US8025896B2 - Porous extracellular matrix scaffold and method - Google Patents

Porous extracellular matrix scaffold and method Download PDF

Info

Publication number
US8025896B2
US8025896B2 US10/195,354 US19535402A US8025896B2 US 8025896 B2 US8025896 B2 US 8025896B2 US 19535402 A US19535402 A US 19535402A US 8025896 B2 US8025896 B2 US 8025896B2
Authority
US
United States
Prior art keywords
extracellular matrix
cohesive mass
submucosa
naturally occurring
sis
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active, expires
Application number
US10/195,354
Other versions
US20030044444A1 (en
Inventor
Prasanna Malaviya
Herbert E. Schwartz
Pamela L. Plouhar
Mark J. Pelo
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
DePuy Spine LLC
DePuy Synthes Products Inc
Original Assignee
DePuy Products Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by DePuy Products Inc filed Critical DePuy Products Inc
Priority to US10/195,354 priority Critical patent/US8025896B2/en
Assigned to DEPUY PRODUCTS, INC. reassignment DEPUY PRODUCTS, INC. ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: MALAVIYA, PRASANNA, SCHWARTZ, HERBERT E., PELO, MARK J., PLOUHAR, PAMELA L.
Publication of US20030044444A1 publication Critical patent/US20030044444A1/en
Application granted granted Critical
Publication of US8025896B2 publication Critical patent/US8025896B2/en
Assigned to DEPUY SPINE, LLC reassignment DEPUY SPINE, LLC ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: DEPUY PRODUCTS, INC.
Assigned to HAND INNOVATIONS LLC reassignment HAND INNOVATIONS LLC ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: DEPUY SPINE, LLC
Assigned to DePuy Synthes Products, LLC reassignment DePuy Synthes Products, LLC CHANGE OF NAME (SEE DOCUMENT FOR DETAILS). Assignors: HAND INNOVATIONS LLC
Active legal-status Critical Current
Adjusted expiration legal-status Critical

Links

Images

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3683Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment
    • A61L27/3691Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment characterised by physical conditions of the treatment, e.g. applying a compressive force to the composition, pressure cycles, ultrasonic/sonication or microwave treatment, lyophilisation
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02Prostheses implantable into the body
    • A61F2/30Joints
    • A61F2/30721Accessories
    • A61F2/30749Fixation appliances for connecting prostheses to the body
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3604Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the human or animal origin of the biological material, e.g. hair, fascia, fish scales, silk, shellac, pericardium, pleura, renal tissue, amniotic membrane, parenchymal tissue, fetal tissue, muscle tissue, fat tissue, enamel
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3604Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the human or animal origin of the biological material, e.g. hair, fascia, fish scales, silk, shellac, pericardium, pleura, renal tissue, amniotic membrane, parenchymal tissue, fetal tissue, muscle tissue, fat tissue, enamel
    • A61L27/3633Extracellular matrix [ECM]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3641Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the site of application in the body
    • A61L27/3645Connective tissue
    • A61L27/365Bones
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3641Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the site of application in the body
    • A61L27/3645Connective tissue
    • A61L27/3654Cartilage, e.g. meniscus
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3683Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3839Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by the site of application in the body
    • A61L27/3843Connective tissue
    • A61L27/3847Bones
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3839Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by the site of application in the body
    • A61L27/3843Connective tissue
    • A61L27/3852Cartilage, e.g. meniscus
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/56Porous materials, e.g. foams or sponges
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/005Ingredients of undetermined constitution or reaction products thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/064Surgical staples, i.e. penetrating the tissue
    • A61B2017/0646Surgical staples, i.e. penetrating the tissue for insertion into cartillege, e.g. meniscus
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/0063Implantable repair or support meshes, e.g. hernia meshes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02Prostheses implantable into the body
    • A61F2/08Muscles; Tendons; Ligaments
    • A61F2/0811Fixation devices for tendons or ligaments
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02Prostheses implantable into the body
    • A61F2/30Joints
    • A61F2/38Joints for elbows or knees
    • A61F2/3872Meniscus for implantation between the natural bone surfaces
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02Prostheses implantable into the body
    • A61F2/30Joints
    • A61F2002/30001Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
    • A61F2002/30108Shapes
    • A61F2002/30199Three-dimensional shapes
    • A61F2002/30291Three-dimensional shapes spirally-coiled, i.e. having a 2D spiral cross-section
    • A61F2002/30294Conical or frustoconical body made by spirally rolling up a sheet or a strip around itself
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02Prostheses implantable into the body
    • A61F2/30Joints
    • A61F2/30721Accessories
    • A61F2/30749Fixation appliances for connecting prostheses to the body
    • A61F2002/30751Fixation appliances for connecting prostheses to the body for attaching cartilage scaffolds to underlying bone
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02Prostheses implantable into the body
    • A61F2/30Joints
    • A61F2/30756Cartilage endoprostheses
    • A61F2002/30766Scaffolds for cartilage ingrowth and regeneration
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2230/00Geometry of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2230/0063Three-dimensional shapes
    • A61F2230/0091Three-dimensional shapes helically-coiled or spirally-coiled, i.e. having a 2-D spiral cross-section
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00Materials or treatment for tissue regeneration
    • A61L2430/06Materials or treatment for tissue regeneration for cartilage reconstruction, e.g. meniscus

Definitions

  • the present disclosure relates generally to an extracellular matrix scaffold, and more particularly to a porous extracellular matrix scaffold for repairing or regenerating body tissue and a method for making such a scaffold.
  • SIS small intestine submucosa
  • SIS small intestine submucosa
  • SIS has been used to repair, support, and stabilize a wide variety of anatomical defects and traumatic injuries.
  • Commercially-available SIS material is derived from porcine small intestinal submucosa that remodels to the qualities of its host when implanted in human soft tissues.
  • the SIS material provides a natural matrix with a three-dimensional microstructure and biochemical composition that facilitates host cell proliferation and supports tissue remodeling.
  • SIS has been shown to contain biological molecules, such as growth factors and glycosaminoglycans that aid in the repair of soft tissue of the human body.
  • the SIS material currently being used in the orthopaedic field is provided in a dried and layered configuration in the form of a patch to repair or regenerate soft tissue such as tendons, ligaments and rotator cuffs.
  • ECM ECM
  • stomach, bladder, alimentary, respiratory, or genital submucosa or liver basement membrane.
  • liver basement membrane See, e.g., U.S. Pat. Nos. 6,379,710, 6,171,344; 6,099,567; and 5,554,389, each of which is hereby incorporated by reference.
  • SIS is most often porcine derived
  • various submucosa materials may also be derived from non-porcine sources, including bovine and ovine sources.
  • the ECM material may also include partial layers of laminar muscularis mucosa, muscularis mucosa, lamina basement, stratum compactum and/or other such tissue materials depending upon factors such as the source from which the ECM material was derived and the delamination procedure.
  • a naturally occurring extracellular matrix to clean, delaminate, and/or comminute the extracellular matrix, or to cross-link the collagen or other components within the extracellular matrix. It is also within the definition of naturally occurring extracellular matrix to fully or partially remove one or more components or subcomponents of the naturally occurring matrix. However, it is not within the definition of a naturally occurring extracellular matrix to separate and purify the natural components or subcomponents and reform a matrix material from purified natural components or subcomponents.
  • SIS it is understood that other naturally occurring extracellular matrices (e.g. stomach, bladder, alimentary, respiratory, and genital submucosa, and liver basement membrane), whatever the source (e.g.
  • bovine, porcine, ovine are within the scope of this disclosure.
  • the terms “naturally occurring extracellular matrix” or “naturally occurring ECM” are intended to refer to extracellular matrix material that has been cleaned, processed, sterilized, and optionally crosslinked.
  • scaffold pore size, porosity, and interconnectivity is an important science contributing to the field of tissue engineering (Ma and Zhang, 2001, J Biomed Mater Res, 56(4):469-477; Ma and Choi, 2001 Tissue Eng, 7(1):23-33) because it is believed that the consideration of scaffold pore size and density/porosity influences the behavior of cells and the quality of tissue regenerated.
  • tissue engineering Ma and Zhang, 2001, J Biomed Mater Res, 56(4):469-477; Ma and Choi, 2001 Tissue Eng, 7(1):23-33
  • pore sizes influence the behavior of cells in porous three-dimensional matrices. For example, it has been demonstrated in the art that for adequate bone regeneration to occur scaffold pore size needs to be at least 100 microns (Klawitter et al., 1976, J Biomed Mater Res, 10(2):311-323).
  • cartilage cells exhibit appropriate protein expression (type II collagen) in scaffolds with pore sizes of the order of 20 microns and tend to dedifferentiate to produce type I collagen in scaffolds with nominal porosity of about 80 microns (Nehrer et al., 1997, Biomaterials, 18(11):769-776).
  • a method of making an implantable scaffold for repairing damaged or diseased tissue includes the step of suspending, mixing, or otherwise placing pieces of a naturally occurring extracellular matrix material in a liquid.
  • the naturally occurring extracellular matrix material and the liquid are formed into a mass.
  • the liquid is subsequently driven off so as to form interstices in the mass.
  • the liquid is driven off by freeze drying the naturally occurring extracellular matrix material and the liquid in which it is suspended. In such a manner, the liquid is sublimed thereby forming the interstices in the mass.
  • the material density and pore size of the scaffold may be varied by controlling the rate of freezing of the suspension.
  • the amount of water into which the pieces of naturally occurring extracellular matrix material is suspended may also be varied to control the material density and pore size of the resultant scaffold.
  • an implantable scaffold for repairing or regenerating tissue which is prepared by the process described above.
  • the present disclosure provides an implantable scaffold for repairing or regenerating body tissue.
  • the scaffold comprises a porous body of naturally occurring extracellular matrix pieces that are interconnected to define an interior surface of the body.
  • the interior surface has a three-dimensional topography of irregular shape.
  • the present disclosure provides an implantable device for repairing or regenerating body tissue.
  • the device comprises a three-dimensional reticulated foam comprising a plurality of interconnected pores.
  • the interconnected pores define three-dimensional interconnected passageways having irregular shapes. At least part of the reticulated foam comprises naturally occurring extracellular matrix.
  • the present disclosure provides a method of making an implantable device for repairing or regenerating body tissue.
  • the method comprises the steps of providing a naturally occurring extracellular matrix material in a raw form, comminuting the raw naturally occurring extracellular matrix in the presence of a liquid to form a slurry of naturally occurring extracellular matrix, and lyophilizing the slurry of naturally occurring extracellular matrix to form a reticulated foam of naturally occurring extracellular matrix.
  • the present disclosure provides a method of making an implantable scaffold for repairing or regenerating body tissue.
  • the method comprises the steps of providing a naturally occurring extracellular matrix material in a raw form, comminuting the raw naturally occurring extracellular matrix to form cohesive pieces of naturally occurring extracellular matrix, and lyophilizing the cohesive pieces of naturally occurring extracellular matrix to form a reticulated foam of naturally occurring extracellular matrix.
  • the implantable devices disclosed herein are three dimensional, porous scaffolds of ECMs like SIS. As such, it is evident that an implant based on the teachings of the present disclosure will have the dual advantage of having not only the appropriate biochemistry (collagens, growth factors, glycosaminoglycans, etc. naturally found in such ECMs) but also the appropriate physical microstructure to enable desired cellular activity upon implantation. These implantable devices are likely to find therapeutic use in the orthopaedic field, for devices used in the treatment of diseased or damaged fibro-cartilage such as the meniscus, diseased or damaged articular cartilage, and diseased or damaged bone.
  • diseased or damaged fibro-cartilage such as the meniscus, diseased or damaged articular cartilage, and diseased or damaged bone.
  • FIG. 1 is an image from a scanning electron microscope which shows the surface of a porous reticulated SIS open cell foam scaffold having a relatively large pore size and a relatively low material density;
  • FIG. 2 is an image from a scanning electron microscope which shows the surface of a porous reticulated SIS open cell foam scaffold having a relatively moderate pore size and a relatively moderate material density;
  • FIG. 3 is an image from a scanning electron microscope which shows the surface of a porous reticulated SIS open cell foam scaffold having a relatively small pore size and a relatively high material density;
  • FIG. 4 is an image from a scanning electron microscope which shows a cross-section of a porous reticulated SIS open cell foam scaffold, with an example of a pore indicated by the arrow, the image being at a greater magnification than the images of FIGS. 1-3 ;
  • FIG. 5 is an image from a scanning electron microscope which shows a cross-section of a porous reticulated SIS open cell foam scaffold, with examples of pores indicated by the arrows, the image being at a greater magnification than the images of FIGS. 1-3 ;
  • FIG. 6 is an image from a scanning electron microscope which shows a cross-section of a porous reticulated SIS open cell foam scaffold, with examples of pores indicated by the arrows, the image being at a greater magnification than the images of FIGS. 1-3 ;
  • FIG. 7 is an image from a scanning electron microscope which shows a cross-section of a porous reticulated SIS open cell foam scaffold, the image being at a greater magnification than the images of FIGS. 1-3 ;
  • FIG. 8 is an image from a scanning electron microscope which shows a surface of a porous reticulated SIS open cell foam scaffold, the image being at a greater magnification than the images of FIGS. 1-3 ;
  • FIGS. 9 and 10 are images from a scanning electron microscope which show a mass of cohesive SIS pieces.
  • the present disclosure relates to a porous scaffold for implanting into the body of a patient to repair or regenerate damaged or diseased tissue.
  • the porous scaffold is constructed from a naturally occurring extracellular material.
  • the scaffold may be constructed from SIS.
  • both the material density and the pore size of the porous scaffold may be varied to fit the needs of a given scaffold design.
  • porous scaffolds may be fabricated by suspending pieces of an extracellular matrix material in a liquid.
  • piece is intended to mean any fiber, strip, ribbon, sliver, filament, shred, bit, fragment, part, flake, slice, cut, chunk, or other portion of solid or solid-like material.
  • the term “suspending” is intended to include any placement of a solid (e.g., pieces of ECM) in a liquid whether or not an actual suspension is created.
  • the term “suspending” is intended to include any mixing of a solid in a liquid or any other placement of a solid in a liquid.
  • the term “suspension” is likewise not intended to be limited to suspensions, but rather is intended to mean any mass having a solid present in a liquid.
  • the suspension of the pieces of extracellular matrix material and the liquid forms a mass in the form of, for example, a “slurry”.
  • the liquid may then be subsequently driven off of the mass so as to form interstices therein.
  • the liquid may be driven off in a number of different manners.
  • the liquid may be driven off via sublimation in a freeze drying process.
  • the liquid may also be driven off by subjecting the suspension to either an unheated vacuum process or a vacuum under a controlled heating process.
  • the liquid may also be driven off from the suspension ultrasonically. Microwave energy, RF energy, UV energy, or any other type of energy (or combination thereof) may also be utilized to drive the liquid off of the suspension.
  • Liquid may also be driven off of the suspension by forcing or drawing air through the suspension.
  • the suspension may be centrifuged to drive off the liquid.
  • the liquid may include a water-soluble filler which is driven off, for example, by use of an alcohol.
  • the present disclosure contemplates the driving off of the liquid from the suspension by any liquid removal process.
  • any of the aforementioned processes for driving off the liquid from the suspension may be utilized, along with any other process known by one skilled in the art, the processes of the present disclosure will herein be exemplary described in regard to a lyophilization process (i.e., freeze drying). However, it should be understood that such a description is merely exemplary in nature and that any one or more of the aforedescribed processes for driving off the liquid from the suspension may be utilized to fit the needs of a given scaffold design or process design.
  • one useful process for fabricating the porous scaffolds of the present disclosure is by lyophilization.
  • pieces of an extracellular matrix material are suspended in a liquid.
  • the suspension is then frozen and subsequently lyophilized. Freezing the suspension causes the liquid to be turned to ice crystals. These ice crystals are then sublimed under vacuum during the lyophilization process thereby leaving interstices in the material in the spaces previously occupied by the ice crystals.
  • the material density and pore size of the resultant scaffold may be varied by controlling, amongst other things, the rate of freezing of the suspension and/or the amount of water in which the extracellular matrix material is suspended in at the on-set of the freezing process.
  • the first step in fabricating a porous scaffold with a desired pore size and density is the procurement of comminuted SIS.
  • scissor-cut SIS runners ( ⁇ 6′′ long) are positioned in a 1700 series ComitrolTM machine, commercially available from Urschel Laboratories (Valparaiso, Ind.).
  • the SIS material is processed in the presence of a liquid and thereafter collected in a receptacle at the output of the machine.
  • the material is then processed through the machine a second time under similar conditions.
  • a liquid e.g., water
  • a liquid e.g., water
  • the resultant material is a “slurry” of SIS material (thin, long SIS fibers ⁇ 200 microns thick ⁇ 1-5 mm long) suspended in a substantially uniform manner in water.
  • SIS material thin, long SIS fibers ⁇ 200 microns thick ⁇ 1-5 mm long
  • the suspension is herein described as being formed as a byproduct of the comminuting process, it should be appreciated that the pieces of SIS may be suspended in the liquid (i.e., water) in other manners known to those skilled in the art.
  • comminuted SIS comprises, ribbon-like or string-like fibers wherein at least some of the individual pieces of ECM and SIS material have lengths greater than their widths and thicknesses. Such fibers may be interlaced to provide a felt-like material, if desired.
  • Process parameters can be varied using the above-identified 1700 series ComitrolTM machine, including the choice of blade used, whether water is used, the amount of water used, the speed at which the blades turn, and the number of times the material is passed through the machine.
  • cutting head 140084-10 and a Vericut, sealed impeller from Urschel Laboratories may be used, with a flow of water of about two (2) gallons per minute, with the blade running at a constant speed of about 9300 rpm.
  • a first pass through the machine at these parameters will produce fibrous SIS material of varying sizes, and a second pass will produce SIS fibers of a more uniform size.
  • the comminuted material may be tested to determine if it has the consistency of that which is desired for use in regard to the illustrative embodiments described herein by the following process: the comminuted SIS suspension or slurry is centrifuged, excess water is poured off and the remaining slurry is poured into a dish.
  • a small amount of the comminuted SIS material in the dish is pinched between the thumb and index finger and gently lifted from the dish.
  • at least a small amount of additional SIS, beyond the portion pinched between the thumb and index finger will lift along with the material that has been pinched (“pinch test”).
  • This additional comminuted SIS material lifts with the material that is between the thumb and index finger because the individual pieces of comminuted SIS material are commingled or intertwined.
  • cohesive ECM cohesive ECM
  • cohesive SIS cohesive ECM pieces
  • cohesive SIS pieces are used herein to respectively denote ECM or SIS material that has been comminuted or otherwise physically processed to produce ECM or SIS pieces that are capable of comingling or intertwining (in the wet or dry state) to form a mass of discrete pieces of ECM or SIS that remain massed together under some conditions (such as under gravity), regardless of the shape or shapes of the individual ECM or SIS pieces.
  • One method of demonstrating that the ECM or SIS material comprises cohesive pieces is the “pinch test” described in the preceding paragraph.
  • the base material comprised cohesive ECM or SIS pieces.
  • the ECM or SIS pieces are sufficiently cohesive to each other (or to other pieces in the mix or slurry) that they remain unified throughout the process used to produce the foam structure. Examples of cohesive SIS pieces are shown in the scanning electron microscopic images of FIGS. 9 and 10 .
  • the comminuted SIS suspension is frozen and lyophilized (i.e., freeze dried).
  • the SIS suspension is frozen at a controlled rate of temperature drop to control the size of the formed ice crystals.
  • the lyophilization process sublimes the ice crystals directly to a vapor under vacuum and low temperatures. This leaves voids or interstices in the spaces previously occupied by the ice crystals.
  • any commercially available freezer for freezing the suspension to a desired temperature may be used.
  • any commercially available lyophilizer may be used for the lyophilization process.
  • One exemplary machine for performing the lyophilization process is a Virtis GenesisTM Series lyophilizer which is commercially available from SP Industries, Inc. of Gardiner, N.Y.
  • the process parameters of the aforedescribed fabrication process may be varied to produce scaffolds of varying pore sizes and material densities.
  • the rate at which the suspension is frozen, the amount of water present in the suspension, or the compactness of the extracellular matrix material may be varied to produce scaffolds of varying pore sizes and material densities.
  • the extracellular matrix suspension may be frozen at a slow, controlled rate (e.g., ⁇ 1° C./min or less) to a temperature of about ⁇ 20° C., followed by lyophilization of the resultant mass.
  • a slow, controlled rate e.g., ⁇ 1° C./min or less
  • the extracellular matrix material may be tightly compacted by centrifuging the material to remove a portion of the liquid (e.g., water) in a substantially uniform manner prior to freezing. Thereafter, the resultant mass of extracellular matrix material is flash-frozen using liquid nitrogen followed by lyophilization of the mass.
  • the extracellular matrix material is first tightly compacted by centrifuging the material to remove a portion of the liquid (e.g., water) in a substantially uniform manner prior to freezing. Thereafter, the resultant mass of extracellular matrix material is frozen at a relatively fast rate (e.g., > ⁇ 1° C./min) to a temperature of about ⁇ 80° C. followed by lyophilization of the mass.
  • a relatively fast rate e.g., > ⁇ 1° C./min
  • Example 1 demonstrates the fabrication of a porous SIS scaffold having a relatively large pore size and a relatively low material density.
  • Such scaffolds are obtained by freezing a comminuted SIS suspension at a slow, controlled rate ( ⁇ 1° C./min or less) to ⁇ 20° C., followed by lyophilization.
  • the procedure is as follows. First, comminuted SIS is fabricated as described above. Specifically, scissor-cut SIS runners ( ⁇ 6′′ long) are placed in a suitable comminuting machine such as the Urschel Comitrol machine described above. The comminuted SIS is collected in a receptacle at the output of the machine. The collected material is then processed through the machine a second time, under the same conditions as before. The resultant mass is a “slurry” of SIS material (thin, long SIS fibers ⁇ 200 microns thick ⁇ 1-5 mm long) suspended relatively uniformly in water.
  • a slow-freeze ethanol bath is prepared as follows. Pour enough ethanol to obtain about a 1 centimeter head in a flat-bottomed plastic container large enough to hold four 24-well culture plates. Place the container in a ⁇ 20° C. freezer. The mass of each of four empty twenty-four well plates is then recorded. Under a sterile hood using sterile conditions, an approximately 3 ml aliquot of the comminuted SIS material is placed in each well of the tissue culture plates. The mass of each full plate of material is then recorded. The four culture plates are then placed into the ethanol freeze bath and allowed to freeze overnight.
  • the frozen plates are then removed from the ethanol bath and placed in a suitable lyophilization machine such as the Virtis Genesis Series lyophilizer described above. Without allowing the frozen SIS material to thaw, the process of lyophilization sublimes ice crystals directly to vapor under vacuum and low temperatures. This leaves voids or interstices in the spaces previously occupied by the ice crystals.
  • the parameters used in the lyophilization process include a first period at a primary drying temperature of ⁇ 13° C. for 8 hours, followed by a second period at a secondary drying temperature of 35° C. for 4 hours.
  • a scanning electron image of the surface of the samples was taken to visualize the relative pore sizes. These pore sizes are about 600 microns to about 700 microns.
  • An image indicative of the samples prepared in accordance with Example 1 is shown in FIG. 1 .
  • Pore sizes can be determined from scanning electron microscope images of the exterior surface of the foam, as in FIGS. 1-3 and 8 , and of cross-sections of the foam, as in FIGS. 4-7 . These images may be used in conjunction with standard commercially available image analysis software to determine the ranges of pore sizes.
  • FIGS. 4-6 illustrate the results of using suitable commercially-available software to measure or estimate the pore sizes in the foam. This technique was used to determine that the Example 1 foam had pores in the range of 600-700 microns. The sample may also include smaller pores.
  • Example 2 demonstrates the fabrication of a porous SIS scaffold having a relatively moderate pore size and a relatively moderate material density.
  • Such scaffolds are obtained by compacting the comminuted SIS material by centrifugation, freezing at a faster rate (relative to Example 1) and to a lower temperature (i.e., to ⁇ 80° C.), followed by lyophilization of the resultant mass.
  • the procedure is as follows. First, comminuted SIS is fabricated as described above in regard to Example 1.
  • scissor-cut SIS runners ( ⁇ 6′′ long) is comminuted by two passes through a suitable comminuting machine to produce a “slurry” of SIS material (thin, long SIS fibers ⁇ 200 microns thick ⁇ 1-5 mm long) suspended relatively uniformly in water.
  • the plates are then balanced for centrifuging by use of the following technique.
  • the two plates are placed on the balance, and RO water is added to the area in between the wells of the lighter plate until the two plates are balanced.
  • the two plates are then placed across from one another in the centrifuge, and centrifuged at 3000 rpm for seven minutes. Once done, the plates are removed from the centrifuge, and the water is emptied therefrom. The mass of each of the plates is then recorded. The centrifuging and mass measurement process is then repeated for the remaining plates.
  • the plates are then placed in a ⁇ 80° C. freezer until the specimen is fully frozen. Depending upon the bulk of the material, the time for full freezing can vary from about 1 to about 30 minutes, for example.
  • the frozen plates are then removed from the freezer and placed in a suitable lyophilization machine and lyophilized under similar parameters to as described above in regard to Example 1 (i.e., for a first period at a primary drying temperature of ⁇ 13° C. for 8 hours, followed by a second period at a secondary drying temperature of 35° C. for 4 hours).
  • Example 2 As with the samples of Example 1, a scanning electron image of the surface of each of the samples prepared in accordance with Example 2 was taken to visualize the relative pore sizes. An image indicative of the samples prepared in accordance with Example 2 is shown in FIG. 2 . Using the technique described above for determining pore size, this sample was found to have pores in the range of about 100-150 microns.
  • Example 3 demonstrates the fabrication of a porous SIS scaffold having a relatively small pore size and a relatively high material density. Such scaffolds are obtained by compacting the comminuted SIS material to an even higher density than in Example 2, flash-freezing the samples using liquid nitrogen, followed by lyophilization.
  • the procedure is as follows. First, comminuted SIS is fabricated as described above in regard to Examples 1 and 2. Specifically, scissor-cut SIS runners ( ⁇ 6′′ long) is comminuted by two passes through a suitable comminuting machine to produce a “slurry” of SIS material (thin, long SIS fibers ⁇ 200 microns thick ⁇ 1-5 mm long) suspended relatively uniformly in water.
  • the dead weights are prepared as follows. Forty-eight strips of 3 MTM COBANTM Self-Adherent Wrap (commercially available from 3 MTM of St. Paul, MN) are cut into pieces that measure 50 mm in length and 5mm in width (unstretched).
  • COBANTM Self-Adherent Wrap is a laminate of nonwoven material and elastic fibers placed lengthwise to provide elasticity. The elastic wrap contains a cohesive material that makes it stick to itself but not to other materials or skin. Thereafter, the pieces are stretched and wrapped around the outer edges of a polyethylene disk measuring 1 cm in diameter and 2 mm in thickness. Each strip is trimmed, if need be, so that the COBANTM Self-Adherent Wrap strips wrap around the disk two times.
  • the wells of the plates are combined at a ratio of 2:1 thereby reducing the number of plates from four to two.
  • An attempt is made to combine low material wells with high material wells in order to have a somewhat consistent amount of SIS material in each well.
  • the mass of each full plate is then recorded.
  • the polyethylene disks wrapped with COBANTM Self-Adherent Wrap are then placed into each well.
  • the two plates are then balanced using the technique described above in regard to Example 2.
  • the plates are then centrifuged at 3000 rpm for five minutes. Thereafter, the plates are removed from the centrifuge, the water is emptied therefrom, and the polyethylene disks are also removed. The mass of each plate is again recorded.
  • the two plates are balanced once again (in a manner similar to as described above in regard to Example 2), and the plates are again centrifuged at 3000 rpm for seven minutes. Once done, the water is emptied again from each of the plates, and the mass of each plate is again recorded.
  • a liquid nitrogen bath is prepared by pouring liquid nitrogen into a wide-mouthed liquid nitrogen container.
  • the plates are kept in the centrifuge until the bath is ready. Thereafter, each plate is dipped into the bath and held in the liquid for approximately 15 seconds.
  • the plates Upon removal from the nitrogen bath, the plates are immediately placed in a ⁇ 80° C. freezer to prevent thawing.
  • the frozen plates are then removed from the freezer and placed in a suitable lyophilization machine and lyophilized under similar parameters to as described above in regard to Examples 1 and 2 (i.e., for a first period at a primary drying temperature of ⁇ 13° C. for 8 hours, followed by a second period at a secondary drying temperature of 35° C. for 4 hours).
  • each of the illustrated ECM foams comprises a three-dimensional network of reticulated naturally occurring ECM defining a plurality of interconnected pores.
  • the foam has these pores throughout its height, width, and thickness.
  • the pores are open and interconnected to define a plurality of irregularly-shaped interconnected passageways leading from the exterior surface of the foam (see FIGS. 1-3 and 8 ) into the interior of the foam (see cross-sections FIGS. 4-7 ).
  • These interconnected passageways are three-dimensional.
  • the sizes of the pores, and therefore the maximum size for the interconnected passageways can be controlled by controlling the manufacturing process as described above.
  • interconnected passageways facilitate cell migration through the implant and enable efficient nutrient exchange in vivo.
  • These interconnected passageways also provide a means of transmitting bioactive agents, biologically derived substances (e.g. stimulants), cells and/or biological lubricants, biocompatible inorganic materials, synthetic polymers and biopolymers (e.g. collagen) throughout the length, width and thickness of the ECM prior to implantation.
  • the interconnected passageways defined by the pores also serve as passageways for materials used during the manufacturing process, such as compounds used for chemically cross-linking the foam.
  • These interconnected passageways as well as the outer surfaces of the foam may also serve as sites on which the above materials are carried.
  • the process parameters can be varied to produce an ECM foam that has the desired porosity for the particular application. For example, it may be desirable to produce a foam with lower density (and higher porosity) for applications involving osteocytes and to produce a foam with higher density (and lower porosity) for applications involving chondrocytes.
  • the ECM foams described herein may be crosslinked. Specifically, the ECM foams described herein may be either chemically or physically crosslinked.
  • each of the illustrated ECM foams comprises interconnected pieces of naturally occurring extracellular matrix.
  • these interconnected pieces of naturally occurring extracellular matrix provide the foam with an interior surface having an three-dimensional topography of irregular shape.
  • these interconnected pieces of naturally occurring extracellular matrix provide the foam with exterior surfaces having three-dimensional topographies of irregular shapes. With these irregular three-dimensional topographies and the interconnected passageways, the ECM foams of the present disclosure provide a relatively large surface area of naturally occurring ECM.
  • Such a large surface area of naturally occurring ECM can be advantageous in providing a relatively large surface area to which biological agents, biologically derived agents, cells, biocompatible polymers and biocompatible inorganic materials can be affixed pre-implantation.
  • the illustrated ECM foams provide a relatively large surface of area of naturally occurring ECM to which cells may attach in vivo.
  • ECM foam products can be made with substantially lower densities than those of other ECM products.
  • density of the commercially available RESTORE® product (DePuy Orthopaedics. Inc. in Warsaw. Ind), an ECM laminate, is 0.466+/ ⁇ 0.074 g/cc.
  • the DePuy product is described for use during rotator cuff surgery. and is provided as a resorbable framework that allows the rotator cuff tendon to regenerate itself.
  • the RESTORE® Implant is derived from porcine small intestine submucosa that has been cleaned. disinfected, and sterilized.
  • An ECM product consisting of comminuted and hardened SIS as described in U.S.
  • the ECM foams of the present disclosure may be combined with bioactive agents, biologically derived substances, cells and/or stimulants, biocompatible inorganic materials and/or biocompatible polymers (e.g. biocompatible synthetic polymers and biopolymers) and combinations of two or more of these materials at the time of manufacture.
  • cells can be seeded throughout the three-dimensional volume of the ECM foam; the biological materials can be dried on the ECM foam at manufacture; the biological materials and the ECM foam can be co-lyophilized; and the biological materials can be covalently linked to the ECM foam. It is contemplated to bond, cross-link, or otherwise incorporate one or more of these materials to the raw ECM material prior to formation of the ECM foam.
  • the materials could be bonded, cross-linked, or otherwise incorporated to the final ECM foam after lyophilization.
  • combinations of the above methods may be used.
  • an implant of covalently linked ECM foam and biological lubricant can be implanted and additional intra-articular injections of the same or different biological lubricants can be made at surgery, post-operatively, or both at surgery and post-operatively.
  • Bioactive agents include one or more of the following: chemotactic agents; therapeutic agents (e.g. antibiotics, steroidal and non-steroidal analgesics and anti-inflammatories, anti-rejection agents such as immunosuppressants and anti-cancer drugs); various proteins (e.g. short chain peptides, bone morphogenic proteins, glycoprotein and lipoprotein); cell attachment mediators; biologically active ligands; integrin binding sequence; ligands; various growth and/or differentiation agents (e.g.
  • epidermal growth factor IGF-I, IGF-II, TGF- ⁇ I-III, growth and differentiation factors, vascular endothelial growth factors, fibroblast growth factors, platelet derived growth factors, insulin derived growth factor and transforming growth factors, parathyroid hormone, parathyroid hormone related peptide, bFGF; TGF ⁇ superfamily factors; BMP-2; BMP-4; BMP-6; BMP-12; sonic hedgehog; GDF5; GDF6; GDF8; PDGF); small molecules that affect the upregulation of specific growth factors; tenascin-C; hyaluronic acid; chondroitin sulfate; fibronectin; decorin; thromboelastin; thrombin-derived peptides; heparin-binding domains; heparin; heparan sulfate; DNA fragments and DNA plasmids.
  • Bioly derived agents include one or more of the following: bone (autograft, allograft, and xenograft) and derivates of bone; cartilage (autograft, allograft and xenograft), including, for example, meniscal tissue, and derivatives; ligament (autograft, allograft and xenograft) and derivatives; derivatives of intestinal tissue (autograft, allograft and xenograft), including for example submucosa; derivatives of stomach tissue (autograft, allograft and xenograft), including for example submucosa; derivatives of bladder tissue (autograft, allograft and xenograft), including for example submucosa; derivatives of alimentary tissue (autograft, allograft and xenograft), including for example submucosa; derivatives of respiratory tissue (autograft, allograft and xenograft), including for example submucosa
  • biologically derived agents Purified ECM and other collagen sources are also intended to be included within “biologically derived agents.” If other such substances have therapeutic value in the orthopaedic field, it is anticipated that at least some of these substances will have use in the concepts of the present disclosure, and such substances should be included in the meaning of “biologically-derived agent” and “biologically-derived agents” unless expressly limited otherwise.
  • Bioremodelable collageneous tissue matrices also include bioremodelable collageneous tissue matrices.
  • the expressions “bioremodelable collagenous tissue matrix” and “naturally occurring bioremodelable collageneous tissue matrix” include matrices derived from native tissue selected from the group consisting of skin, artery, vein, pericardium, heart valve, dura mater, ligament, bone, cartilage, bladder, liver, stomach, fascia and intestine, tendon, whatever the source.
  • bioremodelable collageneous tissue matrix is intended to refer to matrix material that has been cleaned, processed, sterilized, and optionally crosslinked, it is not within the definition of a naturally occurring bioremodelable collageneous tissue matrix to purify the natural fibers and reform a matrix material from purified natural fibers.
  • bioremodelable collageneous tissue matrices includes “extracellular matrices” within its definition.
  • Cells include one or more of the following: chondrocytes; fibrochondrocytes; osteocytes; osteoblasts; osteoclasts; synoviocytes; bone marrow cells; mesenchymal cells; stromal cells; stem cells; embryonic stem cells; precursor cells derived from adipose tissue; peripheral blood progenitor cells; stem cells isolated from adult tissue; genetically transformed cells; a combination of chondrocytes and other cells; a combination of osteocytes and other cells; a combination of synoviocytes and other cells; a combination of bone marrow cells and other cells; a combination of mesenchymal cells and other cells; a combination of stromal cells and other cells; a combination of stem cells and other cells; a combination of embryonic stem cells and other cells; a combination of precursor cells isolated from adult tissue and other cells; a combination of peripheral blood progenitor cells and other cells; a combination of stem cells isolated from adult tissue and other cells; and a combination of
  • Bio lubricants include: hyaluronic acid and its salts, such as sodium hyaluronate; glycosaminoglycans such as dermatan sulfate, heparan sulfate, chondroiton sulfate and keratan sulfate; synovial fluid and components of synovial fluid, including as mucinous glycoproteins (e.g. lubricin), vitronectin, tribonectins, articular cartilage superficial zone proteins, surface-active phospholipids, lubricating glycoproteins I, II; and rooster comb hyaluronate.
  • mucinous glycoproteins e.g. lubricin
  • vitronectin e.g. lubricin
  • tribonectins e.g. articular cartilage superficial zone proteins
  • surface-active phospholipids e.g. lubricating glycoproteins I, II
  • Bio lubricant is also intended to include commercial products such as ARTHREASETM high molecular weight sodium hyaluronate, available in Europe from DePuy International, Ltd. of Leeds, England, and manufactured by Bio-Technology General (Israel) Ltd., of Rehovot, Israel; SYNVISC® Hylan G-F 20, manufactured by Biomatrix, Inc., of Ridgefield, New Jersey and distributed by Wyeth-Ayerst Pharmaceuticals of Philadelphia, Pennsylvania; HYLAGAN® sodium hyaluronate, available from Sanofi-Synthelabo, Inc., of New York, New York, manufactured by FIDIA S.p.A., of Padua, Italy; and HEALON® sodium hyaluronate, available from Pharmacia Corporation of Peapack, New Jersey in concentrations of 1%, 1.4% and 2.3% (for opthalmologic uses).
  • ARTHREASETM high molecular weight sodium hyaluronate
  • Biocompatible polymers is intended to include both synthetic polymers and biopolymers (e.g. collagen).
  • biocompatible polymers include: polyesters of [alpha]-hydroxycarboxylic acids, such as poly(L-lactide) (PLLA) and polyglycolide (PGA); poly-p-dioxanone (PDO); polycaprolactone (PCL); polyvinyl alchohol (PVA); polyethylene oxide (PEO); polymers disclosed in U.S.
  • Biocompatible inorganic materials include materials such as hydroxyapatite, all calcium phosphates, alpha-tricalcium phosphate, beta-tricalcium phosphate, calcium carbonate, barium carbonate, calcium sulfate, barium sulfate, polymorphs of calcium phosphate, ceramic particles, and combinations of such materials. If other such substances have therapeutic value in the orthopaedic field, it is anticipated that at least some of these substances will have use in the concepts of the present disclosure, and such substances should be included in the meaning of “biocompatible inorganic material” and “biocompatible inorganic materials” unless expressly limited otherwise.
  • bioactive agents biologically derived agents, cells, biological lubricants, biocompatible inorganic materials, biocompatible polymers can be used with the scaffolds of the present disclosure.
  • a sterilized implant may be subsequently seeded with living cells and packaged in an appropriate medium for the cell type used.
  • a cell culture medium comprising Dulbecco's Modified Eagles Medium (DMEM) can be used with standard additives such as non-essential aminoacids, glucose, ascorbic acid, sodium pyrovate, fungicides, antibiotics, etc., in concentrations deemed appropriate for cell type, shipping conditions, etc.
  • DMEM Dulbecco's Modified Eagles Medium
  • the concepts of the present disclosure provide numerous advantages.
  • the concepts of the present disclosure provide for the fabrication of a porous implantable scaffold which may have varying mechanical properties to fit the needs of a given scaffold design.
  • the pore size and the material density may be varied to produce a scaffold having a desired mechanical configuration.
  • such variation of the pore size and the material density of the scaffold is particularly useful when designing a scaffold which provides for a desired amount of cellular migration therethrough, while also providing a desired amount of structural rigidity.
  • implantable devices can be produced that not only have the appropriate physical microstructure to enable desired cellular activity upon implantation, but also has the biochemistry (collagens, growth factors, glycosaminoglycans, etc.) naturally found in such ECMs.
  • the teachings of the present disclosure can be applied to purified extracellular matrix as well.
  • the naturally occurring extracellular matrix could be purified prior to physically comminuting the extracellular matrix.
  • This purification could comprise treating the naturally occurring extracellular matrix to remove substantially all materials other than collagen prior to physically comminuting the extracellular matrix.
  • the purification could be carried out to substantially remove glycoproteins, glycosaminoglycans, proteoglycans, lipids, non-collagenous proteins and nucleic acids (DNA and RNA).

Abstract

A method of making an implantable scaffold for repairing damaged or diseased tissue includes the step of suspending pieces of an extracellular matrix material in a liquid. The extracellular matrix material and the liquid are formed into a mass. The liquid is subsequently driven off so as to form interstices in the mass. Porous implantable scaffolds fabricated by such a method are also disclosed.

Description

This application claims priority under 35 U.S.C. §119(e) to U.S. Provisional Application No. 60/305,786, filed Jul. 16, 2001; and U.S. Provisional Application No. 60/388,761, filed Jun. 14, 2002, both of which are expressly incorporated by reference herein.
CROSS REFERENCE
Cross reference is made to U.S. patent applications Ser. No. 10/195.794 entitled “Meniscus Regeneration Device and Method”; Ser. No. 10/195,719 entitled “Devices from Naturally Occurring Biologically Derived Materials”; Ser. No. 10/195,347 entitled “Cartilage Repair Apparatus and Method”; Ser. No. 10/195,344 entitled “Unitary Surgical Device and Method”; Ser. No. 10/195,341 entitled “Hybrid Biologic/Synthetic Porous Extracellular Matrix Scaffolds”; Ser. No. 10/195,606 entitled “Cartilage Repair and Regeneration Device and Method”; Ser. No. 10/195,334 entitled “Cartilage Repair and Regeneration Scaffolds and Method”; and Ser. No. 10/195,633 entitled “Porous Delivery Scaffold and Method” each of which is assigned to the same assignee as the present application, each of which is filed concurrently herewith, and each of which is hereby incorporated by reference. Cross reference is also made to U.S. patent application Ser. No. 10/172,347 entitled “Hybrid Biologic-Synthetic Bioabsorbable Scaffolds” which was filed on Jun. 14, 2002, which is assigned to the same assignee as the present application, and which is hereby incorporated by reference.
FIELD OF THE DISCLOSURE
The present disclosure relates generally to an extracellular matrix scaffold, and more particularly to a porous extracellular matrix scaffold for repairing or regenerating body tissue and a method for making such a scaffold.
BACKGROUND
Naturally occurring extracellular matrices (ECMs) are used for tissue repair and regeneration. One such extracellular matrix is small intestine submucosa (SIS). SIS has been used to repair, support, and stabilize a wide variety of anatomical defects and traumatic injuries. Commercially-available SIS material is derived from porcine small intestinal submucosa that remodels to the qualities of its host when implanted in human soft tissues. Further, it is taught that the SIS material provides a natural matrix with a three-dimensional microstructure and biochemical composition that facilitates host cell proliferation and supports tissue remodeling. Indeed, SIS has been shown to contain biological molecules, such as growth factors and glycosaminoglycans that aid in the repair of soft tissue of the human body. The SIS material currently being used in the orthopaedic field is provided in a dried and layered configuration in the form of a patch to repair or regenerate soft tissue such as tendons, ligaments and rotator cuffs.
While small intestine submucosa is readily available, other sources of ECM are known to be effective for tissue remodeling. These sources include, but are not limited to, stomach, bladder, alimentary, respiratory, or genital submucosa, or liver basement membrane. See, e.g., U.S. Pat. Nos. 6,379,710, 6,171,344; 6,099,567; and 5,554,389, each of which is hereby incorporated by reference.
Further, while SIS is most often porcine derived, it is known that various submucosa materials may also be derived from non-porcine sources, including bovine and ovine sources. Additionally, the ECM material may also include partial layers of laminar muscularis mucosa, muscularis mucosa, lamina propria, stratum compactum and/or other such tissue materials depending upon factors such as the source from which the ECM material was derived and the delamination procedure.
As used herein, it is within the definition of a naturally occurring extracellular matrix to clean, delaminate, and/or comminute the extracellular matrix, or to cross-link the collagen or other components within the extracellular matrix. It is also within the definition of naturally occurring extracellular matrix to fully or partially remove one or more components or subcomponents of the naturally occurring matrix. However, it is not within the definition of a naturally occurring extracellular matrix to separate and purify the natural components or subcomponents and reform a matrix material from purified natural components or subcomponents. Thus, while reference is made to SIS, it is understood that other naturally occurring extracellular matrices (e.g. stomach, bladder, alimentary, respiratory, and genital submucosa, and liver basement membrane), whatever the source (e.g. bovine, porcine, ovine) are within the scope of this disclosure. Thus, in this application, the terms “naturally occurring extracellular matrix” or “naturally occurring ECM” are intended to refer to extracellular matrix material that has been cleaned, processed, sterilized, and optionally crosslinked. The following patents, hereby incorporated by reference, disclose the use of ECMs for the regeneration and repair of various tissues: U.S. Pat. Nos. 6,379,710; 6,187,039; 6,176,880; 6,126,686; 6,099,567; 6,096,347; 5,997,575; 5,993,844; 5,968,096; 5,955,110; 5,922,028; 5,885,619; 5,788,625; 5,762,966; 5,755,791; 5,753,267; 5,733,337; 5,711,969; 5,645,860; 5,641,518; 5,554,389; 5,516,533; 5,460,962; 5,445,833; 5,372,821; 5,352,463; 5,281,422; and 5,275,826.
The manipulation of scaffold pore size, porosity, and interconnectivity is an important science contributing to the field of tissue engineering (Ma and Zhang, 2001, J Biomed Mater Res, 56(4):469-477; Ma and Choi, 2001 Tissue Eng, 7(1):23-33) because it is believed that the consideration of scaffold pore size and density/porosity influences the behavior of cells and the quality of tissue regenerated. In fact, several researchers have shown that different pore sizes influence the behavior of cells in porous three-dimensional matrices. For example, it has been demonstrated in the art that for adequate bone regeneration to occur scaffold pore size needs to be at least 100 microns (Klawitter et al., 1976, J Biomed Mater Res, 10(2):311-323). For pore sizes and interconnectivity less than that, poor quality bone is regenerated and if pore size is between 10-40 microns bone cells are able to form only soft fibro-vascular tissue (White and Shors, 1991, Dent Clin North Am, 30:49-67). The consensus of research for bone regeneration indicates that the requisite pore size for bone regeneration is 100-600 microns (Shors, 1999, Orthop Clin North Am, 30(4):599-613; Wang, 1990, Nippon Seikeigeka Gakki Zasshi, 64(9):847-859). It is generally known in the art that optimal bone regeneration occurs for pore sizes between 300-600 microns.
Similarly, for the regeneration of soft orthopaedic tissues, such as ligament, tendon, cartilage, and fibro-cartilage, scaffold pore size is believed to have a substantial effect. For example, basic research has shown that cartilage cells (chondrocytes) exhibit appropriate protein expression (type II collagen) in scaffolds with pore sizes of the order of 20 microns and tend to dedifferentiate to produce type I collagen in scaffolds with nominal porosity of about 80 microns (Nehrer et al., 1997, Biomaterials, 18(11):769-776). More recently, it has been shown that cells that form ligaments, tendons, and blood vessels (fibroblasts and endothelial cells) exhibit significantly different activity when cultured on scaffolds with differing pore sizes ranging from 5 to 90 microns (Salem et al., 2002, J Biomed Mater Res, 61(2):212-217).
SUMMARY
According to one illustrative embodiment, there is provided a method of making an implantable scaffold for repairing damaged or diseased tissue. The method includes the step of suspending, mixing, or otherwise placing pieces of a naturally occurring extracellular matrix material in a liquid. The naturally occurring extracellular matrix material and the liquid are formed into a mass. The liquid is subsequently driven off so as to form interstices in the mass. In one specific implementation of this exemplary embodiment, the liquid is driven off by freeze drying the naturally occurring extracellular matrix material and the liquid in which it is suspended. In such a manner, the liquid is sublimed thereby forming the interstices in the mass.
The material density and pore size of the scaffold may be varied by controlling the rate of freezing of the suspension. The amount of water into which the pieces of naturally occurring extracellular matrix material is suspended may also be varied to control the material density and pore size of the resultant scaffold.
In accordance with another exemplary embodiment, there is provided an implantable scaffold for repairing or regenerating tissue which is prepared by the process described above.
In another aspect, the present disclosure provides an implantable scaffold for repairing or regenerating body tissue. The scaffold comprises a porous body of naturally occurring extracellular matrix pieces that are interconnected to define an interior surface of the body. The interior surface has a three-dimensional topography of irregular shape.
In another aspect, the present disclosure provides an implantable device for repairing or regenerating body tissue. The device comprises a three-dimensional reticulated foam comprising a plurality of interconnected pores. The interconnected pores define three-dimensional interconnected passageways having irregular shapes. At least part of the reticulated foam comprises naturally occurring extracellular matrix.
In another aspect, the present disclosure provides a method of making an implantable device for repairing or regenerating body tissue. The method comprises the steps of providing a naturally occurring extracellular matrix material in a raw form, comminuting the raw naturally occurring extracellular matrix in the presence of a liquid to form a slurry of naturally occurring extracellular matrix, and lyophilizing the slurry of naturally occurring extracellular matrix to form a reticulated foam of naturally occurring extracellular matrix.
In another aspect, the present disclosure provides a method of making an implantable scaffold for repairing or regenerating body tissue. The method comprises the steps of providing a naturally occurring extracellular matrix material in a raw form, comminuting the raw naturally occurring extracellular matrix to form cohesive pieces of naturally occurring extracellular matrix, and lyophilizing the cohesive pieces of naturally occurring extracellular matrix to form a reticulated foam of naturally occurring extracellular matrix.
The implantable devices disclosed herein are three dimensional, porous scaffolds of ECMs like SIS. As such, it is evident that an implant based on the teachings of the present disclosure will have the dual advantage of having not only the appropriate biochemistry (collagens, growth factors, glycosaminoglycans, etc. naturally found in such ECMs) but also the appropriate physical microstructure to enable desired cellular activity upon implantation. These implantable devices are likely to find therapeutic use in the orthopaedic field, for devices used in the treatment of diseased or damaged fibro-cartilage such as the meniscus, diseased or damaged articular cartilage, and diseased or damaged bone.
The above and other features of the present disclosure will become apparent from the following description and the attached drawings.
BRIEF DESCRIPTION OF THE DRAWINGS
The detailed description particularly refers to the accompanying figures in which:
FIG. 1 is an image from a scanning electron microscope which shows the surface of a porous reticulated SIS open cell foam scaffold having a relatively large pore size and a relatively low material density;
FIG. 2 is an image from a scanning electron microscope which shows the surface of a porous reticulated SIS open cell foam scaffold having a relatively moderate pore size and a relatively moderate material density;
FIG. 3 is an image from a scanning electron microscope which shows the surface of a porous reticulated SIS open cell foam scaffold having a relatively small pore size and a relatively high material density;
FIG. 4 is an image from a scanning electron microscope which shows a cross-section of a porous reticulated SIS open cell foam scaffold, with an example of a pore indicated by the arrow, the image being at a greater magnification than the images of FIGS. 1-3;
FIG. 5 is an image from a scanning electron microscope which shows a cross-section of a porous reticulated SIS open cell foam scaffold, with examples of pores indicated by the arrows, the image being at a greater magnification than the images of FIGS. 1-3;
FIG. 6 is an image from a scanning electron microscope which shows a cross-section of a porous reticulated SIS open cell foam scaffold, with examples of pores indicated by the arrows, the image being at a greater magnification than the images of FIGS. 1-3;
FIG. 7 is an image from a scanning electron microscope which shows a cross-section of a porous reticulated SIS open cell foam scaffold, the image being at a greater magnification than the images of FIGS. 1-3;
FIG. 8 is an image from a scanning electron microscope which shows a surface of a porous reticulated SIS open cell foam scaffold, the image being at a greater magnification than the images of FIGS. 1-3; and
FIGS. 9 and 10 are images from a scanning electron microscope which show a mass of cohesive SIS pieces.
DETAILED DESCRIPTION OF THE DRAWINGS
The present disclosure relates to a porous scaffold for implanting into the body of a patient to repair or regenerate damaged or diseased tissue. The porous scaffold is constructed from a naturally occurring extracellular material. For example, the scaffold may be constructed from SIS. As will be discussed herein in greater detail, both the material density and the pore size of the porous scaffold may be varied to fit the needs of a given scaffold design.
Such porous scaffolds may be fabricated by suspending pieces of an extracellular matrix material in a liquid. As used herein, the term “piece” is intended to mean any fiber, strip, ribbon, sliver, filament, shred, bit, fragment, part, flake, slice, cut, chunk, or other portion of solid or solid-like material. Also, as used herein, the term “suspending” is intended to include any placement of a solid (e.g., pieces of ECM) in a liquid whether or not an actual suspension is created. As such, the term “suspending” is intended to include any mixing of a solid in a liquid or any other placement of a solid in a liquid. As a result, the term “suspension” is likewise not intended to be limited to suspensions, but rather is intended to mean any mass having a solid present in a liquid.
In any event, the suspension of the pieces of extracellular matrix material and the liquid forms a mass in the form of, for example, a “slurry”. The liquid may then be subsequently driven off of the mass so as to form interstices therein. The liquid may be driven off in a number of different manners. For example, as will herein be described in greater detail, the liquid may be driven off via sublimation in a freeze drying process. Alternatively, the liquid may also be driven off by subjecting the suspension to either an unheated vacuum process or a vacuum under a controlled heating process. The liquid may also be driven off from the suspension ultrasonically. Microwave energy, RF energy, UV energy, or any other type of energy (or combination thereof) may also be utilized to drive the liquid off of the suspension. Liquid may also be driven off of the suspension by forcing or drawing air through the suspension. The suspension may be centrifuged to drive off the liquid. Moreover, the liquid may include a water-soluble filler which is driven off, for example, by use of an alcohol. In short, the present disclosure contemplates the driving off of the liquid from the suspension by any liquid removal process.
As alluded to above, while any of the aforementioned processes for driving off the liquid from the suspension may be utilized, along with any other process known by one skilled in the art, the processes of the present disclosure will herein be exemplary described in regard to a lyophilization process (i.e., freeze drying). However, it should be understood that such a description is merely exemplary in nature and that any one or more of the aforedescribed processes for driving off the liquid from the suspension may be utilized to fit the needs of a given scaffold design or process design.
As alluded to above, one useful process for fabricating the porous scaffolds of the present disclosure is by lyophilization. In this case, pieces of an extracellular matrix material are suspended in a liquid. The suspension is then frozen and subsequently lyophilized. Freezing the suspension causes the liquid to be turned to ice crystals. These ice crystals are then sublimed under vacuum during the lyophilization process thereby leaving interstices in the material in the spaces previously occupied by the ice crystals. The material density and pore size of the resultant scaffold may be varied by controlling, amongst other things, the rate of freezing of the suspension and/or the amount of water in which the extracellular matrix material is suspended in at the on-set of the freezing process.
As a specific example of this process, fabrication of a porous SIS scaffold by lyophilization will be described in detail. However, it should be appreciated that although the example is herein described in regard to an SIS scaffold, fabrication of a scaffold constructed from other extracellular matrix materials may also be performed in a similar manner.
The first step in fabricating a porous scaffold with a desired pore size and density is the procurement of comminuted SIS. Illustratively, scissor-cut SIS runners (˜6″ long) are positioned in a 1700 series Comitrol™ machine, commercially available from Urschel Laboratories (Valparaiso, Ind.). The SIS material is processed in the presence of a liquid and thereafter collected in a receptacle at the output of the machine. The material is then processed through the machine a second time under similar conditions. In one exemplary process, a liquid (e.g., water) is introduced into the input of the machine contemporaneously with the SIS material. The resultant material is a “slurry” of SIS material (thin, long SIS fibers ˜200 microns thick×1-5 mm long) suspended in a substantially uniform manner in water. Although the suspension is herein described as being formed as a byproduct of the comminuting process, it should be appreciated that the pieces of SIS may be suspended in the liquid (i.e., water) in other manners known to those skilled in the art. Furthermore, while other methods are known for comminuting SIS, it is understood that for the purposes of the present disclosure, comminuted SIS comprises, ribbon-like or string-like fibers wherein at least some of the individual pieces of ECM and SIS material have lengths greater than their widths and thicknesses. Such fibers may be interlaced to provide a felt-like material, if desired.
Process parameters can be varied using the above-identified 1700 series Comitrol™ machine, including the choice of blade used, whether water is used, the amount of water used, the speed at which the blades turn, and the number of times the material is passed through the machine. As an example, cutting head 140084-10 and a Vericut, sealed impeller from Urschel Laboratories may be used, with a flow of water of about two (2) gallons per minute, with the blade running at a constant speed of about 9300 rpm. A first pass through the machine at these parameters will produce fibrous SIS material of varying sizes, and a second pass will produce SIS fibers of a more uniform size. By way of example, the comminuted material may be tested to determine if it has the consistency of that which is desired for use in regard to the illustrative embodiments described herein by the following process: the comminuted SIS suspension or slurry is centrifuged, excess water is poured off and the remaining slurry is poured into a dish. By hand, a small amount of the comminuted SIS material in the dish is pinched between the thumb and index finger and gently lifted from the dish. Illustratively, at least a small amount of additional SIS, beyond the portion pinched between the thumb and index finger, will lift along with the material that has been pinched (“pinch test”). This additional comminuted SIS material lifts with the material that is between the thumb and index finger because the individual pieces of comminuted SIS material are commingled or intertwined.
The terms “cohesive ECM”, “cohesive SIS”, “cohesive ECM pieces” and “cohesive SIS pieces” are used herein to respectively denote ECM or SIS material that has been comminuted or otherwise physically processed to produce ECM or SIS pieces that are capable of comingling or intertwining (in the wet or dry state) to form a mass of discrete pieces of ECM or SIS that remain massed together under some conditions (such as under gravity), regardless of the shape or shapes of the individual ECM or SIS pieces. One method of demonstrating that the ECM or SIS material comprises cohesive pieces is the “pinch test” described in the preceding paragraph. Examination of the final ECM or SIS product produced may also provide evidence that the base material comprised cohesive ECM or SIS pieces. Illustratively, the ECM or SIS pieces are sufficiently cohesive to each other (or to other pieces in the mix or slurry) that they remain unified throughout the process used to produce the foam structure. Examples of cohesive SIS pieces are shown in the scanning electron microscopic images of FIGS. 9 and 10.
Thereafter, the comminuted SIS suspension is frozen and lyophilized (i.e., freeze dried). In particular, the SIS suspension is frozen at a controlled rate of temperature drop to control the size of the formed ice crystals. Once frozen, and without allowing the material to thaw, the lyophilization process sublimes the ice crystals directly to a vapor under vacuum and low temperatures. This leaves voids or interstices in the spaces previously occupied by the ice crystals.
Any commercially available freezer for freezing the suspension to a desired temperature may be used. Likewise, any commercially available lyophilizer may be used for the lyophilization process. One exemplary machine for performing the lyophilization process is a Virtis Genesis™ Series lyophilizer which is commercially available from SP Industries, Inc. of Gardiner, N.Y.
The process parameters of the aforedescribed fabrication process may be varied to produce scaffolds of varying pore sizes and material densities. For example, the rate at which the suspension is frozen, the amount of water present in the suspension, or the compactness of the extracellular matrix material may be varied to produce scaffolds of varying pore sizes and material densities.
For instance, to produce scaffolds having a relatively large pore size and a relatively low material density, the extracellular matrix suspension may be frozen at a slow, controlled rate (e.g., −1° C./min or less) to a temperature of about −20° C., followed by lyophilization of the resultant mass. To produce scaffolds having a relatively small pore size and a relatively high material density, the extracellular matrix material may be tightly compacted by centrifuging the material to remove a portion of the liquid (e.g., water) in a substantially uniform manner prior to freezing. Thereafter, the resultant mass of extracellular matrix material is flash-frozen using liquid nitrogen followed by lyophilization of the mass. To produce scaffolds having a moderate pore size and a moderate material density, the extracellular matrix material is first tightly compacted by centrifuging the material to remove a portion of the liquid (e.g., water) in a substantially uniform manner prior to freezing. Thereafter, the resultant mass of extracellular matrix material is frozen at a relatively fast rate (e.g., >−1° C./min) to a temperature of about −80° C. followed by lyophilization of the mass.
EXAMPLE 1
Example 1 demonstrates the fabrication of a porous SIS scaffold having a relatively large pore size and a relatively low material density. Such scaffolds are obtained by freezing a comminuted SIS suspension at a slow, controlled rate (−1° C./min or less) to −20° C., followed by lyophilization. The procedure is as follows. First, comminuted SIS is fabricated as described above. Specifically, scissor-cut SIS runners (˜6″ long) are placed in a suitable comminuting machine such as the Urschel Comitrol machine described above. The comminuted SIS is collected in a receptacle at the output of the machine. The collected material is then processed through the machine a second time, under the same conditions as before. The resultant mass is a “slurry” of SIS material (thin, long SIS fibers ˜200 microns thick×1-5 mm long) suspended relatively uniformly in water.
Next, a slow-freeze ethanol bath is prepared as follows. Pour enough ethanol to obtain about a 1 centimeter head in a flat-bottomed plastic container large enough to hold four 24-well culture plates. Place the container in a −20° C. freezer. The mass of each of four empty twenty-four well plates is then recorded. Under a sterile hood using sterile conditions, an approximately 3 ml aliquot of the comminuted SIS material is placed in each well of the tissue culture plates. The mass of each full plate of material is then recorded. The four culture plates are then placed into the ethanol freeze bath and allowed to freeze overnight.
The frozen plates are then removed from the ethanol bath and placed in a suitable lyophilization machine such as the Virtis Genesis Series lyophilizer described above. Without allowing the frozen SIS material to thaw, the process of lyophilization sublimes ice crystals directly to vapor under vacuum and low temperatures. This leaves voids or interstices in the spaces previously occupied by the ice crystals. In this case, the parameters used in the lyophilization process include a first period at a primary drying temperature of −13° C. for 8 hours, followed by a second period at a secondary drying temperature of 35° C. for 4 hours.
After the lyophilization cycle is complete, the plates are removed from the lyophilization machine and the mass of each plate is determined and recorded. The results from this process are summarized in the following table:
Average Volume Average Mass Average Density
1.249 ml 0.007396 g 0.006 (g/cc)
A scanning electron image of the surface of the samples was taken to visualize the relative pore sizes. These pore sizes are about 600 microns to about 700 microns. An image indicative of the samples prepared in accordance with Example 1 is shown in FIG. 1.
Pore sizes can be determined from scanning electron microscope images of the exterior surface of the foam, as in FIGS. 1-3 and 8, and of cross-sections of the foam, as in FIGS. 4-7. These images may be used in conjunction with standard commercially available image analysis software to determine the ranges of pore sizes. FIGS. 4-6 illustrate the results of using suitable commercially-available software to measure or estimate the pore sizes in the foam. This technique was used to determine that the Example 1 foam had pores in the range of 600-700 microns. The sample may also include smaller pores.
EXAMPLE 2
Example 2 demonstrates the fabrication of a porous SIS scaffold having a relatively moderate pore size and a relatively moderate material density. Such scaffolds are obtained by compacting the comminuted SIS material by centrifugation, freezing at a faster rate (relative to Example 1) and to a lower temperature (i.e., to −80° C.), followed by lyophilization of the resultant mass. The procedure is as follows. First, comminuted SIS is fabricated as described above in regard to Example 1. Specifically, scissor-cut SIS runners (˜6″ long) is comminuted by two passes through a suitable comminuting machine to produce a “slurry” of SIS material (thin, long SIS fibers ˜200 microns thick×1-5 mm long) suspended relatively uniformly in water.
Next, the mass of each of four empty twenty-four well plates is recorded. Under a sterile hood using sterile conditions, an approximately 3 ml aliquot of the comminuted SIS material is placed in each well of the tissue culture plates. The mass of each plate full of material is then recorded.
The plates are then balanced for centrifuging by use of the following technique. The two plates are placed on the balance, and RO water is added to the area in between the wells of the lighter plate until the two plates are balanced. The two plates are then placed across from one another in the centrifuge, and centrifuged at 3000 rpm for seven minutes. Once done, the plates are removed from the centrifuge, and the water is emptied therefrom. The mass of each of the plates is then recorded. The centrifuging and mass measurement process is then repeated for the remaining plates.
The plates are then placed in a −80° C. freezer until the specimen is fully frozen. Depending upon the bulk of the material, the time for full freezing can vary from about 1 to about 30 minutes, for example. The frozen plates are then removed from the freezer and placed in a suitable lyophilization machine and lyophilized under similar parameters to as described above in regard to Example 1 (i.e., for a first period at a primary drying temperature of −13° C. for 8 hours, followed by a second period at a secondary drying temperature of 35° C. for 4 hours).
After the lyophilization cycle is complete, the plates are removed from the lyophilization machine and the mass of each plate is determined and recorded. The results from this process are summarized in the following table:
Average Volume Average Mass Average Density
0.285 ml 0.010104 g 0.035 (g/cc)
As with the samples of Example 1, a scanning electron image of the surface of each of the samples prepared in accordance with Example 2 was taken to visualize the relative pore sizes. An image indicative of the samples prepared in accordance with Example 2 is shown in FIG. 2. Using the technique described above for determining pore size, this sample was found to have pores in the range of about 100-150 microns.
EXAMPLE 3
Example 3 demonstrates the fabrication of a porous SIS scaffold having a relatively small pore size and a relatively high material density. Such scaffolds are obtained by compacting the comminuted SIS material to an even higher density than in Example 2, flash-freezing the samples using liquid nitrogen, followed by lyophilization. The procedure is as follows. First, comminuted SIS is fabricated as described above in regard to Examples 1 and 2. Specifically, scissor-cut SIS runners (˜6″ long) is comminuted by two passes through a suitable comminuting machine to produce a “slurry” of SIS material (thin, long SIS fibers ˜200 microns thick ×1-5 mm long) suspended relatively uniformly in water. Once done, the resultant mass is centrifuged under a dead-weight. The dead weights are prepared as follows. Forty-eight strips of 3 M™ COBAN™ Self-Adherent Wrap (commercially available from 3 M™ of St. Paul, MN) are cut into pieces that measure 50 mm in length and 5mm in width (unstretched). COBAN™ Self-Adherent Wrap is a laminate of nonwoven material and elastic fibers placed lengthwise to provide elasticity. The elastic wrap contains a cohesive material that makes it stick to itself but not to other materials or skin. Thereafter, the pieces are stretched and wrapped around the outer edges of a polyethylene disk measuring 1 cm in diameter and 2 mm in thickness. Each strip is trimmed, if need be, so that the COBAN™ Self-Adherent Wrap strips wrap around the disk two times.
Next, the mass of each of four empty twenty-four well plates is recorded. Under a sterile hood using sterile conditions, an approximately 3 ml aliquot of the comminuted SIS material is placed in each well of the tissue culture plates. The mass of each full plate of material is then recorded. The plates are then balanced and centrifuged as described above in regard to Example 2. Thereafter, the water is drained from the plates, and the mass of each of the centrifuged plates is recorded.
Once this is completed, the wells of the plates are combined at a ratio of 2:1 thereby reducing the number of plates from four to two. An attempt is made to combine low material wells with high material wells in order to have a somewhat consistent amount of SIS material in each well. The mass of each full plate is then recorded. The polyethylene disks wrapped with COBAN™ Self-Adherent Wrap are then placed into each well. The two plates are then balanced using the technique described above in regard to Example 2. The plates are then centrifuged at 3000 rpm for five minutes. Thereafter, the plates are removed from the centrifuge, the water is emptied therefrom, and the polyethylene disks are also removed. The mass of each plate is again recorded. The two plates are balanced once again (in a manner similar to as described above in regard to Example 2), and the plates are again centrifuged at 3000 rpm for seven minutes. Once done, the water is emptied again from each of the plates, and the mass of each plate is again recorded.
Contemporaneously with the centrifuging process, a liquid nitrogen bath is prepared by pouring liquid nitrogen into a wide-mouthed liquid nitrogen container. The plates are kept in the centrifuge until the bath is ready. Thereafter, each plate is dipped into the bath and held in the liquid for approximately 15 seconds. Upon removal from the nitrogen bath, the plates are immediately placed in a −80° C. freezer to prevent thawing. The frozen plates are then removed from the freezer and placed in a suitable lyophilization machine and lyophilized under similar parameters to as described above in regard to Examples 1 and 2 (i.e., for a first period at a primary drying temperature of −13° C. for 8 hours, followed by a second period at a secondary drying temperature of 35° C. for 4 hours).
After the lyophilization cycle is complete, the plates are removed from the lyophilization machine and the mass of each plate is determined and recorded. The results from this process are summarized in the following table:
Average Volume Average Mass Average Density
0.786 ml 0.071563 g 0.091 (g/cc)
As with the samples of Examples 1 and 2, a scanning electron image of the surface of each of the samples prepared in accordance with Example 3 was taken to visualize the relative pore sizes. An image indicative of the samples prepared in accordance with Example 3 is shown in FIG. 3. Using the technique described above for determining pore size, this sample was found to have pores in the range of about 40-60 microns. Such pore sizes are illustrated in FIGS. 4-6, indicated by the arrows.
As shown in the scanning electron microscope images of FIGS. 1-8, each of the illustrated ECM foams comprises a three-dimensional network of reticulated naturally occurring ECM defining a plurality of interconnected pores. The foam has these pores throughout its height, width, and thickness. The pores are open and interconnected to define a plurality of irregularly-shaped interconnected passageways leading from the exterior surface of the foam (see FIGS. 1-3 and 8) into the interior of the foam (see cross-sections FIGS. 4-7). These interconnected passageways are three-dimensional. As discussed above, the sizes of the pores, and therefore the maximum size for the interconnected passageways, can be controlled by controlling the manufacturing process as described above.
These interconnected passageways facilitate cell migration through the implant and enable efficient nutrient exchange in vivo. These interconnected passageways also provide a means of transmitting bioactive agents, biologically derived substances (e.g. stimulants), cells and/or biological lubricants, biocompatible inorganic materials, synthetic polymers and biopolymers (e.g. collagen) throughout the length, width and thickness of the ECM prior to implantation. The interconnected passageways defined by the pores also serve as passageways for materials used during the manufacturing process, such as compounds used for chemically cross-linking the foam. These interconnected passageways as well as the outer surfaces of the foam may also serve as sites on which the above materials are carried.
As shown in the above examples, the process parameters can be varied to produce an ECM foam that has the desired porosity for the particular application. For example, it may be desirable to produce a foam with lower density (and higher porosity) for applications involving osteocytes and to produce a foam with higher density (and lower porosity) for applications involving chondrocytes.
Moreover, the ECM foams described herein may be crosslinked. Specifically, the ECM foams described herein may be either chemically or physically crosslinked.
As can be seen in the scanning electron microscopic images of FIGS. 1-8, each of the illustrated ECM foams comprises interconnected pieces of naturally occurring extracellular matrix. As shown in the scanning electron microscope images of cross-sections of the ECM foams of FIGS. 4-7, these interconnected pieces of naturally occurring extracellular matrix provide the foam with an interior surface having an three-dimensional topography of irregular shape. As shown in the scanning electron microscope images of the surfaces of the ECM foam, these interconnected pieces of naturally occurring extracellular matrix provide the foam with exterior surfaces having three-dimensional topographies of irregular shapes. With these irregular three-dimensional topographies and the interconnected passageways, the ECM foams of the present disclosure provide a relatively large surface area of naturally occurring ECM. Such a large surface area of naturally occurring ECM can be advantageous in providing a relatively large surface area to which biological agents, biologically derived agents, cells, biocompatible polymers and biocompatible inorganic materials can be affixed pre-implantation. In addition, the illustrated ECM foams provide a relatively large surface of area of naturally occurring ECM to which cells may attach in vivo.
ECM foam products can be made with substantially lower densities than those of other ECM products. For comparison, the density of the commercially available RESTORE® product (DePuy Orthopaedics. Inc. in Warsaw. Ind), an ECM laminate, is 0.466+/−0.074 g/cc. The DePuy product is described for use during rotator cuff surgery. and is provided as a resorbable framework that allows the rotator cuff tendon to regenerate itself. The RESTORE® Implant is derived from porcine small intestine submucosa that has been cleaned. disinfected, and sterilized. An ECM product consisting of comminuted and hardened SIS as described in U.S. patent application Ser. No. 10/195,719 entitled “Devices from Naturally Occurring Biologically Derived Materials”, has been made with a density of can be 0.74+/−0.059 g/cc. And, an ECM product consisting of toughened SIS laminate as described in U.S. patent application Ser. No. 10/195,794 entitled “Meniscus Regeneration Device and Method” has been made with a density of 0.933+/−0.061 g/cc.
As discussed above, the ECM foams of the present disclosure may be combined with bioactive agents, biologically derived substances, cells and/or stimulants, biocompatible inorganic materials and/or biocompatible polymers (e.g. biocompatible synthetic polymers and biopolymers) and combinations of two or more of these materials at the time of manufacture. Illustratively, cells can be seeded throughout the three-dimensional volume of the ECM foam; the biological materials can be dried on the ECM foam at manufacture; the biological materials and the ECM foam can be co-lyophilized; and the biological materials can be covalently linked to the ECM foam. It is contemplated to bond, cross-link, or otherwise incorporate one or more of these materials to the raw ECM material prior to formation of the ECM foam. Alternatively, the materials could be bonded, cross-linked, or otherwise incorporated to the final ECM foam after lyophilization. Finally, combinations of the above methods may be used. For example, an implant of covalently linked ECM foam and biological lubricant can be implanted and additional intra-articular injections of the same or different biological lubricants can be made at surgery, post-operatively, or both at surgery and post-operatively.
“Bioactive agents” include one or more of the following: chemotactic agents; therapeutic agents (e.g. antibiotics, steroidal and non-steroidal analgesics and anti-inflammatories, anti-rejection agents such as immunosuppressants and anti-cancer drugs); various proteins (e.g. short chain peptides, bone morphogenic proteins, glycoprotein and lipoprotein); cell attachment mediators; biologically active ligands; integrin binding sequence; ligands; various growth and/or differentiation agents (e.g. epidermal growth factor, IGF-I, IGF-II, TGF-β I-III, growth and differentiation factors, vascular endothelial growth factors, fibroblast growth factors, platelet derived growth factors, insulin derived growth factor and transforming growth factors, parathyroid hormone, parathyroid hormone related peptide, bFGF; TGFβ superfamily factors; BMP-2; BMP-4; BMP-6; BMP-12; sonic hedgehog; GDF5; GDF6; GDF8; PDGF); small molecules that affect the upregulation of specific growth factors; tenascin-C; hyaluronic acid; chondroitin sulfate; fibronectin; decorin; thromboelastin; thrombin-derived peptides; heparin-binding domains; heparin; heparan sulfate; DNA fragments and DNA plasmids. If other such substances have therapeutic value in the orthopaedic field, it is anticipated that at least some of these substances will have use in concepts of the present disclosure, and such substances should be included in the meaning of “bioactive agent” and “bioactive agents” unless expressly limited otherwise.
“Biologically derived agents” include one or more of the following: bone (autograft, allograft, and xenograft) and derivates of bone; cartilage (autograft, allograft and xenograft), including, for example, meniscal tissue, and derivatives; ligament (autograft, allograft and xenograft) and derivatives; derivatives of intestinal tissue (autograft, allograft and xenograft), including for example submucosa; derivatives of stomach tissue (autograft, allograft and xenograft), including for example submucosa; derivatives of bladder tissue (autograft, allograft and xenograft), including for example submucosa; derivatives of alimentary tissue (autograft, allograft and xenograft), including for example submucosa; derivatives of respiratory tissue (autograft, allograft and xenograft), including for example submucosa; derivatives of genital tissue (autograft, allograft and xenograft), including for example submucosa; derivatives of liver tissue (autograft, allograft and xenograft), including for example liver basement membrane; derivatives of skin tissue; platelet rich plasma (PRP), platelet poor plasma, bone marrow aspirate, demineralized bone matrix, insulin derived growth factor, whole blood, fibrin and blood clot. Purified ECM and other collagen sources are also intended to be included within “biologically derived agents.” If other such substances have therapeutic value in the orthopaedic field, it is anticipated that at least some of these substances will have use in the concepts of the present disclosure, and such substances should be included in the meaning of “biologically-derived agent” and “biologically-derived agents” unless expressly limited otherwise.
“Biologically derived agents” also include bioremodelable collageneous tissue matrices. The expressions “bioremodelable collagenous tissue matrix” and “naturally occurring bioremodelable collageneous tissue matrix” include matrices derived from native tissue selected from the group consisting of skin, artery, vein, pericardium, heart valve, dura mater, ligament, bone, cartilage, bladder, liver, stomach, fascia and intestine, tendon, whatever the source. Although “naturally occurring bioremodelable collageneous tissue matrix” is intended to refer to matrix material that has been cleaned, processed, sterilized, and optionally crosslinked, it is not within the definition of a naturally occurring bioremodelable collageneous tissue matrix to purify the natural fibers and reform a matrix material from purified natural fibers. The term “bioremodelable collageneous tissue matrices” includes “extracellular matrices” within its definition.
“Cells” include one or more of the following: chondrocytes; fibrochondrocytes; osteocytes; osteoblasts; osteoclasts; synoviocytes; bone marrow cells; mesenchymal cells; stromal cells; stem cells; embryonic stem cells; precursor cells derived from adipose tissue; peripheral blood progenitor cells; stem cells isolated from adult tissue; genetically transformed cells; a combination of chondrocytes and other cells; a combination of osteocytes and other cells; a combination of synoviocytes and other cells; a combination of bone marrow cells and other cells; a combination of mesenchymal cells and other cells; a combination of stromal cells and other cells; a combination of stem cells and other cells; a combination of embryonic stem cells and other cells; a combination of precursor cells isolated from adult tissue and other cells; a combination of peripheral blood progenitor cells and other cells; a combination of stem cells isolated from adult tissue and other cells; and a combination of genetically transformed cells and other cells. If other cells are found to have therapeutic value in the orthopaedic field, it is anticipated that at least some of these cells will have use in the concepts of the present disclosure, and such cells should be included within the meaning of “cell” and “cells” unless expressly limited otherwise.
“Biological lubricants” include: hyaluronic acid and its salts, such as sodium hyaluronate; glycosaminoglycans such as dermatan sulfate, heparan sulfate, chondroiton sulfate and keratan sulfate; synovial fluid and components of synovial fluid, including as mucinous glycoproteins (e.g. lubricin), vitronectin, tribonectins, articular cartilage superficial zone proteins, surface-active phospholipids, lubricating glycoproteins I, II; and rooster comb hyaluronate. “Biological lubricant” is also intended to include commercial products such as ARTHREASE™ high molecular weight sodium hyaluronate, available in Europe from DePuy International, Ltd. of Leeds, England, and manufactured by Bio-Technology General (Israel) Ltd., of Rehovot, Israel; SYNVISC® Hylan G-F 20, manufactured by Biomatrix, Inc., of Ridgefield, New Jersey and distributed by Wyeth-Ayerst Pharmaceuticals of Philadelphia, Pennsylvania; HYLAGAN® sodium hyaluronate, available from Sanofi-Synthelabo, Inc., of New York, New York, manufactured by FIDIA S.p.A., of Padua, Italy; and HEALON® sodium hyaluronate, available from Pharmacia Corporation of Peapack, New Jersey in concentrations of 1%, 1.4% and 2.3% (for opthalmologic uses). If other such substances have therapeutic value in the orthopaedic field, it is anticipated that at least some of these substances will have use in the concepts of the present disclosure, and such substances should be included in the meaning of “biological lubricant” and “biological lubricants” unless expressly limited otherwise. “Biocompatible polymers” is intended to include both synthetic polymers and biopolymers (e.g. collagen). Examples of biocompatible polymers include: polyesters of [alpha]-hydroxycarboxylic acids, such as poly(L-lactide) (PLLA) and polyglycolide (PGA); poly-p-dioxanone (PDO); polycaprolactone (PCL); polyvinyl alchohol (PVA); polyethylene oxide (PEO); polymers disclosed in U.S. Pat. Nos. 6,333,029 and 6,355,699; and any other bioresorbable and biocompatible polymer, co-polymer or mixture of polymers or co-polymers that are utilized in the construction of prosthetic implants. In addition, as new biocompatible, bioresorbable materials are developed, it is expected that at least some of them will be useful materials from which orthopaedic devices may be made. It should be understood that the above materials are identified by way of example only, and the present invention is not limited to any particular material unless expressly called for in the claims.
“Biocompatible inorganic materials” include materials such as hydroxyapatite, all calcium phosphates, alpha-tricalcium phosphate, beta-tricalcium phosphate, calcium carbonate, barium carbonate, calcium sulfate, barium sulfate, polymorphs of calcium phosphate, ceramic particles, and combinations of such materials. If other such substances have therapeutic value in the orthopaedic field, it is anticipated that at least some of these substances will have use in the concepts of the present disclosure, and such substances should be included in the meaning of “biocompatible inorganic material” and “biocompatible inorganic materials” unless expressly limited otherwise.
It is expected that various combinations of bioactive agents, biologically derived agents, cells, biological lubricants, biocompatible inorganic materials, biocompatible polymers can be used with the scaffolds of the present disclosure.
It is expected that standard sterilization techniques may be used with the products of the present disclosure.
Illustratively, in one example of embodiments that are to be seeded with living cells such as chondrocytes, a sterilized implant may be subsequently seeded with living cells and packaged in an appropriate medium for the cell type used. For example, a cell culture medium comprising Dulbecco's Modified Eagles Medium (DMEM) can be used with standard additives such as non-essential aminoacids, glucose, ascorbic acid, sodium pyrovate, fungicides, antibiotics, etc., in concentrations deemed appropriate for cell type, shipping conditions, etc.
It is anticipated that the ECM foams of the present disclosure may be combined with the concepts disclosed in the following applications for U.S. patent, filed concurrently herewith, which are incorporated by reference herein in their entireties: Ser. No. 10/195,794 entitled “Meniscus Regeneration Device and Method”; Ser. No. 10/195,719 entitled “Devices from Naturally Occurring Biologically Derived Materials”; Ser. No. 10/195,347 entitled “Cartilage Repair Apparatus and Method”; Ser. No. 10/195,344 entitled “Unitary Surgical Device and Method”; Ser. No. 10/195,341 entitled “Hybrid Biologic/Synthetic Porous Extracellular Matrix Scaffolds”; Ser. No. 10/195,606 entitled “Cartilage Repair and Regeneration Device and Method” Ser. No. 10/195,334 entitled “Cartilage Repair and Regeneration Scaffolds and Method”; and Ser. No. 10/195,633 entitled “Porous Delivery Scaffold and Method”, along with U.S. patent application Ser. No. 10/172,347 entitled “Hybrid Biologic-Synthetic Bioabsorbable Scaffolds” which was filed on Jun. 14, 2002. For example, for orthopaedic uses, it may be desirable to accompany or follow implantation with a treatment regime involving administering hyaluronic acid to the implantation site.
As can be seen from the forgoing description, the concepts of the present disclosure provide numerous advantages. For example, the concepts of the present disclosure provide for the fabrication of a porous implantable scaffold which may have varying mechanical properties to fit the needs of a given scaffold design. For instance, the pore size and the material density may be varied to produce a scaffold having a desired mechanical configuration. In particular, such variation of the pore size and the material density of the scaffold is particularly useful when designing a scaffold which provides for a desired amount of cellular migration therethrough, while also providing a desired amount of structural rigidity. In addition, according to the concepts of the present disclosure, implantable devices can be produced that not only have the appropriate physical microstructure to enable desired cellular activity upon implantation, but also has the biochemistry (collagens, growth factors, glycosaminoglycans, etc.) naturally found in such ECMs.
Although it is believed that naturally occurring extracellular matrix provides advantages over purified extracellular matrix, it is contemplated that the teachings of the present disclosure can be applied to purified extracellular matrix as well. Thus, it is expected that the naturally occurring extracellular matrix could be purified prior to physically comminuting the extracellular matrix. This purification could comprise treating the naturally occurring extracellular matrix to remove substantially all materials other than collagen prior to physically comminuting the extracellular matrix. The purification could be carried out to substantially remove glycoproteins, glycosaminoglycans, proteoglycans, lipids, non-collagenous proteins and nucleic acids (DNA and RNA).
While the disclosure is susceptible to various modifications and alternative forms, specific exemplary embodiments thereof have been shown by way of example in the drawings and has herein be described in detail. It should be understood, however, that there is no intent to limit the disclosure to the particular forms disclosed, but on the contrary, the intention is to cover all modifications, equivalents, and alternatives falling within the spirit and scope of the disclosure.
There are a plurality of advantages of the present disclosure arising from the various features of the apparatus and methods described herein. It will be noted that alternative embodiments of the apparatus and methods of the present disclosure may not include all of the features described yet still benefit from at least some of the advantages of such features. Those of ordinary skill in the art may readily devise their own implementations of an apparatus and method that incorporate one or more of the features of the present disclosure and fall within the spirit and scope of the present disclosure.

Claims (10)

1. A method of making an implantable scaffold for repairing or regenerating body tissue, the method comprising the steps of:
cutting naturally occurring extracellular matrix material in the presence of a liquid to produce a cohesive mass of intertwined strips, ribbons, or fibers; and
freeze drying the cohesive mass to form a porous structure.
2. The method of claim 1, further comprising the step of freezing the cohesive mass to form a frozen composition, said frozen composition comprising ice crystals, the freezing step being performed prior to the freeze drying step.
3. The method of claim 1, wherein the extracellular matrix material comprises material selected from the group consisting of: small intestine submucosa, bladder submucosa, stomach submucosa, alimentary submucosa, respiratory submucosa, genital submucosa, and liver basement membrane.
4. The method of claim 1, further comprising the step of flashfreezing the cohesive mass prior to the freeze drying step.
5. The method of claim 1, further comprising the step of compacting the cohesive mass prior to the freeze drying step.
6. The method of claim 1, further comprising the step of centrifuging the cohesive mass prior to the freeze drying step.
7. The method of claim 1, further comprising the step of freezing the cohesive mass at a controlled rate of temperature drop.
8. A method of making an implantable scaffold for repairing or regenerating body tissue, the method comprising the steps of:
providing a naturally occurring extracellular matrix material selected from the group consisting of: small intestine submucosa, stomach submucosa, bladder submucosa, respiratory submucosa, alimentary submucosa, genital submucosa, and liver basement membrane;
cutting the naturally occurring extracellular matrix material in the presence of a liquid to produce a cohesive mass of intertwined strips, ribbons, or fibers; and
freeze drying the cohesive mass to form a porous structure.
9. A method of making an implantable scaffold for repairing or regenerating body tissue, the method comprising the steps of:
cutting naturally occurring extracellular matrix material in the presence of a liquid to produce a cohesive mass of intertwined strips, ribbons, or fibers,
freezing the cohesive mass at a controlled rate of temperature drop, and
freeze drying the cohesive mass to form a porous structure,
wherein the cohesive mass is frozen by reducing the temperature of the naturally occurring extracellular matrix at a rate of −1° C./min or less.
10. A method of making an implantable scaffold for repairing or regenerating body tissue, the method comprising the steps of:
cutting naturally occurring extracellular matrix material in the presence of a liquid to produce a cohesive mass of intertwined strips, ribbons, or fibers,
freezing the cohesive mass at a controlled rate of temperature drop, and
freeze drying the cohesive mass to form a porous structure,
wherein the cohesive mass is frozen by reducing the temperature of the naturally occurring extracellular matrix at a rate of greater than −1° C./min.
US10/195,354 2001-07-16 2002-07-15 Porous extracellular matrix scaffold and method Active 2025-09-29 US8025896B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
US10/195,354 US8025896B2 (en) 2001-07-16 2002-07-15 Porous extracellular matrix scaffold and method

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US30578601P 2001-07-16 2001-07-16
US38876102P 2002-06-14 2002-06-14
US39248702P 2002-06-29 2002-06-29
US10/195,354 US8025896B2 (en) 2001-07-16 2002-07-15 Porous extracellular matrix scaffold and method

Publications (2)

Publication Number Publication Date
US20030044444A1 US20030044444A1 (en) 2003-03-06
US8025896B2 true US8025896B2 (en) 2011-09-27

Family

ID=32330020

Family Applications (1)

Application Number Title Priority Date Filing Date
US10/195,354 Active 2025-09-29 US8025896B2 (en) 2001-07-16 2002-07-15 Porous extracellular matrix scaffold and method

Country Status (1)

Country Link
US (1) US8025896B2 (en)

Cited By (398)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20100161054A1 (en) * 2008-11-21 2010-06-24 Jason Park Reinforced Biologic Material
US20100222882A1 (en) * 2009-02-27 2010-09-02 Badylak Stephen F Joint bioscaffolds
WO2013062995A1 (en) 2011-10-25 2013-05-02 Biomimetic Therapeutics, Inc. Compositions and methods for treating deep partial and full thickness wounds and injuries
WO2013062994A1 (en) 2011-10-25 2013-05-02 Biomimetic Therapeutics, Inc. Compositions and methods for treating full thickness burn injuries
US8632489B1 (en) 2011-12-22 2014-01-21 A. Mateen Ahmed Implantable medical assembly and methods
US9113954B2 (en) 2004-10-29 2015-08-25 DePuy Synthes Products, Inc. Coordinate instrument set
US9119728B2 (en) 2011-01-17 2015-09-01 Cibor, Inc. Reinforced carbon fiber/carbon foam intervertebral spine fusion device
US9238090B1 (en) 2014-12-24 2016-01-19 Fettech, Llc Tissue-based compositions
US9289452B2 (en) 2013-03-07 2016-03-22 Allosource Consistent calcium content bone allograft systems and methods
US20160089477A1 (en) * 2014-09-25 2016-03-31 Acell, Inc. Porous foams derived from extracellular matrix, porous foam ecm medical devices, and methods of use and making thereof
US9339387B2 (en) 2010-10-13 2016-05-17 Cibor, Inc. Synthetic bone grafts constructed from carbon foam materials
US9364328B2 (en) 2011-11-17 2016-06-14 Allosource Multi-piece machine graft systems and methods
US9381112B1 (en) 2011-10-06 2016-07-05 William Eric Sponsell Bleb drainage device, ophthalmological product and methods
US9603710B2 (en) 2013-03-15 2017-03-28 Allosource Methods of manufacturing perforated osteochondral allograft compositions
US9730796B2 (en) 2014-05-16 2017-08-15 Allosource Composite bone constructs and methods
US9744266B2 (en) 2011-12-19 2017-08-29 Allosource Flowable matrix compositions and methods
US9808558B2 (en) 2008-11-20 2017-11-07 Allosource Allografts combined with tissue derived stem cells for bone healing
US10071182B2 (en) 2014-10-14 2018-09-11 Samuel E. Lynch Methods for treating wounds
US10245032B2 (en) 2005-08-31 2019-04-02 Ethicon Llc Staple cartridges for forming staples having differing formed staple heights
US10265067B2 (en) 2008-02-14 2019-04-23 Ethicon Llc Surgical instrument including a regulator and a control system
US10271849B2 (en) 2015-09-30 2019-04-30 Ethicon Llc Woven constructs with interlocked standing fibers
US10278702B2 (en) 2004-07-28 2019-05-07 Ethicon Llc Stapling system comprising a firing bar and a lockout
US10278697B2 (en) 2005-08-31 2019-05-07 Ethicon Llc Staple cartridge comprising a staple driver arrangement
US10285695B2 (en) 2013-03-01 2019-05-14 Ethicon Llc Articulatable surgical instruments with conductive pathways
US10292704B2 (en) 2015-12-30 2019-05-21 Ethicon Llc Mechanisms for compensating for battery pack failure in powered surgical instruments
US10293100B2 (en) 2004-07-28 2019-05-21 Ethicon Llc Surgical stapling instrument having a medical substance dispenser
US10299817B2 (en) 2006-01-31 2019-05-28 Ethicon Llc Motor-driven fastening assembly
US10299792B2 (en) 2014-04-16 2019-05-28 Ethicon Llc Fastener cartridge comprising non-uniform fasteners
US10299878B2 (en) 2015-09-25 2019-05-28 Ethicon Llc Implantable adjunct systems for determining adjunct skew
US10299787B2 (en) 2007-06-04 2019-05-28 Ethicon Llc Stapling system comprising rotary inputs
US10307170B2 (en) 2017-06-20 2019-06-04 Ethicon Llc Method for closed loop control of motor velocity of a surgical stapling and cutting instrument
US10307163B2 (en) 2008-02-14 2019-06-04 Ethicon Llc Detachable motor powered surgical instrument
US10307160B2 (en) 2015-09-30 2019-06-04 Ethicon Llc Compressible adjunct assemblies with attachment layers
US10327764B2 (en) 2014-09-26 2019-06-25 Ethicon Llc Method for creating a flexible staple line
US10327767B2 (en) 2017-06-20 2019-06-25 Ethicon Llc Control of motor velocity of a surgical stapling and cutting instrument based on angle of articulation
US10327769B2 (en) 2015-09-23 2019-06-25 Ethicon Llc Surgical stapler having motor control based on a drive system component
US10335281B2 (en) 2013-02-22 2019-07-02 Allosource Cartilage mosaic compositions and methods
US10335148B2 (en) 2010-09-30 2019-07-02 Ethicon Llc Staple cartridge including a tissue thickness compensator for a surgical stapler
US10335150B2 (en) 2010-09-30 2019-07-02 Ethicon Llc Staple cartridge comprising an implantable layer
US10335145B2 (en) 2016-04-15 2019-07-02 Ethicon Llc Modular surgical instrument with configurable operating mode
US10335151B2 (en) 2011-05-27 2019-07-02 Ethicon Llc Robotically-driven surgical instrument
USD854151S1 (en) 2017-06-28 2019-07-16 Ethicon Llc Surgical instrument shaft
US10357247B2 (en) 2016-04-15 2019-07-23 Ethicon Llc Surgical instrument with multiple program responses during a firing motion
US10363037B2 (en) 2016-04-18 2019-07-30 Ethicon Llc Surgical instrument system comprising a magnetic lockout
US10363031B2 (en) 2010-09-30 2019-07-30 Ethicon Llc Tissue thickness compensators for surgical staplers
US10368864B2 (en) 2017-06-20 2019-08-06 Ethicon Llc Systems and methods for controlling displaying motor velocity for a surgical instrument
US10368865B2 (en) 2015-12-30 2019-08-06 Ethicon Llc Mechanisms for compensating for drivetrain failure in powered surgical instruments
US10376263B2 (en) 2016-04-01 2019-08-13 Ethicon Llc Anvil modification members for surgical staplers
US10383630B2 (en) 2012-06-28 2019-08-20 Ethicon Llc Surgical stapling device with rotary driven firing member
US10398434B2 (en) 2017-06-29 2019-09-03 Ethicon Llc Closed loop velocity control of closure member for robotic surgical instrument
US10398433B2 (en) 2007-03-28 2019-09-03 Ethicon Llc Laparoscopic clamp load measuring devices
US10405859B2 (en) 2016-04-15 2019-09-10 Ethicon Llc Surgical instrument with adjustable stop/start control during a firing motion
US10413294B2 (en) 2012-06-28 2019-09-17 Ethicon Llc Shaft assembly arrangements for surgical instruments
US10413291B2 (en) 2016-02-09 2019-09-17 Ethicon Llc Surgical instrument articulation mechanism with slotted secondary constraint
US10420550B2 (en) 2009-02-06 2019-09-24 Ethicon Llc Motor driven surgical fastener device with switching system configured to prevent firing initiation until activated
US10420560B2 (en) 2006-06-27 2019-09-24 Ethicon Llc Manually driven surgical cutting and fastening instrument
US10420549B2 (en) 2008-09-23 2019-09-24 Ethicon Llc Motorized surgical instrument
US10426471B2 (en) 2016-12-21 2019-10-01 Ethicon Llc Surgical instrument with multiple failure response modes
US10426467B2 (en) 2016-04-15 2019-10-01 Ethicon Llc Surgical instrument with detection sensors
US10426481B2 (en) 2014-02-24 2019-10-01 Ethicon Llc Implantable layer assemblies
US10426463B2 (en) 2006-01-31 2019-10-01 Ehticon LLC Surgical instrument having a feedback system
US10433844B2 (en) 2015-03-31 2019-10-08 Ethicon Llc Surgical instrument with selectively disengageable threaded drive systems
US10441281B2 (en) 2013-08-23 2019-10-15 Ethicon Llc surgical instrument including securing and aligning features
US10441279B2 (en) 2015-03-06 2019-10-15 Ethicon Llc Multiple level thresholds to modify operation of powered surgical instruments
US10441285B2 (en) 2012-03-28 2019-10-15 Ethicon Llc Tissue thickness compensator comprising tissue ingrowth features
US10448952B2 (en) 2006-09-29 2019-10-22 Ethicon Llc End effector for use with a surgical fastening instrument
US10448950B2 (en) 2016-12-21 2019-10-22 Ethicon Llc Surgical staplers with independently actuatable closing and firing systems
US10456137B2 (en) 2016-04-15 2019-10-29 Ethicon Llc Staple formation detection mechanisms
US10463370B2 (en) 2008-02-14 2019-11-05 Ethicon Llc Motorized surgical instrument
US10485543B2 (en) 2016-12-21 2019-11-26 Ethicon Llc Anvil having a knife slot width
US10485539B2 (en) 2006-01-31 2019-11-26 Ethicon Llc Surgical instrument with firing lockout
US10492783B2 (en) 2016-04-15 2019-12-03 Ethicon, Llc Surgical instrument with improved stop/start control during a firing motion
US10492785B2 (en) 2016-12-21 2019-12-03 Ethicon Llc Shaft assembly comprising a lockout
US10499914B2 (en) 2016-12-21 2019-12-10 Ethicon Llc Staple forming pocket arrangements
USD869655S1 (en) 2017-06-28 2019-12-10 Ethicon Llc Surgical fastener cartridge
US10517590B2 (en) 2007-01-10 2019-12-31 Ethicon Llc Powered surgical instrument having a transmission system
US10517595B2 (en) 2016-12-21 2019-12-31 Ethicon Llc Jaw actuated lock arrangements for preventing advancement of a firing member in a surgical end effector unless an unfired cartridge is installed in the end effector
US10517682B2 (en) 2007-01-10 2019-12-31 Ethicon Llc Surgical instrument with wireless communication between control unit and remote sensor
US10524787B2 (en) 2015-03-06 2020-01-07 Ethicon Llc Powered surgical instrument with parameter-based firing rate
US10524790B2 (en) 2011-05-27 2020-01-07 Ethicon Llc Robotically-controlled surgical stapling devices that produce formed staples having different lengths
US10531887B2 (en) 2015-03-06 2020-01-14 Ethicon Llc Powered surgical instrument including speed display
US10537325B2 (en) 2016-12-21 2020-01-21 Ethicon Llc Staple forming pocket arrangement to accommodate different types of staples
US10548504B2 (en) 2015-03-06 2020-02-04 Ethicon Llc Overlaid multi sensor radio frequency (RF) electrode system to measure tissue compression
US10548600B2 (en) 2010-09-30 2020-02-04 Ethicon Llc Multiple thickness implantable layers for surgical stapling devices
US10568625B2 (en) 2016-12-21 2020-02-25 Ethicon Llc Staple cartridges and arrangements of staples and staple cavities therein
US10568652B2 (en) 2006-09-29 2020-02-25 Ethicon Llc Surgical staples having attached drivers of different heights and stapling instruments for deploying the same
US10568626B2 (en) 2016-12-21 2020-02-25 Ethicon Llc Surgical instruments with jaw opening features for increasing a jaw opening distance
US10575868B2 (en) 2013-03-01 2020-03-03 Ethicon Llc Surgical instrument with coupler assembly
US10588626B2 (en) 2014-03-26 2020-03-17 Ethicon Llc Surgical instrument displaying subsequent step of use
US10588623B2 (en) 2010-09-30 2020-03-17 Ethicon Llc Adhesive film laminate
US10588632B2 (en) 2016-12-21 2020-03-17 Ethicon Llc Surgical end effectors and firing members thereof
US10588633B2 (en) 2017-06-28 2020-03-17 Ethicon Llc Surgical instruments with open and closable jaws and axially movable firing member that is initially parked in close proximity to the jaws prior to firing
USD879809S1 (en) 2017-06-20 2020-03-31 Ethicon Llc Display panel with changeable graphical user interface
USD879808S1 (en) 2017-06-20 2020-03-31 Ethicon Llc Display panel with graphical user interface
US10617412B2 (en) 2015-03-06 2020-04-14 Ethicon Llc System for detecting the mis-insertion of a staple cartridge into a surgical stapler
US10617418B2 (en) 2015-08-17 2020-04-14 Ethicon Llc Implantable layers for a surgical instrument
US10617417B2 (en) 2014-11-06 2020-04-14 Ethicon Llc Staple cartridge comprising a releasable adjunct material
US10617416B2 (en) 2013-03-14 2020-04-14 Ethicon Llc Control systems for surgical instruments
US10617413B2 (en) 2016-04-01 2020-04-14 Ethicon Llc Closure system arrangements for surgical cutting and stapling devices with separate and distinct firing shafts
US10617420B2 (en) 2011-05-27 2020-04-14 Ethicon Llc Surgical system comprising drive systems
US10624861B2 (en) 2010-09-30 2020-04-21 Ethicon Llc Tissue thickness compensator configured to redistribute compressive forces
US10624633B2 (en) 2017-06-20 2020-04-21 Ethicon Llc Systems and methods for controlling motor velocity of a surgical stapling and cutting instrument
US10631859B2 (en) 2017-06-27 2020-04-28 Ethicon Llc Articulation systems for surgical instruments
US10639115B2 (en) 2012-06-28 2020-05-05 Ethicon Llc Surgical end effectors having angled tissue-contacting surfaces
US10646220B2 (en) 2017-06-20 2020-05-12 Ethicon Llc Systems and methods for controlling displacement member velocity for a surgical instrument
US10660640B2 (en) 2008-02-14 2020-05-26 Ethicon Llc Motorized surgical cutting and fastening instrument
US10667808B2 (en) 2012-03-28 2020-06-02 Ethicon Llc Staple cartridge comprising an absorbable adjunct
US10667809B2 (en) 2016-12-21 2020-06-02 Ethicon Llc Staple cartridge and staple cartridge channel comprising windows defined therein
US10675028B2 (en) 2006-01-31 2020-06-09 Ethicon Llc Powered surgical instruments with firing system lockout arrangements
US10682134B2 (en) 2017-12-21 2020-06-16 Ethicon Llc Continuous use self-propelled stapling instrument
US10682142B2 (en) 2008-02-14 2020-06-16 Ethicon Llc Surgical stapling apparatus including an articulation system
US10687813B2 (en) 2017-12-15 2020-06-23 Ethicon Llc Adapters with firing stroke sensing arrangements for use in connection with electromechanical surgical instruments
US10687806B2 (en) 2015-03-06 2020-06-23 Ethicon Llc Adaptive tissue compression techniques to adjust closure rates for multiple tissue types
US10695062B2 (en) 2010-10-01 2020-06-30 Ethicon Llc Surgical instrument including a retractable firing member
US10695063B2 (en) 2012-02-13 2020-06-30 Ethicon Llc Surgical cutting and fastening instrument with apparatus for determining cartridge and firing motion status
US10695058B2 (en) 2014-12-18 2020-06-30 Ethicon Llc Surgical instrument systems comprising an articulatable end effector and means for adjusting the firing stroke of a firing member
US10702266B2 (en) 2013-04-16 2020-07-07 Ethicon Llc Surgical instrument system
US10702267B2 (en) 2007-03-15 2020-07-07 Ethicon Llc Surgical stapling instrument having a releasable buttress material
US10716565B2 (en) 2017-12-19 2020-07-21 Ethicon Llc Surgical instruments with dual articulation drivers
USD890784S1 (en) 2017-06-20 2020-07-21 Ethicon Llc Display panel with changeable graphical user interface
US10716614B2 (en) 2017-06-28 2020-07-21 Ethicon Llc Surgical shaft assemblies with slip ring assemblies with increased contact pressure
US10729509B2 (en) 2017-12-19 2020-08-04 Ethicon Llc Surgical instrument comprising closure and firing locking mechanism
US10729501B2 (en) 2017-09-29 2020-08-04 Ethicon Llc Systems and methods for language selection of a surgical instrument
US10736628B2 (en) 2008-09-23 2020-08-11 Ethicon Llc Motor-driven surgical cutting instrument
US10736636B2 (en) 2014-12-10 2020-08-11 Ethicon Llc Articulatable surgical instrument system
US10736630B2 (en) 2014-10-13 2020-08-11 Ethicon Llc Staple cartridge
US10743875B2 (en) 2017-12-15 2020-08-18 Ethicon Llc Surgical end effectors with jaw stiffener arrangements configured to permit monitoring of firing member
US10743851B2 (en) 2008-02-14 2020-08-18 Ethicon Llc Interchangeable tools for surgical instruments
US10743874B2 (en) 2017-12-15 2020-08-18 Ethicon Llc Sealed adapters for use with electromechanical surgical instruments
US10743873B2 (en) 2014-12-18 2020-08-18 Ethicon Llc Drive arrangements for articulatable surgical instruments
US10743849B2 (en) 2006-01-31 2020-08-18 Ethicon Llc Stapling system including an articulation system
US10743872B2 (en) 2017-09-29 2020-08-18 Ethicon Llc System and methods for controlling a display of a surgical instrument
US10743870B2 (en) 2008-02-14 2020-08-18 Ethicon Llc Surgical stapling apparatus with interlockable firing system
US10751076B2 (en) 2009-12-24 2020-08-25 Ethicon Llc Motor-driven surgical cutting instrument with electric actuator directional control assembly
US10758230B2 (en) 2016-12-21 2020-09-01 Ethicon Llc Surgical instrument with primary and safety processors
US10758229B2 (en) 2016-12-21 2020-09-01 Ethicon Llc Surgical instrument comprising improved jaw control
US10765429B2 (en) 2017-09-29 2020-09-08 Ethicon Llc Systems and methods for providing alerts according to the operational state of a surgical instrument
US10765427B2 (en) 2017-06-28 2020-09-08 Ethicon Llc Method for articulating a surgical instrument
US10765425B2 (en) 2008-09-23 2020-09-08 Ethicon Llc Robotically-controlled motorized surgical instrument with an end effector
US10772625B2 (en) 2015-03-06 2020-09-15 Ethicon Llc Signal and power communication system positioned on a rotatable shaft
US10772629B2 (en) 2017-06-27 2020-09-15 Ethicon Llc Surgical anvil arrangements
US10779825B2 (en) 2017-12-15 2020-09-22 Ethicon Llc Adapters with end effector position sensing and control arrangements for use in connection with electromechanical surgical instruments
US10779903B2 (en) 2017-10-31 2020-09-22 Ethicon Llc Positive shaft rotation lock activated by jaw closure
US10779821B2 (en) 2018-08-20 2020-09-22 Ethicon Llc Surgical stapler anvils with tissue stop features configured to avoid tissue pinch
US10779826B2 (en) 2017-12-15 2020-09-22 Ethicon Llc Methods of operating surgical end effectors
US10779820B2 (en) 2017-06-20 2020-09-22 Ethicon Llc Systems and methods for controlling motor speed according to user input for a surgical instrument
US10780539B2 (en) 2011-05-27 2020-09-22 Ethicon Llc Stapling instrument for use with a robotic system
US10779824B2 (en) 2017-06-28 2020-09-22 Ethicon Llc Surgical instrument comprising an articulation system lockable by a closure system
US10796471B2 (en) 2017-09-29 2020-10-06 Ethicon Llc Systems and methods of displaying a knife position for a surgical instrument
US10806448B2 (en) 2014-12-18 2020-10-20 Ethicon Llc Surgical instrument assembly comprising a flexible articulation system
US10806449B2 (en) 2005-11-09 2020-10-20 Ethicon Llc End effectors for surgical staplers
US10813639B2 (en) 2017-06-20 2020-10-27 Ethicon Llc Closed loop feedback control of motor velocity of a surgical stapling and cutting instrument based on system conditions
US10828028B2 (en) 2016-04-15 2020-11-10 Ethicon Llc Surgical instrument with multiple program responses during a firing motion
US10828033B2 (en) 2017-12-15 2020-11-10 Ethicon Llc Handheld electromechanical surgical instruments with improved motor control arrangements for positioning components of an adapter coupled thereto
US10835330B2 (en) 2017-12-19 2020-11-17 Ethicon Llc Method for determining the position of a rotatable jaw of a surgical instrument attachment assembly
US10842490B2 (en) 2017-10-31 2020-11-24 Ethicon Llc Cartridge body design with force reduction based on firing completion
US10842488B2 (en) 2005-08-31 2020-11-24 Ethicon Llc Fastener cartridge assembly comprising a fixed anvil and different staple heights
US10842492B2 (en) 2018-08-20 2020-11-24 Ethicon Llc Powered articulatable surgical instruments with clutching and locking arrangements for linking an articulation drive system to a firing drive system
US10842491B2 (en) 2006-01-31 2020-11-24 Ethicon Llc Surgical system with an actuation console
US10856870B2 (en) 2018-08-20 2020-12-08 Ethicon Llc Switching arrangements for motor powered articulatable surgical instruments
US10856869B2 (en) 2017-06-27 2020-12-08 Ethicon Llc Surgical anvil arrangements
US10863986B2 (en) 2015-09-23 2020-12-15 Ethicon Llc Surgical stapler having downstream current-based motor control
US10869666B2 (en) 2017-12-15 2020-12-22 Ethicon Llc Adapters with control systems for controlling multiple motors of an electromechanical surgical instrument
USD906355S1 (en) 2017-06-28 2020-12-29 Ethicon Llc Display screen or portion thereof with a graphical user interface for a surgical instrument
US10881399B2 (en) 2017-06-20 2021-01-05 Ethicon Llc Techniques for adaptive control of motor velocity of a surgical stapling and cutting instrument
US10881396B2 (en) 2017-06-20 2021-01-05 Ethicon Llc Surgical instrument with variable duration trigger arrangement
USD907647S1 (en) 2017-09-29 2021-01-12 Ethicon Llc Display screen or portion thereof with animated graphical user interface
US10888321B2 (en) 2017-06-20 2021-01-12 Ethicon Llc Systems and methods for controlling velocity of a displacement member of a surgical stapling and cutting instrument
USD907648S1 (en) 2017-09-29 2021-01-12 Ethicon Llc Display screen or portion thereof with animated graphical user interface
US10893867B2 (en) 2013-03-14 2021-01-19 Ethicon Llc Drive train control arrangements for modular surgical instruments
US10903685B2 (en) 2017-06-28 2021-01-26 Ethicon Llc Surgical shaft assemblies with slip ring assemblies forming capacitive channels
US10898183B2 (en) 2017-06-29 2021-01-26 Ethicon Llc Robotic surgical instrument with closed loop feedback techniques for advancement of closure member during firing
US10905423B2 (en) 2014-09-05 2021-02-02 Ethicon Llc Smart cartridge wake up operation and data retention
US10905418B2 (en) 2014-10-16 2021-02-02 Ethicon Llc Staple cartridge comprising a tissue thickness compensator
US10912559B2 (en) 2018-08-20 2021-02-09 Ethicon Llc Reinforced deformable anvil tip for surgical stapler anvil
USD910847S1 (en) 2017-12-19 2021-02-16 Ethicon Llc Surgical instrument assembly
US10918380B2 (en) 2006-01-31 2021-02-16 Ethicon Llc Surgical instrument system including a control system
US10932772B2 (en) 2017-06-29 2021-03-02 Ethicon Llc Methods for closed loop velocity control for robotic surgical instrument
US10932778B2 (en) 2008-10-10 2021-03-02 Ethicon Llc Powered surgical cutting and stapling apparatus with manually retractable firing system
US10945728B2 (en) 2014-12-18 2021-03-16 Ethicon Llc Locking arrangements for detachable shaft assemblies with articulatable surgical end effectors
US10945731B2 (en) 2010-09-30 2021-03-16 Ethicon Llc Tissue thickness compensator comprising controlled release and expansion
US10959725B2 (en) 2012-06-15 2021-03-30 Ethicon Llc Articulatable surgical instrument comprising a firing drive
USD914878S1 (en) 2018-08-20 2021-03-30 Ethicon Llc Surgical instrument anvil
US10966718B2 (en) 2017-12-15 2021-04-06 Ethicon Llc Dynamic clamping assemblies with improved wear characteristics for use in connection with electromechanical surgical instruments
US10980539B2 (en) 2015-09-30 2021-04-20 Ethicon Llc Implantable adjunct comprising bonded layers
US10980537B2 (en) 2017-06-20 2021-04-20 Ethicon Llc Closed loop feedback control of motor velocity of a surgical stapling and cutting instrument based on measured time over a specified number of shaft rotations
USD917500S1 (en) 2017-09-29 2021-04-27 Ethicon Llc Display screen or portion thereof with graphical user interface
US10987102B2 (en) 2010-09-30 2021-04-27 Ethicon Llc Tissue thickness compensator comprising a plurality of layers
US10993716B2 (en) 2017-06-27 2021-05-04 Ethicon Llc Surgical anvil arrangements
US11007004B2 (en) 2012-06-28 2021-05-18 Ethicon Llc Powered multi-axial articulable electrosurgical device with external dissection features
US11007022B2 (en) 2017-06-29 2021-05-18 Ethicon Llc Closed loop velocity control techniques based on sensed tissue parameters for robotic surgical instrument
US11006955B2 (en) 2017-12-15 2021-05-18 Ethicon Llc End effectors with positive jaw opening features for use with adapters for electromechanical surgical instruments
US11013511B2 (en) 2007-06-22 2021-05-25 Ethicon Llc Surgical stapling instrument with an articulatable end effector
US11020112B2 (en) 2017-12-19 2021-06-01 Ethicon Llc Surgical tools configured for interchangeable use with different controller interfaces
US11020115B2 (en) 2014-02-12 2021-06-01 Cilag Gmbh International Deliverable surgical instrument
US11026678B2 (en) 2015-09-23 2021-06-08 Cilag Gmbh International Surgical stapler having motor control based on an electrical parameter related to a motor current
US11033267B2 (en) 2017-12-15 2021-06-15 Ethicon Llc Systems and methods of controlling a clamping member firing rate of a surgical instrument
US11039836B2 (en) 2007-01-11 2021-06-22 Cilag Gmbh International Staple cartridge for use with a surgical stapling instrument
US11039834B2 (en) 2018-08-20 2021-06-22 Cilag Gmbh International Surgical stapler anvils with staple directing protrusions and tissue stability features
US11045270B2 (en) 2017-12-19 2021-06-29 Cilag Gmbh International Robotic attachment comprising exterior drive actuator
US11045192B2 (en) 2018-08-20 2021-06-29 Cilag Gmbh International Fabricating techniques for surgical stapler anvils
US11051807B2 (en) 2019-06-28 2021-07-06 Cilag Gmbh International Packaging assembly including a particulate trap
US11052175B2 (en) 2015-08-19 2021-07-06 Musculoskeletal Transplant Foundation Cartilage-derived implants and methods of making and using same
US11051813B2 (en) 2006-01-31 2021-07-06 Cilag Gmbh International Powered surgical instruments with firing system lockout arrangements
US11071545B2 (en) 2014-09-05 2021-07-27 Cilag Gmbh International Smart cartridge wake up operation and data retention
US11071543B2 (en) 2017-12-15 2021-07-27 Cilag Gmbh International Surgical end effectors with clamping assemblies configured to increase jaw aperture ranges
US11071554B2 (en) 2017-06-20 2021-07-27 Cilag Gmbh International Closed loop feedback control of motor velocity of a surgical stapling and cutting instrument based on magnitude of velocity error measurements
US11076853B2 (en) 2017-12-21 2021-08-03 Cilag Gmbh International Systems and methods of displaying a knife position during transection for a surgical instrument
US11083458B2 (en) 2018-08-20 2021-08-10 Cilag Gmbh International Powered surgical instruments with clutching arrangements to convert linear drive motions to rotary drive motions
US11083453B2 (en) 2014-12-18 2021-08-10 Cilag Gmbh International Surgical stapling system including a flexible firing actuator and lateral buckling supports
US11083452B2 (en) 2010-09-30 2021-08-10 Cilag Gmbh International Staple cartridge including a tissue thickness compensator
US11090046B2 (en) 2017-06-20 2021-08-17 Cilag Gmbh International Systems and methods for controlling displacement member motion of a surgical stapling and cutting instrument
US11090075B2 (en) 2017-10-30 2021-08-17 Cilag Gmbh International Articulation features for surgical end effector
US11109859B2 (en) 2015-03-06 2021-09-07 Cilag Gmbh International Surgical instrument comprising a lockable battery housing
US11133106B2 (en) 2013-08-23 2021-09-28 Cilag Gmbh International Surgical instrument assembly comprising a retraction assembly
US11129615B2 (en) 2009-02-05 2021-09-28 Cilag Gmbh International Surgical stapling system
US11129680B2 (en) 2017-12-21 2021-09-28 Cilag Gmbh International Surgical instrument comprising a projector
US11129613B2 (en) 2015-12-30 2021-09-28 Cilag Gmbh International Surgical instruments with separable motors and motor control circuits
US11134944B2 (en) 2017-10-30 2021-10-05 Cilag Gmbh International Surgical stapler knife motion controls
US11134942B2 (en) 2016-12-21 2021-10-05 Cilag Gmbh International Surgical stapling instruments and staple-forming anvils
US11141153B2 (en) 2014-10-29 2021-10-12 Cilag Gmbh International Staple cartridges comprising driver arrangements
US11147551B2 (en) 2019-03-25 2021-10-19 Cilag Gmbh International Firing drive arrangements for surgical systems
US11147553B2 (en) 2019-03-25 2021-10-19 Cilag Gmbh International Firing drive arrangements for surgical systems
US11154301B2 (en) 2015-02-27 2021-10-26 Cilag Gmbh International Modular stapling assembly
US11172929B2 (en) 2019-03-25 2021-11-16 Cilag Gmbh International Articulation drive arrangements for surgical systems
US11179150B2 (en) 2016-04-15 2021-11-23 Cilag Gmbh International Systems and methods for controlling a surgical stapling and cutting instrument
US11197670B2 (en) 2017-12-15 2021-12-14 Cilag Gmbh International Surgical end effectors with pivotal jaws configured to touch at their respective distal ends when fully closed
US11197671B2 (en) 2012-06-28 2021-12-14 Cilag Gmbh International Stapling assembly comprising a lockout
US11202633B2 (en) 2014-09-26 2021-12-21 Cilag Gmbh International Surgical stapling buttresses and adjunct materials
US11207065B2 (en) 2018-08-20 2021-12-28 Cilag Gmbh International Method for fabricating surgical stapler anvils
US11207064B2 (en) 2011-05-27 2021-12-28 Cilag Gmbh International Automated end effector component reloading system for use with a robotic system
US11213293B2 (en) 2016-02-09 2022-01-04 Cilag Gmbh International Articulatable surgical instruments with single articulation link arrangements
US11219455B2 (en) 2019-06-28 2022-01-11 Cilag Gmbh International Surgical instrument including a lockout key
US11224426B2 (en) 2016-02-12 2022-01-18 Cilag Gmbh International Mechanisms for compensating for drivetrain failure in powered surgical instruments
US11224427B2 (en) 2006-01-31 2022-01-18 Cilag Gmbh International Surgical stapling system including a console and retraction assembly
US11224497B2 (en) 2019-06-28 2022-01-18 Cilag Gmbh International Surgical systems with multiple RFID tags
US11224428B2 (en) 2016-12-21 2022-01-18 Cilag Gmbh International Surgical stapling systems
US11224423B2 (en) 2015-03-06 2022-01-18 Cilag Gmbh International Smart sensors with local signal processing
US11229437B2 (en) 2019-06-28 2022-01-25 Cilag Gmbh International Method for authenticating the compatibility of a staple cartridge with a surgical instrument
US11229725B2 (en) 2013-03-15 2022-01-25 Allosource Cell repopulated collagen matrix for soft tissue repair and regeneration
US11234698B2 (en) 2019-12-19 2022-02-01 Cilag Gmbh International Stapling system comprising a clamp lockout and a firing lockout
US11241230B2 (en) 2012-06-28 2022-02-08 Cilag Gmbh International Clip applier tool for use with a robotic surgical system
US11246590B2 (en) 2005-08-31 2022-02-15 Cilag Gmbh International Staple cartridge including staple drivers having different unfired heights
US11246678B2 (en) 2019-06-28 2022-02-15 Cilag Gmbh International Surgical stapling system having a frangible RFID tag
US11246592B2 (en) 2017-06-28 2022-02-15 Cilag Gmbh International Surgical instrument comprising an articulation system lockable to a frame
US11253256B2 (en) 2018-08-20 2022-02-22 Cilag Gmbh International Articulatable motor powered surgical instruments with dedicated articulation motor arrangements
US11253254B2 (en) 2019-04-30 2022-02-22 Cilag Gmbh International Shaft rotation actuator on a surgical instrument
US11259805B2 (en) 2017-06-28 2022-03-01 Cilag Gmbh International Surgical instrument comprising firing member supports
US11259799B2 (en) 2014-03-26 2022-03-01 Cilag Gmbh International Interface systems for use with surgical instruments
US11259803B2 (en) 2019-06-28 2022-03-01 Cilag Gmbh International Surgical stapling system having an information encryption protocol
US11266405B2 (en) 2017-06-27 2022-03-08 Cilag Gmbh International Surgical anvil manufacturing methods
US11266409B2 (en) 2014-04-16 2022-03-08 Cilag Gmbh International Fastener cartridge comprising a sled including longitudinally-staggered ramps
US11272927B2 (en) 2008-02-15 2022-03-15 Cilag Gmbh International Layer arrangements for surgical staple cartridges
US11278279B2 (en) 2006-01-31 2022-03-22 Cilag Gmbh International Surgical instrument assembly
US11284898B2 (en) 2014-09-18 2022-03-29 Cilag Gmbh International Surgical instrument including a deployable knife
US11291449B2 (en) 2009-12-24 2022-04-05 Cilag Gmbh International Surgical cutting instrument that analyzes tissue thickness
US11291440B2 (en) 2018-08-20 2022-04-05 Cilag Gmbh International Method for operating a powered articulatable surgical instrument
US11291441B2 (en) 2007-01-10 2022-04-05 Cilag Gmbh International Surgical instrument with wireless communication between control unit and remote sensor
US11291447B2 (en) 2019-12-19 2022-04-05 Cilag Gmbh International Stapling instrument comprising independent jaw closing and staple firing systems
US11291451B2 (en) 2019-06-28 2022-04-05 Cilag Gmbh International Surgical instrument with battery compatibility verification functionality
US11298132B2 (en) 2019-06-28 2022-04-12 Cilag GmbH Inlernational Staple cartridge including a honeycomb extension
US11298127B2 (en) 2019-06-28 2022-04-12 Cilag GmbH Interational Surgical stapling system having a lockout mechanism for an incompatible cartridge
US11298125B2 (en) 2010-09-30 2022-04-12 Cilag Gmbh International Tissue stapler having a thickness compensator
US11304696B2 (en) 2019-12-19 2022-04-19 Cilag Gmbh International Surgical instrument comprising a powered articulation system
US11304695B2 (en) 2017-08-03 2022-04-19 Cilag Gmbh International Surgical system shaft interconnection
US11311290B2 (en) 2017-12-21 2022-04-26 Cilag Gmbh International Surgical instrument comprising an end effector dampener
US11311294B2 (en) 2014-09-05 2022-04-26 Cilag Gmbh International Powered medical device including measurement of closure state of jaws
US11317913B2 (en) 2016-12-21 2022-05-03 Cilag Gmbh International Lockout arrangements for surgical end effectors and replaceable tool assemblies
US11317917B2 (en) 2016-04-18 2022-05-03 Cilag Gmbh International Surgical stapling system comprising a lockable firing assembly
US11324501B2 (en) 2018-08-20 2022-05-10 Cilag Gmbh International Surgical stapling devices with improved closure members
US11324503B2 (en) 2017-06-27 2022-05-10 Cilag Gmbh International Surgical firing member arrangements
US11344303B2 (en) 2016-02-12 2022-05-31 Cilag Gmbh International Mechanisms for compensating for drivetrain failure in powered surgical instruments
US11350928B2 (en) 2016-04-18 2022-06-07 Cilag Gmbh International Surgical instrument comprising a tissue thickness lockout and speed control system
US11376098B2 (en) 2019-06-28 2022-07-05 Cilag Gmbh International Surgical instrument system comprising an RFID system
US11382638B2 (en) 2017-06-20 2022-07-12 Cilag Gmbh International Closed loop feedback control of motor velocity of a surgical stapling and cutting instrument based on measured time over a specified displacement distance
US11382627B2 (en) 2014-04-16 2022-07-12 Cilag Gmbh International Surgical stapling assembly comprising a firing member including a lateral extension
US11399829B2 (en) 2017-09-29 2022-08-02 Cilag Gmbh International Systems and methods of initiating a power shutdown mode for a surgical instrument
US11399837B2 (en) 2019-06-28 2022-08-02 Cilag Gmbh International Mechanisms for motor control adjustments of a motorized surgical instrument
US11419606B2 (en) 2016-12-21 2022-08-23 Cilag Gmbh International Shaft assembly comprising a clutch configured to adapt the output of a rotary firing member to two different systems
US11426251B2 (en) 2019-04-30 2022-08-30 Cilag Gmbh International Articulation directional lights on a surgical instrument
US11426167B2 (en) 2019-06-28 2022-08-30 Cilag Gmbh International Mechanisms for proper anvil attachment surgical stapling head assembly
US11432816B2 (en) 2019-04-30 2022-09-06 Cilag Gmbh International Articulation pin for a surgical instrument
US11439470B2 (en) 2011-05-27 2022-09-13 Cilag Gmbh International Robotically-controlled surgical instrument with selectively articulatable end effector
US11446029B2 (en) 2019-12-19 2022-09-20 Cilag Gmbh International Staple cartridge comprising projections extending from a curved deck surface
US11452528B2 (en) 2019-04-30 2022-09-27 Cilag Gmbh International Articulation actuators for a surgical instrument
US11452796B2 (en) 2017-06-30 2022-09-27 Allosource Cellular bone grafts, and methods of manufacture and use
US11452526B2 (en) 2020-10-29 2022-09-27 Cilag Gmbh International Surgical instrument comprising a staged voltage regulation start-up system
US11457918B2 (en) 2014-10-29 2022-10-04 Cilag Gmbh International Cartridge assemblies for surgical staplers
US11464601B2 (en) 2019-06-28 2022-10-11 Cilag Gmbh International Surgical instrument comprising an RFID system for tracking a movable component
USD966512S1 (en) 2020-06-02 2022-10-11 Cilag Gmbh International Staple cartridge
US11464512B2 (en) 2019-12-19 2022-10-11 Cilag Gmbh International Staple cartridge comprising a curved deck surface
US11464513B2 (en) 2012-06-28 2022-10-11 Cilag Gmbh International Surgical instrument system including replaceable end effectors
USD967421S1 (en) 2020-06-02 2022-10-18 Cilag Gmbh International Staple cartridge
US11471155B2 (en) 2017-08-03 2022-10-18 Cilag Gmbh International Surgical system bailout
US11471157B2 (en) 2019-04-30 2022-10-18 Cilag Gmbh International Articulation control mapping for a surgical instrument
US11478247B2 (en) 2010-07-30 2022-10-25 Cilag Gmbh International Tissue acquisition arrangements and methods for surgical stapling devices
US11478241B2 (en) 2019-06-28 2022-10-25 Cilag Gmbh International Staple cartridge including projections
US11484312B2 (en) 2005-08-31 2022-11-01 Cilag Gmbh International Staple cartridge comprising a staple driver arrangement
US11497488B2 (en) 2014-03-26 2022-11-15 Cilag Gmbh International Systems and methods for controlling a segmented circuit
US11497492B2 (en) 2019-06-28 2022-11-15 Cilag Gmbh International Surgical instrument including an articulation lock
US11504122B2 (en) 2019-12-19 2022-11-22 Cilag Gmbh International Surgical instrument comprising a nested firing member
US11504116B2 (en) 2011-04-29 2022-11-22 Cilag Gmbh International Layer of material for a surgical end effector
US11517325B2 (en) 2017-06-20 2022-12-06 Cilag Gmbh International Closed loop feedback control of motor velocity of a surgical stapling and cutting instrument based on measured displacement distance traveled over a specified time interval
US11517390B2 (en) 2020-10-29 2022-12-06 Cilag Gmbh International Surgical instrument comprising a limited travel switch
US11523821B2 (en) 2014-09-26 2022-12-13 Cilag Gmbh International Method for creating a flexible staple line
US11523822B2 (en) 2019-06-28 2022-12-13 Cilag Gmbh International Battery pack including a circuit interrupter
US11523823B2 (en) 2016-02-09 2022-12-13 Cilag Gmbh International Surgical instruments with non-symmetrical articulation arrangements
US11529139B2 (en) 2019-12-19 2022-12-20 Cilag Gmbh International Motor driven surgical instrument
US11529137B2 (en) 2019-12-19 2022-12-20 Cilag Gmbh International Staple cartridge comprising driver retention members
US11534259B2 (en) 2020-10-29 2022-12-27 Cilag Gmbh International Surgical instrument comprising an articulation indicator
USD974560S1 (en) 2020-06-02 2023-01-03 Cilag Gmbh International Staple cartridge
USD975278S1 (en) 2020-06-02 2023-01-10 Cilag Gmbh International Staple cartridge
US11553971B2 (en) 2019-06-28 2023-01-17 Cilag Gmbh International Surgical RFID assemblies for display and communication
USD975850S1 (en) 2020-06-02 2023-01-17 Cilag Gmbh International Staple cartridge
USD975851S1 (en) 2020-06-02 2023-01-17 Cilag Gmbh International Staple cartridge
USD976401S1 (en) 2020-06-02 2023-01-24 Cilag Gmbh International Staple cartridge
US11559304B2 (en) 2019-12-19 2023-01-24 Cilag Gmbh International Surgical instrument comprising a rapid closure mechanism
US11564686B2 (en) 2017-06-28 2023-01-31 Cilag Gmbh International Surgical shaft assemblies with flexible interfaces
US11564682B2 (en) 2007-06-04 2023-01-31 Cilag Gmbh International Surgical stapler device
US11571215B2 (en) 2010-09-30 2023-02-07 Cilag Gmbh International Layer of material for a surgical end effector
US11576672B2 (en) 2019-12-19 2023-02-14 Cilag Gmbh International Surgical instrument comprising a closure system including a closure member and an opening member driven by a drive screw
USD980425S1 (en) 2020-10-29 2023-03-07 Cilag Gmbh International Surgical instrument assembly
US11607219B2 (en) 2019-12-19 2023-03-21 Cilag Gmbh International Staple cartridge comprising a detachable tissue cutting knife
US11607239B2 (en) 2016-04-15 2023-03-21 Cilag Gmbh International Systems and methods for controlling a surgical stapling and cutting instrument
US11617577B2 (en) 2020-10-29 2023-04-04 Cilag Gmbh International Surgical instrument comprising a sensor configured to sense whether an articulation drive of the surgical instrument is actuatable
US11622763B2 (en) 2013-04-16 2023-04-11 Cilag Gmbh International Stapling assembly comprising a shiftable drive
US11622766B2 (en) 2012-06-28 2023-04-11 Cilag Gmbh International Empty clip cartridge lockout
US11627960B2 (en) 2020-12-02 2023-04-18 Cilag Gmbh International Powered surgical instruments with smart reload with separately attachable exteriorly mounted wiring connections
US11627959B2 (en) 2019-06-28 2023-04-18 Cilag Gmbh International Surgical instruments including manual and powered system lockouts
US11638582B2 (en) 2020-07-28 2023-05-02 Cilag Gmbh International Surgical instruments with torsion spine drive arrangements
US11638587B2 (en) 2019-06-28 2023-05-02 Cilag Gmbh International RFID identification systems for surgical instruments
US11648009B2 (en) 2019-04-30 2023-05-16 Cilag Gmbh International Rotatable jaw tip for a surgical instrument
US11648005B2 (en) 2008-09-23 2023-05-16 Cilag Gmbh International Robotically-controlled motorized surgical instrument with an end effector
US11653914B2 (en) 2017-06-20 2023-05-23 Cilag Gmbh International Systems and methods for controlling motor velocity of a surgical stapling and cutting instrument according to articulation angle of end effector
US11653915B2 (en) 2020-12-02 2023-05-23 Cilag Gmbh International Surgical instruments with sled location detection and adjustment features
US11653920B2 (en) 2020-12-02 2023-05-23 Cilag Gmbh International Powered surgical instruments with communication interfaces through sterile barrier
US11660163B2 (en) 2019-06-28 2023-05-30 Cilag Gmbh International Surgical system with RFID tags for updating motor assembly parameters
US11678877B2 (en) 2014-12-18 2023-06-20 Cilag Gmbh International Surgical instrument including a flexible support configured to support a flexible firing member
US11678882B2 (en) 2020-12-02 2023-06-20 Cilag Gmbh International Surgical instruments with interactive features to remedy incidental sled movements
US11684434B2 (en) 2019-06-28 2023-06-27 Cilag Gmbh International Surgical RFID assemblies for instrument operational setting control
US11696761B2 (en) 2019-03-25 2023-07-11 Cilag Gmbh International Firing drive arrangements for surgical systems
US11696757B2 (en) 2021-02-26 2023-07-11 Cilag Gmbh International Monitoring of internal systems to detect and track cartridge motion status
US11701113B2 (en) 2021-02-26 2023-07-18 Cilag Gmbh International Stapling instrument comprising a separate power antenna and a data transfer antenna
US11701111B2 (en) 2019-12-19 2023-07-18 Cilag Gmbh International Method for operating a surgical stapling instrument
US11717289B2 (en) 2020-10-29 2023-08-08 Cilag Gmbh International Surgical instrument comprising an indicator which indicates that an articulation drive is actuatable
US11717291B2 (en) 2021-03-22 2023-08-08 Cilag Gmbh International Staple cartridge comprising staples configured to apply different tissue compression
US11717294B2 (en) 2014-04-16 2023-08-08 Cilag Gmbh International End effector arrangements comprising indicators
US11723658B2 (en) 2021-03-22 2023-08-15 Cilag Gmbh International Staple cartridge comprising a firing lockout
US11723657B2 (en) 2021-02-26 2023-08-15 Cilag Gmbh International Adjustable communication based on available bandwidth and power capacity
US11723662B2 (en) 2021-05-28 2023-08-15 Cilag Gmbh International Stapling instrument comprising an articulation control display
US11730473B2 (en) 2021-02-26 2023-08-22 Cilag Gmbh International Monitoring of manufacturing life-cycle
US11737751B2 (en) 2020-12-02 2023-08-29 Cilag Gmbh International Devices and methods of managing energy dissipated within sterile barriers of surgical instrument housings
US11737749B2 (en) 2021-03-22 2023-08-29 Cilag Gmbh International Surgical stapling instrument comprising a retraction system
US11744581B2 (en) 2020-12-02 2023-09-05 Cilag Gmbh International Powered surgical instruments with multi-phase tissue treatment
US11744603B2 (en) 2021-03-24 2023-09-05 Cilag Gmbh International Multi-axis pivot joints for surgical instruments and methods for manufacturing same
US11744583B2 (en) 2021-02-26 2023-09-05 Cilag Gmbh International Distal communication array to tune frequency of RF systems
US11749877B2 (en) 2021-02-26 2023-09-05 Cilag Gmbh International Stapling instrument comprising a signal antenna
US11751869B2 (en) 2021-02-26 2023-09-12 Cilag Gmbh International Monitoring of multiple sensors over time to detect moving characteristics of tissue
US11759202B2 (en) 2021-03-22 2023-09-19 Cilag Gmbh International Staple cartridge comprising an implantable layer
US11766260B2 (en) 2016-12-21 2023-09-26 Cilag Gmbh International Methods of stapling tissue
US11766259B2 (en) 2016-12-21 2023-09-26 Cilag Gmbh International Method of deforming staples from two different types of staple cartridges with the same surgical stapling instrument
US11771419B2 (en) 2019-06-28 2023-10-03 Cilag Gmbh International Packaging for a replaceable component of a surgical stapling system
US11779330B2 (en) 2020-10-29 2023-10-10 Cilag Gmbh International Surgical instrument comprising a jaw alignment system
US11786243B2 (en) 2021-03-24 2023-10-17 Cilag Gmbh International Firing members having flexible portions for adapting to a load during a surgical firing stroke
US11786239B2 (en) 2021-03-24 2023-10-17 Cilag Gmbh International Surgical instrument articulation joint arrangements comprising multiple moving linkage features
US11793518B2 (en) 2006-01-31 2023-10-24 Cilag Gmbh International Powered surgical instruments with firing system lockout arrangements
US11793516B2 (en) 2021-03-24 2023-10-24 Cilag Gmbh International Surgical staple cartridge comprising longitudinal support beam
US11793514B2 (en) 2021-02-26 2023-10-24 Cilag Gmbh International Staple cartridge comprising sensor array which may be embedded in cartridge body
US11793522B2 (en) 2015-09-30 2023-10-24 Cilag Gmbh International Staple cartridge assembly including a compressible adjunct
US11806011B2 (en) 2021-03-22 2023-11-07 Cilag Gmbh International Stapling instrument comprising tissue compression systems
US11812964B2 (en) 2021-02-26 2023-11-14 Cilag Gmbh International Staple cartridge comprising a power management circuit
US11826012B2 (en) 2021-03-22 2023-11-28 Cilag Gmbh International Stapling instrument comprising a pulsed motor-driven firing rack
US11826042B2 (en) 2021-03-22 2023-11-28 Cilag Gmbh International Surgical instrument comprising a firing drive including a selectable leverage mechanism
US11826132B2 (en) 2015-03-06 2023-11-28 Cilag Gmbh International Time dependent evaluation of sensor data to determine stability, creep, and viscoelastic elements of measures
US11826048B2 (en) 2017-06-28 2023-11-28 Cilag Gmbh International Surgical instrument comprising selectively actuatable rotatable couplers
US11832816B2 (en) 2021-03-24 2023-12-05 Cilag Gmbh International Surgical stapling assembly comprising nonplanar staples and planar staples
US11839352B2 (en) 2007-01-11 2023-12-12 Cilag Gmbh International Surgical stapling device with an end effector
US11844518B2 (en) 2020-10-29 2023-12-19 Cilag Gmbh International Method for operating a surgical instrument
US11844520B2 (en) 2019-12-19 2023-12-19 Cilag Gmbh International Staple cartridge comprising driver retention members
US11849944B2 (en) 2021-03-24 2023-12-26 Cilag Gmbh International Drivers for fastener cartridge assemblies having rotary drive screws
US11849945B2 (en) 2021-03-24 2023-12-26 Cilag Gmbh International Rotary-driven surgical stapling assembly comprising eccentrically driven firing member
US11849941B2 (en) 2007-06-29 2023-12-26 Cilag Gmbh International Staple cartridge having staple cavities extending at a transverse angle relative to a longitudinal cartridge axis
US11849943B2 (en) 2020-12-02 2023-12-26 Cilag Gmbh International Surgical instrument with cartridge release mechanisms
US11849952B2 (en) 2010-09-30 2023-12-26 Cilag Gmbh International Staple cartridge comprising staples positioned within a compressible portion thereof
US11857183B2 (en) 2021-03-24 2024-01-02 Cilag Gmbh International Stapling assembly components having metal substrates and plastic bodies
US11877745B2 (en) 2021-10-18 2024-01-23 Cilag Gmbh International Surgical stapling assembly having longitudinally-repeating staple leg clusters
US11883026B2 (en) 2014-04-16 2024-01-30 Cilag Gmbh International Fastener cartridge assemblies and staple retainer cover arrangements
USD1013170S1 (en) 2020-10-29 2024-01-30 Cilag Gmbh International Surgical instrument assembly
US11890010B2 (en) 2020-12-02 2024-02-06 Cllag GmbH International Dual-sided reinforced reload for surgical instruments
US11890012B2 (en) 2004-07-28 2024-02-06 Cilag Gmbh International Staple cartridge comprising cartridge body and attached support
US11896218B2 (en) 2021-03-24 2024-02-13 Cilag Gmbh International Method of using a powered stapling device
US11896217B2 (en) 2020-10-29 2024-02-13 Cilag Gmbh International Surgical instrument comprising an articulation lock
US11896219B2 (en) 2021-03-24 2024-02-13 Cilag Gmbh International Mating features between drivers and underside of a cartridge deck
US11903582B2 (en) 2021-03-24 2024-02-20 Cilag Gmbh International Leveraging surfaces for cartridge installation
US11903581B2 (en) 2019-04-30 2024-02-20 Cilag Gmbh International Methods for stapling tissue using a surgical instrument
US11911032B2 (en) 2019-12-19 2024-02-27 Cilag Gmbh International Staple cartridge comprising a seating cam
US11925349B2 (en) 2021-02-26 2024-03-12 Cilag Gmbh International Adjustment to transfer parameters to improve available power
US11931033B2 (en) 2019-12-19 2024-03-19 Cilag Gmbh International Staple cartridge comprising a latch lockout

Families Citing this family (46)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6638312B2 (en) * 2000-08-04 2003-10-28 Depuy Orthopaedics, Inc. Reinforced small intestinal submucosa (SIS)
US8366787B2 (en) * 2000-08-04 2013-02-05 Depuy Products, Inc. Hybrid biologic-synthetic bioabsorbable scaffolds
WO2003007839A2 (en) * 2001-07-16 2003-01-30 Depuy Products, Inc. Devices form naturally occurring biologically derived
AU2002316696B2 (en) * 2001-07-16 2007-08-30 Depuy Products, Inc. Cartilage repair and regeneration scaffold and method
US7819918B2 (en) * 2001-07-16 2010-10-26 Depuy Products, Inc. Implantable tissue repair device
EP1416888A4 (en) 2001-07-16 2007-04-25 Depuy Products Inc Meniscus regeneration device and method
US20050027307A1 (en) * 2001-07-16 2005-02-03 Schwartz Herbert Eugene Unitary surgical device and method
US8025896B2 (en) 2001-07-16 2011-09-27 Depuy Products, Inc. Porous extracellular matrix scaffold and method
WO2003007790A2 (en) 2001-07-16 2003-01-30 Depuy Products, Inc. Hybrid biologic/synthetic porous extracellular matrix scaffolds
US20040166169A1 (en) * 2002-07-15 2004-08-26 Prasanna Malaviya Porous extracellular matrix scaffold and method
US7550004B2 (en) 2002-08-20 2009-06-23 Cook Biotech Incorporated Endoluminal device with extracellular matrix material and methods
GB0307011D0 (en) * 2003-03-27 2003-04-30 Regentec Ltd Porous matrix
US7794408B2 (en) * 2003-03-28 2010-09-14 Ethicon, Inc. Tissue collection device and methods
US20050064042A1 (en) * 2003-04-29 2005-03-24 Musculoskeletal Transplant Foundation Cartilage implant plug with fibrin glue and method for implantation
US20050222687A1 (en) * 2004-04-02 2005-10-06 Gordana Vunjak-Novakovic Cartilage implant assembly and method for implantation
US7067123B2 (en) * 2003-04-29 2006-06-27 Musculoskeletal Transplant Foundation Glue for cartilage repair
US7901457B2 (en) 2003-05-16 2011-03-08 Musculoskeletal Transplant Foundation Cartilage allograft plug
US7488348B2 (en) * 2003-05-16 2009-02-10 Musculoskeletal Transplant Foundation Cartilage allograft plug
US6974862B2 (en) * 2003-06-20 2005-12-13 Kensey Nash Corporation High density fibrous polymers suitable for implant
US8034003B2 (en) 2003-09-11 2011-10-11 Depuy Mitek, Inc. Tissue extraction and collection device
US7611473B2 (en) * 2003-09-11 2009-11-03 Ethicon, Inc. Tissue extraction and maceration device
US8657881B2 (en) * 2004-04-20 2014-02-25 Depuy Mitek, Llc Meniscal repair scaffold
US20050249772A1 (en) * 2004-05-04 2005-11-10 Prasanna Malaviya Hybrid biologic-synthetic bioabsorbable scaffolds
US7569233B2 (en) * 2004-05-04 2009-08-04 Depuy Products, Inc. Hybrid biologic-synthetic bioabsorbable scaffolds
US7837740B2 (en) * 2007-01-24 2010-11-23 Musculoskeletal Transplant Foundation Two piece cancellous construct for cartilage repair
EP1652473A1 (en) 2004-10-29 2006-05-03 DePuy Products, Inc. Implant system with sizing templates
DE602005001827T2 (en) * 2004-10-29 2008-04-24 Depuy Products, Inc., Warsaw Instruments and kits for the suture assembly system
US7513866B2 (en) * 2004-10-29 2009-04-07 Depuy Products, Inc. Intestine processing device and associated method
US7354627B2 (en) * 2004-12-22 2008-04-08 Depuy Products, Inc. Method for organizing the assembly of collagen fibers and compositions formed therefrom
US7815926B2 (en) 2005-07-11 2010-10-19 Musculoskeletal Transplant Foundation Implant for articular cartilage repair
WO2007035778A2 (en) 2005-09-19 2007-03-29 Histogenics Corporation Cell-support matrix and a method for preparation thereof
CN100369590C (en) * 2005-09-19 2008-02-20 西安交通大学 Process for manufacturing wind-up type liver tissue engineering stent
KR100715505B1 (en) 2006-01-07 2007-05-08 민병현 Method for preparing a cell-derived extracellular matrix scaffold
KR100816395B1 (en) * 2006-09-21 2008-03-27 (주)필미아젠 Method for preparing a cell-derived extracellular matrix membrane
US7871440B2 (en) * 2006-12-11 2011-01-18 Depuy Products, Inc. Unitary surgical device and method
US8435551B2 (en) 2007-03-06 2013-05-07 Musculoskeletal Transplant Foundation Cancellous construct with support ring for repair of osteochondral defects
EP2121062B1 (en) * 2007-03-07 2020-05-06 Coloplast A/S Fistula plug comprising ecm
US20100136645A1 (en) * 2007-04-17 2010-06-03 Byoung-Hyun Min Method for preparing a cell-derived extracellular matrix scaffold
US20100119577A1 (en) * 2007-05-06 2010-05-13 Byoung-Hyun Min Therapeutic composite for cartilage disorder using extracellular matrix (ecm) scaffold
CA2708147A1 (en) * 2007-12-05 2009-06-18 Musculoskeletal Transplant Foundation Cancellous bone implant for cartilage repair
WO2009111069A1 (en) 2008-03-05 2009-09-11 Musculoskeletal Transplant Foundation Cancellous constructs, cartilage particles and combinations of cancellous constructs and cartilage particles
WO2010065843A2 (en) * 2008-12-05 2010-06-10 University Of Pittsburgh-Of The Commonwealth System Of Higher Education Biologic scaffold for prevention of pulmonary fibrosis
AU2012262311B2 (en) * 2011-05-31 2016-04-28 Lifecell Corporation Adipose tissue matrices
US10077420B2 (en) 2014-12-02 2018-09-18 Histogenics Corporation Cell and tissue culture container
US10363036B2 (en) 2015-09-23 2019-07-30 Ethicon Llc Surgical stapler having force-based motor control
AU2020218555A1 (en) 2019-02-07 2021-09-16 Biorez, Inc. Composite scaffold for the repair, reconstruction, and regeneration of soft tissues

Citations (245)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB606427A (en) 1944-03-20 1948-08-13 American Cyanamid Co Improvements relating to collagenous strands and method of making the same
GB805843A (en) 1956-03-20 1958-12-17 Ohio Commw Eng Co Collagen strands and method of treating
GB968840A (en) 1960-05-02 1964-09-02 Armour & Co Improvements in and relating to colagen fibre materials
US3272204A (en) 1965-09-22 1966-09-13 Ethicon Inc Absorbable collagen prosthetic implant with non-absorbable reinforcing strands
US3562820A (en) 1966-08-22 1971-02-16 Bernhard Braun Tubular sheet and strip form prostheses on a basis of biological tissue
US4105034A (en) 1977-06-10 1978-08-08 Ethicon, Inc. Poly(alkylene oxalate) absorbable coating for sutures
US4130639A (en) 1977-09-28 1978-12-19 Ethicon, Inc. Absorbable pharmaceutical compositions based on isomorphic copolyoxalates
US4140678A (en) 1977-06-13 1979-02-20 Ethicon, Inc. Synthetic absorbable surgical devices of poly(alkylene oxalates)
US4141087A (en) 1977-01-19 1979-02-27 Ethicon, Inc. Isomorphic copolyoxalates and sutures thereof
FR2422386A1 (en) 1978-04-13 1979-11-09 Christian Buscayret Device for fastening suture into tissue - has rectangular body with two perforations accommodating suture and two protuberances engaging tissue
US4205399A (en) 1977-06-13 1980-06-03 Ethicon, Inc. Synthetic absorbable surgical devices of poly(alkylene oxalates)
US4208511A (en) 1977-01-19 1980-06-17 Ethicon, Inc. Isomorphic copolyoxalates and sutures thereof
US4352463A (en) 1979-01-18 1982-10-05 Leisure Lawn, Inc. Motorized combination wet and dry lawn treatment spreader
US4400833A (en) 1981-06-10 1983-08-30 Kurland Kenneth Z Means and method of implanting bioprosthetics
US4418691A (en) 1981-10-26 1983-12-06 Massachusetts Institute Of Technology Method of promoting the regeneration of tissue at a wound
US4585458A (en) 1981-06-10 1986-04-29 Kurland Kenneth Z Means and method of implanting bioprosthetics
US4610397A (en) * 1983-10-27 1986-09-09 Urschel Laboratories Incorporated Comminuting equipment
US4642120A (en) 1983-03-23 1987-02-10 Ramot University Authority For Applied Research And Industrial Development Ltd. Repair of cartilage and bones
US4669473A (en) 1985-09-06 1987-06-02 Acufex Microsurgical, Inc. Surgical fastener
US4703108A (en) * 1984-03-27 1987-10-27 University Of Medicine & Dentistry Of New Jersey Biodegradable matrix and methods for producing same
US4705040A (en) 1985-11-18 1987-11-10 Medi-Tech, Incorporated Percutaneous fixation of hollow organs
US4741330A (en) 1983-05-19 1988-05-03 Hayhurst John O Method and apparatus for anchoring and manipulating cartilage
US4750492A (en) 1985-02-27 1988-06-14 Richards Medical Company Absorbable suture apparatus, method and installer
US4846835A (en) 1987-06-15 1989-07-11 Grande Daniel A Technique for healing lesions in cartilage
US4873976A (en) 1984-02-28 1989-10-17 Schreiber Saul N Surgical fasteners and method
US4880429A (en) 1987-07-20 1989-11-14 Stone Kevin R Prosthetic meniscus
US4902508A (en) 1988-07-11 1990-02-20 Purdue Research Foundation Tissue graft composition
US4919667A (en) 1988-12-02 1990-04-24 Stryker Corporation Implant
US4956179A (en) 1971-11-01 1990-09-11 Astra Lakemedel Aktiebolag Antibacterial combination of penicillin and cephalosporin
US4956178A (en) 1988-07-11 1990-09-11 Purdue Research Foundation Tissue graft composition
US4976715A (en) 1986-05-20 1990-12-11 Concept, Inc. Repair tack for bodily tissue
US5007934A (en) 1987-07-20 1991-04-16 Regen Corporation Prosthetic meniscus
EP0446105A2 (en) 1990-03-06 1991-09-11 Showa Shell Sekiyu Kabushiki Kaisha Water absorptive and retentive flexible cloth and method for producing same
US5061286A (en) 1989-08-18 1991-10-29 Osteotech, Inc. Osteoprosthetic implant
US5102421A (en) 1990-06-14 1992-04-07 Wm. E. Anpach, III Suture anchor and method of forming
US5108438A (en) 1989-03-02 1992-04-28 Regen Corporation Prosthetic intervertebral disc
US5128326A (en) 1984-12-06 1992-07-07 Biomatrix, Inc. Drug delivery systems based on hyaluronans derivatives thereof and their salts and methods of producing same
USRE34021E (en) 1985-11-18 1992-08-04 Abbott Laboratories Percutaneous fixation of hollow organs
GB2215209B (en) 1988-03-14 1992-08-26 Osmed Inc Method and apparatus for biodegradable, osteogenic, bone graft substitute device
US5236431A (en) 1991-07-22 1993-08-17 Synthes Resorbable fixation device with controlled stiffness for treating bodily material in vivo and introducer therefor
US5246441A (en) 1989-09-08 1993-09-21 Linvatec Corporation Bioabsorbable tack for joining bodily tissue
US5258015A (en) 1991-05-03 1993-11-02 American Cyanamid Company Locking filament caps
US5269809A (en) 1990-07-02 1993-12-14 American Cyanamid Company Locking mechanism for use with a slotted suture anchor
US5275826A (en) 1992-11-13 1994-01-04 Purdue Research Foundation Fluidized intestinal submucosa and its use as an injectable tissue graft
US5281422A (en) 1991-09-24 1994-01-25 Purdue Research Foundation Graft for promoting autogenous tissue growth
EP0591991A2 (en) 1992-10-09 1994-04-13 United States Surgical Corporation Suture loop locking device
US5306311A (en) 1987-07-20 1994-04-26 Regen Corporation Prosthetic articular cartilage
US5320633A (en) 1992-12-10 1994-06-14 William C. Allen Method and system for repairing a tear in the meniscus
US5329846A (en) 1991-08-12 1994-07-19 Bonutti Peter M Tissue press and system
US5350583A (en) 1988-03-09 1994-09-27 Terumo Kabushiki Kaisha Cell-penetrable medical material and artificial skin
US5352463A (en) 1992-11-13 1994-10-04 Badylak Steven F Tissue graft for surgical reconstruction of a collagenous meniscus and method therefor
US5374268A (en) 1991-05-13 1994-12-20 United States Surgical Corporation Device and method for repairing torn tissue
US5376118A (en) 1989-05-10 1994-12-27 United States Surgical Corporation Support material for cell impregnation
US5380334A (en) 1993-02-17 1995-01-10 Smith & Nephew Dyonics, Inc. Soft tissue anchors and systems for implantation
EP0632999A1 (en) 1993-07-01 1995-01-11 United States Surgical Corporation Soft tissue repair system and method
US5447940A (en) 1993-07-28 1995-09-05 Johnson & Johnson Medical, Inc. Absorbable composite materials for use in the treatment of periodontal disease
US5460962A (en) 1994-01-04 1995-10-24 Organogenesis Inc. Peracetic acid sterilization of collagen or collagenous tissue
US5464929A (en) 1995-03-06 1995-11-07 Ethicon, Inc. Absorbable polyoxaesters
US5479033A (en) 1994-05-27 1995-12-26 Sandia Corporation Complementary junction heterostructure field-effect transistor
US5514181A (en) 1993-09-29 1996-05-07 Johnson & Johnson Medical, Inc. Absorbable structures for ligament and tendon repair
US5520691A (en) 1990-11-06 1996-05-28 Branch; Thomas P. Method and apparatus for re-approximating tissue
US5545178A (en) 1994-04-29 1996-08-13 Kensey Nash Corporation System for closing a percutaneous puncture formed by a trocar to prevent tissue at the puncture from herniating
US5554389A (en) 1995-04-07 1996-09-10 Purdue Research Foundation Urinary bladder submucosa derived tissue graft
EP0734736A1 (en) 1995-03-31 1996-10-02 Toyo Boseki Kabushiki Kaisha Medical device and method for producing the same
US5569252A (en) 1994-09-27 1996-10-29 Justin; Daniel F. Device for repairing a meniscal tear in a knee and method
US5591234A (en) 1993-02-01 1997-01-07 Axel Kirsch Post-surgery orthopedic covering
US5593441A (en) 1992-03-04 1997-01-14 C. R. Bard, Inc. Method for limiting the incidence of postoperative adhesions
US5595751A (en) 1995-03-06 1997-01-21 Ethicon, Inc. Absorbable polyoxaesters containing amines and/or amido groups
US5597579A (en) 1995-03-06 1997-01-28 Ethicon, Inc. Blends of absorbable polyoxaamides
US5607687A (en) 1995-03-06 1997-03-04 Ethicon, Inc. Polymer blends containing absorbable polyoxaesters
US5618552A (en) 1995-03-06 1997-04-08 Ethicon, Inc. Absorbable polyoxaesters
US5620698A (en) 1995-03-06 1997-04-15 Ethicon, Inc. Blends of absorbable polyoxaesters containing amines and/or amido groups
US5626614A (en) 1995-12-22 1997-05-06 Applied Medical Resources Corporation T-anchor suturing device and method for using same
US5630824A (en) 1994-06-01 1997-05-20 Innovasive Devices, Inc. Suture attachment device
US5632745A (en) 1995-02-07 1997-05-27 R&D Biologicals, Inc. Surgical implantation of cartilage repair unit
US5641518A (en) 1992-11-13 1997-06-24 Purdue Research Foundation Method of repairing bone tissue
US5645860A (en) 1995-04-07 1997-07-08 Purdue Research Foundation Tissue graft and method for urinary urothelium reconstruction replacement
US5660225A (en) 1993-08-30 1997-08-26 Saffran; Bruce Nathan Method of fracture treatment by restraining macromolecules or macromolecular aggregates adjacent to damaged tissues
US5668288A (en) 1996-04-16 1997-09-16 Depuy Orthopaedics, Inc. Polyester ionomers for implant fabrication
US5669912A (en) 1994-04-26 1997-09-23 Spetzler; Robert F. Apparatus for securing a cranial piece in position
US5677355A (en) 1993-08-13 1997-10-14 Smith & Nephew, Inc. Continuous open-cell polymeric foams containing living cells
US5681353A (en) 1987-07-20 1997-10-28 Regen Biologics, Inc. Meniscal augmentation device
US5693085A (en) 1994-04-29 1997-12-02 Scimed Life Systems, Inc. Stent with collagen
US5695998A (en) 1995-02-10 1997-12-09 Purdue Research Foundation Submucosa as a growth substrate for islet cells
US5698213A (en) 1995-03-06 1997-12-16 Ethicon, Inc. Hydrogels of absorbable polyoxaesters
US5700583A (en) 1995-03-06 1997-12-23 Ethicon, Inc. Hydrogels of absorbable polyoxaesters containing amines or amido groups
US5702462A (en) 1996-01-24 1997-12-30 Oberlander; Michael Method of meniscal repair
US5711969A (en) * 1995-04-07 1998-01-27 Purdue Research Foundation Large area submucosal tissue graft constructs
US5711960A (en) 1993-09-24 1998-01-27 Takiron Co., Ltd. Biocompatible implant material comprising a tri-axial or more three-dimensional fabric
US5725556A (en) 1995-12-15 1998-03-10 M & R Medical, Inc. Suture locking apparatus
US5730933A (en) 1996-04-16 1998-03-24 Depuy Orthopaedics, Inc. Radiation sterilization of biologically active compounds
US5733337A (en) 1995-04-07 1998-03-31 Organogenesis, Inc. Tissue repair fabric
US5733868A (en) 1996-04-16 1998-03-31 Depuy Orthopaedics, Inc. Poly(amino acid) adhesive tissue grafts
US5736372A (en) 1986-11-20 1998-04-07 Massachusetts Institute Of Technology Biodegradable synthetic polymeric fibrous matrix containing chondrocyte for in vivo production of a cartilaginous structure
US5735897A (en) 1993-10-19 1998-04-07 Scimed Life Systems, Inc. Intravascular stent pump
US5755791A (en) 1996-04-05 1998-05-26 Purdue Research Foundation Perforated submucosal tissue graft constructs
WO1998022158A2 (en) 1996-08-23 1998-05-28 Cook Biotech, Incorporated Graft prosthesis, materials and methods
US5759205A (en) 1994-01-21 1998-06-02 Brown University Research Foundation Negatively charged polymeric electret implant
US5759190A (en) 1996-08-30 1998-06-02 Vts Holdings Limited Method and kit for autologous transplantation
US5762600A (en) 1994-04-29 1998-06-09 W. L. Gore & Associates, Inc. Blood contact surfaces employing natural subendothelial matrix and methods for making and using the same
US5769899A (en) 1994-08-12 1998-06-23 Matrix Biotechnologies, Inc. Cartilage repair unit
US5773577A (en) 1994-03-03 1998-06-30 Protein Polymer Technologies Products comprising substrates capable of enzymatic cross-linking
US5788625A (en) 1996-04-05 1998-08-04 Depuy Orthopaedics, Inc. Method of making reconstructive SIS structure for cartilaginous elements in situ
US5795353A (en) 1994-05-06 1998-08-18 Advanced Bio Surfaces, Inc. Joint resurfacing system
US5800537A (en) 1992-08-07 1998-09-01 Tissue Engineering, Inc. Method and construct for producing graft tissue from an extracellular matrix
US5830708A (en) 1995-06-06 1998-11-03 Advanced Tissue Sciences, Inc. Methods for production of a naturally secreted extracellular matrix
US5834232A (en) 1996-05-01 1998-11-10 Zymogenetics, Inc. Cross-linked gelatin gels and methods of making them
US5842477A (en) 1996-02-21 1998-12-01 Advanced Tissue Sciences, Inc. Method for repairing cartilage
US5855610A (en) 1995-05-19 1999-01-05 Children's Medical Center Corporation Engineering of strong, pliable tissues
US5855619A (en) 1994-06-06 1999-01-05 Case Western Reserve University Biomatrix for soft tissue regeneration
US5855613A (en) 1995-10-13 1999-01-05 Islet Sheet Medical, Inc. Retrievable bioartificial implants having dimensions allowing rapid diffusion of oxygen and rapid biological response to physiological change
US5859150A (en) 1995-03-06 1999-01-12 Ethicon, Inc. Prepolymers of absorbable polyoxaesters
US5861004A (en) 1991-11-08 1999-01-19 Kensey Nash Corporation Hemostatic puncture closure system including closure locking means and method of use
US5863551A (en) 1996-10-16 1999-01-26 Organogel Canada Ltee Implantable polymer hydrogel for therapeutic uses
US5866165A (en) 1997-01-15 1999-02-02 Orquest, Inc. Collagen-polysaccharide matrix for bone and cartilage repair
US5891558A (en) 1994-11-22 1999-04-06 Tissue Engineering, Inc. Biopolymer foams for use in tissue repair and reconstruction
US5899939A (en) 1998-01-21 1999-05-04 Osteotech, Inc. Bone-derived implant for load-supporting applications
US5906997A (en) 1997-06-17 1999-05-25 Fzio Med, Inc. Bioresorbable compositions of carboxypolysaccharide polyether intermacromolecular complexes and methods for their use in reducing surgical adhesions
US5916265A (en) 1994-03-30 1999-06-29 Hu; Jie Method of producing a biological extracellular matrix for use as a cell seeding scaffold and implant
US5939323A (en) 1996-05-28 1999-08-17 Brown University Hyaluronan based biodegradable scaffolds for tissue repair
US5948429A (en) 1994-11-22 1999-09-07 Tissue Engineering, Inc. Methods for preparing biopolymer foams
US5955100A (en) 1992-10-27 1999-09-21 Behringwerke Aktiengesellschaft Prodrugs their preparation and use as pharmaceuticals
US5954747A (en) 1997-11-20 1999-09-21 Clark; Ron Meniscus repair anchor system
US5954723A (en) 1994-04-26 1999-09-21 Spetzler; Robert F. Method and apparatus for securing a cranial plate with pins
US5958874A (en) 1998-02-18 1999-09-28 The Research Foundation Of State University Of New York Recombinant fibronectin-based extracellular matrix for wound healing
US5971987A (en) 1998-09-18 1999-10-26 Ethicon, Inc. Biocompatible absorbable polymer fastener and driver for use in surgical procedures
US5980524A (en) 1997-06-02 1999-11-09 Innovasive Devices, Inc. Device for repairing a meniscal tear in a knee and method
US5981802A (en) 1995-12-14 1999-11-09 The Trustees Of Columbia University In The City Of New York Simple allylic amination procedure
US5981825A (en) 1994-05-13 1999-11-09 Thm Biomedical, Inc. Device and methods for in vivo culturing of diverse tissue cells
US5989269A (en) 1996-08-30 1999-11-23 Vts Holdings L.L.C. Method, instruments and kit for autologous transplantation
US5989280A (en) 1993-10-22 1999-11-23 Scimed Lifesystems, Inc Stent delivery apparatus and method
JPH11319068A (en) 1998-05-12 1999-11-24 Menicon Co Ltd Base material for artificial skin and production thereof
US5993844A (en) 1997-05-08 1999-11-30 Organogenesis, Inc. Chemical treatment, without detergents or enzymes, of tissue to form an acellular, collagenous matrix
US5993475A (en) 1998-04-22 1999-11-30 Bristol-Myers Squibb Co. Tissue repair device
US6010525A (en) 1997-08-01 2000-01-04 Peter M. Bonutti Method and apparatus for securing a suture
US6017348A (en) 1995-03-07 2000-01-25 Innovasive Devices, Inc. Apparatus and methods for articular cartilage defect repair
US6027744A (en) 1998-04-24 2000-02-22 University Of Massachusetts Medical Center Guided development and support of hydrogel-cell compositions
US6056778A (en) 1997-10-29 2000-05-02 Arthrex, Inc. Meniscal repair device
US6056777A (en) 1998-02-27 2000-05-02 Mcdowell; Charles L. Method and device for regenerating cartilage in articulating
US6056752A (en) 1997-10-24 2000-05-02 Smith & Nephew, Inc. Fixation of cruciate ligament grafts
WO2000024437A2 (en) 1998-10-28 2000-05-04 Ashby Scientific Ltd. Textured and porous silicone rubber
US6060640A (en) 1995-05-19 2000-05-09 Baxter International Inc. Multiple-layer, formed-in-place immunoisolation membrane structures for implantation of cells in host tissue
US6066160A (en) 1998-11-23 2000-05-23 Quickie Llc Passive knotless suture terminator for use in minimally invasive surgery and to facilitate standard tissue securing
US6068648A (en) 1998-01-26 2000-05-30 Orthodyne, Inc. Tissue anchoring system and method
US6077989A (en) 1996-05-28 2000-06-20 Kandel; Rita Resorbable implant biomaterial made of condensed calcium phosphate particles
US6080194A (en) 1995-02-10 2000-06-27 The Hospital For Joint Disease Orthopaedic Institute Multi-stage collagen-based template or implant for use in the repair of cartilage lesions
US6093201A (en) 1999-01-19 2000-07-25 Ethicon, Inc. Biocompatible absorbable polymer plating system for tissue fixation
US6098347A (en) 1998-01-21 2000-08-08 Jaeger; Leroy L. Metal framed geodesic structure
US6099567A (en) 1996-12-10 2000-08-08 Purdue Research Foundation Stomach submucosa derived tissue graft
US6110212A (en) 1994-11-15 2000-08-29 Kenton W. Gregory Elastin and elastin-based materials
US6126686A (en) 1996-12-10 2000-10-03 Purdue Research Foundation Artificial vascular valves
US6146385A (en) 1997-02-11 2000-11-14 Smith & Nephew, Inc. Repairing cartilage
US6152935A (en) 1996-12-11 2000-11-28 Ethicon, Inc. Meniscal repair device having integral spring member
US6171344B1 (en) 1996-08-16 2001-01-09 Children's Medical Center Corporation Bladder submucosa seeded with cells for tissue reconstruction
US6179872B1 (en) 1998-03-17 2001-01-30 Tissue Engineering Biopolymer matt for use in tissue repair and reconstruction
US6179840B1 (en) 1999-07-23 2001-01-30 Ethicon, Inc. Graft fixation device and method
US6187039B1 (en) 1996-12-10 2001-02-13 Purdue Research Foundation Tubular submucosal graft constructs
US6197296B1 (en) 1993-03-29 2001-03-06 National Heart Research Fund Tissue equivalents
US6214047B1 (en) 1998-03-10 2001-04-10 University Of Cincinnati Article and method for coupling muscle to a prosthetic device
US6214048B1 (en) 1992-02-10 2001-04-10 Matsumoto Dental College Bone substitute product and method of producing the same
US6214049B1 (en) 1999-01-14 2001-04-10 Comfort Biomedical, Inc. Method and apparatus for augmentating osteointegration of prosthetic implant devices
US6224892B1 (en) 1997-03-01 2001-05-01 Smith & Nephew Plc Polyesterhydrogels
US6235057B1 (en) 1995-01-24 2001-05-22 Smith & Nephew, Inc. Method for soft tissue reconstruction
US6242247B1 (en) 1996-06-04 2001-06-05 Sulzer Orthopedics Ltd. Method for making cartilage and implants
WO2001039694A2 (en) 1999-12-03 2001-06-07 University Of Leeds Repair of damaged tissue
US6251876B1 (en) 1996-06-21 2001-06-26 Fidia, S.P.A. Autocross-linked hyaluronic acid and related pharmaceutical compositions for the treatment of arthropathies
US6251143B1 (en) 1999-06-04 2001-06-26 Depuy Orthopaedics, Inc. Cartilage repair unit
US6264702B1 (en) 1997-08-01 2001-07-24 Sofradim Production Composite prosthesis for preventing post-surgical adhesions
US6265333B1 (en) 1998-06-02 2001-07-24 Board Of Regents, University Of Nebraska-Lincoln Delamination resistant composites prepared by small diameter fiber reinforcement at ply interfaces
US6267957B1 (en) 1998-01-20 2001-07-31 Howard Green Attaching agents to tissue with transglutaminase and a transglutaminase substrate
US6270530B1 (en) 1997-05-01 2001-08-07 C.R. Bard, Inc. Prosthetic repair fabric
US6273893B1 (en) 1999-11-10 2001-08-14 Ethicon, Inc. Absorbable rivet/pin applier for use in surgical procedures
US6280474B1 (en) 1997-01-09 2001-08-28 Neucoll, Inc. Devices for tissue repair and methods for preparation and use thereof
US6280473B1 (en) 1996-08-19 2001-08-28 Macropore, Inc. Resorbable, macro-porous, non-collapsing and flexible membrane barrier for skeletal repair and regeneration
US6288043B1 (en) 1999-06-18 2001-09-11 Orquest, Inc. Injectable hyaluronate-sulfated polysaccharide conjugates
US6290711B1 (en) 1999-08-13 2001-09-18 Innovasive Devices, Inc. Connector device and method for surgically joining and securing flexible tissue repair members
US6294041B1 (en) 1998-02-06 2001-09-25 Osteotech, Inc. Method for an osteoimplant manufacture
US6293961B2 (en) 1998-12-30 2001-09-25 Ethicon, Inc. Suture locking device
WO2001070293A1 (en) 2000-03-18 2001-09-27 The University Of Nottingham Polymeric composite materials and their manufacture
US20010024658A1 (en) 1999-08-17 2001-09-27 Feng-Jing Chen Pharmaceutical dosage form for oral administration of hydrophilic drugs, particularly low molecular weight heparin
US6299905B1 (en) 1996-04-16 2001-10-09 Depuy Orthopaedics, Inc. Bioerodable polymeric adhesives for tissue repair
US6306159B1 (en) 1998-12-23 2001-10-23 Depuy Orthopaedics, Inc. Meniscal repair device
US6306177B1 (en) 1994-05-06 2001-10-23 Advanced Bio Surfaces, Inc. Biomaterial system for in situ tissue repair
US6319258B1 (en) 1999-09-29 2001-11-20 Ethicon, Inc. Absorbable rivet/pin applier for use in surgical procedures
US20010043943A1 (en) 2000-05-22 2001-11-22 Coffey Arthur C. Combination SIS and vacuum bandage and method
US6326025B1 (en) 1998-12-30 2001-12-04 Depuy Orthopaedics, Inc Tissue reactive adhesive compositions
US6333029B1 (en) 1999-06-30 2001-12-25 Ethicon, Inc. Porous tissue scaffoldings for the repair of regeneration of tissue
US6334872B1 (en) 1994-02-18 2002-01-01 Organogenesis Inc. Method for treating diseased or damaged organs
US20020019649A1 (en) 1999-12-02 2002-02-14 Smith & Nephew, Inc., Delaware Corporation Closure device and method for tissue repair
US6355699B1 (en) 1999-06-30 2002-03-12 Ethicon, Inc. Process for manufacturing biomedical foams
US20020038151A1 (en) 2000-08-04 2002-03-28 Plouhar Pamela L. Reinforced small intestinal submucosa (SIS)
US6364884B1 (en) 1999-07-23 2002-04-02 Ethicon, Inc. Method of securing a graft using a graft fixation device
US6371958B1 (en) 2000-03-02 2002-04-16 Ethicon, Inc. Scaffold fixation device for use in articular cartilage repair
US6373221B2 (en) 1999-12-27 2002-04-16 Kabushiki Kaisha Toyoda Jidoshokki Seisakusho Charger coupling
US20020048595A1 (en) 1995-02-22 2002-04-25 Peter Geistlich Resorbable extracellular matrix for reconstruction of cartilage tissue
US6379710B1 (en) 1996-12-10 2002-04-30 Purdue Research Foundation Biomaterial derived from vertebrate liver tissue
US20020052628A1 (en) 1999-07-23 2002-05-02 Bowman Steven M. Graft fixation device and method
US6383221B1 (en) 1999-01-22 2002-05-07 Osteotech, Inc. Method for forming an intervertebral implant
US6409764B1 (en) 1998-12-03 2002-06-25 Charles F. White Methods and articles for regenerating bone or peridontal tissue
US20020090725A1 (en) 2000-11-17 2002-07-11 Simpson David G. Electroprocessed collagen
US20020091444A1 (en) 2001-01-05 2002-07-11 Jun Yang Vascular tissue composition
US20020095157A1 (en) 1999-07-23 2002-07-18 Bowman Steven M. Graft fixation device combination
US6423073B2 (en) 1999-07-23 2002-07-23 Ethicon, Inc. Instrument for inserting graft fixation device
US20020099448A1 (en) 1996-08-23 2002-07-25 Michael C. Hiles Multi-formed collagenous biomaterial medical device
US6436110B2 (en) 1999-07-23 2002-08-20 Ethicon, Inc. Method of securing a graft using a graft fixation device
US6440444B2 (en) 1999-02-23 2002-08-27 Osteotech, Inc. Load bearing osteoimplant and method of repairing bone using the same
US6447517B1 (en) 1999-07-23 2002-09-10 Ethicon, Inc. Instrument for inserting graft fixation device
US6451032B1 (en) 1997-08-01 2002-09-17 Sofradim Production Composite prosthesis for preventing post-surgical adhesions and method for obtaining same
US20020131989A1 (en) 2000-12-22 2002-09-19 Brown Kelly R. Implantable biodegradable devices for musculoskeletal repair or regeneration
US6458158B1 (en) 1999-01-05 2002-10-01 Lifenet Composite bone graft, method of making and using same
US6464729B1 (en) 1995-11-06 2002-10-15 Mount Sinai Hospital Corporation Reconstituted mineralized cartilage tissue
US20020165611A1 (en) 1998-12-22 2002-11-07 Robert-Jan Enzerink Graft material convenience package
US20020169465A1 (en) 1999-07-23 2002-11-14 Bowman Steven M. Graft fixation device
US20020173806A1 (en) 1996-08-30 2002-11-21 Verigen Transplantation Service International (Vtsi) Ag Method for autologous transplantation
US6497650B1 (en) 1999-07-28 2002-12-24 C. R. Bard, Inc. Hernia prosthesis
US6497707B1 (en) 1999-07-23 2002-12-24 Ethicon, Inc. Graft fixation device combination
US20030014126A1 (en) * 2001-06-28 2003-01-16 Patel Umesh H. Graft prosthesis devices containing renal capsule collagen
US6508821B1 (en) 2000-01-28 2003-01-21 Depuy Orthopaedics, Inc. Soft tissue repair material fixation apparatus and method
WO2003007790A2 (en) 2001-07-16 2003-01-30 Depuy Products, Inc. Hybrid biologic/synthetic porous extracellular matrix scaffolds
WO2003007788A2 (en) 2001-07-16 2003-01-30 Depuy Products, Inc. Unitary surgical device and method
US20030023316A1 (en) 2000-08-04 2003-01-30 Brown Laura Jean Hybrid biologic-synthetic bioabsorable scaffolds
US6517564B1 (en) 1999-02-02 2003-02-11 Arthrex, Inc. Bioabsorbable tissue tack with oval-shaped head and method of tissue fixation using same
US20030033021A1 (en) 2001-07-16 2003-02-13 Plouhar Pamela Lynn Cartilage repair and regeneration scaffold and method
US20030032961A1 (en) * 2001-07-16 2003-02-13 Pelo Mark Joseph Devices from naturally occurring biologically derived materials
US20030036801A1 (en) 2001-07-16 2003-02-20 Schwartz Herbert E. Cartilage repair apparatus and method
US20030036797A1 (en) 2001-07-16 2003-02-20 Prasanna Malaviya Meniscus regeneration device and method
US20030044444A1 (en) 2001-07-16 2003-03-06 Prasanna Malaviya Porous extracellular matrix scaffold and method
US20030049299A1 (en) 2001-07-16 2003-03-13 Prasanna Malaviya Porous delivery scaffold and method
US6566345B2 (en) 2000-04-28 2003-05-20 Fziomed, Inc. Polyacid/polyalkylene oxide foams and gels and methods for their delivery
US6572650B1 (en) 1998-06-05 2003-06-03 Organogenesis Inc. Bioengineered vascular graft support prostheses
US6592623B1 (en) 1999-08-31 2003-07-15 Virginia Commonwealth University Intellectual Property Foundation Engineered muscle
US6596296B1 (en) 1999-08-06 2003-07-22 Board Of Regents, The University Of Texas System Drug releasing biodegradable fiber implant
US6652872B2 (en) 1999-07-06 2003-11-25 Ramat At Tel Aviv University Ltd. Scaffold formed of tissue treated to eliminate cellular and cytosolic elements
WO2003097694A1 (en) 2002-05-21 2003-11-27 Colltech Australia Ltd Collagen and method for producing same
US6692499B2 (en) 1997-07-02 2004-02-17 Linvatec Biomaterials Oy Surgical fastener for tissue treatment
US20040143344A1 (en) 2001-07-16 2004-07-22 Prasanna Malaviya Implantable tissue repair device and method
US20040166169A1 (en) 2002-07-15 2004-08-26 Prasanna Malaviya Porous extracellular matrix scaffold and method
US6812221B2 (en) 2000-11-21 2004-11-02 The Texas A&M University System FGF-affinity chromatography
US6840962B1 (en) 1995-05-01 2005-01-11 Massachusetts Institute Of Technology Tissue engineered tendons and ligaments
US6869938B1 (en) 1997-06-17 2005-03-22 Fziomed, Inc. Compositions of polyacids and polyethers and methods for their use in reducing adhesions
EP1593400A1 (en) 2004-05-04 2005-11-09 Depuy Products, Inc. Hybrid biologic-synthetic bioabsorbable scaffolds
US20050249772A1 (en) 2004-05-04 2005-11-10 Prasanna Malaviya Hybrid biologic-synthetic bioabsorbable scaffolds
US20050249771A1 (en) 2004-05-04 2005-11-10 Prasanna Malaviya Hybrid biologic-synthetic bioabsorbable scaffolds
US6989034B2 (en) 2002-05-31 2006-01-24 Ethicon, Inc. Attachment of absorbable tissue scaffolds to fixation devices
US8258124B2 (en) 2002-12-12 2012-09-04 Nycomed Gmbh Combination medicament

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5759208A (en) * 1996-02-29 1998-06-02 The Procter & Gamble Company Laundry detergent compositions containing silicone emulsions
US6258124B1 (en) * 1999-05-10 2001-07-10 C. R. Bard, Inc. Prosthetic repair fabric

Patent Citations (297)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB606427A (en) 1944-03-20 1948-08-13 American Cyanamid Co Improvements relating to collagenous strands and method of making the same
GB805843A (en) 1956-03-20 1958-12-17 Ohio Commw Eng Co Collagen strands and method of treating
GB968840A (en) 1960-05-02 1964-09-02 Armour & Co Improvements in and relating to colagen fibre materials
US3272204A (en) 1965-09-22 1966-09-13 Ethicon Inc Absorbable collagen prosthetic implant with non-absorbable reinforcing strands
US3562820A (en) 1966-08-22 1971-02-16 Bernhard Braun Tubular sheet and strip form prostheses on a basis of biological tissue
US4956179A (en) 1971-11-01 1990-09-11 Astra Lakemedel Aktiebolag Antibacterial combination of penicillin and cephalosporin
US4141087A (en) 1977-01-19 1979-02-27 Ethicon, Inc. Isomorphic copolyoxalates and sutures thereof
US4208511A (en) 1977-01-19 1980-06-17 Ethicon, Inc. Isomorphic copolyoxalates and sutures thereof
US4105034A (en) 1977-06-10 1978-08-08 Ethicon, Inc. Poly(alkylene oxalate) absorbable coating for sutures
US4140678A (en) 1977-06-13 1979-02-20 Ethicon, Inc. Synthetic absorbable surgical devices of poly(alkylene oxalates)
US4205399A (en) 1977-06-13 1980-06-03 Ethicon, Inc. Synthetic absorbable surgical devices of poly(alkylene oxalates)
US4130639A (en) 1977-09-28 1978-12-19 Ethicon, Inc. Absorbable pharmaceutical compositions based on isomorphic copolyoxalates
FR2422386A1 (en) 1978-04-13 1979-11-09 Christian Buscayret Device for fastening suture into tissue - has rectangular body with two perforations accommodating suture and two protuberances engaging tissue
US4352463A (en) 1979-01-18 1982-10-05 Leisure Lawn, Inc. Motorized combination wet and dry lawn treatment spreader
US4400833A (en) 1981-06-10 1983-08-30 Kurland Kenneth Z Means and method of implanting bioprosthetics
US4585458A (en) 1981-06-10 1986-04-29 Kurland Kenneth Z Means and method of implanting bioprosthetics
US4418691A (en) 1981-10-26 1983-12-06 Massachusetts Institute Of Technology Method of promoting the regeneration of tissue at a wound
US4642120A (en) 1983-03-23 1987-02-10 Ramot University Authority For Applied Research And Industrial Development Ltd. Repair of cartilage and bones
US4741330A (en) 1983-05-19 1988-05-03 Hayhurst John O Method and apparatus for anchoring and manipulating cartilage
US4610397A (en) * 1983-10-27 1986-09-09 Urschel Laboratories Incorporated Comminuting equipment
US4873976A (en) 1984-02-28 1989-10-17 Schreiber Saul N Surgical fasteners and method
US4703108A (en) * 1984-03-27 1987-10-27 University Of Medicine & Dentistry Of New Jersey Biodegradable matrix and methods for producing same
US5128326A (en) 1984-12-06 1992-07-07 Biomatrix, Inc. Drug delivery systems based on hyaluronans derivatives thereof and their salts and methods of producing same
US4750492A (en) 1985-02-27 1988-06-14 Richards Medical Company Absorbable suture apparatus, method and installer
US4669473A (en) 1985-09-06 1987-06-02 Acufex Microsurgical, Inc. Surgical fastener
US4705040A (en) 1985-11-18 1987-11-10 Medi-Tech, Incorporated Percutaneous fixation of hollow organs
USRE34021E (en) 1985-11-18 1992-08-04 Abbott Laboratories Percutaneous fixation of hollow organs
US4976715A (en) 1986-05-20 1990-12-11 Concept, Inc. Repair tack for bodily tissue
US5736372A (en) 1986-11-20 1998-04-07 Massachusetts Institute Of Technology Biodegradable synthetic polymeric fibrous matrix containing chondrocyte for in vivo production of a cartilaginous structure
US4846835A (en) 1987-06-15 1989-07-11 Grande Daniel A Technique for healing lesions in cartilage
US5007934A (en) 1987-07-20 1991-04-16 Regen Corporation Prosthetic meniscus
US5681353A (en) 1987-07-20 1997-10-28 Regen Biologics, Inc. Meniscal augmentation device
US6042610A (en) 1987-07-20 2000-03-28 Regen Biologics, Inc. Meniscal augmentation device
US4880429A (en) 1987-07-20 1989-11-14 Stone Kevin R Prosthetic meniscus
US5306311A (en) 1987-07-20 1994-04-26 Regen Corporation Prosthetic articular cartilage
US5735903A (en) 1987-07-20 1998-04-07 Li; Shu-Tung Meniscal augmentation device
US5350583A (en) 1988-03-09 1994-09-27 Terumo Kabushiki Kaisha Cell-penetrable medical material and artificial skin
GB2215209B (en) 1988-03-14 1992-08-26 Osmed Inc Method and apparatus for biodegradable, osteogenic, bone graft substitute device
US4956178A (en) 1988-07-11 1990-09-11 Purdue Research Foundation Tissue graft composition
US4902508A (en) 1988-07-11 1990-02-20 Purdue Research Foundation Tissue graft composition
US4919667A (en) 1988-12-02 1990-04-24 Stryker Corporation Implant
US5108438A (en) 1989-03-02 1992-04-28 Regen Corporation Prosthetic intervertebral disc
US5376118A (en) 1989-05-10 1994-12-27 United States Surgical Corporation Support material for cell impregnation
US5061286A (en) 1989-08-18 1991-10-29 Osteotech, Inc. Osteoprosthetic implant
US5246441A (en) 1989-09-08 1993-09-21 Linvatec Corporation Bioabsorbable tack for joining bodily tissue
EP0446105A2 (en) 1990-03-06 1991-09-11 Showa Shell Sekiyu Kabushiki Kaisha Water absorptive and retentive flexible cloth and method for producing same
US5102421A (en) 1990-06-14 1992-04-07 Wm. E. Anpach, III Suture anchor and method of forming
US5269809A (en) 1990-07-02 1993-12-14 American Cyanamid Company Locking mechanism for use with a slotted suture anchor
US5520691A (en) 1990-11-06 1996-05-28 Branch; Thomas P. Method and apparatus for re-approximating tissue
US5258015A (en) 1991-05-03 1993-11-02 American Cyanamid Company Locking filament caps
US5374268A (en) 1991-05-13 1994-12-20 United States Surgical Corporation Device and method for repairing torn tissue
US5236431A (en) 1991-07-22 1993-08-17 Synthes Resorbable fixation device with controlled stiffness for treating bodily material in vivo and introducer therefor
US5329846A (en) 1991-08-12 1994-07-19 Bonutti Peter M Tissue press and system
US5445833A (en) 1991-09-24 1995-08-29 Purdue Research Foundation Tendon or ligament graft for promoting autogenous tissue growth
US5372821A (en) 1991-09-24 1994-12-13 Purdue Research Foundation Graft for promoting autogenous tissue growth
US5573784A (en) 1991-09-24 1996-11-12 Purdue Research Foundation Graft for promoting autogenous tissue growth
US5281422A (en) 1991-09-24 1994-01-25 Purdue Research Foundation Graft for promoting autogenous tissue growth
US5861004A (en) 1991-11-08 1999-01-19 Kensey Nash Corporation Hemostatic puncture closure system including closure locking means and method of use
US6214048B1 (en) 1992-02-10 2001-04-10 Matsumoto Dental College Bone substitute product and method of producing the same
US5593441A (en) 1992-03-04 1997-01-14 C. R. Bard, Inc. Method for limiting the incidence of postoperative adhesions
US5800537A (en) 1992-08-07 1998-09-01 Tissue Engineering, Inc. Method and construct for producing graft tissue from an extracellular matrix
US6051750A (en) 1992-08-07 2000-04-18 Tissue Engineering, Inc. Method and construct for producing graft tissue from an extracellular matrix
EP0591991A2 (en) 1992-10-09 1994-04-13 United States Surgical Corporation Suture loop locking device
US5955100A (en) 1992-10-27 1999-09-21 Behringwerke Aktiengesellschaft Prodrugs their preparation and use as pharmaceuticals
US5641518A (en) 1992-11-13 1997-06-24 Purdue Research Foundation Method of repairing bone tissue
US5516533A (en) 1992-11-13 1996-05-14 Purdue Research Foundation Fluidized intestinal submucosa and its use as an injectable tissue graft
US5352463A (en) 1992-11-13 1994-10-04 Badylak Steven F Tissue graft for surgical reconstruction of a collagenous meniscus and method therefor
US5275826A (en) 1992-11-13 1994-01-04 Purdue Research Foundation Fluidized intestinal submucosa and its use as an injectable tissue graft
US5320633A (en) 1992-12-10 1994-06-14 William C. Allen Method and system for repairing a tear in the meniscus
US5591234A (en) 1993-02-01 1997-01-07 Axel Kirsch Post-surgery orthopedic covering
US5601558A (en) 1993-02-17 1997-02-11 Smith & Nephew Endoscopy, Inc. Soft tissue anchors and systems for implantation
US5380334A (en) 1993-02-17 1995-01-10 Smith & Nephew Dyonics, Inc. Soft tissue anchors and systems for implantation
US6197296B1 (en) 1993-03-29 2001-03-06 National Heart Research Fund Tissue equivalents
EP0632999A1 (en) 1993-07-01 1995-01-11 United States Surgical Corporation Soft tissue repair system and method
US5447940A (en) 1993-07-28 1995-09-05 Johnson & Johnson Medical, Inc. Absorbable composite materials for use in the treatment of periodontal disease
US5969020A (en) 1993-08-13 1999-10-19 Poly-Med, Inc. Microporous polymeric foams and microtextured surfaces
US5677355A (en) 1993-08-13 1997-10-14 Smith & Nephew, Inc. Continuous open-cell polymeric foams containing living cells
US5847012A (en) 1993-08-13 1998-12-08 Smith & Nephew, Inc. Microporous polymeric foams and microtextured surfaces
US5660225A (en) 1993-08-30 1997-08-26 Saffran; Bruce Nathan Method of fracture treatment by restraining macromolecules or macromolecular aggregates adjacent to damaged tissues
US5711960A (en) 1993-09-24 1998-01-27 Takiron Co., Ltd. Biocompatible implant material comprising a tri-axial or more three-dimensional fabric
US5514181A (en) 1993-09-29 1996-05-07 Johnson & Johnson Medical, Inc. Absorbable structures for ligament and tendon repair
US5595621A (en) 1993-09-29 1997-01-21 Johnson & Johnson Medical, Inc. Method of making absorbable structures for ligament and tendon repair
US5735897A (en) 1993-10-19 1998-04-07 Scimed Life Systems, Inc. Intravascular stent pump
US5989280A (en) 1993-10-22 1999-11-23 Scimed Lifesystems, Inc Stent delivery apparatus and method
US20030212447A1 (en) 1993-10-22 2003-11-13 Euteneuer Charles L. Stent delivery apparatus and method
US5460962A (en) 1994-01-04 1995-10-24 Organogenesis Inc. Peracetic acid sterilization of collagen or collagenous tissue
US5759205A (en) 1994-01-21 1998-06-02 Brown University Research Foundation Negatively charged polymeric electret implant
US6334872B1 (en) 1994-02-18 2002-01-01 Organogenesis Inc. Method for treating diseased or damaged organs
US5773577A (en) 1994-03-03 1998-06-30 Protein Polymer Technologies Products comprising substrates capable of enzymatic cross-linking
US5916265A (en) 1994-03-30 1999-06-29 Hu; Jie Method of producing a biological extracellular matrix for use as a cell seeding scaffold and implant
US5669912A (en) 1994-04-26 1997-09-23 Spetzler; Robert F. Apparatus for securing a cranial piece in position
US5954723A (en) 1994-04-26 1999-09-21 Spetzler; Robert F. Method and apparatus for securing a cranial plate with pins
US5545178A (en) 1994-04-29 1996-08-13 Kensey Nash Corporation System for closing a percutaneous puncture formed by a trocar to prevent tissue at the puncture from herniating
US5762600A (en) 1994-04-29 1998-06-09 W. L. Gore & Associates, Inc. Blood contact surfaces employing natural subendothelial matrix and methods for making and using the same
US5693085A (en) 1994-04-29 1997-12-02 Scimed Life Systems, Inc. Stent with collagen
US5795353A (en) 1994-05-06 1998-08-18 Advanced Bio Surfaces, Inc. Joint resurfacing system
US6306177B1 (en) 1994-05-06 2001-10-23 Advanced Bio Surfaces, Inc. Biomaterial system for in situ tissue repair
US5981825A (en) 1994-05-13 1999-11-09 Thm Biomedical, Inc. Device and methods for in vivo culturing of diverse tissue cells
US5479033A (en) 1994-05-27 1995-12-26 Sandia Corporation Complementary junction heterostructure field-effect transistor
US5630824A (en) 1994-06-01 1997-05-20 Innovasive Devices, Inc. Suture attachment device
US5855619A (en) 1994-06-06 1999-01-05 Case Western Reserve University Biomatrix for soft tissue regeneration
US5769899A (en) 1994-08-12 1998-06-23 Matrix Biotechnologies, Inc. Cartilage repair unit
US5569252A (en) 1994-09-27 1996-10-29 Justin; Daniel F. Device for repairing a meniscal tear in a knee and method
US6110212A (en) 1994-11-15 2000-08-29 Kenton W. Gregory Elastin and elastin-based materials
US5891558A (en) 1994-11-22 1999-04-06 Tissue Engineering, Inc. Biopolymer foams for use in tissue repair and reconstruction
US6153292A (en) 1994-11-22 2000-11-28 Tissue Engineering, Inc. Biopolymer foams for use in tissue repair and reconstruction
US5948429A (en) 1994-11-22 1999-09-07 Tissue Engineering, Inc. Methods for preparing biopolymer foams
US6235057B1 (en) 1995-01-24 2001-05-22 Smith & Nephew, Inc. Method for soft tissue reconstruction
US5632745A (en) 1995-02-07 1997-05-27 R&D Biologicals, Inc. Surgical implantation of cartilage repair unit
US5866414A (en) 1995-02-10 1999-02-02 Badylak; Stephen F. Submucosa gel as a growth substrate for cells
US5753267A (en) 1995-02-10 1998-05-19 Purdue Research Foundation Method for enhancing functional properties of submucosal tissue graft constructs
US5695998A (en) 1995-02-10 1997-12-09 Purdue Research Foundation Submucosa as a growth substrate for islet cells
US6080194A (en) 1995-02-10 2000-06-27 The Hospital For Joint Disease Orthopaedic Institute Multi-stage collagen-based template or implant for use in the repair of cartilage lesions
US20020048595A1 (en) 1995-02-22 2002-04-25 Peter Geistlich Resorbable extracellular matrix for reconstruction of cartilage tissue
US5859150A (en) 1995-03-06 1999-01-12 Ethicon, Inc. Prepolymers of absorbable polyoxaesters
US5698213A (en) 1995-03-06 1997-12-16 Ethicon, Inc. Hydrogels of absorbable polyoxaesters
US5618552A (en) 1995-03-06 1997-04-08 Ethicon, Inc. Absorbable polyoxaesters
US5595751A (en) 1995-03-06 1997-01-21 Ethicon, Inc. Absorbable polyoxaesters containing amines and/or amido groups
US5620698A (en) 1995-03-06 1997-04-15 Ethicon, Inc. Blends of absorbable polyoxaesters containing amines and/or amido groups
US5607687A (en) 1995-03-06 1997-03-04 Ethicon, Inc. Polymer blends containing absorbable polyoxaesters
US5464929A (en) 1995-03-06 1995-11-07 Ethicon, Inc. Absorbable polyoxaesters
US5648088A (en) 1995-03-06 1997-07-15 Ethicon, Inc. Blends of absorbable polyoxaesters containing amines and/or amide groups
US5597579A (en) 1995-03-06 1997-01-28 Ethicon, Inc. Blends of absorbable polyoxaamides
US5700583A (en) 1995-03-06 1997-12-23 Ethicon, Inc. Hydrogels of absorbable polyoxaesters containing amines or amido groups
US5645850A (en) 1995-03-06 1997-07-08 Ethicon, Inc. Blending containing absorbable polyoxaamides
US6017348A (en) 1995-03-07 2000-01-25 Innovasive Devices, Inc. Apparatus and methods for articular cartilage defect repair
EP0734736A1 (en) 1995-03-31 1996-10-02 Toyo Boseki Kabushiki Kaisha Medical device and method for producing the same
US5762966A (en) 1995-04-07 1998-06-09 Purdue Research Foundation Tissue graft and method for urinary tract urothelium reconstruction and replacement
US5733337A (en) 1995-04-07 1998-03-31 Organogenesis, Inc. Tissue repair fabric
US5885619A (en) 1995-04-07 1999-03-23 Purdue Research Foundation Large area submucosal tissue graft constructs and method for making the same
US5711969A (en) * 1995-04-07 1998-01-27 Purdue Research Foundation Large area submucosal tissue graft constructs
US5645860A (en) 1995-04-07 1997-07-08 Purdue Research Foundation Tissue graft and method for urinary urothelium reconstruction replacement
US5554389A (en) 1995-04-07 1996-09-10 Purdue Research Foundation Urinary bladder submucosa derived tissue graft
US6840962B1 (en) 1995-05-01 2005-01-11 Massachusetts Institute Of Technology Tissue engineered tendons and ligaments
US5855610A (en) 1995-05-19 1999-01-05 Children's Medical Center Corporation Engineering of strong, pliable tissues
US6060640A (en) 1995-05-19 2000-05-09 Baxter International Inc. Multiple-layer, formed-in-place immunoisolation membrane structures for implantation of cells in host tissue
US5830708A (en) 1995-06-06 1998-11-03 Advanced Tissue Sciences, Inc. Methods for production of a naturally secreted extracellular matrix
US6165225A (en) 1995-10-13 2000-12-26 Islet Sheet Medical Llc Retrievable bioartificial implants having dimensions allowing rapid diffusion of oxygen and rapid biological response to physiological change, processes for their manufacture, and methods for their use
US5855613A (en) 1995-10-13 1999-01-05 Islet Sheet Medical, Inc. Retrievable bioartificial implants having dimensions allowing rapid diffusion of oxygen and rapid biological response to physiological change
US6464729B1 (en) 1995-11-06 2002-10-15 Mount Sinai Hospital Corporation Reconstituted mineralized cartilage tissue
US5981802A (en) 1995-12-14 1999-11-09 The Trustees Of Columbia University In The City Of New York Simple allylic amination procedure
US5725556A (en) 1995-12-15 1998-03-10 M & R Medical, Inc. Suture locking apparatus
US5626614A (en) 1995-12-22 1997-05-06 Applied Medical Resources Corporation T-anchor suturing device and method for using same
US5702462A (en) 1996-01-24 1997-12-30 Oberlander; Michael Method of meniscal repair
US5842477A (en) 1996-02-21 1998-12-01 Advanced Tissue Sciences, Inc. Method for repairing cartilage
US5997575A (en) 1996-04-05 1999-12-07 Purdue Research Foundation Perforated submucosal tissue graft constructs
US20010023373A1 (en) 1996-04-05 2001-09-20 Plouhar Pamela L. Tissue graft construct for replacement of cartilaginous structures
US20010002446A1 (en) 1996-04-05 2001-05-31 Plouhar Pamela L. Tissue graft construct for replacement of cartilaginous structures
US6176880B1 (en) 1996-04-05 2001-01-23 Depuy Orthopaedics, Inc. Tissue graft construct for replacement of cartilaginous structures
US5755791A (en) 1996-04-05 1998-05-26 Purdue Research Foundation Perforated submucosal tissue graft constructs
US5968096A (en) 1996-04-05 1999-10-19 Purdue Research Foundation Method of repairing perforated submucosal tissue graft constructs
US5922028A (en) 1996-04-05 1999-07-13 Depuy Orthopaedics, Inc. Multi-layered SIS tissue graft construct for replacement of cartilaginous elements in situ
US5788625A (en) 1996-04-05 1998-08-04 Depuy Orthopaedics, Inc. Method of making reconstructive SIS structure for cartilaginous elements in situ
US5668288A (en) 1996-04-16 1997-09-16 Depuy Orthopaedics, Inc. Polyester ionomers for implant fabrication
US6299905B1 (en) 1996-04-16 2001-10-09 Depuy Orthopaedics, Inc. Bioerodable polymeric adhesives for tissue repair
US5730933A (en) 1996-04-16 1998-03-24 Depuy Orthopaedics, Inc. Radiation sterilization of biologically active compounds
US5733868A (en) 1996-04-16 1998-03-31 Depuy Orthopaedics, Inc. Poly(amino acid) adhesive tissue grafts
US20020034533A1 (en) 1996-04-16 2002-03-21 Peterson Dale R. Bioerodable polymeric adhesives for tissue repair
US20020031551A1 (en) 1996-04-16 2002-03-14 Peterson Dale R. Bioerodable polymeric adhesives for tissue repair
US5834232A (en) 1996-05-01 1998-11-10 Zymogenetics, Inc. Cross-linked gelatin gels and methods of making them
US6077989A (en) 1996-05-28 2000-06-20 Kandel; Rita Resorbable implant biomaterial made of condensed calcium phosphate particles
US5939323A (en) 1996-05-28 1999-08-17 Brown University Hyaluronan based biodegradable scaffolds for tissue repair
US6242247B1 (en) 1996-06-04 2001-06-05 Sulzer Orthopedics Ltd. Method for making cartilage and implants
US6387693B2 (en) 1996-06-04 2002-05-14 Sulzer Orthopedics Ltd. Method for producing cartilage tissue and implants for repairing enchondral and osteochondral defects as well as arrangement for carrying out the method
US6251876B1 (en) 1996-06-21 2001-06-26 Fidia, S.P.A. Autocross-linked hyaluronic acid and related pharmaceutical compositions for the treatment of arthropathies
US6171344B1 (en) 1996-08-16 2001-01-09 Children's Medical Center Corporation Bladder submucosa seeded with cells for tissue reconstruction
US6280473B1 (en) 1996-08-19 2001-08-28 Macropore, Inc. Resorbable, macro-porous, non-collapsing and flexible membrane barrier for skeletal repair and regeneration
US6206931B1 (en) 1996-08-23 2001-03-27 Cook Incorporated Graft prosthesis materials
WO1998022158A2 (en) 1996-08-23 1998-05-28 Cook Biotech, Incorporated Graft prosthesis, materials and methods
WO1998022158A3 (en) 1996-08-23 1998-10-22 Cook Biotech Inc Graft prosthesis, materials and methods
US6666892B2 (en) 1996-08-23 2003-12-23 Cook Biotech Incorporated Multi-formed collagenous biomaterial medical device
US20020099448A1 (en) 1996-08-23 2002-07-25 Michael C. Hiles Multi-formed collagenous biomaterial medical device
US5989269A (en) 1996-08-30 1999-11-23 Vts Holdings L.L.C. Method, instruments and kit for autologous transplantation
US5759190A (en) 1996-08-30 1998-06-02 Vts Holdings Limited Method and kit for autologous transplantation
US20020173806A1 (en) 1996-08-30 2002-11-21 Verigen Transplantation Service International (Vtsi) Ag Method for autologous transplantation
US6379367B1 (en) 1996-08-30 2002-04-30 Verigen Transplantation Service International (Vtsi) Ag Method instruments and kit for autologous transplantation
US6283980B1 (en) 1996-08-30 2001-09-04 Verigen Transplantation Services Internt'l Method, instruments, and kit for autologous transplantation
US5863551A (en) 1996-10-16 1999-01-26 Organogel Canada Ltee Implantable polymer hydrogel for therapeutic uses
US6187039B1 (en) 1996-12-10 2001-02-13 Purdue Research Foundation Tubular submucosal graft constructs
US6099567A (en) 1996-12-10 2000-08-08 Purdue Research Foundation Stomach submucosa derived tissue graft
US6379710B1 (en) 1996-12-10 2002-04-30 Purdue Research Foundation Biomaterial derived from vertebrate liver tissue
US6358284B1 (en) 1996-12-10 2002-03-19 Med Institute, Inc. Tubular grafts from purified submucosa
US6126686A (en) 1996-12-10 2000-10-03 Purdue Research Foundation Artificial vascular valves
US6152935A (en) 1996-12-11 2000-11-28 Ethicon, Inc. Meniscal repair device having integral spring member
US6156044A (en) 1996-12-11 2000-12-05 Ethicon, Inc. Meniscal repair device
US6280474B1 (en) 1997-01-09 2001-08-28 Neucoll, Inc. Devices for tissue repair and methods for preparation and use thereof
US5866165A (en) 1997-01-15 1999-02-02 Orquest, Inc. Collagen-polysaccharide matrix for bone and cartilage repair
US6146385A (en) 1997-02-11 2000-11-14 Smith & Nephew, Inc. Repairing cartilage
US6224892B1 (en) 1997-03-01 2001-05-01 Smith & Nephew Plc Polyesterhydrogels
US6270530B1 (en) 1997-05-01 2001-08-07 C.R. Bard, Inc. Prosthetic repair fabric
US5993844A (en) 1997-05-08 1999-11-30 Organogenesis, Inc. Chemical treatment, without detergents or enzymes, of tissue to form an acellular, collagenous matrix
US5980524A (en) 1997-06-02 1999-11-09 Innovasive Devices, Inc. Device for repairing a meniscal tear in a knee and method
US5906997A (en) 1997-06-17 1999-05-25 Fzio Med, Inc. Bioresorbable compositions of carboxypolysaccharide polyether intermacromolecular complexes and methods for their use in reducing surgical adhesions
US6133325A (en) 1997-06-17 2000-10-17 Fziomed, Inc. Bioresorbable compositions of carboxypolysaccharide polyether intermacromolecular complexes and methods for their use in reducing surgical adhesions
US6869938B1 (en) 1997-06-17 2005-03-22 Fziomed, Inc. Compositions of polyacids and polyethers and methods for their use in reducing adhesions
US6034140A (en) 1997-06-17 2000-03-07 Fziomed, Inc. Bioresorbable compositions of carboxypolysaccharide polyether intermacromolecular complexes and methods for their use in reducing surgical adhesions
US6017301A (en) 1997-06-17 2000-01-25 Fziomed, Inc. Bioresorbable compositions of carboxypolysaccharide polyether intermacromolecular complexes and methods for their use in reducing surgical adhesions
US6692499B2 (en) 1997-07-02 2004-02-17 Linvatec Biomaterials Oy Surgical fastener for tissue treatment
US6264702B1 (en) 1997-08-01 2001-07-24 Sofradim Production Composite prosthesis for preventing post-surgical adhesions
US6010525A (en) 1997-08-01 2000-01-04 Peter M. Bonutti Method and apparatus for securing a suture
US6451032B1 (en) 1997-08-01 2002-09-17 Sofradim Production Composite prosthesis for preventing post-surgical adhesions and method for obtaining same
US6056752A (en) 1997-10-24 2000-05-02 Smith & Nephew, Inc. Fixation of cruciate ligament grafts
US6056778A (en) 1997-10-29 2000-05-02 Arthrex, Inc. Meniscal repair device
US6306156B1 (en) 1997-11-20 2001-10-23 Ron Clark Meniscus repair anchor system
US5954747A (en) 1997-11-20 1999-09-21 Clark; Ron Meniscus repair anchor system
US6267957B1 (en) 1998-01-20 2001-07-31 Howard Green Attaching agents to tissue with transglutaminase and a transglutaminase substrate
US5899939A (en) 1998-01-21 1999-05-04 Osteotech, Inc. Bone-derived implant for load-supporting applications
US6098347A (en) 1998-01-21 2000-08-08 Jaeger; Leroy L. Metal framed geodesic structure
US6068648A (en) 1998-01-26 2000-05-30 Orthodyne, Inc. Tissue anchoring system and method
US6294041B1 (en) 1998-02-06 2001-09-25 Osteotech, Inc. Method for an osteoimplant manufacture
US5958874A (en) 1998-02-18 1999-09-28 The Research Foundation Of State University Of New York Recombinant fibronectin-based extracellular matrix for wound healing
US6056777A (en) 1998-02-27 2000-05-02 Mcdowell; Charles L. Method and device for regenerating cartilage in articulating
US6214047B1 (en) 1998-03-10 2001-04-10 University Of Cincinnati Article and method for coupling muscle to a prosthetic device
US6179872B1 (en) 1998-03-17 2001-01-30 Tissue Engineering Biopolymer matt for use in tissue repair and reconstruction
US5993475A (en) 1998-04-22 1999-11-30 Bristol-Myers Squibb Co. Tissue repair device
US6027744A (en) 1998-04-24 2000-02-22 University Of Massachusetts Medical Center Guided development and support of hydrogel-cell compositions
JPH11319068A (en) 1998-05-12 1999-11-24 Menicon Co Ltd Base material for artificial skin and production thereof
US6265333B1 (en) 1998-06-02 2001-07-24 Board Of Regents, University Of Nebraska-Lincoln Delamination resistant composites prepared by small diameter fiber reinforcement at ply interfaces
US6572650B1 (en) 1998-06-05 2003-06-03 Organogenesis Inc. Bioengineered vascular graft support prostheses
US5971987A (en) 1998-09-18 1999-10-26 Ethicon, Inc. Biocompatible absorbable polymer fastener and driver for use in surgical procedures
WO2000024437A2 (en) 1998-10-28 2000-05-04 Ashby Scientific Ltd. Textured and porous silicone rubber
WO2000024437A3 (en) 1998-10-28 2000-10-19 Ashby Scient Ltd Textured and porous silicone rubber
US6066160A (en) 1998-11-23 2000-05-23 Quickie Llc Passive knotless suture terminator for use in minimally invasive surgery and to facilitate standard tissue securing
US6409764B1 (en) 1998-12-03 2002-06-25 Charles F. White Methods and articles for regenerating bone or peridontal tissue
US20020165611A1 (en) 1998-12-22 2002-11-07 Robert-Jan Enzerink Graft material convenience package
US6306159B1 (en) 1998-12-23 2001-10-23 Depuy Orthopaedics, Inc. Meniscal repair device
US6319271B1 (en) 1998-12-30 2001-11-20 Depuy Orthopaedics, Inc. Suture locking device
US6293961B2 (en) 1998-12-30 2001-09-25 Ethicon, Inc. Suture locking device
US6326025B1 (en) 1998-12-30 2001-12-04 Depuy Orthopaedics, Inc Tissue reactive adhesive compositions
US6458158B1 (en) 1999-01-05 2002-10-01 Lifenet Composite bone graft, method of making and using same
US6214049B1 (en) 1999-01-14 2001-04-10 Comfort Biomedical, Inc. Method and apparatus for augmentating osteointegration of prosthetic implant devices
US6093201A (en) 1999-01-19 2000-07-25 Ethicon, Inc. Biocompatible absorbable polymer plating system for tissue fixation
US6383221B1 (en) 1999-01-22 2002-05-07 Osteotech, Inc. Method for forming an intervertebral implant
US6517564B1 (en) 1999-02-02 2003-02-11 Arthrex, Inc. Bioabsorbable tissue tack with oval-shaped head and method of tissue fixation using same
US6440444B2 (en) 1999-02-23 2002-08-27 Osteotech, Inc. Load bearing osteoimplant and method of repairing bone using the same
US6251143B1 (en) 1999-06-04 2001-06-26 Depuy Orthopaedics, Inc. Cartilage repair unit
US6288043B1 (en) 1999-06-18 2001-09-11 Orquest, Inc. Injectable hyaluronate-sulfated polysaccharide conjugates
US6355699B1 (en) 1999-06-30 2002-03-12 Ethicon, Inc. Process for manufacturing biomedical foams
US6333029B1 (en) 1999-06-30 2001-12-25 Ethicon, Inc. Porous tissue scaffoldings for the repair of regeneration of tissue
US6652872B2 (en) 1999-07-06 2003-11-25 Ramat At Tel Aviv University Ltd. Scaffold formed of tissue treated to eliminate cellular and cytosolic elements
US6447517B1 (en) 1999-07-23 2002-09-10 Ethicon, Inc. Instrument for inserting graft fixation device
US6364884B1 (en) 1999-07-23 2002-04-02 Ethicon, Inc. Method of securing a graft using a graft fixation device
US20020095157A1 (en) 1999-07-23 2002-07-18 Bowman Steven M. Graft fixation device combination
US6423073B2 (en) 1999-07-23 2002-07-23 Ethicon, Inc. Instrument for inserting graft fixation device
US6436110B2 (en) 1999-07-23 2002-08-20 Ethicon, Inc. Method of securing a graft using a graft fixation device
EP1070487B1 (en) 1999-07-23 2005-09-14 Ethicon, Inc. Graft fixation device
US6179840B1 (en) 1999-07-23 2001-01-30 Ethicon, Inc. Graft fixation device and method
US6497707B1 (en) 1999-07-23 2002-12-24 Ethicon, Inc. Graft fixation device combination
US20020052628A1 (en) 1999-07-23 2002-05-02 Bowman Steven M. Graft fixation device and method
US20020169465A1 (en) 1999-07-23 2002-11-14 Bowman Steven M. Graft fixation device
US6497650B1 (en) 1999-07-28 2002-12-24 C. R. Bard, Inc. Hernia prosthesis
US6596296B1 (en) 1999-08-06 2003-07-22 Board Of Regents, The University Of Texas System Drug releasing biodegradable fiber implant
US6290711B1 (en) 1999-08-13 2001-09-18 Innovasive Devices, Inc. Connector device and method for surgically joining and securing flexible tissue repair members
US20010024658A1 (en) 1999-08-17 2001-09-27 Feng-Jing Chen Pharmaceutical dosage form for oral administration of hydrophilic drugs, particularly low molecular weight heparin
US6458383B2 (en) 1999-08-17 2002-10-01 Lipocine, Inc. Pharmaceutical dosage form for oral administration of hydrophilic drugs, particularly low molecular weight heparin
US6592623B1 (en) 1999-08-31 2003-07-15 Virginia Commonwealth University Intellectual Property Foundation Engineered muscle
US6319258B1 (en) 1999-09-29 2001-11-20 Ethicon, Inc. Absorbable rivet/pin applier for use in surgical procedures
US6273893B1 (en) 1999-11-10 2001-08-14 Ethicon, Inc. Absorbable rivet/pin applier for use in surgical procedures
US20020019649A1 (en) 1999-12-02 2002-02-14 Smith & Nephew, Inc., Delaware Corporation Closure device and method for tissue repair
WO2001039694A3 (en) 1999-12-03 2001-12-20 Univ Leeds Repair of damaged tissue
WO2001039694A2 (en) 1999-12-03 2001-06-07 University Of Leeds Repair of damaged tissue
US6373221B2 (en) 1999-12-27 2002-04-16 Kabushiki Kaisha Toyoda Jidoshokki Seisakusho Charger coupling
US6508821B1 (en) 2000-01-28 2003-01-21 Depuy Orthopaedics, Inc. Soft tissue repair material fixation apparatus and method
US6371958B1 (en) 2000-03-02 2002-04-16 Ethicon, Inc. Scaffold fixation device for use in articular cartilage repair
WO2001070293A1 (en) 2000-03-18 2001-09-27 The University Of Nottingham Polymeric composite materials and their manufacture
US6566345B2 (en) 2000-04-28 2003-05-20 Fziomed, Inc. Polyacid/polyalkylene oxide foams and gels and methods for their delivery
US20010043943A1 (en) 2000-05-22 2001-11-22 Coffey Arthur C. Combination SIS and vacuum bandage and method
US20040059431A1 (en) 2000-08-04 2004-03-25 Plouhar Pamela L. Reinforced small intestinal submucosa
US20020038151A1 (en) 2000-08-04 2002-03-28 Plouhar Pamela L. Reinforced small intestinal submucosa (SIS)
US20030023316A1 (en) 2000-08-04 2003-01-30 Brown Laura Jean Hybrid biologic-synthetic bioabsorable scaffolds
US6638312B2 (en) 2000-08-04 2003-10-28 Depuy Orthopaedics, Inc. Reinforced small intestinal submucosa (SIS)
US20020090725A1 (en) 2000-11-17 2002-07-11 Simpson David G. Electroprocessed collagen
US6812221B2 (en) 2000-11-21 2004-11-02 The Texas A&M University System FGF-affinity chromatography
US20020131989A1 (en) 2000-12-22 2002-09-19 Brown Kelly R. Implantable biodegradable devices for musculoskeletal repair or regeneration
US20020091444A1 (en) 2001-01-05 2002-07-11 Jun Yang Vascular tissue composition
US20030014126A1 (en) * 2001-06-28 2003-01-16 Patel Umesh H. Graft prosthesis devices containing renal capsule collagen
US20030049299A1 (en) 2001-07-16 2003-03-13 Prasanna Malaviya Porous delivery scaffold and method
US20030032961A1 (en) * 2001-07-16 2003-02-13 Pelo Mark Joseph Devices from naturally occurring biologically derived materials
WO2003007788A2 (en) 2001-07-16 2003-01-30 Depuy Products, Inc. Unitary surgical device and method
US20040220574A1 (en) 2001-07-16 2004-11-04 Pelo Mark Joseph Device from naturally occuring biologically derived materials
US20030021827A1 (en) 2001-07-16 2003-01-30 Prasanna Malaviya Hybrid biologic/synthetic porous extracellular matrix scaffolds
US20030078617A1 (en) 2001-07-16 2003-04-24 Schwartz Herbert E. Unitary surgical device and method
US20030044444A1 (en) 2001-07-16 2003-03-06 Prasanna Malaviya Porous extracellular matrix scaffold and method
US20030036797A1 (en) 2001-07-16 2003-02-20 Prasanna Malaviya Meniscus regeneration device and method
US20040143344A1 (en) 2001-07-16 2004-07-22 Prasanna Malaviya Implantable tissue repair device and method
US20030033021A1 (en) 2001-07-16 2003-02-13 Plouhar Pamela Lynn Cartilage repair and regeneration scaffold and method
US20030036801A1 (en) 2001-07-16 2003-02-20 Schwartz Herbert E. Cartilage repair apparatus and method
WO2003007790A2 (en) 2001-07-16 2003-01-30 Depuy Products, Inc. Hybrid biologic/synthetic porous extracellular matrix scaffolds
US20030033022A1 (en) 2001-07-16 2003-02-13 Plouhar Pamela Lynn Cartilage repair and regeneration device and method
US20050027307A1 (en) 2001-07-16 2005-02-03 Schwartz Herbert Eugene Unitary surgical device and method
WO2003097694A1 (en) 2002-05-21 2003-11-27 Colltech Australia Ltd Collagen and method for producing same
US6989034B2 (en) 2002-05-31 2006-01-24 Ethicon, Inc. Attachment of absorbable tissue scaffolds to fixation devices
US20040166169A1 (en) 2002-07-15 2004-08-26 Prasanna Malaviya Porous extracellular matrix scaffold and method
US8258124B2 (en) 2002-12-12 2012-09-04 Nycomed Gmbh Combination medicament
EP1593400A1 (en) 2004-05-04 2005-11-09 Depuy Products, Inc. Hybrid biologic-synthetic bioabsorbable scaffolds
US20050249772A1 (en) 2004-05-04 2005-11-10 Prasanna Malaviya Hybrid biologic-synthetic bioabsorbable scaffolds
US20050249771A1 (en) 2004-05-04 2005-11-10 Prasanna Malaviya Hybrid biologic-synthetic bioabsorbable scaffolds

Non-Patent Citations (168)

* Cited by examiner, † Cited by third party
Title
"Current Clinical Applications of SIS," Third SIS Symposium, Nov. 2000, USA.
"Handbook of Biodegradable Polymers" Hardwood Press 1997 (161-182).
"Handbook of Biodegradable Polymers" Hardwood Press 1997 (99-118).
"Polymer Preprints" (ACS Division of Polymer Chemistry), 1989. 30 (1): 498.
"Small Intestinal Submucosa," Third SIS Symposium, Nov. 2000, USA.
"Urschel Laboratories, Inc.—Comitrol Processor Model 1700", http://www.urschel.com/Comitrol—Processor—Model—1700—df.html. Printed Jul. 9, 2008, 2 pgs.
Aigner et al., "Collagens-major component of the physiological cartilage matrix, major target of cartilage degeneration, major tool in cartilage repair", Advanced Drug Delivery Reviews, vol. 55, No. 12, 2003, pp. 1569-1593.
Aiken et al., "Small Intestinal Submucosa as an Intra-Articular Ligamentous Graft Material: A Pilot Study in Dogs", Vet Comp Orthocedics Traumatology, 7:124-128, (1994).
Allman et al., Xenogeneic Extracellular Matrix Grafts Elicit a Th2-Restricted Immune Response, Transplantation, vol. 71, No. 11, Jun. 16, 2001, pp. 1631-1640.
Almon et al., "The Th2-Restricted Immune Response to Xenogeneic Small Intestinal Submucosa Does Not Influence Systemic Protective Immunity to Viral and Bacterial Pathogens", Tissue Engineering, vol. 8, No. 1, 2002, pp. 53-62.
Answers.com definition of "freeze-dry", accessed May 12, 2005. 6 pages. *
Answers.com, Definition of "freeze-dry", Accessed on May 12, 2005, 6 pgs.
Arnoczky et al., Meniscal repair using an exogenous fibrin clot-An experimental study of dogs, J. Bone Joint Surg. Am., 1988, 70(8), pp. 1209-1216.
Arnoczky et al., The microvasculature of the meniscus and its response to injury-An experimental study in the dog, Am. J. Sports Med., 1983, 11(3); pp. 131-141.
Arnoczky SP "Building a meniscus", Biological considerations, Clin Orthop Oct; 367 (suppl), S244-53, 1999.
Badylak , S., et al., "Naturally Occurring Extracellular Matrix as a Scaffold for Musculoskeletal Repair", Clin Orthop, 3675:S333-S3433, (1999).
Badylak et al., "The Use of Xenogeneic Small Intestinal Submucosa as a Biomaterial for Achille's Tendon Repair in a dog model", J Biomed Materials, 29:977-985, (1995).
Badylak, et al., "Different Configurations of Small Intestinal Submucosa as a Biomaterial for Achilles Tendon Repair in a Dog Model," First SIS Symposium, Dec. 1996, USA.
Bercovy et al., "Carbon-PGLA Prosthesis for Ligament Reconstruction Experimental Basis and Short Term Results in Man", Clin. Orthop. Relat. Res., (196), 159-68 (1985).
Bionix implants, Meniscus arrow advertisement, 1996.
Biscarini et al., "Growth of High Vacuum Sublimed Oligomer Thin Films", ACS Polymer Preprints, vol. 37, No. 2, 1998, pp. 618-619.
Biscarini et al., "Morphology and roughness of high-vacuum sublimed oligomer thin films", Thin Solid Films, vol. 439-443, 1996, pp. 284-285.
Biscarini et al., "Scaling Behavior of Anisotropic Organic Thin Films Grown in High-Vacuum", Physical Review Letters, vol. 78, No. 12, Mar. 24, 1997, pp. 2389-2392.
Boss et al., "Technical innovative: creation of a peripheral vascularized trough to enhance healing in cryopreserved meniscal allograft reconstruction", Knee Surg Sports Traumatol Arthrosc., 2000, 8(3), pp. 159-162.
Cheng & Teoh, "Surface modification of ultra thin poly (ÿ caprolactone) films using acrylic acid and collagen", Biomaterials, v25(11), pp. 1991-2001, 2004.
Clarke et al., "Intestine Submucosa and Polypropylene Mesh for Abdominal Wall Repair in Dogs", J Surg Res, 60:107-114, (1996).
Clearfix screw advertisement, 1998, Innovasive devices, Inc.
Cobb et al., "Histology after Dural Grafting with Small Intestinal Submucosa", Surgical Neurology, 46: 389-394, (1996).
Cobb et al., "Porcine Small Intestinal Submucosa as a Dural Substitute", Surgical Neurology, 51:99-104, (1999).
Cohn et al., "Biodegradable PEO/PLA block copolymers," Journal of Biomedical Materials Research, 1988, 22 (993-1009).
Cook, et al., "Comparison of SIS Cancellous Bone as Substrates for Three-Dimensional Culture of Canine Articular Chondrocytes," First SIS Symposium, Dec. 1996, USA.
Cook, et al., "Meniscal Regeneration in dogs Using Grafts of SIS," Second SIS Symposium, Dec. 1998, USA.
Cook, et al., "Tissue Engineering for Meniscal Repair Using SIS," Third SIS Symposium, Nov. 2000, USA.
Cook, J.L. et al., "Induction of Meniscal Regeneration in Dogs Using a Novel Biomaterial", Am J Sports Med, 27: 658, (1999).
COOK® News Releases, "Cook Incorporated Forms Dedicated Tissue Engineered Products Group", (Feb. 16, 2000).
COOK® News Releases, "COOK® Introduces Innovative Surgisis(TM) Soft Tissue Repair Biomaterial", (May 21, 2000).
COOK® News Releases, "COOK® Introduces Innovative Surgisis™ Soft Tissue Repair Biomaterial", (May 21, 2000).
COOK® News Releases, "COOK® Oasis(TM) Wound Dressing Biomaterial From COOK® Remodels Partial Thickness Skin Injuries", (Dec. 23, 1999).
COOK® News Releases, "COOK® Oasis™ Wound Dressing Biomaterial From COOK® Remodels Partial Thickness Skin Injuries", (Dec. 23, 1999).
COOK® News Releases, "FDA Clears Oasis(TM) Wound Dressing Biomaterial From COOK® for Full-Thickness Skin Injuries", (Jan. 24, 2000).
COOK® News Releases, "FDA Clears Oasis™ Wound Dressing Biomaterial From COOK® for Full-Thickness Skin Injuries", (Jan. 24, 2000).
Courtney et al., "Modification of polymer surfaces: optimization of approaches", Perfusion, v 18 (11), pp. 33-39, 2003.
Croll et al., "Controllable surface modification of Poly(lactic-co-glycolic acid) (PLGA) by hydrolysis or aminolysis I: physical, chemical, and theoretical aspects", Biomacromolecules, Mar.-Apr. 2004, 5(2): 463-473.
De Deyne, Ph.D., MPT et al., "The Adaptation of Perimuscular Connective Tissue During Distraction Osteogenesis", Clinical Orthopaedics and Related Research, No. 379, pp. 259-269.
de Groot et al., "Use of porous polyurethanes for meniscal reconstruction and meniscal protheses", Biomaterials, 1996, 17(2), pp. 183-173.
Definitions from Onelook.com for "trimethyten" and "trimethylene".
Definitions of "comminute" and "slurry", Dictionary.com; Accessed Sep. 20, 2005, 2 pgs.
Definitions of "intertwine" and "twine": American Heritage Dictionary of the English Language Online. Accessed Sep. 29, 2005. 2 pages. *
Definitions of "intertwine" and "twine." American Heritage Dictionary of the English Language Online. Accessed Sep. 29, 2005. 2 pages.
Dejardin, L.M. et al., "Use of small intestinal submucosal implants for regeneration of large fascial defects: an experimental study in dogs", J Biomed Mater Res, 46:203-211, (1999).
DiSilvestro et al., "Effects of Cross-Linking on the Mechanical Properties of a Porous Foam Scaffold of Small Intestine Submucosa", Society for Biomaterials 29th Annual Meeting Transactions, 2003, pp. 88.
Dix et al., "Myosin mRNA Accumulation and Myofibrillogenesis at the Myotendinous Junction of Stretched Muscle Fibers", The Journal of Cell Biology, vol. 111, Nov. 1990, pp. 1885-1894.
European Examination Report for European Patent Application No. 02752339.8-1219, Jul. 20, 2007, 5 pgs.
European Search Report for European Application No. 05257903.4-2115, Jun. 14, 2006, 3 pgs.
European Search Report for European Application No. 05257908.3-2107, Aug. 9, 2006, 3 pgs.
European Search Report for European Patent Application No. 02752339.8-1219, Mar. 19, 2007, 5 pgs.
Fan, et al., "A composite coating by electrolysis-induced collagen self-assembly and calcium phosphate minteralization", Biomaterials, Elsevier Science Publishers BV, XP004670973, vol. 26, No. 14, May 14, 2005, pp. 1623-1632.
Ferrand et al., "Directional Porosity of Porcine Small-Intestinal Submucosa", J Biomed Materials Res, 27:1235-1241, (1993).
Fox et al., Trephination of incomplete meniscal tears, Arthroscopy, 1993, 9(4); pp. 451-455.
Friess, "Collagen in drug delivery and tissue engineering", Advanced Drug Delivery Reviews, vol. 55, No. 12, 2003, pp. 1529-1530.
Gastel JA, Muirhead WR, Lifrak JT, Fadale PD, Hulstyn MJ, Labrador DP "Meniscal tissue regeneration using a collagenous biomaterial derived from porcine small intestine submucosa", Arthroscopy, February; 17(2): 151-159.
Gelger et al., "Collagen sponges for bone regeneration with rhBMP-2", Advanced Drug Delivery Reviews, vol. 55. No. 12, 2003, pp. 1613-1629.
Handbook of Biodegradable Polymers Hardwood Press 1997 (251-272).
Heywood, NI, et al. "Solids, Wet, Handling Problems" in McKetta, J.J., ed., Encyclopedia of Chemical Processing and Design, vol. 52 (1995, Marcel Dekker, New York). pp. 449-450. *
Hiles et al., "Mechanical properties of xenogeneic small-intestinal submucosa when used as an aortic graft in the dog", Journal of Biomedical Materials Research, vol. 29, 883-891, (1995).
Hiles et al., "Porosity of Porcine Small-Intestinal Submucosa for use as a Vascular Graft", J Biomed Materials Res, 27: 139-144 (1993).
Hodde and Hiles, "Bioactive FGF-2 in sterilized extracellular matrix", Wounds, 13(5): 195-201 (2001).
Hodde et al., "Fibronectin peptides mediate HMEC adhesion to porcine-derived extracellular matrix", Biomaterials, vol. 23, 2002, pp. 1841-1848.
Hodde et al., "Glycosaminoglycan Content of Small Intestinal Submucosa: A Bioscaffold for Tissue Replacement", Tissue Engineering, 2:3 209-217, (1996).
Hodde et al., "The Effect of Range of Motion Upon Remodeling of Small Intestinal Submucosa (SIS) when used as an Achilles Tendon Repair Material in the Rabbit", Tissue Engineering 3, 1:27-37, (1997).
Hodde et al., "Wounds: A Compendium of Clinical Research and Practice", Website: http:www.hmpcommunications.com/WNDS, Printed: Jul. 12, 2005, 7 pgs.
Hodde, "Naturally Occurring Scaffolds for Soft Tissue Repair and Regeneration", Tissue Engineering, vol. 8, No. 2, 2002, pp. 295-308.
Hodde, et al., "Glycosaminoglycan Content of Small Intestinal Submucosa: A Potential for GAG-Growth Interactions in SIS-Mediated Healing", First Symposium, Dec. 1996, USA.
Hodde, et al., "Vascular Endothelial Growth Factor in Porcine-Derived Extracellular Matrix", Endothelium, vol. 8(1), 2001, pp. 11-24.
Hoffman, "SIS Disc Replacement for the Temporomandibular Joint," Third SIS Symposium, Nov. 2000, USA.
How to Cut Meat Products. 2001. Urschel Corp. Accessed online at fr.urschel.com/literature/HTCMeat.pdf on Oct. 3, 2005. 8 pages. *
Hurst et al., "Mapping of the distribution of significant proteins and proteoglycans in small intestinal submucosa by fluorescence microscopy", J. Biomater. Sci. Polymer Edn., vol. 12. No. 11, 2001, pp. 1267-1279.
Ide et al., "Collagen Hybridization with Poly(l-Lactic Acid) Braid Promotes Ligament Cell Migration", Mater. Sci. Eng. C, 17(1-2), 95-99 (2001).
Instrument makar, inc., Meniscus mender II, 1989.
J.S. Pieper et al "Preparation and characterization of porous crosslinked collagenous matrices containing bioavailable chondroitin suplhate" Biomaterials 1999, 20: 847-858.
J.S. Pieper et al. Attachment of glycosaminoglycans to collangenous matrices modulates the tissue response in rats, Biomaterials 2000, 21 (16): 1689-1699.
Kaeding, "Use of SIS in the Surgical Treatment of Chronic Symptomatic Patella Tendinosis," Third SIS Symposium, Nov. 2000, USA.
Kandel, et al., "SIS and Reconstituted Cartilage and Its Use in Joint Resurfacing of Focal Defects in Rabbits," First SIS Symposium, Dec. 1996, USA.
Kannus et al., "The effect of immobilization on myotendinous junction: an ultrastructural, histochemical and immunohistochemical study", Acta Physical Scandinavica, vol. 144, 1992, pp. 387-394.
Klawitter et al., "An Evaluation of Bone Growth Into Porous High Density Polyethylene", J. Biomed. Materials Res., vol. 10, (1976) pp. 311-323.
Klompmaker et al., "Meniscal replacement using a porous polymer prosthesis: a preliminary study in the dog.", Biomaterials, 1996, 17(12), pp. 1169-1175.
Klootwyk, et al., "The Use of Xenographic SIS as a Biomaterial for Achilles Tendon Repair in Dogs," First SIS Symposium, Dec. 1996, USA.
Knapp, et al., "Biocompatibility of Small-Intestine Submucosa in Urinary Tract as Augmentation Cystoplasty Graft and Injectable Suspension", J Endourology, 8:125-130, (1994).
Krëma, "Nonwoven Textiles", Textile Trade Press, Manchester, England, 1962, 6 pgs.
Kristen Billiar et al. "Effects of carbodiimide crosslinking conditions on the physical properties of laminated intestinal submucosa", J. Biomed. Mater. Res. 2001, 51(1): 101-108.
Kropp et al, Characterization of Small Intestinal Submucosa Regenerated Canine Detrusor: Assessment of Reinnervation, In Vitro Compliance and contractility, J. of Urol., 156:599-607, (1996).
Kropp et al., "Experimental Assessment of Small Intestinal Submucosa as a Bladder Wall Substitute", Urology 446:396-400, (1995).
Kropp et al., "Regenerative Bladder Augmentation: A Review of the Initial Preclinical Studies with Porcine Small Intestinal Submucosa", Muscle, Matrix, and Bladder Function, Plenum Press, New York, (1995).
Kropp et al., "Regenerative Urinary Bladder Augmentation Using Small Intestinal Submucosa: Urodynamic and Histopatholoaic Assessment in Long-Term Canine Bladder Augmentations", Journal of Urology, 155:2098-2104, (1996).
Kwon et al., "Fibroblast culture on surface-modified poly (glycolide-co-ÿ-caprolactone) scaffold for soft tissue regeneration", J. Biomater Sci Polym ed. 2001, 12(10) 1147-60.
Kyumin Whang "A biodegradable polymer scaffold for delivery of osteotropic factors" Biomaterials 2000, 21 (24): 2545-2551.
Lenz, et al., "SIS as an ACL Replacement in Dogs and Goats," First Symposium, Dec. 1996, USA.
Lifrak, et al., "Enhanced Repair of Goat Meniscal Defects Using Porcine Small Intestinal Submucosa (SIS)," Third SIS Symposium, Nov. 2000, USA.
Ma et al., "Biodegradable Polymer Scaffolds with Well-Defined Interconnected Spherical Pore Network", Tissue Engineering, vol. 7, No. 1, 2001, pp. 23-33.
Ma et al., "Microtubular architecture of biodegradable polymer scaffolds", J. Biomed. Materials Res., vol. 56, No. 4, 2001, pp. 469-477.
Ma et al., "Synthetic nano-scale fibrous extracellular matrix", Journal Biomedical Materials Research, XP002380122, vol. 46, No. 1, 1999, pp. 60-72.
Marino et al., "Piezoelectricity in collagen films", Calcified Tissue International, XP009066271, vol. 31, No. 3, 1980, pp. 257-259.
Marino et al., "The effect of electric current on rat tail tendon collagen in solution", Calcified Tissue Research, XP009066270, vol. 4, No. 4, 1970, pp. 330-338.
Matthews et al., "Electrospinning of Collagen Type II: A Feasibility Study", Journal of Bioactive and Compatible Polymers, vol. 18, Mar. 2003, pp. 125-134.
McPherson, Ph.D. et al., "Characterization of Fibronectin Derived from Porcine Small Intestinal Submucosa", Tissue Engineering, vol. 4, No. 1, 1998, pp. 75-83.
Merriam-Webster Online Dictionary definitions of "suspension," "suspend," "cohesive," and "cohesion." Accessed Mar. 29, 2006. 5 pages. *
Metcalf et al., "Surgical technique for xenograft (SIS) augmentation of rotator-cuff repairs", Op Tech Orthop, 12(3): 204-208, 2002.
Michael W. King, Ph.D., online article entitled "Extracellular Matrix (ECM)", at http://web.indstate.edu/thcme/mwking/extracellular—matrix.html, Jul. 6, 2006.
Miller et al., Electric field-assisted assembly of type-I collagen for applications in biomedical micro-systems, Proceedings of IMECE 2005, 2005 ASME Int'l Mech. Engr. Cong. and Expo., XP009065904, Nov. 2005, pp. 1-3.
Moore, et al., "Bridging Segmental Defects in Long Bones With Intramedullary Tubes and Periosteal Sleeves Made From Small Intestinal Submucosa (SIS)," Third SIS Symposium, Nov. 2000, USA.
Nehrer et al., "Matrix collagen type and pore size influence behavior of seeded canine chondrocytes", Biomaterials, vol. 18, No. 11, 1997, pp. 769-776.
Niyibizi et al., "Human Placenta Type V Collagens Evidence for the Existence of an Alpha-1-V-Alpha-2-V-Alpha-3-V Collagen Molecule", Journal of Biological Chemistry, XP002380121, vol. 259, No. 22, 1984, pp. 14170-14174.
Obermiller, et al., "Suture Retention Strength of SIS," First SIS Symposium, Dec. 1996, USA.
O'Grady et al., "Global regulatory registration requlrements for collagen-based combination products: points to consider", Advanced Drug Delivery Reviews, vol. 55, No. 12, 2003, pp. 1699-1721.
Ojha, et al., "PGA-Plla Versus Small Intestinal Submucosa (SIS): A Comparison of Neo-Cartilage Grown From Two Scaffold Materials," Third SIS Symposium, Nov. 2000, USA.
Olsen et al., "Recombinant collagen and gelatin for drug delivery", Advanced Drug Delivery Reviews, vol. 55, No. 12, 2003, pp. 1547-1557.
O'Meara, Patrick, "The basic science of meniscus repair," Orthopaedic review, Jun. 1993, pp. 681-686.
On-line Medical Dictionary definition of "extracellular matrix" located at http://cancerweb.ncl.ac.uk/cgibin/omd?extracellular+matrix.
Owen, et al., "Calcification Potential of Small Intestinal Submucosa in a Rat Subcutaneous Model", Journal of Surgical Research, vol. 71, pp. 179-186, 1997.
P. K. Chu et al., "Plasma-surface modification of biomaterials", Materials Science and Engineering, Reports: A Review Journal, vol. 36, No. 5-6, Mar. 29, 2002, pp. 143-206.
P.B. van Wachem et al. "In vivo biocompatability of carbodiimide-crosslinked collagen matrices: Effects of crosslink density, heparin immobilization, and bFGF loading" J. Biomed. Mater. Res. 2001, 55 (3):368-378.
Paulino, et al., "The Use of an SIS-PGA Composite Graft for Repair of Cartilage Defect," Dec. 1998, USA.
Prevel et al., "Small Intestinal Submucosa: Utilization as a Wound Dressing in Full-Thickness Rodent Wounds", Ann Plast Surg.,35:381-388, (1995).
Prevel et al., "Small Intestinal Submucosa: Utilization for Repair of Rodent Abdominal Wall Defects", Ann Plast Surg, 35:374-380, (1995).
Resin Technology Group, LLC. "Viscosity chart," http://www.resintechgroup.com/tables/viscosity.html, accessed online Mar. 29, 2006. 1 page. *
Rodeo, "Arthroscopic meniscal repair with use of the outside-in technique", Instr. Course Lect., 2000, 49, pp. 195-206.
Rodeo, "Meniscal allografts-where do we stand?", Am. J. Sports Med., 2001, 29(2), pp. 246-281.
Rodkey et al., "A clinical study of collagen meniscus implants to restore the injured meniscus", Clin. Orthop., 1999, 49(387 Suppl.), pp. S281-S292.
Ruszczak et al., "Collagen as a carrier for on-site delivery of antibacterial drugs", Advanced Drug Delivery Reviews, vol. 55, No. 12, 2003, pp. 1679-1698.
Sacks, M.S., et al., "Quantification of the fiber architecture and biaxial mechanical behavior of porcine intestinal submucosa", J Biomed Mater Res, 46:1-10, (1999).
Salem et al., "Interactions of 3T3 fibroblasts and endothelial with defined pore ffeatures", J. Biomed Materials Res., vol. 61, No. 2, 2002, pp. 212-217.
Sandusky, et al., "Healing Comparison of Small Intestine Submucosa and ePTFE Grafts in the Canine Carotid Artery", J. Surg.Res., 58:415-420, (1995).
Sarikaya et al., "Antimicrobial Activity Associated with Extracellular Matrices", Tissue Engineering, vol. 8, No. 1, 2002, pp. 63-71.
Shelton, et al., "Repair of the Canine Medial Meniscus using SIS: A Feasibility Study," Second SIS Symposium, Dec. 1998, USA.
Shors, Coralline Bone Graft Substitutes, Orthopaedic Clinics of North America, Bone Grafting and Bone Graft Substitutes, vol. 30, No. 4, Oct. 1999, pp. 599-613.
Siegel et al., "Meniscal allografts", Clin Sports Med., 1993, 12(1), pp. 59-80.
Solchaga, et al., "SIS as Delivery Vehicle for Mesenchymal Progenitor Cells," Dec. 1998, USA.
Spaans et al., "Solvent-free fabrication of micro-porous polyurethane amide and polyurethane-urea scaffolds for repair and replacement of the knee-joint meniscus", Biomaterials, 2000, 21(23), pp. 2453-2460.
Stollsteimer et al., "Meniscal allograft transplantation: a 1- to 5-year follow-up of 22 patients", Arhroscopy, 2000, 16(4), pp. 343-347.
Stone et al., "Regeneration of meniscal cartilage with use of a collagen scaffold-Analysis of Preliminary data", J. Bone Joint Surg. Am., 1997, 79(12), pp. 1770-1777.
Suckow, M.A., "Enhanced Bone Regeneration Using Porcine Small Intestinal Submucosa", J. Invest Surg, 12: 277, (1999).
Supplementary European Search Report, Appln No. 02753403.1 (PCT/US 223190) dated Dec. 21, 2006 (3 pages).
Surgical dynamics, meniscal stapler advertisement, 1997.
Sweigart et al., "Toward tissue engineering of the knee meniscus", Tissue Eng., 2001, 7(2), pp. 111-129.
Tan W, Krishnaraj R, Desai TA "Evaluation of nanostructured composite collagen-chitosan matrices for tissue engineering", Tissue Eng Apr; 7(2): 203-210, 2001.
The Encyclopedia of Polymer Science, 1988 (13) 31-41.
Tidball, Ph.D. et al., "Myotendinous Junction Injury in Relation to Junction Structure and Molecular Composition", Exercise & Sport Sciences Reviews, vol. 19, 1991, pp. 419-445.
Tomasek and Gifford, "Small Intestinal Submucosa Matrix Regulates the Differentiation of Myofibroblasts," Third SIS Symposium, Nov. 2000, USA.
Tomczak and Kaeding, "Use of SIS in the Surgical Treatment of Tendinosis About the Foot and Ankle," Third SIS Symposium, Nov. 2000, USA.
Toombs and May, "Clinical Follow-Up of Three Canine ACL Reconstructions Using an SIS ACL Device," Dec. 1998, USA.
Toshimitsu Momose et al. "Surface modification of extrasynovial tendon by chemically modified hyaluronic acid coating" J. Biomed. Mater. Res. 2002, 59: 219-224.
Tullius, et al., "Differential Permeabilty of SIS," First SIS Symposium, Dec. 1996, USA.
Vaught et al., "Detrusor Regeneration in the Rat Using Porcine Small Intestinal Submucosa Grafts: Functional Innervation and Receptor Expression", J. Urol., 155:374-378, (1996).
Voytik-Harbin & Badylak, "Induction of Osteogenic Activity by Small Intestinal Submucosa in Rat Calvaria Non-union Defects," First SIS Symposium. Dec. 1996, USA.
Voytik-Harbin et al., "Application and Evaluation of the AlamarBlue Assay for Cell Growth and Survival of Fibroblasts", Journal of Immunological Methods, In Vitro Cell Bio-Animal, 34: 2399-246, (1998).
Voytik-Harbin et al., "Identification of Extractable Growth Factors from Small Intestinal Submucosa", Journal of Cellular Biochemistry, vol. 67, 1997, pp. 478-491.
Wan et al., "Cell adhesion on gaseous plasma modified poly-(L-lactide) surface under shear stress field", Biomaterials, v24(21), pp. 3757-3764, 2003.
Wang, et al., "Small Intestinal Submucosa Enhances Healing of Medical Collateral Ligament in a Rabbit Model," Third SIS Symposium, Nov. 2000, USA.
Wang, Experimental Study of Osteogenic Activity of Sintered Hydroxyapatite-On the Relationship of Sintering Temperature and Pore Size-, J. Jpn. Orthop. Assoc., vol. 64, 1990, pp. 847-859.
Welch, et al., "Healing of Canine Meniscal Defect with Small Intestinal Submucosa Implants," Dec. 1998, USA.
White et al., "Biomaterial Aspects of Interpore-200 Porous Hydroxyapatite", Dental Clinics of North America, Reconstructive Implant Surgery and Implant Prosthodontics 1, vol. 30, No. 1, pp. 49-67.
Wikipedia online definition of "hyaluronic acid" at http://en.wikipedia.org/wiki/Hyaluronate, Jul. 6, 2006.
Wiklerson, "Use of the Porcine Small Intestine Submucosal Tissue Graft and Repair of Rotator Cuff Tears," Third SIS Symposium, Nov. 2000, USA.
William G. Clancy, Jr., M.D., and Ben K. Graf, M.D., "Arthroscopic Meniscal Repair," ACUFEX Microsurigal Inc., advertisement, 1988.
Winters and Justin, "Clearfix meniscal screw", Innovasive devices, Inc. 1998.
Yang et al., "Effect of surface treatment on the biocompatibility of microbial polyhydroxyalkanoates", Biomaterials, v 23 (5), pp. 1391-1397, 2002.
Zhang et al., Design of nanostructured biological materials through self-assembly of peptides and proteins, MIT Current Opinion in chemical Biology, 2002, 6:865-871.
Zhu et al, "Immobilization of Biomacromolecules onto Aminolyzed Poly(L-lactic acid) toward Acceleration of Endothelium Regeneration", Tissue Engineering, v 10, pp. 53-61, 2004.

Cited By (832)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10293100B2 (en) 2004-07-28 2019-05-21 Ethicon Llc Surgical stapling instrument having a medical substance dispenser
US10716563B2 (en) 2004-07-28 2020-07-21 Ethicon Llc Stapling system comprising an instrument assembly including a lockout
US10383634B2 (en) 2004-07-28 2019-08-20 Ethicon Llc Stapling system incorporating a firing lockout
US11083456B2 (en) 2004-07-28 2021-08-10 Cilag Gmbh International Articulating surgical instrument incorporating a two-piece firing mechanism
US11116502B2 (en) 2004-07-28 2021-09-14 Cilag Gmbh International Surgical stapling instrument incorporating a two-piece firing mechanism
US11896225B2 (en) 2004-07-28 2024-02-13 Cilag Gmbh International Staple cartridge comprising a pan
US11890012B2 (en) 2004-07-28 2024-02-06 Cilag Gmbh International Staple cartridge comprising cartridge body and attached support
US10292707B2 (en) 2004-07-28 2019-05-21 Ethicon Llc Articulating surgical stapling instrument incorporating a firing mechanism
US11684365B2 (en) 2004-07-28 2023-06-27 Cilag Gmbh International Replaceable staple cartridges for surgical instruments
US10799240B2 (en) 2004-07-28 2020-10-13 Ethicon Llc Surgical instrument comprising a staple firing lockout
US10278702B2 (en) 2004-07-28 2019-05-07 Ethicon Llc Stapling system comprising a firing bar and a lockout
US11882987B2 (en) 2004-07-28 2024-01-30 Cilag Gmbh International Articulating surgical stapling instrument incorporating a two-piece E-beam firing mechanism
US11135352B2 (en) 2004-07-28 2021-10-05 Cilag Gmbh International End effector including a gradually releasable medical adjunct
US10568629B2 (en) 2004-07-28 2020-02-25 Ethicon Llc Articulating surgical stapling instrument
US10687817B2 (en) 2004-07-28 2020-06-23 Ethicon Llc Stapling device comprising a firing member lockout
US10485547B2 (en) 2004-07-28 2019-11-26 Ethicon Llc Surgical staple cartridges
US11812960B2 (en) 2004-07-28 2023-11-14 Cilag Gmbh International Method of segmenting the operation of a surgical stapling instrument
US10314590B2 (en) 2004-07-28 2019-06-11 Ethicon Llc Articulating surgical stapling instrument incorporating a two-piece e-beam firing mechanism
US9113954B2 (en) 2004-10-29 2015-08-25 DePuy Synthes Products, Inc. Coordinate instrument set
US11730474B2 (en) 2005-08-31 2023-08-22 Cilag Gmbh International Fastener cartridge assembly comprising a movable cartridge and a staple driver arrangement
US11272928B2 (en) 2005-08-31 2022-03-15 Cilag GmbH Intemational Staple cartridges for forming staples having differing formed staple heights
US11246590B2 (en) 2005-08-31 2022-02-15 Cilag Gmbh International Staple cartridge including staple drivers having different unfired heights
US10729436B2 (en) 2005-08-31 2020-08-04 Ethicon Llc Robotically-controlled surgical stapling devices that produce formed staples having different lengths
US11179153B2 (en) 2005-08-31 2021-11-23 Cilag Gmbh International Staple cartridges for forming staples having differing formed staple heights
US11399828B2 (en) 2005-08-31 2022-08-02 Cilag Gmbh International Fastener cartridge assembly comprising a fixed anvil and different staple heights
US10932774B2 (en) 2005-08-31 2021-03-02 Ethicon Llc Surgical end effector for forming staples to different heights
US10420553B2 (en) 2005-08-31 2019-09-24 Ethicon Llc Staple cartridge comprising a staple driver arrangement
US11172927B2 (en) 2005-08-31 2021-11-16 Cilag Gmbh International Staple cartridges for forming staples having differing formed staple heights
US11839375B2 (en) 2005-08-31 2023-12-12 Cilag Gmbh International Fastener cartridge assembly comprising an anvil and different staple heights
US10245032B2 (en) 2005-08-31 2019-04-02 Ethicon Llc Staple cartridges for forming staples having differing formed staple heights
US10869664B2 (en) 2005-08-31 2020-12-22 Ethicon Llc End effector for use with a surgical stapling instrument
US11793512B2 (en) 2005-08-31 2023-10-24 Cilag Gmbh International Staple cartridges for forming staples having differing formed staple heights
US11576673B2 (en) 2005-08-31 2023-02-14 Cilag Gmbh International Stapling assembly for forming staples to different heights
US10278697B2 (en) 2005-08-31 2019-05-07 Ethicon Llc Staple cartridge comprising a staple driver arrangement
US10842489B2 (en) 2005-08-31 2020-11-24 Ethicon Llc Fastener cartridge assembly comprising a cam and driver arrangement
US11484312B2 (en) 2005-08-31 2022-11-01 Cilag Gmbh International Staple cartridge comprising a staple driver arrangement
US11484311B2 (en) 2005-08-31 2022-11-01 Cilag Gmbh International Staple cartridge comprising a staple driver arrangement
US11771425B2 (en) 2005-08-31 2023-10-03 Cilag Gmbh International Stapling assembly for forming staples to different formed heights
US10842488B2 (en) 2005-08-31 2020-11-24 Ethicon Llc Fastener cartridge assembly comprising a fixed anvil and different staple heights
US11134947B2 (en) 2005-08-31 2021-10-05 Cilag Gmbh International Fastener cartridge assembly comprising a camming sled with variable cam arrangements
US10463369B2 (en) 2005-08-31 2019-11-05 Ethicon Llc Disposable end effector for use with a surgical instrument
US11090045B2 (en) 2005-08-31 2021-08-17 Cilag Gmbh International Staple cartridges for forming staples having differing formed staple heights
US10321909B2 (en) 2005-08-31 2019-06-18 Ethicon Llc Staple cartridge comprising a staple including deformable members
US10806449B2 (en) 2005-11-09 2020-10-20 Ethicon Llc End effectors for surgical staplers
US11793511B2 (en) 2005-11-09 2023-10-24 Cilag Gmbh International Surgical instruments
US10993713B2 (en) 2005-11-09 2021-05-04 Ethicon Llc Surgical instruments
US11883020B2 (en) 2006-01-31 2024-01-30 Cilag Gmbh International Surgical instrument having a feedback system
US10709468B2 (en) 2006-01-31 2020-07-14 Ethicon Llc Motor-driven surgical cutting and fastening instrument
US11051813B2 (en) 2006-01-31 2021-07-06 Cilag Gmbh International Powered surgical instruments with firing system lockout arrangements
US11051811B2 (en) 2006-01-31 2021-07-06 Ethicon Llc End effector for use with a surgical instrument
US11058420B2 (en) 2006-01-31 2021-07-13 Cilag Gmbh International Surgical stapling apparatus comprising a lockout system
US11000275B2 (en) 2006-01-31 2021-05-11 Ethicon Llc Surgical instrument
US10993717B2 (en) 2006-01-31 2021-05-04 Ethicon Llc Surgical stapling system comprising a control system
US10806479B2 (en) 2006-01-31 2020-10-20 Ethicon Llc Motor-driven surgical cutting and fastening instrument with tactile position feedback
US10653417B2 (en) 2006-01-31 2020-05-19 Ethicon Llc Surgical instrument
US11103269B2 (en) 2006-01-31 2021-08-31 Cilag Gmbh International Motor-driven surgical cutting and fastening instrument with tactile position feedback
US11660110B2 (en) 2006-01-31 2023-05-30 Cilag Gmbh International Motor-driven surgical cutting and fastening instrument with tactile position feedback
US10299817B2 (en) 2006-01-31 2019-05-28 Ethicon Llc Motor-driven fastening assembly
US10653435B2 (en) 2006-01-31 2020-05-19 Ethicon Llc Motor-driven surgical cutting and fastening instrument with tactile position feedback
US11793518B2 (en) 2006-01-31 2023-10-24 Cilag Gmbh International Powered surgical instruments with firing system lockout arrangements
US10463383B2 (en) 2006-01-31 2019-11-05 Ethicon Llc Stapling instrument including a sensing system
US10959722B2 (en) 2006-01-31 2021-03-30 Ethicon Llc Surgical instrument for deploying fasteners by way of rotational motion
US10675028B2 (en) 2006-01-31 2020-06-09 Ethicon Llc Powered surgical instruments with firing system lockout arrangements
US10426463B2 (en) 2006-01-31 2019-10-01 Ehticon LLC Surgical instrument having a feedback system
US11166717B2 (en) 2006-01-31 2021-11-09 Cilag Gmbh International Surgical instrument with firing lockout
US10952728B2 (en) 2006-01-31 2021-03-23 Ethicon Llc Powered surgical instruments with firing system lockout arrangements
US10918380B2 (en) 2006-01-31 2021-02-16 Ethicon Llc Surgical instrument system including a control system
US11278279B2 (en) 2006-01-31 2022-03-22 Cilag Gmbh International Surgical instrument assembly
US11224454B2 (en) 2006-01-31 2022-01-18 Cilag Gmbh International Motor-driven surgical cutting and fastening instrument with tactile position feedback
US11020113B2 (en) 2006-01-31 2021-06-01 Cilag Gmbh International Surgical instrument having force feedback capabilities
US11224427B2 (en) 2006-01-31 2022-01-18 Cilag Gmbh International Surgical stapling system including a console and retraction assembly
US11648024B2 (en) 2006-01-31 2023-05-16 Cilag Gmbh International Motor-driven surgical cutting and fastening instrument with position feedback
US11648008B2 (en) 2006-01-31 2023-05-16 Cilag Gmbh International Surgical instrument having force feedback capabilities
US10485539B2 (en) 2006-01-31 2019-11-26 Ethicon Llc Surgical instrument with firing lockout
US10893853B2 (en) 2006-01-31 2021-01-19 Ethicon Llc Stapling assembly including motor drive systems
US11246616B2 (en) 2006-01-31 2022-02-15 Cilag Gmbh International Motor-driven surgical cutting and fastening instrument with tactile position feedback
US11890008B2 (en) 2006-01-31 2024-02-06 Cilag Gmbh International Surgical instrument with firing lockout
US11801051B2 (en) 2006-01-31 2023-10-31 Cilag Gmbh International Accessing data stored in a memory of a surgical instrument
US10743849B2 (en) 2006-01-31 2020-08-18 Ethicon Llc Stapling system including an articulation system
US10463384B2 (en) 2006-01-31 2019-11-05 Ethicon Llc Stapling assembly
US11364046B2 (en) 2006-01-31 2022-06-21 Cilag Gmbh International Motor-driven surgical cutting and fastening instrument with tactile position feedback
US11890029B2 (en) 2006-01-31 2024-02-06 Cilag Gmbh International Motor-driven surgical cutting and fastening instrument
US11612393B2 (en) 2006-01-31 2023-03-28 Cilag Gmbh International Robotically-controlled end effector
US10842491B2 (en) 2006-01-31 2020-11-24 Ethicon Llc Surgical system with an actuation console
US11350916B2 (en) 2006-01-31 2022-06-07 Cilag Gmbh International Endoscopic surgical instrument with a handle that can articulate with respect to the shaft
US10420560B2 (en) 2006-06-27 2019-09-24 Ethicon Llc Manually driven surgical cutting and fastening instrument
US11272938B2 (en) 2006-06-27 2022-03-15 Cilag Gmbh International Surgical instrument including dedicated firing and retraction assemblies
US11622785B2 (en) 2006-09-29 2023-04-11 Cilag Gmbh International Surgical staples having attached drivers and stapling instruments for deploying the same
US11571231B2 (en) 2006-09-29 2023-02-07 Cilag Gmbh International Staple cartridge having a driver for driving multiple staples
US10568652B2 (en) 2006-09-29 2020-02-25 Ethicon Llc Surgical staples having attached drivers of different heights and stapling instruments for deploying the same
US10595862B2 (en) 2006-09-29 2020-03-24 Ethicon Llc Staple cartridge including a compressible member
US10448952B2 (en) 2006-09-29 2019-10-22 Ethicon Llc End effector for use with a surgical fastening instrument
US11382626B2 (en) 2006-10-03 2022-07-12 Cilag Gmbh International Surgical system including a knife bar supported for rotational and axial travel
US11877748B2 (en) 2006-10-03 2024-01-23 Cilag Gmbh International Robotically-driven surgical instrument with E-beam driver
US10517682B2 (en) 2007-01-10 2019-12-31 Ethicon Llc Surgical instrument with wireless communication between control unit and remote sensor
US11064998B2 (en) 2007-01-10 2021-07-20 Cilag Gmbh International Surgical instrument with wireless communication between a control unit of a robotic system and remote sensor
US11134943B2 (en) 2007-01-10 2021-10-05 Cilag Gmbh International Powered surgical instrument including a control unit and sensor
US10918386B2 (en) 2007-01-10 2021-02-16 Ethicon Llc Interlock and surgical instrument including same
US11291441B2 (en) 2007-01-10 2022-04-05 Cilag Gmbh International Surgical instrument with wireless communication between control unit and remote sensor
US11844521B2 (en) 2007-01-10 2023-12-19 Cilag Gmbh International Surgical instrument for use with a robotic system
US10945729B2 (en) 2007-01-10 2021-03-16 Ethicon Llc Interlock and surgical instrument including same
US11771426B2 (en) 2007-01-10 2023-10-03 Cilag Gmbh International Surgical instrument with wireless communication
US10952727B2 (en) 2007-01-10 2021-03-23 Ethicon Llc Surgical instrument for assessing the state of a staple cartridge
US11918211B2 (en) 2007-01-10 2024-03-05 Cilag Gmbh International Surgical stapling instrument for use with a robotic system
US11166720B2 (en) 2007-01-10 2021-11-09 Cilag Gmbh International Surgical instrument including a control module for assessing an end effector
US11350929B2 (en) 2007-01-10 2022-06-07 Cilag Gmbh International Surgical instrument with wireless communication between control unit and sensor transponders
US11849947B2 (en) 2007-01-10 2023-12-26 Cilag Gmbh International Surgical system including a control circuit and a passively-powered transponder
US10517590B2 (en) 2007-01-10 2019-12-31 Ethicon Llc Powered surgical instrument having a transmission system
US11812961B2 (en) 2007-01-10 2023-11-14 Cilag Gmbh International Surgical instrument including a motor control system
US11666332B2 (en) 2007-01-10 2023-06-06 Cilag Gmbh International Surgical instrument comprising a control circuit configured to adjust the operation of a motor
US11006951B2 (en) 2007-01-10 2021-05-18 Ethicon Llc Surgical instrument with wireless communication between control unit and sensor transponders
US11000277B2 (en) 2007-01-10 2021-05-11 Ethicon Llc Surgical instrument with wireless communication between control unit and remote sensor
US11839352B2 (en) 2007-01-11 2023-12-12 Cilag Gmbh International Surgical stapling device with an end effector
US11039836B2 (en) 2007-01-11 2021-06-22 Cilag Gmbh International Staple cartridge for use with a surgical stapling instrument
US10702267B2 (en) 2007-03-15 2020-07-07 Ethicon Llc Surgical stapling instrument having a releasable buttress material
US11337693B2 (en) 2007-03-15 2022-05-24 Cilag Gmbh International Surgical stapling instrument having a releasable buttress material
US10398433B2 (en) 2007-03-28 2019-09-03 Ethicon Llc Laparoscopic clamp load measuring devices
US11134938B2 (en) 2007-06-04 2021-10-05 Cilag Gmbh International Robotically-controlled shaft based rotary drive systems for surgical instruments
US11857181B2 (en) 2007-06-04 2024-01-02 Cilag Gmbh International Robotically-controlled shaft based rotary drive systems for surgical instruments
US11564682B2 (en) 2007-06-04 2023-01-31 Cilag Gmbh International Surgical stapler device
US11672531B2 (en) 2007-06-04 2023-06-13 Cilag Gmbh International Rotary drive systems for surgical instruments
US10327765B2 (en) 2007-06-04 2019-06-25 Ethicon Llc Drive systems for surgical instruments
US11648006B2 (en) 2007-06-04 2023-05-16 Cilag Gmbh International Robotically-controlled shaft based rotary drive systems for surgical instruments
US10368863B2 (en) 2007-06-04 2019-08-06 Ethicon Llc Robotically-controlled shaft based rotary drive systems for surgical instruments
US11147549B2 (en) 2007-06-04 2021-10-19 Cilag Gmbh International Stapling instrument including a firing system and a closure system
US10299787B2 (en) 2007-06-04 2019-05-28 Ethicon Llc Stapling system comprising rotary inputs
US11911028B2 (en) 2007-06-04 2024-02-27 Cilag Gmbh International Surgical instruments for use with a robotic surgical system
US10363033B2 (en) 2007-06-04 2019-07-30 Ethicon Llc Robotically-controlled surgical instruments
US11559302B2 (en) 2007-06-04 2023-01-24 Cilag Gmbh International Surgical instrument including a firing member movable at different speeds
US11154298B2 (en) 2007-06-04 2021-10-26 Cilag Gmbh International Stapling system for use with a robotic surgical system
US11013511B2 (en) 2007-06-22 2021-05-25 Ethicon Llc Surgical stapling instrument with an articulatable end effector
US11849941B2 (en) 2007-06-29 2023-12-26 Cilag Gmbh International Staple cartridge having staple cavities extending at a transverse angle relative to a longitudinal cartridge axis
US11925346B2 (en) 2007-06-29 2024-03-12 Cilag Gmbh International Surgical staple cartridge including tissue supporting surfaces
US10660640B2 (en) 2008-02-14 2020-05-26 Ethicon Llc Motorized surgical cutting and fastening instrument
US10307163B2 (en) 2008-02-14 2019-06-04 Ethicon Llc Detachable motor powered surgical instrument
US10765432B2 (en) 2008-02-14 2020-09-08 Ethicon Llc Surgical device including a control system
US11484307B2 (en) 2008-02-14 2022-11-01 Cilag Gmbh International Loading unit coupleable to a surgical stapling system
US10722232B2 (en) 2008-02-14 2020-07-28 Ethicon Llc Surgical instrument for use with different cartridges
US10716568B2 (en) 2008-02-14 2020-07-21 Ethicon Llc Surgical stapling apparatus with control features operable with one hand
US10542974B2 (en) 2008-02-14 2020-01-28 Ethicon Llc Surgical instrument including a control system
US10905426B2 (en) 2008-02-14 2021-02-02 Ethicon Llc Detachable motor powered surgical instrument
US10905427B2 (en) 2008-02-14 2021-02-02 Ethicon Llc Surgical System
US11571212B2 (en) 2008-02-14 2023-02-07 Cilag Gmbh International Surgical stapling system including an impedance sensor
US10898194B2 (en) 2008-02-14 2021-01-26 Ethicon Llc Detachable motor powered surgical instrument
US10925605B2 (en) 2008-02-14 2021-02-23 Ethicon Llc Surgical stapling system
US10682141B2 (en) 2008-02-14 2020-06-16 Ethicon Llc Surgical device including a control system
US11612395B2 (en) 2008-02-14 2023-03-28 Cilag Gmbh International Surgical system including a control system having an RFID tag reader
US10682142B2 (en) 2008-02-14 2020-06-16 Ethicon Llc Surgical stapling apparatus including an articulation system
US10463370B2 (en) 2008-02-14 2019-11-05 Ethicon Llc Motorized surgical instrument
US10265067B2 (en) 2008-02-14 2019-04-23 Ethicon Llc Surgical instrument including a regulator and a control system
US11464514B2 (en) 2008-02-14 2022-10-11 Cilag Gmbh International Motorized surgical stapling system including a sensing array
US10898195B2 (en) 2008-02-14 2021-01-26 Ethicon Llc Detachable motor powered surgical instrument
US11717285B2 (en) 2008-02-14 2023-08-08 Cilag Gmbh International Surgical cutting and fastening instrument having RF electrodes
US10743870B2 (en) 2008-02-14 2020-08-18 Ethicon Llc Surgical stapling apparatus with interlockable firing system
US11446034B2 (en) 2008-02-14 2022-09-20 Cilag Gmbh International Surgical stapling assembly comprising first and second actuation systems configured to perform different functions
US10779822B2 (en) 2008-02-14 2020-09-22 Ethicon Llc System including a surgical cutting and fastening instrument
US11801047B2 (en) 2008-02-14 2023-10-31 Cilag Gmbh International Surgical stapling system comprising a control circuit configured to selectively monitor tissue impedance and adjust control of a motor
US11638583B2 (en) 2008-02-14 2023-05-02 Cilag Gmbh International Motorized surgical system having a plurality of power sources
US10888330B2 (en) 2008-02-14 2021-01-12 Ethicon Llc Surgical system
US10639036B2 (en) 2008-02-14 2020-05-05 Ethicon Llc Robotically-controlled motorized surgical cutting and fastening instrument
US10874396B2 (en) 2008-02-14 2020-12-29 Ethicon Llc Stapling instrument for use with a surgical robot
US10806450B2 (en) 2008-02-14 2020-10-20 Ethicon Llc Surgical cutting and fastening instrument having a control system
US10743851B2 (en) 2008-02-14 2020-08-18 Ethicon Llc Interchangeable tools for surgical instruments
US10888329B2 (en) 2008-02-14 2021-01-12 Ethicon Llc Detachable motor powered surgical instrument
US10856866B2 (en) 2008-02-15 2020-12-08 Ethicon Llc Surgical end effector having buttress retention features
US11272927B2 (en) 2008-02-15 2022-03-15 Cilag Gmbh International Layer arrangements for surgical staple cartridges
US11154297B2 (en) 2008-02-15 2021-10-26 Cilag Gmbh International Layer arrangements for surgical staple cartridges
US11045189B2 (en) 2008-09-23 2021-06-29 Cilag Gmbh International Robotically-controlled motorized surgical instrument with an end effector
US10980535B2 (en) 2008-09-23 2021-04-20 Ethicon Llc Motorized surgical instrument with an end effector
US10765425B2 (en) 2008-09-23 2020-09-08 Ethicon Llc Robotically-controlled motorized surgical instrument with an end effector
US11812954B2 (en) 2008-09-23 2023-11-14 Cilag Gmbh International Robotically-controlled motorized surgical instrument with an end effector
US11871923B2 (en) 2008-09-23 2024-01-16 Cilag Gmbh International Motorized surgical instrument
US11617576B2 (en) 2008-09-23 2023-04-04 Cilag Gmbh International Motor-driven surgical cutting instrument
US11648005B2 (en) 2008-09-23 2023-05-16 Cilag Gmbh International Robotically-controlled motorized surgical instrument with an end effector
US11103241B2 (en) 2008-09-23 2021-08-31 Cilag Gmbh International Motor-driven surgical cutting instrument
US10898184B2 (en) 2008-09-23 2021-01-26 Ethicon Llc Motor-driven surgical cutting instrument
US10485537B2 (en) 2008-09-23 2019-11-26 Ethicon Llc Motorized surgical instrument
US10456133B2 (en) 2008-09-23 2019-10-29 Ethicon Llc Motorized surgical instrument
US10736628B2 (en) 2008-09-23 2020-08-11 Ethicon Llc Motor-driven surgical cutting instrument
US10420549B2 (en) 2008-09-23 2019-09-24 Ethicon Llc Motorized surgical instrument
US11684361B2 (en) 2008-09-23 2023-06-27 Cilag Gmbh International Motor-driven surgical cutting instrument
US11517304B2 (en) 2008-09-23 2022-12-06 Cilag Gmbh International Motor-driven surgical cutting instrument
US11406380B2 (en) 2008-09-23 2022-08-09 Cilag Gmbh International Motorized surgical instrument
US11617575B2 (en) 2008-09-23 2023-04-04 Cilag Gmbh International Motor-driven surgical cutting instrument
US11730477B2 (en) 2008-10-10 2023-08-22 Cilag Gmbh International Powered surgical system with manually retractable firing system
US11793521B2 (en) 2008-10-10 2023-10-24 Cilag Gmbh International Powered surgical cutting and stapling apparatus with manually retractable firing system
US10932778B2 (en) 2008-10-10 2021-03-02 Ethicon Llc Powered surgical cutting and stapling apparatus with manually retractable firing system
US11583279B2 (en) 2008-10-10 2023-02-21 Cilag Gmbh International Powered surgical cutting and stapling apparatus with manually retractable firing system
US9814803B2 (en) 2008-11-20 2017-11-14 Allosource Allografts combined with tissue derived stem cells for bone healing
US9808558B2 (en) 2008-11-20 2017-11-07 Allosource Allografts combined with tissue derived stem cells for bone healing
US20100161054A1 (en) * 2008-11-21 2010-06-24 Jason Park Reinforced Biologic Material
US8333803B2 (en) * 2008-11-21 2012-12-18 Lifecell Corporation Reinforced biologic material
US9421306B2 (en) 2008-11-21 2016-08-23 Lifecell Corporation Reinforced biologic material
US11129615B2 (en) 2009-02-05 2021-09-28 Cilag Gmbh International Surgical stapling system
US10420550B2 (en) 2009-02-06 2019-09-24 Ethicon Llc Motor driven surgical fastener device with switching system configured to prevent firing initiation until activated
US9848987B2 (en) 2009-02-27 2017-12-26 University of Pittsburgh — Of the Commonwealth System of Higher Education Joint bioscaffolds
US9277999B2 (en) * 2009-02-27 2016-03-08 University of Pittsburgh—of the Commonwealth System of Higher Education Joint bioscaffolds
US20140309739A1 (en) * 2009-02-27 2014-10-16 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Joint bioscaffolds
US20100222882A1 (en) * 2009-02-27 2010-09-02 Badylak Stephen F Joint bioscaffolds
US9314340B2 (en) * 2009-02-27 2016-04-19 University of Pittsburgh—of the Commonwealth System of Higher Education Joint bioscaffolds
US10751076B2 (en) 2009-12-24 2020-08-25 Ethicon Llc Motor-driven surgical cutting instrument with electric actuator directional control assembly
US11291449B2 (en) 2009-12-24 2022-04-05 Cilag Gmbh International Surgical cutting instrument that analyzes tissue thickness
US11478247B2 (en) 2010-07-30 2022-10-25 Cilag Gmbh International Tissue acquisition arrangements and methods for surgical stapling devices
US10548600B2 (en) 2010-09-30 2020-02-04 Ethicon Llc Multiple thickness implantable layers for surgical stapling devices
US11850310B2 (en) 2010-09-30 2023-12-26 Cilag Gmbh International Staple cartridge including an adjunct
US11925354B2 (en) 2010-09-30 2024-03-12 Cilag Gmbh International Staple cartridge comprising staples positioned within a compressible portion thereof
US11571215B2 (en) 2010-09-30 2023-02-07 Cilag Gmbh International Layer of material for a surgical end effector
US11911027B2 (en) 2010-09-30 2024-02-27 Cilag Gmbh International Adhesive film laminate
US10945731B2 (en) 2010-09-30 2021-03-16 Ethicon Llc Tissue thickness compensator comprising controlled release and expansion
US11559496B2 (en) 2010-09-30 2023-01-24 Cilag Gmbh International Tissue thickness compensator configured to redistribute compressive forces
US10987102B2 (en) 2010-09-30 2021-04-27 Ethicon Llc Tissue thickness compensator comprising a plurality of layers
US11583277B2 (en) 2010-09-30 2023-02-21 Cilag Gmbh International Layer of material for a surgical end effector
US11672536B2 (en) 2010-09-30 2023-06-13 Cilag Gmbh International Layer of material for a surgical end effector
US11883025B2 (en) 2010-09-30 2024-01-30 Cilag Gmbh International Tissue thickness compensator comprising a plurality of layers
US11540824B2 (en) 2010-09-30 2023-01-03 Cilag Gmbh International Tissue thickness compensator
US11602340B2 (en) 2010-09-30 2023-03-14 Cilag Gmbh International Adhesive film laminate
US10743877B2 (en) 2010-09-30 2020-08-18 Ethicon Llc Surgical stapler with floating anvil
US10888328B2 (en) 2010-09-30 2021-01-12 Ethicon Llc Surgical end effector
US10624861B2 (en) 2010-09-30 2020-04-21 Ethicon Llc Tissue thickness compensator configured to redistribute compressive forces
US11857187B2 (en) 2010-09-30 2024-01-02 Cilag Gmbh International Tissue thickness compensator comprising controlled release and expansion
US10869669B2 (en) 2010-09-30 2020-12-22 Ethicon Llc Surgical instrument assembly
US11298125B2 (en) 2010-09-30 2022-04-12 Cilag Gmbh International Tissue stapler having a thickness compensator
US10898193B2 (en) 2010-09-30 2021-01-26 Ethicon Llc End effector for use with a surgical instrument
US10463372B2 (en) 2010-09-30 2019-11-05 Ethicon Llc Staple cartridge comprising multiple regions
US11849952B2 (en) 2010-09-30 2023-12-26 Cilag Gmbh International Staple cartridge comprising staples positioned within a compressible portion thereof
US11083452B2 (en) 2010-09-30 2021-08-10 Cilag Gmbh International Staple cartridge including a tissue thickness compensator
US11395651B2 (en) 2010-09-30 2022-07-26 Cilag Gmbh International Adhesive film laminate
US10335148B2 (en) 2010-09-30 2019-07-02 Ethicon Llc Staple cartridge including a tissue thickness compensator for a surgical stapler
US10335150B2 (en) 2010-09-30 2019-07-02 Ethicon Llc Staple cartridge comprising an implantable layer
US10588623B2 (en) 2010-09-30 2020-03-17 Ethicon Llc Adhesive film laminate
US11737754B2 (en) 2010-09-30 2023-08-29 Cilag Gmbh International Surgical stapler with floating anvil
US11684360B2 (en) 2010-09-30 2023-06-27 Cilag Gmbh International Staple cartridge comprising a variable thickness compressible portion
US10363031B2 (en) 2010-09-30 2019-07-30 Ethicon Llc Tissue thickness compensators for surgical staplers
US11154296B2 (en) 2010-09-30 2021-10-26 Cilag Gmbh International Anvil layer attached to a proximal end of an end effector
US11812965B2 (en) 2010-09-30 2023-11-14 Cilag Gmbh International Layer of material for a surgical end effector
US10835251B2 (en) 2010-09-30 2020-11-17 Ethicon Llc Surgical instrument assembly including an end effector configurable in different positions
US11406377B2 (en) 2010-09-30 2022-08-09 Cilag Gmbh International Adhesive film laminate
US11529142B2 (en) 2010-10-01 2022-12-20 Cilag Gmbh International Surgical instrument having a power control circuit
US10695062B2 (en) 2010-10-01 2020-06-30 Ethicon Llc Surgical instrument including a retractable firing member
US9339387B2 (en) 2010-10-13 2016-05-17 Cibor, Inc. Synthetic bone grafts constructed from carbon foam materials
US9119728B2 (en) 2011-01-17 2015-09-01 Cibor, Inc. Reinforced carbon fiber/carbon foam intervertebral spine fusion device
US11504116B2 (en) 2011-04-29 2022-11-22 Cilag Gmbh International Layer of material for a surgical end effector
US10617420B2 (en) 2011-05-27 2020-04-14 Ethicon Llc Surgical system comprising drive systems
US10335151B2 (en) 2011-05-27 2019-07-02 Ethicon Llc Robotically-driven surgical instrument
US11129616B2 (en) 2011-05-27 2021-09-28 Cilag Gmbh International Surgical stapling system
US10780539B2 (en) 2011-05-27 2020-09-22 Ethicon Llc Stapling instrument for use with a robotic system
US10420561B2 (en) 2011-05-27 2019-09-24 Ethicon Llc Robotically-driven surgical instrument
US10524790B2 (en) 2011-05-27 2020-01-07 Ethicon Llc Robotically-controlled surgical stapling devices that produce formed staples having different lengths
US10980534B2 (en) 2011-05-27 2021-04-20 Ethicon Llc Robotically-controlled motorized surgical instrument with an end effector
US10383633B2 (en) 2011-05-27 2019-08-20 Ethicon Llc Robotically-driven surgical assembly
US11583278B2 (en) 2011-05-27 2023-02-21 Cilag Gmbh International Surgical stapling system having multi-direction articulation
US11439470B2 (en) 2011-05-27 2022-09-13 Cilag Gmbh International Robotically-controlled surgical instrument with selectively articulatable end effector
US11918208B2 (en) 2011-05-27 2024-03-05 Cilag Gmbh International Robotically-controlled shaft based rotary drive systems for surgical instruments
US10813641B2 (en) 2011-05-27 2020-10-27 Ethicon Llc Robotically-driven surgical instrument
US11266410B2 (en) 2011-05-27 2022-03-08 Cilag Gmbh International Surgical device for use with a robotic system
US10736634B2 (en) 2011-05-27 2020-08-11 Ethicon Llc Robotically-driven surgical instrument including a drive system
US11207064B2 (en) 2011-05-27 2021-12-28 Cilag Gmbh International Automated end effector component reloading system for use with a robotic system
US10485546B2 (en) 2011-05-27 2019-11-26 Ethicon Llc Robotically-driven surgical assembly
US11612394B2 (en) 2011-05-27 2023-03-28 Cilag Gmbh International Automated end effector component reloading system for use with a robotic system
US9381112B1 (en) 2011-10-06 2016-07-05 William Eric Sponsell Bleb drainage device, ophthalmological product and methods
US11065154B1 (en) 2011-10-06 2021-07-20 William Eric Sponsel Bleb drainage device, ophthalmic product and methods
WO2013062994A1 (en) 2011-10-25 2013-05-02 Biomimetic Therapeutics, Inc. Compositions and methods for treating full thickness burn injuries
WO2013062995A1 (en) 2011-10-25 2013-05-02 Biomimetic Therapeutics, Inc. Compositions and methods for treating deep partial and full thickness wounds and injuries
US9364328B2 (en) 2011-11-17 2016-06-14 Allosource Multi-piece machine graft systems and methods
US9744266B2 (en) 2011-12-19 2017-08-29 Allosource Flowable matrix compositions and methods
US9801976B2 (en) 2011-12-19 2017-10-31 Allosource Flowable matrix compositions and methods
US9801975B2 (en) 2011-12-19 2017-10-31 Allosource Flowable matrix compositions and methods
US8632489B1 (en) 2011-12-22 2014-01-21 A. Mateen Ahmed Implantable medical assembly and methods
US10695063B2 (en) 2012-02-13 2020-06-30 Ethicon Llc Surgical cutting and fastening instrument with apparatus for determining cartridge and firing motion status
US10667808B2 (en) 2012-03-28 2020-06-02 Ethicon Llc Staple cartridge comprising an absorbable adjunct
US11793509B2 (en) 2012-03-28 2023-10-24 Cilag Gmbh International Staple cartridge including an implantable layer
US11406378B2 (en) 2012-03-28 2022-08-09 Cilag Gmbh International Staple cartridge comprising a compressible tissue thickness compensator
US10441285B2 (en) 2012-03-28 2019-10-15 Ethicon Llc Tissue thickness compensator comprising tissue ingrowth features
US11918220B2 (en) 2012-03-28 2024-03-05 Cilag Gmbh International Tissue thickness compensator comprising tissue ingrowth features
US10959725B2 (en) 2012-06-15 2021-03-30 Ethicon Llc Articulatable surgical instrument comprising a firing drive
US11707273B2 (en) 2012-06-15 2023-07-25 Cilag Gmbh International Articulatable surgical instrument comprising a firing drive
US11278284B2 (en) 2012-06-28 2022-03-22 Cilag Gmbh International Rotary drive arrangements for surgical instruments
US11806013B2 (en) 2012-06-28 2023-11-07 Cilag Gmbh International Firing system arrangements for surgical instruments
US11058423B2 (en) 2012-06-28 2021-07-13 Cilag Gmbh International Stapling system including first and second closure systems for use with a surgical robot
US10874391B2 (en) 2012-06-28 2020-12-29 Ethicon Llc Surgical instrument system including replaceable end effectors
US11464513B2 (en) 2012-06-28 2022-10-11 Cilag Gmbh International Surgical instrument system including replaceable end effectors
US11510671B2 (en) 2012-06-28 2022-11-29 Cilag Gmbh International Firing system lockout arrangements for surgical instruments
US11779420B2 (en) 2012-06-28 2023-10-10 Cilag Gmbh International Robotic surgical attachments having manually-actuated retraction assemblies
US11622766B2 (en) 2012-06-28 2023-04-11 Cilag Gmbh International Empty clip cartridge lockout
US11039837B2 (en) 2012-06-28 2021-06-22 Cilag Gmbh International Firing system lockout arrangements for surgical instruments
US11857189B2 (en) 2012-06-28 2024-01-02 Cilag Gmbh International Surgical instrument including first and second articulation joints
US10485541B2 (en) 2012-06-28 2019-11-26 Ethicon Llc Robotically powered surgical device with manually-actuatable reversing system
US11141156B2 (en) 2012-06-28 2021-10-12 Cilag Gmbh International Surgical stapling assembly comprising flexible output shaft
US11602346B2 (en) 2012-06-28 2023-03-14 Cilag Gmbh International Robotically powered surgical device with manually-actuatable reversing system
US10420555B2 (en) 2012-06-28 2019-09-24 Ethicon Llc Hand held rotary powered surgical instruments with end effectors that are articulatable about multiple axes
US11109860B2 (en) 2012-06-28 2021-09-07 Cilag Gmbh International Surgical end effectors for use with hand-held and robotically-controlled rotary powered surgical systems
US11197671B2 (en) 2012-06-28 2021-12-14 Cilag Gmbh International Stapling assembly comprising a lockout
US10932775B2 (en) 2012-06-28 2021-03-02 Ethicon Llc Firing system lockout arrangements for surgical instruments
US11202631B2 (en) 2012-06-28 2021-12-21 Cilag Gmbh International Stapling assembly comprising a firing lockout
US11540829B2 (en) 2012-06-28 2023-01-03 Cilag Gmbh International Surgical instrument system including replaceable end effectors
US10639115B2 (en) 2012-06-28 2020-05-05 Ethicon Llc Surgical end effectors having angled tissue-contacting surfaces
US11007004B2 (en) 2012-06-28 2021-05-18 Ethicon Llc Powered multi-axial articulable electrosurgical device with external dissection features
US11141155B2 (en) 2012-06-28 2021-10-12 Cilag Gmbh International Drive system for surgical tool
US11534162B2 (en) 2012-06-28 2022-12-27 Cilag GmbH Inlernational Robotically powered surgical device with manually-actuatable reversing system
US11918213B2 (en) 2012-06-28 2024-03-05 Cilag Gmbh International Surgical stapler including couplers for attaching a shaft to an end effector
US11083457B2 (en) 2012-06-28 2021-08-10 Cilag Gmbh International Surgical instrument system including replaceable end effectors
US10383630B2 (en) 2012-06-28 2019-08-20 Ethicon Llc Surgical stapling device with rotary driven firing member
US11154299B2 (en) 2012-06-28 2021-10-26 Cilag Gmbh International Stapling assembly comprising a firing lockout
US10413294B2 (en) 2012-06-28 2019-09-17 Ethicon Llc Shaft assembly arrangements for surgical instruments
US10687812B2 (en) 2012-06-28 2020-06-23 Ethicon Llc Surgical instrument system including replaceable end effectors
US11241230B2 (en) 2012-06-28 2022-02-08 Cilag Gmbh International Clip applier tool for use with a robotic surgical system
US11373755B2 (en) 2012-08-23 2022-06-28 Cilag Gmbh International Surgical device drive system including a ratchet mechanism
US10335281B2 (en) 2013-02-22 2019-07-02 Allosource Cartilage mosaic compositions and methods
US11123193B2 (en) 2013-02-22 2021-09-21 Allosource Cartilage mosaic compositions and methods
US10575868B2 (en) 2013-03-01 2020-03-03 Ethicon Llc Surgical instrument with coupler assembly
US11529138B2 (en) 2013-03-01 2022-12-20 Cilag Gmbh International Powered surgical instrument including a rotary drive screw
US11246618B2 (en) 2013-03-01 2022-02-15 Cilag Gmbh International Surgical instrument soft stop
US10285695B2 (en) 2013-03-01 2019-05-14 Ethicon Llc Articulatable surgical instruments with conductive pathways
US9289452B2 (en) 2013-03-07 2016-03-22 Allosource Consistent calcium content bone allograft systems and methods
US9486556B2 (en) 2013-03-07 2016-11-08 Allosource Consistent calcium content bone allograft systems and methods
US10893867B2 (en) 2013-03-14 2021-01-19 Ethicon Llc Drive train control arrangements for modular surgical instruments
US11266406B2 (en) 2013-03-14 2022-03-08 Cilag Gmbh International Control systems for surgical instruments
US10617416B2 (en) 2013-03-14 2020-04-14 Ethicon Llc Control systems for surgical instruments
US11229725B2 (en) 2013-03-15 2022-01-25 Allosource Cell repopulated collagen matrix for soft tissue repair and regeneration
US9603710B2 (en) 2013-03-15 2017-03-28 Allosource Methods of manufacturing perforated osteochondral allograft compositions
US11395652B2 (en) 2013-04-16 2022-07-26 Cilag Gmbh International Powered surgical stapler
US11638581B2 (en) 2013-04-16 2023-05-02 Cilag Gmbh International Powered surgical stapler
US10702266B2 (en) 2013-04-16 2020-07-07 Ethicon Llc Surgical instrument system
US10888318B2 (en) 2013-04-16 2021-01-12 Ethicon Llc Powered surgical stapler
US11564679B2 (en) 2013-04-16 2023-01-31 Cilag Gmbh International Powered surgical stapler
US11406381B2 (en) 2013-04-16 2022-08-09 Cilag Gmbh International Powered surgical stapler
US11690615B2 (en) 2013-04-16 2023-07-04 Cilag Gmbh International Surgical system including an electric motor and a surgical instrument
US11622763B2 (en) 2013-04-16 2023-04-11 Cilag Gmbh International Stapling assembly comprising a shiftable drive
US11633183B2 (en) 2013-04-16 2023-04-25 Cilag International GmbH Stapling assembly comprising a retraction drive
US11133106B2 (en) 2013-08-23 2021-09-28 Cilag Gmbh International Surgical instrument assembly comprising a retraction assembly
US11701110B2 (en) 2013-08-23 2023-07-18 Cilag Gmbh International Surgical instrument including a drive assembly movable in a non-motorized mode of operation
US10828032B2 (en) 2013-08-23 2020-11-10 Ethicon Llc End effector detection systems for surgical instruments
US11376001B2 (en) 2013-08-23 2022-07-05 Cilag Gmbh International Surgical stapling device with rotary multi-turn retraction mechanism
US10441281B2 (en) 2013-08-23 2019-10-15 Ethicon Llc surgical instrument including securing and aligning features
US10898190B2 (en) 2013-08-23 2021-01-26 Ethicon Llc Secondary battery arrangements for powered surgical instruments
US11026680B2 (en) 2013-08-23 2021-06-08 Cilag Gmbh International Surgical instrument configured to operate in different states
US11918209B2 (en) 2013-08-23 2024-03-05 Cilag Gmbh International Torque optimization for surgical instruments
US11389160B2 (en) 2013-08-23 2022-07-19 Cilag Gmbh International Surgical system comprising a display
US10869665B2 (en) 2013-08-23 2020-12-22 Ethicon Llc Surgical instrument system including a control system
US11109858B2 (en) 2013-08-23 2021-09-07 Cilag Gmbh International Surgical instrument including a display which displays the position of a firing element
US11504119B2 (en) 2013-08-23 2022-11-22 Cilag Gmbh International Surgical instrument including an electronic firing lockout
US11000274B2 (en) 2013-08-23 2021-05-11 Ethicon Llc Powered surgical instrument
US11134940B2 (en) 2013-08-23 2021-10-05 Cilag Gmbh International Surgical instrument including a variable speed firing member
US11020115B2 (en) 2014-02-12 2021-06-01 Cilag Gmbh International Deliverable surgical instrument
US10426481B2 (en) 2014-02-24 2019-10-01 Ethicon Llc Implantable layer assemblies
US11497488B2 (en) 2014-03-26 2022-11-15 Cilag Gmbh International Systems and methods for controlling a segmented circuit
US10863981B2 (en) 2014-03-26 2020-12-15 Ethicon Llc Interface systems for use with surgical instruments
US10588626B2 (en) 2014-03-26 2020-03-17 Ethicon Llc Surgical instrument displaying subsequent step of use
US11259799B2 (en) 2014-03-26 2022-03-01 Cilag Gmbh International Interface systems for use with surgical instruments
US10898185B2 (en) 2014-03-26 2021-01-26 Ethicon Llc Surgical instrument power management through sleep and wake up control
US11517315B2 (en) 2014-04-16 2022-12-06 Cilag Gmbh International Fastener cartridges including extensions having different configurations
US10299792B2 (en) 2014-04-16 2019-05-28 Ethicon Llc Fastener cartridge comprising non-uniform fasteners
US11298134B2 (en) 2014-04-16 2022-04-12 Cilag Gmbh International Fastener cartridge comprising non-uniform fasteners
US11918222B2 (en) 2014-04-16 2024-03-05 Cilag Gmbh International Stapling assembly having firing member viewing windows
US11883026B2 (en) 2014-04-16 2024-01-30 Cilag Gmbh International Fastener cartridge assemblies and staple retainer cover arrangements
US10327776B2 (en) 2014-04-16 2019-06-25 Ethicon Llc Surgical stapling buttresses and adjunct materials
US11717294B2 (en) 2014-04-16 2023-08-08 Cilag Gmbh International End effector arrangements comprising indicators
US11382625B2 (en) 2014-04-16 2022-07-12 Cilag Gmbh International Fastener cartridge comprising non-uniform fasteners
US11266409B2 (en) 2014-04-16 2022-03-08 Cilag Gmbh International Fastener cartridge comprising a sled including longitudinally-staggered ramps
US10561422B2 (en) 2014-04-16 2020-02-18 Ethicon Llc Fastener cartridge comprising deployable tissue engaging members
US11596406B2 (en) 2014-04-16 2023-03-07 Cilag Gmbh International Fastener cartridges including extensions having different configurations
US11925353B2 (en) 2014-04-16 2024-03-12 Cilag Gmbh International Surgical stapling instrument comprising internal passage between stapling cartridge and elongate channel
US11382627B2 (en) 2014-04-16 2022-07-12 Cilag Gmbh International Surgical stapling assembly comprising a firing member including a lateral extension
US9730796B2 (en) 2014-05-16 2017-08-15 Allosource Composite bone constructs and methods
US10617526B2 (en) 2014-05-16 2020-04-14 Allosource Composite bone constructs and methods
US11653918B2 (en) 2014-09-05 2023-05-23 Cilag Gmbh International Local display of tissue parameter stabilization
US11717297B2 (en) 2014-09-05 2023-08-08 Cilag Gmbh International Smart cartridge wake up operation and data retention
US11311294B2 (en) 2014-09-05 2022-04-26 Cilag Gmbh International Powered medical device including measurement of closure state of jaws
US10905423B2 (en) 2014-09-05 2021-02-02 Ethicon Llc Smart cartridge wake up operation and data retention
US11076854B2 (en) 2014-09-05 2021-08-03 Cilag Gmbh International Smart cartridge wake up operation and data retention
US11406386B2 (en) 2014-09-05 2022-08-09 Cilag Gmbh International End effector including magnetic and impedance sensors
US11071545B2 (en) 2014-09-05 2021-07-27 Cilag Gmbh International Smart cartridge wake up operation and data retention
US11389162B2 (en) 2014-09-05 2022-07-19 Cilag Gmbh International Smart cartridge wake up operation and data retention
US11284898B2 (en) 2014-09-18 2022-03-29 Cilag Gmbh International Surgical instrument including a deployable knife
US20210077661A1 (en) * 2014-09-25 2021-03-18 Acell, Inc. Porous foams derived from extracellular matrix, porous foam ecm medical devices, and methods of use and making thereof
US20160089477A1 (en) * 2014-09-25 2016-03-31 Acell, Inc. Porous foams derived from extracellular matrix, porous foam ecm medical devices, and methods of use and making thereof
CN107073172A (en) * 2014-09-25 2017-08-18 阿塞尔公司 Porous foam derived from extracellular matrix, porous foam ECM medical treatment devices and its application method and manufacture method
US10426477B2 (en) 2014-09-26 2019-10-01 Ethicon Llc Staple cartridge assembly including a ramp
US10751053B2 (en) 2014-09-26 2020-08-25 Ethicon Llc Fastener cartridges for applying expandable fastener lines
US11202633B2 (en) 2014-09-26 2021-12-21 Cilag Gmbh International Surgical stapling buttresses and adjunct materials
US10327764B2 (en) 2014-09-26 2019-06-25 Ethicon Llc Method for creating a flexible staple line
US11523821B2 (en) 2014-09-26 2022-12-13 Cilag Gmbh International Method for creating a flexible staple line
US10736630B2 (en) 2014-10-13 2020-08-11 Ethicon Llc Staple cartridge
US10071182B2 (en) 2014-10-14 2018-09-11 Samuel E. Lynch Methods for treating wounds
US11701114B2 (en) 2014-10-16 2023-07-18 Cilag Gmbh International Staple cartridge
US11918210B2 (en) 2014-10-16 2024-03-05 Cilag Gmbh International Staple cartridge comprising a cartridge body including a plurality of wells
US10905418B2 (en) 2014-10-16 2021-02-02 Ethicon Llc Staple cartridge comprising a tissue thickness compensator
US11185325B2 (en) 2014-10-16 2021-11-30 Cilag Gmbh International End effector including different tissue gaps
US11864760B2 (en) 2014-10-29 2024-01-09 Cilag Gmbh International Staple cartridges comprising driver arrangements
US11141153B2 (en) 2014-10-29 2021-10-12 Cilag Gmbh International Staple cartridges comprising driver arrangements
US11241229B2 (en) 2014-10-29 2022-02-08 Cilag Gmbh International Staple cartridges comprising driver arrangements
US11457918B2 (en) 2014-10-29 2022-10-04 Cilag Gmbh International Cartridge assemblies for surgical staplers
US11337698B2 (en) 2014-11-06 2022-05-24 Cilag Gmbh International Staple cartridge comprising a releasable adjunct material
US10617417B2 (en) 2014-11-06 2020-04-14 Ethicon Llc Staple cartridge comprising a releasable adjunct material
US11382628B2 (en) 2014-12-10 2022-07-12 Cilag Gmbh International Articulatable surgical instrument system
US10736636B2 (en) 2014-12-10 2020-08-11 Ethicon Llc Articulatable surgical instrument system
US11399831B2 (en) 2014-12-18 2022-08-02 Cilag Gmbh International Drive arrangements for articulatable surgical instruments
US10743873B2 (en) 2014-12-18 2020-08-18 Ethicon Llc Drive arrangements for articulatable surgical instruments
US11547404B2 (en) 2014-12-18 2023-01-10 Cilag Gmbh International Surgical instrument assembly comprising a flexible articulation system
US11812958B2 (en) 2014-12-18 2023-11-14 Cilag Gmbh International Locking arrangements for detachable shaft assemblies with articulatable surgical end effectors
US11678877B2 (en) 2014-12-18 2023-06-20 Cilag Gmbh International Surgical instrument including a flexible support configured to support a flexible firing member
US11553911B2 (en) 2014-12-18 2023-01-17 Cilag Gmbh International Surgical instrument assembly comprising a flexible articulation system
US10695058B2 (en) 2014-12-18 2020-06-30 Ethicon Llc Surgical instrument systems comprising an articulatable end effector and means for adjusting the firing stroke of a firing member
US11083453B2 (en) 2014-12-18 2021-08-10 Cilag Gmbh International Surgical stapling system including a flexible firing actuator and lateral buckling supports
US11571207B2 (en) 2014-12-18 2023-02-07 Cilag Gmbh International Surgical system including lateral supports for a flexible drive member
US11547403B2 (en) 2014-12-18 2023-01-10 Cilag Gmbh International Surgical instrument having a laminate firing actuator and lateral buckling supports
US11517311B2 (en) 2014-12-18 2022-12-06 Cilag Gmbh International Surgical instrument systems comprising an articulatable end effector and means for adjusting the firing stroke of a firing member
US10806448B2 (en) 2014-12-18 2020-10-20 Ethicon Llc Surgical instrument assembly comprising a flexible articulation system
US10945728B2 (en) 2014-12-18 2021-03-16 Ethicon Llc Locking arrangements for detachable shaft assemblies with articulatable surgical end effectors
US9238090B1 (en) 2014-12-24 2016-01-19 Fettech, Llc Tissue-based compositions
US11324506B2 (en) 2015-02-27 2022-05-10 Cilag Gmbh International Modular stapling assembly
US11744588B2 (en) 2015-02-27 2023-09-05 Cilag Gmbh International Surgical stapling instrument including a removably attachable battery pack
US11154301B2 (en) 2015-02-27 2021-10-26 Cilag Gmbh International Modular stapling assembly
US11426160B2 (en) 2015-03-06 2022-08-30 Cilag Gmbh International Smart sensors with local signal processing
US11350843B2 (en) 2015-03-06 2022-06-07 Cilag Gmbh International Time dependent evaluation of sensor data to determine stability, creep, and viscoelastic elements of measures
US10441279B2 (en) 2015-03-06 2019-10-15 Ethicon Llc Multiple level thresholds to modify operation of powered surgical instruments
US10524787B2 (en) 2015-03-06 2020-01-07 Ethicon Llc Powered surgical instrument with parameter-based firing rate
US10966627B2 (en) 2015-03-06 2021-04-06 Ethicon Llc Time dependent evaluation of sensor data to determine stability, creep, and viscoelastic elements of measures
US10531887B2 (en) 2015-03-06 2020-01-14 Ethicon Llc Powered surgical instrument including speed display
US10617412B2 (en) 2015-03-06 2020-04-14 Ethicon Llc System for detecting the mis-insertion of a staple cartridge into a surgical stapler
US11224423B2 (en) 2015-03-06 2022-01-18 Cilag Gmbh International Smart sensors with local signal processing
US11109859B2 (en) 2015-03-06 2021-09-07 Cilag Gmbh International Surgical instrument comprising a lockable battery housing
US10548504B2 (en) 2015-03-06 2020-02-04 Ethicon Llc Overlaid multi sensor radio frequency (RF) electrode system to measure tissue compression
US10772625B2 (en) 2015-03-06 2020-09-15 Ethicon Llc Signal and power communication system positioned on a rotatable shaft
US10687806B2 (en) 2015-03-06 2020-06-23 Ethicon Llc Adaptive tissue compression techniques to adjust closure rates for multiple tissue types
US11826132B2 (en) 2015-03-06 2023-11-28 Cilag Gmbh International Time dependent evaluation of sensor data to determine stability, creep, and viscoelastic elements of measures
US11918212B2 (en) 2015-03-31 2024-03-05 Cilag Gmbh International Surgical instrument with selectively disengageable drive systems
US10433844B2 (en) 2015-03-31 2019-10-08 Ethicon Llc Surgical instrument with selectively disengageable threaded drive systems
US10617418B2 (en) 2015-08-17 2020-04-14 Ethicon Llc Implantable layers for a surgical instrument
US11058425B2 (en) 2015-08-17 2021-07-13 Ethicon Llc Implantable layers for a surgical instrument
US11052175B2 (en) 2015-08-19 2021-07-06 Musculoskeletal Transplant Foundation Cartilage-derived implants and methods of making and using same
US11806443B2 (en) 2015-08-19 2023-11-07 Musculoskeletal Transplant Foundation Cartilage-derived implants and methods of making and using same
US11490889B2 (en) 2015-09-23 2022-11-08 Cilag Gmbh International Surgical stapler having motor control based on an electrical parameter related to a motor current
US10863986B2 (en) 2015-09-23 2020-12-15 Ethicon Llc Surgical stapler having downstream current-based motor control
US11849946B2 (en) 2015-09-23 2023-12-26 Cilag Gmbh International Surgical stapler having downstream current-based motor control
US10327769B2 (en) 2015-09-23 2019-06-25 Ethicon Llc Surgical stapler having motor control based on a drive system component
US11344299B2 (en) 2015-09-23 2022-05-31 Cilag Gmbh International Surgical stapler having downstream current-based motor control
US11026678B2 (en) 2015-09-23 2021-06-08 Cilag Gmbh International Surgical stapler having motor control based on an electrical parameter related to a motor current
US11076929B2 (en) 2015-09-25 2021-08-03 Cilag Gmbh International Implantable adjunct systems for determining adjunct skew
US10299878B2 (en) 2015-09-25 2019-05-28 Ethicon Llc Implantable adjunct systems for determining adjunct skew
US10433846B2 (en) 2015-09-30 2019-10-08 Ethicon Llc Compressible adjunct with crossing spacer fibers
US10932779B2 (en) 2015-09-30 2021-03-02 Ethicon Llc Compressible adjunct with crossing spacer fibers
US11793522B2 (en) 2015-09-30 2023-10-24 Cilag Gmbh International Staple cartridge assembly including a compressible adjunct
US10285699B2 (en) 2015-09-30 2019-05-14 Ethicon Llc Compressible adjunct
US11903586B2 (en) 2015-09-30 2024-02-20 Cilag Gmbh International Compressible adjunct with crossing spacer fibers
US10478188B2 (en) 2015-09-30 2019-11-19 Ethicon Llc Implantable layer comprising a constricted configuration
US10980539B2 (en) 2015-09-30 2021-04-20 Ethicon Llc Implantable adjunct comprising bonded layers
US11890015B2 (en) 2015-09-30 2024-02-06 Cilag Gmbh International Compressible adjunct with crossing spacer fibers
US10271849B2 (en) 2015-09-30 2019-04-30 Ethicon Llc Woven constructs with interlocked standing fibers
US10561420B2 (en) 2015-09-30 2020-02-18 Ethicon Llc Tubular absorbable constructs
US10603039B2 (en) 2015-09-30 2020-03-31 Ethicon Llc Progressively releasable implantable adjunct for use with a surgical stapling instrument
US10307160B2 (en) 2015-09-30 2019-06-04 Ethicon Llc Compressible adjunct assemblies with attachment layers
US11690623B2 (en) 2015-09-30 2023-07-04 Cilag Gmbh International Method for applying an implantable layer to a fastener cartridge
US10736633B2 (en) 2015-09-30 2020-08-11 Ethicon Llc Compressible adjunct with looping members
US11553916B2 (en) 2015-09-30 2023-01-17 Cilag Gmbh International Compressible adjunct with crossing spacer fibers
US11712244B2 (en) 2015-09-30 2023-08-01 Cilag Gmbh International Implantable layer with spacer fibers
US10327777B2 (en) 2015-09-30 2019-06-25 Ethicon Llc Implantable layer comprising plastically deformed fibers
US10524788B2 (en) 2015-09-30 2020-01-07 Ethicon Llc Compressible adjunct with attachment regions
US11759208B2 (en) 2015-12-30 2023-09-19 Cilag Gmbh International Mechanisms for compensating for battery pack failure in powered surgical instruments
US10292704B2 (en) 2015-12-30 2019-05-21 Ethicon Llc Mechanisms for compensating for battery pack failure in powered surgical instruments
US11083454B2 (en) 2015-12-30 2021-08-10 Cilag Gmbh International Mechanisms for compensating for drivetrain failure in powered surgical instruments
US11484309B2 (en) 2015-12-30 2022-11-01 Cilag Gmbh International Surgical stapling system comprising a controller configured to cause a motor to reset a firing sequence
US10368865B2 (en) 2015-12-30 2019-08-06 Ethicon Llc Mechanisms for compensating for drivetrain failure in powered surgical instruments
US11058422B2 (en) 2015-12-30 2021-07-13 Cilag Gmbh International Mechanisms for compensating for battery pack failure in powered surgical instruments
US11129613B2 (en) 2015-12-30 2021-09-28 Cilag Gmbh International Surgical instruments with separable motors and motor control circuits
US10433837B2 (en) 2016-02-09 2019-10-08 Ethicon Llc Surgical instruments with multiple link articulation arrangements
US11730471B2 (en) 2016-02-09 2023-08-22 Cilag Gmbh International Articulatable surgical instruments with single articulation link arrangements
US11213293B2 (en) 2016-02-09 2022-01-04 Cilag Gmbh International Articulatable surgical instruments with single articulation link arrangements
US10588625B2 (en) 2016-02-09 2020-03-17 Ethicon Llc Articulatable surgical instruments with off-axis firing beam arrangements
US11523823B2 (en) 2016-02-09 2022-12-13 Cilag Gmbh International Surgical instruments with non-symmetrical articulation arrangements
US10413291B2 (en) 2016-02-09 2019-09-17 Ethicon Llc Surgical instrument articulation mechanism with slotted secondary constraint
US10653413B2 (en) 2016-02-09 2020-05-19 Ethicon Llc Surgical instruments with an end effector that is highly articulatable relative to an elongate shaft assembly
US11344303B2 (en) 2016-02-12 2022-05-31 Cilag Gmbh International Mechanisms for compensating for drivetrain failure in powered surgical instruments
US11224426B2 (en) 2016-02-12 2022-01-18 Cilag Gmbh International Mechanisms for compensating for drivetrain failure in powered surgical instruments
US11826045B2 (en) 2016-02-12 2023-11-28 Cilag Gmbh International Mechanisms for compensating for drivetrain failure in powered surgical instruments
US11779336B2 (en) 2016-02-12 2023-10-10 Cilag Gmbh International Mechanisms for compensating for drivetrain failure in powered surgical instruments
US10376263B2 (en) 2016-04-01 2019-08-13 Ethicon Llc Anvil modification members for surgical staplers
US10617413B2 (en) 2016-04-01 2020-04-14 Ethicon Llc Closure system arrangements for surgical cutting and stapling devices with separate and distinct firing shafts
US10492783B2 (en) 2016-04-15 2019-12-03 Ethicon, Llc Surgical instrument with improved stop/start control during a firing motion
US11026684B2 (en) 2016-04-15 2021-06-08 Ethicon Llc Surgical instrument with multiple program responses during a firing motion
US11642125B2 (en) 2016-04-15 2023-05-09 Cilag Gmbh International Robotic surgical system including a user interface and a control circuit
US10357247B2 (en) 2016-04-15 2019-07-23 Ethicon Llc Surgical instrument with multiple program responses during a firing motion
US11051810B2 (en) 2016-04-15 2021-07-06 Cilag Gmbh International Modular surgical instrument with configurable operating mode
US11284891B2 (en) 2016-04-15 2022-03-29 Cilag Gmbh International Surgical instrument with multiple program responses during a firing motion
US11179150B2 (en) 2016-04-15 2021-11-23 Cilag Gmbh International Systems and methods for controlling a surgical stapling and cutting instrument
US11350932B2 (en) 2016-04-15 2022-06-07 Cilag Gmbh International Surgical instrument with improved stop/start control during a firing motion
US10335145B2 (en) 2016-04-15 2019-07-02 Ethicon Llc Modular surgical instrument with configurable operating mode
US11191545B2 (en) 2016-04-15 2021-12-07 Cilag Gmbh International Staple formation detection mechanisms
US10405859B2 (en) 2016-04-15 2019-09-10 Ethicon Llc Surgical instrument with adjustable stop/start control during a firing motion
US10426467B2 (en) 2016-04-15 2019-10-01 Ethicon Llc Surgical instrument with detection sensors
US10828028B2 (en) 2016-04-15 2020-11-10 Ethicon Llc Surgical instrument with multiple program responses during a firing motion
US11317910B2 (en) 2016-04-15 2022-05-03 Cilag Gmbh International Surgical instrument with detection sensors
US11771454B2 (en) 2016-04-15 2023-10-03 Cilag Gmbh International Stapling assembly including a controller for monitoring a clamping laod
US10456137B2 (en) 2016-04-15 2019-10-29 Ethicon Llc Staple formation detection mechanisms
US11517306B2 (en) 2016-04-15 2022-12-06 Cilag Gmbh International Surgical instrument with detection sensors
US11311292B2 (en) 2016-04-15 2022-04-26 Cilag Gmbh International Surgical instrument with detection sensors
US11607239B2 (en) 2016-04-15 2023-03-21 Cilag Gmbh International Systems and methods for controlling a surgical stapling and cutting instrument
US11147554B2 (en) 2016-04-18 2021-10-19 Cilag Gmbh International Surgical instrument system comprising a magnetic lockout
US10478181B2 (en) 2016-04-18 2019-11-19 Ethicon Llc Cartridge lockout arrangements for rotary powered surgical cutting and stapling instruments
US11811253B2 (en) 2016-04-18 2023-11-07 Cilag Gmbh International Surgical robotic system with fault state detection configurations based on motor current draw
US10433840B2 (en) 2016-04-18 2019-10-08 Ethicon Llc Surgical instrument comprising a replaceable cartridge jaw
US10368867B2 (en) 2016-04-18 2019-08-06 Ethicon Llc Surgical instrument comprising a lockout
US11317917B2 (en) 2016-04-18 2022-05-03 Cilag Gmbh International Surgical stapling system comprising a lockable firing assembly
US10363037B2 (en) 2016-04-18 2019-07-30 Ethicon Llc Surgical instrument system comprising a magnetic lockout
US11350928B2 (en) 2016-04-18 2022-06-07 Cilag Gmbh International Surgical instrument comprising a tissue thickness lockout and speed control system
US11559303B2 (en) 2016-04-18 2023-01-24 Cilag Gmbh International Cartridge lockout arrangements for rotary powered surgical cutting and stapling instruments
US10426469B2 (en) 2016-04-18 2019-10-01 Ethicon Llc Surgical instrument comprising a primary firing lockout and a secondary firing lockout
US10639034B2 (en) 2016-12-21 2020-05-05 Ethicon Llc Surgical instruments with lockout arrangements for preventing firing system actuation unless an unspent staple cartridge is present
US10881401B2 (en) 2016-12-21 2021-01-05 Ethicon Llc Staple firing member comprising a missing cartridge and/or spent cartridge lockout
US10893864B2 (en) 2016-12-21 2021-01-19 Ethicon Staple cartridges and arrangements of staples and staple cavities therein
US10499914B2 (en) 2016-12-21 2019-12-10 Ethicon Llc Staple forming pocket arrangements
US11224428B2 (en) 2016-12-21 2022-01-18 Cilag Gmbh International Surgical stapling systems
US11766259B2 (en) 2016-12-21 2023-09-26 Cilag Gmbh International Method of deforming staples from two different types of staple cartridges with the same surgical stapling instrument
US11350934B2 (en) 2016-12-21 2022-06-07 Cilag Gmbh International Staple forming pocket arrangement to accommodate different types of staples
US11317913B2 (en) 2016-12-21 2022-05-03 Cilag Gmbh International Lockout arrangements for surgical end effectors and replaceable tool assemblies
US10779823B2 (en) 2016-12-21 2020-09-22 Ethicon Llc Firing member pin angle
US10426471B2 (en) 2016-12-21 2019-10-01 Ethicon Llc Surgical instrument with multiple failure response modes
US11350935B2 (en) 2016-12-21 2022-06-07 Cilag Gmbh International Surgical tool assemblies with closure stroke reduction features
US10898186B2 (en) 2016-12-21 2021-01-26 Ethicon Llc Staple forming pocket arrangements comprising primary sidewalls and pocket sidewalls
US10617414B2 (en) 2016-12-21 2020-04-14 Ethicon Llc Closure member arrangements for surgical instruments
US11766260B2 (en) 2016-12-21 2023-09-26 Cilag Gmbh International Methods of stapling tissue
US10517595B2 (en) 2016-12-21 2019-12-31 Ethicon Llc Jaw actuated lock arrangements for preventing advancement of a firing member in a surgical end effector unless an unfired cartridge is installed in the end effector
US10736629B2 (en) 2016-12-21 2020-08-11 Ethicon Llc Surgical tool assemblies with clutching arrangements for shifting between closure systems with closure stroke reduction features and articulation and firing systems
US11369376B2 (en) 2016-12-21 2022-06-28 Cilag Gmbh International Surgical stapling systems
US10610224B2 (en) 2016-12-21 2020-04-07 Ethicon Llc Lockout arrangements for surgical end effectors and replaceable tool assemblies
US11090048B2 (en) 2016-12-21 2021-08-17 Cilag Gmbh International Method for resetting a fuse of a surgical instrument shaft
US10568625B2 (en) 2016-12-21 2020-02-25 Ethicon Llc Staple cartridges and arrangements of staples and staple cavities therein
US10758229B2 (en) 2016-12-21 2020-09-01 Ethicon Llc Surgical instrument comprising improved jaw control
US10888322B2 (en) 2016-12-21 2021-01-12 Ethicon Llc Surgical instrument comprising a cutting member
US10624635B2 (en) 2016-12-21 2020-04-21 Ethicon Llc Firing members with non-parallel jaw engagement features for surgical end effectors
US10758230B2 (en) 2016-12-21 2020-09-01 Ethicon Llc Surgical instrument with primary and safety processors
US10856868B2 (en) 2016-12-21 2020-12-08 Ethicon Llc Firing member pin configurations
US11096689B2 (en) 2016-12-21 2021-08-24 Cilag Gmbh International Shaft assembly comprising a lockout
US10588631B2 (en) 2016-12-21 2020-03-17 Ethicon Llc Surgical instruments with positive jaw opening features
US10517596B2 (en) 2016-12-21 2019-12-31 Ethicon Llc Articulatable surgical instruments with articulation stroke amplification features
US10639035B2 (en) 2016-12-21 2020-05-05 Ethicon Llc Surgical stapling instruments and replaceable tool assemblies thereof
US10568624B2 (en) 2016-12-21 2020-02-25 Ethicon Llc Surgical instruments with jaws that are pivotable about a fixed axis and include separate and distinct closure and firing systems
US11918215B2 (en) 2016-12-21 2024-03-05 Cilag Gmbh International Staple cartridge with array of staple pockets
US10568626B2 (en) 2016-12-21 2020-02-25 Ethicon Llc Surgical instruments with jaw opening features for increasing a jaw opening distance
US10905422B2 (en) 2016-12-21 2021-02-02 Ethicon Llc Surgical instrument for use with a robotic surgical system
US11571210B2 (en) 2016-12-21 2023-02-07 Cilag Gmbh International Firing assembly comprising a multiple failed-state fuse
US11134942B2 (en) 2016-12-21 2021-10-05 Cilag Gmbh International Surgical stapling instruments and staple-forming anvils
US11191543B2 (en) 2016-12-21 2021-12-07 Cilag Gmbh International Assembly comprising a lock
US11653917B2 (en) 2016-12-21 2023-05-23 Cilag Gmbh International Surgical stapling systems
US10835247B2 (en) 2016-12-21 2020-11-17 Ethicon Llc Lockout arrangements for surgical end effectors
US11419606B2 (en) 2016-12-21 2022-08-23 Cilag Gmbh International Shaft assembly comprising a clutch configured to adapt the output of a rotary firing member to two different systems
US10835245B2 (en) 2016-12-21 2020-11-17 Ethicon Llc Method for attaching a shaft assembly to a surgical instrument and, alternatively, to a surgical robot
US11191540B2 (en) 2016-12-21 2021-12-07 Cilag Gmbh International Protective cover arrangements for a joint interface between a movable jaw and actuator shaft of a surgical instrument
US11191539B2 (en) 2016-12-21 2021-12-07 Cilag Gmbh International Shaft assembly comprising a manually-operable retraction system for use with a motorized surgical instrument system
US10485543B2 (en) 2016-12-21 2019-11-26 Ethicon Llc Anvil having a knife slot width
US10980536B2 (en) 2016-12-21 2021-04-20 Ethicon Llc No-cartridge and spent cartridge lockout arrangements for surgical staplers
US10588630B2 (en) 2016-12-21 2020-03-17 Ethicon Llc Surgical tool assemblies with closure stroke reduction features
US10603036B2 (en) 2016-12-21 2020-03-31 Ethicon Llc Articulatable surgical instrument with independent pivotable linkage distal of an articulation lock
US10973516B2 (en) 2016-12-21 2021-04-13 Ethicon Llc Surgical end effectors and adaptable firing members therefor
US10492785B2 (en) 2016-12-21 2019-12-03 Ethicon Llc Shaft assembly comprising a lockout
US10667810B2 (en) 2016-12-21 2020-06-02 Ethicon Llc Closure members with cam surface arrangements for surgical instruments with separate and distinct closure and firing systems
US10918385B2 (en) 2016-12-21 2021-02-16 Ethicon Llc Surgical system comprising a firing member rotatable into an articulation state to articulate an end effector of the surgical system
US10582928B2 (en) 2016-12-21 2020-03-10 Ethicon Llc Articulation lock arrangements for locking an end effector in an articulated position in response to actuation of a jaw closure system
US10524789B2 (en) 2016-12-21 2020-01-07 Ethicon Llc Laterally actuatable articulation lock arrangements for locking an end effector of a surgical instrument in an articulated configuration
US10959727B2 (en) 2016-12-21 2021-03-30 Ethicon Llc Articulatable surgical end effector with asymmetric shaft arrangement
US10667811B2 (en) 2016-12-21 2020-06-02 Ethicon Llc Surgical stapling instruments and staple-forming anvils
US10667809B2 (en) 2016-12-21 2020-06-02 Ethicon Llc Staple cartridge and staple cartridge channel comprising windows defined therein
US10675026B2 (en) 2016-12-21 2020-06-09 Ethicon Llc Methods of stapling tissue
US11564688B2 (en) 2016-12-21 2023-01-31 Cilag Gmbh International Robotic surgical tool having a retraction mechanism
US11701115B2 (en) 2016-12-21 2023-07-18 Cilag Gmbh International Methods of stapling tissue
US10813638B2 (en) 2016-12-21 2020-10-27 Ethicon Llc Surgical end effectors with expandable tissue stop arrangements
US10695055B2 (en) 2016-12-21 2020-06-30 Ethicon Llc Firing assembly comprising a lockout
US11179155B2 (en) 2016-12-21 2021-11-23 Cilag Gmbh International Anvil arrangements for surgical staplers
US10542982B2 (en) 2016-12-21 2020-01-28 Ethicon Llc Shaft assembly comprising first and second articulation lockouts
US10588632B2 (en) 2016-12-21 2020-03-17 Ethicon Llc Surgical end effectors and firing members thereof
US10537325B2 (en) 2016-12-21 2020-01-21 Ethicon Llc Staple forming pocket arrangement to accommodate different types of staples
US10448950B2 (en) 2016-12-21 2019-10-22 Ethicon Llc Surgical staplers with independently actuatable closing and firing systems
US10687809B2 (en) 2016-12-21 2020-06-23 Ethicon Llc Surgical staple cartridge with movable camming member configured to disengage firing member lockout features
US10675025B2 (en) 2016-12-21 2020-06-09 Ethicon Llc Shaft assembly comprising separately actuatable and retractable systems
US11160551B2 (en) 2016-12-21 2021-11-02 Cilag Gmbh International Articulatable surgical stapling instruments
US11497499B2 (en) 2016-12-21 2022-11-15 Cilag Gmbh International Articulatable surgical stapling instruments
US10682138B2 (en) 2016-12-21 2020-06-16 Ethicon Llc Bilaterally asymmetric staple forming pocket pairs
US11160553B2 (en) 2016-12-21 2021-11-02 Cilag Gmbh International Surgical stapling systems
US11849948B2 (en) 2016-12-21 2023-12-26 Cilag Gmbh International Method for resetting a fuse of a surgical instrument shaft
US11871939B2 (en) 2017-06-20 2024-01-16 Cilag Gmbh International Method for closed loop control of motor velocity of a surgical stapling and cutting instrument
US11213302B2 (en) 2017-06-20 2022-01-04 Cilag Gmbh International Method for closed loop control of motor velocity of a surgical stapling and cutting instrument
US10779820B2 (en) 2017-06-20 2020-09-22 Ethicon Llc Systems and methods for controlling motor speed according to user input for a surgical instrument
US10881396B2 (en) 2017-06-20 2021-01-05 Ethicon Llc Surgical instrument with variable duration trigger arrangement
US10368864B2 (en) 2017-06-20 2019-08-06 Ethicon Llc Systems and methods for controlling displaying motor velocity for a surgical instrument
US10888321B2 (en) 2017-06-20 2021-01-12 Ethicon Llc Systems and methods for controlling velocity of a displacement member of a surgical stapling and cutting instrument
US11517325B2 (en) 2017-06-20 2022-12-06 Cilag Gmbh International Closed loop feedback control of motor velocity of a surgical stapling and cutting instrument based on measured displacement distance traveled over a specified time interval
US10327767B2 (en) 2017-06-20 2019-06-25 Ethicon Llc Control of motor velocity of a surgical stapling and cutting instrument based on angle of articulation
USD879808S1 (en) 2017-06-20 2020-03-31 Ethicon Llc Display panel with graphical user interface
US11793513B2 (en) 2017-06-20 2023-10-24 Cilag Gmbh International Systems and methods for controlling motor speed according to user input for a surgical instrument
US10813639B2 (en) 2017-06-20 2020-10-27 Ethicon Llc Closed loop feedback control of motor velocity of a surgical stapling and cutting instrument based on system conditions
US11071554B2 (en) 2017-06-20 2021-07-27 Cilag Gmbh International Closed loop feedback control of motor velocity of a surgical stapling and cutting instrument based on magnitude of velocity error measurements
US10881399B2 (en) 2017-06-20 2021-01-05 Ethicon Llc Techniques for adaptive control of motor velocity of a surgical stapling and cutting instrument
US10646220B2 (en) 2017-06-20 2020-05-12 Ethicon Llc Systems and methods for controlling displacement member velocity for a surgical instrument
US11653914B2 (en) 2017-06-20 2023-05-23 Cilag Gmbh International Systems and methods for controlling motor velocity of a surgical stapling and cutting instrument according to articulation angle of end effector
USD890784S1 (en) 2017-06-20 2020-07-21 Ethicon Llc Display panel with changeable graphical user interface
US10595882B2 (en) 2017-06-20 2020-03-24 Ethicon Llc Methods for closed loop control of motor velocity of a surgical stapling and cutting instrument
US11090046B2 (en) 2017-06-20 2021-08-17 Cilag Gmbh International Systems and methods for controlling displacement member motion of a surgical stapling and cutting instrument
US11382638B2 (en) 2017-06-20 2022-07-12 Cilag Gmbh International Closed loop feedback control of motor velocity of a surgical stapling and cutting instrument based on measured time over a specified displacement distance
US10624633B2 (en) 2017-06-20 2020-04-21 Ethicon Llc Systems and methods for controlling motor velocity of a surgical stapling and cutting instrument
US11672532B2 (en) 2017-06-20 2023-06-13 Cilag Gmbh International Techniques for adaptive control of motor velocity of a surgical stapling and cutting instrument
USD879809S1 (en) 2017-06-20 2020-03-31 Ethicon Llc Display panel with changeable graphical user interface
US10307170B2 (en) 2017-06-20 2019-06-04 Ethicon Llc Method for closed loop control of motor velocity of a surgical stapling and cutting instrument
US10980537B2 (en) 2017-06-20 2021-04-20 Ethicon Llc Closed loop feedback control of motor velocity of a surgical stapling and cutting instrument based on measured time over a specified number of shaft rotations
US10631859B2 (en) 2017-06-27 2020-04-28 Ethicon Llc Articulation systems for surgical instruments
US10993716B2 (en) 2017-06-27 2021-05-04 Ethicon Llc Surgical anvil arrangements
US11090049B2 (en) 2017-06-27 2021-08-17 Cilag Gmbh International Staple forming pocket arrangements
US11266405B2 (en) 2017-06-27 2022-03-08 Cilag Gmbh International Surgical anvil manufacturing methods
US11324503B2 (en) 2017-06-27 2022-05-10 Cilag Gmbh International Surgical firing member arrangements
US10772629B2 (en) 2017-06-27 2020-09-15 Ethicon Llc Surgical anvil arrangements
US11766258B2 (en) 2017-06-27 2023-09-26 Cilag Gmbh International Surgical anvil arrangements
US11141154B2 (en) 2017-06-27 2021-10-12 Cilag Gmbh International Surgical end effectors and anvils
US10856869B2 (en) 2017-06-27 2020-12-08 Ethicon Llc Surgical anvil arrangements
US11696759B2 (en) 2017-06-28 2023-07-11 Cilag Gmbh International Surgical stapling instruments comprising shortened staple cartridge noses
US11058424B2 (en) 2017-06-28 2021-07-13 Cilag Gmbh International Surgical instrument comprising an offset articulation joint
US10903685B2 (en) 2017-06-28 2021-01-26 Ethicon Llc Surgical shaft assemblies with slip ring assemblies forming capacitive channels
US10786253B2 (en) 2017-06-28 2020-09-29 Ethicon Llc Surgical end effectors with improved jaw aperture arrangements
US11826048B2 (en) 2017-06-28 2023-11-28 Cilag Gmbh International Surgical instrument comprising selectively actuatable rotatable couplers
US11564686B2 (en) 2017-06-28 2023-01-31 Cilag Gmbh International Surgical shaft assemblies with flexible interfaces
US10779824B2 (en) 2017-06-28 2020-09-22 Ethicon Llc Surgical instrument comprising an articulation system lockable by a closure system
USD869655S1 (en) 2017-06-28 2019-12-10 Ethicon Llc Surgical fastener cartridge
US11484310B2 (en) 2017-06-28 2022-11-01 Cilag Gmbh International Surgical instrument comprising a shaft including a closure tube profile
US10639037B2 (en) 2017-06-28 2020-05-05 Ethicon Llc Surgical instrument with axially movable closure member
USD906355S1 (en) 2017-06-28 2020-12-29 Ethicon Llc Display screen or portion thereof with a graphical user interface for a surgical instrument
US10588633B2 (en) 2017-06-28 2020-03-17 Ethicon Llc Surgical instruments with open and closable jaws and axially movable firing member that is initially parked in close proximity to the jaws prior to firing
US11389161B2 (en) 2017-06-28 2022-07-19 Cilag Gmbh International Surgical instrument comprising selectively actuatable rotatable couplers
USD854151S1 (en) 2017-06-28 2019-07-16 Ethicon Llc Surgical instrument shaft
US11000279B2 (en) 2017-06-28 2021-05-11 Ethicon Llc Surgical instrument comprising an articulation system ratio
US11246592B2 (en) 2017-06-28 2022-02-15 Cilag Gmbh International Surgical instrument comprising an articulation system lockable to a frame
US10758232B2 (en) 2017-06-28 2020-09-01 Ethicon Llc Surgical instrument with positive jaw opening features
US11259805B2 (en) 2017-06-28 2022-03-01 Cilag Gmbh International Surgical instrument comprising firing member supports
US11020114B2 (en) 2017-06-28 2021-06-01 Cilag Gmbh International Surgical instruments with articulatable end effector with axially shortened articulation joint configurations
US10765427B2 (en) 2017-06-28 2020-09-08 Ethicon Llc Method for articulating a surgical instrument
US11642128B2 (en) 2017-06-28 2023-05-09 Cilag Gmbh International Method for articulating a surgical instrument
US10695057B2 (en) 2017-06-28 2020-06-30 Ethicon Llc Surgical instrument lockout arrangement
US11678880B2 (en) 2017-06-28 2023-06-20 Cilag Gmbh International Surgical instrument comprising a shaft including a housing arrangement
US11529140B2 (en) 2017-06-28 2022-12-20 Cilag Gmbh International Surgical instrument lockout arrangement
US11083455B2 (en) 2017-06-28 2021-08-10 Cilag Gmbh International Surgical instrument comprising an articulation system ratio
US11478242B2 (en) 2017-06-28 2022-10-25 Cilag Gmbh International Jaw retainer arrangement for retaining a pivotable surgical instrument jaw in pivotable retaining engagement with a second surgical instrument jaw
US10716614B2 (en) 2017-06-28 2020-07-21 Ethicon Llc Surgical shaft assemblies with slip ring assemblies with increased contact pressure
US10932772B2 (en) 2017-06-29 2021-03-02 Ethicon Llc Methods for closed loop velocity control for robotic surgical instrument
US11007022B2 (en) 2017-06-29 2021-05-18 Ethicon Llc Closed loop velocity control techniques based on sensed tissue parameters for robotic surgical instrument
US10898183B2 (en) 2017-06-29 2021-01-26 Ethicon Llc Robotic surgical instrument with closed loop feedback techniques for advancement of closure member during firing
US11890005B2 (en) 2017-06-29 2024-02-06 Cilag Gmbh International Methods for closed loop velocity control for robotic surgical instrument
US10398434B2 (en) 2017-06-29 2019-09-03 Ethicon Llc Closed loop velocity control of closure member for robotic surgical instrument
US11452796B2 (en) 2017-06-30 2022-09-27 Allosource Cellular bone grafts, and methods of manufacture and use
US11304695B2 (en) 2017-08-03 2022-04-19 Cilag Gmbh International Surgical system shaft interconnection
US11471155B2 (en) 2017-08-03 2022-10-18 Cilag Gmbh International Surgical system bailout
US10729501B2 (en) 2017-09-29 2020-08-04 Ethicon Llc Systems and methods for language selection of a surgical instrument
US10743872B2 (en) 2017-09-29 2020-08-18 Ethicon Llc System and methods for controlling a display of a surgical instrument
US11399829B2 (en) 2017-09-29 2022-08-02 Cilag Gmbh International Systems and methods of initiating a power shutdown mode for a surgical instrument
USD917500S1 (en) 2017-09-29 2021-04-27 Ethicon Llc Display screen or portion thereof with graphical user interface
USD907648S1 (en) 2017-09-29 2021-01-12 Ethicon Llc Display screen or portion thereof with animated graphical user interface
USD907647S1 (en) 2017-09-29 2021-01-12 Ethicon Llc Display screen or portion thereof with animated graphical user interface
US10796471B2 (en) 2017-09-29 2020-10-06 Ethicon Llc Systems and methods of displaying a knife position for a surgical instrument
US10765429B2 (en) 2017-09-29 2020-09-08 Ethicon Llc Systems and methods for providing alerts according to the operational state of a surgical instrument
US11134944B2 (en) 2017-10-30 2021-10-05 Cilag Gmbh International Surgical stapler knife motion controls
US11090075B2 (en) 2017-10-30 2021-08-17 Cilag Gmbh International Articulation features for surgical end effector
US11478244B2 (en) 2017-10-31 2022-10-25 Cilag Gmbh International Cartridge body design with force reduction based on firing completion
US10842490B2 (en) 2017-10-31 2020-11-24 Ethicon Llc Cartridge body design with force reduction based on firing completion
US10779903B2 (en) 2017-10-31 2020-09-22 Ethicon Llc Positive shaft rotation lock activated by jaw closure
US10966718B2 (en) 2017-12-15 2021-04-06 Ethicon Llc Dynamic clamping assemblies with improved wear characteristics for use in connection with electromechanical surgical instruments
US10869666B2 (en) 2017-12-15 2020-12-22 Ethicon Llc Adapters with control systems for controlling multiple motors of an electromechanical surgical instrument
US10779825B2 (en) 2017-12-15 2020-09-22 Ethicon Llc Adapters with end effector position sensing and control arrangements for use in connection with electromechanical surgical instruments
US10743875B2 (en) 2017-12-15 2020-08-18 Ethicon Llc Surgical end effectors with jaw stiffener arrangements configured to permit monitoring of firing member
US11197670B2 (en) 2017-12-15 2021-12-14 Cilag Gmbh International Surgical end effectors with pivotal jaws configured to touch at their respective distal ends when fully closed
US10779826B2 (en) 2017-12-15 2020-09-22 Ethicon Llc Methods of operating surgical end effectors
US10687813B2 (en) 2017-12-15 2020-06-23 Ethicon Llc Adapters with firing stroke sensing arrangements for use in connection with electromechanical surgical instruments
US11071543B2 (en) 2017-12-15 2021-07-27 Cilag Gmbh International Surgical end effectors with clamping assemblies configured to increase jaw aperture ranges
US10828033B2 (en) 2017-12-15 2020-11-10 Ethicon Llc Handheld electromechanical surgical instruments with improved motor control arrangements for positioning components of an adapter coupled thereto
US11006955B2 (en) 2017-12-15 2021-05-18 Ethicon Llc End effectors with positive jaw opening features for use with adapters for electromechanical surgical instruments
US11896222B2 (en) 2017-12-15 2024-02-13 Cilag Gmbh International Methods of operating surgical end effectors
US10743874B2 (en) 2017-12-15 2020-08-18 Ethicon Llc Sealed adapters for use with electromechanical surgical instruments
US11033267B2 (en) 2017-12-15 2021-06-15 Ethicon Llc Systems and methods of controlling a clamping member firing rate of a surgical instrument
US10835330B2 (en) 2017-12-19 2020-11-17 Ethicon Llc Method for determining the position of a rotatable jaw of a surgical instrument attachment assembly
US11020112B2 (en) 2017-12-19 2021-06-01 Ethicon Llc Surgical tools configured for interchangeable use with different controller interfaces
US11045270B2 (en) 2017-12-19 2021-06-29 Cilag Gmbh International Robotic attachment comprising exterior drive actuator
US10729509B2 (en) 2017-12-19 2020-08-04 Ethicon Llc Surgical instrument comprising closure and firing locking mechanism
US11284953B2 (en) 2017-12-19 2022-03-29 Cilag Gmbh International Method for determining the position of a rotatable jaw of a surgical instrument attachment assembly
US10716565B2 (en) 2017-12-19 2020-07-21 Ethicon Llc Surgical instruments with dual articulation drivers
USD910847S1 (en) 2017-12-19 2021-02-16 Ethicon Llc Surgical instrument assembly
US11583274B2 (en) 2017-12-21 2023-02-21 Cilag Gmbh International Self-guiding stapling instrument
US10743868B2 (en) 2017-12-21 2020-08-18 Ethicon Llc Surgical instrument comprising a pivotable distal head
US11369368B2 (en) 2017-12-21 2022-06-28 Cilag Gmbh International Surgical instrument comprising synchronized drive systems
US11337691B2 (en) 2017-12-21 2022-05-24 Cilag Gmbh International Surgical instrument configured to determine firing path
US11311290B2 (en) 2017-12-21 2022-04-26 Cilag Gmbh International Surgical instrument comprising an end effector dampener
US11751867B2 (en) 2017-12-21 2023-09-12 Cilag Gmbh International Surgical instrument comprising sequenced systems
US11883019B2 (en) 2017-12-21 2024-01-30 Cilag Gmbh International Stapling instrument comprising a staple feeding system
US11576668B2 (en) 2017-12-21 2023-02-14 Cilag Gmbh International Staple instrument comprising a firing path display
US11364027B2 (en) 2017-12-21 2022-06-21 Cilag Gmbh International Surgical instrument comprising speed control
US11179152B2 (en) 2017-12-21 2021-11-23 Cilag Gmbh International Surgical instrument comprising a tissue grasping system
US11179151B2 (en) 2017-12-21 2021-11-23 Cilag Gmbh International Surgical instrument comprising a display
US10682134B2 (en) 2017-12-21 2020-06-16 Ethicon Llc Continuous use self-propelled stapling instrument
US11129680B2 (en) 2017-12-21 2021-09-28 Cilag Gmbh International Surgical instrument comprising a projector
US11849939B2 (en) 2017-12-21 2023-12-26 Cilag Gmbh International Continuous use self-propelled stapling instrument
US11076853B2 (en) 2017-12-21 2021-08-03 Cilag Gmbh International Systems and methods of displaying a knife position during transection for a surgical instrument
US11207065B2 (en) 2018-08-20 2021-12-28 Cilag Gmbh International Method for fabricating surgical stapler anvils
US10842492B2 (en) 2018-08-20 2020-11-24 Ethicon Llc Powered articulatable surgical instruments with clutching and locking arrangements for linking an articulation drive system to a firing drive system
USD914878S1 (en) 2018-08-20 2021-03-30 Ethicon Llc Surgical instrument anvil
US11291440B2 (en) 2018-08-20 2022-04-05 Cilag Gmbh International Method for operating a powered articulatable surgical instrument
US11045192B2 (en) 2018-08-20 2021-06-29 Cilag Gmbh International Fabricating techniques for surgical stapler anvils
US10856870B2 (en) 2018-08-20 2020-12-08 Ethicon Llc Switching arrangements for motor powered articulatable surgical instruments
US11083458B2 (en) 2018-08-20 2021-08-10 Cilag Gmbh International Powered surgical instruments with clutching arrangements to convert linear drive motions to rotary drive motions
US11253256B2 (en) 2018-08-20 2022-02-22 Cilag Gmbh International Articulatable motor powered surgical instruments with dedicated articulation motor arrangements
US11324501B2 (en) 2018-08-20 2022-05-10 Cilag Gmbh International Surgical stapling devices with improved closure members
US10912559B2 (en) 2018-08-20 2021-02-09 Ethicon Llc Reinforced deformable anvil tip for surgical stapler anvil
US11039834B2 (en) 2018-08-20 2021-06-22 Cilag Gmbh International Surgical stapler anvils with staple directing protrusions and tissue stability features
US10779821B2 (en) 2018-08-20 2020-09-22 Ethicon Llc Surgical stapler anvils with tissue stop features configured to avoid tissue pinch
US11931032B2 (en) 2018-12-28 2024-03-19 Cilag Gmbh International Surgical instrument with wireless communication between a control unit of a robotic system and remote sensor
US11147551B2 (en) 2019-03-25 2021-10-19 Cilag Gmbh International Firing drive arrangements for surgical systems
US11172929B2 (en) 2019-03-25 2021-11-16 Cilag Gmbh International Articulation drive arrangements for surgical systems
US11147553B2 (en) 2019-03-25 2021-10-19 Cilag Gmbh International Firing drive arrangements for surgical systems
US11696761B2 (en) 2019-03-25 2023-07-11 Cilag Gmbh International Firing drive arrangements for surgical systems
US11432816B2 (en) 2019-04-30 2022-09-06 Cilag Gmbh International Articulation pin for a surgical instrument
US11253254B2 (en) 2019-04-30 2022-02-22 Cilag Gmbh International Shaft rotation actuator on a surgical instrument
US11471157B2 (en) 2019-04-30 2022-10-18 Cilag Gmbh International Articulation control mapping for a surgical instrument
US11648009B2 (en) 2019-04-30 2023-05-16 Cilag Gmbh International Rotatable jaw tip for a surgical instrument
US11426251B2 (en) 2019-04-30 2022-08-30 Cilag Gmbh International Articulation directional lights on a surgical instrument
US11903581B2 (en) 2019-04-30 2024-02-20 Cilag Gmbh International Methods for stapling tissue using a surgical instrument
US11452528B2 (en) 2019-04-30 2022-09-27 Cilag Gmbh International Articulation actuators for a surgical instrument
US11246678B2 (en) 2019-06-28 2022-02-15 Cilag Gmbh International Surgical stapling system having a frangible RFID tag
US11229437B2 (en) 2019-06-28 2022-01-25 Cilag Gmbh International Method for authenticating the compatibility of a staple cartridge with a surgical instrument
US11376098B2 (en) 2019-06-28 2022-07-05 Cilag Gmbh International Surgical instrument system comprising an RFID system
US11464601B2 (en) 2019-06-28 2022-10-11 Cilag Gmbh International Surgical instrument comprising an RFID system for tracking a movable component
US11771419B2 (en) 2019-06-28 2023-10-03 Cilag Gmbh International Packaging for a replaceable component of a surgical stapling system
US11638587B2 (en) 2019-06-28 2023-05-02 Cilag Gmbh International RFID identification systems for surgical instruments
US11350938B2 (en) 2019-06-28 2022-06-07 Cilag Gmbh International Surgical instrument comprising an aligned rfid sensor
US11478241B2 (en) 2019-06-28 2022-10-25 Cilag Gmbh International Staple cartridge including projections
US11298127B2 (en) 2019-06-28 2022-04-12 Cilag GmbH Interational Surgical stapling system having a lockout mechanism for an incompatible cartridge
US11497492B2 (en) 2019-06-28 2022-11-15 Cilag Gmbh International Surgical instrument including an articulation lock
US11684434B2 (en) 2019-06-28 2023-06-27 Cilag Gmbh International Surgical RFID assemblies for instrument operational setting control
US11298132B2 (en) 2019-06-28 2022-04-12 Cilag GmbH Inlernational Staple cartridge including a honeycomb extension
US11426167B2 (en) 2019-06-28 2022-08-30 Cilag Gmbh International Mechanisms for proper anvil attachment surgical stapling head assembly
US11291451B2 (en) 2019-06-28 2022-04-05 Cilag Gmbh International Surgical instrument with battery compatibility verification functionality
US11684369B2 (en) 2019-06-28 2023-06-27 Cilag Gmbh International Method of using multiple RFID chips with a surgical assembly
US11523822B2 (en) 2019-06-28 2022-12-13 Cilag Gmbh International Battery pack including a circuit interrupter
US11399837B2 (en) 2019-06-28 2022-08-02 Cilag Gmbh International Mechanisms for motor control adjustments of a motorized surgical instrument
US11744593B2 (en) 2019-06-28 2023-09-05 Cilag Gmbh International Method for authenticating the compatibility of a staple cartridge with a surgical instrument
US11259803B2 (en) 2019-06-28 2022-03-01 Cilag Gmbh International Surgical stapling system having an information encryption protocol
US11660163B2 (en) 2019-06-28 2023-05-30 Cilag Gmbh International Surgical system with RFID tags for updating motor assembly parameters
US11553971B2 (en) 2019-06-28 2023-01-17 Cilag Gmbh International Surgical RFID assemblies for display and communication
US11627959B2 (en) 2019-06-28 2023-04-18 Cilag Gmbh International Surgical instruments including manual and powered system lockouts
US11241235B2 (en) 2019-06-28 2022-02-08 Cilag Gmbh International Method of using multiple RFID chips with a surgical assembly
US11219455B2 (en) 2019-06-28 2022-01-11 Cilag Gmbh International Surgical instrument including a lockout key
US11553919B2 (en) 2019-06-28 2023-01-17 Cilag Gmbh International Method for authenticating the compatibility of a staple cartridge with a surgical instrument
US11051807B2 (en) 2019-06-28 2021-07-06 Cilag Gmbh International Packaging assembly including a particulate trap
US11224497B2 (en) 2019-06-28 2022-01-18 Cilag Gmbh International Surgical systems with multiple RFID tags
US11504122B2 (en) 2019-12-19 2022-11-22 Cilag Gmbh International Surgical instrument comprising a nested firing member
US11911032B2 (en) 2019-12-19 2024-02-27 Cilag Gmbh International Staple cartridge comprising a seating cam
US11559304B2 (en) 2019-12-19 2023-01-24 Cilag Gmbh International Surgical instrument comprising a rapid closure mechanism
US11931033B2 (en) 2019-12-19 2024-03-19 Cilag Gmbh International Staple cartridge comprising a latch lockout
US11464512B2 (en) 2019-12-19 2022-10-11 Cilag Gmbh International Staple cartridge comprising a curved deck surface
US11529137B2 (en) 2019-12-19 2022-12-20 Cilag Gmbh International Staple cartridge comprising driver retention members
US11529139B2 (en) 2019-12-19 2022-12-20 Cilag Gmbh International Motor driven surgical instrument
US11844520B2 (en) 2019-12-19 2023-12-19 Cilag Gmbh International Staple cartridge comprising driver retention members
US11576672B2 (en) 2019-12-19 2023-02-14 Cilag Gmbh International Surgical instrument comprising a closure system including a closure member and an opening member driven by a drive screw
US11607219B2 (en) 2019-12-19 2023-03-21 Cilag Gmbh International Staple cartridge comprising a detachable tissue cutting knife
US11446029B2 (en) 2019-12-19 2022-09-20 Cilag Gmbh International Staple cartridge comprising projections extending from a curved deck surface
US11234698B2 (en) 2019-12-19 2022-02-01 Cilag Gmbh International Stapling system comprising a clamp lockout and a firing lockout
US11291447B2 (en) 2019-12-19 2022-04-05 Cilag Gmbh International Stapling instrument comprising independent jaw closing and staple firing systems
US11304696B2 (en) 2019-12-19 2022-04-19 Cilag Gmbh International Surgical instrument comprising a powered articulation system
US11701111B2 (en) 2019-12-19 2023-07-18 Cilag Gmbh International Method for operating a surgical stapling instrument
USD967421S1 (en) 2020-06-02 2022-10-18 Cilag Gmbh International Staple cartridge
USD976401S1 (en) 2020-06-02 2023-01-24 Cilag Gmbh International Staple cartridge
USD975851S1 (en) 2020-06-02 2023-01-17 Cilag Gmbh International Staple cartridge
USD974560S1 (en) 2020-06-02 2023-01-03 Cilag Gmbh International Staple cartridge
USD966512S1 (en) 2020-06-02 2022-10-11 Cilag Gmbh International Staple cartridge
USD975850S1 (en) 2020-06-02 2023-01-17 Cilag Gmbh International Staple cartridge
USD975278S1 (en) 2020-06-02 2023-01-10 Cilag Gmbh International Staple cartridge
US11857182B2 (en) 2020-07-28 2024-01-02 Cilag Gmbh International Surgical instruments with combination function articulation joint arrangements
US11660090B2 (en) 2020-07-28 2023-05-30 Cllag GmbH International Surgical instruments with segmented flexible drive arrangements
US11826013B2 (en) 2020-07-28 2023-11-28 Cilag Gmbh International Surgical instruments with firing member closure features
US11883024B2 (en) 2020-07-28 2024-01-30 Cilag Gmbh International Method of operating a surgical instrument
US11871925B2 (en) 2020-07-28 2024-01-16 Cilag Gmbh International Surgical instruments with dual spherical articulation joint arrangements
US11737748B2 (en) 2020-07-28 2023-08-29 Cilag Gmbh International Surgical instruments with double spherical articulation joints with pivotable links
US11638582B2 (en) 2020-07-28 2023-05-02 Cilag Gmbh International Surgical instruments with torsion spine drive arrangements
US11864756B2 (en) 2020-07-28 2024-01-09 Cilag Gmbh International Surgical instruments with flexible ball chain drive arrangements
US11534259B2 (en) 2020-10-29 2022-12-27 Cilag Gmbh International Surgical instrument comprising an articulation indicator
US11779330B2 (en) 2020-10-29 2023-10-10 Cilag Gmbh International Surgical instrument comprising a jaw alignment system
US11844518B2 (en) 2020-10-29 2023-12-19 Cilag Gmbh International Method for operating a surgical instrument
USD980425S1 (en) 2020-10-29 2023-03-07 Cilag Gmbh International Surgical instrument assembly
US11931025B2 (en) 2020-10-29 2024-03-19 Cilag Gmbh International Surgical instrument comprising a releasable closure drive lock
USD1013170S1 (en) 2020-10-29 2024-01-30 Cilag Gmbh International Surgical instrument assembly
US11452526B2 (en) 2020-10-29 2022-09-27 Cilag Gmbh International Surgical instrument comprising a staged voltage regulation start-up system
US11517390B2 (en) 2020-10-29 2022-12-06 Cilag Gmbh International Surgical instrument comprising a limited travel switch
US11717289B2 (en) 2020-10-29 2023-08-08 Cilag Gmbh International Surgical instrument comprising an indicator which indicates that an articulation drive is actuatable
US11617577B2 (en) 2020-10-29 2023-04-04 Cilag Gmbh International Surgical instrument comprising a sensor configured to sense whether an articulation drive of the surgical instrument is actuatable
US11896217B2 (en) 2020-10-29 2024-02-13 Cilag Gmbh International Surgical instrument comprising an articulation lock
USD1018577S1 (en) 2020-11-11 2024-03-19 Cilag Gmbh International Display screen or portion thereof with a graphical user interface for a surgical instrument
US11890010B2 (en) 2020-12-02 2024-02-06 Cllag GmbH International Dual-sided reinforced reload for surgical instruments
US11653915B2 (en) 2020-12-02 2023-05-23 Cilag Gmbh International Surgical instruments with sled location detection and adjustment features
US11737751B2 (en) 2020-12-02 2023-08-29 Cilag Gmbh International Devices and methods of managing energy dissipated within sterile barriers of surgical instrument housings
US11744581B2 (en) 2020-12-02 2023-09-05 Cilag Gmbh International Powered surgical instruments with multi-phase tissue treatment
US11653920B2 (en) 2020-12-02 2023-05-23 Cilag Gmbh International Powered surgical instruments with communication interfaces through sterile barrier
US11627960B2 (en) 2020-12-02 2023-04-18 Cilag Gmbh International Powered surgical instruments with smart reload with separately attachable exteriorly mounted wiring connections
US11849943B2 (en) 2020-12-02 2023-12-26 Cilag Gmbh International Surgical instrument with cartridge release mechanisms
US11678882B2 (en) 2020-12-02 2023-06-20 Cilag Gmbh International Surgical instruments with interactive features to remedy incidental sled movements
US11931034B2 (en) 2021-01-12 2024-03-19 Cilag Gmbh International Surgical stapling instruments with smart staple cartridges
US11723657B2 (en) 2021-02-26 2023-08-15 Cilag Gmbh International Adjustable communication based on available bandwidth and power capacity
US11751869B2 (en) 2021-02-26 2023-09-12 Cilag Gmbh International Monitoring of multiple sensors over time to detect moving characteristics of tissue
US11925349B2 (en) 2021-02-26 2024-03-12 Cilag Gmbh International Adjustment to transfer parameters to improve available power
US11749877B2 (en) 2021-02-26 2023-09-05 Cilag Gmbh International Stapling instrument comprising a signal antenna
US11701113B2 (en) 2021-02-26 2023-07-18 Cilag Gmbh International Stapling instrument comprising a separate power antenna and a data transfer antenna
US11812964B2 (en) 2021-02-26 2023-11-14 Cilag Gmbh International Staple cartridge comprising a power management circuit
US11696757B2 (en) 2021-02-26 2023-07-11 Cilag Gmbh International Monitoring of internal systems to detect and track cartridge motion status
US11744583B2 (en) 2021-02-26 2023-09-05 Cilag Gmbh International Distal communication array to tune frequency of RF systems
US11793514B2 (en) 2021-02-26 2023-10-24 Cilag Gmbh International Staple cartridge comprising sensor array which may be embedded in cartridge body
US11730473B2 (en) 2021-02-26 2023-08-22 Cilag Gmbh International Monitoring of manufacturing life-cycle
US11737749B2 (en) 2021-03-22 2023-08-29 Cilag Gmbh International Surgical stapling instrument comprising a retraction system
US11826042B2 (en) 2021-03-22 2023-11-28 Cilag Gmbh International Surgical instrument comprising a firing drive including a selectable leverage mechanism
US11806011B2 (en) 2021-03-22 2023-11-07 Cilag Gmbh International Stapling instrument comprising tissue compression systems
US11759202B2 (en) 2021-03-22 2023-09-19 Cilag Gmbh International Staple cartridge comprising an implantable layer
US11723658B2 (en) 2021-03-22 2023-08-15 Cilag Gmbh International Staple cartridge comprising a firing lockout
US11717291B2 (en) 2021-03-22 2023-08-08 Cilag Gmbh International Staple cartridge comprising staples configured to apply different tissue compression
US11826012B2 (en) 2021-03-22 2023-11-28 Cilag Gmbh International Stapling instrument comprising a pulsed motor-driven firing rack
US11786239B2 (en) 2021-03-24 2023-10-17 Cilag Gmbh International Surgical instrument articulation joint arrangements comprising multiple moving linkage features
US11793516B2 (en) 2021-03-24 2023-10-24 Cilag Gmbh International Surgical staple cartridge comprising longitudinal support beam
US11849944B2 (en) 2021-03-24 2023-12-26 Cilag Gmbh International Drivers for fastener cartridge assemblies having rotary drive screws
US11786243B2 (en) 2021-03-24 2023-10-17 Cilag Gmbh International Firing members having flexible portions for adapting to a load during a surgical firing stroke
US11744603B2 (en) 2021-03-24 2023-09-05 Cilag Gmbh International Multi-axis pivot joints for surgical instruments and methods for manufacturing same
US11896218B2 (en) 2021-03-24 2024-02-13 Cilag Gmbh International Method of using a powered stapling device
US11832816B2 (en) 2021-03-24 2023-12-05 Cilag Gmbh International Surgical stapling assembly comprising nonplanar staples and planar staples
US11896219B2 (en) 2021-03-24 2024-02-13 Cilag Gmbh International Mating features between drivers and underside of a cartridge deck
US11849945B2 (en) 2021-03-24 2023-12-26 Cilag Gmbh International Rotary-driven surgical stapling assembly comprising eccentrically driven firing member
US11857183B2 (en) 2021-03-24 2024-01-02 Cilag Gmbh International Stapling assembly components having metal substrates and plastic bodies
US11903582B2 (en) 2021-03-24 2024-02-20 Cilag Gmbh International Leveraging surfaces for cartridge installation
US11918217B2 (en) 2021-05-28 2024-03-05 Cilag Gmbh International Stapling instrument comprising a staple cartridge insertion stop
US11723662B2 (en) 2021-05-28 2023-08-15 Cilag Gmbh International Stapling instrument comprising an articulation control display
US11826047B2 (en) 2021-05-28 2023-11-28 Cilag Gmbh International Stapling instrument comprising jaw mounts
US11877745B2 (en) 2021-10-18 2024-01-23 Cilag Gmbh International Surgical stapling assembly having longitudinally-repeating staple leg clusters
US11931028B2 (en) 2022-02-03 2024-03-19 Cilag Gmbh International Surgical instrument with multiple program responses during a firing motion
US11931031B2 (en) 2022-05-27 2024-03-19 Cilag Gmbh International Staple cartridge comprising a deck including an upper surface and a lower surface
US11931038B2 (en) 2022-10-03 2024-03-19 Cilag Gmbh International Cartridge assemblies for surgical staplers

Also Published As

Publication number Publication date
US20030044444A1 (en) 2003-03-06

Similar Documents

Publication Publication Date Title
US8025896B2 (en) Porous extracellular matrix scaffold and method
US7201917B2 (en) Porous delivery scaffold and method
US20040166169A1 (en) Porous extracellular matrix scaffold and method
US7914808B2 (en) Hybrid biologic/synthetic porous extracellular matrix scaffolds
AU2002354915B8 (en) Porous extracellular matrix scaffold and method
US7163563B2 (en) Unitary surgical device and method
US7871440B2 (en) Unitary surgical device and method
AU2002313694B2 (en) Cartilage repair apparatus and method
AU2002316694A1 (en) Hybrid biologic/synthetic porous extracellular matrix scaffolds
AU2002354915A1 (en) Porous extracellular matrix scaffold and method
AU2002313694A1 (en) Cartilage repair apparatus and method
AU2002354913A1 (en) Unitary surgical device and method
JP2004522555A (en) Hybrid biosynthetic bioabsorbable scaffolds
JP2004522555A5 (en)
EP1416876B1 (en) Porous delivery scaffold and method
AU2002354912B2 (en) Porous delivery scaffold and method
AU2002354912A1 (en) Porous delivery scaffold and method
AU2005201981A1 (en) Hybrid biologic-synthetic bioabsorbable scaffolds

Legal Events

Date Code Title Description
AS Assignment

Owner name: DEPUY PRODUCTS, INC., INDIANA

Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNORS:MALAVIYA, PRASANNA;SCHWARTZ, HERBERT E.;PLOUHAR, PAMELA L.;AND OTHERS;REEL/FRAME:013577/0567;SIGNING DATES FROM 20021030 TO 20021113

Owner name: DEPUY PRODUCTS, INC., INDIANA

Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNORS:MALAVIYA, PRASANNA;SCHWARTZ, HERBERT E.;PLOUHAR, PAMELA L.;AND OTHERS;SIGNING DATES FROM 20021030 TO 20021113;REEL/FRAME:013577/0567

STCF Information on status: patent grant

Free format text: PATENTED CASE

AS Assignment

Owner name: DEPUY SYNTHES PRODUCTS, LLC, MASSACHUSETTS

Free format text: CHANGE OF NAME;ASSIGNOR:HAND INNOVATIONS LLC;REEL/FRAME:032998/0644

Effective date: 20121231

Owner name: DEPUY SPINE, LLC, MASSACHUSETTS

Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNOR:DEPUY PRODUCTS, INC.;REEL/FRAME:032949/0620

Effective date: 20121230

Owner name: HAND INNOVATIONS LLC, FLORIDA

Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNOR:DEPUY SPINE, LLC;REEL/FRAME:032949/0887

Effective date: 20121230

FPAY Fee payment

Year of fee payment: 4

MAFP Maintenance fee payment

Free format text: PAYMENT OF MAINTENANCE FEE, 8TH YEAR, LARGE ENTITY (ORIGINAL EVENT CODE: M1552); ENTITY STATUS OF PATENT OWNER: LARGE ENTITY

Year of fee payment: 8

MAFP Maintenance fee payment

Free format text: PAYMENT OF MAINTENANCE FEE, 12TH YEAR, LARGE ENTITY (ORIGINAL EVENT CODE: M1553); ENTITY STATUS OF PATENT OWNER: LARGE ENTITY

Year of fee payment: 12