slope is sometimes increasing in value and sometimes decreasing in value. This means that the second derivative to the surface profile changes sign at either side of the rounded corner.
- the potential for a disturbing edge effect is still present in such a blended profile.
- the transition of the present invention significantly avoids these disturbing effects.
- Each of the surface areas or zones of the present invention is a surface of revolution.
- the surface of each zone may be specified mathematically in two dimensions in terms of its cross section.
- the full three dimensional surface is then generated by rotating the cross section about an axis of revolution.
- this axis of revolution is also the optical axis of the contact lens, and the geometrical center of the contact lens lies on this axis.
- the contact lens must also incorporate an appropriate system for ballasting the lens such as commonly found in toric contact lenses.
- a prism ballast system may be used to maintain the proper orientation of the contact lens on the eye.
- no such ballasting system is required for the case when the geometrical center of the lens lies on the optical axis.
- the cross sectional surface profile of an aspheric surface of revolution may conveniently be described in terms of a conic section. If the cross section of the surface of revolution is not a true conic section, any small region of the surface profile may still be closely approximated by a portion of a conic section.
- variable p is a quantity that describes the asphericity of the surface and is related to the familiar eccentricity e of the conic section by Eq. (2) or by Eq. (3).
- Eq. (2) applies if the surface curvature becomes flatter as a point on the surface moves away from the apex position, and Eq. (3) applies if the surface curvature becomes steeper as the point moves away from the apex position.
- Eq. (2) may be used to describe both spherical and aspherical surfaces.
- Eq. (1 ) may be elaborated as in Eq. (5) where the index i is used to denote the equation describing the i th surface area.
- i 1 denotes the first surface area
- Eq. (5) describes a surface in which the apex of the surface is located at the origin of the coordinate system. To allow for the fact that the apices of the different surfaces are not all be at the origin, Eq. (5) must be further generalized as in Eq. (6) where ⁇ and m are respectively the x and y coordinates of the apex of the surface.
- the surfaces of the present invention are not limited to those derived from conic sections.
- Eq. (7) may be further generalized to include higher order terms as in Eq. (8). The inclusion of such higher order terms may be desirable in order to minimize or eliminate certain optical aberrations.
- the front surface of the contact lens comprises three zones within the multifocal optical zone.
- each zone has its own characteristics and requirements, the points on the optical surface, which comprises the three zones, may be simply described by the following equations which are derived from Eq. (6) above.
- Z ⁇ is the chord diameter of the central first zone
- Z 2 is the chord diameter (the outer diameter) of the second zone
- Z 3 is the chord diameter of the third zone.
- a starting point for the specification of the preferred embodiment is the selection of the zone dimensions Z ⁇ , Z 2 , and Z 3 .
- the largest zone Z 3 is analogous to the optical zone dimension in a conventional single vision lens. As such it is designed to be significantly larger than the average pupil diameter of the eye. Thus, a typical value for Z 3 is 8.0 mm. There is a great deal of latitude in the dimension, but it is normally not smaller than perhaps 6.0 mm or 6.5 mm. Also, although the theoretical upper limit for Z 3 is the full diameter of the lens, Z 3 is usually smaller than the lens diameter in order to prevent the central or peripheral areas of the lens from becoming either too thick or too thin. Therefore, in the preferred embodiment Z 3 is set at 8.0 mm for many low to mid-range powers, but larger or smaller values of Z 3 are acceptable or desirable for powers in the higher plus or higher minus range.
- the central zone 10 is a single power zone which is designed to provide the power required for near vision.
- the dimension for Z ⁇ is chosen such that the area of the central near zone is substantially equal to 50% of the pupil area of the eye for an average pupil diameter of 3.0 mm to 3.2 mm.
- a central zone in which Z ⁇ is equal to 2.1 mm provides a central area which is approximately 50% of the area of a 3.0 mm pupil.
- the rationale for this choice is that the simultaneous presence of both distance and near power areas within the pupil of the eye represents a degree of compromise to the user and that the best balance between distance and near vision requirements must be to make each power area substantially equal to 50% of the pupil area.
- the present invention is another object of the present invention to provide an optimum configuration of zone areas such that the visual needs of an average user are satisfied over a widest range of common daily activities.
- the size of the central near zone must be large enough to provide for comfortable reading vision.
- near vision may be improved but at the expense of reducing the quality of distance vision and intermediate vision to the extent that these may be unacceptably compromised. Therefore, to achieve a full range of power requirements, it is found that the visual needs of the user are best satisfied when the area of the central near zone is substantially less than 50%.
- the annular second zone 14 is an area of gradient power and provides for intermediate distance vision. Its outer dimension Z 2 must be selected to provide for a useful optical area of gradient power within the pupil while still preserving the vision quality of distance vision provided by the outermost third optical area or zone.
- the variables ⁇ , Pi , ⁇ i, and ⁇ i for the first and third zones are relatively straightforward to specify since these are single power zones which are designed to provide the distance and near optical power requirements. In the preferred embodiment, these single power zones may be spherical or they may be aspherical for the purpose of correcting optical aberration such as the spherical aberration of the contact lens or of the eye.
- the relevant spherical aberration of the single power zones is relatively small.
- the spherical aberration within the corresponding areas of the contact lens is substantially less than about 0.25 D for most powers. Consequently, the aspherical adjustment needed to correct this level of aberration is also small.
- the spherical aberration of the eye varies among individuals but is usually not larger than about 0.50 D for pupils under 3.6 mm. This would require a somewhat larger aspherical adjustment, but it is still relatively small compared to that required for the multifocal power range of the contact lens.
- the spherical radii of curvature r- and r 3 for these zones are determined by the distance and near power prescription of the lens.
- the centers of curvature of these two spherical zones define the optical axis of the lens.
- 3 0.
- the apex positions of the first and third surfaces along the optical axis are specified by ⁇ i and 8 3 respectively.
- ⁇ i 0.
- the apex position of the third surface is then determined only by the value of ⁇ 3 .
- Eq. (14) permits a degree of latitude in the selection of 8 3 such that there is a corresponding latitude in the value of 7 13 .
- the desired characteristics of the power gradient within the second zone 14 provides an additional and important constraint on ⁇ 3 which is not described in multifocal lenses of the prior art.
- Eq. (15) may also be combined with the inverse relationship given in Eq. (7) to obtain Eq. (16). This equation is convenient because it provides an expression for calculating the tangent directly from the chord diameter and does not require explicit knowledge of the sagittal depth.
- Eqs. (25) to (28) represent a system of four non-linear equations in the four unknowns r 2 , p 2 , ⁇ 2 , and ⁇ 2 . Because this system of equations is non-linear, It is convenient to step back and recast Eq. (6) for the second surface into the general quadratic expression in Eq. (29).
- Eq. (30) an alternative but equivalent expression for the second surface is given by Eq. (30), and the corresponding relation for the tangent is given by Eq. (31 ).
- a x 2 + B y 2 + D x + E y 1 Eq. (30)
- Eqs. (32) to (35) are a system of four equations in the four unknowns A, B, D, and E.
- a major advantage of this formulation compared to Eqs. (25) to (28) is that this is now a system of linear equations in the four unknowns and is susceptible to solution by standard methods.
- the solution to this system may be written directly by using the method of Cramer's Rule and the appropriate 4x4 determinants.
- Q denote the determinant defined below in Eq. (36).
- the aspheric second zone provides a useful optical zone in which the gradient power changes monotonically in one direction only.
- a power profile is illustrated in FIG. 4.
- the optical power within the central first zone is essentially constant at the near power value.
- Within the peripheral third zone the power is essentially constant at the distance power value.
- Within the second zone the power changes continuously and monotonically from the near value to the distance value.
- Eq. (45) is the desired constraint on 8 3 .
- Eq. (46) is an identity which may be rearranged to the form given in Eq. (47).
- the terms in Eq. (47) may then be evaluated using Eq. (45) and Eq. (7).
- the contact lens 10 conforms to the following conditions which results in a lens having the advantages of both a spherical and aspherical lens. 1.
- the surface profile of the contact lens 10 is viewed in cross-section (FIG. 3)
- both the intersections of the intermediate area 14 with the center area 12 and with the outer area 16 are smooth, continuous, and without sharp corners.
- the tangent to the curve at that point approaches the exact same value at the actual intersection point.
- the requirement is that the first derivative (dy/dx or y') of the cross-sectional profile is continuous and in particular that the first derivative is continuous at the intersections between the zones.
- the first derivative y' has a single and unique value y at the boundary between center area 12 and the intermediate area 14 and approaches this single value yi' as y approaches Z ⁇ 12 from either side of the boundary between the areas.
- the first derivative y' has a single and unique value ys' at the boundary between the intermediate area 14 and
- the surface profile of the contact lens 10 is either always convex or always concave throughout the optical area. There are no local areas in which the direction of concavity changes sign. Mathematically, this means that there are no points of inflection on the surface profile because the second derivative of the surface profile never changes sign. Equivalently, it means that the first derivative or tangent changes monotonically as an arbitrary point on the surface profile moves across the areas.
- the surface profile is without sharp corners and is even without rounded corners.
- the surface profile is smooth and without "bumps" or "waves” which would imply either sharp or rounded corners.
- the dimensions of the areas must then be computed to maximize the utilization of pupil area for distance, near, and intermediate vision.
- all of the above three conditions must be satisfied in the present invention.
- the failure to meet all of the conditions creates the potential for the visual disturbances which are common and pronounced in prior art lenses. These visual disturbances may be induced by edge effects at the boundaries of the component areas and also by the presence of an inappropriate power profile resulting from an aspheric surface which is not well characterized and controlled.
- the integration in the present invention of single power areas with a monotonic gradient power area achieves a greater utilization of the pupil area at any moment in time whether the object of regard is at distance, at near, or at intermediate viewing. This maximizes the visual information that is available for objects of regard at all viewing distances. Pupil size dependence is reduced because a greater portion of the pupil is utilized at any time. This is achieved without introducing undesirable edge or bifocal jump effects at the area boundaries since, when properly configured, a seamless transition between the single power areas is provided by the intermediate area 14.
- the lens is similar to the preferred embodiment of FIG. 1 except that the diameters of the three areas are configured to provide a greater percentage of pupil area for the near optical power.
- the intermediate area 24 is still computed to satisfy all the conditions listed above for the present invention:
- FIG. 8 Another alternate embodiment of the present invention is shown in FIG. 8.
- the contact lens 30 shown is a distance center embodiment.
- the center area 32 is a single power area that provides the desired distance power.
- the outer area 36 is a single power area that provides the near power.
- the intermediate area 34 is a gradient power aspheric area that provides a continuous power transition from the center area 32 to the outer area 36.
- the diameters of the different power areas are the same as in FIG. 7 but the order of distance and near powers is reversed:
- the power areas of the present invention may be placed on the anterior or the posterior surface of a soft contact lens fabricated from any suitable soft material which is biocompatible with the eye and which can support surfaces of good optical quality.
- soft materials include but are not limited to water containing polymers and co-polymers which are collectively known as hydrogels, silicone elastomers with minimal water, and water containing silicone polymers.
- suitable hydrogel materials are polymers and co-polymers of hydroxyethylmethylmethacrylate, ethoxyethylmethacrylate, diacetone acrylamide, glycerylmethacrylate, methylmethacrylate.
- the present invention may also be placed on the anterior or the posterior surface of a rigid contact lens from materials such as polymethylmethacrylate, the various silicone acrylate polymers, and fluoroacrylate polymers.
- the lens of the present invention may be manufactured by lathing or molding technology. If by lathing, the lathing equipment must be capable of machining general surfaces which comprise spherical and aspherical profiles.
- One class of lathe with this capability is commonly referred to as a two-axis or X-Y lathe because the position of a cutting tool can be numerically controlled in two independent and orthogonal directions. In the coordinate system described previously the two orthogonal directions are along the x-axis (the direction of sagittal distance) and the y-axis (the direction of chord diameter).
- Other lathes control the movement of the cutting tool by scaling the movement of a cam follower.
- the aspheric surface is produced as the cam follower traces out the profile of a cam or template which serves as a master.
- this method first requires a method for generating the cam which will be the master for the desired aspheric surface; hence, these lathes do not have the flexibility of machining a general aspheric surface at will.
- the lathing equipment must also provide levels of precision and • accuracy which are adequate to ensure that the specific continuity and power profile requirements of the present invention are satisfied. It has been shown previously that small departures on the order of half a micron from the optimum surface can produce the undesirable power profiles illustrated in FIGS. 5 and 6. Precision X-Y lathes are available which provide this required level of control. Therefore, X-Y lathes provide the preferred method of lathing because they combine all the advantages of flexibility, precision, and accuracy.
- Another preferred method of manufacturing the present invention is by molding technology. This method first requires the fabrication of a highly accurate master part which must then be faithfully replicated into the final finished product parts.
- the master part is often machined from a suitable durable metal using an extremely accurate X-Y lathe.
- the advantage to this method is that the effort of accurately producing the aspheric surface of the present invention may be concentrated in the fabrication of a very high quality metal master.
- the metal master In the method known as cast molding the metal master is not used to mold the contact lens directly. Rather in a two-step molding process the metal master is used to injection mold many thousands of plastic masters from polypropylene or from some other suitable hard polymer material. The plastic parts are typically used only once to cast mold the final contact lenses before being discarded. The contact lenses are then hydrated in saline solution to their final form.
- the design of the appropriate metal masters for this cast molding process requires the following steps: 1.
- the shrinkage of the injection molded plastic parts must be determined.
- polypropylene is used, wherein the shrinkage is approximately 1-5% depending on the grade of the polypropylene used, the injection molding process conditions, and other factors.
- the expansion due to hydration of the chosen contact lens polymer material must be determined. In the present process the expansion of the polymer material is found to be approximately 3-11% depending on the formulation of the polymer.
- the metal masters are manufactured using a Moore (Bridgeport, CT) aspheric generator lathe to achieve the final desired geometry.
- the metal masters are then used to injection mold the plastic parts from polypropylene for the cast molding of the final contact lenses.
- the contact lens 10 can also be manufactured using a process known as wet cast molding.
- Low molecular weight diluents may be added to cast hydroxyethyl methacrylate (HEMA) mixtures which are displaced during hydration, providing volumetric control during the hydration process.
- HEMA hydroxyethyl methacrylate
- there is zero swelling In many instances, however, a lower amount of diluent is added such that there is some swelling during the hydration process.
- Lenses were made employing a range of diluent concentrations, with successful results in each case.
- low solids formulations appear to have certain advantages, e.g., (1 ) the low solids monomer contains more diluent and compared to the high solids formulation expands less upon polymerization and hydration; (2) the dimensions of the metal masters for the low solids formulations are therefore closer to that of the final contact lens because the expansion factors are less than those of the high solids formulations; (3) the yields of the low solids formulations are higher because there is less variation in the polymer expansion process when the expansion factor is itself low. Accordingly, if low solids formulations could be implemented so as to perform approximately as well as the high solids formulations, they would be preferred.
- a wet cast ultraviolet light absorbing HEMA polymer having a diluent concentration of approximately 33% was chosen as a preferred material, similar to the materials described in United States Patents 4,028,295; 5,637,726; 5,866,635; and 5,729,322, which are hereby incorporated by reference.
- the present invention can also be sold as a kit 40.
- the kit 40 would include a contact lens 42 constructed in accordance with the present invention in a sterile package and a bacteriostatic or a sterile solution.
- the lens 42 could also be secured in a vial or a blister package and include a storage case 44.
- the kit 40 could also include at least one of a cleaning solution 46 and a disinfecting solution 48.
- the cleaning solution 46 could include conventional cleaning solutions.
- the disinfecting solution 48 could include conventional disinfecting agents.
- the kit 40 could also include a conventional wetting solution 50.
- the present invention may also be used with a durable, frequent replacement, or daily disposable contact lens.
- a made-to-order (MTO) contact lens could also be implemented with the present invention.
- This made to order contact lens could include any of the following combination: spherical or toric, colored, printed, UV blocking materials lathed, cast molded, injection molded, or molded on the base curve and lathed on the optical multifocal surface as described in U.S. Patent No. 5,110,278, the disclosure of which is hereby incorporated by reference for the toric case.
- the present invention may also be implemented with a colored multifocal and a colored toric multifocal contact lens as described in U.S. Patent Nos.
- the present invention may include an area adjacent to the iris of a user that includes a band of dark substantially light-absorbing power as disclosed in U.S. Patent No. 5,302,978, the disclosure of which is hereby incorporated by reference.
- colored lens patterns, pad printing process and mixtures of inks and binders may be used with the lens of the present invention as disclosed in Serial No. 09/298,141 filed on April 23, 1999, in the names of M. Quinn and B. Atkins, the disclosure of which is hereby incorporated by reference.
- a pad printing process using a flexible pad depressed against the surface of the lens to deposit a pattern may be used.
- the ink would include a pigment, enhancing paste and activation solution.
- a UV blocking material as disclosed in Serial No. 09/121 ,071 , filed on July 21 , 1998, in the name of Hermann Faubl, the disclosure of which is incorporated by reference, may also be implemented with the present invention.
- the present invention could also use the invention related to toric lens as described in U.S. patent Nos. 5,020,898, 5,062,701 and 4,976,533, the disclosures of which are hereby incorporated by reference.
- a patient is presbyopic, it is desirable to provide the optimum optical correction for the patient's refractive error. Therefore, if there is a significant astigmatic component to the refractive error in a presbyopic patient, it is desirable to use the present invention in a toric contact lens.
- Such a combination would correct the full refractive error of the patent and also compensate for the loss of near focusing power that occurs in presbyopia.
- the toric surface is placed either on the anterior or the posterior surface, from the point of view of economical manufacturing it is convenient (but not required) to place the bifocal element of the present invention on the surface that is not toric; that is, on the surface opposite to the toric surface.
- both the anterior and posterior surfaces are toric, and the bifocal element may be on either surface.
- Any of the methods for stabilizing a toric lens such as prism ballast and thin zones may be used for stabilizing a bifocal toric combination lens.
- the present invention could also include a method of using a contact lens constructed in accordance with the present invention.
- the method would include the step of a user placing the contact lens over a pupil of the user's eye.
- the contact lens would be constructed in accordance with the present invention.
- the present invention also includes a method for prescribing combinations of contact lens configurations each constructed in accordance with the present invention.
- a method of use known as monovision conventional single vision lenses of different powers are prescribed for the two eyes.
- a single vision lens with the distance power prescription is placed on the dominant eye of the user, and a lens with the near power prescription is placed on the non-dominant eye (although in some subjects it can be preferable to reverse this order and to place the lens with the distance power on the non-dominant eye).
- This method can provide reasonable levels of distance and near vision but with only one eye at a time. Indeed, many users find that the overall level of vision is unacceptable with monovision because the method is disruptive to binocular vision and also because it does not provide for vision at intermediate viewing distances.
- Combination prescriptions in the present invention can minimize these disadvantages which limit the success with monovision.
- a lens in the present invention with a relatively small central area of near power is prescribed one eye.
- near vision is de-emphasized in such a configuration on this eye, the central area is still large enough to provide minimal but useful levels of near vision.
- the distance vision in such a configuration is relatively enhanced.
- a lens in the present invention with a relatively large central area of near power is prescribed for the other eye.
- the near vision is relatively enhanced and the distance vision while not emphasized is still useful.
- the lens with the relatively small central area of near power is prescribed for the dominant eye, and the lens with the relatively large central area is prescribed for the non-dominant eye, but the reverse order may be preferred in individual cases.
- This method of combination prescription has the major advantage of providing a much higher level of binocular vision than is possible with the monovision method because useful levels of both distance and near vision are provided simultaneously to the two eyes.
- This method also has the advantage of providing binocular intermediate distance vision to both eyes because of the gradient power intermediate areas present in the lenses of each eye.
- the optical element of the present invention may be incorporated into the cornea itself using the technology of excimer laser refractive surgery.
- PRK photorefractive keratectomy
- the apparatus disclosed includes a laser means and a beam-shaping means disposed between the laser means and the surface of the cornea, which imposes a defined ablation profile upon the cornea.
- the system can also include a feedback control means for measuring the effectiveness of the laser during operation and for controlling the laser.
- the beam-shaping means can include either an aperture e.g., a beam-shaping stop means alone or in combination with a beam-shaping window, or an mask which is photo-decomposable or otherwise graded in its absorptive capacity to present a predefined profile of resistance to the laser radiation.
- a mask used to correct presbyopia is also described by Vinciguerra et al., Journal of Refractive Surgery, Vol. 14, January/February 1998, pp. 31-37, to correct three presbyopic eyes in three patients.
- a mask consisting of a mobile diaphragm formed by two blunt blades was used to ablate a 10 to 17 ⁇ m deep semi-lunar zone-shaped zone immediately below the pupillary center, steepening the corneal curvature in that area.
- An Aesculap-Meditec MEL excimer laser was used (Aesculap Meditec Gmbh, Heroldsberg, Germany).
- the optical zone corrects for near vision centrally, and far vision peripherally.
- a movable image displacement mechanism enables radial displacement, and angular rotation of the profiled beam exiting from the variable aperture.
- the reference discloses wide area treatment with a laser having a narrower beam than the treatment area, and can be used in the treatment of many conditions in conjunction with presbyopia such as hyperopia, hyperopic astigmatism and irregular refractive aberrations.
- LASIK laser- assisted in situ keratomileusis
- the excimer laser may also be used to sculpt the optical surface of the present invention into the corneas of presbyopic patients.
- the optical considerations for such a multifocal corneal reshaping are analogous to those of placing the optical surface of the present invention on the anterior surface of a contact lens.
- the disclosed method involves making a semicircular lamellar cut on the cornea to form a superficial layer which remains connected to the cornea in a superior zone so as to form a flap.
- the superficial layer is raised to expose the underlying surfaces which are subjected to the desired ablation.
- the superficial layer is then replaced over the underlying surface so as to adhere.
- the flap By forming a flap with the connecting hinge region in a superior zone, the flap, which is raised during the operation and then replaced, will be smoothed over the remaining part of the cornea under the effects of the blinking movement of the eyelid and by gravity. This encourages the distension and centering of the superficial layer and enhances the effects of the ablative treatment.
- the method of the invention also provides greater ease and convenience to the surgeon performing the method.
- the apparatus includes a pulsed laser for producing a pulsed output beam of light.
- a scanning mechanism scans the output beam, and the output beam is operatively associated with the scanning mechanism such that the output beam may be scanned over a predetermined surface defined by a mathematically derived ablation layer boundary curve for each ablation layer.
- a controller is operatively associated with the scanning mechanism so as to deliver output beams to the predetermined surface such that center points of output beams may be disposed within the ablation layer boundary curve, on the ablation layer boundary curve, and outside, but within a predetermined distance from a nearest point on the ablation layer boundary curve so as to integrate the edges of the ablation layer boundary curve to more closely correspond to the desired ablated shape.
- Such a device could be programmed to provide the optics of the present invention.
- the multifocal optical surface, or element, of present invention offers certain advantages over the multifocal contact lens. Unlike a contact lens which may not center exactly or which may move slightly with each blink, the sculpted element will always remain in its original centered position. Also, since each cornea must be individually reshaped, the constraints of volume contact lens manufacturing do not apply. Therefore, there is no need for a "one size fits all approach", and each eye may receive the equivalent of a made-to-order multifocal prescription. Finally, the contact lens version of the present invention may be used to screen patients so that only patients who experience benefits from a particular embodiment of the present invention (of which the patient may sample many) subsequently undergo the laser procedure. Experience with the contact lens prior to the laser procedure may also allow the patient's visual system to become more readily accustomed to the sculpted optics.
- PRK and LASIK are the most commonly practiced techniques for corneal sculpting, other techniques are in use, and new techniques may be developed in the future for reshaping corneas or placing other optical surfaces in close proximity to the pupil.
- U.S. Patent No. 5,618,284, to Sand, issued April 8, 1997 describes a method for reshaping the cornea by thermal shrinkage of the collagen in the cornea due to the application coherent infared radiation.
- the radiation is delivered at a wavelength between about 1.80 microns and 2.55 microns for a sufficient time and intensity to cause the collagen to shrink and contract the cornea into a different shape without causing ablation of the corneal tissue.
- the multifocal optics of this invention are applicable to such techniques, as well as the more common laser scultping techniques.
- the typical zone dimensions of the laser sculpted multifocal element will be comparable to those given in Table 2 for a preferred embodiment in a contact lens. However, the specific dimensions for a given eye may differ somewhat from Table 2 because of the freedom to offer made-to-order prescriptions. Also, the outermost diameter of the optical zone is typically not larger than about 6.5 mm in LASIK, whereas this dimension is on the order of 8 mm or 9 mm in a contact lens and can often be even larger.
- the same considerations for the computation of the specific zones that apply for the contact lens surface also apply in laser corneal reshaping.
- Either a center-near or a center-distance configuration may be selected for the corneal reshaping, but the center-near configuration is preferred just as in the case of the contact lens.
- the center-near configuration also has the advantage that the final corneal thickness profile of the reshaped multifocal region will differ by only a few microns from the thickness profile resulting from the corresponding single-vision procedure with the same distance refractive correction.
- the subjective acceptance of the vision provided by the multifocal element may easily be determined in advance by trial fitting the appropriate multifocal contact lenses.
- the accuracy of the laser reshaping is at least as accurate as the contact lens fabrication process, the vision with the laser reshaped corneal multifocal element should be as good or better than that associated with the multifocal contact lens.
- one embodiment of this invention is directed to a method of reprofiling a cornea of an eye to provide the eye with a multi-focal capability to compensate for presbyopia.
- the method includes providing a laser operable to deliver ablative laser radiation to the cornea; and selectively exposing the cornea to said ablative radiation to create a first vision area, a second vision area surrounding the first area, and a third vision area surrounding the second vision area, the first vision area having a first substantially single power, the second vision area having a range of powers, the third vision area having a second substantially single power distinct from the first single power, at least one of the first, second and third vision areas having an aspheric surface, and the other two areas having spherical surfaces.
- the invention is directed to an optical surface in close proximity to the pupil of a eye for correcting presbyopia.
- the optical surface includes a first vision area, a second vision area surrounding the first area, and a third vision area surrounding the second vision area, the first vision area having a first substantially single power the second vision area having a range of powers, the third vision area having a second substantially single power distinct from the first single power, at least one of the first, second and third vision areas having an aspheric surface, and the other areas having spherical surfaces.
- the points on the optical surface are defined by the following equations:
- Zi is the chord diameter of the central first vision area
- Z 2 is the chord diameter (the outer diameter) of the second vision area
- Z 3 is the chord diameter of the third vision area
- Zi is between 1.2 mm and 2.1 mm
- Z 2 is between 2.0 mm and 4.8 mm
- Z 3 is less than 8 mm
- Xi is the sagittal distance at the boundary between the first vision area and the second vision area
- X 3 is the sagittal distance at the boundary between the second vision area and the third vision area
- y and y 3 are the half chord diameters at these same boundaries
- y-i' and ys' are the
- the first vision area has a near vision correction power
- the third vision area has a distance vision correction power.
- the first vision area covers the central area of a pupil.
- the first and third-vision areas are spherical surfaces and the second area is an aspherical surface.
- the second vision zone is an annular ring concentric with the first vision zone, the second vision zone having an inner diameter between 1.2 mm and 2.1 mm, and an outer diameter between 2.0 mm and 4.8 mm. More preferably, the second vision zone has an inner diameter between 1.5 mm and 1.9 mm, and an outer diameter between 2.3 mm and 3.0 mm. It is also preferred that the second vision area is adjacent the first and third vision areas. Within these dimensions it is preferred that the first vision area covers not more than 50% of the pupil area in indoor ambient lighting conditions, more preferably that the first vision area covers not more than 38% of the pupil area in indoor ambient lighting conditions.
- the second vision area has a range of powers that continuously varies substantially monotonically from the first single power adjacent the first vision area to the second single power adjacent the third vision area.
- the surface profile is such that the first vision area surface has a first tangent adjacent the second vision area surface and the second vision area adjacent the first vision area has the same tangent.
- the third vision area surface has a second tangent adjacent the second vision area surface and the second vision area adjacent the third vision area has the same tangent. More preferably, the surfaces of the first, second and third vision areas have one direction of concavity that does not change.
- the invention is directed to a method for reshaping the cornea to obtain the optical surface of the third embodiment.
- the method includes reshaping the anterior or an underlying surface of the cornea by ablation or collagen shrinkage, wherein the ablation is performed by applying an excimer laser, surgical laser, water cutting, fluid cutting, liquid cutting or gas cutting technique.
- the cornea reshaping may also include obtaining this optical surface on an artificially created anterior cornea surface by placing a contact lens having the desired optical characteristics on the cornea.
- the cornea reshaping may include implanting in the cornea a lens having the desired optical characterisitics.
- laser surgery system is in the form of an ophthalmic surgery system for reprofiling a cornea of an eye to provide the eye with a multi-focal capability to compensate for presbyopia.
- the system includes a laser operable to deliver ablative laser radiation to the cornea; and a laser control system for selectively exposing predetermined portions of the cornea to said ablative laser radiation to create a first vision area on the cornea, a second vision area on the cornea surrounding the first area, and a third vision area on the cornea surrounding the second vision area, the first vision area having a first substantially single power, the second vision area having a range of powers, the third vision area having a second substantially single power distinct from the first single power, at least one of the first, second and third vision areas having an aspheric surface, and the other two areas having spherical surfaces.
- the laser system includes a laser assembly for projecting radiation onto a selected region of an exposed surface of the cornea to effect ablation of said selected region to a certain depth; and a laser system controller for controlling the amount of radiation projected on said region, thereby controlling the ablated depth of the cornea to create a first vision area, a second vision area surrounding the first area, and a third vision area surrounding the second vision area, the first vision area having a first substantially single power, the second vision area having a range of powers, the third vision area having a second substantially single power distinct from the first single power, at least one of the first, second and third vision areas having an aspheric surface, and the other two areas having spherical surfaces.
- the laser system is a photorefractive keratectomy system that includes a radiation source for emitting a laser beam of ablative radiation, a beam-shaping means for receiving the beam and for selectively transmitting at least a portion of the beam to the cornea, and a laser control system for applying the beam to the cornea to remove a selected volume of corneal tissue from a region in an optical zone of the cornea with the ablative radiation, thereby forming a reprofiled region which has a first vision area, a second vision area surrounding the first area, and a third vision area surrounding the second vision area, the first vision area having a first substantially single power, the second vision area having a range of powers, the third vision area having a second substantially single power distinct from the first single power, at least one of the first, second and third vision areas having an aspheric surface, and the other two areas having spherical surfaces.
- the invention is directed to a method for refining the desired presbyopic correction and pre-adapting a patient to the final presbyopic correction prior to corneal reshaping.
- the method includes providing the patient with a pair of multifocal contact lenses, each lens comprising a first vision area over the central area of a pupil, a second vision area surrounding the first area, and a third vision area surrounding the second vision area, the first vision area having a first substantially single power for a near vision correction, the second vision area having a range of powers, the third vision area having a second substantially single power distinct from the first single power, the second power being for a distance vision correction, and the first and third vision areas being spherical surfaces and the second area being an aspherical surface.
- the patient is provided replacement multifocal contact lenses with a different first power, a different second power, different dimensions for Zi or Z 2 , or a combination of different first and second powers and zone dimensions independently for the dominant eye and non-dominant eye in a step-wise fashion as needed to achieve a correction for presbyopia that is satisfactory for the patient at near, far and intermediate distances.
- the cornea is reshaped to achieve an optical surface providing a power correction profile corresponding to the powers in the contact lenses that provided satisfactory vision correction for the patient.
- the patient's vision by providing replacement lenses it is suggested to make only minimum departures from a binocular fit which provides acceptable vision for individual patient's requirements.
- To improve distance vision it is suggested to add a minimum minus power monocularly to the dominant eye with hand-held lenses. Then, determine if the binocular distance and near vision are acceptable. If so, this minus power is added to the distance power of the contact lens for the dominant eye.
- the ADD power of the first vision area is decreased monocularly for the dominant eye to obtain a more acceptable vision for the patient.
- the patient may undergo a corrective procdure to reshape the cornea with an optical surface corresponding to the multifocal power profile in the contact lenses found to be most satisfactory to the patient.
- the contact lenses having the optical characteristics in accordance with one of the embodiments of the invention may be used to screen patients for corneal reprofiling.
- another aspect of the invention includes a method for selecting a patient who is a desirable candidate for corneal sculpting to correct presbyopia.
- This method includes providing the patient with a pair of multifocal contact lenses, each lens comprising a first vision area over the central area of a pupil, a second vision area surrounding the first area, and a third vision area surrounding the second vision area, the first vision area having a first substantially single power for a near vision correction, the second vision area having a range of powers, the third vision area having a second substantially single power distinct from the first single power, the second power being for a distance vision correction, and the first and third vision areas being spherical surfaces and the second area being an aspherical surface.
- the patient is provided replacement multifocal contact lenses with a different first power, a different second power, different dimensions for Zi or Z 2 , or a combination of different first and second powers and zone dimensions independently for the dominant eye and non-dominant eye in a step-wise fashion as needed to attempt to achieve a correction for presbyopia that is satisfactory for the patient at near, far and intermediate distances.
- the patient is selected as a candidate if satisfactory vision correction is achieved at near, far and intermediate distances.
- the cornea may be reshaped to achieve an optical surface providing a power correction profile corresponding to the powers in the contact lenses that provided satisfactory vision correction for the patient.
- the vision correction may not be satisfactory to the patient. It should be understood that satisfactory vision correction is a very subjective standard for the individual patient. Thus, as with any change in eye prescription, vision correction may be a compromise between visual acuity and comfort for the patient. Blurring, distortion and ghosting are not infrequent occurrences that may cause a patient to find a multifocal contact lens vision correction not satisfactory though it may objectively provide measurable 20/20 correction. Sometimes, the patient may adapt to the multifocal contact lens over a short nominal period of time, about one week, and these patients are suitable candidates for corneal sculpting of the power correction profile of the contact lens.
Abstract
Description
Claims
Priority Applications (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP00979186A EP1229876A1 (en) | 1999-11-19 | 2000-11-16 | Multifocal aspheric lens |
JP2001537676A JP2003514597A (en) | 1999-11-19 | 2000-11-16 | Multifocal aspheric contact lens |
AU16593/01A AU1659301A (en) | 1999-11-19 | 2000-11-16 | Multifocal aspheric lens |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US44448099A | 1999-11-19 | 1999-11-19 | |
US09/444,480 | 1999-11-19 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2001035880A1 true WO2001035880A1 (en) | 2001-05-25 |
Family
ID=23765083
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2000/031554 WO2001035880A1 (en) | 1999-11-19 | 2000-11-16 | Multifocal aspheric lens |
Country Status (4)
Country | Link |
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EP (1) | EP1229876A1 (en) |
JP (1) | JP2003514597A (en) |
AU (1) | AU1659301A (en) |
WO (1) | WO2001035880A1 (en) |
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EP1396244A3 (en) * | 2002-09-06 | 2004-11-24 | Nidek Co., Ltd. | Corneal-ablation-data calculation apparatus and corneal surgery apparatus |
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JP3860405B2 (en) * | 2000-09-29 | 2006-12-20 | 株式会社ニデック | Cornea surgery device |
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- 2000-11-16 AU AU16593/01A patent/AU1659301A/en not_active Abandoned
- 2000-11-16 JP JP2001537676A patent/JP2003514597A/en active Pending
- 2000-11-16 EP EP00979186A patent/EP1229876A1/en not_active Withdrawn
- 2000-11-16 WO PCT/US2000/031554 patent/WO2001035880A1/en not_active Application Discontinuation
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Also Published As
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EP1229876A1 (en) | 2002-08-14 |
AU1659301A (en) | 2001-05-30 |
JP2003514597A (en) | 2003-04-22 |
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