WO2001010320A1 - Percutaneous catheter and guidewire for filtering during ablation of myocardial or vascular tissue - Google Patents

Percutaneous catheter and guidewire for filtering during ablation of myocardial or vascular tissue Download PDF

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Publication number
WO2001010320A1
WO2001010320A1 PCT/US2000/021242 US0021242W WO0110320A1 WO 2001010320 A1 WO2001010320 A1 WO 2001010320A1 US 0021242 W US0021242 W US 0021242W WO 0110320 A1 WO0110320 A1 WO 0110320A1
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WIPO (PCT)
Prior art keywords
catheter
ablation
filter
distal end
instrument
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Application number
PCT/US2000/021242
Other languages
French (fr)
Inventor
Jonathan D. Root
Kevin Hahnen
Tracy D. Maahs
Original Assignee
Scimed Life Systems, Inc.
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Publication date
Application filed by Scimed Life Systems, Inc. filed Critical Scimed Life Systems, Inc.
Priority to JP2001514849A priority Critical patent/JP2004509650A/en
Priority to CA2378594A priority patent/CA2378594C/en
Priority to DE60020404T priority patent/DE60020404D1/en
Priority to EP00952473A priority patent/EP1294299B1/en
Priority to AT00952473T priority patent/ATE296061T1/en
Publication of WO2001010320A1 publication Critical patent/WO2001010320A1/en

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Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B18/18Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves
    • A61B18/20Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser
    • A61B18/22Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser the beam being directed along or through a flexible conduit, e.g. an optical fibre; Couplings or hand-pieces therefor
    • A61B18/24Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser the beam being directed along or through a flexible conduit, e.g. an optical fibre; Couplings or hand-pieces therefor with a catheter
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B18/04Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating
    • A61B18/12Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating by passing a current through the tissue to be heated, e.g. high-frequency current
    • A61B18/14Probes or electrodes therefor
    • A61B18/1492Probes or electrodes therefor having a flexible, catheter-like structure, e.g. for heart ablation
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B18/02Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by cooling, e.g. cryogenic techniques
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B18/18Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/00234Surgical instruments, devices or methods, e.g. tourniquets for minimally invasive surgery
    • A61B2017/00238Type of minimally invasive operation
    • A61B2017/00243Type of minimally invasive operation cardiac
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B2018/00053Mechanical features of the instrument of device
    • A61B2018/00214Expandable means emitting energy, e.g. by elements carried thereon

Definitions

  • the present invention generally relates to devices and methods useful in capturing embolic material during ablation of myocardial or vascular tissue. More specifically, the devices remove necrotic tissue debris generated during ablation of ectopic foci, e.g., in the left atrium, the right atrium, and the pulmonary vein, in patients with paroxysmal atrial fibrillation or other sustained atrial tachyarrhythmias.
  • the devices include a trapping mechanism for capturing the necrotic tissue debris and may include aspiration capabilities.
  • Atrial fibrillation is perpetuated by reentrant wavelets propagating outside the normal cardiac conduction pathway, resulting in rapid, irregular heart rate and the loss of atrioventricular synchrony. Atrial fibrillation is also important because of the associated fivefold increase in incidence of stroke.
  • Atrial fibrillation Three patterns of atrial fibrillation exist: paroxysmal (intermittent), persistent (but able to be cardioverted), and permanent (cardioversion-resistent), with the pattern progressing over time in a given patient.
  • Two strategies generally exist for managing patients with atrial fibrillation: rate control and anticoagulation versus attempts to restore and maintain sinus rhythm. Generally, in most patients, initial attempts are undertaken to restore sinus rhythm with electrical or pharmacologic cardioversion.
  • Standard anti-arrhythmic agents include amiodarone, procainamide, or quinidine.
  • anti-arrhythmic therapy is that (1) the anti- arrhythmic agents are pro-arrhythmic, e.g., causing torsades de pointe, (2) the anti- arrhythmic agents often carry significant side effects, such as lupus-like syndrome and agranulocytosis, and (3) even with two anti-arrhythmic drugs, some patients may be resistant to pharmacological therapy, e.g., patients may continue to have at least one episode of atrial fibrillation every two days or frequent isolated atrial ectopic beats (more than 700 per day).
  • Atrial fibrillation treatments for atrial fibrillation include catheter ablation of the atrioventricular (AV) node with pacemaker implantation, or modification of the AV node without pacemaker implantation.
  • AV atrioventricular
  • thromboembolic risk is unchanged and atrial systole is not restored with these procedures.
  • Several alternatives have also been available to interrupt the reentrant wavelets, including extensive surgical, or recently, catheter-medicated atriotomy.
  • the success rate of catheter ablation of other sustained atrial arrhythmias e.g., atrial flutter and sustained atrial tachycardia, has been over 90%.
  • Catheter ablation therefore represents an important alternative to pharmacologic therapy for treatment of atrial fibrillation and other sustained atrial arrhythmias.
  • EPS electrophysiologic study
  • three multi-electrode catheters are introduced percutaneously through the femoral veins: one catheter for ablation, one mapping catheter for positioning in the right atrial appendage (for locating ectopic foci in the right atrial and right pulmonary vein) or coronary sinus (for locating ectopic foci in the left pulmonary vein), and another catheter for stimulation of the atrial tissue to induce atrial fibrillation.
  • Atrial foci the left superior, left inferior, right superior, and right inferior pulmonary veins
  • Direct mapping and ablation of the left atrium and pulmonary veins were performed via a trans- septal approach through the foramen ovale which lies in the interatrial septum.
  • the catheters may be inserted retrograde in the aorta through the aortic valve and left ventricle. The ablation was performed at the site with earliest recorded ectopic activity.
  • the ablative techniques used to restore normal sinus rhythm can generate necrotic tissue fragments or blood clots. These tissue debris or thrombi may travel downstream from the procedural site to lodge in other organs, causing stroke, myocardial infarction, renal infarcts, and tissue ischemia in other organs.
  • New devices and methods are thus needed for an ablation catheter having an ability to entrap and/or remove embolic debris generated during ablation of ectopic atrial foci in patients with atrial fibrillation or other sustained atrial arrhythmias, thereby reducing the risk of embolization.
  • the present invention provides devices and methods which include filtering and aspiration capabilities for trapping and removing necrotic tissue debris and thrombi generated during the ablative therapy, thereby minimizing embolization to other organs.
  • the medical device comprises a catheter which includes a flexible elongate member having a distal end adapted to enter a vessel and a proximal end which extends from a patient's vessel and permits control outside the patient's body by a physician.
  • an ablation device At the distal end of the catheter is provided an ablation device and an expandable trapping mechanism.
  • the ablation device may utilize radio frequency, laser, cryogenic, or microwave.
  • the trapping mechanism in certain embodiments, comprises an open-ended tubular member which extends to the proximal region of the catheter and is attached to a vacuum.
  • the trapping mechanism comprises a basket or opening in a tube, which is mounted proximal to the ablation device and surrounds the ablation device.
  • the catheter may include a filtration mesh, typically disposed circumferentially about a distal region of the catheter proximal to the ablation device, so that filtration occurs downstream of the ablation.
  • the filter will typically include a continuous mesh having a proximal edge circumferentially in contact with the outer surface of the catheter and a distal edge attached to an expansion mechanism, which contracts and expands radially outward.
  • expansion means and associated filter mesh on a cannula have been thoroughly discussed in our earlier applications, including Barbut et al., U.S. Application Serial No., U.S. Application Serial No. 08/553,137, filed November 7, 1995, Barbut et al., U.S. Application Serial No. 08/580,223, filed December 28, 1995, Barbut et al., U.S.
  • the catheter in still another embodiment, includes a second lumen communicating with a proximal end and an aspiration port at its distal end.
  • the proximal end of the catheter is adapted for attachment to a vacuum.
  • the port is located distal to the trapping mechanism and proximal to the ablation device for removing tissue debris generated during the ablation.
  • the device comprises a flexible elongate tube having a lumen communicating with a proximal end and a distal end.
  • An expandable entrapping mechanism is mounted on a distal region of the catheter.
  • An ablation catheter which includes an ablation device at its distal end, is disposed within the lumen of the catheter.
  • the catheter may include a second lumen communicating with a distal port adapted for aspiration of tissue debris.
  • the distal end of the catheter is inserted percutaneously through a peripheral vein, e.g., the femoral vein, the brachial vein, the subclavian vein, or the internal/external jugular vein, into the right atrium.
  • a peripheral vein e.g., the femoral vein, the brachial vein, the subclavian vein, or the internal/external jugular vein
  • the ablation device is positioned adjacent to the foci, and the entrapping mechanism, or filter, is expanded.
  • necrotic tissue particles and/or thrombi generated are captured by the filter and/or removed by aspiration.
  • the distal end of the catheter is advanced from the right atrium, through the foramen ovale, and enters the left atrium.
  • the distal end of the catheter may be inserted percutaneously through a peripheral artery, e.g., the femoral artery, the brachial artery, the subclavian artery, or the axillary artery, retrograde into the aorta, the left ventricle, and the left atrium to access the foci in the left atrium or the pulmonary vein.
  • a peripheral artery e.g., the femoral artery, the brachial artery, the subclavian artery, or the axillary artery
  • the distal end of the flexible guiding catheter carrying the filter at its distal region is inserted downstream the site of ablation.
  • the filter is expanded.
  • a steerable ablation catheter, having an ablation device mounted at its distal end, is inserted in the lumen of the guiding catheter to ablate the ectopic foci.
  • the filter is contracted to resume a small shape in close contact with the outer surface of the catheter.
  • the catheter, with captured embolic material, is then withdrawn from the aorta or the vein and removed from the patient's body.
  • the devices and methods disclosed herein are best used in preventing peripheral embolization during ablation of ectopic foci in the right atrium, the left atrium, and the pulmonary veins in patients with atrial fibrillation or other sustained atrial arrhythmias. It will be understood that the devices and methods are applicable to ablating ectopic tissues in other cardiac arrhythmias, such as ventricular tachycardia or Wolff- Parkinson- White syndrome.
  • Fig. 1 depicts a normal cardiac conduction pathway.
  • Fig. 2A depicts an embodiment of an ablation catheter having a trapping mechanism for capturing emboli, comprising a filtration assembly in a contracted state.
  • Fig. 2B depicts the catheter of Fig. 2A having the filtration assembly in an expanded state.
  • Fig. 3 depicts the ablation catheter of Fig. 2B inserted in the right atrium.
  • Fig. 4 depicts another embodiment of the ablation catheter having an aspiration port.
  • Fig. 5 depicts the device of Fig. 4 inserted in the pulmonary vein.
  • Fig. 6A depicts an embodiment of a guiding catheter system for ablation of ectopic foci having a filtration assembly in a contracted state.
  • Fig. 6B depicts the embodiment of Fig. 6 A having the filtration assembly in an expanded state.
  • Fig. 7 depicts another embodiment of the guiding catheter system for ablation of ectopic foci having an inflation seal.
  • Fig. 8 depicts the catheter system of Fig. 7 inserted in the aorta for ablating the ectopic foci in the pulmonary vein.
  • Fig. 9A depicts another embodiment of a trapping mechanism for capturing emboli, having a basket with an adjustable opening at a distal end.
  • Fig. 9B depicts the trapping mechanism of Fig. 9A in a collapsed condition.
  • Fig. 10A depicts another embodiment of the trapping mechanism for capturing embolic material, having clamping fingers and associated mesh.
  • Fig. 10B depicts the trapping mechanism of Fig. 10A in an expanded state.
  • Fig. 1 1 depicts various entry sites for catheter insertion.
  • SA node 1 normal cardiac conduction originates in sinoatrial (SA) node 1 10, located in the upper wall of right atrium 120 as depicted in Fig. 1.
  • the SA node the heart's main pacemaker, generates electrical activity which travels through a conduction pathway. Electrical impulses travel from SA node 1 10 over Bachmann's bundle 1 16 to left atrium 1 17, along anterior internodal tract 1 12, middle intemodal tract 1 13, and posterior internodal tract 114 in right atrium 120 to atrioventricular (AV) node 1 15.
  • AV node the impulse is delayed for approximately 40 milliseconds, allowing atrial contraction, and resumes down through bundle of His 145.
  • the electrical impulse travels rapidly into right bundle branch 125 and left bundle branch 140 and continues down the interventricular septum. From the bundle branches, the impulse continues through Purkinje fibers, which rapidly conduct the impulse to both ventricular endocardium. In this way, the electrical impulse generated from the SA node and terminating in the
  • Purkinje fibers constitutes a cardiac conduction cycle, triggering atrial and ventricular contraction and relaxation, causing the heart to pump blood.
  • right atrium 120 receives deoxygenated blood from superior vena cava (SVC) 101 and inferior vena cava (IVC) 102
  • the blood is passed through tricuspid valves 121 into right ventricle 122.
  • the deoxygenated blood is ejected from the right ventricle into right pulmonary arteries 138 and left pulmonary arteries 139, oxygenated by the lung, and returned to left atrium 117 via right pulmonary veins 137 and left pulmonary veins 136.
  • the oxygenated blood passes through mitral valve 130 into left ventricle 135, which ejects the blood into aorta 100 to perfuse the peripheral organs.
  • the catheter includes a flexible elongate member 10 having a proximal end, distal end 12, ablation instrument 15 mounted at the distal end, and an expansion means, typically filtration assembly 20, mounted on distal region 13 of the catheter.
  • the filtration assembly includes proximal edge 21 circumferentially in contact with an outer surface of the catheter and distal edge 22 which expands radially outward.
  • Filter mesh 25 is associated with the outer surface of the catheter at proximal edge 21 and is operably connected to the filter assembly at distal edge 22. Having the filter assembly in a contracted state as depicted in Fig.
  • FIG. 2 A facilitates insertion of the catheter into a peripheral vessel, such as the femoral vein or artery.
  • filter assembly 20 is expanded as depicted in Fig. 2B to capture embolic debris.
  • Alternative expansion means based on a mechanical expanding mechanism similar to an umbrella frame are described in U.S. application Ser. Nos.
  • the distal end of the catheter can be inserted through a peripheral vein, e.g., the subclavian vein or the internal jugular vein, and through the superior vena cava to insert into the right atrium.
  • a peripheral vein e.g., the subclavian vein or the internal jugular vein
  • distal end 13 of the catheter is inserted through the femoral artery and up through inferior vena cava 102 into right atrium 120 as depicted in Fig. 3.
  • Filtration assembly 20 is contracted at distal region 13 to facilitate catheter insertion.
  • ablation instrument 15 is position adjacent to the affected atrial tissue.
  • Filtration assembly 20 is expanded about distal end 12 of the catheter.
  • the ectopic foci can be ablated using radio frequency, microwave, laser, or cryogenic techniques.
  • Necrotic tissue debris or thrombi generated during the ablation procedure are captured by mesh 25.
  • filtration assembly is contracted, securing the embolic material in the mesh, and removed when the catheter is withdrawn proximally, preventing distal embolization.
  • Another embodiment of the ablation catheter having aspiration port 30 communicating with lumen 31 is depicted in Fig. 4.
  • Lumen 31 at its proximal end is adapted for attachment to a vacuum.
  • the aspiration port is capable of removing myocardial tissue debris or thrombi generated during the ablative procedure under suction.
  • filtration assembly 20 is mounted on distal region 13 of the catheter, proximal to distal end 12 and ablation instrument 15.
  • a peripheral artery such as the femoral artery
  • aorta 100 traverses left ventricle 135, mitral valve 130, and left atrium 117 to insert in left pulmonary vein 136.
  • distal end 12 of the catheter can be inserted through the brachial or the subclavian artery to insert in pulmonary vein 136 via aorta 100 in a retrograde fashion.
  • the catheter can be inserted through a peripheral vein to enter into right atrium 120 via SVC 101 or IVC 102, and insert in pulmonary vein 136 by traversing the foramen ovale, which is patent in some patients, to enter left atrium 1 17.
  • ablation assembly 20 is expanded circumferentially to contact the walls of the pulmonary vein.
  • necrotic tissue debris and thrombi generated can be aspirated by the aspiration port at distal end 12 of the catheter or can be captured by the expanded filtration assembly.
  • the filtration assembly is contracted and removed with the catheter, thereby preventing the emboli from entering left atrium 1 17, through mitral valve 130, left ventricle 135, and exiting aorta 100 downstream to lodge in the peripheral organs.
  • FIG. 6A and 6B An embodiment of a percutaneous guiding catheter system for ablation of ectopic foci is shown in Figs. 6A and 6B.
  • the catheter system includes elongate tubular member 10 having lumen 1 1 communicating with a proximal end and distal port 12.
  • the lumen is adapted for insertion of an ablation catheter having an ablation instrument at its distal end.
  • the lumen may also accommodate other interventional catheters, e.g., an atherectomy catheter.
  • Expandable filtration assembly 20 is mounted on distal region 13 of the catheter.
  • the assembly includes proximal edge 21 circumferentially in contact with an outer surface of the catheter, and distal edge 22 which expands radially outward as depicted in Fig. 6B.
  • the catheter further includes a second lumen 31 communicating with aspiration port 30, and a proximal end which is adapted for attachment to a vacuum.
  • the aspiration port is capable of removing embolic material generated by the ablation instrument under suction.
  • filtration assembly 20 comprises inflation seal 40 disposed about distal region 13 of the catheter, wherein the inflation seal is expandable between a contracted condition and an enlarged condition.
  • Inflation seal 40 comprises a continuous ring of thin tubing attached to filter mesh 25, which is operably connected to the inflation seal at proximal edge 21 and is closely associated with the outer surface of the catheter at distal edge 22.
  • the inflation seal may be constructed from elastomeric or non-elastomeric tubular material which encloses a donut-shaped chamber 41. When deployed, the inflation seal can be expanded by injecting fluid or gas into chamber 41 to fit tightly against the lumen of a vessel. Chamber 41 is in fluid communication with first tubular passage 56 and second tubular passage 57 which permit chamber 41 to be inflated with gas, or preferably a fluid such as saline. Distal region 13 of the catheter may include a plurality of spokes or folding strings 55 made form Dacron ® or other suitable material. Holding strings 55 connect distal region 13 of the catheter to inflation seal 40. The construction and operation of the inflation seal are described in more details in Barbut, et al., U.S. Pat No. 5,662,671, incorporated herein by reference in its entirety.
  • inflation seal 40 and mesh 25 can be inserted through the femoral artery and up through aorta 100 as depicted in Fig. 8.
  • An ablation catheter having ablation instrument 15 at its distal end is disposed in lumen 1 1 of the catheter, and is advanced distally through port 30 to position in pulmonary vein 136 after traversing aortic valve 150 and mitral valve 130.
  • Inflation seal 40 is then expanded by injecting fluid or gas into inflation seal 40 to achieve contact with the inner lumen of aorta 100.
  • Figs. 9A and 9B depict an alternative embodiment of the emboli trapping mechanism having basket 50 with an adjustable opening at distal end 12 of the ablation or guiding catheter.
  • basket 50 is attached at seam 52 to distal end 12 of the catheter.
  • Distal region 53 of basket 50 is attached to a contracting loop or inflation member 55 which is secured to the catheter by support wires 56. In use, contracting loop 55 is narrowed as shown in Fig.
  • Distal end 12 of catheter 10 includes a plurality of clamping fingers 60 which are operable between an open and closed condition.
  • Filtration mesh 25 is disposed over fingers 60 and is positioned to capture embolic material dislodged during the ablative procedure.
  • Ablation catheter 16 having ablation instrument 15 at its distal end is moveably inserted in lumen 11 of catheter 10.
  • ablation catheter 16 may include an aspiration lumen and distal aspiration port.
  • catheter 10 approaches the ectopic focus with open fingers 60 as shown in Fig. 10B.
  • Ablation instrument 15 is positioned adjacent to the ectopic focus having fingers 60 and mesh 25 closed about the ablation catheter. Embolic material generated during the ablative procedure is captured by mesh 25.
  • Fig. 1 A variety of entry sites available for insertion of the ablation catheter from peripheral arteries and veins into the cardiac chambers or the great vessels are shown in Fig. 1 1.
  • the ablation catheter 10 can be inserted through right subclavian vein 342, left subclavian vein 340, right internal jugular vein 332, left internal jugular vein 330, right external jugular vein 336, left external jugular vein 334, right median cubital vein 312, or left median cubital vein 310, and through superior vena cava (SVC) to insert in the right atrium (RA).
  • SVC superior vena cava
  • the catheter can be inserted through right femoral vein 322 or left femoral vein 320 and up through the inferior vena cava (IVC) to insert in the RA.
  • Fig. 11 depicts catheter 10 entering the RA through right femoral vein 322 and right subclavian vein 342.
  • Entrapping mechanism 20 is positioned in the RA.
  • the catheter can be inserted through right brachial artery 212, left brachial artery 210, right axillary artery 226, left axillary artery 225, right subclavian artery 242, or left subclavian artery 240 and through the aorta to enter the LA or the PV.
  • the catheter can be inserted through right femoral artery 222 or the left femoral artery 220, and up through the descending aorta to enter the LA or the PV.
  • Fig. 11 depicts catheter 10 inserted through left femoral artery 220 and left subclavian artery 240.
  • Entrapping mechanism 20 is positioned in the ascending aorta to prevent emboli from traveling downstream in the aorta.
  • ablation of ectopic foci in the LA or the PV can be achieved by a trans-septal approach, having the catheter traversing through the foramen ovale from the RA to the LA. In this approach, the catheter is inserted through the peripheral veins.
  • the length of catheter will generally be between 10 and 200 centimeters, preferably approximately between 30 and 150 centimeters.
  • the inner diameter of the catheter lumen will generally be between 0.2 and 0.8 centimeters, preferably between approximately 0.3 and 0.5 centimeters.
  • the mesh permits flow rates as high as 3L/min or more, more preferably 3.5 L/min or more, more preferably 4 L/min or more, more preferably 4.5 L/min or more, more preferably 5 L/min or more, more preferably 5.5 L/min or more, most preferably at 6 L/min or more at pre-filter maximum aortic systolic pressures (proximal to the mesh) of around 200 mmHg or less.
  • the outer diameter of the expanded inflation seal will generally be at least 1 centimeters, more preferably at least 1.5 centimeters, more preferably at least 2 centimeters, more preferably at least 2.5 centimeters, more preferably at least 3 centimeters, more preferably at least 3.5 centimeters, more preferably at least 4 centimeters, more preferably at least 4.5 centimeters, more preferably at least 5 centimeters, more preferably at least 5.5 centimeters, more preferably at least 6 centimeters, more preferably at least 6.5 centimeters, more preferably at least 7 centimeters, more preferably at least 7.5 centimeters, more preferably at least 8 centimeters, more preferably at least 8.5 centimeters, more preferably at least 9 centimeters, more preferably at least 9.5 centimeters, more preferably at least 10 centimeters, more preferably at least 10.5 centimeters, more preferably at least 11 centimeters, more preferably at least 11.5

Abstract

An ablation catheter system for capturing and removing necrotic tissue and thrombi generated during an ablative procedure is disclosed. The catheter typically includes an elongate member, a filtration assembly disposed within the distal region, and an ablation instrument at the distal end. Alternatively, the ablation instrument is carried on the distal end of an ablation catheter, which is disposed within a lumen of the catheter system. The catheter may further include an aspiration port and lumen. Methods of using the devices in preventing distal embolization during ablative procedure are disclosed.

Description

S P E C I F I C A T I O N
PERCUTANEOUS CATHETER AND GUIDEWIRE FOR FILTERING DURING ABLATION OF MYOCARDIAL OR VASCULAR TISSUE
Field of the Invention
The present invention generally relates to devices and methods useful in capturing embolic material during ablation of myocardial or vascular tissue. More specifically, the devices remove necrotic tissue debris generated during ablation of ectopic foci, e.g., in the left atrium, the right atrium, and the pulmonary vein, in patients with paroxysmal atrial fibrillation or other sustained atrial tachyarrhythmias. The devices include a trapping mechanism for capturing the necrotic tissue debris and may include aspiration capabilities.
Background of the Invention Atrial fibrillation is the most common sustained arrhythmia in the United
States, affecting over 2 million people. Its prevalence increases with age up to 5 percent in people more than 65 years of age. Atrial fibrillation is perpetuated by reentrant wavelets propagating outside the normal cardiac conduction pathway, resulting in rapid, irregular heart rate and the loss of atrioventricular synchrony. Atrial fibrillation is also important because of the associated fivefold increase in incidence of stroke.
Three patterns of atrial fibrillation exist: paroxysmal (intermittent), persistent (but able to be cardioverted), and permanent (cardioversion-resistent), with the pattern progressing over time in a given patient. Two strategies generally exist for managing patients with atrial fibrillation: rate control and anticoagulation versus attempts to restore and maintain sinus rhythm. Generally, in most patients, initial attempts are undertaken to restore sinus rhythm with electrical or pharmacologic cardioversion. Standard anti-arrhythmic agents include amiodarone, procainamide, or quinidine. However, disadvantages associated with anti-arrhythmic therapy are that (1) the anti- arrhythmic agents are pro-arrhythmic, e.g., causing torsades de pointe, (2) the anti- arrhythmic agents often carry significant side effects, such as lupus-like syndrome and agranulocytosis, and (3) even with two anti-arrhythmic drugs, some patients may be resistant to pharmacological therapy, e.g., patients may continue to have at least one episode of atrial fibrillation every two days or frequent isolated atrial ectopic beats (more than 700 per day).
If medical therapy fails to convert atrial fibrillation, electrical cardioversion, either externally or via an implanted device, can be attempted using 100 to 200 W-s of energy. Anticoagulation is usually recommended to reduce the incidence of embolization associated with cardioversion. Current recommendations suggest long-term anticoagulation for 3 to 4 weeks before cardioversion and 2 to 4 weeks following cardioversion.
Other treatment options for atrial fibrillation include catheter ablation of the atrioventricular (AV) node with pacemaker implantation, or modification of the AV node without pacemaker implantation. However, thromboembolic risk is unchanged and atrial systole is not restored with these procedures. Several alternatives have also been available to interrupt the reentrant wavelets, including extensive surgical, or recently, catheter-medicated atriotomy. Using the current techniques, the success rate of catheter ablation of other sustained atrial arrhythmias, e.g., atrial flutter and sustained atrial tachycardia, has been over 90%. Catheter ablation therefore represents an important alternative to pharmacologic therapy for treatment of atrial fibrillation and other sustained atrial arrhythmias.
In order to ablate the ectopic foci, electrophysiologic study (EPS) is required to locate the foci responsible for triggering of atrial fibrillation. According to Haissaguerre, et al., The New England Journal of Medicine (1998), vol. 339, No. 10, p. 659-666, incorporated herein by reference in its entirety, three multi-electrode catheters are introduced percutaneously through the femoral veins: one catheter for ablation, one mapping catheter for positioning in the right atrial appendage (for locating ectopic foci in the right atrial and right pulmonary vein) or coronary sinus (for locating ectopic foci in the left pulmonary vein), and another catheter for stimulation of the atrial tissue to induce atrial fibrillation. In this study, patients with paroxysmal atrial fibrillation were found to have ectopic beats originating in the atrial muscle ("atrial foci") and in pulmonary veins (the left superior, left inferior, right superior, and right inferior pulmonary veins). Direct mapping and ablation of the left atrium and pulmonary veins were performed via a trans- septal approach through the foramen ovale which lies in the interatrial septum. Alternatively, the catheters may be inserted retrograde in the aorta through the aortic valve and left ventricle. The ablation was performed at the site with earliest recorded ectopic activity. The ablative techniques used to restore normal sinus rhythm, where the tissue surface is subjected to extreme localized temperature designed to kill cellular structures, can generate necrotic tissue fragments or blood clots. These tissue debris or thrombi may travel downstream from the procedural site to lodge in other organs, causing stroke, myocardial infarction, renal infarcts, and tissue ischemia in other organs. New devices and methods are thus needed for an ablation catheter having an ability to entrap and/or remove embolic debris generated during ablation of ectopic atrial foci in patients with atrial fibrillation or other sustained atrial arrhythmias, thereby reducing the risk of embolization.
Summary of the Invention
It is known that patients with drug and cardioversion refractory paroxysmal atrial fibrillation and other sustained atrial arrhythmias, e.g., atrial flutter and sustained atrial tachycardia, may benefit from catheter ablation of ectopic atrial foci. The present invention provides devices and methods which include filtering and aspiration capabilities for trapping and removing necrotic tissue debris and thrombi generated during the ablative therapy, thereby minimizing embolization to other organs.
In one embodiment, the medical device comprises a catheter which includes a flexible elongate member having a distal end adapted to enter a vessel and a proximal end which extends from a patient's vessel and permits control outside the patient's body by a physician. At the distal end of the catheter is provided an ablation device and an expandable trapping mechanism. The ablation device may utilize radio frequency, laser, cryogenic, or microwave. The trapping mechanism, in certain embodiments, comprises an open-ended tubular member which extends to the proximal region of the catheter and is attached to a vacuum. In other embodiments, the trapping mechanism comprises a basket or opening in a tube, which is mounted proximal to the ablation device and surrounds the ablation device.
In another embodiment, the catheter may include a filtration mesh, typically disposed circumferentially about a distal region of the catheter proximal to the ablation device, so that filtration occurs downstream of the ablation. The filter will typically include a continuous mesh having a proximal edge circumferentially in contact with the outer surface of the catheter and a distal edge attached to an expansion mechanism, which contracts and expands radially outward. The construction and use of expansion means and associated filter mesh on a cannula have been thoroughly discussed in our earlier applications, including Barbut et al., U.S. Application Serial No., U.S. Application Serial No. 08/553,137, filed November 7, 1995, Barbut et al., U.S. Application Serial No. 08/580,223, filed December 28, 1995, Barbut et al., U.S.
Application Serial No. 08/584,759, filed January 9, 1996, Barbut et al., U.S. Patent No. 5,769,816, and Barbut et al., U.S. Application Serial No. 08/645,762, filed May 14, 1996, Barbut et al., U.S. Patent No. 5,662,671, Maahs, U.S. Patent No. 5,846,260, and Tsugita et al., U.S. Patent No. 5,911,734, all of which are incorporated herein by reference in their entirety.
In still another embodiment, the catheter includes a second lumen communicating with a proximal end and an aspiration port at its distal end. The proximal end of the catheter is adapted for attachment to a vacuum. The port is located distal to the trapping mechanism and proximal to the ablation device for removing tissue debris generated during the ablation.
In still another embodiment, the device comprises a flexible elongate tube having a lumen communicating with a proximal end and a distal end. An expandable entrapping mechanism is mounted on a distal region of the catheter. An ablation catheter, which includes an ablation device at its distal end, is disposed within the lumen of the catheter. In certain embodiments, the catheter may include a second lumen communicating with a distal port adapted for aspiration of tissue debris. The methods of the present invention protect a patient from embolization during ablative procedures to remove ectopic atrial foci in the right atrium, the left atrium, and/or the pulmonary veins. Using the devices described above, the distal end of the catheter is inserted percutaneously through a peripheral vein, e.g., the femoral vein, the brachial vein, the subclavian vein, or the internal/external jugular vein, into the right atrium. To ablate the ectopic foci in the right atrial appendage, the ablation device is positioned adjacent to the foci, and the entrapping mechanism, or filter, is expanded. During the ablation, necrotic tissue particles and/or thrombi generated are captured by the filter and/or removed by aspiration. To ablate the ectopic foci in the left atrial tissue or the pulmonary veins, the distal end of the catheter is advanced from the right atrium, through the foramen ovale, and enters the left atrium. Alternatively, the distal end of the catheter may be inserted percutaneously through a peripheral artery, e.g., the femoral artery, the brachial artery, the subclavian artery, or the axillary artery, retrograde into the aorta, the left ventricle, and the left atrium to access the foci in the left atrium or the pulmonary vein. It will be understood that the devices and methods can also be employed in an open surgical procedure (Maze technique).
In another method, after the ectopic atrial foci are located by electrophysiologic mapping, the distal end of the flexible guiding catheter carrying the filter at its distal region is inserted downstream the site of ablation. The filter is expanded. A steerable ablation catheter, having an ablation device mounted at its distal end, is inserted in the lumen of the guiding catheter to ablate the ectopic foci.
After the embolic tissue debris are entrapped by the filter, the filter is contracted to resume a small shape in close contact with the outer surface of the catheter. The catheter, with captured embolic material, is then withdrawn from the aorta or the vein and removed from the patient's body.
The devices and methods disclosed herein are best used in preventing peripheral embolization during ablation of ectopic foci in the right atrium, the left atrium, and the pulmonary veins in patients with atrial fibrillation or other sustained atrial arrhythmias. It will be understood that the devices and methods are applicable to ablating ectopic tissues in other cardiac arrhythmias, such as ventricular tachycardia or Wolff- Parkinson- White syndrome.
Brief Description of the Drawings
Fig. 1 depicts a normal cardiac conduction pathway.
Fig. 2A depicts an embodiment of an ablation catheter having a trapping mechanism for capturing emboli, comprising a filtration assembly in a contracted state.
Fig. 2B depicts the catheter of Fig. 2A having the filtration assembly in an expanded state.
Fig. 3 depicts the ablation catheter of Fig. 2B inserted in the right atrium. Fig. 4 depicts another embodiment of the ablation catheter having an aspiration port.
Fig. 5 depicts the device of Fig. 4 inserted in the pulmonary vein. Fig. 6A depicts an embodiment of a guiding catheter system for ablation of ectopic foci having a filtration assembly in a contracted state. Fig. 6B depicts the embodiment of Fig. 6 A having the filtration assembly in an expanded state.
Fig. 7 depicts another embodiment of the guiding catheter system for ablation of ectopic foci having an inflation seal.
Fig. 8 depicts the catheter system of Fig. 7 inserted in the aorta for ablating the ectopic foci in the pulmonary vein.
Fig. 9A depicts another embodiment of a trapping mechanism for capturing emboli, having a basket with an adjustable opening at a distal end.
Fig. 9B depicts the trapping mechanism of Fig. 9A in a collapsed condition. Fig. 10A depicts another embodiment of the trapping mechanism for capturing embolic material, having clamping fingers and associated mesh.
Fig. 10B depicts the trapping mechanism of Fig. 10A in an expanded state. Fig. 1 1 depicts various entry sites for catheter insertion.
Detailed Description
Normal cardiac conduction originates in sinoatrial (SA) node 1 10, located in the upper wall of right atrium 120 as depicted in Fig. 1. The SA node, the heart's main pacemaker, generates electrical activity which travels through a conduction pathway. Electrical impulses travel from SA node 1 10 over Bachmann's bundle 1 16 to left atrium 1 17, along anterior internodal tract 1 12, middle intemodal tract 1 13, and posterior internodal tract 114 in right atrium 120 to atrioventricular (AV) node 1 15. At the AV node the impulse is delayed for approximately 40 milliseconds, allowing atrial contraction, and resumes down through bundle of His 145. The electrical impulse travels rapidly into right bundle branch 125 and left bundle branch 140 and continues down the interventricular septum. From the bundle branches, the impulse continues through Purkinje fibers, which rapidly conduct the impulse to both ventricular endocardium. In this way, the electrical impulse generated from the SA node and terminating in the
Purkinje fibers constitutes a cardiac conduction cycle, triggering atrial and ventricular contraction and relaxation, causing the heart to pump blood. After right atrium 120 receives deoxygenated blood from superior vena cava (SVC) 101 and inferior vena cava (IVC) 102, the blood is passed through tricuspid valves 121 into right ventricle 122. The deoxygenated blood is ejected from the right ventricle into right pulmonary arteries 138 and left pulmonary arteries 139, oxygenated by the lung, and returned to left atrium 117 via right pulmonary veins 137 and left pulmonary veins 136. The oxygenated blood passes through mitral valve 130 into left ventricle 135, which ejects the blood into aorta 100 to perfuse the peripheral organs.
An embodiment of an ablation catheter with associated filter is depicted in Figs. 2A and 2B. The catheter includes a flexible elongate member 10 having a proximal end, distal end 12, ablation instrument 15 mounted at the distal end, and an expansion means, typically filtration assembly 20, mounted on distal region 13 of the catheter. The filtration assembly includes proximal edge 21 circumferentially in contact with an outer surface of the catheter and distal edge 22 which expands radially outward. Filter mesh 25 is associated with the outer surface of the catheter at proximal edge 21 and is operably connected to the filter assembly at distal edge 22. Having the filter assembly in a contracted state as depicted in Fig. 2 A facilitates insertion of the catheter into a peripheral vessel, such as the femoral vein or artery. After the distal end of the catheter is positioned in an area of interest, filter assembly 20 is expanded as depicted in Fig. 2B to capture embolic debris. Alternative expansion means based on a mechanical expanding mechanism similar to an umbrella frame are described in U.S. application Ser. Nos.
08/553,137, 08/580,223, 08/584,759, 08/640,015, and 08/645,762, incorporated herein by reference in their entirety.
In using the ablation catheter of Figs. 2 A and 2B to ablate ectopic right atrial foci for treatment of atrial fibrillation or other sustained atrial tachycardia, the distal end of the catheter can be inserted through a peripheral vein, e.g., the subclavian vein or the internal jugular vein, and through the superior vena cava to insert into the right atrium. Alternatively, distal end 13 of the catheter is inserted through the femoral artery and up through inferior vena cava 102 into right atrium 120 as depicted in Fig. 3. Filtration assembly 20 is contracted at distal region 13 to facilitate catheter insertion. After ectopic atrial foci are located with EPS, ablation instrument 15 is position adjacent to the affected atrial tissue. Filtration assembly 20 is expanded about distal end 12 of the catheter. The ectopic foci can be ablated using radio frequency, microwave, laser, or cryogenic techniques. Necrotic tissue debris or thrombi generated during the ablation procedure are captured by mesh 25. After the completion of the procedure, filtration assembly is contracted, securing the embolic material in the mesh, and removed when the catheter is withdrawn proximally, preventing distal embolization. Another embodiment of the ablation catheter having aspiration port 30 communicating with lumen 31 is depicted in Fig. 4. Lumen 31 at its proximal end is adapted for attachment to a vacuum. The aspiration port is capable of removing myocardial tissue debris or thrombi generated during the ablative procedure under suction. In this embodiment, filtration assembly 20 is mounted on distal region 13 of the catheter, proximal to distal end 12 and ablation instrument 15.
Using the ablation catheter of Fig. 4 may be preferred for ablation of pulmonary veins. In Fig. 5, distal end 12 of the catheter and the contracted filtration assembly are inserted through a peripheral artery, such as the femoral artery, up through aorta 100, and traverses left ventricle 135, mitral valve 130, and left atrium 117 to insert in left pulmonary vein 136. Alternatively, distal end 12 of the catheter can be inserted through the brachial or the subclavian artery to insert in pulmonary vein 136 via aorta 100 in a retrograde fashion. Alternatively, the catheter can be inserted through a peripheral vein to enter into right atrium 120 via SVC 101 or IVC 102, and insert in pulmonary vein 136 by traversing the foramen ovale, which is patent in some patients, to enter left atrium 1 17. After ectopic foci are located in the pulmonary vein, ablation assembly 20 is expanded circumferentially to contact the walls of the pulmonary vein. During the ablation of the ectopic foci by ablation instrument 15, necrotic tissue debris and thrombi generated can be aspirated by the aspiration port at distal end 12 of the catheter or can be captured by the expanded filtration assembly. After completion of the ablative procedure, the filtration assembly is contracted and removed with the catheter, thereby preventing the emboli from entering left atrium 1 17, through mitral valve 130, left ventricle 135, and exiting aorta 100 downstream to lodge in the peripheral organs.
An embodiment of a percutaneous guiding catheter system for ablation of ectopic foci is shown in Figs. 6A and 6B. The catheter system includes elongate tubular member 10 having lumen 1 1 communicating with a proximal end and distal port 12. The lumen is adapted for insertion of an ablation catheter having an ablation instrument at its distal end. The lumen may also accommodate other interventional catheters, e.g., an atherectomy catheter. Expandable filtration assembly 20 is mounted on distal region 13 of the catheter. The assembly includes proximal edge 21 circumferentially in contact with an outer surface of the catheter, and distal edge 22 which expands radially outward as depicted in Fig. 6B. The catheter further includes a second lumen 31 communicating with aspiration port 30, and a proximal end which is adapted for attachment to a vacuum. The aspiration port is capable of removing embolic material generated by the ablation instrument under suction. In certain embodiments, as depicted in Fig. 7, filtration assembly 20 comprises inflation seal 40 disposed about distal region 13 of the catheter, wherein the inflation seal is expandable between a contracted condition and an enlarged condition. Inflation seal 40 comprises a continuous ring of thin tubing attached to filter mesh 25, which is operably connected to the inflation seal at proximal edge 21 and is closely associated with the outer surface of the catheter at distal edge 22. The inflation seal may be constructed from elastomeric or non-elastomeric tubular material which encloses a donut-shaped chamber 41. When deployed, the inflation seal can be expanded by injecting fluid or gas into chamber 41 to fit tightly against the lumen of a vessel. Chamber 41 is in fluid communication with first tubular passage 56 and second tubular passage 57 which permit chamber 41 to be inflated with gas, or preferably a fluid such as saline. Distal region 13 of the catheter may include a plurality of spokes or folding strings 55 made form Dacron® or other suitable material. Holding strings 55 connect distal region 13 of the catheter to inflation seal 40. The construction and operation of the inflation seal are described in more details in Barbut, et al., U.S. Pat No. 5,662,671, incorporated herein by reference in its entirety.
In a contracted condition, for example, inflation seal 40 and mesh 25 can be inserted through the femoral artery and up through aorta 100 as depicted in Fig. 8. An ablation catheter having ablation instrument 15 at its distal end is disposed in lumen 1 1 of the catheter, and is advanced distally through port 30 to position in pulmonary vein 136 after traversing aortic valve 150 and mitral valve 130. Inflation seal 40 is then expanded by injecting fluid or gas into inflation seal 40 to achieve contact with the inner lumen of aorta 100. In this way, embolic material traveling downstream from the pulmonary vein, left atrium 1 17, and left ventricle 135 during the ablation procedure is captured by filtration assembly 20 positioned in the ascending aorta, thereby preventing movement of the emboli downstream to other organs. Figs. 9A and 9B depict an alternative embodiment of the emboli trapping mechanism having basket 50 with an adjustable opening at distal end 12 of the ablation or guiding catheter. In Fig. 9A, basket 50 is attached at seam 52 to distal end 12 of the catheter. Distal region 53 of basket 50 is attached to a contracting loop or inflation member 55 which is secured to the catheter by support wires 56. In use, contracting loop 55 is narrowed as shown in Fig. 9B during catheter insertion, and expanded thereafter to receive embolic material through distal opening 59. After basket 50 receives necrotic tissue or thrombi generated during the ablation procedure, loop 55 is narrowed about the embolic material, which is securely retained by basket 50 and removed when the catheter is withdrawn. Another embodiment of the trapping mechanism is depicted in Figs. 10A and 10B. Distal end 12 of catheter 10 includes a plurality of clamping fingers 60 which are operable between an open and closed condition. Filtration mesh 25 is disposed over fingers 60 and is positioned to capture embolic material dislodged during the ablative procedure. Ablation catheter 16 having ablation instrument 15 at its distal end is moveably inserted in lumen 11 of catheter 10. In certain embodiments, ablation catheter 16 may include an aspiration lumen and distal aspiration port. In use, catheter 10 approaches the ectopic focus with open fingers 60 as shown in Fig. 10B. Ablation instrument 15 is positioned adjacent to the ectopic focus having fingers 60 and mesh 25 closed about the ablation catheter. Embolic material generated during the ablative procedure is captured by mesh 25.
A variety of entry sites available for insertion of the ablation catheter from peripheral arteries and veins into the cardiac chambers or the great vessels are shown in Fig. 1 1. For ablating ectopic atrial foci located in the right atrial appendage, the ablation catheter 10 can be inserted through right subclavian vein 342, left subclavian vein 340, right internal jugular vein 332, left internal jugular vein 330, right external jugular vein 336, left external jugular vein 334, right median cubital vein 312, or left median cubital vein 310, and through superior vena cava (SVC) to insert in the right atrium (RA).
Alternatively, the catheter can be inserted through right femoral vein 322 or left femoral vein 320 and up through the inferior vena cava (IVC) to insert in the RA. Fig. 11 depicts catheter 10 entering the RA through right femoral vein 322 and right subclavian vein 342. Entrapping mechanism 20 is positioned in the RA. For ablating ectopic foci located in the left atrium (LA) or the pulmonary veins (PV), the catheter can be inserted through right brachial artery 212, left brachial artery 210, right axillary artery 226, left axillary artery 225, right subclavian artery 242, or left subclavian artery 240 and through the aorta to enter the LA or the PV. Alternatively, the catheter can be inserted through right femoral artery 222 or the left femoral artery 220, and up through the descending aorta to enter the LA or the PV. Fig. 11 depicts catheter 10 inserted through left femoral artery 220 and left subclavian artery 240. Entrapping mechanism 20 is positioned in the ascending aorta to prevent emboli from traveling downstream in the aorta. Alternatively, ablation of ectopic foci in the LA or the PV can be achieved by a trans-septal approach, having the catheter traversing through the foramen ovale from the RA to the LA. In this approach, the catheter is inserted through the peripheral veins.
The length of catheter will generally be between 10 and 200 centimeters, preferably approximately between 30 and 150 centimeters. The inner diameter of the catheter lumen will generally be between 0.2 and 0.8 centimeters, preferably between approximately 0.3 and 0.5 centimeters. The mesh permits flow rates as high as 3L/min or more, more preferably 3.5 L/min or more, more preferably 4 L/min or more, more preferably 4.5 L/min or more, more preferably 5 L/min or more, more preferably 5.5 L/min or more, most preferably at 6 L/min or more at pre-filter maximum aortic systolic pressures (proximal to the mesh) of around 200 mmHg or less. The outer diameter of the expanded inflation seal will generally be at least 1 centimeters, more preferably at least 1.5 centimeters, more preferably at least 2 centimeters, more preferably at least 2.5 centimeters, more preferably at least 3 centimeters, more preferably at least 3.5 centimeters, more preferably at least 4 centimeters, more preferably at least 4.5 centimeters, more preferably at least 5 centimeters, more preferably at least 5.5 centimeters, more preferably at least 6 centimeters, more preferably at least 6.5 centimeters, more preferably at least 7 centimeters, more preferably at least 7.5 centimeters, more preferably at least 8 centimeters, more preferably at least 8.5 centimeters, more preferably at least 9 centimeters, more preferably at least 9.5 centimeters, more preferably at least 10 centimeters, more preferably at least 10.5 centimeters, more preferably at least 11 centimeters, more preferably at least 11.5 centimeters, more preferably at least 12 0 centimeters These ranges cover suitable diameters in the aorta and the pulmonary veins for both pediatπc and adult use The foregoing ranges are set forth solely for the purpose of illustrating typical device dimensions The actual dimensions of a device constructed according to the pπnciples of the present invention may obviously vary outside of the listed ranges without departing from those basic pπnciples
Although the foregoing invention has, for the purposes of claπty and understanding, been descπbed in some detail by way of illustration and example, it will be obvious that certain changes and modifications may be practiced which will still fall within the scope of the appended claims

Claims

What is claimed is:
1. A percutaneous catheter for ablation of ectopic foci, comprising: an elongate member having a proximal end, a distal end, and an ablation instrument mounted at the distal end of the elongate member; and an expandable filter mounted on a distal region of the elongate member, wherein during use, the catheter is operated to ablate ectopic foci and the filter is expanded to capture necrosed tissue particles generated during the ablation.
2. The catheter of claim 1 , wherein the ablation instrument is a thermal ablation.
3 The catheter of claim 1, wherein the ablation instrument is a laser ablation device.
4. The catheter of claim 1, wherein the ablation instrument is a microwave ablation device.
5. The catheter of claim 1, wherein the filter surrounds the ablation instrument.
6. The catheter of claim 1, wherein the filter is disposed proximal the ablation instrument.
7. The catheter of claim 6, wherein the filter has a proximal edge circumferentially in contact with an outer surface of the elongate member, and a distal edge which expands radially outward.
8. The catheter of claim 1, wherein the catheter includes a second lumen communicating with an aspiration port.
9. The catheter of claim 1, wherein the filter may be a basket.
10. A percutaneous guiding catheter system for ablation of ectopic foci, comprising: an elongate member having a proximal end, a distal end, and a lumen therebetween; an expandable filter mounted on a distal region of the elongate member; and an ablation catheter disposed within the lumen of the elongate member, and having an ablation instrument at its distal end.
1 1. The catheter of claim 10, wherein the ablation instrument is a thermal ablation.
12. The catheter of claim 10, wherein the ablation instrument is a laser ablation device.
13. The catheter of claim 10, wherein the ablation instrument is a microwave ablation device.
14. The catheter of claim 10, wherein the ablation instrument extends beyond the distal end of the elongate member.
15. The catheter of claim 10, wherein the catheter includes a second lumen communicating with an aspiration port.
16. The catheter of claim 10, wherein the filter has a proximal edge circumferentially in contact with an outer surface of the elongate member, and a distal edge which expands radially outward.
17. The catheter of claim 10, wherein the proximal end of the catheter is adapted for attachment to a vacuum.
18. The catheter of claim 10, wherein the filter is a basket.
19. A method for ablation of ectopic foci, comprising the steps of: providing a catheter having a proximal end, a distal end, an ablation instrument at the distal end, and a filter on a distal region of the elongate member; inserting the catheter into a vessel; positioning the ablation instrument adjacent the ectopic foci; expanding the filter; and ablating the ectopic foci, wherein necrosed tissue particles generated during ablation are captured by the filter.
20. The method of claim 19, wherein the ectopic foci are located in the left atrium.
21. The method of claim 19, wherein the ectopic foci are located in the right atrium.
22. The method of claim 19, wherein the ectopic foci are located in the pulmonary vein.
23. The method of claim 19, wherein the ablation instrument is a thermal ablation.
24. The method of claim 19, wherein the ablation instrument is a laser ablation device.
25. The method of claim 19, wherein the ablation instrument is a microwave ablation device.
26. The method of claim 19, wherein the filter surrounds the ablation instrument.
27. The method of claim 19, wherein the filter is disposed proximal the ablation instrumenL
28. The method of claim 27, wherein the filter has a proximal edge circumferentially in contact with an outer surface of the catheter, and a distal edge which expands radially outward.
29. The method of claim 19, wherein the catheter is inserted into the femoral artery.
30. The method of claim 19, wherein the catheter is inserted into the right subclavian artery.
31. The method of claim 19, wherein the catheter is inserted into the left subclavian arteiy.
32. The method of claim 19, wherein the filter is mounted on a sheath having a lumen which carries the catheter having the ablation instrument.
33. The method of claim 19, wherein the catheter includes a lumen communicating with an aspiration port at the distal end.
34. The method of claim 19, wherein the catheter is inserted into the femoral vein.
35. The method of claim 19, wherein the catheter is inserted into the subclavian vein.
36. The method of claim 34, further comprising the step of aspirating necrosed tissue from the aspiration port.
PCT/US2000/021242 1999-08-04 2000-08-03 Percutaneous catheter and guidewire for filtering during ablation of myocardial or vascular tissue WO2001010320A1 (en)

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CA2378594A CA2378594C (en) 1999-08-04 2000-08-03 Percutaneous catheter and guidewire for filtering during ablation of myocardial or vascular tissue
DE60020404T DE60020404D1 (en) 1999-08-04 2000-08-03 PERKUTANE CATHETER AND GUIDE WIRE FOR FILTRATION DURING MYOCARDIAL OR VASCULAR TISSUE ABLATION
EP00952473A EP1294299B1 (en) 1999-08-04 2000-08-03 Percutaneous catheter and guidewire for filtering during ablation of myocardial or vascular tissue
AT00952473T ATE296061T1 (en) 1999-08-04 2000-08-03 PERCUTANEOUS CATHETER AND GUIDE WIRE FOR FILTERING DURING MYOCARDIAL OR VASCULAR TISSUE ABLATION

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Cited By (83)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6814740B2 (en) 1999-10-27 2004-11-09 Scimed Life Systems, Inc. Retrieval device made of precursor alloy cable
US6974468B2 (en) 2001-02-28 2005-12-13 Scimed Life Systems, Inc. Filter retrieval catheter
US7712606B2 (en) 2005-09-13 2010-05-11 Sadra Medical, Inc. Two-part package for medical implant
US7748389B2 (en) 2003-12-23 2010-07-06 Sadra Medical, Inc. Leaflet engagement elements and methods for use thereof
US7780725B2 (en) 2004-06-16 2010-08-24 Sadra Medical, Inc. Everting heart valve
US7824442B2 (en) 2003-12-23 2010-11-02 Sadra Medical, Inc. Methods and apparatus for endovascularly replacing a heart valve
US7824443B2 (en) 2003-12-23 2010-11-02 Sadra Medical, Inc. Medical implant delivery and deployment tool
US7959666B2 (en) 2003-12-23 2011-06-14 Sadra Medical, Inc. Methods and apparatus for endovascularly replacing a heart valve
US7959672B2 (en) 2003-12-23 2011-06-14 Sadra Medical Replacement valve and anchor
US7988724B2 (en) 2003-12-23 2011-08-02 Sadra Medical, Inc. Systems and methods for delivering a medical implant
US7987994B2 (en) 2003-02-24 2011-08-02 Boston Scientific Scimed, Inc. Flexible tube for cartridge filter
US8007510B2 (en) 2003-02-24 2011-08-30 Boston Scientific Scimed, Inc. Embolic protection filtering device that can be adapted to be advanced over a guidewire
US8048153B2 (en) 2003-12-23 2011-11-01 Sadra Medical, Inc. Low profile heart valve and delivery system
US8231670B2 (en) 2003-12-23 2012-07-31 Sadra Medical, Inc. Repositionable heart valve and method
US8246678B2 (en) 2003-12-23 2012-08-21 Sadra Medicl, Inc. Methods and apparatus for endovascularly replacing a patient's heart valve
US8252052B2 (en) 2003-12-23 2012-08-28 Sadra Medical, Inc. Methods and apparatus for endovascularly replacing a patient's heart valve
US8267956B2 (en) 2001-10-19 2012-09-18 Incept, Llc Vascular embolic filter exchange devices and methods of use thereof
US8287584B2 (en) 2005-11-14 2012-10-16 Sadra Medical, Inc. Medical implant deployment tool
US8328868B2 (en) 2004-11-05 2012-12-11 Sadra Medical, Inc. Medical devices and delivery systems for delivering medical devices
USRE43882E1 (en) 1999-07-30 2012-12-25 Incept, Llc Vascular device for emboli, thrombus and foreign body removal and methods of use
US8343213B2 (en) 2003-12-23 2013-01-01 Sadra Medical, Inc. Leaflet engagement elements and methods for use thereof
US8579962B2 (en) 2003-12-23 2013-11-12 Sadra Medical, Inc. Methods and apparatus for performing valvuloplasty
US8603160B2 (en) 2003-12-23 2013-12-10 Sadra Medical, Inc. Method of using a retrievable heart valve anchor with a sheath
US8840663B2 (en) 2003-12-23 2014-09-23 Sadra Medical, Inc. Repositionable heart valve method
US8940014B2 (en) 2011-11-15 2015-01-27 Boston Scientific Scimed, Inc. Bond between components of a medical device
US8951243B2 (en) 2011-12-03 2015-02-10 Boston Scientific Scimed, Inc. Medical device handle
US8998976B2 (en) 2011-07-12 2015-04-07 Boston Scientific Scimed, Inc. Coupling system for medical devices
US9005273B2 (en) 2003-12-23 2015-04-14 Sadra Medical, Inc. Assessing the location and performance of replacement heart valves
US9011521B2 (en) 2003-12-23 2015-04-21 Sadra Medical, Inc. Methods and apparatus for endovascularly replacing a patient's heart valve
US9119706B2 (en) 1999-02-24 2015-09-01 Boston Scientific Scimed Inc. Intravascular filter and method
US9131926B2 (en) 2011-11-10 2015-09-15 Boston Scientific Scimed, Inc. Direct connect flush system
US9277993B2 (en) 2011-12-20 2016-03-08 Boston Scientific Scimed, Inc. Medical device delivery systems
US9301829B2 (en) 2003-07-30 2016-04-05 Boston Scientific Scimed, Inc. Embolic protection aspirator
US9415225B2 (en) 2005-04-25 2016-08-16 Cardiac Pacemakers, Inc. Method and apparatus for pacing during revascularization
US9510945B2 (en) 2011-12-20 2016-12-06 Boston Scientific Scimed Inc. Medical device handle
US9526609B2 (en) 2003-12-23 2016-12-27 Boston Scientific Scimed, Inc. Methods and apparatus for endovascularly replacing a patient's heart valve
US9788942B2 (en) 2015-02-03 2017-10-17 Boston Scientific Scimed Inc. Prosthetic heart valve having tubular seal
US20170325938A1 (en) 2016-05-16 2017-11-16 Boston Scientific Scimed, Inc. Replacement heart valve implant with invertible leaflets
US9861477B2 (en) 2015-01-26 2018-01-09 Boston Scientific Scimed Inc. Prosthetic heart valve square leaflet-leaflet stitch
US9901445B2 (en) 2014-11-21 2018-02-27 Boston Scientific Scimed, Inc. Valve locking mechanism
US10080652B2 (en) 2015-03-13 2018-09-25 Boston Scientific Scimed, Inc. Prosthetic heart valve having an improved tubular seal
US10136991B2 (en) 2015-08-12 2018-11-27 Boston Scientific Scimed Inc. Replacement heart valve implant
US10172708B2 (en) 2012-01-25 2019-01-08 Boston Scientific Scimed, Inc. Valve assembly with a bioabsorbable gasket and a replaceable valve implant
US10179041B2 (en) 2015-08-12 2019-01-15 Boston Scientific Scimed Icn. Pinless release mechanism
US10195392B2 (en) 2015-07-02 2019-02-05 Boston Scientific Scimed, Inc. Clip-on catheter
US10201417B2 (en) 2015-02-03 2019-02-12 Boston Scientific Scimed Inc. Prosthetic heart valve having tubular seal
US10201418B2 (en) 2010-09-10 2019-02-12 Symetis, SA Valve replacement devices, delivery device for a valve replacement device and method of production of a valve replacement device
US10245136B2 (en) 2016-05-13 2019-04-02 Boston Scientific Scimed Inc. Containment vessel with implant sheathing guide
US10258465B2 (en) 2003-12-23 2019-04-16 Boston Scientific Scimed Inc. Methods and apparatus for endovascular heart valve replacement comprising tissue grasping elements
US10278805B2 (en) 2000-08-18 2019-05-07 Atritech, Inc. Expandable implant devices for filtering blood flow from atrial appendages
US10285809B2 (en) 2015-03-06 2019-05-14 Boston Scientific Scimed Inc. TAVI anchoring assist device
US10299922B2 (en) 2005-12-22 2019-05-28 Symetis Sa Stent-valves for valve replacement and associated methods and systems for surgery
US10314695B2 (en) 2003-12-23 2019-06-11 Boston Scientific Scimed Inc. Methods and apparatus for endovascular heart valve replacement comprising tissue grasping elements
US10335277B2 (en) 2015-07-02 2019-07-02 Boston Scientific Scimed Inc. Adjustable nosecone
US10342660B2 (en) 2016-02-02 2019-07-09 Boston Scientific Inc. Tensioned sheathing aids
US10426617B2 (en) 2015-03-06 2019-10-01 Boston Scientific Scimed, Inc. Low profile valve locking mechanism and commissure assembly
US10449043B2 (en) 2015-01-16 2019-10-22 Boston Scientific Scimed, Inc. Displacement based lock and release mechanism
US10555809B2 (en) 2012-06-19 2020-02-11 Boston Scientific Scimed, Inc. Replacement heart valve
US10779940B2 (en) 2015-09-03 2020-09-22 Boston Scientific Scimed, Inc. Medical device handle
US10828154B2 (en) 2017-06-08 2020-11-10 Boston Scientific Scimed, Inc. Heart valve implant commissure support structure
US10898325B2 (en) 2017-08-01 2021-01-26 Boston Scientific Scimed, Inc. Medical implant locking mechanism
US10939996B2 (en) 2017-08-16 2021-03-09 Boston Scientific Scimed, Inc. Replacement heart valve commissure assembly
US10993805B2 (en) 2008-02-26 2021-05-04 Jenavalve Technology, Inc. Stent for the positioning and anchoring of a valvular prosthesis in an implantation site in the heart of a patient
US11065138B2 (en) 2016-05-13 2021-07-20 Jenavalve Technology, Inc. Heart valve prosthesis delivery system and method for delivery of heart valve prosthesis with introducer sheath and loading system
US11147668B2 (en) 2018-02-07 2021-10-19 Boston Scientific Scimed, Inc. Medical device delivery system with alignment feature
US11185405B2 (en) 2013-08-30 2021-11-30 Jenavalve Technology, Inc. Radially collapsible frame for a prosthetic valve and method for manufacturing such a frame
US11191641B2 (en) 2018-01-19 2021-12-07 Boston Scientific Scimed, Inc. Inductance mode deployment sensors for transcatheter valve system
US11229517B2 (en) 2018-05-15 2022-01-25 Boston Scientific Scimed, Inc. Replacement heart valve commissure assembly
US11241310B2 (en) 2018-06-13 2022-02-08 Boston Scientific Scimed, Inc. Replacement heart valve delivery device
US11241312B2 (en) 2018-12-10 2022-02-08 Boston Scientific Scimed, Inc. Medical device delivery system including a resistance member
US11246625B2 (en) 2018-01-19 2022-02-15 Boston Scientific Scimed, Inc. Medical device delivery system with feedback loop
US11278398B2 (en) 2003-12-23 2022-03-22 Boston Scientific Scimed, Inc. Methods and apparatus for endovascular heart valve replacement comprising tissue grasping elements
US11285002B2 (en) 2003-12-23 2022-03-29 Boston Scientific Scimed, Inc. Methods and apparatus for endovascularly replacing a heart valve
WO2022073922A1 (en) * 2020-10-08 2022-04-14 Biotronik Ag Catheter device for performing a cardiac sympathetic denervation intervention
US11337800B2 (en) 2015-05-01 2022-05-24 Jenavalve Technology, Inc. Device and method with reduced pacemaker rate in heart valve replacement
US11357624B2 (en) 2007-04-13 2022-06-14 Jenavalve Technology, Inc. Medical device for treating a heart valve insufficiency
US11382742B2 (en) 2016-05-13 2022-07-12 Boston Scientific Scimed, Inc. Medical device handle
US11439732B2 (en) 2018-02-26 2022-09-13 Boston Scientific Scimed, Inc. Embedded radiopaque marker in adaptive seal
US11439504B2 (en) 2019-05-10 2022-09-13 Boston Scientific Scimed, Inc. Replacement heart valve with improved cusp washout and reduced loading
US11517431B2 (en) 2005-01-20 2022-12-06 Jenavalve Technology, Inc. Catheter system for implantation of prosthetic heart valves
US11564794B2 (en) 2008-02-26 2023-01-31 Jenavalve Technology, Inc. Stent for the positioning and anchoring of a valvular prosthesis in an implantation site in the heart of a patient
US11589981B2 (en) 2010-05-25 2023-02-28 Jenavalve Technology, Inc. Prosthetic heart valve and transcatheter delivered endoprosthesis comprising a prosthetic heart valve and a stent
US11771544B2 (en) 2011-05-05 2023-10-03 Symetis Sa Method and apparatus for compressing/loading stent-valves

Families Citing this family (390)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6974469B2 (en) * 1997-03-06 2005-12-13 Scimed Life Systems, Inc. Distal protection device and method
US5814064A (en) * 1997-03-06 1998-09-29 Scimed Life Systems, Inc. Distal protection device
US6676682B1 (en) * 1997-05-08 2004-01-13 Scimed Life Systems, Inc. Percutaneous catheter and guidewire having filter and medical device deployment capabilities
US6066149A (en) * 1997-09-30 2000-05-23 Target Therapeutics, Inc. Mechanical clot treatment device with distal filter
US7287398B2 (en) * 2001-09-25 2007-10-30 Alsius Corporation Heating/cooling system for indwelling heat exchange catheter
US20020138094A1 (en) * 1999-02-12 2002-09-26 Thomas Borillo Vascular filter system
US20030150821A1 (en) * 1999-07-16 2003-08-14 Bates Mark C. Emboli filtration system and methods of use
US7320697B2 (en) * 1999-07-30 2008-01-22 Boston Scientific Scimed, Inc. One piece loop and coil
US6620182B1 (en) 1999-07-30 2003-09-16 Incept Llc Vascular filter having articulation region and methods of use in the ascending aorta
CA2379414C (en) 1999-07-30 2010-09-14 Incept Llc Vascular filter having articulation region and methods of use in the ascending aorta
US6616679B1 (en) 1999-07-30 2003-09-09 Incept, Llc Rapid exchange vascular device for emboli and thrombus removal and methods of use
US7306618B2 (en) * 1999-07-30 2007-12-11 Incept Llc Vascular device for emboli and thrombi removal and methods of use
US6589263B1 (en) 1999-07-30 2003-07-08 Incept Llc Vascular device having one or more articulation regions and methods of use
US6530939B1 (en) 1999-07-30 2003-03-11 Incept, Llc Vascular device having articulation region and methods of use
US6142987A (en) * 1999-08-03 2000-11-07 Scimed Life Systems, Inc. Guided filter with support wire and methods of use
US6235044B1 (en) * 1999-08-04 2001-05-22 Scimed Life Systems, Inc. Percutaneous catheter and guidewire for filtering during ablation of mycardial or vascular tissue
US6371971B1 (en) * 1999-11-15 2002-04-16 Scimed Life Systems, Inc. Guidewire filter and methods of use
US6402771B1 (en) 1999-12-23 2002-06-11 Guidant Endovascular Solutions Snare
US6660021B1 (en) 1999-12-23 2003-12-09 Advanced Cardiovascular Systems, Inc. Intravascular device and system
US6575997B1 (en) 1999-12-23 2003-06-10 Endovascular Technologies, Inc. Embolic basket
US6540722B1 (en) * 1999-12-30 2003-04-01 Advanced Cardiovascular Systems, Inc. Embolic protection devices
US6695813B1 (en) 1999-12-30 2004-02-24 Advanced Cardiovascular Systems, Inc. Embolic protection devices
US7918820B2 (en) 1999-12-30 2011-04-05 Advanced Cardiovascular Systems, Inc. Device for, and method of, blocking emboli in vessels such as blood arteries
US20040167567A1 (en) * 2001-03-23 2004-08-26 Cano Gerald G. Method and apparatus for capturing objects beyond an operative site in medical procedures
GB2369575A (en) * 2000-04-20 2002-06-05 Salviac Ltd An embolic protection system
US7534242B2 (en) * 2003-02-25 2009-05-19 Artemis Medical, Inc. Tissue separating catheter assembly and method
US6939362B2 (en) * 2001-11-27 2005-09-06 Advanced Cardiovascular Systems, Inc. Offset proximal cage for embolic filtering devices
US6964670B1 (en) * 2000-07-13 2005-11-15 Advanced Cardiovascular Systems, Inc. Embolic protection guide wire
JP2004508879A (en) * 2000-09-21 2004-03-25 アトリテック, インコーポレイテッド Apparatus for implanting a device in the atrial appendage
US6616681B2 (en) 2000-10-05 2003-09-09 Scimed Life Systems, Inc. Filter delivery and retrieval device
US6537294B1 (en) * 2000-10-17 2003-03-25 Advanced Cardiovascular Systems, Inc. Delivery systems for embolic filter devices
US6893451B2 (en) * 2000-11-09 2005-05-17 Advanced Cardiovascular Systems, Inc. Apparatus for capturing objects beyond an operative site utilizing a capture device delivered on a medical guide wire
US6506203B1 (en) 2000-12-19 2003-01-14 Advanced Cardiovascular Systems, Inc. Low profile sheathless embolic protection system
US6936059B2 (en) * 2001-01-16 2005-08-30 Scimed Life Systems, Inc. Endovascular guidewire filter and methods of use
US7169165B2 (en) * 2001-01-16 2007-01-30 Boston Scientific Scimed, Inc. Rapid exchange sheath for deployment of medical devices and methods of use
US6689151B2 (en) * 2001-01-25 2004-02-10 Scimed Life Systems, Inc. Variable wall thickness for delivery sheath housing
US6840950B2 (en) * 2001-02-20 2005-01-11 Scimed Life Systems, Inc. Low profile emboli capture device
US20020123755A1 (en) * 2001-03-01 2002-09-05 Scimed Life Systems, Inc. Embolic protection filter delivery sheath
US7226464B2 (en) * 2001-03-01 2007-06-05 Scimed Life Systems, Inc. Intravascular filter retrieval device having an actuatable dilator tip
US6508826B2 (en) * 2001-04-30 2003-01-21 Embol-X, Inc. Cannula with flow diversion mechanism and methods of use
US6645223B2 (en) * 2001-04-30 2003-11-11 Advanced Cardiovascular Systems, Inc. Deployment and recovery control systems for embolic protection devices
US6929652B1 (en) * 2001-06-01 2005-08-16 Advanced Cardiovascular Systems, Inc. Delivery and recovery systems having steerability and rapid exchange operating modes for embolic protection systems
EP1392394A4 (en) * 2001-06-04 2005-05-18 Albert Einstein Healthcare Network Cardiac stimulating apparatus having a blood clot filter and atrial pacer
US6623506B2 (en) * 2001-06-18 2003-09-23 Rex Medical, L.P Vein filter
US6793665B2 (en) * 2001-06-18 2004-09-21 Rex Medical, L.P. Multiple access vein filter
US7179275B2 (en) * 2001-06-18 2007-02-20 Rex Medical, L.P. Vein filter
US8282668B2 (en) * 2001-06-18 2012-10-09 Rex Medical, L.P. Vein filter
AU2002312441B8 (en) * 2001-06-18 2008-08-21 Rex Medical, L.P. Vein Filter
US6783538B2 (en) 2001-06-18 2004-08-31 Rex Medical, L.P Removable vein filter
US6599307B1 (en) * 2001-06-29 2003-07-29 Advanced Cardiovascular Systems, Inc. Filter device for embolic protection systems
US7338510B2 (en) 2001-06-29 2008-03-04 Advanced Cardiovascular Systems, Inc. Variable thickness embolic filtering devices and method of manufacturing the same
US6997939B2 (en) * 2001-07-02 2006-02-14 Rubicon Medical, Inc. Methods, systems, and devices for deploying an embolic protection filter
US6951570B2 (en) * 2001-07-02 2005-10-04 Rubicon Medical, Inc. Methods, systems, and devices for deploying a filter from a filter device
US6962598B2 (en) * 2001-07-02 2005-11-08 Rubicon Medical, Inc. Methods, systems, and devices for providing embolic protection
US20030032941A1 (en) * 2001-08-13 2003-02-13 Boyle William J. Convertible delivery systems for medical devices
US6652557B1 (en) * 2001-08-29 2003-11-25 Macdonald Kenneth A. Mechanism for capturing debris generated during vascular procedures
US6638294B1 (en) 2001-08-30 2003-10-28 Advanced Cardiovascular Systems, Inc. Self furling umbrella frame for carotid filter
US6592606B2 (en) 2001-08-31 2003-07-15 Advanced Cardiovascular Systems, Inc. Hinged short cage for an embolic protection device
US6878151B2 (en) * 2001-09-27 2005-04-12 Scimed Life Systems, Inc. Medical retrieval device
US8262689B2 (en) 2001-09-28 2012-09-11 Advanced Cardiovascular Systems, Inc. Embolic filtering devices
US6755847B2 (en) * 2001-10-05 2004-06-29 Scimed Life Systems, Inc. Emboli capturing device and method of manufacture therefor
US20030069597A1 (en) * 2001-10-10 2003-04-10 Scimed Life Systems, Inc. Loading tool
US20030078614A1 (en) * 2001-10-18 2003-04-24 Amr Salahieh Vascular embolic filter devices and methods of use therefor
US20030083692A1 (en) * 2001-10-29 2003-05-01 Scimed Life Systems, Inc. Distal protection device and method of use thereof
AU2002352628B2 (en) 2001-11-09 2006-06-29 Rubicon Medical, Inc. Stent delivery device with embolic protection
US6793666B2 (en) * 2001-12-18 2004-09-21 Scimed Life Systems, Inc. Distal protection mechanically attached filter cartridge
US7241304B2 (en) 2001-12-21 2007-07-10 Advanced Cardiovascular Systems, Inc. Flexible and conformable embolic filtering devices
US8647359B2 (en) 2002-01-10 2014-02-11 Boston Scientific Scimed, Inc. Distal protection filter
US20030135162A1 (en) * 2002-01-17 2003-07-17 Scimed Life Systems, Inc. Delivery and retrieval manifold for a distal protection filter
US6997938B2 (en) * 2002-02-12 2006-02-14 Scimed Life Systems, Inc. Embolic protection device
US7118539B2 (en) * 2002-02-26 2006-10-10 Scimed Life Systems, Inc. Articulating guide wire for embolic protection and methods of use
US7029440B2 (en) * 2002-03-13 2006-04-18 Scimed Life Systems, Inc. Distal protection filter and method of manufacture
US7060082B2 (en) 2002-05-06 2006-06-13 Scimed Life Systems, Inc. Perfusion guidewire in combination with a distal filter
US8070769B2 (en) 2002-05-06 2011-12-06 Boston Scientific Scimed, Inc. Inverted embolic protection filter
US7585309B2 (en) * 2002-05-16 2009-09-08 Boston Scientific Scimed, Inc. Aortic filter
US7001406B2 (en) * 2002-05-23 2006-02-21 Scimed Life Systems Inc. Cartridge embolic protection filter and methods of use
US7959584B2 (en) * 2002-05-29 2011-06-14 Boston Scientific Scimed, Inc. Dedicated distal protection guidewires
US7326224B2 (en) * 2002-06-11 2008-02-05 Boston Scientific Scimed, Inc. Shaft and wire lock
US6887258B2 (en) * 2002-06-26 2005-05-03 Advanced Cardiovascular Systems, Inc. Embolic filtering devices for bifurcated vessels
US7172614B2 (en) * 2002-06-27 2007-02-06 Advanced Cardiovascular Systems, Inc. Support structures for embolic filtering devices
US7174636B2 (en) * 2002-09-04 2007-02-13 Scimed Life Systems, Inc. Method of making an embolic filter
US7115138B2 (en) * 2002-09-04 2006-10-03 Boston Scientific Scimed, Inc. Sheath tip
US20040064099A1 (en) * 2002-09-30 2004-04-01 Chiu Jessica G. Intraluminal needle injection substance delivery system with filtering capability
US7252675B2 (en) 2002-09-30 2007-08-07 Advanced Cardiovascular, Inc. Embolic filtering devices
US7331973B2 (en) 2002-09-30 2008-02-19 Avdanced Cardiovascular Systems, Inc. Guide wire with embolic filtering attachment
US20040093011A1 (en) * 2002-10-01 2004-05-13 Scimed Life Systems, Inc. Embolic protection device with lesion length assessment markers
US7998163B2 (en) 2002-10-03 2011-08-16 Boston Scientific Scimed, Inc. Expandable retrieval device
US8468678B2 (en) 2002-10-02 2013-06-25 Boston Scientific Scimed, Inc. Expandable retrieval device
US7481823B2 (en) * 2002-10-25 2009-01-27 Boston Scientific Scimed, Inc. Multiple membrane embolic protection filter
US20040088000A1 (en) * 2002-10-31 2004-05-06 Muller Paul F. Single-wire expandable cages for embolic filtering devices
US20040102789A1 (en) * 2002-11-22 2004-05-27 Scimed Life Systems, Inc. Selectively locking device
US20040116831A1 (en) * 2002-12-13 2004-06-17 Scimed Life Systems, Inc. Distal protection guidewire with nitinol core
US7625389B2 (en) * 2002-12-30 2009-12-01 Boston Scientific Scimed, Inc. Embolic protection device
US20040138693A1 (en) * 2003-01-14 2004-07-15 Scimed Life Systems, Inc. Snare retrievable embolic protection filter with guidewire stopper
US20040138694A1 (en) * 2003-01-15 2004-07-15 Scimed Life Systems, Inc. Intravascular filtering membrane and method of making an embolic protection filter device
US6984232B2 (en) * 2003-01-17 2006-01-10 St. Jude Medical, Daig Division, Inc. Ablation catheter assembly having a virtual electrode comprising portholes
US6960207B2 (en) * 2003-01-21 2005-11-01 St Jude Medical, Daig Division, Inc. Ablation catheter having a virtual electrode comprising portholes and a porous conductor
US7387629B2 (en) 2003-01-21 2008-06-17 St. Jude Medical, Atrial Fibrillation Division, Inc. Catheter design that facilitates positioning at tissue to be diagnosed or treated
US20040147955A1 (en) * 2003-01-28 2004-07-29 Scimed Life Systems, Inc. Embolic protection filter having an improved filter frame
US7163549B2 (en) * 2003-02-11 2007-01-16 Boston Scientific Scimed Inc. Filter membrane manufacturing method
US20040167566A1 (en) * 2003-02-24 2004-08-26 Scimed Life Systems, Inc. Apparatus for anchoring an intravascular device along a guidewire
US8591540B2 (en) 2003-02-27 2013-11-26 Abbott Cardiovascular Systems Inc. Embolic filtering devices
US20040172055A1 (en) * 2003-02-27 2004-09-02 Huter Scott J. Embolic filtering devices
US7163550B2 (en) * 2003-03-26 2007-01-16 Scimed Life Systems, Inc. Method for manufacturing medical devices from linear elastic materials while maintaining linear elastic properties
US20040193208A1 (en) * 2003-03-27 2004-09-30 Scimed Life Systems, Inc. Radiopaque embolic protection filter membrane
US6960370B2 (en) * 2003-03-27 2005-11-01 Scimed Life Systems, Inc. Methods of forming medical devices
US6939348B2 (en) * 2003-03-27 2005-09-06 Cierra, Inc. Energy based devices and methods for treatment of patent foramen ovale
US20040199201A1 (en) * 2003-04-02 2004-10-07 Scimed Life Systems, Inc. Embolectomy devices
US20040199199A1 (en) * 2003-04-02 2004-10-07 Scimed Life Systems, Inc. Filter and method of making a filter
US6902572B2 (en) * 2003-04-02 2005-06-07 Scimed Life Systems, Inc. Anchoring mechanisms for intravascular devices
US20040204737A1 (en) * 2003-04-11 2004-10-14 Scimed Life Systems, Inc. Embolic filter loop fabricated from composite material
US7780611B2 (en) 2003-05-01 2010-08-24 Boston Scientific Scimed, Inc. Medical instrument with controlled torque transmission
US6969396B2 (en) * 2003-05-07 2005-11-29 Scimed Life Systems, Inc. Filter membrane with increased surface area
US20040249409A1 (en) * 2003-06-09 2004-12-09 Scimed Life Systems, Inc. Reinforced filter membrane
US7537600B2 (en) * 2003-06-12 2009-05-26 Boston Scientific Scimed, Inc. Valved embolic protection filter
US8337519B2 (en) 2003-07-10 2012-12-25 Boston Scientific Scimed, Inc. Embolic protection filtering device
JP2007504910A (en) 2003-09-12 2007-03-08 ミノウ・メディカル・エルエルシイ Selectable biased reshaping and / or excision of atherosclerotic material
US8535344B2 (en) 2003-09-12 2013-09-17 Rubicon Medical, Inc. Methods, systems, and devices for providing embolic protection and removing embolic material
US20050059993A1 (en) * 2003-09-17 2005-03-17 Kamal Ramzipoor Embolectomy device
US7205624B2 (en) * 2003-10-07 2007-04-17 Applied Materials, Inc. Self-aligned implanted waveguide detector
US6994718B2 (en) * 2003-10-29 2006-02-07 Medtronic Vascular, Inc. Distal protection device for filtering and occlusion
US7892251B1 (en) 2003-11-12 2011-02-22 Advanced Cardiovascular Systems, Inc. Component for delivering and locking a medical device to a guide wire
US7056286B2 (en) 2003-11-12 2006-06-06 Adrian Ravenscroft Medical device anchor and delivery system
US7716801B2 (en) * 2003-11-24 2010-05-18 Medtronic Vascular, Inc. Low-profile distal protection device
US7651514B2 (en) 2003-12-11 2010-01-26 Boston Scientific Scimed, Inc. Nose rider improvement for filter exchange and methods of use
US20050137686A1 (en) * 2003-12-23 2005-06-23 Sadra Medical, A Delaware Corporation Externally expandable heart valve anchor and method
US20050267467A1 (en) * 2004-01-16 2005-12-01 Saurav Paul Bipolar conforming electrode catheter and methods for ablation
US20110208233A1 (en) * 2004-01-22 2011-08-25 Mcguckin Jr James F Device for preventing clot migration from left atrial appendage
US8211140B2 (en) * 2004-01-22 2012-07-03 Rex Medical, L.P. Vein filter
US8062326B2 (en) 2004-01-22 2011-11-22 Rex Medical, L.P. Vein filter
US9510929B2 (en) 2004-01-22 2016-12-06 Argon Medical Devices, Inc. Vein filter
US7704266B2 (en) 2004-01-22 2010-04-27 Rex Medical, L.P. Vein filter
US8500774B2 (en) 2004-01-22 2013-08-06 Rex Medical, L.P. Vein filter
US7338512B2 (en) * 2004-01-22 2008-03-04 Rex Medical, L.P. Vein filter
US7976562B2 (en) * 2004-01-22 2011-07-12 Rex Medical, L.P. Method of removing a vein filter
US8162972B2 (en) 2004-01-22 2012-04-24 Rex Medical, Lp Vein filter
CA2553940A1 (en) * 2004-01-30 2005-08-18 Nmt Medical, Inc. Devices, systems, and methods for closure of cardiac openings
US7678129B1 (en) 2004-03-19 2010-03-16 Advanced Cardiovascular Systems, Inc. Locking component for an embolic filter assembly
US20050240215A1 (en) * 2004-04-21 2005-10-27 Scimed Life Systems, Inc. Magnetic embolic protection device and method
US8945116B2 (en) * 2004-05-17 2015-02-03 Boston Scientific Scimed, Inc. Mapping and ablation method for the treatment of ventricular tachycardia
US7367975B2 (en) * 2004-06-21 2008-05-06 Cierra, Inc. Energy based devices and methods for treatment of anatomic tissue defects
US7794472B2 (en) 2004-08-11 2010-09-14 Boston Scientific Scimed, Inc. Single wire intravascular filter
US7566343B2 (en) 2004-09-02 2009-07-28 Boston Scientific Scimed, Inc. Cardiac valve, system, and method
US9713730B2 (en) 2004-09-10 2017-07-25 Boston Scientific Scimed, Inc. Apparatus and method for treatment of in-stent restenosis
US8396548B2 (en) 2008-11-14 2013-03-12 Vessix Vascular, Inc. Selective drug delivery in a lumen
CA2580124C (en) * 2004-09-27 2014-05-13 Rex Medical, L.P. Vein filter
US8795315B2 (en) 2004-10-06 2014-08-05 Cook Medical Technologies Llc Emboli capturing device having a coil and method for capturing emboli
US7621904B2 (en) 2004-10-21 2009-11-24 Boston Scientific Scimed, Inc. Catheter with a pre-shaped distal tip
US20060095067A1 (en) * 2004-11-01 2006-05-04 Horng-Ban Lin Lubricious filter
US8038696B2 (en) * 2004-12-06 2011-10-18 Boston Scientific Scimed, Inc. Sheath for use with an embolic protection filter
CN101076290B (en) 2004-12-09 2011-11-23 铸造品股份有限公司 Aortic valve repair
US7891085B1 (en) * 2005-01-11 2011-02-22 Boston Scientific Neuromodulation Corporation Electrode array assembly and method of making same
US7204464B2 (en) * 2005-01-21 2007-04-17 Boston Scientific Scimed, Inc. Medical wire holder
US8480629B2 (en) 2005-01-28 2013-07-09 Boston Scientific Scimed, Inc. Universal utility board for use with medical devices and methods of use
US20060173490A1 (en) * 2005-02-01 2006-08-03 Boston Scientific Scimed, Inc. Filter system and method
US20080009747A1 (en) * 2005-02-02 2008-01-10 Voyage Medical, Inc. Transmural subsurface interrogation and ablation
US8078266B2 (en) 2005-10-25 2011-12-13 Voyage Medical, Inc. Flow reduction hood systems
US20080015569A1 (en) 2005-02-02 2008-01-17 Voyage Medical, Inc. Methods and apparatus for treatment of atrial fibrillation
US7930016B1 (en) 2005-02-02 2011-04-19 Voyage Medical, Inc. Tissue closure system
US7918787B2 (en) 2005-02-02 2011-04-05 Voyage Medical, Inc. Tissue visualization and manipulation systems
US9510732B2 (en) 2005-10-25 2016-12-06 Intuitive Surgical Operations, Inc. Methods and apparatus for efficient purging
US7860555B2 (en) * 2005-02-02 2010-12-28 Voyage Medical, Inc. Tissue visualization and manipulation system
US11478152B2 (en) 2005-02-02 2022-10-25 Intuitive Surgical Operations, Inc. Electrophysiology mapping and visualization system
US7860556B2 (en) * 2005-02-02 2010-12-28 Voyage Medical, Inc. Tissue imaging and extraction systems
US8137333B2 (en) * 2005-10-25 2012-03-20 Voyage Medical, Inc. Delivery of biological compounds to ischemic and/or infarcted tissue
US10064540B2 (en) 2005-02-02 2018-09-04 Intuitive Surgical Operations, Inc. Visualization apparatus for transseptal access
US8050746B2 (en) 2005-02-02 2011-11-01 Voyage Medical, Inc. Tissue visualization device and method variations
US20060184194A1 (en) * 2005-02-15 2006-08-17 Cook Incorporated Embolic protection device
US8109941B2 (en) * 2005-02-28 2012-02-07 Boston Scientific Scimed, Inc. Distal release retrieval assembly and related methods of use
US7998164B2 (en) * 2005-03-11 2011-08-16 Boston Scientific Scimed, Inc. Intravascular filter with centering member
US8221446B2 (en) 2005-03-15 2012-07-17 Cook Medical Technologies Embolic protection device
US8945169B2 (en) 2005-03-15 2015-02-03 Cook Medical Technologies Llc Embolic protection device
US20060224175A1 (en) * 2005-03-29 2006-10-05 Vrba Anthony C Methods and apparatuses for disposition of a medical device onto an elongate medical device
US9259305B2 (en) 2005-03-31 2016-02-16 Abbott Cardiovascular Systems Inc. Guide wire locking mechanism for rapid exchange and other catheter systems
US7419486B2 (en) * 2005-06-15 2008-09-02 St. Jude Medical, Atrial Fibrillation Division, Inc. Treatment and diagnostic catheters with hydrogel electrodes
US7776034B2 (en) * 2005-06-15 2010-08-17 St. Jude Medical, Atrial Fibrillation Division, Inc. Ablation catheter with adjustable virtual electrode
US8109962B2 (en) 2005-06-20 2012-02-07 Cook Medical Technologies Llc Retrievable device having a reticulation portion with staggered struts
US7850708B2 (en) 2005-06-20 2010-12-14 Cook Incorporated Embolic protection device having a reticulated body with staggered struts
US7819868B2 (en) * 2005-06-21 2010-10-26 St. Jude Medical, Atrial Fibrilation Division, Inc. Ablation catheter with fluid distribution structures
US7766934B2 (en) 2005-07-12 2010-08-03 Cook Incorporated Embolic protection device with an integral basket and bag
US7771452B2 (en) 2005-07-12 2010-08-10 Cook Incorporated Embolic protection device with a filter bag that disengages from a basket
US7879030B2 (en) 2005-07-27 2011-02-01 St. Jude Medical, Atrial Fibrillation Division, Inc. Multipolar, virtual-electrode catheter with at least one surface electrode and method for ablation
US8187298B2 (en) 2005-08-04 2012-05-29 Cook Medical Technologies Llc Embolic protection device having inflatable frame
US7416552B2 (en) 2005-08-22 2008-08-26 St. Jude Medical, Atrial Fibrillation Division, Inc. Multipolar, multi-lumen, virtual-electrode catheter with at least one surface electrode and method for ablation
WO2007030430A1 (en) * 2005-09-06 2007-03-15 Nmt Medical, Inc. Devices and methods for treating cardiac tissue
US9259267B2 (en) 2005-09-06 2016-02-16 W.L. Gore & Associates, Inc. Devices and methods for treating cardiac tissue
US7797056B2 (en) * 2005-09-06 2010-09-14 Nmt Medical, Inc. Removable intracardiac RF device
US8377092B2 (en) 2005-09-16 2013-02-19 Cook Medical Technologies Llc Embolic protection device
US8632562B2 (en) 2005-10-03 2014-01-21 Cook Medical Technologies Llc Embolic protection device
US8182508B2 (en) 2005-10-04 2012-05-22 Cook Medical Technologies Llc Embolic protection device
US20070088382A1 (en) * 2005-10-13 2007-04-19 Bei Nianjiong J Embolic protection recovery catheter assembly
US8252017B2 (en) 2005-10-18 2012-08-28 Cook Medical Technologies Llc Invertible filter for embolic protection
US8221310B2 (en) 2005-10-25 2012-07-17 Voyage Medical, Inc. Tissue visualization device and method variations
US8216269B2 (en) 2005-11-02 2012-07-10 Cook Medical Technologies Llc Embolic protection device having reduced profile
WO2007055783A1 (en) * 2005-11-08 2007-05-18 Nmt Medical, Inc. Conformable electrode catheter and method of use
US8152831B2 (en) 2005-11-17 2012-04-10 Cook Medical Technologies Llc Foam embolic protection device
US9119651B2 (en) 2006-02-13 2015-09-01 Retro Vascular, Inc. Recanalizing occluded vessels using controlled antegrade and retrograde tracking
WO2007095191A2 (en) * 2006-02-13 2007-08-23 Retrovascular, Inc. Recanalizing occluded vessels using controlled antegrade and retrograde tracking
US20070225750A1 (en) * 2006-03-10 2007-09-27 Brooke Ren Embolic protection systems
US8019435B2 (en) 2006-05-02 2011-09-13 Boston Scientific Scimed, Inc. Control of arterial smooth muscle tone
US20070265655A1 (en) * 2006-05-09 2007-11-15 Boston Scientific Scimed, Inc. Embolic protection filter with enhanced stability within a vessel
US7774051B2 (en) * 2006-05-17 2010-08-10 St. Jude Medical, Atrial Fibrillation Division, Inc. System and method for mapping electrophysiology information onto complex geometry
US8480636B2 (en) * 2006-05-17 2013-07-09 St. Jude Medical, Atrial Fibrillation Division, Inc. Catheter with aspiration passageway
US9055906B2 (en) 2006-06-14 2015-06-16 Intuitive Surgical Operations, Inc. In-vivo visualization systems
US8277479B2 (en) * 2006-06-26 2012-10-02 Boston Scientific Scimed, Inc. Self-opening filter with wire actuation
US20080033241A1 (en) * 2006-08-01 2008-02-07 Ruey-Feng Peh Left atrial appendage closure
US10076401B2 (en) 2006-08-29 2018-09-18 Argon Medical Devices, Inc. Vein filter
WO2008028149A2 (en) 2006-09-01 2008-03-06 Voyage Medical, Inc. Electrophysiology mapping and visualization system
US10004388B2 (en) 2006-09-01 2018-06-26 Intuitive Surgical Operations, Inc. Coronary sinus cannulation
US20080097476A1 (en) 2006-09-01 2008-04-24 Voyage Medical, Inc. Precision control systems for tissue visualization and manipulation assemblies
US20080071307A1 (en) 2006-09-19 2008-03-20 Cook Incorporated Apparatus and methods for in situ embolic protection
NZ575465A (en) * 2006-10-04 2011-06-30 Tokyo Electric Power Co Ac-dc conversion device
WO2008049082A2 (en) 2006-10-18 2008-04-24 Minnow Medical, Inc. Inducing desirable temperature effects on body tissue
EP2954868A1 (en) 2006-10-18 2015-12-16 Vessix Vascular, Inc. Tuned rf energy and electrical tissue characterization for selective treatment of target tissues
AU2007310991B2 (en) 2006-10-18 2013-06-20 Boston Scientific Scimed, Inc. System for inducing desirable temperature effects on body tissue
US10335131B2 (en) 2006-10-23 2019-07-02 Intuitive Surgical Operations, Inc. Methods for preventing tissue migration
US20090248143A1 (en) * 2006-10-24 2009-10-01 Beth Israel Deaconess Medical Center Percutaneous aortic valve assembly
US20080183036A1 (en) 2006-12-18 2008-07-31 Voyage Medical, Inc. Systems and methods for unobstructed visualization and ablation
US8131350B2 (en) 2006-12-21 2012-03-06 Voyage Medical, Inc. Stabilization of visualization catheters
US9226648B2 (en) 2006-12-21 2016-01-05 Intuitive Surgical Operations, Inc. Off-axis visualization systems
US8961551B2 (en) 2006-12-22 2015-02-24 The Spectranetics Corporation Retractable separating systems and methods
US9028520B2 (en) 2006-12-22 2015-05-12 The Spectranetics Corporation Tissue separating systems and methods
US9901434B2 (en) 2007-02-27 2018-02-27 Cook Medical Technologies Llc Embolic protection device including a Z-stent waist band
WO2008134457A1 (en) 2007-04-27 2008-11-06 Voyage Medical, Inc. Complex shape steerable tissue visualization and manipulation catheter
US8657805B2 (en) 2007-05-08 2014-02-25 Intuitive Surgical Operations, Inc. Complex shape steerable tissue visualization and manipulation catheter
WO2008141238A1 (en) 2007-05-11 2008-11-20 Voyage Medical, Inc. Visual electrode ablation systems
JP2010532180A (en) * 2007-05-31 2010-10-07 レックス メディカル リミテッド パートナーシップ Fallopian tube occlusion device
AU2008260629A1 (en) * 2007-05-31 2008-12-11 Rex Medical, L.P. Closure device for left atrial appendage
US8216209B2 (en) 2007-05-31 2012-07-10 Abbott Cardiovascular Systems Inc. Method and apparatus for delivering an agent to a kidney
US7867273B2 (en) 2007-06-27 2011-01-11 Abbott Laboratories Endoprostheses for peripheral arteries and other body vessels
US8235985B2 (en) 2007-08-31 2012-08-07 Voyage Medical, Inc. Visualization and ablation system variations
US8252018B2 (en) 2007-09-14 2012-08-28 Cook Medical Technologies Llc Helical embolic protection device
US8419748B2 (en) 2007-09-14 2013-04-16 Cook Medical Technologies Llc Helical thrombus removal device
US9138307B2 (en) 2007-09-14 2015-09-22 Cook Medical Technologies Llc Expandable device for treatment of a stricture in a body vessel
US9283034B2 (en) * 2007-09-26 2016-03-15 Retrovascular, Inc. Recanalization system using radiofrequency energy
CA3024053C (en) * 2007-09-26 2021-12-07 Osamu Katoh Energy delivery and imaging catheter
US9561073B2 (en) 2007-09-26 2017-02-07 Retrovascular, Inc. Energy facilitated composition delivery
US20090143640A1 (en) * 2007-11-26 2009-06-04 Voyage Medical, Inc. Combination imaging and treatment assemblies
US8460181B2 (en) * 2008-01-17 2013-06-11 Nidus Medical, Llc Epicardial access and treatment systems
US8858609B2 (en) 2008-02-07 2014-10-14 Intuitive Surgical Operations, Inc. Stent delivery under direct visualization
US20090326572A1 (en) * 2008-06-27 2009-12-31 Ruey-Feng Peh Apparatus and methods for rapid tissue crossing
US9101735B2 (en) 2008-07-07 2015-08-11 Intuitive Surgical Operations, Inc. Catheter control systems
DE202009019019U1 (en) 2008-09-04 2015-07-27 Swat Medical Ab Foldable temporary embolic protection device with elongated blood permeable unit
US8333012B2 (en) * 2008-10-10 2012-12-18 Voyage Medical, Inc. Method of forming electrode placement and connection systems
US8894643B2 (en) 2008-10-10 2014-11-25 Intuitive Surgical Operations, Inc. Integral electrode placement and connection systems
US9468364B2 (en) 2008-11-14 2016-10-18 Intuitive Surgical Operations, Inc. Intravascular catheter with hood and image processing systems
CN102271603A (en) 2008-11-17 2011-12-07 明诺医学股份有限公司 Selective accumulation of energy with or without knowledge of tissue topography
US8444669B2 (en) 2008-12-15 2013-05-21 Boston Scientific Scimed, Inc. Embolic filter delivery system and method
US8992558B2 (en) 2008-12-18 2015-03-31 Osteomed, Llc Lateral access system for the lumbar spine
US20100160947A1 (en) * 2008-12-18 2010-06-24 IMDS, Inc. Systems and methods for dilation and dissection of tissues
US8388644B2 (en) 2008-12-29 2013-03-05 Cook Medical Technologies Llc Embolic protection device and method of use
US20100204561A1 (en) * 2009-02-11 2010-08-12 Voyage Medical, Inc. Imaging catheters having irrigation
US20100256629A1 (en) * 2009-04-06 2010-10-07 Voyage Medical, Inc. Methods and devices for treatment of the ostium
US8832684B2 (en) * 2009-06-18 2014-09-09 The Johns Hopkins University Methods for improving atomicity of runtime inspections
US10092427B2 (en) 2009-11-04 2018-10-09 Confluent Medical Technologies, Inc. Alternating circumferential bridge stent design and methods for use thereof
US9649211B2 (en) 2009-11-04 2017-05-16 Confluent Medical Technologies, Inc. Alternating circumferential bridge stent design and methods for use thereof
US8696698B2 (en) * 2009-12-02 2014-04-15 Surefire Medical, Inc. Microvalve protection device and method of use for protection against embolization agent reflux
US8500775B2 (en) * 2009-12-02 2013-08-06 Surefire Medical, Inc. Protection device and method against embolization agent reflux
US9539081B2 (en) 2009-12-02 2017-01-10 Surefire Medical, Inc. Method of operating a microvalve protection device
US8694071B2 (en) 2010-02-12 2014-04-08 Intuitive Surgical Operations, Inc. Image stabilization techniques and methods
US8728067B2 (en) * 2010-03-08 2014-05-20 Covidien Lp Microwave antenna probe having a deployable ground plane
US9814522B2 (en) 2010-04-06 2017-11-14 Intuitive Surgical Operations, Inc. Apparatus and methods for ablation efficacy
EP2555699B1 (en) 2010-04-09 2019-04-03 Vessix Vascular, Inc. Power generating and control apparatus for the treatment of tissue
US9192790B2 (en) 2010-04-14 2015-11-24 Boston Scientific Scimed, Inc. Focused ultrasonic renal denervation
US8728162B2 (en) 2010-04-15 2014-05-20 Osteomed, Llc Direct lateral spine system instruments, implants and associated methods
US8473067B2 (en) 2010-06-11 2013-06-25 Boston Scientific Scimed, Inc. Renal denervation and stimulation employing wireless vascular energy transfer arrangement
US9463062B2 (en) 2010-07-30 2016-10-11 Boston Scientific Scimed, Inc. Cooled conductive balloon RF catheter for renal nerve ablation
US9408661B2 (en) 2010-07-30 2016-08-09 Patrick A. Haverkost RF electrodes on multiple flexible wires for renal nerve ablation
US9084609B2 (en) 2010-07-30 2015-07-21 Boston Scientific Scime, Inc. Spiral balloon catheter for renal nerve ablation
US9358365B2 (en) 2010-07-30 2016-06-07 Boston Scientific Scimed, Inc. Precision electrode movement control for renal nerve ablation
US9155589B2 (en) 2010-07-30 2015-10-13 Boston Scientific Scimed, Inc. Sequential activation RF electrode set for renal nerve ablation
US8974451B2 (en) 2010-10-25 2015-03-10 Boston Scientific Scimed, Inc. Renal nerve ablation using conductive fluid jet and RF energy
US9220558B2 (en) 2010-10-27 2015-12-29 Boston Scientific Scimed, Inc. RF renal denervation catheter with multiple independent electrodes
US9028485B2 (en) 2010-11-15 2015-05-12 Boston Scientific Scimed, Inc. Self-expanding cooling electrode for renal nerve ablation
US9668811B2 (en) 2010-11-16 2017-06-06 Boston Scientific Scimed, Inc. Minimally invasive access for renal nerve ablation
US9089350B2 (en) 2010-11-16 2015-07-28 Boston Scientific Scimed, Inc. Renal denervation catheter with RF electrode and integral contrast dye injection arrangement
US9326751B2 (en) 2010-11-17 2016-05-03 Boston Scientific Scimed, Inc. Catheter guidance of external energy for renal denervation
US9060761B2 (en) 2010-11-18 2015-06-23 Boston Scientific Scime, Inc. Catheter-focused magnetic field induced renal nerve ablation
US9192435B2 (en) 2010-11-22 2015-11-24 Boston Scientific Scimed, Inc. Renal denervation catheter with cooled RF electrode
US9023034B2 (en) 2010-11-22 2015-05-05 Boston Scientific Scimed, Inc. Renal ablation electrode with force-activatable conduction apparatus
US9770319B2 (en) 2010-12-01 2017-09-26 Surefire Medical, Inc. Closed tip dynamic microvalve protection device
US20120157993A1 (en) 2010-12-15 2012-06-21 Jenson Mark L Bipolar Off-Wall Electrode Device for Renal Nerve Ablation
WO2012097287A1 (en) * 2011-01-13 2012-07-19 Innovia Llc Endoluminal drug applicator and method of treating diseased vessels of the body
US9220561B2 (en) 2011-01-19 2015-12-29 Boston Scientific Scimed, Inc. Guide-compatible large-electrode catheter for renal nerve ablation with reduced arterial injury
US20120221042A1 (en) * 2011-01-28 2012-08-30 Tricardia, Llc Methods And Devices For Treating The Left Atrial Appendage
WO2012127309A1 (en) 2011-03-21 2012-09-27 Ontorfano Matteo Disk-based valve apparatus and method for the treatment of valve dysfunction
US20120271340A1 (en) * 2011-04-25 2012-10-25 Medtronic, Inc. Method and Apparatus for Embolic Protection During Heart Procedure
US20120271341A1 (en) * 2011-04-25 2012-10-25 Hill Alexander J Method and Apparatus for Treating a Mitral Valve Prolapse and Providing Embolic Protection
US9198706B2 (en) 2011-05-12 2015-12-01 Cvdevices, Llc Systems and methods for cryoblation of a tissue
AU2012283908B2 (en) 2011-07-20 2017-02-16 Boston Scientific Scimed, Inc. Percutaneous devices and methods to visualize, target and ablate nerves
AU2012287189B2 (en) 2011-07-22 2016-10-06 Boston Scientific Scimed, Inc. Nerve modulation system with a nerve modulation element positionable in a helical guide
US9089668B2 (en) 2011-09-28 2015-07-28 Surefire Medical, Inc. Flow directional infusion device
US9186210B2 (en) 2011-10-10 2015-11-17 Boston Scientific Scimed, Inc. Medical devices including ablation electrodes
WO2013055815A1 (en) 2011-10-11 2013-04-18 Boston Scientific Scimed, Inc. Off -wall electrode device for nerve modulation
US9420955B2 (en) 2011-10-11 2016-08-23 Boston Scientific Scimed, Inc. Intravascular temperature monitoring system and method
US9364284B2 (en) 2011-10-12 2016-06-14 Boston Scientific Scimed, Inc. Method of making an off-wall spacer cage
EP2768568B1 (en) 2011-10-18 2020-05-06 Boston Scientific Scimed, Inc. Integrated crossing balloon catheter
EP2768563B1 (en) 2011-10-18 2016-11-09 Boston Scientific Scimed, Inc. Deflectable medical devices
CN104023662B (en) 2011-11-08 2018-02-09 波士顿科学西美德公司 Hole portion renal nerve melts
US9119600B2 (en) 2011-11-15 2015-09-01 Boston Scientific Scimed, Inc. Device and methods for renal nerve modulation monitoring
US9119632B2 (en) 2011-11-21 2015-09-01 Boston Scientific Scimed, Inc. Deflectable renal nerve ablation catheter
US9265969B2 (en) 2011-12-21 2016-02-23 Cardiac Pacemakers, Inc. Methods for modulating cell function
EP3138521B1 (en) 2011-12-23 2019-05-29 Vessix Vascular, Inc. Apparatuses for remodeling tissue of or adjacent to a body passage
US9433760B2 (en) 2011-12-28 2016-09-06 Boston Scientific Scimed, Inc. Device and methods for nerve modulation using a novel ablation catheter with polymeric ablative elements
US9050106B2 (en) 2011-12-29 2015-06-09 Boston Scientific Scimed, Inc. Off-wall electrode device and methods for nerve modulation
US9089341B2 (en) 2012-02-28 2015-07-28 Surefire Medical, Inc. Renal nerve neuromodulation device
WO2013169927A1 (en) 2012-05-08 2013-11-14 Boston Scientific Scimed, Inc. Renal nerve modulation devices
WO2014032016A1 (en) 2012-08-24 2014-02-27 Boston Scientific Scimed, Inc. Intravascular catheter with a balloon comprising separate microporous regions
US9949753B2 (en) 2012-09-14 2018-04-24 The Spectranetics Corporation Tissue slitting methods and systems
CN104780859B (en) 2012-09-17 2017-07-25 波士顿科学西美德公司 Self-positioning electrode system and method for renal regulation
WO2014047411A1 (en) 2012-09-21 2014-03-27 Boston Scientific Scimed, Inc. System for nerve modulation and innocuous thermal gradient nerve block
WO2014047454A2 (en) 2012-09-21 2014-03-27 Boston Scientific Scimed, Inc. Self-cooling ultrasound ablation catheter
US10835305B2 (en) 2012-10-10 2020-11-17 Boston Scientific Scimed, Inc. Renal nerve modulation devices and methods
CN104812322B (en) 2012-12-20 2018-12-11 雷纳尔动力有限公司 Multiple spot treats probe and its application method
US9693821B2 (en) 2013-03-11 2017-07-04 Boston Scientific Scimed, Inc. Medical devices for modulating nerves
WO2014163987A1 (en) 2013-03-11 2014-10-09 Boston Scientific Scimed, Inc. Medical devices for modulating nerves
US9283040B2 (en) 2013-03-13 2016-03-15 The Spectranetics Corporation Device and method of ablative cutting with helical tip
US9291663B2 (en) 2013-03-13 2016-03-22 The Spectranetics Corporation Alarm for lead insulation abnormality
US9808311B2 (en) 2013-03-13 2017-11-07 Boston Scientific Scimed, Inc. Deflectable medical devices
US9883885B2 (en) 2013-03-13 2018-02-06 The Spectranetics Corporation System and method of ablative cutting and pulsed vacuum aspiration
US10383691B2 (en) 2013-03-13 2019-08-20 The Spectranetics Corporation Last catheter with helical internal lumen
US9456872B2 (en) 2013-03-13 2016-10-04 The Spectranetics Corporation Laser ablation catheter
US10835279B2 (en) 2013-03-14 2020-11-17 Spectranetics Llc Distal end supported tissue slitting apparatus
US10842532B2 (en) 2013-03-15 2020-11-24 Spectranetics Llc Medical device for removing an implanted object
US9668765B2 (en) 2013-03-15 2017-06-06 The Spectranetics Corporation Retractable blade for lead removal device
US9918737B2 (en) 2013-03-15 2018-03-20 The Spectranetics Corporation Medical device for removing an implanted object
JP6220044B2 (en) 2013-03-15 2017-10-25 ボストン サイエンティフィック サイムド,インコーポレイテッドBoston Scientific Scimed,Inc. Medical device for renal nerve ablation
WO2017048486A1 (en) 2013-03-15 2017-03-23 The Spectranetics Corporation Medical device for removing an implanted object using laser cut hypotubes
US9925366B2 (en) 2013-03-15 2018-03-27 The Spectranetics Corporation Surgical instrument for removing an implanted object
US10265122B2 (en) 2013-03-15 2019-04-23 Boston Scientific Scimed, Inc. Nerve ablation devices and related methods of use
US10136913B2 (en) 2013-03-15 2018-11-27 The Spectranetics Corporation Multiple configuration surgical cutting device
AU2014237950B2 (en) 2013-03-15 2017-04-13 Boston Scientific Scimed, Inc. Control unit for use with electrode pads and a method for estimating an electrical leakage
US10448999B2 (en) 2013-03-15 2019-10-22 The Spectranetics Corporation Surgical instrument for removing an implanted object
US10342565B2 (en) * 2013-04-24 2019-07-09 Hologic, Inc. Surgical system with expandable shield
WO2014205388A1 (en) 2013-06-21 2014-12-24 Boston Scientific Scimed, Inc. Renal denervation balloon catheter with ride along electrode support
WO2014205399A1 (en) 2013-06-21 2014-12-24 Boston Scientific Scimed, Inc. Medical devices for renal nerve ablation having rotatable shafts
US9707036B2 (en) 2013-06-25 2017-07-18 Boston Scientific Scimed, Inc. Devices and methods for nerve modulation using localized indifferent electrodes
EP3016605B1 (en) 2013-07-01 2019-06-05 Boston Scientific Scimed, Inc. Medical devices for renal nerve ablation
CN105377170A (en) 2013-07-11 2016-03-02 波士顿科学国际有限公司 Medical device with stretchable electrode assemblies
US10660698B2 (en) 2013-07-11 2020-05-26 Boston Scientific Scimed, Inc. Devices and methods for nerve modulation
US8870948B1 (en) 2013-07-17 2014-10-28 Cephea Valve Technologies, Inc. System and method for cardiac valve repair and replacement
CN105682594B (en) 2013-07-19 2018-06-22 波士顿科学国际有限公司 Helical bipolar electrodes renal denervation dominates air bag
WO2015013301A1 (en) 2013-07-22 2015-01-29 Boston Scientific Scimed, Inc. Renal nerve ablation catheter having twist balloon
WO2015013205A1 (en) 2013-07-22 2015-01-29 Boston Scientific Scimed, Inc. Medical devices for renal nerve ablation
EP4049605A1 (en) 2013-08-22 2022-08-31 Boston Scientific Scimed Inc. Flexible circuit having improved adhesion to a renal nerve modulation balloon
CN105555218B (en) 2013-09-04 2019-01-15 波士顿科学国际有限公司 With radio frequency (RF) foley's tube rinsed with cooling capacity
CN105530885B (en) 2013-09-13 2020-09-22 波士顿科学国际有限公司 Ablation balloon with vapor deposited covering
US9687166B2 (en) 2013-10-14 2017-06-27 Boston Scientific Scimed, Inc. High resolution cardiac mapping electrode array catheter
US11246654B2 (en) 2013-10-14 2022-02-15 Boston Scientific Scimed, Inc. Flexible renal nerve ablation devices and related methods of use and manufacture
CN105636537B (en) 2013-10-15 2018-08-17 波士顿科学国际有限公司 Medical instrument sacculus
US9770606B2 (en) 2013-10-15 2017-09-26 Boston Scientific Scimed, Inc. Ultrasound ablation catheter with cooling infusion and centering basket
EP3057521B1 (en) 2013-10-18 2020-03-25 Boston Scientific Scimed, Inc. Balloon catheters with flexible conducting wires
US10271898B2 (en) 2013-10-25 2019-04-30 Boston Scientific Scimed, Inc. Embedded thermocouple in denervation flex circuit
CN105899157B (en) 2014-01-06 2019-08-09 波士顿科学国际有限公司 Tear-proof flexible circuit assembly
US11000679B2 (en) 2014-02-04 2021-05-11 Boston Scientific Scimed, Inc. Balloon protection and rewrapping devices and related methods of use
CN106572881B (en) 2014-02-04 2019-07-26 波士顿科学国际有限公司 Substitution of the heat sensor on bipolar electrode is placed
US9579149B2 (en) 2014-03-13 2017-02-28 Medtronic Ardian Luxembourg S.A.R.L. Low profile catheter assemblies and associated systems and methods
US9968740B2 (en) 2014-03-25 2018-05-15 Surefire Medical, Inc. Closed tip dynamic microvalve protection device
US9889031B1 (en) 2014-03-25 2018-02-13 Surefire Medical, Inc. Method of gastric artery embolization
US10405924B2 (en) 2014-05-30 2019-09-10 The Spectranetics Corporation System and method of ablative cutting and vacuum aspiration through primary orifice and auxiliary side port
US10729454B2 (en) 2014-09-10 2020-08-04 Teleflex Life Sciences Limited Guidewire capture
WO2016093877A1 (en) 2014-12-09 2016-06-16 Cephea Valve Technologies, Inc. Replacement cardiac valves and methods of use and manufacture
JP2018500395A (en) * 2014-12-15 2018-01-11 ノースイースタン・ユニバーシティ Collagen tissue treatment device
USD765243S1 (en) 2015-02-20 2016-08-30 The Spectranetics Corporation Medical device handle
USD770616S1 (en) 2015-02-20 2016-11-01 The Spectranetics Corporation Medical device handle
US20160287839A1 (en) 2015-03-31 2016-10-06 Surefire Medical, Inc. Apparatus and Method for Infusing an Immunotherapy Agent to a Solid Tumor for Treatment
EP4335415A2 (en) 2015-05-14 2024-03-13 Cephea Valve Technologies, Inc. Replacement mitral valves
WO2016183523A1 (en) 2015-05-14 2016-11-17 Cephea Valve Technologies, Inc. Cardiac valve delivery devices and systems
US11331187B2 (en) 2016-06-17 2022-05-17 Cephea Valve Technologies, Inc. Cardiac valve delivery devices and systems
EP3503814A1 (en) 2016-08-23 2019-07-03 Stryker European Holdings I, LLC Instrumentation for the implantation of spinal implants
US11877752B2 (en) * 2016-09-07 2024-01-23 Daniel Ezra Walzman Filterless aspiration, irrigating, macerating, rotating microcatheter and method of use
US11439492B2 (en) 2016-09-07 2022-09-13 Daniel Ezra Walzman Lasso filter tipped microcatheter for simultaneous rotating separator, irrigator for thrombectomy and method for use
US10314684B2 (en) * 2016-09-07 2019-06-11 Daniel Ezra Walzman Simultaneous rotating separator, irrigator microcatheter for thrombectomy
US11259820B2 (en) * 2016-09-07 2022-03-01 Daniel Ezra Walzman Methods and devices to ameliorate vascular obstruction
US10780250B1 (en) 2016-09-19 2020-09-22 Surefire Medical, Inc. System and method for selective pressure-controlled therapeutic delivery
US11400263B1 (en) 2016-09-19 2022-08-02 Trisalus Life Sciences, Inc. System and method for selective pressure-controlled therapeutic delivery
US10245050B2 (en) 2016-09-30 2019-04-02 Teleflex Innovations S.À.R.L. Methods for facilitating revascularization of occlusion
WO2018098210A1 (en) * 2016-11-22 2018-05-31 Synecor Llc Guidewireless transseptal delivery system for therapeutic devices of the mitral valve
US10806893B2 (en) 2017-01-10 2020-10-20 Surefire Medical, Inc. Guiding catheter having shape-retentive distal end
CA3051272C (en) 2017-01-23 2023-08-22 Cephea Valve Technologies, Inc. Replacement mitral valves
EP4209196A1 (en) 2017-01-23 2023-07-12 Cephea Valve Technologies, Inc. Replacement mitral valves
WO2018138658A1 (en) 2017-01-27 2018-08-02 Jenavalve Technology, Inc. Heart valve mimicry
US10588636B2 (en) 2017-03-20 2020-03-17 Surefire Medical, Inc. Dynamic reconfigurable microvalve protection device
WO2019055154A2 (en) * 2017-08-06 2019-03-21 Synecor Llc Systems and methods for transseptal delivery of therapeutic devices of the heart
EP3545857B1 (en) 2018-03-30 2024-01-03 Stryker European Operations Holdings LLC Lateral access retractor and core insertion
US11850398B2 (en) 2018-08-01 2023-12-26 Trisalus Life Sciences, Inc. Systems and methods for pressure-facilitated therapeutic agent delivery
US20200069913A1 (en) * 2018-09-05 2020-03-05 Boston Scientific Scimed, Inc. Aorto ostial fluid directing device
US11338117B2 (en) 2018-10-08 2022-05-24 Trisalus Life Sciences, Inc. Implantable dual pathway therapeutic agent delivery port
US11135421B2 (en) 2019-02-07 2021-10-05 Synecor Llc Conduit for transseptal passage of devices to the aorta
US11564674B2 (en) 2019-11-27 2023-01-31 K2M, Inc. Lateral access system and method of use

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0472368A2 (en) * 1990-08-21 1992-02-26 Med Institute, Inc. Ablation catheter
US5662671A (en) 1996-07-17 1997-09-02 Embol-X, Inc. Atherectomy device having trapping and excising means for removal of plaque from the aorta and other arteries
US5769816A (en) 1995-11-07 1998-06-23 Embol-X, Inc. Cannula with associated filter
US5827324A (en) * 1997-03-06 1998-10-27 Scimed Life Systems, Inc. Distal protection device
US5846260A (en) 1997-05-08 1998-12-08 Embol-X, Inc. Cannula with a modular filter for filtering embolic material
US5911734A (en) 1997-05-08 1999-06-15 Embol-X, Inc. Percutaneous catheter and guidewire having filter and medical device deployment capabilities

Family Cites Families (224)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3472230A (en) 1966-12-19 1969-10-14 Fogarty T J Umbrella catheter
US3592186A (en) 1969-01-28 1971-07-13 Claude Oster Cytologic scraper
US3683904A (en) 1970-10-05 1972-08-15 Howard B Forster Pessaries
US3889657A (en) 1974-02-12 1975-06-17 Gomco Surgical Mfg Co Uterine aspirating curette
US3952747A (en) 1974-03-28 1976-04-27 Kimmell Jr Garman O Filter and filter insertion instrument
US3996938A (en) 1975-07-10 1976-12-14 Clark Iii William T Expanding mesh catheter
US4046150A (en) 1975-07-17 1977-09-06 American Hospital Supply Corporation Medical instrument for locating and removing occlusive objects
SU764684A1 (en) 1978-01-31 1980-09-25 Челябинский государственный медицинский институт Trap filter
DE2821048C2 (en) 1978-05-13 1980-07-17 Willy Ruesch Gmbh & Co Kg, 7053 Kernen Medical instrument
US4425908A (en) 1981-10-22 1984-01-17 Beth Israel Hospital Blood clot filter
US4447227A (en) 1982-06-09 1984-05-08 Endoscopy Surgical Systems, Inc. Multi-purpose medical devices
US4643184A (en) 1982-09-29 1987-02-17 Mobin Uddin Kazi Embolus trap
US5190546A (en) 1983-10-14 1993-03-02 Raychem Corporation Medical devices incorporating SIM alloy elements
US5104399A (en) 1986-12-10 1992-04-14 Endovascular Technologies, Inc. Artificial graft and implantation method
US4631052A (en) 1984-01-03 1986-12-23 Intravascular Surgical Instruments, Inc. Method and apparatus for surgically removing remote deposits
US4590938A (en) 1984-05-04 1986-05-27 Segura Joseph W Medical retriever device
DE3417738C2 (en) 1984-05-12 1986-10-02 Ing. Walter Hengst GmbH & Co KG, 4400 Münster Blood filter that can be used in veins
US4957482A (en) 1988-12-19 1990-09-18 Surgical Systems & Instruments, Inc. Atherectomy device with a positive pump means
US5135531A (en) 1984-05-14 1992-08-04 Surgical Systems & Instruments, Inc. Guided atherectomy system
US4842579B1 (en) 1984-05-14 1995-10-31 Surgical Systems & Instr Inc Atherectomy device
US5007896A (en) 1988-12-19 1991-04-16 Surgical Systems & Instruments, Inc. Rotary-catheter for atherectomy
DK151404C (en) 1984-05-23 1988-07-18 Cook Europ Aps William FULLY FILTER FOR IMPLANTATION IN A PATIENT'S BLOOD
US4979951A (en) 1984-05-30 1990-12-25 Simpson John B Atherectomy device and method
US4926858A (en) 1984-05-30 1990-05-22 Devices For Vascular Intervention, Inc. Atherectomy device for severe occlusions
US4580568A (en) 1984-10-01 1986-04-08 Cook, Incorporated Percutaneous endovascular stent and method for insertion thereof
US4790813A (en) 1984-12-17 1988-12-13 Intravascular Surgical Instruments, Inc. Method and apparatus for surgically removing remote deposits
US4807626A (en) 1985-02-14 1989-02-28 Mcgirr Douglas B Stone extractor and method
IT8535720V0 (en) 1985-03-27 1985-03-27 Ital Idee Srl AIR INTAKE FILTER CLOGGING INDICATOR, IN PARTICULAR FOR MOTOR VEHICLE ENGINES
FR2580504B1 (en) 1985-04-22 1987-07-10 Pieronne Alain FILTER FOR THE PARTIAL AND AT LEAST PROVISIONAL INTERRUPTION OF A VEIN AND CATHETER CARRYING THE FILTER
US4706671A (en) 1985-05-02 1987-11-17 Weinrib Harry P Catheter with coiled tip
US4662885A (en) 1985-09-03 1987-05-05 Becton, Dickinson And Company Percutaneously deliverable intravascular filter prosthesis
US4705517A (en) 1985-09-03 1987-11-10 Becton, Dickinson And Company Percutaneously deliverable intravascular occlusion prosthesis
US4641649A (en) * 1985-10-30 1987-02-10 Rca Corporation Method and apparatus for high frequency catheter ablation
US4650466A (en) 1985-11-01 1987-03-17 Angiobrade Partners Angioplasty device
US4733665C2 (en) 1985-11-07 2002-01-29 Expandable Grafts Partnership Expandable intraluminal graft and method and apparatus for implanting an expandable intraluminal graft
US4790812A (en) 1985-11-15 1988-12-13 Hawkins Jr Irvin F Apparatus and method for removing a target object from a body passsageway
USRE33569E (en) 1986-02-28 1991-04-09 Devices For Vascular Intervention, Inc. Single lumen atherectomy catheter device
US4794931A (en) 1986-02-28 1989-01-03 Cardiovascular Imaging Systems, Inc. Catheter apparatus, system and method for intravascular two-dimensional ultrasonography
US4728319A (en) 1986-03-20 1988-03-01 Helmut Masch Intravascular catheter
US4723549A (en) 1986-09-18 1988-02-09 Wholey Mark H Method and apparatus for dilating blood vessels
JPS63158064A (en) 1986-12-23 1988-07-01 テルモ株式会社 Blood vessel dilating catheter
US5041126A (en) 1987-03-13 1991-08-20 Cook Incorporated Endovascular stent and delivery system
US4907336A (en) 1987-03-13 1990-03-13 Cook Incorporated Method of making an endovascular stent and delivery system
US4800882A (en) 1987-03-13 1989-01-31 Cook Incorporated Endovascular stent and delivery system
JPS63238872A (en) 1987-03-25 1988-10-04 テルモ株式会社 Instrument for securing inner diameter of cavity of tubular organ and catheter equipped therewith
US4857045A (en) 1987-04-30 1989-08-15 Schneider (Usa) Inc., A Pfizer Company Atherectomy catheter
US4817600A (en) 1987-05-22 1989-04-04 Medi-Tech, Inc. Implantable filter
US4794928A (en) 1987-06-10 1989-01-03 Kletschka Harold D Angioplasty device and method of using the same
US5059211A (en) 1987-06-25 1991-10-22 Duke University Absorbable vascular stent
US4867157A (en) 1987-08-13 1989-09-19 Baxter Travenol Laboratories, Inc. Surgical cutting instrument
US4898575A (en) 1987-08-31 1990-02-06 Medinnovations, Inc. Guide wire following tunneling catheter system and method for transluminal arterial atherectomy
US4857046A (en) 1987-10-21 1989-08-15 Cordis Corporation Drive catheter having helical pump drive shaft
US4873978A (en) 1987-12-04 1989-10-17 Robert Ginsburg Device and method for emboli retrieval
FR2624747A1 (en) 1987-12-18 1989-06-23 Delsanti Gerard REMOVABLE ENDO-ARTERIAL DEVICES FOR REPAIRING ARTERIAL WALL DECOLLEMENTS
US5053044A (en) 1988-01-11 1991-10-01 Devices For Vascular Intervention, Inc. Catheter and method for making intravascular incisions
US4886061A (en) * 1988-02-09 1989-12-12 Medinnovations, Inc. Expandable pullback atherectomy catheter system
US4921478A (en) 1988-02-23 1990-05-01 C. R. Bard, Inc. Cerebral balloon angioplasty system
EP0415997A4 (en) * 1988-05-18 1992-04-08 Kasevich Associates, Inc. Microwave balloon angioplasty
US4921484A (en) 1988-07-25 1990-05-01 Cordis Corporation Mesh balloon catheter device
US5071425A (en) 1988-09-12 1991-12-10 Devices For Vascular Intervention, Inc. Atherectomy catheter and method of forming the same
US5011488A (en) 1988-12-07 1991-04-30 Robert Ginsburg Thrombus extraction system
US4950277A (en) 1989-01-23 1990-08-21 Interventional Technologies, Inc. Atherectomy cutting device with eccentric wire and method
US4986807A (en) 1989-01-23 1991-01-22 Interventional Technologies, Inc. Atherectomy cutter with radially projecting blade
US5152777A (en) 1989-01-25 1992-10-06 Uresil Corporation Device and method for providing protection from emboli and preventing occulsion of blood vessels
US5087265A (en) 1989-02-17 1992-02-11 American Biomed, Inc. Distal atherectomy catheter
FR2643250B1 (en) 1989-02-20 1997-12-26 Lg Medical Sa INTERVENTION DEVICE ON THE CARDIOVASCULAR SYSTEM ALLOWING IN PARTICULAR THE TREATMENT OF THROMBUS
US4969891A (en) 1989-03-06 1990-11-13 Gewertz Bruce L Removable vascular filter
US5622188A (en) 1989-08-18 1997-04-22 Endovascular Instruments, Inc. Method of restoring reduced or absent blood flow capacity in an artery
DE8910603U1 (en) 1989-09-06 1989-12-07 Guenther, Rolf W., Prof. Dr.
US5002560A (en) 1989-09-08 1991-03-26 Advanced Cardiovascular Systems, Inc. Expandable cage catheter with a rotatable guide
DE8910856U1 (en) 1989-09-12 1989-11-30 Schneider (Europe) Ag, Zuerich, Ch
US5100425A (en) 1989-09-14 1992-03-31 Medintec R&D Limited Partnership Expandable transluminal atherectomy catheter system and method for the treatment of arterial stenoses
DE4030998C2 (en) 1989-10-04 1995-11-23 Ernst Peter Prof Dr M Strecker Percutaneous vascular filter
AU6376190A (en) 1989-10-25 1991-05-02 C.R. Bard Inc. Occluding catheter and methods for treating cerebral arteries
US5019088A (en) 1989-11-07 1991-05-28 Interventional Technologies Inc. Ovoid atherectomy cutter
US5085662A (en) 1989-11-13 1992-02-04 Scimed Life Systems, Inc. Atherectomy catheter and related components
US5195955A (en) 1989-11-14 1993-03-23 Don Michael T Anthony Device for removal of embolic debris
GB2238485B (en) 1989-11-28 1993-07-14 Cook William Europ A collapsible filter for introduction in a blood vessel of a patient
US5421832A (en) 1989-12-13 1995-06-06 Lefebvre; Jean-Marie Filter-catheter and method of manufacturing same
FR2655533A1 (en) 1989-12-13 1991-06-14 Lefebvre Jean Marie FILTER CATHETER.
US5007917A (en) 1990-03-08 1991-04-16 Stryker Corporation Single blade cutter for arthroscopic surgery
US5071407A (en) 1990-04-12 1991-12-10 Schneider (U.S.A.) Inc. Radially expandable fixation member
US5171233A (en) 1990-04-25 1992-12-15 Microvena Corporation Snare-type probe
US5100424A (en) 1990-05-21 1992-03-31 Cardiovascular Imaging Systems, Inc. Intravascular catheter having combined imaging abrasion head
CA2048307C (en) 1990-08-14 1998-08-18 Rolf Gunther Method and apparatus for filtering blood in a blood vessel of a patient
US5160342A (en) 1990-08-16 1992-11-03 Evi Corp. Endovascular filter and method for use thereof
DE4025825A1 (en) 1990-08-16 1992-02-20 Cook William Europ DEVICE FOR CRUSHING BLOOD CLOTS
US5108419A (en) 1990-08-16 1992-04-28 Evi Corporation Endovascular filter and method for use thereof
FR2666980B1 (en) 1990-09-26 1993-07-23 Lg Medical BLOOD FILTRATION UNIT AND DEVICE FOR INTRODUCING SUCH A UNIT ONTO THE BLOOD PATH.
US5449372A (en) 1990-10-09 1995-09-12 Scimed Lifesystems, Inc. Temporary stent and methods for use and manufacture
DE69116130T2 (en) 1990-10-18 1996-05-15 Ho Young Song SELF-EXPANDING, ENDOVASCULAR DILATATOR
US5053008A (en) 1990-11-21 1991-10-01 Sandeep Bajaj Intracardiac catheter
US5152771A (en) 1990-12-31 1992-10-06 The Board Of Supervisors Of Louisiana State University Valve cutter for arterial by-pass surgery
US5356423A (en) 1991-01-04 1994-10-18 American Medical Systems, Inc. Resectable self-expanding stent
CA2075973A1 (en) 1991-02-19 1992-08-20 Robert E. Fischell Apparatus and method for atherectomy
US5350398A (en) 1991-05-13 1994-09-27 Dusan Pavcnik Self-expanding filter for percutaneous insertion
US5569275A (en) 1991-06-11 1996-10-29 Microvena Corporation Mechanical thrombus maceration device
US5314472A (en) 1991-10-01 1994-05-24 Cook Incorporated Vascular stent
US5527354A (en) 1991-06-28 1996-06-18 Cook Incorporated Stent formed of half-round wire
US5415630A (en) 1991-07-17 1995-05-16 Gory; Pierre Method for removably implanting a blood filter in a vein of the human body
DE9109006U1 (en) 1991-07-22 1991-10-10 Schmitz-Rode, Thomas, Dipl.-Ing. Dr.Med., 5100 Aachen, De
US5192286A (en) * 1991-07-26 1993-03-09 Regents Of The University Of California Method and device for retrieving materials from body lumens
US5443498A (en) 1991-10-01 1995-08-22 Cook Incorporated Vascular stent and method of making and implanting a vacsular stent
US5387235A (en) 1991-10-25 1995-02-07 Cook Incorporated Expandable transluminal graft prosthesis for repair of aneurysm
FR2683449A1 (en) 1991-11-08 1993-05-14 Cardon Alain ENDOPROTHESIS FOR TRANSLUMINAL IMPLANTATION.
US5395349A (en) 1991-12-13 1995-03-07 Endovascular Technologies, Inc. Dual valve reinforced sheath and method
FR2685190B1 (en) 1991-12-23 1998-08-07 Jean Marie Lefebvre ROTARY ATHERECTOMY OR THROMBECTOMY DEVICE WITH CENTRIFUGAL TRANSVERSE DEVELOPMENT.
US5626605A (en) 1991-12-30 1997-05-06 Scimed Life Systems, Inc. Thrombosis filter
US5507767A (en) 1992-01-15 1996-04-16 Cook Incorporated Spiral stent
CA2087132A1 (en) 1992-01-31 1993-08-01 Michael S. Williams Stent capable of attachment within a body lumen
US5405377A (en) 1992-02-21 1995-04-11 Endotech Ltd. Intraluminal stent
US5370683A (en) 1992-03-25 1994-12-06 Cook Incorporated Vascular stent
US5224953A (en) 1992-05-01 1993-07-06 The Beth Israel Hospital Association Method for treatment of obstructive portions of urinary passageways
US5817102A (en) 1992-05-08 1998-10-06 Schneider (Usa) Inc. Apparatus for delivering and deploying a stent
US5324304A (en) * 1992-06-18 1994-06-28 William Cook Europe A/S Introduction catheter set for a collapsible self-expandable implant
FR2694687B1 (en) 1992-08-12 1994-09-30 Celsa Lg Vascular prosthesis for filtering blood in a vessel and interventional device for such temporary filtering.
US5366473A (en) 1992-08-18 1994-11-22 Ultrasonic Sensing And Monitoring Systems, Inc. Method and apparatus for applying vascular grafts
US5527338A (en) 1992-09-02 1996-06-18 Board Of Regents, The University Of Texas System Intravascular device
US5643297A (en) 1992-11-09 1997-07-01 Endovascular Instruments, Inc. Intra-artery obstruction clearing apparatus and methods
US5540707A (en) 1992-11-13 1996-07-30 Scimed Life Systems, Inc. Expandable intravascular occlusion material removal devices and methods of use
US5792157A (en) 1992-11-13 1998-08-11 Scimed Life Systems, Inc. Expandable intravascular occlusion material removal devices and methods of use
US5383926A (en) 1992-11-23 1995-01-24 Children's Medical Center Corporation Re-expandable endoprosthesis
US5318576A (en) 1992-12-16 1994-06-07 Plassche Jr Walter M Endovascular surgery systems
FR2699809B1 (en) 1992-12-28 1995-02-17 Celsa Lg Device which can selectively constitute a temporary blood filter.
US5569274A (en) 1993-02-22 1996-10-29 Heartport, Inc. Endoscopic vascular clamping system and method
US5354310A (en) 1993-03-22 1994-10-11 Cordis Corporation Expandable temporary graft
US5456667A (en) 1993-05-20 1995-10-10 Advanced Cardiovascular Systems, Inc. Temporary stenting catheter with one-piece expandable segment
US5425765A (en) 1993-06-25 1995-06-20 Tiefenbrun; Jonathan Surgical bypass method
US5419774A (en) 1993-07-13 1995-05-30 Scimed Life Systems, Inc. Thrombus extraction device
US5366464A (en) 1993-07-22 1994-11-22 Belknap John C Atherectomy catheter device
US5462529A (en) 1993-09-29 1995-10-31 Technology Development Center Adjustable treatment chamber catheter
US5634897A (en) 1993-10-08 1997-06-03 Lake Region Manufacturing, Inc. Rheolytic occlusion removal catheter system and method
FR2713081B1 (en) 1993-11-29 1996-01-12 Celsa Lg Improved blood filter with two series of petal legs.
DE9319267U1 (en) 1993-12-15 1994-02-24 Vorwerk Dierk Dr Aortic endoprosthesis
US5792300A (en) 1994-01-21 1998-08-11 Cordis Corporation Perfusion catheter and striped extrusion method of manufacture
DE69518275T3 (en) 1994-06-08 2007-10-18 CardioVascular Concepts, Inc., Portola Valley Blood vessel graft
US5683451A (en) 1994-06-08 1997-11-04 Cardiovascular Concepts, Inc. Apparatus and methods for deployment release of intraluminal prostheses
DE9409484U1 (en) 1994-06-11 1994-08-04 Naderlinger Eduard Vena cava thrombus filter
EP0954244A1 (en) 1994-07-01 1999-11-10 SciMed Life Systems, Inc. Intravascular device utilizing fluid to extract occlusive material
US5476104A (en) 1994-08-01 1995-12-19 Sheahon; John A. Cervical and endometrial biopsy instrument
US5512044A (en) 1994-10-11 1996-04-30 Duer; Edward Y. Embolic cutting catheter
US5658296A (en) 1994-11-21 1997-08-19 Boston Scientific Corporation Method for making surgical retrieval baskets
US5709704A (en) 1994-11-30 1998-01-20 Boston Scientific Corporation Blood clot filtering
US5928218A (en) 1994-12-16 1999-07-27 Gelbfish; Gary A. Medical material removal method and associated instrumentation
US5549626A (en) 1994-12-23 1996-08-27 New York Society For The Ruptured And Crippled Maintaining The Hospital For Special Surgery Vena caval filter
JPH08187294A (en) 1995-01-12 1996-07-23 Clinical Supply:Kk Filter for thrombus catching
DE69626105T2 (en) * 1995-03-30 2003-10-23 Heartport Inc ENDOVASCULAR CATHETER FOR LEADING FROM THE HEART
US5795322A (en) 1995-04-10 1998-08-18 Cordis Corporation Catheter with filter and thrombus-discharge device
NL1000105C2 (en) 1995-04-10 1996-10-11 Cordis Europ Catheter with filter and thrombi draining device.
US5807398A (en) * 1995-04-28 1998-09-15 Shaknovich; Alexander Shuttle stent delivery catheter
NL1001410C2 (en) 1995-05-19 1996-11-20 Cordis Europ Medical device for long-term residence in a body.
US5681347A (en) 1995-05-23 1997-10-28 Boston Scientific Corporation Vena cava filter delivery system
US5938645A (en) 1995-05-24 1999-08-17 Boston Scientific Corporation Northwest Technology Center Inc. Percutaneous aspiration catheter system
US5833650A (en) 1995-06-05 1998-11-10 Percusurge, Inc. Catheter apparatus and method for treating occluded vessels
US6280413B1 (en) 1995-06-07 2001-08-28 Medtronic Ave, Inc. Thrombolytic filtration and drug delivery catheter with a self-expanding portion
FR2737653B1 (en) 1995-08-10 1997-09-19 Braun Celsa Sa DEFINITIVE FILTER COMPRISING AN ORIFICE FOR THE PASSAGE OF MEDICAL DEVICES AND ITS MANUFACTURING METHOD
US5925016A (en) 1995-09-27 1999-07-20 Xrt Corp. Systems and methods for drug delivery including treating thrombosis by driving a drug or lytic agent through the thrombus by pressure
US6264663B1 (en) 1995-10-06 2001-07-24 Metamorphic Surgical Devices, Llc Device for removing solid objects from body canals, cavities and organs including an invertable basket
US5779716A (en) 1995-10-06 1998-07-14 Metamorphic Surgical Devices, Inc. Device for removing solid objects from body canals, cavities and organs
US5989281A (en) 1995-11-07 1999-11-23 Embol-X, Inc. Cannula with associated filter and methods of use during cardiac surgery
US5749848A (en) 1995-11-13 1998-05-12 Cardiovascular Imaging Systems, Inc. Catheter system having imaging, balloon angioplasty, and stent deployment capabilities, and method of use for guided stent deployment
US5695519A (en) 1995-11-30 1997-12-09 American Biomed, Inc. Percutaneous filter for carotid angioplasty
US5728066A (en) 1995-12-13 1998-03-17 Daneshvar; Yousef Injection systems and methods
US5827429A (en) 1996-01-18 1998-10-27 Filtertek Inc. Intravenous filter device
NL1002423C2 (en) 1996-02-22 1997-08-25 Cordis Europ Temporary filter catheter.
US5935139A (en) 1996-05-03 1999-08-10 Boston Scientific Corporation System for immobilizing or manipulating an object in a tract
AU3122197A (en) 1996-05-14 1997-12-05 Embol-X, Inc. Aortic occluder with associated filter and methods of use during cardiac surgery
US6544276B1 (en) * 1996-05-20 2003-04-08 Medtronic Ave. Inc. Exchange method for emboli containment
US6050972A (en) * 1996-05-20 2000-04-18 Percusurge, Inc. Guidewire inflation system
US5833644A (en) 1996-05-20 1998-11-10 Percusurge, Inc. Method for emboli containment
US5797952A (en) 1996-06-21 1998-08-25 Localmed, Inc. System and method for delivering helical stents
NL1003497C2 (en) 1996-07-03 1998-01-07 Cordis Europ Catheter with temporary vena-cava filter.
US5669933A (en) 1996-07-17 1997-09-23 Nitinol Medical Technologies, Inc. Removable embolus blood clot filter
US6066158A (en) * 1996-07-25 2000-05-23 Target Therapeutics, Inc. Mechanical clot encasing and removal wire
US5893867A (en) 1996-11-06 1999-04-13 Percusurge, Inc. Stent positioning apparatus and method
US5876367A (en) 1996-12-05 1999-03-02 Embol-X, Inc. Cerebral protection during carotid endarterectomy and downstream vascular protection during other surgeries
FR2758078B1 (en) 1997-01-03 1999-07-16 Braun Celsa Sa BLOOD FILTER WITH IMPROVED PERMEABILITY
US5882329A (en) 1997-02-12 1999-03-16 Prolifix Medical, Inc. Apparatus and method for removing stenotic material from stents
US5800457A (en) * 1997-03-05 1998-09-01 Gelbfish; Gary A. Intravascular filter and associated methodology
US6152946A (en) 1998-03-05 2000-11-28 Scimed Life Systems, Inc. Distal protection device and method
US5814064A (en) 1997-03-06 1998-09-29 Scimed Life Systems, Inc. Distal protection device
US5906618A (en) 1997-03-20 1999-05-25 Vanderbilt University Microcatheter with auxiliary parachute guide structure
WO1998047447A1 (en) 1997-04-23 1998-10-29 Dubrul William R Bifurcated stent and distal protection system
US5954745A (en) 1997-05-16 1999-09-21 Gertler; Jonathan Catheter-filter set having a compliant seal
US6059814A (en) 1997-06-02 2000-05-09 Medtronic Ave., Inc. Filter for filtering fluid in a bodily passageway
US5800525A (en) 1997-06-04 1998-09-01 Vascular Science, Inc. Blood filter
US5848964A (en) 1997-06-06 1998-12-15 Samuels; Shaun Lawrence Wilkie Temporary inflatable filter device and method of use
US5947995A (en) 1997-06-06 1999-09-07 Samuels; Shaun Lawrence Wilkie Method and apparatus for removing blood clots and other objects
US6245088B1 (en) 1997-07-07 2001-06-12 Samuel R. Lowery Retrievable umbrella sieve and method of use
US5941896A (en) 1997-09-08 1999-08-24 Montefiore Hospital And Medical Center Filter and method for trapping emboli during endovascular procedures
FR2768326B1 (en) 1997-09-18 1999-10-22 De Bearn Olivier Despalle TEMPORARY BLOOD FILTER
US5882272A (en) * 1997-09-26 1999-03-16 Caterpillar Inc. Locking differential
US5925063A (en) 1997-09-26 1999-07-20 Khosravi; Farhad Coiled sheet valve, filter or occlusive device and methods of use
US6066149A (en) 1997-09-30 2000-05-23 Target Therapeutics, Inc. Mechanical clot treatment device with distal filter
US5928203A (en) 1997-10-01 1999-07-27 Boston Scientific Corporation Medical fluid infusion and aspiration
US5908435A (en) 1997-10-23 1999-06-01 Samuels; Shaun L. W. Expandable lumen device and method of use
US6013085A (en) 1997-11-07 2000-01-11 Howard; John Method for treating stenosis of the carotid artery
EP1030603B1 (en) 1997-11-12 2008-08-13 Genesis Technologies LLC. Biological passageway occlusion removal
US5989210A (en) 1998-02-06 1999-11-23 Possis Medical, Inc. Rheolytic thrombectomy catheter and method of using same
EP1054634A4 (en) 1998-02-10 2006-03-29 Artemis Medical Inc Entrapping apparatus and method for use
US6206868B1 (en) 1998-03-13 2001-03-27 Arteria Medical Science, Inc. Protective device and method against embolization during treatment of carotid artery disease
US5925060A (en) 1998-03-13 1999-07-20 B. Braun Celsa Covered self-expanding vascular occlusion device
US6007557A (en) 1998-04-29 1999-12-28 Embol-X, Inc. Adjustable blood filtration system
US6511492B1 (en) * 1998-05-01 2003-01-28 Microvention, Inc. Embolectomy catheters and methods for treating stroke and other small vessel thromboembolic disorders
US6051014A (en) * 1998-10-13 2000-04-18 Embol-X, Inc. Percutaneous filtration catheter for valve repair surgery and methods of use
US5989271A (en) 1998-11-09 1999-11-23 Possis Medical, Inc. Flexible tip rheolytic thrombectomy catheter and method of constructing same
US6228076B1 (en) * 1999-01-09 2001-05-08 Intraluminal Therapeutics, Inc. System and method for controlling tissue ablation
US6171327B1 (en) 1999-02-24 2001-01-09 Scimed Life Systems, Inc. Intravascular filter and method
US6277138B1 (en) 1999-08-17 2001-08-21 Scion Cardio-Vascular, Inc. Filter for embolic material mounted on expandable frame
US6277139B1 (en) 1999-04-01 2001-08-21 Scion Cardio-Vascular, Inc. Vascular protection and embolic material retriever
DE19916162A1 (en) 1999-04-11 2000-10-26 Oralia Gmbh Modular dental laser system; has laser unit with soft or hard laser, transfer unit to transmit laser beam to applicator and operation element to control laser unit, along with optional modules
US6068645A (en) 1999-06-07 2000-05-30 Tu; Hosheng Filter system and methods for removing blood clots and biological material
US6179859B1 (en) 1999-07-16 2001-01-30 Baff Llc Emboli filtration system and methods of use
US6179861B1 (en) 1999-07-30 2001-01-30 Incept Llc Vascular device having one or more articulation regions and methods of use
US6530939B1 (en) 1999-07-30 2003-03-11 Incept, Llc Vascular device having articulation region and methods of use
US6214026B1 (en) 1999-07-30 2001-04-10 Incept Llc Delivery system for a vascular device with articulation region
US6203561B1 (en) 1999-07-30 2001-03-20 Incept Llc Integrated vascular device having thrombectomy element and vascular filter and methods of use
US6245087B1 (en) 1999-08-03 2001-06-12 Embol-X, Inc. Variable expansion frame system for deploying medical devices and methods of use
US6142987A (en) 1999-08-03 2000-11-07 Scimed Life Systems, Inc. Guided filter with support wire and methods of use
US6168579B1 (en) 1999-08-04 2001-01-02 Scimed Life Systems, Inc. Filter flush system and methods of use
US6235044B1 (en) * 1999-08-04 2001-05-22 Scimed Life Systems, Inc. Percutaneous catheter and guidewire for filtering during ablation of mycardial or vascular tissue
US6264672B1 (en) 1999-10-25 2001-07-24 Biopsy Sciences, Llc Emboli capturing device
US6171328B1 (en) 1999-11-09 2001-01-09 Embol-X, Inc. Intravascular catheter filter with interlocking petal design and methods of use
US6290710B1 (en) 1999-12-29 2001-09-18 Advanced Cardiovascular Systems, Inc. Embolic protection device

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0472368A2 (en) * 1990-08-21 1992-02-26 Med Institute, Inc. Ablation catheter
US5769816A (en) 1995-11-07 1998-06-23 Embol-X, Inc. Cannula with associated filter
US5662671A (en) 1996-07-17 1997-09-02 Embol-X, Inc. Atherectomy device having trapping and excising means for removal of plaque from the aorta and other arteries
US5827324A (en) * 1997-03-06 1998-10-27 Scimed Life Systems, Inc. Distal protection device
US5846260A (en) 1997-05-08 1998-12-08 Embol-X, Inc. Cannula with a modular filter for filtering embolic material
US5911734A (en) 1997-05-08 1999-06-15 Embol-X, Inc. Percutaneous catheter and guidewire having filter and medical device deployment capabilities

Cited By (140)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9119706B2 (en) 1999-02-24 2015-09-01 Boston Scientific Scimed Inc. Intravascular filter and method
USRE43882E1 (en) 1999-07-30 2012-12-25 Incept, Llc Vascular device for emboli, thrombus and foreign body removal and methods of use
US9283066B2 (en) 1999-07-30 2016-03-15 Incept Llc Vascular device for emboli, thrombus and foreign body removal and methods of use
US8617201B2 (en) 1999-07-30 2013-12-31 Incept Llc Vascular device for emboli, thrombus and foreign body removal and methods of use
USRE43902E1 (en) 1999-07-30 2013-01-01 Incept, Llc Vascular device for emboli, thrombus and foreign body removal and methods of use
US6814740B2 (en) 1999-10-27 2004-11-09 Scimed Life Systems, Inc. Retrieval device made of precursor alloy cable
US8221434B2 (en) 1999-10-27 2012-07-17 Boston Scientific Scimed, Inc. Retrieval device made of precursor alloy cable
US10278805B2 (en) 2000-08-18 2019-05-07 Atritech, Inc. Expandable implant devices for filtering blood flow from atrial appendages
US6974468B2 (en) 2001-02-28 2005-12-13 Scimed Life Systems, Inc. Filter retrieval catheter
US8267956B2 (en) 2001-10-19 2012-09-18 Incept, Llc Vascular embolic filter exchange devices and methods of use thereof
US7987994B2 (en) 2003-02-24 2011-08-02 Boston Scientific Scimed, Inc. Flexible tube for cartridge filter
US8007510B2 (en) 2003-02-24 2011-08-30 Boston Scientific Scimed, Inc. Embolic protection filtering device that can be adapted to be advanced over a guidewire
US8287564B2 (en) 2003-02-24 2012-10-16 Boston Scientific Scimed, Inc. Embolic protection filtering device that can be adapted to be advanced over a guidewire
US9301829B2 (en) 2003-07-30 2016-04-05 Boston Scientific Scimed, Inc. Embolic protection aspirator
US10772724B2 (en) 2003-12-23 2020-09-15 Boston Scientific Scimed, Inc. Medical devices and delivery systems for delivering medical devices
US10357359B2 (en) 2003-12-23 2019-07-23 Boston Scientific Scimed Inc Methods and apparatus for endovascularly replacing a patient's heart valve
US8231670B2 (en) 2003-12-23 2012-07-31 Sadra Medical, Inc. Repositionable heart valve and method
US8246678B2 (en) 2003-12-23 2012-08-21 Sadra Medicl, Inc. Methods and apparatus for endovascularly replacing a patient's heart valve
US8252052B2 (en) 2003-12-23 2012-08-28 Sadra Medical, Inc. Methods and apparatus for endovascularly replacing a patient's heart valve
US11185408B2 (en) 2003-12-23 2021-11-30 Boston Scientific Scimed, Inc. Methods and apparatus for endovascular heart valve replacement comprising tissue grasping elements
US11278398B2 (en) 2003-12-23 2022-03-22 Boston Scientific Scimed, Inc. Methods and apparatus for endovascular heart valve replacement comprising tissue grasping elements
US8048153B2 (en) 2003-12-23 2011-11-01 Sadra Medical, Inc. Low profile heart valve and delivery system
US11285002B2 (en) 2003-12-23 2022-03-29 Boston Scientific Scimed, Inc. Methods and apparatus for endovascularly replacing a heart valve
US7988724B2 (en) 2003-12-23 2011-08-02 Sadra Medical, Inc. Systems and methods for delivering a medical implant
US7959672B2 (en) 2003-12-23 2011-06-14 Sadra Medical Replacement valve and anchor
US8343213B2 (en) 2003-12-23 2013-01-01 Sadra Medical, Inc. Leaflet engagement elements and methods for use thereof
US8579962B2 (en) 2003-12-23 2013-11-12 Sadra Medical, Inc. Methods and apparatus for performing valvuloplasty
US8603160B2 (en) 2003-12-23 2013-12-10 Sadra Medical, Inc. Method of using a retrievable heart valve anchor with a sheath
US7959666B2 (en) 2003-12-23 2011-06-14 Sadra Medical, Inc. Methods and apparatus for endovascularly replacing a heart valve
US10925724B2 (en) 2003-12-23 2021-02-23 Boston Scientific Scimed, Inc. Replacement valve and anchor
US8840663B2 (en) 2003-12-23 2014-09-23 Sadra Medical, Inc. Repositionable heart valve method
US8840662B2 (en) 2003-12-23 2014-09-23 Sadra Medical, Inc. Repositionable heart valve and method
US8858620B2 (en) 2003-12-23 2014-10-14 Sadra Medical Inc. Methods and apparatus for endovascularly replacing a heart valve
US8894703B2 (en) 2003-12-23 2014-11-25 Sadra Medical, Inc. Systems and methods for delivering a medical implant
US10716663B2 (en) 2003-12-23 2020-07-21 Boston Scientific Scimed, Inc. Methods and apparatus for performing valvuloplasty
US10478289B2 (en) 2003-12-23 2019-11-19 Boston Scientific Scimed, Inc. Replacement valve and anchor
US8951299B2 (en) 2003-12-23 2015-02-10 Sadra Medical, Inc. Medical devices and delivery systems for delivering medical devices
US10426608B2 (en) 2003-12-23 2019-10-01 Boston Scientific Scimed, Inc. Repositionable heart valve
US10413412B2 (en) 2003-12-23 2019-09-17 Boston Scientific Scimed, Inc. Methods and apparatus for endovascularly replacing a heart valve
US9005273B2 (en) 2003-12-23 2015-04-14 Sadra Medical, Inc. Assessing the location and performance of replacement heart valves
US9011521B2 (en) 2003-12-23 2015-04-21 Sadra Medical, Inc. Methods and apparatus for endovascularly replacing a patient's heart valve
US7824443B2 (en) 2003-12-23 2010-11-02 Sadra Medical, Inc. Medical implant delivery and deployment tool
US10413409B2 (en) 2003-12-23 2019-09-17 Boston Scientific Scimed, Inc. Systems and methods for delivering a medical implant
US10335273B2 (en) 2003-12-23 2019-07-02 Boston Scientific Scimed Inc. Leaflet engagement elements and methods for use thereof
US9277991B2 (en) 2003-12-23 2016-03-08 Boston Scientific Scimed, Inc. Low profile heart valve and delivery system
US7824442B2 (en) 2003-12-23 2010-11-02 Sadra Medical, Inc. Methods and apparatus for endovascularly replacing a heart valve
US10314695B2 (en) 2003-12-23 2019-06-11 Boston Scientific Scimed Inc. Methods and apparatus for endovascular heart valve replacement comprising tissue grasping elements
US9308085B2 (en) 2003-12-23 2016-04-12 Boston Scientific Scimed, Inc. Repositionable heart valve and method
US9320599B2 (en) 2003-12-23 2016-04-26 Boston Scientific Scimed, Inc. Methods and apparatus for endovascularly replacing a heart valve
US9358110B2 (en) 2003-12-23 2016-06-07 Boston Scientific Scimed, Inc. Medical devices and delivery systems for delivering medical devices
US9358106B2 (en) 2003-12-23 2016-06-07 Boston Scientific Scimed Inc. Methods and apparatus for performing valvuloplasty
US7748389B2 (en) 2003-12-23 2010-07-06 Sadra Medical, Inc. Leaflet engagement elements and methods for use thereof
US9387076B2 (en) 2003-12-23 2016-07-12 Boston Scientific Scimed Inc. Medical devices and delivery systems for delivering medical devices
US9393113B2 (en) 2003-12-23 2016-07-19 Boston Scientific Scimed Inc. Retrievable heart valve anchor and method
US10258465B2 (en) 2003-12-23 2019-04-16 Boston Scientific Scimed Inc. Methods and apparatus for endovascular heart valve replacement comprising tissue grasping elements
US10206774B2 (en) 2003-12-23 2019-02-19 Boston Scientific Scimed Inc. Low profile heart valve and delivery system
US9861476B2 (en) 2003-12-23 2018-01-09 Boston Scientific Scimed Inc. Leaflet engagement elements and methods for use thereof
US9526609B2 (en) 2003-12-23 2016-12-27 Boston Scientific Scimed, Inc. Methods and apparatus for endovascularly replacing a patient's heart valve
US9532872B2 (en) 2003-12-23 2017-01-03 Boston Scientific Scimed, Inc. Systems and methods for delivering a medical implant
US8182528B2 (en) 2003-12-23 2012-05-22 Sadra Medical, Inc. Locking heart valve anchor
US9585750B2 (en) 2003-12-23 2017-03-07 Boston Scientific Scimed, Inc. Methods and apparatus for endovascularly replacing a patient's heart valve
US9585749B2 (en) 2003-12-23 2017-03-07 Boston Scientific Scimed, Inc. Replacement heart valve assembly
US11696825B2 (en) 2003-12-23 2023-07-11 Boston Scientific Scimed, Inc. Replacement valve and anchor
US9956075B2 (en) 2003-12-23 2018-05-01 Boston Scientific Scimed Inc. Methods and apparatus for endovascularly replacing a heart valve
US9872768B2 (en) 2003-12-23 2018-01-23 Boston Scientific Scimed, Inc. Medical devices and delivery systems for delivering medical devices
US8668733B2 (en) 2004-06-16 2014-03-11 Sadra Medical, Inc. Everting heart valve
US11484405B2 (en) 2004-06-16 2022-11-01 Boston Scientific Scimed, Inc. Everting heart valve
US9744035B2 (en) 2004-06-16 2017-08-29 Boston Scientific Scimed, Inc. Everting heart valve
US8992608B2 (en) 2004-06-16 2015-03-31 Sadra Medical, Inc. Everting heart valve
US7780725B2 (en) 2004-06-16 2010-08-24 Sadra Medical, Inc. Everting heart valve
US8328868B2 (en) 2004-11-05 2012-12-11 Sadra Medical, Inc. Medical devices and delivery systems for delivering medical devices
US10531952B2 (en) 2004-11-05 2020-01-14 Boston Scientific Scimed, Inc. Medical devices and delivery systems for delivering medical devices
US11517431B2 (en) 2005-01-20 2022-12-06 Jenavalve Technology, Inc. Catheter system for implantation of prosthetic heart valves
US9415225B2 (en) 2005-04-25 2016-08-16 Cardiac Pacemakers, Inc. Method and apparatus for pacing during revascularization
US10549101B2 (en) 2005-04-25 2020-02-04 Cardiac Pacemakers, Inc. Method and apparatus for pacing during revascularization
US9649495B2 (en) 2005-04-25 2017-05-16 Cardiac Pacemakers, Inc. Method and apparatus for pacing during revascularization
US7712606B2 (en) 2005-09-13 2010-05-11 Sadra Medical, Inc. Two-part package for medical implant
US10370150B2 (en) 2005-09-13 2019-08-06 Boston Scientific Scimed Inc. Two-part package for medical implant
US8136659B2 (en) 2005-09-13 2012-03-20 Sadra Medical, Inc. Two-part package for medical implant
US9393094B2 (en) 2005-09-13 2016-07-19 Boston Scientific Scimed, Inc. Two-part package for medical implant
US8287584B2 (en) 2005-11-14 2012-10-16 Sadra Medical, Inc. Medical implant deployment tool
US10299922B2 (en) 2005-12-22 2019-05-28 Symetis Sa Stent-valves for valve replacement and associated methods and systems for surgery
US10314701B2 (en) 2005-12-22 2019-06-11 Symetis Sa Stent-valves for valve replacement and associated methods and systems for surgery
US11357624B2 (en) 2007-04-13 2022-06-14 Jenavalve Technology, Inc. Medical device for treating a heart valve insufficiency
US11564794B2 (en) 2008-02-26 2023-01-31 Jenavalve Technology, Inc. Stent for the positioning and anchoring of a valvular prosthesis in an implantation site in the heart of a patient
US10993805B2 (en) 2008-02-26 2021-05-04 Jenavalve Technology, Inc. Stent for the positioning and anchoring of a valvular prosthesis in an implantation site in the heart of a patient
US11154398B2 (en) 2008-02-26 2021-10-26 JenaValve Technology. Inc. Stent for the positioning and anchoring of a valvular prosthesis in an implantation site in the heart of a patient
US11589981B2 (en) 2010-05-25 2023-02-28 Jenavalve Technology, Inc. Prosthetic heart valve and transcatheter delivered endoprosthesis comprising a prosthetic heart valve and a stent
US10869760B2 (en) 2010-09-10 2020-12-22 Symetis Sa Valve replacement devices, delivery device for a valve replacement device and method of production of a valve replacement device
US10201418B2 (en) 2010-09-10 2019-02-12 Symetis, SA Valve replacement devices, delivery device for a valve replacement device and method of production of a valve replacement device
US11771544B2 (en) 2011-05-05 2023-10-03 Symetis Sa Method and apparatus for compressing/loading stent-valves
US8998976B2 (en) 2011-07-12 2015-04-07 Boston Scientific Scimed, Inc. Coupling system for medical devices
US9555219B2 (en) 2011-11-10 2017-01-31 Boston Scientific Scimed, Inc. Direct connect flush system
US9131926B2 (en) 2011-11-10 2015-09-15 Boston Scientific Scimed, Inc. Direct connect flush system
US9642705B2 (en) 2011-11-15 2017-05-09 Boston Scientific Scimed Inc. Bond between components of a medical device
US10478300B2 (en) 2011-11-15 2019-11-19 Boston Scientific Scimed, Inc. Bond between components of a medical device
US8940014B2 (en) 2011-11-15 2015-01-27 Boston Scientific Scimed, Inc. Bond between components of a medical device
US9370421B2 (en) 2011-12-03 2016-06-21 Boston Scientific Scimed, Inc. Medical device handle
US8951243B2 (en) 2011-12-03 2015-02-10 Boston Scientific Scimed, Inc. Medical device handle
US9277993B2 (en) 2011-12-20 2016-03-08 Boston Scientific Scimed, Inc. Medical device delivery systems
US9510945B2 (en) 2011-12-20 2016-12-06 Boston Scientific Scimed Inc. Medical device handle
US10172708B2 (en) 2012-01-25 2019-01-08 Boston Scientific Scimed, Inc. Valve assembly with a bioabsorbable gasket and a replaceable valve implant
US11382739B2 (en) 2012-06-19 2022-07-12 Boston Scientific Scimed, Inc. Replacement heart valve
US10555809B2 (en) 2012-06-19 2020-02-11 Boston Scientific Scimed, Inc. Replacement heart valve
US11185405B2 (en) 2013-08-30 2021-11-30 Jenavalve Technology, Inc. Radially collapsible frame for a prosthetic valve and method for manufacturing such a frame
US9901445B2 (en) 2014-11-21 2018-02-27 Boston Scientific Scimed, Inc. Valve locking mechanism
US10449043B2 (en) 2015-01-16 2019-10-22 Boston Scientific Scimed, Inc. Displacement based lock and release mechanism
US9861477B2 (en) 2015-01-26 2018-01-09 Boston Scientific Scimed Inc. Prosthetic heart valve square leaflet-leaflet stitch
US10201417B2 (en) 2015-02-03 2019-02-12 Boston Scientific Scimed Inc. Prosthetic heart valve having tubular seal
US9788942B2 (en) 2015-02-03 2017-10-17 Boston Scientific Scimed Inc. Prosthetic heart valve having tubular seal
US10426617B2 (en) 2015-03-06 2019-10-01 Boston Scientific Scimed, Inc. Low profile valve locking mechanism and commissure assembly
US10285809B2 (en) 2015-03-06 2019-05-14 Boston Scientific Scimed Inc. TAVI anchoring assist device
US10080652B2 (en) 2015-03-13 2018-09-25 Boston Scientific Scimed, Inc. Prosthetic heart valve having an improved tubular seal
US11337800B2 (en) 2015-05-01 2022-05-24 Jenavalve Technology, Inc. Device and method with reduced pacemaker rate in heart valve replacement
US11730595B2 (en) 2015-07-02 2023-08-22 Boston Scientific Scimed, Inc. Adjustable nosecone
US10195392B2 (en) 2015-07-02 2019-02-05 Boston Scientific Scimed, Inc. Clip-on catheter
US10335277B2 (en) 2015-07-02 2019-07-02 Boston Scientific Scimed Inc. Adjustable nosecone
US10136991B2 (en) 2015-08-12 2018-11-27 Boston Scientific Scimed Inc. Replacement heart valve implant
US10856973B2 (en) 2015-08-12 2020-12-08 Boston Scientific Scimed, Inc. Replacement heart valve implant
US10179041B2 (en) 2015-08-12 2019-01-15 Boston Scientific Scimed Icn. Pinless release mechanism
US10779940B2 (en) 2015-09-03 2020-09-22 Boston Scientific Scimed, Inc. Medical device handle
US10342660B2 (en) 2016-02-02 2019-07-09 Boston Scientific Inc. Tensioned sheathing aids
US10245136B2 (en) 2016-05-13 2019-04-02 Boston Scientific Scimed Inc. Containment vessel with implant sheathing guide
US11382742B2 (en) 2016-05-13 2022-07-12 Boston Scientific Scimed, Inc. Medical device handle
US11065138B2 (en) 2016-05-13 2021-07-20 Jenavalve Technology, Inc. Heart valve prosthesis delivery system and method for delivery of heart valve prosthesis with introducer sheath and loading system
US10709552B2 (en) 2016-05-16 2020-07-14 Boston Scientific Scimed, Inc. Replacement heart valve implant with invertible leaflets
US20170325938A1 (en) 2016-05-16 2017-11-16 Boston Scientific Scimed, Inc. Replacement heart valve implant with invertible leaflets
US10201416B2 (en) 2016-05-16 2019-02-12 Boston Scientific Scimed, Inc. Replacement heart valve implant with invertible leaflets
US10828154B2 (en) 2017-06-08 2020-11-10 Boston Scientific Scimed, Inc. Heart valve implant commissure support structure
US10898325B2 (en) 2017-08-01 2021-01-26 Boston Scientific Scimed, Inc. Medical implant locking mechanism
US10939996B2 (en) 2017-08-16 2021-03-09 Boston Scientific Scimed, Inc. Replacement heart valve commissure assembly
US11246625B2 (en) 2018-01-19 2022-02-15 Boston Scientific Scimed, Inc. Medical device delivery system with feedback loop
US11191641B2 (en) 2018-01-19 2021-12-07 Boston Scientific Scimed, Inc. Inductance mode deployment sensors for transcatheter valve system
US11147668B2 (en) 2018-02-07 2021-10-19 Boston Scientific Scimed, Inc. Medical device delivery system with alignment feature
US11439732B2 (en) 2018-02-26 2022-09-13 Boston Scientific Scimed, Inc. Embedded radiopaque marker in adaptive seal
US11229517B2 (en) 2018-05-15 2022-01-25 Boston Scientific Scimed, Inc. Replacement heart valve commissure assembly
US11241310B2 (en) 2018-06-13 2022-02-08 Boston Scientific Scimed, Inc. Replacement heart valve delivery device
US11241312B2 (en) 2018-12-10 2022-02-08 Boston Scientific Scimed, Inc. Medical device delivery system including a resistance member
US11439504B2 (en) 2019-05-10 2022-09-13 Boston Scientific Scimed, Inc. Replacement heart valve with improved cusp washout and reduced loading
WO2022073922A1 (en) * 2020-10-08 2022-04-14 Biotronik Ag Catheter device for performing a cardiac sympathetic denervation intervention

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ATE296061T1 (en) 2005-06-15
US20040093016A1 (en) 2004-05-13
EP1294299B1 (en) 2005-05-25
JP2004509650A (en) 2004-04-02
US6235044B1 (en) 2001-05-22
US6673090B2 (en) 2004-01-06
CA2378594C (en) 2010-11-09
US20010005789A1 (en) 2001-06-28
EP1294299A1 (en) 2003-03-26
US7326226B2 (en) 2008-02-05
CA2378594A1 (en) 2001-02-15
US20080097426A1 (en) 2008-04-24

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