WO2000001307A9 - Absorbable polymers and surgical articles fabricated therefrom - Google Patents

Absorbable polymers and surgical articles fabricated therefrom

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Publication number
WO2000001307A9
WO2000001307A9 PCT/US1999/012683 US9912683W WO0001307A9 WO 2000001307 A9 WO2000001307 A9 WO 2000001307A9 US 9912683 W US9912683 W US 9912683W WO 0001307 A9 WO0001307 A9 WO 0001307A9
Authority
WO
WIPO (PCT)
Prior art keywords
suture
weight percent
monofilament
caprolactone
glycolide
Prior art date
Application number
PCT/US1999/012683
Other languages
French (fr)
Other versions
WO2000001307A1 (en
Inventor
Lydmilla K Kokish
Rooma M Mehta
Mark S Roby
Jerry K Jonn
Original Assignee
United States Surgical Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by United States Surgical Corp filed Critical United States Surgical Corp
Priority to CA002337133A priority Critical patent/CA2337133C/en
Priority to DE69943023T priority patent/DE69943023D1/en
Priority to AU44239/99A priority patent/AU4423999A/en
Priority to EP99927296A priority patent/EP1094755B1/en
Publication of WO2000001307A1 publication Critical patent/WO2000001307A1/en
Publication of WO2000001307A9 publication Critical patent/WO2000001307A9/en

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Classifications

    • DTEXTILES; PAPER
    • D01NATURAL OR MAN-MADE THREADS OR FIBRES; SPINNING
    • D01FCHEMICAL FEATURES IN THE MANUFACTURE OF ARTIFICIAL FILAMENTS, THREADS, FIBRES, BRISTLES OR RIBBONS; APPARATUS SPECIALLY ADAPTED FOR THE MANUFACTURE OF CARBON FILAMENTS
    • D01F6/00Monocomponent artificial filaments or the like of synthetic polymers; Manufacture thereof
    • D01F6/78Monocomponent artificial filaments or the like of synthetic polymers; Manufacture thereof from copolycondensation products
    • D01F6/84Monocomponent artificial filaments or the like of synthetic polymers; Manufacture thereof from copolycondensation products from copolyesters
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/22Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
    • A61L15/26Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L17/00Materials for surgical sutures or for ligaturing blood vessels ; Materials for prostheses or catheters
    • A61L17/06At least partially resorbable materials
    • A61L17/10At least partially resorbable materials containing macromolecular materials
    • A61L17/12Homopolymers or copolymers of glycolic acid or lactic acid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14Macromolecular materials
    • A61L27/18Macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/04Macromolecular materials
    • A61L31/041Mixtures of macromolecular compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/04Macromolecular materials
    • A61L31/06Macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/04Surgical instruments, devices or methods, e.g. tourniquets for suturing wounds; Holders or packages for needles or suture materials
    • A61B17/06Needles ; Sutures; Needle-suture combinations; Holders or packages for needles or suture materials
    • A61B17/06166Sutures
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/064Surgical staples, i.e. penetrating the tissue
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods, e.g. tourniquets
    • A61B2017/00004(bio)absorbable, (bio)resorbable, resorptive
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods, e.g. tourniquets
    • A61B2017/00526Methods of manufacturing
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B90/00Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges
    • A61B90/39Markers, e.g. radio-opaque or breast lesions markers
    • A61B2090/3937Visible markers

Definitions

  • Absorbable terpolymers of randomly polymerized glycolide, lactide and caprolactone are described. Processes for making the terpolymers and surgical articles made totally or in part from such terpolymers, including sutures, are also described.
  • Bioabsorbable surgical devices made from copolymers derived from glycolide and epsilon-caprolactone are known in the art. Such bioabsorbable surgical devices include surgical sutures .
  • a desirable characteristic of a bioabsorbable suture is its ability to exhibit and maintain desired tensile properties for a predetermined time period followed by rapid absorption of the suture mass (hereinafter "mass loss”.)
  • Absorbable multifiiament sutures such as DEXON II sutures (made from glycolide ho opolymer and commercially available from United States Surgical Corporation, North Haven, Connecticut) , VICRYL sutures (made from a copolymer of glycolide and lactide and commercially available from Ethicon, Inc., Sommerville, New Jersey) , and POLYSORB sutures (also made from a copolymer of glycolide and lactide and commercially available from United States Surgical Corporation, North Haven, Connecticut) are known in the industry as short term absorbable sutures.
  • DEXON II sutures made from glycolide ho opolymer and commercially available from United States Surgical Corporation, North Haven, Connecticut
  • VICRYL sutures made from a copolymer of glycolide and lactide and commercially available from Ethicon, Inc., Sommerville, New Jersey
  • POLYSORB sutures also made from a copolymer of glycolide and lactide and commercially available from United States
  • the classification short term absorbable sutures generally refers to surgical sutures which retain at least about 20 percent of their original strength at three weeks after implantation, with the suture mass being essentially absorbed in the body within about 60 to 90 days post implantation.
  • Long term absorbable sutures are generally classified as sutures capable of retaining at least about 20 percent of their original strength for six or more weeks after implantation, with the suture mass being essentially absorbed in the body within about 180 days post implantation.
  • PDS II sutures (commercially available from Ethicon, Inc., Sommerville, New Jersey) , are synthetic absorbable monofilament sutures that reportedly retain at least about 20 to 30 percent of its original strength six weeks after implantation.
  • PDS II reportedly exhibits minimal mass loss until 90 days after implantation with the suture mass being essentially absorbed in the body about 180 days after implantation.
  • MAXON suture (commercially available from United States Surgical Corporation, North Haven, Connecticut) is another absorbable synthetic monofilament that reportedly generally fits this absorption profile.
  • BIOSYN monofilament sutures which exhibit good flexibility, handling characteristics, knot strength and absorption characteristics similar to those of presently available short term absorbable multifilament sutures.
  • MONOCRYL a suture fabricated from an absorbable block copolymer containg glycolide and epsilon-caprolactone, commercially available from Ethicon, Inc.
  • gut suture refers to a collagen based suture of any type or origin often fabricated from the mammalian intestines, such as the serosal layer of bovine intestines or the submucosal fibrous layer of sheep intestines .
  • Gut sutures exhibit the unique combination of two week strength retention and about 75 day mass loss while maintaining acceptable modulus and tensile strength; and thus are still widely used in gynecological surgery.
  • U.S. Patent No. 4,700,704 to Jamiolkowski does teach that sutures can be fabricated from random copolymers of glycolide and epsilon-caprolactone, and more specifically from random copolymers containing from 20 to 35 weight percent epsilon-caprolactone and from 65 to 80 weight percent glycolide.
  • Jamiolkowski reports that sutures fabricated from glycolide/epsilon-caprolactone copolymers containing over 35% caprolactone are not orientable to a dimensionally stable fiber.
  • Jamiolkowski further reports that some sutures fabricated from glycolide/epsilon-caprolactone copolymers containing 15% caprolactone are also not orientable to a dimensionally stable fiber. Furthermore, Jamiolkowski also reports the undesirable combination of low modulus and low tensile strength for the glycolide/epsilon-caprolactone copolymers which he was able to fabricate into sutures .
  • U.S. Patents 4,045,418 and 4,057,537 disclose random copolymers obtained by copolymerizing lactide and epsilon- caprolactone as well as terpolymers obtained by polymerizing lactide, epsilon-caprolactone, and glycolide.
  • the copolymers as well as the terpolymers disclosed in U.S. Patents 4,045,418 and 4,057,537 have at least 60% by weight lactide.
  • absorbable surgical articles formed from a random terpolymer of glycolide caprolactone and lactide exhibit strength retention, mass loss and modulus similar to that of gut sutures.
  • the terpolymers used in forming surgical articles include between about 14 and about 17 weight percent of units derived from caprolactone, between about 70 and 76 weight percent of units derived from glycolide, and between about 9 to about 15 weight percent of units derived from lactide.
  • the random terpolymers can be spun into fibers .
  • the fibers can be advantageously fabricated into either monofilament or multifilament sutures having physical properties similar to those of gut sutures .
  • the process comprises the operations of extruding the random caprolactone/ glycolide / lactide copolymer at an extrusion temperature of from about 130°C to about 190°C to provide a monofilament fiber, passing the solidified monofilament through water (or other suitable liquid medium) quench bath at a temperature of from about 15° C to about 28° C or through in air (or other suitable gaseous medium) at from about 15°C to about 30°C, stretching the monofilament through a series of air ovens at an overall stretch ratio of from about 6:1 to about 13 : 1 to provide a stretched monofilament.
  • the monofilament is stretched through three air ovens by four godet stations.
  • the first air oven is maintained at ambient temperature, whereas the second air oven is heated to a temperature above the crystalization temperature of the glycolide/lactide/epsilon-caprolactone copolymer at about 80°C to about 115°C
  • the third air oven is set at about 80°C to about 125°C.
  • the draw ratio between the first and second godet station ranges between about 5:1 to about 12:1.
  • the draw ratio between the second and third godet station ranges between about 1.1:1 to about 2.6:1.
  • the draw ratio between the third and fourth godet station ranges between about 0.75:1 to about 1.05:1.
  • the suture then may be annealed with or without relaxation at a temperature of from about 80°C to about 125°C to provide the finished suture.
  • Fig. 1A is a schematic illustration of an apparatus which is suitable for manufacturing of monofilament sutures disclosed herein;
  • Fig. IB is a modificatiuon of the apparatus shown in Fig. 1A which is particularily suitable for manufacturing monfilament sutures of smaller size; e.g. sizes 4/0 and smaller .
  • Fig. 2 is a perspective view of a suture attached to a needle.
  • Fig. 3A - 3C illustrate the formation of the knot which was employed in the loop pull test used in Table IV.
  • glycolide, epsilon-caprolactone, and lactide monomers can advantageously be combined to form a random polymer useful in forming surgical articles having strength retention, mass loss, and modulus characteristics similar to or superior to gut sutures .
  • the random polymer can be prepared using conventional techniques. For example, monomers can be dried, mixed in a reaction vessel with an initiator (either a single or multifunctional initiator) and a suitable polymerization catalyst and polymerized at temperatures from about 170 * C to about 200 * C for a period of time ranging from about 10 hours to about 30 hours.
  • an initiator either a single or multifunctional initiator
  • a suitable polymerization catalyst and polymerized at temperatures from about 170 * C to about 200 * C for a period of time ranging from about 10 hours to about 30 hours.
  • the polymer has randomly combined repeating units derived from glycolide, lactide and epsilon-caprolactone. Repeating units derived from glycolide comprise between about 70 and about 76 weight percent of the polymer, while repeating units derived from lactide comprise about 9 to about 15 weight percent of the polymer and units derived from caprolactone comprise about 14 to about 17 weight percent of polymer. Polymers of caprolactone, glycolide, and lactide having an inherent viscosity of from about 0.9 to about 1.8 dl/g measured at 30 'C and at a concentration of 0.25 g/dl in chloroform or HFIP may generally be used.
  • the random polymers provided herein can be blended or copolymerized with other known absorbable polymers and/or coploymers derived from materials such as glycolide, lactide, caprolactone, dioxanone, trimethylene carbonate, alkylene oxides, absorbable amides and the like. It should be understood that the above list of materials with which the random copolymer can be either blended or copolymerized is provided for illustrative purposes and is not to be construed as limiting.
  • the random polymers can be formed into surgical articles using any known technique, such as, for example, extrusion, molding and/or solvent casting.
  • the copolymers can be used alone, blended with other absorbable compositions, or in combination with non-absorbable components .
  • a wide variety of surgical articles can be manufactured from the copolymers described herein. These include but are not limited to clips and other fasteners, staples, sutures, pins, screws, prosthetic devices, wound dressings, drug delivery devices, anastomosis rings , and other implantable devices .
  • Fibers made from the copolymers can be knitted, woven or made into non-woven materials with other fibers, either absorbable or nonabsorbable to form fabrics, such as meshes and felts. Compositions including these random copolymers can also be used as an absorbable coating for surgical devices. Preferably, however, the polymers are spun into fibers to be used in making sutures .
  • Multifilament sutures of the present invention may be made by methods known in the art. Braid constructions such as those disclosed and claimed in U.S. Patent No.'s 5,059,213 and 5,019,093 are suitable for the multifilament suture of the present invention.
  • Fig. 1A substantially illustrates the extruding, quenching and stretching operations of the monofilament manufacturing operation herein.
  • Extruder unit 10 is of a known or conventional type and is equipped with controls for regulating the temperature of barrel 11 in various zones thereof, e.g., progressively higher temperatures in three consecutive zones A, B and C along the length of the barrel.
  • Pellets or powder of resins of the present invention are introduced to the extruder through hopper 12. Any of the above described polymers which are useful for the formation of fibers can be used herein.
  • Motor-driven metering pump 13 delivers melt extruded resin at a constant rate to spin pack 14 and thereafter through spinneret 15 possessing one or more orifices of desired diameter to provide a molten monofilament 16 which then enters quench bath 17, e.g., containing water, where the monofilament solidifies.
  • the distance monofilament 16 travels after emerging from spinneret 15 to the point where it enters quench bath 17, i.e., the air gap, can vary and can advantageously be from about 0.5 to about 100 cm and preferably from about 1 to about 20 cm.
  • barrel zone A of the extruder can be maintained at a temperature of from about 130°C to 180°C, zone B at from about 135°C to 190°C and zone C at from about 135°C to about 190°C. Additional temperature parameters include: metering pump block 13 at from about 135°C to about 190°C, spinneret 15 at from about 140°C to about 190°C and quench bath at from about 15°C to about 25°C.
  • Monofilament 16 is passed through quench bath 17 around driven roller 18 and over idle roller 19.
  • a wiper may remove excess water from the monofilament as it is removed from quench bath 17.
  • the monofilament is passed through first godet station 1, which is equiped with five individual godets, i.e. godets 101,
  • godet station 2 containing godets 106, 107, 108, 109, and 110, where it is wrapped over godet 106, under godet 107, over godet 108, under godet 109, and over godet 110.
  • Monofilament 16 passing from godet station 1 to godet station 2 is drawn through air oven 23 at a temperature ranging form about 25°C to about 40°C by the godets of godet station 2 which rotate at speeds faster than the speed of the godet station 1 to provide the desired draw ratio, which is from about 5:1 to about 12:1 and preferably from about 6:1 to about 10:1, to effect the molecular orientation of the copolymer from which it is fabricated and thereby increase its tensile strength.
  • monofilament 16 is then subjected to a second and a third drawing operation.
  • Monofilament 16 is subsequently drawn from godet 110 through air oven 24, which is maintained at from about 80°C to about 115°C, to godet station 3 containing godets 111, 112, 113, 114, and 115 where it is wrapped over godet 111, under godet 112, over godet 113, under godet 114, and over godet 115.
  • Godet station 3 spins faster than godet station 2 to provide the desired draw ratio, which is from about 1.3:1 to about 2.6:1.
  • Monofilament 16 is then drawn from godet 115 through air oven 25, which is maintained at from about 80°C to about 125°C, by godet station 4, containing godets 116, 117 118, 119, and 120 where it is wrapped over godet 116, under godet 117, over godet 118, under godet 119, and over godet 120.
  • Godet station 4 spins faster than godet station 3 to provide the desired draw ratio, which is from about 0.75:1 to about 1.05:1. It should be understood that the godet arrangements in each of godet stations 1, 2, 3, and 4 , respectively should not be limited to the above described arrangement and that each godet station may have any suitable godet arrangement .
  • the suture After a suitable period of residency in the heating cabinet, e.g., for up to about 18 hours or so, the suture will have undergone essentially no shrinkage.
  • the creel may be rotated within the heating cabinet in order to insure uniform heating of the monofilament or the cabinet may be of the circulating hot air type in which case uniform heating of the monofilament will be achieved without the need to rotate the creel.
  • the creel with its annealed suture is removed from the heating cabinet and when returned to room temperature, the suture is removed from the creel, conveniently by cutting the wound monofilament at opposite ends of the creel.
  • the annealed sutures optionally attached to surgical needles, are then ready to be packaged and sterilized.
  • the suture may be annealed on line with or without relaxation.
  • the fourth godet station rotates at a slower speed than the third godet station thus relieving tension on the filament .
  • suture 101 may be attached to a surgical needle 100 as shown in Fig. 2 by methods well known in the art. Wounds may be sutured by passing the needled suture through tissue to create wound closure. The needle preferably is then removed from the suture and the suture tied.
  • the suture can carry a therapeutic agent which will be deposited at the repair site.
  • the therapeutic agent can be chosen for its antimicrobial properties, capability for promoting repair or reconstruction and/or new tissue growth.
  • Antimicrobial agents such as broad spectrum antibiotic (gentamycin sulfate, erythromycin or derivatized glycopeptides) which are slowly released into the tissue can be applied in this manner to aid in combating clinical and sub-clinical infections in a tissue repair site.
  • one or several growth promoting factors can be introduced into the sutures, e.g., fibroblast growth factor, bone growth factor, epidermal growth factor, platelet derived growth factor, macrophage derived growth factor, alveolar derived growth factor, monocyte derived growth factor, magainin, and so forth.
  • Some therapeutic indications are: glycerol with tissue or kidney plasminogen activator to cause thrombosis, superoxide dimutase to scavenge tissue damaging free radicals, tumor necrosis factor for cancer therapy or colony stimulating factor and interferon, interleukin-2 or other lymphokine to enhance the immune system.
  • sutures in order to increase visibility of the suture in the surgical field.
  • Dyes known to be suitable for incorporation in sutures can be used. Such dyes include but are not limited to carbon black, bone black, D&C Green No. 6, and D&C Violet No. 2 as described in the handbook of U.S. Colorants for Food, Drugs and Cosmetics by Daniel M. Marrion (1979) .
  • sutures in accordance with the invention are dyed by adding up to about a few percent and preferably about 0.2% dye, such as D&C Violet No. 2 to the resin prior to extrusion, although addition of the dye during polymerization is also suitable.
  • Dry glycolide (1320 grams) , dry 1-lactide (300 grams) , and distilled epsilon-caprolactone (380 grams) were added to a reactor along with 0.24 grams of distilled stannous octoate and 0.2 grams of distilled diethylene glycol (DEG) .
  • the mixture was dried for about 21 hours and 40 minutes with agitation under flow of nitrogen.
  • the reactor temperature was then set at 100 "C. When the temperature of the reaction vessel reached 100 "C, the temperature was maintained for about 15 minutes. Then the temperature of the reaction vessel was raised to 150 “C and then the reaction vessel heated for about an additional 15 minutes . The temperature of the reaction was then raised to about 190 "C and polymerization conducted with stirring under a nitrogen atmosphere for about 25 hours and 40 minutes.
  • reaction product is then isolated, comminuted, and treated to remove residual reactants using known techniques.
  • the treatment to remove residual reactants occurs at 100 "C for 48 hours under vacuum.
  • NMR analysis using a commercially available Bruker NMR, model number DPX-300, revealed the resultant polymer contained 12.9 weight percent lactide, 16.6 weight percent caprolactone, and 70.5 weight percent glycolide.
  • EXAMPLE 2 Dry glycolide (4080 grams) , dry 1-lactide (900 grams) , and distilled epsilon-caprolactone (1020 grams) were added to a reactor along with 0.72 grams of distilled stannous octoate and 1.2 grams of distilled diethylene glycol (DEG) . The mixture was dried for about 18.75 hours with agitation under flow of nitrogen. The reactor temperature was then set at 100 "C. When the temperature of the reaction vessel reached 100 "C, the temperature was maintained for about 15 minutes . Then the temperature of the reaction vessel was raised to 150 * C and then the reaction vessel heated for about an additional 15 minutes. The temperature of the reaction vessel was then raised to about 190 * C and polymerization conducted with stirring under a nitrogen atmosphere for about 23 hours and 10 minutes.
  • DEG diethylene glycol
  • reaction product is then isolated, comminuted, and treated to remove residual reactants using known techniques.
  • the treatment to remove residual reactants occurs at 90 'C for 48 hours under vaccuum.
  • NMR analysis using a commercially available Bruker NMR, model number DPX-300, revealed the resultant polymer contained 12.5 weight percent lactide, 15.3 weight percent caprolactone, and 72.2 weight percent glycolide.
  • Dry glycolide (3960 grams) , dry 1-lactide (1020 grams) , and distilled epsilon-caprolactone (1020 grams) were added to a reactor along with 0.72 grams of distilled stannous octoate and 0.6 grams of distilled diethylene glycol (DEG).
  • the mixture was dried for about 10 hours with agitation under flow of nitrogen.
  • the reactor temperature was then set at 100 * C. When the temperature of the reaction vessel reached 100 * C, the temperature was maintained for about 15 minutes. Then the temperature of the reaction vessel was raised to 150 "C and the reaction vessel heated for about an additional 15 minutes . The temperature of the reactants was then raised to about 190 'C and polymerization conducted with stirring under a nitrogen atmosphere for about 22 hours and 35 minutes.
  • reaction product is then isolated, comminuted, and treated to remove residual reactants using known techniques.
  • the treatment to remove residual reactants occurs at 90 * C for 48 hours under vacuum.
  • NMR analysis using a commercially available Bruker NMR, model number DPX-300, revealed the resultant polymer contained 14.5 weight percent lactide, 14.9 weight percent caprolactone, and 70.6 weight percent glycolide.
  • Dry glycolide (4200 grams) , dry 1-lactide (780 grams) , and distilled epsilon-caprolactone (1020 grams) were added to a reactor along with 0.72 grams of distilled stannous octoate and 0.6 grams of distilled diethylene glycol (DEG) .
  • the mixture was dried for about 5.75 hours with agitation under flow of nitrogen.
  • the reactor temperature was then set at 100 * C. When the temperature of the reaction vessel reached 100 * C the temperature was maintained for about 15 minutes . Then the temperature of the reaction vessel was raised to about 150 °C and then the reaction vessel heated for about an additional 15 minutes . The temperature of the reaction vessel was then raised to about 190 * C and polymerization conducted with stirring under a nitrogen atmosphere for about 23 hours and 15 minutes.
  • the reaction product is then isolated, comminuted, and treated to remove residual reactants using known techniques.
  • the treatment to remove residual reactants occurs at 90 "C for 48 hours under vacuum.
  • NMR analysis using a commercially available Bruker NMR, model number DPX-300, revealed the resultant polymer contained 11.2 weight percent lactide, 14.2 weight percent caprolactone, and 74.6 weight percent glycolide. Table I below sets forth typical conditions for extruding, stretching of size 3/0 sutures. All of the monofilament sutures were fabricated from the resins of Examples 1 - 4, respectively.
  • Example 1 2 3 4 annealing temp., °C 105 110 100 110 time (hrs . ) 6 6 6 6
  • Table III sets forth the physical properties of the size 3/0 suture of the present invention.
  • Example 1 Example 2
  • Example 3 Example 4 diameter (mm) .324 0.316 .319 .319 knot-pull strength (kg) 2.64 2.51 2.29 2.99
  • Young's Modulus (kpsi) 380 661 523 734 Elongation % 38 19 27 29
  • the suture made of the copolymer provided herein shows a desired physical properties, such as modulus and tensile strength.
  • the suture samples were stored in a container filled with Sorenson's buffer solution at 37 "C. After various periods of time, the suture samples were then removed from the container to test their loop-pull strength as follows.
  • a knotted loop was formed. in a test suture in three steps as shown in FIGS. 3A - 3C. As shown in step 1 of FIG 3A , each suture was given a double throw (left over right ) around a 2 cm diameter cylinder. In Step 2, the free ends of the suture were set in a single throw (right over left) onto the initial throw of step 1. Finally, in step 3, another double throw ( left over right) was set onto the single throw of Step 2 to complete the knot. The free ends of the suture were cut to approximately 0.5 inches and the loop was carefully eased from the cylinder.
  • T n represents the time elapsed in weeks since the sample was placed in the solution, with n representing the number of weeks .
  • the suture samples were weighed and stored in a fritted microencapsulation thimble (commercially available from Chemglass, Inc., Vineland, New Jersey) , which was placed in a scintillation vial filled with Sorenson's buffer solution. The scintillation vials were then pOlaced in a water bath at 80 "C. After various periods of time, the microextraction thimbles containing the suture samples were then removed from the scintillation vial, vacuum filtered, rinsed with distilled water, vacuum filtered, and dried for about 6 hours at about 40 "C under vacuum and subsequently the suture and thimble were weighed.
  • a fritted microencapsulation thimble commercially available from Chemglass, Inc., Vineland, New Jersey
  • the weight of the suture remaining was calculated by substracting the weight of the thimble from the weight of the thimble containing the remaining suture.
  • the percentage of the suture retained was calculated by dividing the weight of the remaining suture by the original weight of the suture and multiplying the result by 100.
  • T n represents the time elapsed in hours since the sample was placed in the solution, with n representing the number of hours . It is well known in the art that one hour of immersion in the container filled with Sorenson's buffer solution at 80 "C approximates about one day of invivo mass loss. For comparison purposes, the same tests were conducted on Monocryl sutures . All comparative tests were performed on size 3/0 sutures. T ABLE V

Abstract

Synthetic absorbable medical devices made totally or in part from a random polymer comprising glycol, lactic, and caproic, are provided. The polymer can be fabricated into a monofilament (16) which exhibits physical characteristics equivalent to or superior than gut suture.

Description

ABSORBABLE POLYMERS AND SURGICAL ARTICLES FABRICATED THEREFROM
TECHNICAL FIELD
Absorbable terpolymers of randomly polymerized glycolide, lactide and caprolactone are described. Processes for making the terpolymers and surgical articles made totally or in part from such terpolymers, including sutures, are also described.
BACKGROUND
Bioabsorbable surgical devices made from copolymers derived from glycolide and epsilon-caprolactone are known in the art. Such bioabsorbable surgical devices include surgical sutures .
A desirable characteristic of a bioabsorbable suture is its ability to exhibit and maintain desired tensile properties for a predetermined time period followed by rapid absorption of the suture mass (hereinafter "mass loss".)
Synthetic absorbable sutures are known in the art. Absorbable multifiiament sutures such as DEXON II sutures (made from glycolide ho opolymer and commercially available from United States Surgical Corporation, North Haven, Connecticut) , VICRYL sutures (made from a copolymer of glycolide and lactide and commercially available from Ethicon, Inc., Sommerville, New Jersey) , and POLYSORB sutures (also made from a copolymer of glycolide and lactide and commercially available from United States Surgical Corporation, North Haven, Connecticut) are known in the industry as short term absorbable sutures. The classification short term absorbable sutures generally refers to surgical sutures which retain at least about 20 percent of their original strength at three weeks after implantation, with the suture mass being essentially absorbed in the body within about 60 to 90 days post implantation. Long term absorbable sutures are generally classified as sutures capable of retaining at least about 20 percent of their original strength for six or more weeks after implantation, with the suture mass being essentially absorbed in the body within about 180 days post implantation. For example, PDS II sutures (commercially available from Ethicon, Inc., Sommerville, New Jersey) , are synthetic absorbable monofilament sutures that reportedly retain at least about 20 to 30 percent of its original strength six weeks after implantation. However, PDS II reportedly exhibits minimal mass loss until 90 days after implantation with the suture mass being essentially absorbed in the body about 180 days after implantation. MAXON suture (commercially available from United States Surgical Corporation, North Haven, Connecticut) is another absorbable synthetic monofilament that reportedly generally fits this absorption profile.
Most recently, United States Surgical Corporation has introduced BIOSYN monofilament sutures which exhibit good flexibility, handling characteristics, knot strength and absorption characteristics similar to those of presently available short term absorbable multifilament sutures.
Another attempt to provide an acceptable synthetic absorbable monofilament sutures resulted in MONOCRYL, a suture fabricated from an absorbable block copolymer containg glycolide and epsilon-caprolactone, commercially available from Ethicon, Inc.
However, no synthetic absorbable monofilament sutures exist today which approximate the strength retention, mass loss, and modulus of sutures commonly referred to in the art as "catgut" or "gut" sutures. It is well known in the art that the term gut suture refers to a collagen based suture of any type or origin often fabricated from the mammalian intestines, such as the serosal layer of bovine intestines or the submucosal fibrous layer of sheep intestines . Gut sutures exhibit the unique combination of two week strength retention and about 75 day mass loss while maintaining acceptable modulus and tensile strength; and thus are still widely used in gynecological surgery.
It would be advantageous to provide a synthetic absorbable suture which exhibits physical properties similar to the gut suture.
U.S. Patent No. 4,700,704 to Jamiolkowski does teach that sutures can be fabricated from random copolymers of glycolide and epsilon-caprolactone, and more specifically from random copolymers containing from 20 to 35 weight percent epsilon-caprolactone and from 65 to 80 weight percent glycolide. Moreover, Jamiolkowski reports that sutures fabricated from glycolide/epsilon-caprolactone copolymers containing over 35% caprolactone are not orientable to a dimensionally stable fiber. Jamiolkowski further reports that some sutures fabricated from glycolide/epsilon-caprolactone copolymers containing 15% caprolactone are also not orientable to a dimensionally stable fiber. Furthermore, Jamiolkowski also reports the undesirable combination of low modulus and low tensile strength for the glycolide/epsilon-caprolactone copolymers which he was able to fabricate into sutures .
U.S. Patents 4,045,418 and 4,057,537 disclose random copolymers obtained by copolymerizing lactide and epsilon- caprolactone as well as terpolymers obtained by polymerizing lactide, epsilon-caprolactone, and glycolide. The copolymers as well as the terpolymers disclosed in U.S. Patents 4,045,418 and 4,057,537 have at least 60% by weight lactide. These copolymers have been described in the literature as having "one major drawback which has prevented their wide spread use. Although the copolymers can be literally interpreted to be 'bioabsorbable' , the rate of absorption is so slow that it renders the copolymers practically useless for numerous medical applications" (see U.S. Patent 5,468,253 at column 2, lines 24 et seq.). In fact, U.S. Patent 5,468,253 addresses this problem by disclosing medical devices formed from a random copolymer of: a) from about 30 to about 50 weight percent of epsilon- caprolactone, trimethylene carbonate, an ether lactone and combinations thereof, and b) the balance being substantially glycolide or para-dioxanone .
Therefore, it would be unexpected that medical devices such as sutures made from random copolymer of glycolide, epsilon-caprolactone, and lactide would provide the strength retention and mass loss characteristics approximating those of gut sutures while maintaining an acceptable modulus and tensile strength.
SUMMARY
It has now surprisingly been found that absorbable surgical articles formed from a random terpolymer of glycolide caprolactone and lactide exhibit strength retention, mass loss and modulus similar to that of gut sutures. Preferably, the terpolymers used in forming surgical articles include between about 14 and about 17 weight percent of units derived from caprolactone, between about 70 and 76 weight percent of units derived from glycolide, and between about 9 to about 15 weight percent of units derived from lactide.
In particularly useful embodiments, the random terpolymers can be spun into fibers . The fibers can be advantageously fabricated into either monofilament or multifilament sutures having physical properties similar to those of gut sutures .
In addition, a process of making such synthetic absorbable monofilament sutures from the above described caprolactone/glycolide/lactide random terpolymers has been found. The process, for a given size suture, comprises the operations of extruding the random caprolactone/ glycolide / lactide copolymer at an extrusion temperature of from about 130°C to about 190°C to provide a monofilament fiber, passing the solidified monofilament through water (or other suitable liquid medium) quench bath at a temperature of from about 15° C to about 28° C or through in air (or other suitable gaseous medium) at from about 15°C to about 30°C, stretching the monofilament through a series of air ovens at an overall stretch ratio of from about 6:1 to about 13 : 1 to provide a stretched monofilament. In a particularly useful embodiment, the monofilament is stretched through three air ovens by four godet stations. The first air oven is maintained at ambient temperature, whereas the second air oven is heated to a temperature above the crystalization temperature of the glycolide/lactide/epsilon-caprolactone copolymer at about 80°C to about 115°C , and the third air oven is set at about 80°C to about 125°C. The draw ratio between the first and second godet station ranges between about 5:1 to about 12:1. The draw ratio between the second and third godet station ranges between about 1.1:1 to about 2.6:1. The draw ratio between the third and fourth godet station ranges between about 0.75:1 to about 1.05:1. The suture then may be annealed with or without relaxation at a temperature of from about 80°C to about 125°C to provide the finished suture.
BRIEF DESCRIPTION OF THE DRAWINGS
Fig. 1A is a schematic illustration of an apparatus which is suitable for manufacturing of monofilament sutures disclosed herein;
Fig. IB is a modificatiuon of the apparatus shown in Fig. 1A which is particularily suitable for manufacturing monfilament sutures of smaller size; e.g. sizes 4/0 and smaller . Fig. 2 is a perspective view of a suture attached to a needle.
Fig. 3A - 3C illustrate the formation of the knot which was employed in the loop pull test used in Table IV.
DESCRIPTION OF THE PREFERRED EMBODIMENTS
It has been found that glycolide, epsilon-caprolactone, and lactide monomers can advantageously be combined to form a random polymer useful in forming surgical articles having strength retention, mass loss, and modulus characteristics similar to or superior to gut sutures .
The random polymer can be prepared using conventional techniques. For example, monomers can be dried, mixed in a reaction vessel with an initiator (either a single or multifunctional initiator) and a suitable polymerization catalyst and polymerized at temperatures from about 170 *C to about 200 *C for a period of time ranging from about 10 hours to about 30 hours.
The polymer has randomly combined repeating units derived from glycolide, lactide and epsilon-caprolactone. Repeating units derived from glycolide comprise between about 70 and about 76 weight percent of the polymer, while repeating units derived from lactide comprise about 9 to about 15 weight percent of the polymer and units derived from caprolactone comprise about 14 to about 17 weight percent of polymer. Polymers of caprolactone, glycolide, and lactide having an inherent viscosity of from about 0.9 to about 1.8 dl/g measured at 30 'C and at a concentration of 0.25 g/dl in chloroform or HFIP may generally be used.
The random polymers provided herein can be blended or copolymerized with other known absorbable polymers and/or coploymers derived from materials such as glycolide, lactide, caprolactone, dioxanone, trimethylene carbonate, alkylene oxides, absorbable amides and the like. It should be understood that the above list of materials with which the random copolymer can be either blended or copolymerized is provided for illustrative purposes and is not to be construed as limiting.
The random polymers can be formed into surgical articles using any known technique, such as, for example, extrusion, molding and/or solvent casting. The copolymers can be used alone, blended with other absorbable compositions, or in combination with non-absorbable components . A wide variety of surgical articles can be manufactured from the copolymers described herein. These include but are not limited to clips and other fasteners, staples, sutures, pins, screws, prosthetic devices, wound dressings, drug delivery devices, anastomosis rings , and other implantable devices . Fibers made from the copolymers can be knitted, woven or made into non-woven materials with other fibers, either absorbable or nonabsorbable to form fabrics, such as meshes and felts. Compositions including these random copolymers can also be used as an absorbable coating for surgical devices. Preferably, however, the polymers are spun into fibers to be used in making sutures .
Multifilament sutures of the present invention may be made by methods known in the art. Braid constructions such as those disclosed and claimed in U.S. Patent No.'s 5,059,213 and 5,019,093 are suitable for the multifilament suture of the present invention.
Fig. 1A substantially illustrates the extruding, quenching and stretching operations of the monofilament manufacturing operation herein. Extruder unit 10 is of a known or conventional type and is equipped with controls for regulating the temperature of barrel 11 in various zones thereof, e.g., progressively higher temperatures in three consecutive zones A, B and C along the length of the barrel. Pellets or powder of resins of the present invention are introduced to the extruder through hopper 12. Any of the above described polymers which are useful for the formation of fibers can be used herein.
Motor-driven metering pump 13 delivers melt extruded resin at a constant rate to spin pack 14 and thereafter through spinneret 15 possessing one or more orifices of desired diameter to provide a molten monofilament 16 which then enters quench bath 17, e.g., containing water, where the monofilament solidifies. The distance monofilament 16 travels after emerging from spinneret 15 to the point where it enters quench bath 17, i.e., the air gap, can vary and can advantageously be from about 0.5 to about 100 cm and preferably from about 1 to about 20 cm. If desired, a chimney (not shown) , or shield, can be provided to isolate monofilament 16 from contact with air currents which might otherwise affect the cooling of the monofilament in an unpredictable manner. In general, barrel zone A of the extruder can be maintained at a temperature of from about 130°C to 180°C, zone B at from about 135°C to 190°C and zone C at from about 135°C to about 190°C. Additional temperature parameters include: metering pump block 13 at from about 135°C to about 190°C, spinneret 15 at from about 140°C to about 190°C and quench bath at from about 15°C to about 25°C.
Monofilament 16 is passed through quench bath 17 around driven roller 18 and over idle roller 19. Optionally, a wiper (not shown) may remove excess water from the monofilament as it is removed from quench bath 17. On exiting the quench bath the monofilament is passed through first godet station 1, which is equiped with five individual godets, i.e. godets 101,
102, 103, 104 and 105. Upon entering godet station 1, monofilament 16 is wrapped around a first godet 101 provided with nip roll 22 to prevent slippage which might otherwise result from the subsequent stretching operation; and subsequently passed over godet 101, under godet 102, over godet
103, under godet 104, and over godet 105 to godet station 2, containing godets 106, 107, 108, 109, and 110, where it is wrapped over godet 106, under godet 107, over godet 108, under godet 109, and over godet 110. Monofilament 16 passing from godet station 1 to godet station 2 is drawn through air oven 23 at a temperature ranging form about 25°C to about 40°C by the godets of godet station 2 which rotate at speeds faster than the speed of the godet station 1 to provide the desired draw ratio, which is from about 5:1 to about 12:1 and preferably from about 6:1 to about 10:1, to effect the molecular orientation of the copolymer from which it is fabricated and thereby increase its tensile strength.
Following the initial draw at about 20°C to about 40°C temperature, monofilament 16 is then subjected to a second and a third drawing operation. Monofilament 16 is subsequently drawn from godet 110 through air oven 24, which is maintained at from about 80°C to about 115°C, to godet station 3 containing godets 111, 112, 113, 114, and 115 where it is wrapped over godet 111, under godet 112, over godet 113, under godet 114, and over godet 115. Godet station 3 spins faster than godet station 2 to provide the desired draw ratio, which is from about 1.3:1 to about 2.6:1. Monofilament 16 is then drawn from godet 115 through air oven 25, which is maintained at from about 80°C to about 125°C, by godet station 4, containing godets 116, 117 118, 119, and 120 where it is wrapped over godet 116, under godet 117, over godet 118, under godet 119, and over godet 120. Godet station 4 spins faster than godet station 3 to provide the desired draw ratio, which is from about 0.75:1 to about 1.05:1. It should be understood that the godet arrangements in each of godet stations 1, 2, 3, and 4 , respectively should not be limited to the above described arrangement and that each godet station may have any suitable godet arrangement .
In an alternative operation for sutures for smaller size sutures, e.g. sizes 4/0 to 8/0, as show in Fig. IB monofilament 16 is only passed through godet stations 1 and 2 and not subjected to any further stetching operations. Annealing of the suture also may be accomplished with or without shrinkage of the suture. In carrying out the annealing operation, the desired length of suture may be wound around a creel and the creel placed in a heating cabinet under nitrogen flow maintained at the desired temperature, e.g. about 80 'C to about 125 *C, as described in U.S. Patent No. 3,630,205. After a suitable period of residency in the heating cabinet, e.g., for up to about 18 hours or so, the suture will have undergone essentially no shrinkage. As shown in U.S. Patent No. 3,630,205, the creel may be rotated within the heating cabinet in order to insure uniform heating of the monofilament or the cabinet may be of the circulating hot air type in which case uniform heating of the monofilament will be achieved without the need to rotate the creel. Thereafter, the creel with its annealed suture is removed from the heating cabinet and when returned to room temperature, the suture is removed from the creel, conveniently by cutting the wound monofilament at opposite ends of the creel. The annealed sutures, optionally attached to surgical needles, are then ready to be packaged and sterilized.
Alternatively, the suture may be annealed on line with or without relaxation. For relaxation, the fourth godet station rotates at a slower speed than the third godet station thus relieving tension on the filament .
The suture disclosed herein, suture 101, may be attached to a surgical needle 100 as shown in Fig. 2 by methods well known in the art. Wounds may be sutured by passing the needled suture through tissue to create wound closure. The needle preferably is then removed from the suture and the suture tied.
It is further within the scope of this invention to incorporate one or more medico-surgically useful substances into the presently disclosed polymers and surgical articles, e.g., those medico-surgically useful substances which accelerate or beneficially modify the healing process when particles are applied to a surgical repair site. So, for example, the suture can carry a therapeutic agent which will be deposited at the repair site. The therapeutic agent can be chosen for its antimicrobial properties, capability for promoting repair or reconstruction and/or new tissue growth. Antimicrobial agents such as broad spectrum antibiotic (gentamycin sulfate, erythromycin or derivatized glycopeptides) which are slowly released into the tissue can be applied in this manner to aid in combating clinical and sub-clinical infections in a tissue repair site. To promote repair and/or tissue growth, one or several growth promoting factors can be introduced into the sutures, e.g., fibroblast growth factor, bone growth factor, epidermal growth factor, platelet derived growth factor, macrophage derived growth factor, alveolar derived growth factor, monocyte derived growth factor, magainin, and so forth. Some therapeutic indications are: glycerol with tissue or kidney plasminogen activator to cause thrombosis, superoxide dimutase to scavenge tissue damaging free radicals, tumor necrosis factor for cancer therapy or colony stimulating factor and interferon, interleukin-2 or other lymphokine to enhance the immune system.
It is contemplated that it may be desirable to dye the sutures in order to increase visibility of the suture in the surgical field. Dyes known to be suitable for incorporation in sutures can be used. Such dyes include but are not limited to carbon black, bone black, D&C Green No. 6, and D&C Violet No. 2 as described in the handbook of U.S. Colorants for Food, Drugs and Cosmetics by Daniel M. Marrion (1979) . Preferably, sutures in accordance with the invention are dyed by adding up to about a few percent and preferably about 0.2% dye, such as D&C Violet No. 2 to the resin prior to extrusion, although addition of the dye during polymerization is also suitable. In order that those skilled in the art may be better able to practice the compositions and methods described herein, the following examples are given as an illustration of the preparation of random polymers as well as of the preparation and superior characteristics of sutures made from the random copolymers. It should be noted that the invention is not limited to the specific details embodied in the examples and further that all ratios or parts recited are by weight, unless otherwise indicated.
EXAMPLE 1
Dry glycolide (1320 grams) , dry 1-lactide (300 grams) , and distilled epsilon-caprolactone (380 grams) were added to a reactor along with 0.24 grams of distilled stannous octoate and 0.2 grams of distilled diethylene glycol (DEG) . The mixture was dried for about 21 hours and 40 minutes with agitation under flow of nitrogen. The reactor temperature was then set at 100 "C. When the temperature of the reaction vessel reached 100 "C, the temperature was maintained for about 15 minutes. Then the temperature of the reaction vessel was raised to 150 "C and then the reaction vessel heated for about an additional 15 minutes . The temperature of the reaction was then raised to about 190 "C and polymerization conducted with stirring under a nitrogen atmosphere for about 25 hours and 40 minutes.
The reaction product is then isolated, comminuted, and treated to remove residual reactants using known techniques. The treatment to remove residual reactants occurs at 100 "C for 48 hours under vacuum. NMR analysis, using a commercially available Bruker NMR, model number DPX-300, revealed the resultant polymer contained 12.9 weight percent lactide, 16.6 weight percent caprolactone, and 70.5 weight percent glycolide.
EXAMPLE 2 Dry glycolide (4080 grams) , dry 1-lactide (900 grams) , and distilled epsilon-caprolactone (1020 grams) were added to a reactor along with 0.72 grams of distilled stannous octoate and 1.2 grams of distilled diethylene glycol (DEG) . The mixture was dried for about 18.75 hours with agitation under flow of nitrogen. The reactor temperature was then set at 100 "C. When the temperature of the reaction vessel reached 100 "C, the temperature was maintained for about 15 minutes . Then the temperature of the reaction vessel was raised to 150 *C and then the reaction vessel heated for about an additional 15 minutes. The temperature of the reaction vessel was then raised to about 190 *C and polymerization conducted with stirring under a nitrogen atmosphere for about 23 hours and 10 minutes.
The reaction product is then isolated, comminuted, and treated to remove residual reactants using known techniques. The treatment to remove residual reactants occurs at 90 'C for 48 hours under vaccuum. NMR analysis, using a commercially available Bruker NMR, model number DPX-300, revealed the resultant polymer contained 12.5 weight percent lactide, 15.3 weight percent caprolactone, and 72.2 weight percent glycolide.
EXAMPLE 3
Dry glycolide (3960 grams) , dry 1-lactide (1020 grams) , and distilled epsilon-caprolactone (1020 grams) were added to a reactor along with 0.72 grams of distilled stannous octoate and 0.6 grams of distilled diethylene glycol (DEG). The mixture was dried for about 10 hours with agitation under flow of nitrogen. The reactor temperature was then set at 100 *C. When the temperature of the reaction vessel reached 100 *C, the temperature was maintained for about 15 minutes. Then the temperature of the reaction vessel was raised to 150 "C and the reaction vessel heated for about an additional 15 minutes . The temperature of the reactants was then raised to about 190 'C and polymerization conducted with stirring under a nitrogen atmosphere for about 22 hours and 35 minutes.
The reaction product is then isolated, comminuted, and treated to remove residual reactants using known techniques. The treatment to remove residual reactants occurs at 90 *C for 48 hours under vacuum. NMR analysis, using a commercially available Bruker NMR, model number DPX-300, revealed the resultant polymer contained 14.5 weight percent lactide, 14.9 weight percent caprolactone, and 70.6 weight percent glycolide.
Example 4
Dry glycolide (4200 grams) , dry 1-lactide (780 grams) , and distilled epsilon-caprolactone (1020 grams) were added to a reactor along with 0.72 grams of distilled stannous octoate and 0.6 grams of distilled diethylene glycol (DEG) . The mixture was dried for about 5.75 hours with agitation under flow of nitrogen. The reactor temperature was then set at 100 *C. When the temperature of the reaction vessel reached 100 *C the temperature was maintained for about 15 minutes . Then the temperature of the reaction vessel was raised to about 150 °C and then the reaction vessel heated for about an additional 15 minutes . The temperature of the reaction vessel was then raised to about 190 *C and polymerization conducted with stirring under a nitrogen atmosphere for about 23 hours and 15 minutes.
The reaction product is then isolated, comminuted, and treated to remove residual reactants using known techniques. The treatment to remove residual reactants occurs at 90 "C for 48 hours under vacuum. NMR analysis, using a commercially available Bruker NMR, model number DPX-300, revealed the resultant polymer contained 11.2 weight percent lactide, 14.2 weight percent caprolactone, and 74.6 weight percent glycolide. Table I below sets forth typical conditions for extruding, stretching of size 3/0 sutures. All of the monofilament sutures were fabricated from the resins of Examples 1 - 4, respectively.
TABLE I
CONDITIONS OF MANUFACTURING VARIOUS SIZES OF MONOFILAMENT OF THE PRESENT INVENTION
Example 1 2 3 4
Suture Size 3/0 3/0 3/0 3/0
Process Conditions EXTRUSION extruder screw, rpm 4.6 3.0 2.1 3.8 pump, rpm 10.9 7.8 6.0 5.1 driven roller, mpm 2.21 0 0 0 barrel temp., 'C, zone A 143 137 136 150 barrel tem . , "C, zone B 146 143 140 155 barrel tem . , *C, zone C 150 143 144 156 clamp temp. , 'C, 151 143 140 155 adapter temp. , "C 151 144 143 158 spinneret temp . , 'C 151 149 148 162 block temp . , * C 151 146 140 160 barrel melt temp., °C 165 160 156 173 pump melt temp., "C 157 149 143 163 spinneret melt temp., 'C N/A 158 155 174 barrel pressure, psi 1060 550 580 520 pump pressure, psi 1000 500 500 500 spinneret pressure, psi 1480 470 810 430 pump size, cc per revolution 0.16 0.16 0.16 0.16 diameter of spinneret, orifices, mm 1.2 1.2 1.2 1.2 no. of spinneret orifices 1 1 1 1 quench bath tem . , "C 25 25 25 25 Stretching (Orienting) Operation Example 1 2 3 4 draw bath temp . , * C N/A N/A N/A N/A first godet station, mpm 2.34 1.5 1.2 1.-2 Example 1 2 3 4 second godet, mpm 15.8 12.2 9.6 9.1 third godet station, mpm 23.0 16.5 13.1 11.9 fourth godet station,mpm 19.0 15.2 11.7 9.5 first oven temp, °C 40 38 38 38 second oven temp, °C 85 109 92 108 third oven temp, ' C 105 105 98 110
overall draw ratio 9.82:1 11:1 10.92:1 9.9:1 Relaxation 17% 10.7% 10% 20%
ing Operation
Example 1 2 3 4 annealing temp., °C 105 110 100 110 time (hrs . ) 6 6 6 6
The physical properties of the sutures and the procedures employed for their measurement are set forth in Table II as follows :
TABLE II
PROCEDURES FOR MEASURING PHYSICAL PROPERTIES OF MONOFILAMENT SUTURES OF THE PRESENT INVENTION
Physical Property Test Procedure knot-pull strength, kg U.S. P. XXI, tensile strength, sutures (881) straight-pull strength, kg ASTM D-2256, Instron Corporation elongation, % ASTM D-2256 tensile strength, kg/mm.2 ASTM D-2256, Instron Corporation Series IX Automated Materials Testing System 1.03A
Young' s Modulus Instron Merlin Software version 2000 Series IX calculation 18-3 (commercially available from Instron Corporation)
Table III below sets forth the physical properties of the size 3/0 suture of the present invention.
TABLE III
Physical Property Example 1 Example 2 Example 3 Example 4 diameter (mm) .324 0.316 .319 .319 knot-pull strength (kg) 2.64 2.51 2.29 2.99 Young's Modulus (kpsi) 380 661 523 734 Elongation % 38 19 27 29 Tensile Strength (kpsi) 64.3 81.8 73.9 94.5
As the data in Tables III illustrates, the suture made of the copolymer provided herein shows a desired physical properties, such as modulus and tensile strength.
INVITRO STRENGTH RETENTION Monofilament sutures manufactured in accordance with the above described process using the copolymer of Example 1 were tested for in vitro strength retention. In vitro loop-pull strength retention is indicative of in vivo strength retention. The in vitro strength retention of the suture was tested as follows :
To simulate in vivo conditions, the suture samples were stored in a container filled with Sorenson's buffer solution at 37 "C. After various periods of time, the suture samples were then removed from the container to test their loop-pull strength as follows. A knotted loop was formed. in a test suture in three steps as shown in FIGS. 3A - 3C. As shown in step 1 of FIG 3A , each suture was given a double throw (left over right ) around a 2 cm diameter cylinder. In Step 2, the free ends of the suture were set in a single throw (right over left) onto the initial throw of step 1. Finally, in step 3, another double throw ( left over right) was set onto the single throw of Step 2 to complete the knot. The free ends of the suture were cut to approximately 0.5 inches and the loop was carefully eased from the cylinder.
Testing of the loop was carried out using an Instron Tensile Tester Model No. 4307 (commercially available from Instron Corporation, Canton, Massachusetts) , operated with a crosshead speed of 51 mm/min and equipped with flat grips, each having a pin over which the loop is positioned.
The results of the tests are presented in Table IV hereinbelow. In the strength retention data reported in Table IV, Tn represents the time elapsed in weeks since the sample was placed in the solution, with n representing the number of weeks .
TABLE IV
PERCENTAGE OF IN VITRO STRENGTH RETAINED COMPOSITION TI T2 T3
EXAMPLE 1 23 15 0
EXAMPLE 2 34 3 0
EXAMPLE 3 32 0
MONOCRYL 58 26 3
IN VITRO MASS LOSS Monofilament sutures manufactured in accordance with the above described process using the polymer of Examples 1-4 were tested for in vitro mass retention. In vitro mass retention strength is indicative of in vivo mass retention. The in vitro strength retention of the suture was tested as follows :
To simulate in vivo conditions, the suture samples were weighed and stored in a fritted microencapsulation thimble (commercially available from Chemglass, Inc., Vineland, New Jersey) , which was placed in a scintillation vial filled with Sorenson's buffer solution. The scintillation vials were then pOlaced in a water bath at 80 "C. After various periods of time, the microextraction thimbles containing the suture samples were then removed from the scintillation vial, vacuum filtered, rinsed with distilled water, vacuum filtered, and dried for about 6 hours at about 40 "C under vacuum and subsequently the suture and thimble were weighed. The weight of the suture remaining was calculated by substracting the weight of the thimble from the weight of the thimble containing the remaining suture. The percentage of the suture retained was calculated by dividing the weight of the remaining suture by the original weight of the suture and multiplying the result by 100.
The results of the tests are presented in Table V hereinbelow. In the mass retention data reported in Table V, Tn represents the time elapsed in hours since the sample was placed in the solution, with n representing the number of hours . It is well known in the art that one hour of immersion in the container filled with Sorenson's buffer solution at 80 "C approximates about one day of invivo mass loss. For comparison purposes, the same tests were conducted on Monocryl sutures . All comparative tests were performed on size 3/0 sutures. T ABLE V
PERCENTAGE OF IN VITRO MASS RETAINED
COMPOSITION Ti T2 T3 T4 T6 T8 TlO Tl2
Time (hr) 8 24 32 48 56 72 96 120
EXAMPLE 1 90.52 42.58 35 .35 25.54 23 .50 19.56 12.94 11.43
EXAMPLE 2 88.32 43.96 33.77 24.83 22.63 18.7 14.76 11.72
EXAMPLE 3 92.05 40.91 28.26 21.56 18 .36 15.0 12.71 8.73
EXAMPLE 4 89.28 54.15 42.95 32.81 29 .24 23 .74 18 .68 13 .33
Monocryl 94.86 74.79 66.83 47.95 42.63 35.31 32 . 14 27.32
Modifications and variations of the compositions and processes disclosed herein are possible in light of the above teachings. It is therefore to be understood that changes may be made in particular embodiments described which are within the full intended scope of the invention as defined by the claims .

Claims

WHAT IS CLAIMED IS:
1. A medical device fabricated totally or in part from a random polymer comprising from about 70 to about 76 weight percent glycolide, about 14 to about 17 weight percent epsilon- caprolactone, and about 9 to about 15 weight percent lactide.
2. The medical device of claim 1 wherein the device is a surgical suture.
3. The suture of claim 2 wherein the random polymer comprises about 70.6 weight percent glycolide, about 14.9 weight percent caprolactone, and about 14.5 weight percent lactide.
4. The suture of claim 2 wherein the suture exhibits two week strength retention of about 15%, as measured in Sorenson's buffer solution at 37 *C.
5. The suture of claim 2 wherein the suture exhibits a mass loss of about 91% in 96 hours as measured in Sorenson's buffer solution at 80 °C.
6. The suture of claim 2 wherein the suture exhibits a modulus ranging from about 380 kpsi to about 760 kpsi.
7. The suture of claim 2 wherein the suture exhibits a knot pull strength of about 2.0 to about 3.0 kg.
8. The suture of claim 2 wherein the suture is a size 3/0 suture exhibiting a modulus of about 523 kpsi.
9. The suture of claim 1 wherein the suture is a size 3/0 suture exhibiting a knot pull strength of about 2.3 kg.
10. The suture of claim 1 wherein the suture is a size 3/0 suture exhibiting a tensile strength of about 100 kpsi.
11. The suture of claim 1 wherein the suture is a size 3/0 suture exhibiting the following characteristics: modulus about 350 to about 750 kpsi knot pull strength about 2.2 to about 3 kg tensile strength about 64 to about 105 kpsi.
12. The medical device of claim 1 comprising a medico- surgically useful substance.
13. The suture of claim 1 wherein the random polymer possesses an inherent viscosity of about 0.9 to about 1.8 dl/g at 30 °C and at a concentration of 0.25 g/dl in HFIP.
14. The suture of claim 1 wherein the suture is a size 3/0 suture and exhibits a mass loss of about 50% after 24 hours in Sorenson's buffer solution at 80 "C.
15. The suture of claim 1 wherein the suture is a size 3/0 suture and exhibits a mass loss of about 70% after 48 hours in Sorenson's buffer solution at 80 'C.
16. The suture of claim 1 wherein the suture is a size 3/0 suture and exhibits a mass loss of greater than about 85% after 120 hours in Sorenson's buffer solution at 80'C.
17. The medical device of claim 1 wherein the device is a staple, clip, other fastener, pin, screw, prosthetic device, mesh, or felt.
18. The medical device of claim 1 wherein the random polymer is blended with at least one another absorbable composition.
19. The medical device of claim 1 wherein the random copolymer is copolmerized with one other absorbable composition.
20. A method of suturing a wound comprising: a. providing a suture fabricated from a random polymer comprising from about 70 about 76 weight percent glycolide, about 14 to about 17 weight percent epsilon- caprolactone, and about 9 to about 15 weight percent lactide; and b. passing said needled suture through tissue to create wound closure.
21. A process for manufacturing a monofilament suture from a resin of a random copolymer, the random polymer comprising from about 70 about 76 weight percent glycolide, about 14 to about 17 weight percent epsilon-caprolactone, and about 9 to about 15 weight percent lactide, which comprises the operations of : a. extruding said resin at an extrusion temperature of from about 130 'C to about 190 °C to provide a monofilament ; b. stretching the solidified monofilament at a stretch ratio of from about 5:1 to about 13:1 to provide a stretched monofilament.
22. The process of claim 21 further comprising the steps of: a. annealing said stretched monofilament at a temperature of from about 80°C to about 125 'C to provide a finished suture.
23. A method of manufacturing a monofilament suture from a resin of a random copolymer, the random copolymer comprising caprolactone, lactide, and glycolide, which comprises : a) extruding the copolymer to provide a molten monofilament ; b) quenching the molten monofilament to provide a solidified monfilament; c) drawing the solidified monofilament through an air oven maintained at a temperature of about 25 'C to about 40 "C at a draw ratio of about 5:1 to about 10:1; d) drawing the monofilament through an air oven maintained at a temperature of about 80 "C to about 115 °C at a draw ratio of about 1.1:1 to about 2.6:1; e) drawing the monofilament through an air oven maintained at a temperature of about 80 *C to about 125 "C at a draw ratio of about 0.75:1 to about 1.05:1; and f) annealing the monofilament.
24. The method of claim 23 wherein the random copolymer comprises from about 70 about 76 weight percent glycolide, about 14 to about 17 weight percent epsilon-caprolactone, and about 9 to about 15 weight percent lactide.
PCT/US1999/012683 1998-07-06 1999-06-07 Absorbable polymers and surgical articles fabricated therefrom WO2000001307A1 (en)

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CA002337133A CA2337133C (en) 1998-07-06 1999-06-07 Absorbable polymers and surgical articles fabricated therefrom
DE69943023T DE69943023D1 (en) 1998-07-06 1999-06-07 ABSORBABLE POLYMERS AND SURGICAL PRODUCTS MANUFACTURED THEREOF
AU44239/99A AU4423999A (en) 1998-07-06 1999-06-07 Absorbable polymers and surgical articles fabricated therefrom
EP99927296A EP1094755B1 (en) 1998-07-06 1999-06-07 Absorbable polymers and surgical articles fabricated therefrom

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CA2337133A1 (en) 2000-01-13
US6165202A (en) 2000-12-26
DE69943023D1 (en) 2011-01-20
EP1094755A1 (en) 2001-05-02

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