WO1998011927A1 - Expulsion member for advancing the stopper of a syringe ampoule and a corresponding stopper - Google Patents

Expulsion member for advancing the stopper of a syringe ampoule and a corresponding stopper Download PDF

Info

Publication number
WO1998011927A1
WO1998011927A1 PCT/CH1996/000325 CH9600325W WO9811927A1 WO 1998011927 A1 WO1998011927 A1 WO 1998011927A1 CH 9600325 W CH9600325 W CH 9600325W WO 9811927 A1 WO9811927 A1 WO 9811927A1
Authority
WO
WIPO (PCT)
Prior art keywords
stopper
output member
plug
ampoule
connection
Prior art date
Application number
PCT/CH1996/000325
Other languages
German (de)
French (fr)
Inventor
Jürg Steck
Christoph Renggli
Original Assignee
Disetronic Licensing Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Disetronic Licensing Ag filed Critical Disetronic Licensing Ag
Priority to PCT/CH1996/000325 priority Critical patent/WO1998011927A1/en
Publication of WO1998011927A1 publication Critical patent/WO1998011927A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31511—Piston or piston-rod constructions, e.g. connection of piston with piston-rod
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31511—Piston or piston-rod constructions, e.g. connection of piston with piston-rod
    • A61M5/31515—Connection of piston with piston rod

Definitions

  • Output element for feeding a stopper of a spray ampoule and stopper for this.
  • the invention relates to an output member for advancing a stopper of a spray ampoule according to the preamble of claim 1 and a matching stopper according to the preamble of claim 10.
  • Injection vials are essentially hollow cylindrical containers which are closed on one side with a movable piston and on the other side by an outlet piece.
  • Infusion systems are known from the prior art which store the medicament to be administered in a spray ampoule in which the medicament is located between a movable stopper and a piercing membrane.
  • An output member moves the stopper in the direction of the needle, as a result of which medicine is pushed into the catheter through a connecting needle.
  • Stopper retainers for infusion devices are also known in which the driven member can be connected to the stopper in such a way that the stopper has, for example at its rear end, a cylindrical opening into which the driven member can be inserted and connected.
  • the cylindrical opening is a drilled thread so that the ampoule can first be filled using a pull-up rod.
  • the pull-up rod is unscrewed and the ampoule is inserted into the infusion device (pump) and connected to the output member.
  • the dispensing mechanism works in such a way that the threaded rod is rotatable and axially displaceable, while the threaded nut is non-rotatable and axially fixed.
  • the rotating threaded rod is connected to the plug in such a way that a connecting element is placed on the threaded rod, which is rotatable relative to the threaded rod but is axially fixed, so that the threaded rod rotates but not the connecting element in the plug.
  • ampoules which are inserted into an injection device. These ampoules are usually pre-filled, so there is no reason to provide the stopper with a threaded hole for a pull-up rod. If such a prefilled ampoule is now to be inserted into an infusion device, there is no possibility of connecting the output member stopper.
  • the invention seeks to remedy this.
  • the invention has for its object to provide an output member for a stopper, so that a non-positive and / or positive locking connection can be established between the stopper of an ampoule and an output member.
  • the invention has for its object to provide a stopper for non-positive and / or positive connection with an output member according to the invention.
  • the invention solves the problem with an output member having the features of claim 1 and a stopper which has the features of claim 10.
  • FIG. 1 shows a longitudinal section through a prefilled spray ampoule with a stopper without a threaded bore
  • FIG. 2 shows an output member according to the invention with a mandrel for the plug of the spray ampoule according to FIG. 1;
  • FIG. 2a shows an output member according to the invention with a roof-shaped needle for the stopper of the spray ampoule according to FIG. 1; 3 shows a variant of the output member according to the invention with a suction cup;
  • Fig. 4 shows a variant of the inventive output member with an adhesive
  • FIG. 5 shows a partial longitudinal section through a prefilled spray ampoule with a stopper with a magnet
  • FIG. 6 shows an output element according to the invention with a magnet for the plug of the spray ampoule according to FIG. 5;
  • FIG. 7 shows a partial longitudinal section through a prefilled spray ampoule with a stopper with Velcro fastener
  • FIG. 8 shows an output element according to the invention with a Velcro fastener for the stopper of the spray ampoule according to FIG. 7;
  • FIG. 9 shows an output element according to the invention with a self-tapping screw for the stopper of the spray ampoule according to FIG. 1;
  • FIG. 10 shows a partial longitudinal section through a prefilled spray ampoule with a stopper with click closure; and 11 shows an output element according to the invention with a click closure for the stopper of the spray ampoule according to FIG. 10.
  • the output member 1 shown in FIG. 2 is used to advance a stopper 2 shown in FIG. 1 of a spray ampoule 3 for dispensing a liquid medicament 4, the stopper 2 having no bore with an internal thread for receiving a pull-up rod.
  • the end of the output member 1 intended for abutment on the stopper 2 is provided with means 5 which permit a non-positive and / or positive connection to the stopper 2, with the exception of a threaded connection.
  • Elements 5 with a tip are very generally suitable as means 5.
  • the stopper 2 of the spray ampoule 3 is normally made of rubber. It is therefore possible to penetrate the rubber with a pointed object. If the dispensing mechanism is designed in such a way that the threaded rod is non-rotatable and axially displaceable, only the end of the output member facing the plug 2 has to be designed with a tip and the tip pushed into the plug 2. If the delivery mechanism of the infusion system is configured in such a way that its threaded rod is rotatable and axially displaceable, the tip for connecting the output member to the stopper 2 is located at the end of the connecting element facing the stopper 2.
  • the shape of the pointed object is preferably a roof-shaped needle (FIG. 2a).
  • the shape of the roof makes it possible for the needle not to slide in a certain direction when it enters the stopper 2, as would be the case with a one-sided bevel cut.
  • the force that drives the mandrel out of the plug (V) must therefore be smaller than the friction (R ⁇ ) that exists between the mandrel and the rubber compound.
  • the friction must also withstand a water column (W) of a certain size.
  • the power of the water column (W) and displacement of the cathedral (V) are to be added and must be less than the friction between the outer surface of the dome and the rubber stopper (R d ) and between the rubber stopper and the inner wall of the ampoule (R a ):
  • the friction between the rubber stopper and stopper 2 is additionally increased when the outer diameter of the pointed object - as is usual with a tip - increases below the tip, in order then to decrease against the connecting element (FIG. 2a).
  • a roof-shaped needle is ideal, the outside diameter of which decreases below the roof, towards the end opposite the tip.
  • a screw 12 can be provided as a means for connection to the stopper 2.
  • the advantage of a self-tapping screw corresponds to that of a nail compared to a screw, - a separation of the parts connected thereby requires a greater effort.
  • Such a screw connection is expediently primarily used together with a non-rotatable threaded rod, because in the case of a rotatable threaded rod, the screw 12 is welded to a rotatable connecting element, so that in the latter embodiment, the screw 12 could only be screwed into the stopper 2 with additional auxiliary elements.
  • a suction cup 6 can be provided as a means for connection to the plug 2 instead of a Do s or a needle 5.
  • the advantage of this solution compared to a pointed object or a screw is that neither the plug 2 is injured nor the user can injure himself.
  • Another advantage of this type of connection is that the suction cup 6 and thus, depending on the type of connection suction cup threaded rod, the threaded rod (in contrast to solutions which require adhesive) can be reused.
  • the maximum outside diameter of the suction cup 6 is somewhat smaller than the inside diameter of the ampoule.
  • the surface of the stopper 2 should be as smooth as possible.
  • an adhesive 7 can also be provided as a means for connection to the stopper 2.
  • An adhesive 7 is preferably used, which can be connected to different materials.
  • the drug resistance should be guaranteed.
  • the threaded rod will not be used again because a release from the plug 2 is not possible or only under difficult conditions.
  • the adhesive 7 can already be attached to the threaded rod (or on the stopper 2) and secured against drying out with a cover.
  • a magnet 8 can also be provided as a means for connection to the stopper 2. Basically, it is sufficient if either the threaded rod or the plug 2 is magnetic, while the remaining part can be magnetic or just a piece of metal.
  • the magnet 8 - or just a piece of metal - can be in or on the plug 2.
  • the advantage of this version is that the threaded rod can be reused.
  • the threaded rod itself can be magnetic or can be provided with a further magnet 9 (FIG. 5).
  • a Velcro fastener 10, 11 can also be provided as a means for connection to the stopper 2.
  • the advantage of this version is that the threaded rod can be reused.
  • the adhesive mentioned above can be used to attach the two parts of the Velcro fastener 10, 11 to the stopper 2 and to the threaded rod.
  • Common Velcro fasteners are sold under the VELCRO TM brand.
  • a click closure 13, 14 can also be provided as a means for connection to the stopper 2.
  • the threaded rod can also be reused in this embodiment.
  • the click fastener 13, 14 can be realized in various ways. When decoupling plug 2 and threaded rod, it should not be forgotten that plug 2 is at the lowest end of the ampoule when the threaded rod is to be decoupled. It is therefore primarily an axial movement through which the plug 2 and the threaded rod are separated.
  • the click lock 13, 14 consists of a spherical body 13 attached to the threaded rod and a concave receiving body 14 for the spherical body 13 attached to the stopper 2.

Abstract

This invention concerns an expulsion member (1) for advancing the stopper (2) of a syringe ampoule (3) to administer liquid medicament (4). The stopper (2) has no orifice with an internal thread for taking up a drawing rod. The end of the expulsion member (1) is for seating against the tampon (2) is provided with elements (5, 6, 7, 8, 10, 12, 13) which make possible a frictional and/or interlocking connection with the stopper (2) with the exception of a threaded connection. This makes it possible to have the advantage of being able to easily use pre-filled ampoules with stoppers (2) without a threaded orifice for a drawing rod in an infusion apparatus.

Description

Abtriebsglied für den Vorschub eines Stopfens einer Spritzampulle und Stopfen hierzu.Output element for feeding a stopper of a spray ampoule and stopper for this.
Die Erfindung betrifft ein Abtriebεglied für den Vorschub eines Stopfens einer Spritzampulle gemass dem Oberbegriff des Patentanspruchs 1 sowie einen dazu passenden Stopfen gemass dem Oberbegriff des Patentanspruchs 10.The invention relates to an output member for advancing a stopper of a spray ampoule according to the preamble of claim 1 and a matching stopper according to the preamble of claim 10.
Ξpritzampullen sind im wesentlichen hohlzylindrische Behälter, welche auf der einen Seite mit einem beweglichen Kolben und auf der anderen Seite durch ein Auslaεsstück verschlossen sind.Injection vials are essentially hollow cylindrical containers which are closed on one side with a movable piston and on the other side by an outlet piece.
Aus dem Stand der Technik sind Infuεionεsysteme bekannt, welche das zu verabreichende Arzneimittel in einer Spritz -Ampulle lagern, in welcher sich das Arzneimittel zwischen einem beweglichen Stopfen und einer Durchstechmembrane befindet. Ein Abtriebsglied bewegt den Stopfen in Richtung Nadel, dadurch wird Arzneimittel durch eine Verbindungsnadel in den Katheter gestossen. Sobald dieser Katheter mit Arzneimittel gefüllt ist, wird das vordere Ende des Katheters in den Körper eines Organismus geleitet und eine genaue Dosis Arzneimittel kann verabreicht werden.Infusion systems are known from the prior art which store the medicament to be administered in a spray ampoule in which the medicament is located between a movable stopper and a piercing membrane. An output member moves the stopper in the direction of the needle, as a result of which medicine is pushed into the catheter through a connecting needle. Once this catheter is filled with medication, the front end of the catheter is inserted into the body of an organism and an exact dose of medication can be administered
Die Nachteile dieser Anordnung bestehen darin, dass sich bei einer gewissen Höhendifferenz zwischen Ampulle und unterem Katheterende die Ampulle durch die Kraft der Wassersäule selbst entleeren kann. Dieser Gefahr kann durch Ausgestaltung des Stopfens der Spritzampulle begegnet werden, indem entweder die Reibung zwischen der Wand der Glasampulle und dem Stopfen vergrössert wird oder der Stopfen in irgendeiner Weise gehalten wird. Die Vergrösserung der Reibung ist nicht sinnvoll, weil sonst das Infusionssystem zur Bewegung des Stopfens zuviel Energie aufwenden muss, um diesen in Richtung Nadel zu stossen. Wird der Stopfen aber vom Abtriebsglied gehalten, kann diese Entleerung durch die Kraft der Wassersäule nicht eintreten, da das Abtriebsglied den Stopfen in seiner Position hält.The disadvantages of this arrangement are that if there is a certain height difference between the ampoule and the lower end of the catheter, the ampoule can empty itself due to the force of the water column. This danger can be countered by designing the stopper of the spray ampoule, either by increasing the friction between the wall of the glass ampoule and the stopper or by holding the stopper in any way. Increasing the friction does not make sense, because otherwise the infusion system has to use too much energy to move the plug to push it towards the needle. However, if the plug is held by the driven member, this emptying cannot occur due to the force of the water column, since the driven member holds the plug in its position.
Es sind auch Stopfenrückhalterungen für Infusionsgeräte bekannt, bei denen das Abtriebsglied mit dem Stopfen derart verbindbar ist, dass der Stopfen z.B. an seinem hinteren Ende eine zylindrische Öffnung aufweist, in welche das Abtriebsglied eingeführt und verbunden werden kann. Es handelt sich bei der zylindrischen Öffnung um ein eingebohrtes Gewinde, damit die Ampulle mittels einer Aufziehstange zuerst gefüllt werden kann. Ist die Ampulle gefüllt, wird die Aufziehstange abgeschraubt und die Ampulle in das Infusionsgerät (Pumpe) eingesetzt und mit dem Abtriebsglied verbunden. Bei einigen dieser bekannten Pumpen-Systeme funktioniert die Abgabemechanik derart, dass die Gewindestange drehbar und axial verschiebbar ist, während die Gewindemutter drehfest und axial fest ist. Die sich drehende Gewindestange wird mit dem Stopfen derart verbunden, dass auf die Gewindestange ein Verbindungselement gesetzt wird, welches gegenüber der Gewindestange drehbar, aber axial fest ist, so dass sich zwar die Gewindestange dreht, nicht aber das Verbindungseiement im Stopfen.Stopper retainers for infusion devices are also known in which the driven member can be connected to the stopper in such a way that the stopper has, for example at its rear end, a cylindrical opening into which the driven member can be inserted and connected. The cylindrical opening is a drilled thread so that the ampoule can first be filled using a pull-up rod. When the ampoule is filled, the pull-up rod is unscrewed and the ampoule is inserted into the infusion device (pump) and connected to the output member. In some of these known pump systems, the dispensing mechanism works in such a way that the threaded rod is rotatable and axially displaceable, while the threaded nut is non-rotatable and axially fixed. The rotating threaded rod is connected to the plug in such a way that a connecting element is placed on the threaded rod, which is rotatable relative to the threaded rod but is axially fixed, so that the threaded rod rotates but not the connecting element in the plug.
Anders verhält es sich bei Ampullen, welche in ein Injektionsgerät eingesetzt werden. Diese Ampullen sind meist vorabgefüllt, so dass kein Grund besteht, den Stopfen mit einer Gewindebohrung für eine Aufziehstange zu versehen. Soll nun eine solche vorabgefüllte Ampulle in ein Infusionsgerät eingesetzt werden, gibt es keine Verbindungsmöglichkeit Abtriebsglied-Stopfen.The situation is different with ampoules which are inserted into an injection device. These ampoules are usually pre-filled, so there is no reason to provide the stopper with a threaded hole for a pull-up rod. If such a prefilled ampoule is now to be inserted into an infusion device, there is no possibility of connecting the output member stopper.
Hier will die Erfindung Abhilfe verschaffen. Der Erfindung liegt die Aufgabe zugrunde ein Abtriebsglied für einen Stopfen zu schaffen, so dass zwischen dem Stopfen einer Ampulle und einem Abtriebsglied eine kraft- und/oder formschlüssige Rückhalte- Verbindung herstellbar ist. Im weiteren liegt der Erfindung die Aufgabe zugrunde einen Stopfen zur kraft- und/oder formschlüssigen Verbindung mit einem erfindungsgemässen Abtriebsglied zu schaffen. Die Erfindung löst die gestellte Aufgabe mit einem Abtriebsglied, welches die Merkmale des Anspruchs 1 aufweist, sowie einem Stopfen, welcher die Merkmale des Anspruchs 10 aufweis .The invention seeks to remedy this. The invention has for its object to provide an output member for a stopper, so that a non-positive and / or positive locking connection can be established between the stopper of an ampoule and an output member. Furthermore, the invention has for its object to provide a stopper for non-positive and / or positive connection with an output member according to the invention. The invention solves the problem with an output member having the features of claim 1 and a stopper which has the features of claim 10.
Damit ist der Vorteil erzielbar, dass vorabgefüllte Ampullen, deren Stopfen keine Gewindebohrung für eine Aufziehstange aufweisen, ohne Schwierigkeiten auch in ein Infusionsgerät eingesetzt werden können.The advantage can thus be achieved that pre-filled ampoules, the plugs of which do not have a threaded hole for a pull-up rod, can also be inserted into an infusion device without difficulty.
Die Erfindung und Weiterbildungen der Erfindung werden im folgenden anhand der teilweise schematischen Darstellungen mehrerer Ausführungsbeispiele noch näher erläutert. Es zeigen:The invention and further developments of the invention are explained in more detail below on the basis of the partially schematic representations of several exemplary embodiments. Show it:
Fig. l ein Längsschnitt durch eine vorabgefüllte Spritzampulle mit einem Stopfen ohne Gewindebohrung,-1 shows a longitudinal section through a prefilled spray ampoule with a stopper without a threaded bore,
Fig. 2 ein erfindungsgemässes Abtriebsglied mit einem Dorn für den Stopfen der Spritzampulle nach Fig. 1;FIG. 2 shows an output member according to the invention with a mandrel for the plug of the spray ampoule according to FIG. 1;
Fig. 2a ein erfindungsgemässes Abtriebsglied mit einer dachförmige Nadel für den Stopfen der Spritzampulle nach Fig. 1; Fig. 3 eine Variante des erfindungsgemassen Abtriebsgliedes mit einem Saugnapf;2a shows an output member according to the invention with a roof-shaped needle for the stopper of the spray ampoule according to FIG. 1; 3 shows a variant of the output member according to the invention with a suction cup;
Fig. 4 eine Variante des erfindungsgemassen Abtriebsgliedes mit einem Klebstoff ,• Fig. 4 shows a variant of the inventive output member with an adhesive, •
Fig. 5 einen teilweisen Längsschnitt durch eine vorabgefüllte Spritzampulle mit einem Stopfen mit Magnet;5 shows a partial longitudinal section through a prefilled spray ampoule with a stopper with a magnet;
Fig. 6 ein erfindungsgemässes Abtriebsglied mit einem Magnet für den Stopfen der Spritzampulle nach Fig. 5;6 shows an output element according to the invention with a magnet for the plug of the spray ampoule according to FIG. 5;
Fig. 7 einen teilweisen Längsschnitt durch eine vorabgefüllte Spritzampulle mit einem Stopfen mit Klettverschluss ;7 shows a partial longitudinal section through a prefilled spray ampoule with a stopper with Velcro fastener;
Fig. 8 ein erfindungsgemässes Abtriebsglied mit einem Klettverschluss für den Stopfen der Spritzampulle nach Fig. 7;8 shows an output element according to the invention with a Velcro fastener for the stopper of the spray ampoule according to FIG. 7;
Fig. 9 ein erfindungsgemässes Abtriebsglied mit einer selbstschneidenden Schraube für den Stopfen der Spritzampulle nach Fig. 1;9 shows an output element according to the invention with a self-tapping screw for the stopper of the spray ampoule according to FIG. 1;
Fig. 10 einen teilweisen Längsschnitt durch eine vorabgefüllte Spritzampulle mit einem Stopfen mit Klickverschluss; und Fig. 11 ein erfindungsgemässes Abtriebsglied mit einem Klickverschluss für den Stopfen der Spritzampulle nach Fig. 10.10 shows a partial longitudinal section through a prefilled spray ampoule with a stopper with click closure; and 11 shows an output element according to the invention with a click closure for the stopper of the spray ampoule according to FIG. 10.
Das in Fig. 2 dargestellte Abtriebsglied 1 dient dem Vorschub eines in Fig. 1 dargestellten Stopfens 2 einer Spritzampulle 3 zur Abgabe eines flüssigen Medikamentes 4, wobei der Stopfen 2 über keine Bohrung mit Innengewinde zur Aufnahme einer Aufziehstange verfügt.The output member 1 shown in FIG. 2 is used to advance a stopper 2 shown in FIG. 1 of a spray ampoule 3 for dispensing a liquid medicament 4, the stopper 2 having no bore with an internal thread for receiving a pull-up rod.
Das zur Anlage an den Stopfen 2 bestimmte Ende des Abtriebsglieds 1 ist mit Mitteln 5 versehen, welche eine kraft- und/oder formschlüssige Verbindung mit dem Stopfen 2 ermöglichen, mit Ausnahme einer Gewindeverbindung.The end of the output member 1 intended for abutment on the stopper 2 is provided with means 5 which permit a non-positive and / or positive connection to the stopper 2, with the exception of a threaded connection.
Als Mittel 5 eignen sich ganz allgemein Elemente mit einer Spitze, wie sie in den Fig. 2 und 2a dargestellt sind. Der Stopfen 2 der Spritzampulle 3 ist normalerweise aus Gummi gefertigt. Es ist daher möglich mit einem spitzen Gegenstand in den Gummi einzudringen. Ist die Abgabemechanik so ausgestaltet, dass die Gewindestange drehfest und axial verschiebbar ist, muss lediglich das dem Stopfen 2 zugewandte Ende des Abtriebsgliedes mit einer Spitze ausgestaltet werden und die Spitze in den Stopfen 2 gestossen werden. Ist die Abgabemechanik des Infusionssystems derart ausgestaltet, dass dessen Gewindestange drehbar und axial verschiebbar ist, befindet sich die Spitze zur Verbindung des Abtriebsgliedes mit dem Stopfen 2 an dem, dem Stopfen 2 zugewandten Ende des Verbindungselementes .Elements 5 with a tip, as shown in FIGS. 2 and 2a, are very generally suitable as means 5. The stopper 2 of the spray ampoule 3 is normally made of rubber. It is therefore possible to penetrate the rubber with a pointed object. If the dispensing mechanism is designed in such a way that the threaded rod is non-rotatable and axially displaceable, only the end of the output member facing the plug 2 has to be designed with a tip and the tip pushed into the plug 2. If the delivery mechanism of the infusion system is configured in such a way that its threaded rod is rotatable and axially displaceable, the tip for connecting the output member to the stopper 2 is located at the end of the connecting element facing the stopper 2.
Vorzugsweise ist die Form des spitzen Gegenstandes eine dachförmige Nadel (Fig. 2a) . Durch die Dachform wird ermöglicht, dass die Nadel beim Eindringen in den Stopfen 2 nicht - wie dies bei einem einseitigen Schrägschliff der Fall wäre - in eine bestimmte Richtung abgleitet.The shape of the pointed object is preferably a roof-shaped needle (FIG. 2a). The shape of the roof makes it possible for the needle not to slide in a certain direction when it enters the stopper 2, as would be the case with a one-sided bevel cut.
Wird eine Nadel in den Gummistopfen geschoben, gelangen Teile des Gummistopfens in den Hohlkörperteil der Nadel, d.h. während ein Dorn den Bereich des Stopfen in den er eindringt einzig verdrängt, findet bei gleicher Bewegung einer Nadel viel weniger Verdrängung statt, weil Gummiteile in die Nadel eindringen können. Dies setzt natürlich eine gewisse Schärfe der Kanten der Nadel voraus . Die Verdrängung der Gummimasse beim Eindringen des Doms bewirkt eine Kraft, welche den Dorn wieder aus dem Stopfen hinausdrängt (Verdrängungskraft = V) .When a needle is inserted into the rubber stopper, parts of the rubber stopper enter the hollow part of the needle, i.e. while a mandrel only displaces the area of the plug into which it penetrates, much less displacement takes place with the same movement of a needle, because rubber parts can penetrate the needle. Of course, this requires a certain sharpness of the edges of the needle. The displacement of the rubber mass when the dome penetrates causes a force which pushes the mandrel out of the plug (displacement force = V).
Die Kraft, welche den Dorn aus dem Stopfen treibt (V) , musε daher kleiner sein als die Reibung (R^) , welche zwischen Dorn und Gummimasse besteht. Gleichzeitig muss die Reibung auch eine Wassersäule (W) von einer bestimmten Grössenordnung aushalten. Die Kraft der Wassersäule (W) und Verdrängung des Doms (V) sind zu addieren und müssen kleiner sein als die Reibung zwischen Aussenfläche des Doms und Gummistopfen (Rd) und zwischen Gummistopfen und Innenwand der Ampulle (Ra) :The force that drives the mandrel out of the plug (V) must therefore be smaller than the friction (R ^) that exists between the mandrel and the rubber compound. At the same time, the friction must also withstand a water column (W) of a certain size. The power of the water column (W) and displacement of the cathedral (V) are to be added and must be less than the friction between the outer surface of the dome and the rubber stopper (R d ) and between the rubber stopper and the inner wall of the ampoule (R a ):
V + W ≤ (Rd) + (Ra)V + W ≤ (R d ) + (R a )
Zusätzlich vergrössert wird die Reibung zwischen Gummistopfen und Stopfen 2, wenn der Aussendurchmesser des spitzen Gegenstandes - wie bei einer Spitze üblich - unterhalb der Spitze zunimmt, um dann gegen das Verbindungselement abzunehmen (Fig. 2a) . Ideal ist demnach eine dachförmige Nadel, deren Aussendurchmesser unterhalb des Daches, gegen das der Spitze entgegengesetzte Ende, abnimmt.The friction between the rubber stopper and stopper 2 is additionally increased when the outer diameter of the pointed object - as is usual with a tip - increases below the tip, in order then to decrease against the connecting element (FIG. 2a). A roof-shaped needle is ideal, the outside diameter of which decreases below the roof, towards the end opposite the tip.
Wie in Fig. 9 dargestellt kann statt eines Dorns oder einer Nadel 5 eine Schraube 12 als Mittel zur Verbindung mit dem Stopfen 2 vorgesehen werden. Der Vorteil einer selbstschneidenden Schraube entspricht demjenigen eines Nagels gegenüber einer Schraube,- eine Trennung der dadurch verbundenen Teile bedarf eines grδsseren Kraftaufwandes. Zweckmässigerweise wird eine solche Schraubverbindung in erster Linie zusammen mit einer drehfesten Gewindestange verwendet, weil bei einer drehbaren Gewindestange die Schraube 12 mit einem drehbaren Verbindungselernent verschweisst wird, demnach könnte bei letzterer Ausführungsform die Schraube 12 nur mit zusätzlichen Hilfselementen in den Stopfen 2 geschraubt werden. Wie in Fig. 3 dargestellt kann statt eines Do s oder einer Nadel 5 ein Saugnapf 6 als Mittel zur Verbindung mit dem Stopfen 2 vorgesehen werden. Der Vorteil dieser Lösung, gegenüber einem spitzen Gegenstand oder einer Schraube, besteht darin, dass weder der Stopfen 2 verletzt wird, noch der Anwender sich verletzen kann. Ein weiterer Vorteil dieser Verbindungsart liegt darin, dass der Saugnapf 6 und damit, je nach Verbindungsart Saugnapf-Gewindestange, auch die Gewindestange (etwa im Gegensatz zu Lösungen, welche Klebstoff verlangen) wieder verwendbar ist.As shown in FIG. 9, instead of a mandrel or a needle 5, a screw 12 can be provided as a means for connection to the stopper 2. The advantage of a self-tapping screw corresponds to that of a nail compared to a screw, - a separation of the parts connected thereby requires a greater effort. Such a screw connection is expediently primarily used together with a non-rotatable threaded rod, because in the case of a rotatable threaded rod, the screw 12 is welded to a rotatable connecting element, so that in the latter embodiment, the screw 12 could only be screwed into the stopper 2 with additional auxiliary elements. As shown in Fig. 3, a suction cup 6 can be provided as a means for connection to the plug 2 instead of a Do s or a needle 5. The advantage of this solution compared to a pointed object or a screw is that neither the plug 2 is injured nor the user can injure himself. Another advantage of this type of connection is that the suction cup 6 and thus, depending on the type of connection suction cup threaded rod, the threaded rod (in contrast to solutions which require adhesive) can be reused.
Der maximale Aussendurchmesser des Saugnapfes 6 ist etwas kleiner als der Innendurchmesser der Ampulle. Die Oberfläche des Stopfens 2 sollte möglichst glatt sein.The maximum outside diameter of the suction cup 6 is somewhat smaller than the inside diameter of the ampoule. The surface of the stopper 2 should be as smooth as possible.
Wie in Fig. 4 dargestellt kann auch ein Klebstoff 7 als Mittel zur Verbindung mit dem Stopfen 2 vorgesehen werden. Auch bei dieser Lösung besteht der Vorteil - gegenüber einem spitzen Gegenstand und oder einer Schraube - darin, dass weder der Stopfen 2 verletzt wird, noch der Anwender sich verletzen kann. Vorzugsweise wird ein Klebstoff 7 verwendet, welcher mit verschiedenen Materialien verbunden werden kann. Im weiteren sollte die Medikamentenbeständigkeit gewährleistet sein. Bei dieser Verbindungsart ist davon auszugehen, dass die Gewindestange nicht wieder verwendet wird, weil eine Lösung vom Stopfen 2 nicht oder nur unter erschwerten Bedingungen, möglich ist. Um die Anwendung möglichst einfach zu gestalten, kann der Klebstoff 7 bereits an der Gewindestange (oder am Stopfen 2) angebracht sein und mit einer Abdeckung vor Austrocknung gesichert sein.As shown in FIG. 4, an adhesive 7 can also be provided as a means for connection to the stopper 2. With this solution, too, the advantage - compared to a pointed object and or a screw - is that neither the plug 2 is injured nor the user can injure himself. An adhesive 7 is preferably used, which can be connected to different materials. Furthermore, the drug resistance should be guaranteed. With this type of connection, it can be assumed that the threaded rod will not be used again because a release from the plug 2 is not possible or only under difficult conditions. To make the application as simple as possible, the adhesive 7 can already be attached to the threaded rod (or on the stopper 2) and secured against drying out with a cover.
Wie in den Fig. 5 und 6 dargestellt kann auch ein Magnet 8 als Mittel zur Verbindung mit dem Stopfen 2 vorgesehen werden. Grundsätzlich genügt es, wenn entweder die Gewindestange oder der Stopfen 2 magnetisch ist, während das verbleibende Teil magnetisch oder auch nur ein Metallstück sein kann. Der Magnet 8 - oder auch nur ein Metallstück - kann sich im oder am Stopfen 2 befinden. Der Vorteil dieser Ausführung ist, dass die Gewindestange wiederverwendet werden kann. Dabei kann die Gewindestange selbst magnetisch sein oder mit einem weiteren Magneten 9 versehen sein (Fig. 5) .As shown in FIGS. 5 and 6, a magnet 8 can also be provided as a means for connection to the stopper 2. Basically, it is sufficient if either the threaded rod or the plug 2 is magnetic, while the remaining part can be magnetic or just a piece of metal. The magnet 8 - or just a piece of metal - can be in or on the plug 2. The advantage of this version is that the threaded rod can be reused. The threaded rod itself can be magnetic or can be provided with a further magnet 9 (FIG. 5).
Wie in den Fig. 7 und 8 dargestellt kann auch ein Klettverschluss 10,11 als Mittel zur Verbindung mit dem Stopfen 2 vorgesehen werden. Der Vorteil dieser Ausführung ist, dass die Gewindestange wiederverwendet werden kann. Der oben erwähnte Klebstoff kann dazu dienen die beiden Teile des Klettverschlusses 10,11 am Stopfen 2 und an der Gewindestange anzubringen. Gebräuchliche Klettverschlüsse werden unter der Marke VELCRO™ vertrieben.As shown in FIGS. 7 and 8, a Velcro fastener 10, 11 can also be provided as a means for connection to the stopper 2. The advantage of this version is that the threaded rod can be reused. The adhesive mentioned above can be used to attach the two parts of the Velcro fastener 10, 11 to the stopper 2 and to the threaded rod. Common Velcro fasteners are sold under the VELCRO ™ brand.
Wie in den Fig. 10 und 11 dargestellt kann auch ein Klickver- schluss 13,14 als Mittel zur Verbindung mit dem Stopfen 2 vorgesehen werden. Auch bei dieser Ausführungsart kann die Gewindestange wiederverwendet werden. Der Klickverschluss 13,14 kann in verschiedenster Weise realisiert sein. Für die Entkoppelung von Stopfen 2 und Gewindestange darf allerdings nicht unberücksichtigt bleiben, dass der Stopfen 2 am untersten Ende der Ampulle ist, wenn die Gewindestange entkoppelt werden soll. Es ist daher primär eine axiale Bewegung, durch welche Stopfen 2 und Gewindestange getrennt werden. Der Klickverschluss 13,14 besteht aus einem an der Gewindestange angebrachten Kugelkörper 13 und einem am Stopfen 2 angebrachten konkaven Aufnahmekörper 14 für den Kugelkörper 13.As shown in FIGS. 10 and 11, a click closure 13, 14 can also be provided as a means for connection to the stopper 2. The threaded rod can also be reused in this embodiment. The click fastener 13, 14 can be realized in various ways. When decoupling plug 2 and threaded rod, it should not be forgotten that plug 2 is at the lowest end of the ampoule when the threaded rod is to be decoupled. It is therefore primarily an axial movement through which the plug 2 and the threaded rod are separated. The click lock 13, 14 consists of a spherical body 13 attached to the threaded rod and a concave receiving body 14 for the spherical body 13 attached to the stopper 2.
Zusammenfassend kann festgehalten werden, dass alle Lösungen, welche nicht zu einem Eindringen eines Gegenstandes in den Stopfen 2 führen, den Vorteil haben, dass weder Stopfen 2 noch der Anwender verletzt werden. In summary, it can be stated that all solutions which do not lead to the penetration of an object into the plug 2 have the advantage that neither the plug 2 nor the user are injured.

Claims

PATENTANSPRÜCHE PATENT CLAIMS
1. Abtriebsglied (1) für den Vorschub eines Stopfens (2) einer Spritzampulle (3) zur Abgabe eines flüssigen Medikamentes (4) , wobei der Stopfen (2) über keine Bohrung mit Innengewinde zur Aufnahme einer Aufziehstange verfügt, dadurch gekennzeichnet, dass das zur Anlage an den Stopfen (2) bestimmte Ende des Abtriebsglieds (1) mit Mitteln (5,6,7,8,10,12,13) versehen ist, welche eine kraft- und/oder formschlüssige Verbindung mit dem Stopfen (2) ermöglichen, mit Ausnahme einer Ge indeVerbindung.1. output member (1) for feeding a stopper (2) of a spray ampoule (3) for dispensing a liquid medicament (4), the stopper (2) having no bore with an internal thread for receiving a pull-up rod, characterized in that the end of the driven member (1) which is intended to rest against the stopper (2) is provided with means (5, 6, 7, 8, 10, 12, 13) which provide a non-positive and / or positive connection with the stopper (2) allow, with the exception of a common connection.
2. Abtriebsglied (1) nach Anspruch 1, dadurch gekennzeichnet, dass die Mittel (5,6,7,8,10,12,13) kraftschlüssig mit dem Stopfen (2) verbindbar sind.2. output member (1) according to claim 1, characterized in that the means (5,6,7,8,10,12,13) are non-positively connected to the plug (2).
3. Abtriebsglied (1) nach Anspruch 2, dadurch gekennzeichnet, dass die Mittel mindestens einen Dorn (5) oder eine Spitze oder eine Nadel, vorzugsweise eine dachförmige Nadel umfassen, welche in den Stopfen (2) einstechbar ist.3. output member (1) according to claim 2, characterized in that the means comprise at least one mandrel (5) or a tip or a needle, preferably a roof-shaped needle which can be inserted into the stopper (2).
4. Abtriebsglied (1) nach Anspruch 2, dadurch gekennzeichnet, dass die Mittel mindestens einen Saugnapf (6) umfassen, welcher am Stopfen (2) durch Vakuum befestigbar ist. 4. output member (1) according to claim 2, characterized in that the means comprise at least one suction cup (6) which can be attached to the plug (2) by vacuum.
5. Abtriebsglied (1) nach Anspruch 2, dadurch gekennzeichnet, dass die Mittel einen Klebstoff (7) umfassen, mit dem ein Kraftschlusε zwischen Abtriebsglied (1) und Stopfen (2) herstellbar ist.5. output member (1) according to claim 2, characterized in that the means comprise an adhesive (7) with which a non-positive connection between the output member (1) and plug (2) can be produced.
6. Abtriebsglied (1) nach Anspruch 2, dadurch gekennzeichnet, dass die Mittel mindestens einen Magneten (8) umfassen, der vorzugsweise mit einem am Stopfen (2) angebrachten zweiten Magneten (9) kraftschlüssig verbindbar ist.6. output member (1) according to claim 2, characterized in that the means comprise at least one magnet (8) which is preferably non-positively connected to a second magnet (9) attached to the stopper (2).
7. Abtriebsglied (1) nach Anspruch 2, dadurch gekennzeichnet, dass die Mittel einen Klettverschluss (10) umfassen, der mit einem am Stopfen (2) angebrachten zweiten Klettverschluss (11) kraftschlüssig verbindbar ist .7. output member (1) according to claim 2, characterized in that the means comprise a Velcro fastener (10) which is non-positively connected to a second Velcro fastener (11) attached to the stopper (2).
8. Abtriebsglied (1) nach Anspruch 1, dadurch gekennzeichnet, dass das zur Anlage an den Stopfen (2) bestimmte Ende des Abtriebsglieds (1) mit einer selbstschneidenden Schraube (12) versehen ist, welche in den Stopfen (2) einschraubbar ist.8. output member (1) according to claim 1, characterized in that the end of the output member (1) intended for bearing against the stopper (2) is provided with a self-tapping screw (12) which can be screwed into the stopper (2).
9. Abtriebsglied (1) nach Anspruch 1, dadurch gekennzeichnet, dass das zur Anlage an den Stopfen (2) bestimmte Ende des Abtriebsglieds (1) mit einem Verschlussteil (13) eines Klickverschlusses versehen ist, welcher in einen am Stopfen (2) angebrachten, korrespondierenden Verschlussteil (14) des Klickverschlusses einklickbar ist. 9. output member (1) according to claim 1, characterized in that that intended to abut on the stopper (2) end of the output member (1) is provided with a closure part (13) of a click closure, which is attached to a stopper (2) Corresponding closure part (14) of the click closure is clickable.
10. Stopfen (2) einer Spritzampulle (3) zur Abgabe eines flüssigen Medikamentes (4) , wobei der Stopfen (2) über keine Bohrung mit Innengewinde zur Aufnahme einer Aufziehstange verfügt, zur kraft- und/oder formschlüssigen Verbindung mit einem Abtriebsglied (1) nach einem der Ansprüche 1 - 9, dadurch gekennzeichnet, dass das die zur Anlage an das Abtriebsglied (1) bestimmte Seite des Stopfens (2) mit Mitteln (9; 11; 14) versehen ist, welche eine kraft- und/oder formschlüssige Verbindung mit dem Abtriebsglied10. stopper (2) of a spray ampoule (3) for dispensing a liquid medicament (4), the stopper (2) having no bore with an internal thread for receiving a pull-up rod, for non-positive and / or positive connection with an output member (1 ) according to any one of claims 1-9, characterized in that the side of the stopper (2) intended for bearing against the driven member (1) is provided with means (9; 11; 14) which are non-positive and / or positive Connection to the output link
(I) ermöglichen, mit Ausnahme einer Gewindeverbindung.(I) allow, with the exception of a threaded connection.
11. Stopfen (2) nach Anspruch 10, dadurch gekennzeichnet, dass die Mittel (9*11*14) einen Magneten (9), einen Klettverschluss11. Stopper (2) according to claim 10, characterized in that the means (9 * 11 * 14) a magnet (9), a Velcro fastener
(II) oder einen Verschlussteil (14) eines Klickverschlusses umfassen.(II) or a closure part (14) of a click closure.
12. Stopfen (2) nach Anspruch 10, dadurch gekennzeichnet, dass die Mittel (9;11;14) einen Klebstoff (7) umfassen, mit dem ein Kraftschluss zwischen Stopfen (2) und Abtriebsglied (1) herstellbar ist. 12. Plug (2) according to claim 10, characterized in that the means (9; 11; 14) comprise an adhesive (7) with which a frictional connection between the plug (2) and the output member (1) can be produced.
PCT/CH1996/000325 1996-09-20 1996-09-20 Expulsion member for advancing the stopper of a syringe ampoule and a corresponding stopper WO1998011927A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
PCT/CH1996/000325 WO1998011927A1 (en) 1996-09-20 1996-09-20 Expulsion member for advancing the stopper of a syringe ampoule and a corresponding stopper

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/CH1996/000325 WO1998011927A1 (en) 1996-09-20 1996-09-20 Expulsion member for advancing the stopper of a syringe ampoule and a corresponding stopper

Publications (1)

Publication Number Publication Date
WO1998011927A1 true WO1998011927A1 (en) 1998-03-26

Family

ID=4550454

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/CH1996/000325 WO1998011927A1 (en) 1996-09-20 1996-09-20 Expulsion member for advancing the stopper of a syringe ampoule and a corresponding stopper

Country Status (1)

Country Link
WO (1) WO1998011927A1 (en)

Cited By (74)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1078643A1 (en) * 1999-08-13 2001-02-28 CANE' S.r.l. Apparatus for administering drugs to a patient
WO2002096487A1 (en) * 2001-05-30 2002-12-05 Acist Medical Systems, Inc. Medical injection system
EP1455870B1 (en) * 2001-12-06 2007-08-08 Novo Nordisk A/S A medical delivery system
EP1897575A2 (en) * 2000-07-20 2008-03-12 ACIST Medical Systems, Inc. Syringe plunger locking mechanism
WO2008103175A1 (en) * 2007-02-22 2008-08-28 M2 Group Holdings, Inc. Portable infusion pump with flexible piston rod
WO2009153544A1 (en) * 2008-06-19 2009-12-23 Cilag Gmbh International Auto- injector with filling means
US8118781B2 (en) 2006-04-19 2012-02-21 Novo Nordisk A/S Fluid infusion system, a method of assembling such system and drug reservoir for use in the system
US8277414B2 (en) 2004-05-28 2012-10-02 Cilag Gmbh International Injection device
US8313465B2 (en) 2004-05-28 2012-11-20 Cilag Gmbh International Injection device
US8313464B2 (en) 2004-05-28 2012-11-20 Cilag Gmbh International Injection device
US8313463B2 (en) 2004-05-28 2012-11-20 Cilag Gmbh International Injection device
US8343110B2 (en) 2004-05-28 2013-01-01 Cilag Gmbh International Injection device
US8551045B2 (en) 2006-04-19 2013-10-08 Novo Nordisk A/S Fluid infusion system, a method of assembling such system and drug reservoir for use in the system
US8834420B2 (en) 2007-05-21 2014-09-16 Asante Solutions, Inc. Illumination instrument for an infusion pump
US8834419B2 (en) 2008-06-19 2014-09-16 Cilag Gmbh International Reusable auto-injector
US8852152B2 (en) 2011-02-09 2014-10-07 Asante Solutions, Inc. Infusion pump systems and methods
US8852141B2 (en) 2007-05-21 2014-10-07 Asante Solutions, Inc. Occlusion sensing for an infusion pump
US8870853B2 (en) 2007-09-06 2014-10-28 Asante Solutions, Inc. Operating a portable medical device
US8894628B2 (en) 2007-09-07 2014-11-25 Asante Solutions, Inc. Activity sensing techniques for an infusion pump system
US8905995B2 (en) 2005-04-06 2014-12-09 Asante Solutions, Inc. Medicine dispensing device
US8939958B2 (en) 2008-06-19 2015-01-27 Cilag Gmbh International Fluid transfer assembly for a syringe
US8945044B2 (en) 2012-07-19 2015-02-03 Asante Solutions, Inc. Infusion pump system and method
US8968236B2 (en) 2005-04-06 2015-03-03 Cilag Gmbh International Injection device
US9028451B2 (en) 2006-06-01 2015-05-12 Cilag Gmbh International Injection device
US9028453B2 (en) 2008-06-19 2015-05-12 Cilag Gmbh International Reusable auto-injector
US9072833B2 (en) 2006-06-01 2015-07-07 Cilag Gmbh International Injection device
US9114209B2 (en) 2005-11-08 2015-08-25 Bigfoot Biomedical, Inc. Method and system for manual and autonomous control of an infusion pump
US9295777B2 (en) 2002-11-05 2016-03-29 Bigfoot Biomedical, Inc. Disposable wearable insulin dispensing device, a combination of such a device and a programming controller and a method of controlling the operation of such a device
US9308319B2 (en) 2002-11-05 2016-04-12 Bigfoot Biomedical, Inc. Wearable insulin dispensing device, and a combination of such a device and a programming controller
US9314569B2 (en) 2005-09-26 2016-04-19 Bigfoot Biomedical, Inc. Dispensing fluid from an infusion pump system
US9358346B2 (en) 2005-08-30 2016-06-07 Cilag Gmbh International Needle assembly for a prefilled syringe system
US9381302B2 (en) 2007-09-07 2016-07-05 Bigfoot Biomedical, Inc. User profile backup system for an infusion pump device
US9415158B2 (en) 2007-09-07 2016-08-16 Bigfoot Biomedical, Inc. Power management techniques for an infusion pump system
US9427523B2 (en) 2012-12-10 2016-08-30 Bigfoot Biomedical, Inc. Infusion pump system and method
US9440021B2 (en) 2007-05-21 2016-09-13 Bigfoot Biomedical, Inc. Removable controller for an infusion pump
US9446187B2 (en) 2013-06-03 2016-09-20 Bigfoot Biomedical, Inc. Infusion pump system and method
US9446186B2 (en) 2013-03-01 2016-09-20 Bigfoot Biomedical, Inc. Operating an infusion pump system
US9457141B2 (en) 2013-06-03 2016-10-04 Bigfoot Biomedical, Inc. Infusion pump system and method
US9517301B2 (en) 2005-09-26 2016-12-13 Bigfoot Biomedical, Inc. Operating an infusion pump system
US9517300B2 (en) 2012-07-20 2016-12-13 Bigfoot Biomedical, Inc. Pump system and method
US9539388B2 (en) 2005-09-26 2017-01-10 Bigfoot Biomedical, Inc. Operating an infusion pump system
US9561324B2 (en) 2013-07-19 2017-02-07 Bigfoot Biomedical, Inc. Infusion pump system and method
US9610404B2 (en) 2011-09-07 2017-04-04 Bigfoot Biomedical, Inc. Method for occlusion detection for an infusion pump system
US9629901B2 (en) 2014-07-01 2017-04-25 Bigfoot Biomedical, Inc. Glucagon administration system and methods
US9649441B2 (en) 2005-04-06 2017-05-16 Cilag Gmbh International Injection device (bayonet cap removal)
US9675757B2 (en) 2004-05-28 2017-06-13 Cilag Gmbh International Injection device
US9675758B2 (en) 2004-05-28 2017-06-13 Cilag Gmbh International Injection device
US9682194B2 (en) 2008-06-19 2017-06-20 Cilag Gmbh International Re-useable auto-injector with filling means
WO2017134144A1 (en) 2016-02-02 2017-08-10 Novo Nordisk A/S Method of forming a medicament cartridge, and medicament cartridge formed by the method
US9731080B2 (en) 2005-04-06 2017-08-15 Cilag Gmbh International Injection device
US9757520B2 (en) 2006-06-01 2017-09-12 Cilag Gmbh International Injection device
US9770558B2 (en) 2005-09-27 2017-09-26 Cilag Gmbh International Auto-injection device with needle protecting cap having outer and inner sleeves
USD809134S1 (en) 2016-03-10 2018-01-30 Bigfoot Biomedical, Inc. Infusion pump assembly
US9878097B2 (en) 2015-04-29 2018-01-30 Bigfoot Biomedical, Inc. Operating an infusion pump system
US9895493B2 (en) 2004-05-28 2018-02-20 Cilag Gmbh International Injection device
US9919096B2 (en) 2014-08-26 2018-03-20 Bigfoot Biomedical, Inc. Infusion pump system and method
US10064993B2 (en) 2005-09-26 2018-09-04 Bigfoot Biomedical, Inc. Dispensing fluid from an infusion pump system
US10137246B2 (en) 2014-08-06 2018-11-27 Bigfoot Biomedical, Inc. Infusion pump assembly and method
USD836769S1 (en) 2016-12-12 2018-12-25 Bigfoot Biomedical, Inc. Insulin delivery controller
USD839294S1 (en) 2017-06-16 2019-01-29 Bigfoot Biomedical, Inc. Display screen with graphical user interface for closed-loop medication delivery
IT201700090397A1 (en) * 2017-08-04 2019-02-04 Medesy Srl SYRINGE FOR DENTISTRY
US10426896B2 (en) 2016-09-27 2019-10-01 Bigfoot Biomedical, Inc. Medicine injection and disease management systems, devices, and methods
US10449294B1 (en) 2016-01-05 2019-10-22 Bigfoot Biomedical, Inc. Operating an infusion pump system
US10569015B2 (en) 2013-12-02 2020-02-25 Bigfoot Biomedical, Inc. Infusion pump system and method
US10709849B2 (en) 2013-06-11 2020-07-14 Cilag Gmbh International Guide for an injection device
US10799646B2 (en) 2013-06-11 2020-10-13 Cilag Gmbh International Injection device
US10987468B2 (en) 2016-01-05 2021-04-27 Bigfoot Biomedical, Inc. Operating multi-modal medicine delivery systems
US11096624B2 (en) 2016-12-12 2021-08-24 Bigfoot Biomedical, Inc. Alarms and alerts for medication delivery devices and systems
US11123492B2 (en) 2013-06-11 2021-09-21 Cilag Gmbh International Injection device
US11173255B2 (en) 2013-06-11 2021-11-16 Cilag Gmbh International Injection device
US11260169B2 (en) 2013-03-14 2022-03-01 Bigfoot Biomedical, Inc. Infusion pump system and methods
US11389088B2 (en) 2017-07-13 2022-07-19 Bigfoot Biomedical, Inc. Multi-scale display of blood glucose information
US11865299B2 (en) 2008-08-20 2024-01-09 Insulet Corporation Infusion pump systems and methods
US11957888B2 (en) 2022-01-11 2024-04-16 Bigfoot Biomedical, Inc. Personalizing preset meal sizes in insulin delivery system

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH268694A (en) * 1950-04-17 1950-05-31 Ag Mediglass Injection syringe and method for making the same.
DE874506C (en) * 1951-10-23 1953-04-23 Bodo Engelberts Injection syringe
US2706984A (en) * 1953-03-19 1955-04-26 Gloacchino Lipari Plunger assembly and disposable medicament cartridge for use therewith
FR1130413A (en) * 1954-09-01 1957-02-05 Hoechst Ag Injection syringe with suction device, for cylindrical ampoules
US4775364A (en) * 1987-07-10 1988-10-04 Anthony Alles Non re-useable disposable hypodermic syringe
GB2202747A (en) * 1987-01-17 1988-10-05 Dr William Ducat Syringes
EP0360313A1 (en) * 1988-08-26 1990-03-28 Advanced Protective Injection Systems B.V. Safety device for an injection syringe needle

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH268694A (en) * 1950-04-17 1950-05-31 Ag Mediglass Injection syringe and method for making the same.
DE874506C (en) * 1951-10-23 1953-04-23 Bodo Engelberts Injection syringe
US2706984A (en) * 1953-03-19 1955-04-26 Gloacchino Lipari Plunger assembly and disposable medicament cartridge for use therewith
FR1130413A (en) * 1954-09-01 1957-02-05 Hoechst Ag Injection syringe with suction device, for cylindrical ampoules
GB2202747A (en) * 1987-01-17 1988-10-05 Dr William Ducat Syringes
US4775364A (en) * 1987-07-10 1988-10-04 Anthony Alles Non re-useable disposable hypodermic syringe
EP0360313A1 (en) * 1988-08-26 1990-03-28 Advanced Protective Injection Systems B.V. Safety device for an injection syringe needle

Cited By (118)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1078643A1 (en) * 1999-08-13 2001-02-28 CANE' S.r.l. Apparatus for administering drugs to a patient
EP1897575A2 (en) * 2000-07-20 2008-03-12 ACIST Medical Systems, Inc. Syringe plunger locking mechanism
EP1897575A3 (en) * 2000-07-20 2008-03-19 ACIST Medical Systems, Inc. Syringe plunger locking mechanism
US7566326B2 (en) 2000-07-20 2009-07-28 Acist Medical Systems, Inc. Syringe plunger locking mechanism
US9901671B2 (en) 2001-05-30 2018-02-27 Acist Medical Systems, Inc. Medical injection system
WO2002096487A1 (en) * 2001-05-30 2002-12-05 Acist Medical Systems, Inc. Medical injection system
US7308300B2 (en) 2001-05-30 2007-12-11 Acist Medical Systems, Inc. Medical injection system
EP1455870B1 (en) * 2001-12-06 2007-08-08 Novo Nordisk A/S A medical delivery system
US9308319B2 (en) 2002-11-05 2016-04-12 Bigfoot Biomedical, Inc. Wearable insulin dispensing device, and a combination of such a device and a programming controller
US9295777B2 (en) 2002-11-05 2016-03-29 Bigfoot Biomedical, Inc. Disposable wearable insulin dispensing device, a combination of such a device and a programming controller and a method of controlling the operation of such a device
US9757512B2 (en) 2002-11-05 2017-09-12 Bigfoot Biomedical, Inc. Wearable insulin dispensing device, and a combination of such a device and a programming controller
US9675757B2 (en) 2004-05-28 2017-06-13 Cilag Gmbh International Injection device
US9895493B2 (en) 2004-05-28 2018-02-20 Cilag Gmbh International Injection device
US8313465B2 (en) 2004-05-28 2012-11-20 Cilag Gmbh International Injection device
US8313464B2 (en) 2004-05-28 2012-11-20 Cilag Gmbh International Injection device
US8313463B2 (en) 2004-05-28 2012-11-20 Cilag Gmbh International Injection device
US8343110B2 (en) 2004-05-28 2013-01-01 Cilag Gmbh International Injection device
US8277414B2 (en) 2004-05-28 2012-10-02 Cilag Gmbh International Injection device
US9675758B2 (en) 2004-05-28 2017-06-13 Cilag Gmbh International Injection device
US9649441B2 (en) 2005-04-06 2017-05-16 Cilag Gmbh International Injection device (bayonet cap removal)
US8968236B2 (en) 2005-04-06 2015-03-03 Cilag Gmbh International Injection device
US10105483B2 (en) 2005-04-06 2018-10-23 Bigfoot Biomedical, Inc. Medicine dispensing device
US8905995B2 (en) 2005-04-06 2014-12-09 Asante Solutions, Inc. Medicine dispensing device
US9731080B2 (en) 2005-04-06 2017-08-15 Cilag Gmbh International Injection device
US9358346B2 (en) 2005-08-30 2016-06-07 Cilag Gmbh International Needle assembly for a prefilled syringe system
US9517301B2 (en) 2005-09-26 2016-12-13 Bigfoot Biomedical, Inc. Operating an infusion pump system
US10064993B2 (en) 2005-09-26 2018-09-04 Bigfoot Biomedical, Inc. Dispensing fluid from an infusion pump system
US9314569B2 (en) 2005-09-26 2016-04-19 Bigfoot Biomedical, Inc. Dispensing fluid from an infusion pump system
US9872957B2 (en) 2005-09-26 2018-01-23 Bigfoot Biomedical, Inc. Operating an infusion pump system
US9814830B2 (en) 2005-09-26 2017-11-14 Bigfoot Biomedical, Inc. Dispensing fluid from an infusion pump system
US10603431B2 (en) 2005-09-26 2020-03-31 Bigfoot Biomedical, Inc. Dispensing fluid from an infusion pump system
US9539388B2 (en) 2005-09-26 2017-01-10 Bigfoot Biomedical, Inc. Operating an infusion pump system
US10307536B2 (en) 2005-09-26 2019-06-04 Bigfoot Biomedical, Inc. Operating an infusion pump system
US9770558B2 (en) 2005-09-27 2017-09-26 Cilag Gmbh International Auto-injection device with needle protecting cap having outer and inner sleeves
US9205192B2 (en) 2005-11-08 2015-12-08 Bigfoot Biomedical, Inc. Method and system for manual and autonomous control of an infusion pump
US9114209B2 (en) 2005-11-08 2015-08-25 Bigfoot Biomedical, Inc. Method and system for manual and autonomous control of an infusion pump
US8118781B2 (en) 2006-04-19 2012-02-21 Novo Nordisk A/S Fluid infusion system, a method of assembling such system and drug reservoir for use in the system
US8551045B2 (en) 2006-04-19 2013-10-08 Novo Nordisk A/S Fluid infusion system, a method of assembling such system and drug reservoir for use in the system
US9028451B2 (en) 2006-06-01 2015-05-12 Cilag Gmbh International Injection device
US9072833B2 (en) 2006-06-01 2015-07-07 Cilag Gmbh International Injection device
US9757520B2 (en) 2006-06-01 2017-09-12 Cilag Gmbh International Injection device
WO2008103175A1 (en) * 2007-02-22 2008-08-28 M2 Group Holdings, Inc. Portable infusion pump with flexible piston rod
US8834420B2 (en) 2007-05-21 2014-09-16 Asante Solutions, Inc. Illumination instrument for an infusion pump
US9440021B2 (en) 2007-05-21 2016-09-13 Bigfoot Biomedical, Inc. Removable controller for an infusion pump
US8852141B2 (en) 2007-05-21 2014-10-07 Asante Solutions, Inc. Occlusion sensing for an infusion pump
US9474854B2 (en) 2007-05-21 2016-10-25 Bigfoot Biomedical, Inc. Occlusion sensing for an infusion pump
US9480793B2 (en) 2007-05-21 2016-11-01 Bigfoot Biomedical, Inc. Occlusion sensing for an infusion pump
US9717849B2 (en) 2007-05-21 2017-08-01 Bigfoot Biomedical, Inc. Occlusion sensing for an infusion pump
US9962482B2 (en) 2007-05-21 2018-05-08 Bigfoot Biomedical, Inc. Removable controller for an infusion pump
US11000645B2 (en) 2007-09-06 2021-05-11 Bigfoot Biomedical, Inc. Operating a portable medical device
US8870853B2 (en) 2007-09-06 2014-10-28 Asante Solutions, Inc. Operating a portable medical device
US10226572B2 (en) 2007-09-06 2019-03-12 Bigfoot Biomedical, Inc. Operating a portable medical device
US9254362B2 (en) 2007-09-07 2016-02-09 Bigfoot Biomedical, Inc. Activity sensing techniques for an infusion pump system
US10226575B2 (en) 2007-09-07 2019-03-12 Bigfoot Biomedical, Inc. Power management techniques for an infusion pump system
US10117993B2 (en) 2007-09-07 2018-11-06 Bigfoot Biomedical, Inc. Activity sensing techniques for an infusion pump system
US9522232B2 (en) 2007-09-07 2016-12-20 Bigfoot Biomedical, Inc. Data storage for an infusion pump system
US10632257B2 (en) 2007-09-07 2020-04-28 Bigfoot Biomedical, Inc. Activity sensing techniques for an infusion pump system
US11241534B2 (en) 2007-09-07 2022-02-08 Bigfoot Biomedical, Inc. Power management techniques for an infusion pump system
US9415158B2 (en) 2007-09-07 2016-08-16 Bigfoot Biomedical, Inc. Power management techniques for an infusion pump system
US9381302B2 (en) 2007-09-07 2016-07-05 Bigfoot Biomedical, Inc. User profile backup system for an infusion pump device
US8894628B2 (en) 2007-09-07 2014-11-25 Asante Solutions, Inc. Activity sensing techniques for an infusion pump system
GB2461087B (en) * 2008-06-19 2012-09-26 Cilag Gmbh Int Injection device
US9682194B2 (en) 2008-06-19 2017-06-20 Cilag Gmbh International Re-useable auto-injector with filling means
US8939958B2 (en) 2008-06-19 2015-01-27 Cilag Gmbh International Fluid transfer assembly for a syringe
WO2009153544A1 (en) * 2008-06-19 2009-12-23 Cilag Gmbh International Auto- injector with filling means
US9028453B2 (en) 2008-06-19 2015-05-12 Cilag Gmbh International Reusable auto-injector
US8834419B2 (en) 2008-06-19 2014-09-16 Cilag Gmbh International Reusable auto-injector
JP2011524766A (en) * 2008-06-19 2011-09-08 シラグ・ゲーエムベーハー・インターナショナル Self-injector with filling means
EA019609B1 (en) * 2008-06-19 2014-04-30 Цилаг Гмбх Интернэшнл Auto-injector with filling means
US11865299B2 (en) 2008-08-20 2024-01-09 Insulet Corporation Infusion pump systems and methods
US8852152B2 (en) 2011-02-09 2014-10-07 Asante Solutions, Inc. Infusion pump systems and methods
US9259529B2 (en) 2011-02-09 2016-02-16 Bigfoot Biomedical, Inc. Infusion pump systems and methods
US9610404B2 (en) 2011-09-07 2017-04-04 Bigfoot Biomedical, Inc. Method for occlusion detection for an infusion pump system
US9545476B2 (en) 2012-07-19 2017-01-17 Bigfoot Biomedical, Inc. Infusion pump system and method
US8945044B2 (en) 2012-07-19 2015-02-03 Asante Solutions, Inc. Infusion pump system and method
US9517300B2 (en) 2012-07-20 2016-12-13 Bigfoot Biomedical, Inc. Pump system and method
US10232108B2 (en) 2012-12-10 2019-03-19 Bigfoot Biomedical, Inc. Infusion pump system and method
US11191891B2 (en) 2012-12-10 2021-12-07 Bigfoot Biomedical, Inc. Infusion pump system and method
US9427523B2 (en) 2012-12-10 2016-08-30 Bigfoot Biomedical, Inc. Infusion pump system and method
US10661007B2 (en) 2013-03-01 2020-05-26 Bigfoot Biomedical, Inc. Operating an infusion pump system
US9446186B2 (en) 2013-03-01 2016-09-20 Bigfoot Biomedical, Inc. Operating an infusion pump system
US11260169B2 (en) 2013-03-14 2022-03-01 Bigfoot Biomedical, Inc. Infusion pump system and methods
US10716895B2 (en) 2013-06-03 2020-07-21 Bigfoot Biomedical, Inc. Infusion pump system and method
US9457141B2 (en) 2013-06-03 2016-10-04 Bigfoot Biomedical, Inc. Infusion pump system and method
US9446187B2 (en) 2013-06-03 2016-09-20 Bigfoot Biomedical, Inc. Infusion pump system and method
US9956339B2 (en) 2013-06-03 2018-05-01 Bigfoot Biomedical, Inc. Infusion pump system and method
US11123492B2 (en) 2013-06-11 2021-09-21 Cilag Gmbh International Injection device
US11173255B2 (en) 2013-06-11 2021-11-16 Cilag Gmbh International Injection device
US10799646B2 (en) 2013-06-11 2020-10-13 Cilag Gmbh International Injection device
US10709849B2 (en) 2013-06-11 2020-07-14 Cilag Gmbh International Guide for an injection device
US9561324B2 (en) 2013-07-19 2017-02-07 Bigfoot Biomedical, Inc. Infusion pump system and method
US10207047B2 (en) 2013-07-19 2019-02-19 Bigfoot Biomedical, Inc. Infusion pump system and method
US11147914B2 (en) 2013-07-19 2021-10-19 Bigfoot Biomedical, Inc. Infusion pump system and method
US10569015B2 (en) 2013-12-02 2020-02-25 Bigfoot Biomedical, Inc. Infusion pump system and method
US11464906B2 (en) 2013-12-02 2022-10-11 Bigfoot Biomedical, Inc. Infusion pump system and method
US10549037B2 (en) 2014-07-01 2020-02-04 Bigfoot Biomedical, Inc. Glucagon administration system and methods
US9629901B2 (en) 2014-07-01 2017-04-25 Bigfoot Biomedical, Inc. Glucagon administration system and methods
US10994078B2 (en) 2014-08-06 2021-05-04 Bigfoot Biomedical, Inc. Infusion pump assembly and method
US10137246B2 (en) 2014-08-06 2018-11-27 Bigfoot Biomedical, Inc. Infusion pump assembly and method
US9919096B2 (en) 2014-08-26 2018-03-20 Bigfoot Biomedical, Inc. Infusion pump system and method
US10661008B2 (en) 2014-08-26 2020-05-26 Bigfoot Biomedical, Inc. Infusion pump system and method
US10603433B2 (en) 2015-04-29 2020-03-31 Bigfoot Biomedical, Inc. Operating an infusion pump system
US11471598B2 (en) 2015-04-29 2022-10-18 Bigfoot Biomedical, Inc. Operating an infusion pump system
US9878097B2 (en) 2015-04-29 2018-01-30 Bigfoot Biomedical, Inc. Operating an infusion pump system
US10449294B1 (en) 2016-01-05 2019-10-22 Bigfoot Biomedical, Inc. Operating an infusion pump system
US10987468B2 (en) 2016-01-05 2021-04-27 Bigfoot Biomedical, Inc. Operating multi-modal medicine delivery systems
WO2017134144A1 (en) 2016-02-02 2017-08-10 Novo Nordisk A/S Method of forming a medicament cartridge, and medicament cartridge formed by the method
USD809134S1 (en) 2016-03-10 2018-01-30 Bigfoot Biomedical, Inc. Infusion pump assembly
US10426896B2 (en) 2016-09-27 2019-10-01 Bigfoot Biomedical, Inc. Medicine injection and disease management systems, devices, and methods
US11229751B2 (en) 2016-09-27 2022-01-25 Bigfoot Biomedical, Inc. Personalizing preset meal sizes in insulin delivery system
US11806514B2 (en) 2016-09-27 2023-11-07 Bigfoot Biomedical, Inc. Medicine injection and disease management systems, devices, and methods
US11096624B2 (en) 2016-12-12 2021-08-24 Bigfoot Biomedical, Inc. Alarms and alerts for medication delivery devices and systems
USD836769S1 (en) 2016-12-12 2018-12-25 Bigfoot Biomedical, Inc. Insulin delivery controller
USD839294S1 (en) 2017-06-16 2019-01-29 Bigfoot Biomedical, Inc. Display screen with graphical user interface for closed-loop medication delivery
USD852837S1 (en) 2017-06-16 2019-07-02 Bigfoot Biomedical, Inc. Display screen with graphical user interface for closed-loop medication delivery
US11389088B2 (en) 2017-07-13 2022-07-19 Bigfoot Biomedical, Inc. Multi-scale display of blood glucose information
IT201700090397A1 (en) * 2017-08-04 2019-02-04 Medesy Srl SYRINGE FOR DENTISTRY
US11957888B2 (en) 2022-01-11 2024-04-16 Bigfoot Biomedical, Inc. Personalizing preset meal sizes in insulin delivery system

Similar Documents

Publication Publication Date Title
WO1998011927A1 (en) Expulsion member for advancing the stopper of a syringe ampoule and a corresponding stopper
DE102004042581B4 (en) Auto-Pen for dual-chamber ampoule
DE60037531T2 (en) MEDICATION CARTRIDGE AND INJECTION DEVICE
EP0525525B1 (en) Injector
DE4434644C2 (en) Container for the storage and administration of injection, infusion and diagnostic preparations
DE10330094B4 (en) Device for administering a liquid product
EP1742688B1 (en) Injection device comprising a dosing unit with multiple anti-twist protection
EP0709104B1 (en) Injection device
EP0144625B1 (en) Injection device
EP0373321B1 (en) Reusable injection device for the delivery of a preselected dose
EP2050477B1 (en) Ampoule unit with adapter
DE1491788A1 (en) Injector for medication
DE8509572U1 (en) Dispensing device, in particular medical syringe, for dispensing predetermined, consecutive amounts of medicine
EP3626289A1 (en) Injection device comprising an improved delivery element
WO2009049885A1 (en) Injection device with reset of the piston rod caused by cartridge exchange
WO2000007647A1 (en) Ready-to-use syringe for unstable drugs
DE2259825B2 (en) Injection device
WO2015172828A1 (en) Spindle device for a piston of a reservoir with medicament fluid
EP1567215B1 (en) Device for screwing together medium-guiding threaded connections, particularly luer lock connections
WO2016071483A1 (en) Medicament device
DE102004055298A1 (en) Device for mixing injected medicine comprises an ampoule sleeve, a mixing sleeve, an abutment and a guiding unit having a power transmission structure which converts a linear into a rotary movement
CH397157A (en) Injection syringe
WO2006061067A1 (en) Adapter for an injection device
DE1083506B (en) Injection device
DE1491819C (en) Chip rack arrangement

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A1

Designated state(s): US

AL Designated countries for regional patents

Kind code of ref document: A1

Designated state(s): AT BE CH DE DK ES FI FR GB GR IE IT LU MC NL PT SE

DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
121 Ep: the epo has been informed by wipo that ep was designated in this application
NENP Non-entry into the national phase

Ref country code: CA

122 Ep: pct application non-entry in european phase