WO2000072858A1 - Composition d'additif alimentaire destine au traitement preventif de la coccidiose - Google Patents

Composition d'additif alimentaire destine au traitement preventif de la coccidiose Download PDF

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Publication number
WO2000072858A1
WO2000072858A1 PCT/FR2000/001419 FR0001419W WO0072858A1 WO 2000072858 A1 WO2000072858 A1 WO 2000072858A1 FR 0001419 W FR0001419 W FR 0001419W WO 0072858 A1 WO0072858 A1 WO 0072858A1
Authority
WO
WIPO (PCT)
Prior art keywords
tannin
food additive
coccidiosis
tannins
food
Prior art date
Application number
PCT/FR2000/001419
Other languages
English (en)
French (fr)
Inventor
Jean-Benoît TIERNY
Original Assignee
Ecopsi
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ecopsi filed Critical Ecopsi
Priority to AU50816/00A priority Critical patent/AU5081600A/en
Priority to BR0011020-5A priority patent/BR0011020A/pt
Priority to EP00935257A priority patent/EP1181028A1/fr
Publication of WO2000072858A1 publication Critical patent/WO2000072858A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/49—Fagaceae (Beech family), e.g. oak or chestnut
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis

Definitions

  • the present invention relates to a food additive composition for the preventive treatment of coccidiosis.
  • the present invention also relates to a nutritional composition containing this additive and which makes it possible to treat coccidiosis as a preventive measure.
  • Coccidiosis is a disease of the intestines, the pathogens of which are protozoa which gradually invade the intestinal epithelium, preventing the absorption of nutrients and causing weight loss in the contaminated individual, which may even lead to death.
  • Coccidioses affect both mammals, such as cattle or humans, as well as birds, in which, with certain highly pathogenic species, they can cause death. In humans, it can also be dangerous, especially if the immune system is weakened.
  • Synthetic antibiotics, ionophores and other non-antibiotic synthetics are commonly used to treat coccidiosis.
  • the document WO 96/13175 recommends in the case of poultry, the use of a food additive containing a mixture of cresols, guaiacol, thymol, anethol, eugenol, capsaine and tannin in combination with an emulsifying agent.
  • This mixture does not have a microbicidal effect on sporulated coccidia oocysts but, on the other hand, blocks reinfestation after the first passage of coccidia in the digestive tract of poultry.
  • composition of food additive based on natural essential oils easily assimilated or degradable by the body has few or no side effects and above all does not cause any accumulation of active substances in the tissues.
  • the object of the present invention is therefore to propose a food additive composition for the preventive treatment of coccidiosis, the manufacture of which is economically advantageous.
  • a food additive composition intended for the preventive treatment of coccidiosis which typically according to the invention exclusively contains a tannin or a mixture of tannins as active ingredient.
  • the food additive therefore contains as sole active ingredient one or more tannins, in particular to the exclusion of essential oils. It is therefore the merit of the Applicant to have demonstrated that the tannin alone is particularly active in the preventive treatment of coccidiosis.
  • the known food compositions intended for the treatment of coccidiosis all contain essential oils.
  • the present invention also relates to a food additive composition intended for the preventive treatment of coccidiosis which typically contains exclusively a tannin or a mixture of tannins as active ingredient chosen from tannins of oak and chestnut.
  • a food additive composition intended for the preventive treatment of coccidiosis which typically contains exclusively a tannin or a mixture of tannins as active ingredient chosen from tannins of oak and chestnut.
  • the Applicant has also demonstrated that these two tannins prove to be particularly stable in particular to heat and to light.
  • the use of the two aforementioned tannins, alone or as a mixture makes it possible to obtain a particularly stable food additive whatever the duration and the conditions of its storage.
  • the compositions containing essential oils are in fact particularly sensitive to light and to heat, which limits their duration of storage or imposes storage conditions which are difficult to achieve or to maintain in particular on operating sites such as, for example, poultry farm sites.
  • the Applicant has also demonstrated that these two tannins form bonds with proteins which are easily hydrolyzable at the pH prevailing in the digestive tract of animals and in particular chicken.
  • the use of the two aforementioned particular tannins therefore makes it possible to obtain a composition of food additive whose preventive activity on coccidiosis is stable whatever the duration and the storage conditions of the composition and which, moreover , born not block protein digestion. It is therefore the merit of the Applicant to have chosen the two aforementioned particular tannins which have both good stability and do not block the assimilation of proteins.
  • the origin of the tannin or tannins in the mixture of tannins is not limited according to the invention. These tannins can be synthetic or natural.
  • the tannin or tannins in the mixture are obtained by leaching the wood, preferably oak or chestnut.
  • the form in which the tannin is used is not limitative of the invention. It is possible, for example, to use a particularly aqueous solution containing the tannin (s). Preferably, the tannin or tannins are used in the form of dry powder which facilitates their mixing to obtain a nutritional composition.
  • the present invention also relates to a nutritional composition intended for the preventive treatment of coccidiosis, which typically contains, as the sole active ingredient, the food additive composition of the invention.
  • the nutritional composition of the invention contains at least 0.1% by mass of tannin (s) provided by the food additive of the invention.
  • tannin s
  • the Applicant has in fact demonstrated that this percentage ensures real effectiveness of the nutritional composition on the preventive treatment of coccidiosis.
  • the nutritional composition of the invention contains at least 0.150% by tannin mass (s) provided by the food additive of the invention.
  • the nutritional composition of the invention contains between 0.1% and 1% by tannin mass (s) provided by the food additive of the invention.
  • the nutritional composition of the invention contains between 0.150% and 1% by tannin mass (s) provided by the food additive of the invention.
  • Such amounts of tannins confer satisfactory activity on the food composition of the invention; moreover, their links with proteins remain easily hydrolyzable in the digestive tract and therefore do not prevent the assimilation of proteins.
  • the tannin used in the particular examples which follow is a tannin or a mixture of tannins extracted from chestnut wood.
  • Preparation of the tannin The tannin used is obtained by steam leaching of chestnut wood shavings. The solution is then evaporated and atomized to obtain a dry extract which represents 95% (+ - 1%) by mass of the initial aqueous solution. This dry extract contains 77% by mass of chestnut tannin (s). The remaining 23% of the dry extract consists of water (5%), ash and tannin precursor sugars (18%).
  • This chestnut wood extract is mixed with the chicken food so as to obtain a mixture containing 0.2% by mass of chestnut wood extract with 77% tannin (s) or a percentage of 0.154% by mass of chestnut tannin (s).
  • Each treatment was carried out on three groups of 30 battery chickens, male and female of the breed "Ross 208", aged 360 days.
  • the chickens were fed with the nutritional compositions indicated in table 1, under standard temperature, lighting and ventilation conditions.
  • the departure period extends from 0 to two weeks after the start of the experience while the period fattening period extends from 2 to 6 weeks after the start of the experiment.
  • the chickens have also been vaccinated against the Newcasttle virus (by Hitchner spray) and against bronchitis (by H120 spray). Food and water were provided ad libitum.
  • the nutritional compositions also include agents preventing the proliferation of the coccidia contained in the “Premix” mixture.
  • Table 2 groups together the four groups and the percentage of chestnut extract which was respectively incorporated into the nutritional compositions.
  • Table 3 provides a statistical analysis of the results.
  • the chicks were divided into four main groups. Each of these main groups was then divided into two subgroups of 24 chicks (respectively 1 CS, 1TS, 2CS, 2TS, 3CC, 3TC, 4CC, 4TC) which allows to combine subgroups of chicks having received chestnut extract in the same cage but in separate compartments. This strategy makes it possible to determine the influence of environmental conditions on the statistical analyzes of the results obtained.
  • the animals of groups 1TS, 2TS, 3TC and 4TC were fed with a food containing 0.2% by weight of chestnut extract.
  • the animals of groups 1 CS, 2CS, 3CC and 4CC were fed with the same food but not containing the extract of chestnut.
  • the droppings of the chicks are collected every five days on paper placed under the cages. Micro-biological methods used The action of the chestnut extract on the ejection of Eimeria sp. was studied on chick droppings collected five days apart. The droppings are then quantitatively analyzed by flotation to determine the number of Eimeria sp eggs they contain. Detection of Eimeria sp in chicken droppings
  • the filtrate is homogenized by successive transfer to another beaker (repeated 10 times) and introduced into a McMaster chamber using a pasteur pipette.
  • the chamber is left to stand for 2 minutes and then placed under a microscope.
  • the magnification used is 100x.
  • the eggs of Eimeria sp are then counted
  • the total number of Eimeria sp. is obtained by multiplying by 50 the total number of eggs of Eimeria sp. determined in the room. The sensitivity of the test is 50.
  • Table 4 represents the subdivisions within each sub-group; the chicks are placed in boxes of four compartments each containing 6 birds. Groups 1 and 2 were further contaminated by injection of 104 cfu / chick of Salmonella Entendis PT4 (NIDO 76Sa88) by gavage at the age of 6 days.
  • Graph 1 represents the total number of Eimeria sp eggs collected respectively for the control group and the groups treated with tannin.
  • Graph 2 represents the number of Eimeria sp eggs collected from the droppings of chickens contaminated with Salmonella. We note that in this case, the chicks which ingested tannin are less contaminated by Eimeria sp than the chicks which did not ingest tannin. Table 5 groups together the number of eggs collected in the droppings of each of the groups defined in Table 4.
  • Graph 4 represents the weight gain of the different groups of 55-day-old chicks. It is noted that the CS and TS groups which have absorbed tannin have a greater average weight gain than the groups which have not been treated with tannin. So it would seem that, even in the case of contamination by Saimonella, the ingestion of tannin favors the weight gain of individuals without nevertheless having a direct influence on Salmonella itself.
  • the Premix provides 100 mg of monensin (for the period of 0-2 weeks), 1 mg of diclazuril (-Clinacox) (for the period of 2-6 weeks) and 15 mg of virginiamycin per kg of food.
PCT/FR2000/001419 1999-05-28 2000-05-25 Composition d'additif alimentaire destine au traitement preventif de la coccidiose WO2000072858A1 (fr)

Priority Applications (3)

Application Number Priority Date Filing Date Title
AU50816/00A AU5081600A (en) 1999-05-28 2000-05-25 Food additive composition for preventive treatment of coccidiosis
BR0011020-5A BR0011020A (pt) 1999-05-28 2000-05-25 Composição de aditivo alimentar para o tratamento preventivo de coccidiose
EP00935257A EP1181028A1 (fr) 1999-05-28 2000-05-25 Composition d'additif alimentaire destine au traitement preventif de la coccidiose

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR99/06917 1999-05-28
FR9906917A FR2794024B1 (fr) 1999-05-28 1999-05-28 Preparation a base de tanin(s) destinee au traitement de la coccidiose

Publications (1)

Publication Number Publication Date
WO2000072858A1 true WO2000072858A1 (fr) 2000-12-07

Family

ID=9546251

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/FR2000/001419 WO2000072858A1 (fr) 1999-05-28 2000-05-25 Composition d'additif alimentaire destine au traitement preventif de la coccidiose

Country Status (5)

Country Link
EP (1) EP1181028A1 (fi)
AU (1) AU5081600A (fi)
BR (1) BR0011020A (fi)
FR (1) FR2794024B1 (fi)
WO (1) WO2000072858A1 (fi)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2510808A1 (fr) * 2011-04-11 2012-10-17 T L Utilisation de tanins hydrolysables dans l'alimentation animale
FR3124947A1 (fr) * 2021-07-12 2023-01-13 Societe D'exploitation De Produits Pour Les Industries Chimiques Seppic Composition ingérable (Ci) pour une utilisation dans le traitement d’un trouble cutané induit par un trouble intestinal

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996013175A1 (fr) * 1994-10-26 1996-05-09 Crina S.A. Composition d'additif pour aliments destines a la volaille
WO1997007812A1 (en) * 1995-08-25 1997-03-06 Jasna Mandic Production process of the ecological pharmaceutical compositions in the veterinary medical field

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996013175A1 (fr) * 1994-10-26 1996-05-09 Crina S.A. Composition d'additif pour aliments destines a la volaille
WO1997007812A1 (en) * 1995-08-25 1997-03-06 Jasna Mandic Production process of the ecological pharmaceutical compositions in the veterinary medical field

Also Published As

Publication number Publication date
BR0011020A (pt) 2002-08-27
AU5081600A (en) 2000-12-18
EP1181028A1 (fr) 2002-02-27
FR2794024A1 (fr) 2000-12-01
FR2794024B1 (fr) 2001-08-17

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