WO1995029647B1 - Stent with collagen - Google Patents
Stent with collagenInfo
- Publication number
- WO1995029647B1 WO1995029647B1 PCT/US1995/005147 US9505147W WO9529647B1 WO 1995029647 B1 WO1995029647 B1 WO 1995029647B1 US 9505147 W US9505147 W US 9505147W WO 9529647 B1 WO9529647 B1 WO 9529647B1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- combination
- stent
- collagen
- comprised
- type
- Prior art date
Links
- 102000008186 Collagen Human genes 0.000 title claims abstract 42
- 108010035532 Collagen Proteins 0.000 title claims abstract 42
- 229960005188 collagen Drugs 0.000 title claims abstract 42
- 229920001436 collagen Polymers 0.000 title claims abstract 42
- 230000002792 vascular Effects 0.000 claims abstract 9
- 238000002513 implantation Methods 0.000 claims abstract 2
- 239000000203 mixture Substances 0.000 claims 45
- 239000000463 material Substances 0.000 claims 22
- 239000003795 chemical substances by application Substances 0.000 claims 5
- 229920000346 polystyrene-polyisoprene block-polystyrene Polymers 0.000 claims 5
- 239000011248 coating agent Substances 0.000 claims 4
- 238000000576 coating method Methods 0.000 claims 4
- QTBSBXVTEAMEQO-UHFFFAOYSA-N acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims 3
- 239000002184 metal Substances 0.000 claims 3
- ZFGMDIBRIDKWMY-PASTXAENSA-N Heparin Chemical compound CC(O)=N[C@@H]1[C@@H](O)[C@H](O)[C@@H](COS(O)(=O)=O)O[C@@H]1O[C@@H]1[C@@H](C(O)=O)O[C@@H](O[C@H]2[C@@H]([C@@H](OS(O)(=O)=O)[C@@H](O[C@@H]3[C@@H](OC(O)[C@H](OS(O)(=O)=O)[C@H]3O)C(O)=O)O[C@@H]2O)CS(O)(=O)=O)[C@H](O)[C@H]1O ZFGMDIBRIDKWMY-PASTXAENSA-N 0.000 claims 2
- 229960002897 Heparin Drugs 0.000 claims 2
- 238000004070 electrodeposition Methods 0.000 claims 2
- 229920000669 heparin Polymers 0.000 claims 2
- 239000000243 solution Substances 0.000 claims 2
- 102000012422 Collagen Type I Human genes 0.000 claims 1
- 108010022452 Collagen Type I Proteins 0.000 claims 1
- 102000004266 Collagen Type IV Human genes 0.000 claims 1
- 108010042086 Collagen Type IV Proteins 0.000 claims 1
- 101710040692 PARPBP Proteins 0.000 claims 1
- 238000000151 deposition Methods 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 229940079593 drugs Drugs 0.000 claims 1
- 239000008151 electrolyte solution Substances 0.000 claims 1
- 239000004744 fabric Substances 0.000 claims 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 1
Abstract
Collagen applied to a vascular stent for increasing the biocompatibility of the stent on implantation and method of treatment.
Claims
AMENDED CLAIMS
[received by the International Bureau on 15 March 1996 (15.03.96); original claim 2 cancelled; original claims 1, 3-5, 14, 18, 20, 22, 25, 43-45, 47, 49 and 52 amended; remaining claims unchanged (4 pages)]
I . In combination, a vascular prostheses comprised of an expandable support framework, the expandable support framework comprising a stent, and a covering sleeve of a collagen material.
3. The combination of claim 1 in which the collagen material is in sheet form and is oriented with respect to the longitudinal dimension of the stent such that the stretch properties of the collagen are on a bias with respect thereto. 4. The combination of claim 1 wherein the collagen material covers the stent inside and out.
5. The combination of claim 4 wherein the collagen is in the form of an outer sleeve and an inner sleeve.
6. The combination of claim 1 wherein the collagen material is comprised of collagen per se.
7. The combination of claim 1 wherein the collagen material is comprised of collagen on a support.
8. The combination of claim 7 wherein the support is a fabric.
9. The combination of claim 1 wherein the framework is a stent of fixed diameter.
10. The combination of claim 1 wherein the framework is a stent of variable diameter.
II . The combination of claim 10 wherein the stent is of the self-expanding type. 12. The combination of claim 1 wherein the sleeve has elastic properties.
13. The combination of claim 1 wherein the sleeve is sized large with respect to the framework at least before implantation.
14. In combination, an implanted vascular expandable stent and a layer of collagen material positioned between the stent and the vascular wall. 15. The combination of claim 14 in which the collagen material is in the form of a sleeve overlying the stent.
16. The combination of claim 1 wherein the collagen includes added agent.
17. The combination of claim 16 wherein the agent is heparin.
18. In combination, an expandable stent coated with a collagen material.
19. In combination, a stent embedded in collagen material.
20. The method of treating the internal wall of a body vessel wherein collagen material is placed against the wall so as to be interposed between it and an expandable implanted prostheses.
21. The treatment method of claim 20 wherein the collagen includes an agent. 22. In combination, a vascular prostheses comprised of a generally cylindrical expandable support stent and an inner luminal liner.
23. The combination of claim 22 wherein the liner is comprised of collagen. 24. The combination of claim 23 in which the collagen material is in sheet form and is oriented with respect to the longitudinal dimension of the stent such that the stretch properties of the collagen are on a bias with respect thereto.
25. The combination of claim 22 wherein the collagen material comprises a bilayer arrangement. 26. The combination of claim 25 wherein one of the layers in the bilayer is a polymeric material.
27. The combination of claim 22 wherein the stent is of fixed diameter.
28. The combination of claim 22 wherein the stent is of variable diameter.
29. The combination of claim 28 wherein the stent is of the self -expanding type.
30. The combination of claim 22 wherein the liner has cuffs at either end which overlap the ends of the stent.
31. The combination of claim 22 wherein the collagen includes an added agent. 32. The combination of claim 31 wherein the agent is heparin.
33. The combination of claim 22 wherein the stent has wall openings and the liner is perforated.
34. The combination of claim 33 wherein the perforations are about 10-60 microns in diameter. 35. The combination of claim 26 wherein the bilayer liner is comprised at least two types of collagen material.
36. The combination of claim 35 wherein the collagen material includes Type I and Type IV layers.
37. The combination of claim 36 wherein the Type IV is SIS.
38. The combination of claim 37 wherein the Type IV is the innermost layer and the Type I layer includes a drug.
39. The combination of claim 1 including a multi-layer arrangement of Type I and Type IV collagen material on the outside of the stent.
40. The combination of claim 39 wherein the Type IV is the outermost layer.
41. The combination of claim 40 wherein the Type IV is SIS.
42. The combination of claim 22 including SIS collagen material on the outside of the stent. 43. In combination, a vascular prosthesis comprised of an expandable stent and inner and outer layer of SIS collagen material positioned on the stent.
44. In combination, a vascular prosthesis comprised of an expandable support framework coated with a collagen material and a collagen sleeve thereover.
45. In combination, a vascular prosthesis comprised of an expandable support framework and a collagen material overlaying at least a portion of a surface thereof.
46. The combination of claim 45 wherein the framework is comprised of a self-expanding stent.
47. In combination, a vascular prosthesis comprised of expandable stent, a collagen coating on the stent and a collagen sleeve on the outside of the stent. 48. The combination of claim 47 wherein the sleeve is SIS and the coating is Type I or Type IV.
49. An expandable stent comprised of an open framework including a collagen coating over the framework.
50. The stent of claim 49 wherein the framework is comprised of a network of interconnecting struts coated with collagen.
51. The stent of claim 49 wherein the framework is comprised of a wire network, the wire being coated with collagen.
52. An expandable stent comprised of a generally cylindrical body coated with a collagen material and carrying an overlying sleeve of collagen material. 53. The stent of claim 52 wherein the collagen coating is selected from the group consisting of Type IV and Type I.
54. The stent of claim 53 wherein the collagen sleeve is comprised of Type IV.
55. The method of depositing collagen coatings on a metal surface by electrodeposition.
56. The method of claim 55 wherein the metal surface functions as a cathode in an anode/cathode pari and is immersed in an aqueous electrolyte solution including collagen and an electrical potential is established between the anode and cathode adequate to sustain electrodeposition of the collagen from the solution onto the metal surface.
57. The method of claim 56 wherein the cathode is a stent.
58. The method of claim 56 wherein the potential is about 3 volts. 59. The method of claim 56 wherein the solution is comprised of acetic acid and water.
Priority Applications (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CA002188563A CA2188563C (en) | 1994-04-29 | 1995-04-26 | Stent with collagen |
| DE69527141T DE69527141T2 (en) | 1994-04-29 | 1995-04-26 | STENT WITH COLLAGEN |
| AT95917692T ATE219343T1 (en) | 1994-04-29 | 1995-04-26 | STENT WITH COLLAGEN |
| JP52835495A JP3766935B2 (en) | 1994-04-29 | 1995-04-26 | Stent with collagen |
| EP95917692A EP0754017B1 (en) | 1994-04-29 | 1995-04-26 | Stent with collagen |
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US23530094A | 1994-04-29 | 1994-04-29 | |
| US35022394A | 1994-12-06 | 1994-12-06 | |
| US08/350,223 | 1994-12-06 | ||
| US08/235,300 | 1994-12-06 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| WO1995029647A2 WO1995029647A2 (en) | 1995-11-09 |
| WO1995029647A3 WO1995029647A3 (en) | 1996-02-15 |
| WO1995029647B1 true WO1995029647B1 (en) | 1996-05-02 |
Family
ID=26928790
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/US1995/005147 WO1995029647A2 (en) | 1994-04-29 | 1995-04-26 | Stent with collagen |
Country Status (7)
| Country | Link |
|---|---|
| US (3) | US5693085A (en) |
| EP (2) | EP0754017B1 (en) |
| JP (2) | JP3766935B2 (en) |
| AT (2) | ATE219343T1 (en) |
| CA (2) | CA2188563C (en) |
| DE (2) | DE69527141T2 (en) |
| WO (1) | WO1995029647A2 (en) |
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| US9173733B1 (en) | 2006-08-21 | 2015-11-03 | Abbott Cardiovascular Systems Inc. | Tracheobronchial implantable medical device and methods of use |
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- 1995-04-26 DE DE69527141T patent/DE69527141T2/en not_active Expired - Lifetime
- 1995-04-26 CA CA002484826A patent/CA2484826C/en not_active Expired - Fee Related
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1997
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2006
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| US9295570B2 (en) | 2001-09-19 | 2016-03-29 | Abbott Laboratories Vascular Enterprises Limited | Cold-molding process for loading a stent onto a stent delivery system |
| US8846070B2 (en) | 2004-03-29 | 2014-09-30 | Advanced Cardiovascular Systems, Inc. | Biologically degradable compositions for medical applications |
| US9283099B2 (en) | 2004-08-25 | 2016-03-15 | Advanced Cardiovascular Systems, Inc. | Stent-catheter assembly with a releasable connection for stent retention |
| US9248034B2 (en) | 2005-08-23 | 2016-02-02 | Advanced Cardiovascular Systems, Inc. | Controlled disintegrating implantable medical devices |
| US9532888B2 (en) | 2006-01-04 | 2017-01-03 | Abbott Cardiovascular Systems Inc. | Stents with radiopaque markers |
| US9358325B2 (en) | 2006-05-26 | 2016-06-07 | Abbott Cardiovascular Systems Inc. | Stents with radiopaque markers |
| US8925177B2 (en) | 2006-06-19 | 2015-01-06 | Abbott Cardiovascular Systems Inc. | Methods for improving stent retention on a balloon catheter |
| US9259341B2 (en) | 2006-06-19 | 2016-02-16 | Abbott Cardiovascular Systems Inc. | Methods for improving stent retention on a balloon catheter |
| US9579225B2 (en) | 2006-06-19 | 2017-02-28 | Abbott Cardiovascular Systems Inc. | Methods for improving stent retention on a balloon catheter |
| US9173733B1 (en) | 2006-08-21 | 2015-11-03 | Abbott Cardiovascular Systems Inc. | Tracheobronchial implantable medical device and methods of use |
| US9101503B2 (en) | 2008-03-06 | 2015-08-11 | J.W. Medical Systems Ltd. | Apparatus having variable strut length and methods of use |
| US9198785B2 (en) | 2010-01-30 | 2015-12-01 | Abbott Cardiovascular Systems Inc. | Crush recoverable polymer scaffolds |
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