WO2000019912A1 - Device for the occlusion of a puncture in a bodily duct - Google Patents
Device for the occlusion of a puncture in a bodily duct Download PDFInfo
- Publication number
- WO2000019912A1 WO2000019912A1 PCT/AU1999/000847 AU9900847W WO0019912A1 WO 2000019912 A1 WO2000019912 A1 WO 2000019912A1 AU 9900847 W AU9900847 W AU 9900847W WO 0019912 A1 WO0019912 A1 WO 0019912A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- plug
- puncture
- delivery sheath
- sheath
- proximal end
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/0057—Implements for plugging an opening in the wall of a hollow or tubular organ, e.g. for sealing a vessel puncture or closing a cardiac septal defect
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/0057—Implements for plugging an opening in the wall of a hollow or tubular organ, e.g. for sealing a vessel puncture or closing a cardiac septal defect
- A61B2017/00637—Implements for plugging an opening in the wall of a hollow or tubular organ, e.g. for sealing a vessel puncture or closing a cardiac septal defect for sealing trocar wounds through abdominal wall
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/0057—Implements for plugging an opening in the wall of a hollow or tubular organ, e.g. for sealing a vessel puncture or closing a cardiac septal defect
- A61B2017/00646—Type of implements
- A61B2017/00654—Type of implements entirely comprised between the two sides of the opening
Definitions
- the present invention relates to a method and means for the occlusion of a puncture in the wall of a bodily duct, such as an artery. More particularly, the invention relates to a method and means for the occlusion of punctures formed in the walls of arteries during intraluminal operative procedures.
- This problem is typically dealt with by applying manual pressure to the wound site until the natural blood clotting mechanisms have had time to operate and seal the puncture. This can be time consuming and interrupt the flow of the operative procedure. Alternatively, a cut-down can be performed and the puncture sutured. However, this also is time consuming and requires a high level of surgical skill to perform.
- the present invention is designed to provide an alternative to the known methods and devices for the occlusion of punctures in the walls of bodily ducts.
- a device for the occlusion of a puncture in the wall of a bodily duct comprising a resiliently compressible plug that can be introduced into the puncture from externally of the body, and introduction means adapted to introduce the plug into the puncture in a radially compressed state and to then release the plug within the puncture so that it may expand to occlude the puncture.
- a method for occluding a puncture in the wall of a bodily duct including the steps of:-
- the plug is formed with a region of reduced cross sectional area intermediate its ends.
- This region of reduced cross- sectional area is preferably bounded on at least one side, at the proximal end of the plug, by an enlargement such that once the plug has been deployed in the puncture and allowed to expand, it will resist withdrawal in a direction away from the, or each, enlargement.
- the cross-sectional shape and size of the intermediate region of the plug should be such that the intermediate region is able to occlude the puncture. Unlike the arrangements of known devices which are designed to bring about instantaneous haemostasis, in the present invention, it is the presence of the plug in the puncture that brings about its occlusion.
- the prior art devices require pressure on either side of the wall around the puncture to bring about occlusion.
- the enlargements of the plug on one or each side of the intermediate region of the plug serve to assist in preventing the plug from being displaced from the puncture.
- the enlargement at the proximal end of the plug is convex on its side facing into the bodily duct with a relatively long radius of curvature.
- the plug then presents a smooth profile to blood flowing past it.
- the distal end of the plug which projects outwardly from the wall of the bodily duct, is preferably formed with ridges, or other projections that will inhibit movement of the plug towards the lumen of the vessel.
- different parts of the plug could be formed of material having different degrees of resilience.
- the plug could, for instance, have the enlargement or enlargements formed of a less dense, more resilient sponge than the intermediate region of the plug.
- the face of the enlargement facing into the lumen of the bodily duct is preferably provided with an anti-coagulant coating.
- the plug is preferably formed from a resorbable polymer or polycarbonate foam or sponge material.
- the plug is formed of a polymer sponge that has an expansion ratio of from about 1.5:1 up to about 10:1.
- the plug may also be made, or partly constructed, of collagen sponge. It may be made partly of a resorbable material and partly of a non-resorbable material.
- the plug may however be made entirely of a non-resorbable material provided that it is bio- compatible and will not set up an inflammatory, or other, reaction in the patient.
- the plug is made from polyurethane.
- the different parts of the plug may be made from different types of material, for instance, the proximal end of the plug may be made from a resorbable material while the remainder of the plug may be made from a non-resorbable material.
- the material of the plug may be naturally resilient such that it will spring back into shape as soon as a compressive pressure has been removed.
- the plug may be formed of a material that is compressed or contracted through dehydration. In this case the resilience comes from the rehydration of the material forming the plug causing it to swell and occlude a puncture into which it has been placed.
- the plug may contain within its structure, metallic wires or wireforms. These wires may be withdrawable after the plug has been deployed, or may. in the case of a non-resorbable plug, be a permanent part of the plug.
- these wires may be formed of Nitinol or another material that will change shape at the temperature of blood. In this way the wires could be designed to unfold like the ribs of an umbrella upon the proximal end of the plug being projected from the end of the plug delivery sheath into the blood stream in the duct. In a further preferred embodiment, the wires could be designed to unfold upon both the proximal and the distal end of the plug.
- the proximal end of the plug is made from a thin layer of vascular graft prosthetic material such as polytetrafluoroethylene (PTFE), polyester or polyurethane with a wire or wireform (preferably made from shape-memory or self expanding material) internal the thin layer of vascular graft prosthetic material, such that when the plug is in place, the wire or wireform expands: thereby causing occlusion of the puncture.
- PTFE polytetrafluoroethylene
- the device is preferably deliverable to a puncture site through the introduction sheath that has already been inserted into the patient for the operation for which the puncture was formed in the first place. This has a distinct advantage over previous proposals for haemostasis devices where the original introduction sheath has had to be removed and a new sheath inserted into the puncture.
- the original guide wire can be reused to guide the device according to the present invention into place in the puncture.
- the device is preferably loaded into a plug delivery sheath that will slide into the existing delivery sheath but which is slightly longer than that sheath.
- the original sheath can be withdrawn.
- the plug is then preferably pushed down the plug delivery sheath until the enlargement at the proximal end of the plug projects from the end of the sheath. If the plug delivery sheath is then withdrawn gently from the wound, the enlargement will engage against the inside of the vessel wall and be pulled free of the proximal end of the plug delivery sheath.
- a pusher may be provided inside the plug delivery sheath to assist in the ejection of the plug from the end of the plug delivery sheath.
- stop means are provided on the plug delivery sheath or on the pusher such that initially they may be moved relative to one another by an amount just sufficient to project the enlargement of the plug beyond the end of the sheath. This feature prevents the plug from being fully deployed within the duct.
- the plug delivery sheath is introduced into the patient at an angle.
- the plug is designed to have, in its compressed state, a configuration that follows the angled plug delivery sheath. This ensures that the plug will be in the correct position, ie. in line with the puncture upon deployment of the plug from the delivery sheath.
- the plug includes a main body having a proximal end and a distal end of greater cross sectional area than the proximal end wherein upon expansion of the plug, the proximal end is positioned within the lumen of the vessel and the distal end within the tissue surrounding the vessel.
- the plug is funnel-like in shape.
- the plug is positioned within the puncture by means of a guidewire and a plug delivery sheath such that the free end of the guidewire extends into the lumen of the vessel.
- the guidewire has, disposed on its free end, a capture member which, upon withdrawal of the guidewire, abuts against the proximal end of the plug such that the proximal end of the plug is pulled internal the funnel-like structure of the plug thereby minimising the length of plug within the artery and therefore minimising obstruction of blood flow in the vessel.
- FIG. 1 shows a partly cut away perspective view of a plug for inclusion in a puncture occlusion device according to the present invention
- Figs. 2 to 7 show diagrammatically the stages in the placement of the plug of Fig. 1 in a puncture in a bodily duct using a device according to the present invention, each figure showing a longitudinal sectional view through the duct and the device;
- Figs. 8 to 12 show different embodiments of the invention as depicted in Fig. 1;
- Figs. 13a and 13b show a different embodiment of the invention as depicted in Fig. 1; and Fig. 14 shows an embodiment of the invention.
- the device according to the present invention includes a plug 10 as shown in Fig. 1.
- the plug 10 is formed of a polymer foam, polycarbonate foam or sponge material that has an expansion ratio of from about 1.5:1 to about 10:1.
- the plug 10 is formed with a circular flange 11 which is convex on its lower surface 12 (as seen in Fig.l) and substantially planar on its upper surface 13.
- An intermediate portion 14 is connected to the middle of the face 13. This intermediate portion 14 is circular in cross section and is of a diameter which is smaller than that of the flange 11 but sufficient that in its expanded condition it will occlude a puncture into which it is positioned in use.
- the upper end of the plug 10 comprises a substantially cylindrical body 15 which is of a greater diameter than the intermediate portion 14 but smaller than the flange 11.
- Three radially directed, spaced apart, circumferential ribs 16 are provided on the cylindrical surface of the cylindrical body 15.
- the convex lower surface 12 is coated with an anti-coagulant material.
- a puncture 26 made in an artery 17 in connection with an intraluminal procedure To position the plug 10 in a puncture 26 made in an artery 17 in connection with an intraluminal procedure the steps illustrated in Figs. 2 to 7 are followed.
- the puncture will normally have been made by the Seldinger needle technique in which a needle (not shown) is used to puncture the skin
- plug introducer sheath 22 is longer than the introducer sheath 18 so that the proximal end of plug introducer sheath 22 projects into the artery beyond the end of the introducer sheath 18 (see Fig. 3). With the plug introducer sheath 22 so positioned, the introducer sheath 18 can be withdrawn leaving the device 20 in place on the guidewire 19.
- the pusher tube 23 is formed with a pair of detents 24 projecting from each side adjacent its distal end.
- the pusher tube 23 is pushed inwardly relative to the plug introducer sheath 22 until the detents 24 abut against the distal end of the plug introducer sheath 22. This action will push the plug 10 out of the proximal end of the plug introducer sheath 22 until the flange 11 is free of the compressive force of the plug introducer sheath 22.
- the flange 11 will resiliently expand and project radially from the plug introducer sheath 22 (see Fig. 4).
- the device 20 is then carefully drawn distally until the flange 11 abuts against the inside surface of the artery 17 (see Fig. 5).
- the detents 24 are then depressed to allow the plug introducer sheath 22 to slide distally over the pusher tube 23. which is held stationary. This releases the remainder of the plug 10 from the compressive restraint of the plug introducer sheath 22 and the plug 10 is thus deployed in the puncture 26 (see Fig. 6).
- the intermediate portion 14 expands to occlude the puncture 26
- the flange 11 bears against the inside surface of the arterial wall and the cylindrical body 15 lies on the outer side of the arterial wall.
- the ribs 16 on the cylindrical body 15 serve to help retain the cylindrical body in place in the tissue surrounding the artery 17.
- the plug introducer sheath 22 and the guidewire 19 are then withdrawn and the procedure is completed (see Fig. 7).
- the plug 10 may be provided with reinforcing wires 31 to stiffen it and prevent it from being pulled through the puncture 26 in the artery wall 17.
- the wires 31 may be formed of Nitinol or another material that will change shape at the temperature of blood, or alternatively, a spring material. In this way. the wires could be designed to unfold like the ribs of an umbrella upon the proximal end 32 of the plug 10 being projected from the end of the plug introducer sheath 22 into the blood stream in the artery 17. The wires could also unfold upon both the proximal 32 and distal 33 ends of the plug 10 thus further reinforcing the plug 10 and preventing its dislodgment from the puncture 26.
- the wires 31 may be further adapted such that they project towards the wall of the artery 17 surrounding the puncture 26 thereby anchoring the plug 10 on both the intraluminal and endoluminal walls of the artery (as shown in Fig 9).
- the plug 10 may be adapted such that it does not extend into the artery 17 but instead is placed within the tissue directly adjacent the puncture 26 such that upon expansion of the plug 10. the puncture 26 is occluded (as shown in Fig. 10).
- the plug 10 of the present invention can be further anchored within the tissue surrounding the artery 17 by way of engagement members 34 which are disposed around the wall of the distal end 33 of the plug 10. and which extend into the tissue around the artery 17; thereby preventing the plug 10 from dislodging and entering the artery 17 through the puncture 26.
- the engagement members 34 can be made from Nitinol.
- the engagement members 34 take on an expanded configuration such that they extend outwardly from, and at an angle to, the wall of the distal end 33 of the plug 10.
- the proximal end 32 of the plug 10 is made from a thin layer of vascular graft material 30 such as PTFE, polyester with reinforcing wires 31 internal the thin layer of vascular graft material 30.
- the wire is preferably made from a shape memory or self expanding material.
- the plug 10 is adapted to take on an angled configuration in its compressed state such that it follows the angle of the plug introducer sheath 22, ensuring that the plug 10 will be in the correct position, ie. in line with the puncture 26. upon deployment of the plug 10 from the plug introducer sheath 22.
- the plug 10 is funnel-like in shape w ⁇ ith its distal end 33 greater in cross sectional area than its proximal end 32. Following placement of the plug 10 into the puncture 26. the free end 35 of the guidewire 19 is left in place within the artery 17.
- the guidewire 19 is adapted to have a capture member
- the guidewire 19 may be tied off. cut and withdrawn from the patient's body.
Abstract
Description
Claims
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AU64533/99A AU6453399A (en) | 1998-10-02 | 1999-10-01 | Device for the occlusion of a puncture in a bodily duct |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AUPP6337A AUPP633798A0 (en) | 1998-10-02 | 1998-10-02 | Device for the occlusion of a puncture in a bodily duct |
AUPP6337 | 1998-10-02 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2000019912A1 true WO2000019912A1 (en) | 2000-04-13 |
Family
ID=3810557
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/AU1999/000847 WO2000019912A1 (en) | 1998-10-02 | 1999-10-01 | Device for the occlusion of a puncture in a bodily duct |
Country Status (2)
Country | Link |
---|---|
AU (1) | AUPP633798A0 (en) |
WO (1) | WO2000019912A1 (en) |
Cited By (42)
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---|---|---|---|---|
WO2004058075A3 (en) * | 2002-12-20 | 2004-11-18 | Scimed Life Systems Inc | Closure device with textured surface |
WO2005051176A2 (en) | 2003-11-25 | 2005-06-09 | Boston Scientific Limited | Hemostatic pressure plug |
DE102004022780A1 (en) * | 2004-05-03 | 2005-12-01 | Michel DOARÉ | System for vascular occlusion, especially after arterial catheter intervention |
WO2006052612A1 (en) * | 2004-11-05 | 2006-05-18 | Accessclosure, Inc. | Apparatus for sealing a vascular puncture |
WO2007044510A1 (en) * | 2005-10-05 | 2007-04-19 | Loma Linda University Medical Center | Vascular wound closure device and method |
WO2007090150A2 (en) * | 2006-01-31 | 2007-08-09 | Cook Biotech Incorporated | Fistula grafts and related methods and systems for treating fistulae |
WO2007121747A1 (en) * | 2006-04-20 | 2007-11-01 | Cardio Capacity A/S | A vascular access closure device |
FR2908284A1 (en) | 2006-11-14 | 2008-05-16 | Protomed Sarl | OCCLUSION PLUG DELIVERY DEVICE. |
WO2007149989A3 (en) * | 2006-06-21 | 2008-09-25 | Cook Inc | Fistula grafts and related methods and systems useful for treating gastrointestinal fistulae |
US7648713B2 (en) | 1998-08-14 | 2010-01-19 | Incept Llc | Methods of using in situ hydration of hydrogel articles for sealing or augmentation of tissue or vessels |
US7780699B2 (en) | 2000-08-02 | 2010-08-24 | Loma Linda University Medical Center | Vascular wound closure device and method |
US7931628B2 (en) | 2000-02-24 | 2011-04-26 | Loma Linda University Medical Center | Device for closing tissue openings |
US8002742B2 (en) | 2005-04-22 | 2011-08-23 | Accessclosure, Inc. | Apparatus and methods for sealing a puncture in tissue |
US8012167B2 (en) | 2003-08-14 | 2011-09-06 | Loma Linda University Medical Center | Vascular wound closure device and method |
US8128654B2 (en) | 2003-06-04 | 2012-03-06 | Accessclosure, Inc. | Apparatus and methods for sealing a vascular puncture |
US8187627B2 (en) | 2003-09-05 | 2012-05-29 | Loma Linda University Medical Center | Dressing delivery system for internal wounds |
WO2012158738A1 (en) * | 2011-05-18 | 2012-11-22 | St. Jude Medical Puerto Rico Llc | Improved method and system for closing a vascular hole |
US8425552B2 (en) | 2000-08-02 | 2013-04-23 | Loma Linda University Medical Center | Apparatus for closing vascular puncture |
US8535349B2 (en) | 2007-07-02 | 2013-09-17 | Cook Biotech Incorporated | Fistula grafts having a deflectable graft body portion |
US8795709B2 (en) | 2006-03-29 | 2014-08-05 | Incept Llc | Superabsorbent, freeze dried hydrogels for medical applications |
WO2014123594A1 (en) * | 2013-02-06 | 2014-08-14 | St. Jude Medical Puerto Rico Llc | Extra-vascular closure device with releasable sealing plug |
US8852230B2 (en) | 2007-11-02 | 2014-10-07 | Incept Llc | Apparatus and methods for sealing a vascular puncture |
US8951283B2 (en) | 2004-11-05 | 2015-02-10 | Access Closure, Inc. | Apparatus and methods for sealing a vascular puncture |
WO2015020682A1 (en) * | 2013-08-07 | 2015-02-12 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Service | Transvascular and transcameral device access and closure |
US9113851B2 (en) | 2007-08-23 | 2015-08-25 | Cook Biotech Incorporated | Fistula plugs and apparatuses and methods for fistula plug delivery |
US9226736B2 (en) | 2005-04-29 | 2016-01-05 | Cook Biotech Incorporated | Volumetric grafts for treatment of fistulae and related methods and systems |
EP2967525A1 (en) * | 2013-03-11 | 2016-01-20 | St. Jude Medical Puerto Rico LLC | Active securement detachable sealing tip for extra-vascular closure device and methods |
US9289195B2 (en) | 2003-06-04 | 2016-03-22 | Access Closure, Inc. | Auto-retraction apparatus and methods for sealing a vascular puncture |
US9364206B2 (en) | 2008-04-04 | 2016-06-14 | Access Closure, Inc. | Apparatus and methods for sealing a vascular puncture |
US9386968B2 (en) | 2011-05-11 | 2016-07-12 | Access Closure, Inc. | Apparatus and methods for sealing a vascular puncture |
US9463004B2 (en) | 2009-05-04 | 2016-10-11 | Incept, Llc. | Biomaterials for track and puncture closure |
US9492149B2 (en) | 2007-11-13 | 2016-11-15 | Cook Biotech Incorporated | Fistula grafts and related methods and systems useful for treating gastrointestinal and other fistulae |
US9713462B2 (en) | 2008-11-12 | 2017-07-25 | Accessclosure, Inc. | Apparatus and methods for sealing a vascular puncture |
US9757105B2 (en) | 2012-03-23 | 2017-09-12 | Accessclosure, Inc. | Apparatus and methods for sealing a vascular puncture |
US9820728B2 (en) | 2011-01-19 | 2017-11-21 | Access Closure, Inc. | Apparatus and methods for sealing a vascular puncture |
US10143457B2 (en) | 2007-04-06 | 2018-12-04 | Cook Biotech Incorporated | Fistula plugs having increased column strength and fistula plug delivery apparatuses and methods |
US10182800B2 (en) | 2011-01-19 | 2019-01-22 | Access Closure, Inc. | Apparatus and methods for sealing a vascular puncture |
US10213191B2 (en) | 2006-09-13 | 2019-02-26 | Accessclosure, Inc. | Apparatus and methods for sealing a vascular puncture |
US10245012B2 (en) | 2012-03-23 | 2019-04-02 | Access Closure, Inc. | Apparatus and methods for sealing a vascular puncture |
US10595838B2 (en) | 2008-04-04 | 2020-03-24 | Accessclosure, Inc. | Apparatus and methods for sealing a vascular puncture |
CN110960285A (en) * | 2020-01-15 | 2020-04-07 | 付志刚 | Vascular sheath group with hemostasis function |
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US8105622B2 (en) | 1998-08-14 | 2012-01-31 | Incept Llc | Methods of using in situ hydration of hydrogel articles for sealing or augmentation of tissue or vessels |
US7780980B2 (en) | 1998-08-14 | 2010-08-24 | Incept, Llc | Methods of using in situ hydration of hydrogel articles for sealing or augmentation of tissue or vessels |
US7648713B2 (en) | 1998-08-14 | 2010-01-19 | Incept Llc | Methods of using in situ hydration of hydrogel articles for sealing or augmentation of tissue or vessels |
US7931628B2 (en) | 2000-02-24 | 2011-04-26 | Loma Linda University Medical Center | Device for closing tissue openings |
US8491628B2 (en) | 2000-08-01 | 2013-07-23 | Loma Linda University Medical Center | Vascular wound closure device and method |
US8702750B2 (en) | 2000-08-02 | 2014-04-22 | Loma Linda University | Apparatus for closing vascular puncture |
US9101731B2 (en) | 2000-08-02 | 2015-08-11 | Loma Linda University Medical Center | Vascular wound closure device and method |
US8425552B2 (en) | 2000-08-02 | 2013-04-23 | Loma Linda University Medical Center | Apparatus for closing vascular puncture |
US7780699B2 (en) | 2000-08-02 | 2010-08-24 | Loma Linda University Medical Center | Vascular wound closure device and method |
US9320505B2 (en) | 2000-08-02 | 2016-04-26 | Loma Linda University | Apparatus for closing vascular puncture |
JP2006515768A (en) * | 2002-12-20 | 2006-06-08 | ボストン サイエンティフィック サイムド, インコーポレイテッド | Closure device with textured surface |
WO2004058075A3 (en) * | 2002-12-20 | 2004-11-18 | Scimed Life Systems Inc | Closure device with textured surface |
US8398677B2 (en) | 2002-12-20 | 2013-03-19 | Boston Scientific Scimed, Inc. | Closure device with textured surface |
US9289195B2 (en) | 2003-06-04 | 2016-03-22 | Access Closure, Inc. | Auto-retraction apparatus and methods for sealing a vascular puncture |
US8128654B2 (en) | 2003-06-04 | 2012-03-06 | Accessclosure, Inc. | Apparatus and methods for sealing a vascular puncture |
US9364205B2 (en) | 2003-08-14 | 2016-06-14 | Loma Linda University Medical Center | Wound closure device and method |
US8012167B2 (en) | 2003-08-14 | 2011-09-06 | Loma Linda University Medical Center | Vascular wound closure device and method |
US8187627B2 (en) | 2003-09-05 | 2012-05-29 | Loma Linda University Medical Center | Dressing delivery system for internal wounds |
EP1689300A4 (en) * | 2003-11-25 | 2011-06-22 | Boston Scient Ltd An Irish Company | Hemostatic pressure plug |
EP1689300A2 (en) * | 2003-11-25 | 2006-08-16 | Boston Scientific Limited, an Irish company | Hemostatic pressure plug |
WO2005051176A2 (en) | 2003-11-25 | 2005-06-09 | Boston Scientific Limited | Hemostatic pressure plug |
DE102004022780A1 (en) * | 2004-05-03 | 2005-12-01 | Michel DOARÉ | System for vascular occlusion, especially after arterial catheter intervention |
US8951283B2 (en) | 2004-11-05 | 2015-02-10 | Access Closure, Inc. | Apparatus and methods for sealing a vascular puncture |
US9386969B2 (en) | 2004-11-05 | 2016-07-12 | Incept, Llc | Methods for sealing a vascular puncture |
US8986730B2 (en) | 2004-11-05 | 2015-03-24 | Incept, Llc | Methods for sealing a vascular puncture |
US9687216B2 (en) | 2004-11-05 | 2017-06-27 | Incept, Llc | Methods for sealing a vascular puncture |
US9039735B2 (en) | 2004-11-05 | 2015-05-26 | Access Closure, Inc. | Apparatus and methods for sealing a vascular puncture |
US10149670B2 (en) | 2004-11-05 | 2018-12-11 | Access Closure, Inc. | Apparatus and methods for sealing a vascular puncture |
WO2006052612A1 (en) * | 2004-11-05 | 2006-05-18 | Accessclosure, Inc. | Apparatus for sealing a vascular puncture |
US9107645B2 (en) | 2005-04-22 | 2015-08-18 | Access Closure, Inc. | Apparatus and methods for sealing a puncture in tissue |
US8002742B2 (en) | 2005-04-22 | 2011-08-23 | Accessclosure, Inc. | Apparatus and methods for sealing a puncture in tissue |
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