WO1997037617A1 - Extenseurs interconnectes multiples et leur procede de revetement - Google Patents

Extenseurs interconnectes multiples et leur procede de revetement Download PDF

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Publication number
WO1997037617A1
WO1997037617A1 PCT/US1997/006098 US9706098W WO9737617A1 WO 1997037617 A1 WO1997037617 A1 WO 1997037617A1 US 9706098 W US9706098 W US 9706098W WO 9737617 A1 WO9737617 A1 WO 9737617A1
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WO
WIPO (PCT)
Prior art keywords
stent
coating
stents
mandrel
slots
Prior art date
Application number
PCT/US1997/006098
Other languages
English (en)
Inventor
Swaminathan Jayaraman
Original Assignee
Swaminathan Jayaraman
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/629,318 external-priority patent/US5725548A/en
Priority claimed from US08/689,290 external-priority patent/US5713949A/en
Application filed by Swaminathan Jayaraman filed Critical Swaminathan Jayaraman
Priority to CA002250954A priority Critical patent/CA2250954C/fr
Priority to EP97921162A priority patent/EP1006938A4/fr
Priority to AU27280/97A priority patent/AU729119B2/en
Publication of WO1997037617A1 publication Critical patent/WO1997037617A1/fr

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Classifications

    • BPERFORMING OPERATIONS; TRANSPORTING
    • B29WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29CSHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C31/00Handling, e.g. feeding of the material to be shaped, storage of plastics material before moulding; Automation, i.e. automated handling lines in plastics processing plants, e.g. using manipulators or robots
    • B29C31/002Handling tubes, e.g. transferring between shaping stations, loading on mandrels
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/82Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/86Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure
    • A61F2/90Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure
    • A61F2/91Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/82Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/86Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure
    • A61F2/90Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure
    • A61F2/91Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes
    • A61F2/915Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes with bands having a meander structure, adjacent bands being connected to each other
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B29WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29CSHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C41/00Shaping by coating a mould, core or other substrate, i.e. by depositing material and stripping-off the shaped article; Apparatus therefor
    • B29C41/02Shaping by coating a mould, core or other substrate, i.e. by depositing material and stripping-off the shaped article; Apparatus therefor for making articles of definite length, i.e. discrete articles
    • B29C41/14Dipping a core
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B29WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29CSHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C41/00Shaping by coating a mould, core or other substrate, i.e. by depositing material and stripping-off the shaped article; Apparatus therefor
    • B29C41/02Shaping by coating a mould, core or other substrate, i.e. by depositing material and stripping-off the shaped article; Apparatus therefor for making articles of definite length, i.e. discrete articles
    • B29C41/20Shaping by coating a mould, core or other substrate, i.e. by depositing material and stripping-off the shaped article; Apparatus therefor for making articles of definite length, i.e. discrete articles incorporating preformed parts or layers, e.g. moulding inserts or for coating articles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/0077Special surfaces of prostheses, e.g. for improving ingrowth
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/95Instruments specially adapted for placement or removal of stents or stent-grafts
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/95Instruments specially adapted for placement or removal of stents or stent-grafts
    • A61F2/958Inflatable balloons for placing stents or stent-grafts
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02Prostheses implantable into the body
    • A61F2/04Hollow or tubular parts of organs, e.g. bladders, tracheae, bronchi or bile ducts
    • A61F2/06Blood vessels
    • A61F2/07Stent-grafts
    • A61F2002/072Encapsulated stents, e.g. wire or whole stent embedded in lining
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/82Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2002/828Means for connecting a plurality of stents allowing flexibility of the whole structure
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/82Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/86Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure
    • A61F2/90Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure
    • A61F2/91Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes
    • A61F2/915Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes with bands having a meander structure, adjacent bands being connected to each other
    • A61F2002/9155Adjacent bands being connected to each other
    • A61F2002/91558Adjacent bands being connected to each other connected peak to peak
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2220/00Fixations or connections for prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2220/0025Connections or couplings between prosthetic parts, e.g. between modular parts; Connecting elements
    • A61F2220/005Connections or couplings between prosthetic parts, e.g. between modular parts; Connecting elements using adhesives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2220/00Fixations or connections for prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2220/0025Connections or couplings between prosthetic parts, e.g. between modular parts; Connecting elements
    • A61F2220/0058Connections or couplings between prosthetic parts, e.g. between modular parts; Connecting elements soldered or brazed or welded
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2220/00Fixations or connections for prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2220/0025Connections or couplings between prosthetic parts, e.g. between modular parts; Connecting elements
    • A61F2220/0075Connections or couplings between prosthetic parts, e.g. between modular parts; Connecting elements sutured, ligatured or stitched, retained or tied with a rope, string, thread, wire or cable
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2310/00Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
    • A61F2310/00389The prosthesis being coated or covered with a particular material
    • A61F2310/00976Coating or prosthesis-covering structure made of proteins or of polypeptides, e.g. of bone morphogenic proteins BMP or of transforming growth factors TGF
    • A61F2310/00982Coating made of collagen
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2310/00Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
    • A61F2310/00389The prosthesis being coated or covered with a particular material
    • A61F2310/00976Coating or prosthesis-covering structure made of proteins or of polypeptides, e.g. of bone morphogenic proteins BMP or of transforming growth factors TGF
    • A61F2310/00994Coating made of gelatin

Definitions

  • the present invention relates to multiple interconnected stents, a covered microporous stent and method of coating.
  • Coated stents are known as stents that are designed to expand at the site within a blood vessel where they are intended to engage the internal wall of the blood vessel to reinforce it.
  • stents In using stents it is often the case that the area where repair and/or reinforcement is required extends around one or more curves in a tortious path. Under such circumstances, a single stent will not adequately perform the job of strengthening and reinforcing the blood vessel. Since the individual stent must be made of a rigid construction to perform its reinforcing task, where a tortious path of a blood vessel must be strengthened and/or reinforced, a plurality of stents must be interconnected together to cover the entire length of the area where rein orcement is necessary.
  • Restenosis can be caused by incompatibility of the metallic surface of the stent that engages the inner walls of the blood vessel giving rise to subacute thrombosis, usually within four weeks of implantation of the stent.
  • Another possible cause of restenosis is the recoil of the metallic surface of the stent when placed along the internal wall of the artery. Such recoil does not occur immediately, but, rather, when the stent pulses due to its elastic nature, stresses act downwardly toward the stent resulting in gradual diminishing of the luminal diameter.
  • stents have an open mesh area when they are expanded and rapid ingrowth of collagen cells and smooth muscle cells gradually occurs through these open areas. Collagen cells contributing toward intimal hyperplasia eventually result in the narrowing of the lumen diameter. Additionally, sometimes, at the location where the stent is to be placed, such as, for example, in saphenous vein grafts, thrombus exists that must be bypassed. Finally, in the aorta and peripheral arteries, a large portion of the aneurysmal sac may have to be bypassed prior to stent implantation.
  • Use of polymeric or biologic material to coat a stent is generally known.
  • the coefficient of expansion of the coating greatly differs from that of the expanding stent such that, upon expansion, the surface of the coating tears rendering the expanded stent uncoated. If, as a solution, the coating is applied more thickly, such a thick coating can deter stent expansion or can have such a high profile that implantation into the body is difficult. The same problem occurs when a stent is coated by sandwiching it between inner and outer coating layers. If the stent cannot be expanded to its full intended diameter, the success of the implantation can be drastically compromised.
  • the prior art also describes biologic coatings such as collagen gelatin to be employed on a balloon expandable or thermally expandable stent. To coat such a stent, it is placed in a mandrel and then dipped into the biologic solution and then dried in an oven. Applicant is unaware of the nature of the resulting properties of the stent when expanded.
  • stents have been coated with a polymeric material such as silicone that renders the resulting stent impervious to any incursion of biologic tissue.
  • a polymeric material such as silicone that renders the resulting stent impervious to any incursion of biologic tissue.
  • the impervious nature of the coating deters the healing of the surrounding tissues.
  • the present invention relates to embodiments of multiple interconnected stents.
  • a plurality or multiplicity of stents are interconnected together by interconnection means to form an elongated multiple stent configuration.
  • each stent is made from a rectangular piece of material formed in a roll with the facing edges fused together by means such as plasma energy fusing, LASER, ultrasound, or any other suitable means.
  • Each stent so formed includes a configuration consisting of multiple rows of slots spaced by spaces with each space being staggered with respect to spaces of adjacent rows.
  • adjacent stents are interconnected by a single flexible resilient bar.
  • adjacent stents are interconnected by means of U-shaped members fused together.
  • adjacent stents are interconnected by an integral piece of material having slots extending orthogonal to the slots in the adjacent stents.
  • adjacent stents are interconnected by means of flexible resilient bars. However, different pairs of interconnected stents have bars vertically staggered with respect to other pairs of interconnected stents.
  • adjacent stents are interconnected by virtue of a plurality of vertically spaced connectors resembling the letter "H".
  • adjacent stents are interconnected by a multiplicity of vertically spaced elongated flexible resilient bars.
  • adjacent stents are interconnected by virtue of a multiplicity of flexible resilient members resembling the letter "W" .
  • the stents as interconnected together may be expanded within a blood vessel through the use of means such as, for example, a balloon catheter or a mechanical spreader.
  • the present invention also relates to a polymer or biological material coated microporous stent and method of coating.
  • the present invention includes the following additional interrelated objects, aspects and features:
  • a coating is attached to the stent only at a single area of line contact on the outer surface of the stent with the remainder of the coating being larger than the unexpanded stent, but being made of dimensions designed to snugly receive the outer surfaces of the stent when it is expanded within a blood vessel.
  • the unexpanded stent is placed over a mandrel and is then inserted within an elongated recess eccentrically located within a larger mandrel with the recess having an elongated opening on a peripheral edge thereof.
  • the coating surrounds the outer mandrel and connects with the stent only at the area of the peripheral linear opening.
  • the mandrels are removed, what remains is the stent having an enlarged coating attached thereto only at one linear elongated location.
  • the present invention also contemplates coating of a stent of the type known as a "self-expanding" stent that is programmed to self-expand at a particular temperature by either using the shape memory properties of the metal or by using the flexibility and elasticity of the metal.
  • a stent of the type known as a "self-expanding" stent that is programmed to self-expand at a particular temperature by either using the shape memory properties of the metal or by using the flexibility and elasticity of the metal.
  • the stent prior to programming the formed stent, the stent is placed in a container of coating material and is coated. Thereafter, the stent is programmed in the desired manner and is subsequently physically compressed and kept inside a sheath. The stent is placed within the blood vessel still within the sheath, and the sheath is then removed, allowing the stent to expand to its desired configuration.
  • the present invention is intended to fulfill the following objects, aspects and features:
  • the coating so developed has the property of microporosity that facilitates controlled ingrowth of tissue within the coating to provide a neoinitimal healing mechanism.
  • the coating may be provided with specific substances that are designed to enhance the healing properties of the stent.
  • the wall thickness of the coating is intended to be extremely thin, on the order of 5 to 80 mils in thickness. For larger diameters the thickness of the coating can be up to 100 mils thick.
  • the coating provides a conduit for dilatation of the plaque, can bypass a thrombus or eliminate an aneurysmal sac.
  • the length of the coating and the stent may be varied so that the stent runs some or all of the entire length of the microporous coating. Additionally, if desired, the stent may be intermittently placed within the coating or may be placed at only the proximal and distal ends thereof.
  • Figure 1 shows a top view of a first embodiment of the present invention before the rectangular pieces are rolled and fused to form the multiple stents.
  • Figure 2 shows a side view of the embodiment of Figure 1 after the stents have been formed.
  • Figure 3 shows an enlarged side view similar to that of Figure 2.
  • Figure 4 shows a side view of a second embodiment of the present invention.
  • Figure 5 shows a side view of a third embodiment of the present invention.
  • Figure 6 shows a side view of a fourth embodiment of the present invention.
  • Figure 7 shows a side view of a fifth embodiment of the present invention.
  • Figure 8 shows a side view of a sixth embodiment of the present invention.
  • Figure 9 shows a side view of a seventh embodiment of the present invention.
  • Figure 10 shows a side view, partially in cross-section, of a multiple stent in accordance with the teachings of the present invention as it is being inserted within a blood vessel.
  • Figure 11 shows a further side view of a stent attached over an insertion mechanism.
  • Figure 12 shows a cross-sectional view along the line 12-12 of Figure 11.
  • Figure 13 shows a view similar to that of Figure 12 but with the stent expanded.
  • Figure 14 shows a view similar to Figure 12 of a different stent configuration.
  • Figure 15 shows a view similar to that of Figure 13 with the stent of Figure 14 expanded.
  • Figures 16 and 17 show an expanding mechanism in the expanded and closed configurations, respectively.
  • FIG 18 shows further details of the mechanical expanding mechanism shown in Figures 16 and 17.
  • Figure 19 shows a top view of a flat piece of material intended to be formed into a single stent.
  • Figure 20 shows a perspective view of the material shown in Figure 1 formed into a single stent.
  • Figure 21 shows an exploded perspective view of the stent shown in Figure 20 with relation to a solid plastic mandrel over which it is to be placed.
  • Figure 22 shows the stent placed over the mandrel of Figure 21.
  • Figures 23 and 24 show the process of placing the stent and mandrel of Figure 22 within a recess of a larger mandrel.
  • Figure 25 shows a cross-sectional view along the line 25-25 of Figure 24 after the coating process has taken place.
  • Figure 26 shows the process of removing the coated stent from the larger mandrel.
  • Figure 27 shows a cross-sectional view along the line 27-27 of Figure 26.
  • Figures 28 and 29 show top views of two additional different embodiments of stents made up of a plurality of stent sections interconnected together.
  • Figure 30 shows a side view of the configuration of the stent and mandrels shown in Figure 24.
  • Figure 31 shows a side view of an alternative process wherein two stents are coated on a single mandrel.
  • Figure 32 shows a side view of the practicing of a further process wherein three spaced stents are coated on a single mandrel.
  • Figure 33 shows the process of inserting a balloon catheter within the coated stent.
  • Figure 34 shows the balloon catheter within the stent with the outer coating wrapped closely therearound for insertion.
  • Figures 35 and 36 show an exploded perspective view and a perspective view, respectively, of the process for attaching a stent over a mandrel in a further process in accordance with the teachings of the present invention.
  • Figure 37 shows a plurality of mandrels and stents corresponding to Figures 35 and 36 and suspended within a bath of coating material within a tank.
  • Figure 38 shows the stents of Figure 37, after coating, and placed within an oven to dry the coating material.
  • Figure 39 shows a side view of a stent coated in accordance with the teachings of the process illustrated in Figures 35-38.
  • Figures 40-42 show the sequential process for inserting the stent, coated in accordance with the process illustrated in Figures 35-38 within a blood vessel.
  • FIG. 1 shows the first embodiment 10 prior to forming of the stents from generally rectangular pieces 11 shown in the figure.
  • each stent is formed from a rectangular piece such as the rectangular piece 11.
  • these rectangular pieces will be referred to using the reference numeral 11.
  • each rectangular piece 11 has a top edge 13 and a bottom edge 15 as well as side edges 17 and 19.
  • Each rectangular piece 11 has a body 12 that includes a multiplicity of rows 14, 16 of slots 18, 8, respectively, with the slots 18 being separated by spaces 21 and with the slots 8 being separated by spaces 23.
  • the spaces 21, 23 are staggered with respect to one another in adjacent rows 14, 16. This configuration of slots and spaces is employed in each of the embodiments of the present invention.
  • adjacent pieces 11 forming stents are interconnected by virtue of flexible resilient bars 25. As seen in Figure 1, in particular, the bars 25 are co-linear.
  • the rectangular piece 11 or tubular welded metal sheet used to form the stents is manufactured by using a laser cutting tool to prepare the slots 18 and 8 in either a sheet of metal or plastic.
  • the laser tool cuts out each of the slots 18 and 8 from a preprogrammed pattern.
  • Other methods of cutting can be employed such as photochemical etching, water jet cutting and similar mechanisms where energy in different forms are applied for cutting of the flat metal sheet or a tubular welded metal sheet.
  • the metal can be stainless steel, titanium, nickel, a thermal alloy such as NITINOL or other metal compatible with a patient's vascular tissue.
  • the body 12 is formed into a roll and the edges 13 and 15 are fused together by any suitable means such as plasma energy fusing, LASER fusing, ultrasound fusing. This feature is in common with all of the embodiments of the present invention.
  • the body can be formed in a roll and fused together before forming the slots over a solid tubular structure.
  • the multiple stent 10 or individual stent as shown in Figures 19 and 20 may be coated, in a first inventive process, in the manner described with reference to Figures 21-27.
  • the stent 10 may be placed over a solid plastic or metal generally cylindrical mandrel 115 so that the inner surface 111 of the stent 10 snugly engages the outer surface 117 of the mandrel 115 in the manner seen in Figures 25 and 27.
  • the stent 10 and mandrel 115 may be placed within the recess 125 of a second, larger mandrel 120 having a large generally cylindrical outer surface 121.
  • the recess 125 is generally cylindrical in nature and is eccentrically placed with respect to the body of the second mandrel 120 so that the recess 125 intersects with the periphery of the mandrel 20 at an elongated slot 123 extending throughout the longitudinal length of the second mandrel 120.
  • Figure 24 shows the stent 10, the first inner mandrel 115 and the second mandrel 120 as assembled together.
  • the entire assembly is dipped in a bath of coating material so that, as best seen in Figure 25, a coating 130 is formed about the periphery of the mandrel 120 and attaches to the stent 10 at the area designated by the reference numeral 131 in Figure 25 that corresponds to the location of the elongated slot 123 within the mandrel 120.
  • the slot 123 permits covering material to enter the recess 125 in the mandrel 120 in an elongated path along the longitudinal length of the stent 10 at one location therealong to affix the coating 130 thereto. Otherwise, the unexpanded stent 10 is uncoated.
  • Figure 30 shows a side view of the assembly of the coated stent 10 and the mandrels 115 and 120 as seen in Figure 24.
  • Figure 26 shows removal of the stent 10, the mandrel 115 and the coating 130 from the mandrel 120. If necessary, a lubricant may be employed for this purpose.
  • the cross-sectional view of Figure 27 shows the stent 10 with the coating 130 spaced therefrom except at the area designated by the reference numeral 131 where the coating 130 is firmly attached to the stent 10. Subsequently, the mandrel 115 is removed from the interior of the stent 10.
  • the coated stent 10 is used by inserting a balloon catheter 135 snugly within the unexpanded stent 10 and by loosely wrapping the coating 130 about the stent 10 so that the configuration is small enough to be easily inserted within a blood vessel as shown in Figure 34.
  • the balloon catheter 35 is expanded in a manner well known to those skilled in the art, the stent 10 expands so that the outer surface 112 thereof peripherally engages the inner surface 133 of the coating 130 so that, in the expanded state, the stent 10 is fully covered with a coating that has complete integrity.
  • Figure 28 shows a plurality of flat pieces la, lb and lc interconnected together by resilient flexible connectors 40, each of which consists of a series of rows of generally "X"-shaped members fixed together as shown.
  • the device shown in Figure 10 may be assembled into a triple stent by forming the entire assembly into a roll as understood with reference to Figures 1 and 2.
  • Figure 29 shows an assembly 50 that consists of regions 151, 153 and 159, each one of which corresponds to the flat piece of material 1 as seen in Figure 1.
  • the members 151 and 153 are interconnected together by the connecting portion 157 while the members 153 and 159 are interconnected together by the connecting portion 155.
  • the device 150 illustrated in Figure 29 may be assembled into a triple stent, again, in the manner that should be understood from Figures 1 and 2.
  • the connecting portions 157 and 155 allow longitudinal expansion of the length of the device 150 in the directions of the double headed arrow 161.
  • the flat piece of material 1, la, lb or lc is manufactured by using a laser cutting tool to prepare the slots in rows 6 and 7 of Figure 19 in either a sheet of metal or plastic.
  • the laser tool cuts out each of the slots for rows 6 and 7 from a preprogrammed pattern.
  • the metal can be stainless steel, titanium, nickel, a thermal alloy such as NITNOL or other metal compatible with a patient's vascular tissue.
  • the coating 30 is a biocompatible material such as polyurethane, polyethylene, polytetrafluroethylene, silicone, block co-polymers of polyurethane, polyethylene and silicone, a biodegradable polymer such as polylactic acid, polyglycollic acid, and or hydroxy butyrate or valerate co-polymer. Biocompatible material will not interfere with blood or blood vessel interior wall tissue.
  • the polymers can include anticoagulant agents, growth factor and like agents for reducing the reaction of blood to foreign surfaces.
  • Plastics employed to make the flat piece of material 1, la, lb or lc can be polyethylene, polyurethane, polytetrafluroethylene, silicone or copolymer of polyurethane and polyethylene compatible with the vascular tissue of a patient.
  • Figure 21 shows the use of the mandrel 120 to provide coatings 130a and 130b on two stents 10a and 10b.
  • Figure 32 shows the use of the mandrel 120 to create three coatings 130a, 130b and 130c on respective stents 10a, 10b and 10c.
  • a stent 170 is shown that is of the type that is known as "self-expandable" .
  • Such a stent is programmed to self- expand at a particular temperature either by using the shape memory properties of the metal or by using the inherent flexibility and elasticity thereof.
  • the stent 170 as depicted in Figures 35 and 36 is shown prior to the programming step.
  • a mandrel 71 is inserted within the stent 170.
  • one or more stents 170 are dipped in a container 173 containing a liquid coating with the mandrels 171 being supported on a support 175 in a manner that should be well understood.
  • the container 173 may contain a polymeric coating material.
  • the stents 170 are placed within an oven 180 having an internal chamber 181 with a heating element 183 connectable to a source of power (not shown).
  • the stents 170 are heated to a desired temperature for a desired period of time and excess solvents are removed during the heating process.
  • the suitably coated stent 170 with the coating 172 thereon is seen in Figure 39.
  • the stent 170 is suitably programmed.
  • the stent 170 may be dipped into a cold bath at a desired temperature and retained under cool temperature for a period of time so that when it is exposed to body temperature it expands to a desired degree of expansion.
  • the stent is physically compressed.
  • the stent in the compressed state, the stent is covered with a non-expansible sheath 85 that prevents expansion until expansion is desired.
  • Figure 40 shows the stent 170 encased within the sheath 185 and inserted using an appropriate mechanism 187 into a blood vessel at an appropriate location.
  • the sheath 185 is then removed and, with reference to Figure 42, the stent 170 expands either due to its inherent elasticity or due to exposure to body temperature within the blood vessel and performs its function.
  • the process illustrated in Figures 35-38 also may be employed in coating the stent employing the mandrels as illustrated in Figures 21-27.
  • the polymeric coating solution contains a solvent.
  • the solvent may suitably be removed by heat (as explained with reference to Figure 38), by vacuum or through the use of a non-solvent. If desired, several dips into the tank 173 may be carried out to provide the desired final wall thickness of the coating.
  • the portion 131 of the coating where it attaches about the stent 10 may be reinforced with a line of sutures.
  • the conduit may be slipped onto the eccentric mandrel 20 and may be attached to the stent by welding, adhesive or by a line of sutures.
  • Conduits that may be employed in this regard include those made of polyurethane, expanded polytetraflorol ethylene (TEFLON) , extruded TEFLON, polyester which may be knit or woven, velour or non-velour, extruded, PET, PE, hydrogels that can impart a desirable elastic nature to the walls of the coating. These choices are merely given by way of example.
  • the coating material may be solvent based, extruded or biological and may be assembled to the mandrel and attached to the "self-expanding" stent either by a continuous suture or intermittently placed sutures along one axis of the stent or by an adhesive or any other mechanical, thermal or chemical treatment that ensures attachment.
  • the stent and the coating material are together programmed to expand at body temperature.
  • the stent and coating may be dipped in a cold bath with the coating attached to reduce them both to a much smaller size which may then be inserted into a sheath which may be removed within the body to allow expansion to the expanded size when the coating was originally applied.
  • a second embodiment of multiple interconnected stents is designated by the reference numeral 20 and includes a plurality of pieces 11 forming stents as explained above. Adjacent stents are interconnected by virtue of U-shaped members 27, 29 that are fused together at various points and interconnected to each stent as shown in Figure 4. These interconnectors 27, 29 are flexible and resilient.
  • Figure 5 shows a third embodiment of the present invention generally designated by the reference numeral 30 and including a plurality of rectangular pieces 11 formed in a single sheet 31 integrally incorporating interconnectors 33, each of which consists of a plurality of rows 35, 37 of slots 36, 38 with each row of slots 36, 38 having spaces 39 between adjacent slots that are staggered in adjacent rows.
  • the slots 36, 38 are orthogonal to the slots 8 and 18 of the rectangular piece 11.
  • Figure 6 shows a fourth embodiment of the present invention generally designated by the reference numeral 40 and including a plurality of pieces 11 interconnected by double bars 41, 43.
  • These double bars 41, 43 are similar to the single bars 25 in the first embodiment illustrated in Figures 1-3. However, as seen in Figure 6, different sets of double bars 41, 43 are vertically staggered with respect to one another.
  • Figure 7 shows a fifth embodiment of the present invention generally designated by the reference numeral 50 and including a plurality of pieces 11 interconnected by interconnectors 51 consisting of a plurality of vertically spaced connectors 53, each resembling the letter "H” with additional horizontal legs 55 connecting the "H"-shaped connector 53 to each piece 11.
  • Figure 8 shows a sixth embodiment of the present invention generally designated by the reference numeral 60 and including a plurality of pieces 11 with adjacent pieces 11 being interconnected by a multiplicity of vertically spaced bars 61.
  • This embodiment is similar to the embodiment of Figures 1-3 except that a multiplicity of bars 61 are employed instead of the single bars 25 of the Figures 1-3 embodiment.
  • Figure 9 shows a seventh embodiment of the present invention generally designated by the reference numeral 70 and including a plurality of pieces 11 interconnected together by a plurality of vertically spaced interconnectors 71, each one of which is flexible and resilient and resembles the letter "W" .
  • a short lateral section 73 is provided to connect the connector 71 to each adjacent piece 11.
  • Figure 10 shows a side view, partially in cross-section, of the multiple stent 10 of the embodiment of Figures 1-3 as contained within a blood vessel 1.
  • An appliance 80 is shown inserted through the pieces 11 to convey the entire multiple stent 10 to a desired location within the blood vessel 1.
  • Figure 11 shows the device 80 which is better seen with reference to Figures 12, 13, 16, 17 and 18.
  • the device 80 includes a plurality of expander blocks 81 mounted on a spreader mechanism 83 including legs 85, 87 pivoted together at a pivot 89 and interconnected to an actuator mechanism 91 at the pivots 93.
  • a wire 95 extends through the tube 97 and connects to the actuator 91 whereby when the wire 95 is pulled in the direction of the arrow 99, the actuator 91 moves to the right in the view of Figure 18 to cause separation of the blocks 81 to the position shown in Figures 13 and 18 whereby the stent 10 is expanded to engage the walls 3 of the blood vessel 1.
  • FIG. 16 and 17 Other views of the device 80 are also seen in Figures 16 and 17 with Figures 14 and 15 showing an alternative insertion device 100 having eight blocks 101 rather than the four blocks 81 of the device 80.
  • the insertion device 100 spreads the forces of enlargement of the stents 10 more uniformly around the circumference thereof.
  • the stents employed in this invention are about 1.5-2.5 mm in length and the interconnections about 0.30 mm to 0.60 mm in length.
  • the total length of an interconnected stent is 5 mm to 60 mm in length to form segments of the rigid slotted stents and flexible interconnections.

Abstract

L'invention se rapporte à des extenseurs interconnectés, à des extenseurs interconnectés poreux et à leur procédé de revêtement. L'extenseur (10) de l'invention comprend un élément tubulaire (11) interconnecté à un autre élément tubulaire (11) avec un élément flexible (25), chaque extenseur étant constitué d'une feuille plate assemblée par une technique telle que la fusion de surface. De préférence, l'extenseur est constitué d'une pluralité de rangées de fentes présentant des espaces entre des fentes adjacentes dans une rangée décalée par rapport aux espaces correspondants des rangées adjacentes. Selon un premier mode de réalisation de revêtement d'un extenseur, le revêtement est fixé à l'extenseur au niveau d'une zone de contact linéaire unique (130) sur la surface externe de l'extenseur, le reste du revêtement étant plus grand que la surface de l'extenseur non déployé, ses dimensions lui permettant cependant de recevoir, selon un ajustement serré, les surfaces externes de l'extenseur lorsque ce dernier est déployé dans un vaisseau sanguin.
PCT/US1997/006098 1996-04-08 1997-04-04 Extenseurs interconnectes multiples et leur procede de revetement WO1997037617A1 (fr)

Priority Applications (3)

Application Number Priority Date Filing Date Title
CA002250954A CA2250954C (fr) 1996-04-08 1997-04-04 Methode de revetement de stents
EP97921162A EP1006938A4 (fr) 1996-04-08 1997-04-04 Extenseurs interconnectes multiples et leur procede de revetement
AU27280/97A AU729119B2 (en) 1996-04-08 1997-04-04 Multiple interconnected stents and method of coating stents

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US08/629,318 1996-04-08
US08/629,318 US5725548A (en) 1996-04-08 1996-04-08 Self-locking stent and method for its production
US69257096A 1996-08-06 1996-08-06
US08/689,290 US5713949A (en) 1996-08-06 1996-08-06 Microporous covered stents and method of coating
US08/692,570 1996-08-06
US08/689,290 1996-08-06

Publications (1)

Publication Number Publication Date
WO1997037617A1 true WO1997037617A1 (fr) 1997-10-16

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EP (1) EP1006938A4 (fr)
AU (1) AU729119B2 (fr)
CA (1) CA2250954C (fr)
WO (1) WO1997037617A1 (fr)

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EP0970711A2 (fr) * 1998-06-30 2000-01-12 Ethicon, Inc. Procédé de revêtement d'extenseurs vasculaires
FR2785174A1 (fr) * 1998-11-03 2000-05-05 Jacques Seguin Extenseur de conduit corporel, notamment vasculaire
EP1005843A3 (fr) * 1998-12-03 2000-09-20 Medinol Ltd. Ensemble de stents à détachement controlé
WO2000062708A1 (fr) * 1999-04-15 2000-10-26 Mayo Foundation For Medical Education And Research Extenseur multisection
WO2001021101A1 (fr) * 1999-09-22 2001-03-29 Andrei Vladimirovich Karev Extenseur souple expansible et procede de fabrication correspondant
EP1029517A3 (fr) * 1999-01-14 2001-08-01 Medtronic Inc. Stent endoluminal à structure décalée
EP0997116B1 (fr) * 1998-10-26 2003-06-11 Medinol Ltd. Stent recouvert, déployable par gonflement d'un ballon
US6796999B2 (en) 2001-09-06 2004-09-28 Medinol Ltd. Self articulating stent
US6913762B2 (en) 2001-04-25 2005-07-05 Mayo Foundation For Medical Education And Research Stent having non-woven framework containing cells
EP1598031A2 (fr) 1998-03-04 2005-11-23 Boston Scientific Limited Extenseur ayant des propriétés variables
JP2008279278A (ja) * 2002-04-24 2008-11-20 Biosensors Internatl Group Ltd 薬物送達脈管内ステントおよび再狭窄を処置するための方法
WO2009091855A1 (fr) * 2008-01-17 2009-07-23 Boston Scientific Scimed, Inc. Système et procédé de déploiement d'un dispositif médical auto-extensible avec revêtement
WO2010092065A1 (fr) 2009-02-11 2010-08-19 INSERM (Institut National de la Santé et de la Recherche Médicale) Endoprothèse pour lésions cartilagineuses
US8252046B2 (en) 2002-04-24 2012-08-28 Biosensors International Group, Ltd. Drug-delivery endovascular stent and method for treating restenosis
WO2012164294A1 (fr) * 2011-06-03 2012-12-06 Vascutek Limited Élément d'endoprothèse
WO2014158580A3 (fr) * 2013-03-14 2015-05-07 W.L. Gore & Associates, Inc. Méthodes et appareil d'assemblage d'endoprothèses-greffons
US9039755B2 (en) 2003-06-27 2015-05-26 Medinol Ltd. Helical hybrid stent
US9155639B2 (en) 2009-04-22 2015-10-13 Medinol Ltd. Helical hybrid stent
US9398964B2 (en) 2011-06-03 2016-07-26 Vascutek Limited Device for securing a prosthesis to the internal wall of a body lumen
US9456910B2 (en) 2003-06-27 2016-10-04 Medinol Ltd. Helical hybrid stent
US9622894B2 (en) 2011-06-03 2017-04-18 Vascutek Limited Apparatus for implanting a device
US9993329B2 (en) 2011-06-03 2018-06-12 Vascutek Limited Stent and stent graft prosthesis
US10137021B2 (en) 2011-06-03 2018-11-27 Vascutek Limited Method and apparatus for controlling the deployment of a stent
CN114948334A (zh) * 2022-04-11 2022-08-30 上海玮琅医疗科技有限公司 一种肺动脉覆膜支架

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US6350279B1 (en) 1998-01-26 2002-02-26 Ave Connaught Endoluminal stents and their manufacture
WO1999037245A1 (fr) * 1998-01-26 1999-07-29 Arterial Vascular Engineering, Inc. Extenseurs endoluminaux et leur fabrication
US7402169B2 (en) 1998-03-04 2008-07-22 Boston Scientific Scimed, Inc. Stent having variable properties and method of its use
US7060091B2 (en) 1998-03-04 2006-06-13 Boston Scientific Scimed, Inc. Stent having variable properties and method of its use
EP1598031A3 (fr) * 1998-03-04 2005-11-30 Boston Scientific Limited Extenseur ayant des propriétés variables
EP1598031A2 (fr) 1998-03-04 2005-11-23 Boston Scientific Limited Extenseur ayant des propriétés variables
US7780719B2 (en) 1998-03-04 2010-08-24 Boston Scientific Scimed, Inc. Stent having variable properties and method of its use
EP0970711A2 (fr) * 1998-06-30 2000-01-12 Ethicon, Inc. Procédé de revêtement d'extenseurs vasculaires
EP0970711A3 (fr) * 1998-06-30 2001-01-10 Ethicon, Inc. Procédé de revêtement d'extenseurs vasculaires
EP0997116B1 (fr) * 1998-10-26 2003-06-11 Medinol Ltd. Stent recouvert, déployable par gonflement d'un ballon
FR2785174A1 (fr) * 1998-11-03 2000-05-05 Jacques Seguin Extenseur de conduit corporel, notamment vasculaire
WO2000025702A1 (fr) * 1998-11-03 2000-05-11 Jacques Seguin Extenseur de conduit corporel, notamment vasculaire
EP1005843A3 (fr) * 1998-12-03 2000-09-20 Medinol Ltd. Ensemble de stents à détachement controlé
AU757936B2 (en) * 1998-12-03 2003-03-13 Medinol Ltd Controlled detachment stents
AU757936C (en) * 1998-12-03 2004-02-05 Medinol Ltd Controlled detachment stents
US6355057B1 (en) 1999-01-14 2002-03-12 Medtronic, Inc. Staggered endoluminal stent
EP1029517A3 (fr) * 1999-01-14 2001-08-01 Medtronic Inc. Stent endoluminal à structure décalée
US6258117B1 (en) 1999-04-15 2001-07-10 Mayo Foundation For Medical Education And Research Multi-section stent
WO2000062708A1 (fr) * 1999-04-15 2000-10-26 Mayo Foundation For Medical Education And Research Extenseur multisection
AU772971B2 (en) * 1999-04-15 2004-05-13 Mayo Foundation For Medical Education And Research Multi-section stent
EP1723932A2 (fr) * 1999-04-15 2006-11-22 Mayo Foundation For Medical Education And Research Stent multi-section
US6699280B2 (en) 1999-04-15 2004-03-02 Mayo Foundation For Medical Education And Research Multi-section stent
US6485510B1 (en) 1999-04-15 2002-11-26 Mayo Foundation For Medical Education And Research Multi-section stent
EP1723932A3 (fr) * 1999-04-15 2010-09-29 Mayo Foundation For Medical Education And Research Stent multi-section
WO2001021101A1 (fr) * 1999-09-22 2001-03-29 Andrei Vladimirovich Karev Extenseur souple expansible et procede de fabrication correspondant
US6913762B2 (en) 2001-04-25 2005-07-05 Mayo Foundation For Medical Education And Research Stent having non-woven framework containing cells
US6796999B2 (en) 2001-09-06 2004-09-28 Medinol Ltd. Self articulating stent
US8308795B2 (en) 2001-11-05 2012-11-13 Biosensors International Group, Ltd. Drug-delivery endovascular stent and method of forming the same
JP2009011847A (ja) * 2002-04-24 2009-01-22 Biosensors Internatl Group Ltd 大環状トリエン化合物を含むポリマー組成物
JP2014087714A (ja) * 2002-04-24 2014-05-15 Biosensors Internatl Group Ltd 大環状トリエン化合物を含むポリマー組成物
US8715341B2 (en) 2002-04-24 2014-05-06 Biosensors International Group, Ltd. Drug-delivery endovascular stent and method of forming the same
JP2012091032A (ja) * 2002-04-24 2012-05-17 Biosensors Internatl Group Ltd 大環状トリエン化合物を含むポリマー組成物
US8252046B2 (en) 2002-04-24 2012-08-28 Biosensors International Group, Ltd. Drug-delivery endovascular stent and method for treating restenosis
JP2012205920A (ja) * 2002-04-24 2012-10-25 Biosensors Internatl Group Ltd 大環状トリエン化合物を含むポリマー組成物
JP2008279278A (ja) * 2002-04-24 2008-11-20 Biosensors Internatl Group Ltd 薬物送達脈管内ステントおよび再狭窄を処置するための方法
US8545550B2 (en) 2002-04-24 2013-10-01 Biosensors International Group, Ltd. Drug-delivery endovascular stent and method for treating restenosis
JP2013121509A (ja) * 2002-04-24 2013-06-20 Biosensors Internatl Group Ltd 薬物送達脈管内ステントおよび再狭窄を処置するための方法
US9456910B2 (en) 2003-06-27 2016-10-04 Medinol Ltd. Helical hybrid stent
US10363152B2 (en) 2003-06-27 2019-07-30 Medinol Ltd. Helical hybrid stent
US9039755B2 (en) 2003-06-27 2015-05-26 Medinol Ltd. Helical hybrid stent
WO2009091855A1 (fr) * 2008-01-17 2009-07-23 Boston Scientific Scimed, Inc. Système et procédé de déploiement d'un dispositif médical auto-extensible avec revêtement
WO2010092065A1 (fr) 2009-02-11 2010-08-19 INSERM (Institut National de la Santé et de la Recherche Médicale) Endoprothèse pour lésions cartilagineuses
US9155639B2 (en) 2009-04-22 2015-10-13 Medinol Ltd. Helical hybrid stent
US9622894B2 (en) 2011-06-03 2017-04-18 Vascutek Limited Apparatus for implanting a device
US9398964B2 (en) 2011-06-03 2016-07-26 Vascutek Limited Device for securing a prosthesis to the internal wall of a body lumen
US9510936B2 (en) 2011-06-03 2016-12-06 Vascutek Limited Stent element
WO2012164294A1 (fr) * 2011-06-03 2012-12-06 Vascutek Limited Élément d'endoprothèse
US9993329B2 (en) 2011-06-03 2018-06-12 Vascutek Limited Stent and stent graft prosthesis
US10137021B2 (en) 2011-06-03 2018-11-27 Vascutek Limited Method and apparatus for controlling the deployment of a stent
US11026823B2 (en) 2011-06-03 2021-06-08 Vascutek Limited Method and apparatus for controlling the deployment of a stent
WO2014158580A3 (fr) * 2013-03-14 2015-05-07 W.L. Gore & Associates, Inc. Méthodes et appareil d'assemblage d'endoprothèses-greffons
CN114948334A (zh) * 2022-04-11 2022-08-30 上海玮琅医疗科技有限公司 一种肺动脉覆膜支架

Also Published As

Publication number Publication date
EP1006938A1 (fr) 2000-06-14
CA2250954C (fr) 2006-11-21
AU729119B2 (en) 2001-01-25
AU2728097A (en) 1997-10-29
CA2250954A1 (fr) 1997-10-16
EP1006938A4 (fr) 2000-07-05

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