US7850638B2 - Ocular pressure regulation - Google Patents

Ocular pressure regulation Download PDF

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US7850638B2
US7850638B2 US11/615,615 US61561506A US7850638B2 US 7850638 B2 US7850638 B2 US 7850638B2 US 61561506 A US61561506 A US 61561506A US 7850638 B2 US7850638 B2 US 7850638B2
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drainage tube
fluid drainage
eye
sclera
anterior chamber
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US20070106235A1 (en
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Minas Theodore Coroneo
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Alcon Inc
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Transcend Medical Inc
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F9/00Methods or devices for treatment of the eyes; Devices for putting-in contact lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
    • A61F9/007Methods or devices for eye surgery
    • A61F9/00781Apparatus for modifying intraocular pressure, e.g. for glaucoma treatment
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02Prostheses implantable into the body
    • A61F2/14Eye parts, e.g. lenses, corneal implants; Implanting instruments specially adapted therefor; Artificial eyes
    • A61F2/148Implantation instruments specially adapted therefor

Definitions

  • This invention is directed to therapeutic methods and devices for the treatment of glaucoma.
  • this invention is concerned with the use of a shunt or drain for the treatment of glaucoma.
  • this invention is concerned with ocular pressure spike shunts and use of the same in ocular surgery.
  • the glaucomas are a common group of blinding conditions usually associated with elevated intraocular pressure.
  • This elevated pressure in the eye may be regarded as a disorder of the drainage system of the eye which gives rise to the glaucomas.
  • Aqueous humor of the eye (“aqueous”) is a flowing liquid fluid (composed of sodium, chloride, bicarb, amino acids, glucose, ascorbic acid, and water) that is actively secreted by the ciliary body and flows out past the iris into the anterior chamber (are between the lens/iris and the cornea).
  • the aqueous drains out through angle formed by the iris and the sclera into a meshwork call the trabeculum, and from there into the canal of Schlemm and then into the episcleral veins. Uveosclera drainage also occurs.
  • Normal intraocular pressure (IOP) of aqueous in anterior chamber is between 10 and 20 mm Hg. Prolonged IOPs of greater than 21 mm Hg are associated with damage to optic nerve fibers.
  • angle glaucoma In some cases of glaucoma the cause can be found: the trabecular meshwork becomes blocked by pigment or membrane. In other cases, blockage is due to a closure of the angle between the iris and the cornea. This angle type of glaucoma is referred to as “angle-closure glaucoma”. In the majority of glaucoma cases, however, called “open angle glaucoma”, the cause is unknown.
  • Elevated intraocular pressure results in the death of retinal ganglion cells (which convey retinal information to the brain) resulting in a characteristic pattern of loss of the field of vision, progressing to tunnel vision and blindness if left untreated.
  • Treatment of glaucoma consists predominantly of methods to lower the intraocular pressure (pharmacological, trabecular meshwork laser and surgery to drain fluid from the eye). More recently protection of the retinal ganglion cells by neuroprotective agents has been attempted.
  • Surgery for glaucoma treatment is usually a trabeculectomy in which a fistula is created to drain fluid from the anterior chamber to the subconjunctival space near the limbus, creating a bulge in the conjunctiva known as a bleb. Frequently scarring occurs and attempts to counter this with antimetabolites such as Mitomycin C have met with some success.
  • glaucoma implants, drainage, shunt or valve devices have been developed e.g. Molteno (U.S. Pat. No. 4,457,757), Krupin (U.S. Pat. No. 5,454,746) and Baerveldt (U.S. Pat. No. 5,178,604).
  • Uveoscleral flow where aqueous humor flows through the interstitium of the ciliary muscle into the suprachoroidal space (a potential space between the choroids and sclera) and out through the sclera into the connective tissue of the orbit may account for 54% of outflow young healthy humans (Toris C B, Yablonski M E, Wang Y L, Camras C B “Aqueous humor dynamics in the aging human eye” Am J Ophthalmol, 1999; 127:407-12).
  • Cyclodialysis the separation of the ciliary body from the scleral spur and underlying sclera, creates free communication between the anterior chamber and the suprachoroidal space and enhances uveoscleral flow. It has long been known that cyclodialysis can cause a profound reduction of intraocular pressure—initially (Fuchs E. “Detachment of the choroid inadvertently during cataract surgery” [German] von Graefes Arch Ophthalmol, 1900; 51:199-224) cyclodialysis was recognized as a complication of cataract surgery. Deliberate creation of a cyclodialysis cleft for treating elevated intraocular pressure in uncontrolled glaucoma was first described as a surgical procedure in 1905 (Heine I.
  • the device and method of a first aspect of this invention takes advantage of the methods used in cataract surgery to develop a minimally invasive glaucoma procedure—thus small, self sealing incisions and materials that are biocompatible and foldable so that they fit through small openings will reduce surgical trauma and time.
  • the controlled draining of aqueous into the suprachoroidal space according to this invention provides some predictability of outcome and overcomes scarring problems that have plagued glaucoma implants in the past.
  • the increase may be marked and typically peaks at 5 to 7 hours before returning to near normal levels in 1 to 3 days (Hildebrand G D, Wickremasinghe S S, Tranos P G, Harris M L, Little B C. “Efficacy of anterior chamber decompression in controlling early intraocular pressure spikes after uneventful phacoemulsification” J Cataract Refract Surg., 2003; 29:1087-92).
  • Such pressure spikes can cause pain and may increase the risk of sight-threatening complications such as retinal vascular occlusion, increases loss of visual field in advanced glaucoma and ischemic optic neuropathy—effects in otherwise healthy eyes are unknown (Hildebrand G D et al, ibid).
  • prophylactic treatments include intracameral carbachol or acetylcholine, topical timolol, dorzolamide, aproclonidine, latanoprost and systemic acetazolamide (see Hildebrand G D et al, ibid).
  • This also exposes the patient to the risk of drug side effects, increased cost and it has been postulated that reducing the flow of aqueous humor post surgery prolongs the residence time of bacteria that frequently (46.3% of cases) contaminate the anterior chamber during surgery (Srinivasan R, Tiroumal S, Kanungo R, Natarajan M K.
  • a flexible ocular device for implantation into the eye formed of a biocompatible elastomeric material, foldable to a diameter of 1.5 mm or less, comprising a fluid drainage tube having at one end a foldable plate adapted to locate the device on the inner surface of the sclera in a suprachoroidal space formed by cyclodialysis, said drainage tube opening onto the disc at one end and opening to the anterior chamber when implanted into the eye at its other end, so as to provide aqueous pressure regulation.
  • the fluid drainage tube has a diameter selected to provide predetermined resistance to aqueous humor flow, for example a pressure of 10 mm Hg or less.
  • said tube contains a valve so as to regulate pressure of the aqueous chamber at a predetermined level, for example, at no less than 10 mm Hg.
  • a flexible ocular device formed of a biocompatible elastomeric material foldable to a diameter of 1.5 mm or less, comprising a fluid drainage tube having at one end a foldable plate adapted to locate the device on the inner surface of the sclera and at its other end being open so as to allow fluid communication through said tube;
  • an ocular pressure spike shunt for insertion into an ocular paracentesis incision port following ocular surgery, comprising a flexible fluid transfer tube formed of biocompatible material, preferably biocompatible elastomeric material, so as to allow paracentesis incision closure around said tube, having an inner end and an outer end, a tubular lumen disposed between said inner end and said outer end to allow fluid communication through said tube, said lumen containing a valve for controlling pressure in the eye following ocular surgery, which valve opens permitting fluid flow through said tube when a predetermined pressure is exceeded, said shunt being configured such that on insertion into a paracentesis port said outer end is substantially flush with the surface of the cornea, and said inner end opens into the anterior chamber of the eye.
  • a method for preventing ocular pressure spikes following ocular surgery wherein a paracentesis incision port is formed in the eye during said surgery, comprising introducing an ocular pressure spike shunt into said paracentesis port at the conclusion of ocular surgery, said shunt comprising a flexible fluid transfer tube formed of biocompatible material, preferably biocompatible elastomeric material, so as to allow paracentesis incision closure around said tube, having an inner end and an outer end, a tubular lumen disposed between said inner end and said outer end to allow fluid communication through said tube, said lumen containing a valve for controlling pressure in the eye following ocular surgery, which valve opens permitting fluid flow through said tube when a predetermined pressure is exceeded, said shunt being configured such that on insertion into a paracentesis port said outer end is substantially flush with the surface of the cornea, and said inner end protrudes into the anterior chamber of the eye.
  • FIG. 1 shows a diagrammatic representation of a side sectional view of suprachoroidal shunt insertion using an injector.
  • FIG. 2 shows a diagrammatic representation of a side sectional view of an eye showing the unfolded plate portion of the device and a cannula introducing said device across the anterior chamber at 180° to the site of insertion.
  • FIG. 3 shows a diagrammatic representation of an eye containing a pressure spike shunt inserted into a paracentesis port.
  • the ocular device according to the present invention is implanted in a patient's eye using minimally invasive surgery techniques, adopted from modern cataract surgery.
  • the ocular device is formed from a biocompatible elastomeric material.
  • the device is made of soft surgical grade polymeric material, such as silicon or acrylic material such that the device is foldable and may be rolled up for insertion via a cannula.
  • FIG. 1 shows a proximal end of a cannula forming a cyclodialysis. The folded device may be introduced via such a cannula
  • the elastomeric material is selected to be sufficiently soft that it does not erode delicate underlying choroid material when inserted into the eye. Such material and ocular lenses formed therefrom are well known and used in cataract surgery.
  • the foldable plate is adapted to locate the device on the inner surface of the sclera in a suprachoroidal space formed by cyclodialysis ( FIG. 2 ).
  • the plate is of a disc-like shape which matches the curvature of the eye once unfolded.
  • FIG. 2 depicts an unfolded disc (connected tube not shown) after cannula introduction across the anterior chamber (transcameral).
  • any plate-like configuration which locates the device on the inner surface of the sclera in the suprachoroidal space may be used, such as for example a rectangular foldable plate.
  • the plate diameter is from 0.05 to 6 mm, and preferably the place thickness is from 12.5 ⁇ m to 250 ⁇ m.
  • the fluid drainage tube of the ocular device is preferably integral with the plate, and is attached at one end to the plate, preferably at the periphery of the plate. Alternatively, the tube may be microwelded or otherwise fixed to the plate. Fabrication techniques well known in production of intraocular foldable lenses are preferably used in this invention.
  • the tube has a hollow lumen, and is preferably of a length from about 1 mm to 4 mm. Preferred diameters of the tubing comprise an outer diameter of 400-1000 ⁇ m, and preferably the inner diameter is from 50 to 500 ⁇ m.
  • the diameter of the tube may be selected so as to provide a resistance to aqueous humor flow of predetermined pressure, preferably being a pressure less than 10 mm Hg. This enables the pressure of the aqueous to be regulated in a controlled manner, providing relief from excess ocular pressure associated with glaucoma, with avoidance of hypotony (uncontrolled low pressure).
  • the tube may contain a valve, for example disposed at the end of the tube opening onto the disc so as to regulate ocular pressure at a predetermined level.
  • the valve prevents aqueous flow through the tube at a pressure of less than 10 mm Hg. Examples of valves which may be used include a slit valve. The drainage stops altogether if the pressure drops to a predetermined threshold level controlled by the valve.
  • the flexible foldable nature of the device according to the present invention enables well established techniques used in cataract surgery to be employed in the treatment of glaucoma.
  • the device according to the present invention may be folded into a cannula and introduced for location into the eye.
  • Intraocular surgery techniques allow a paracentesis (opening onto the anterior chamber from without at the juncture of the cornea and sclera—the limbus) to be performed and the anterior chamber filled with viscoelastic substance.
  • a cyclodialysis instrument is introduced via the paracentesis, with the paracentesis preferably being carried out 180° from the insertion site.
  • a cyclodialysis is carried out, for example by advancing an instrument tip into the angle between the ciliary body and sclera so as to create a cyclodialysis. This is preferably carried out with direct visualisation via gonioscopy lens viewed through an operating microscope.
  • a surgical gonioscopy lens is preferably placed on the cornea while the cyclodialysis is carried out.
  • the rolled up ocular device is introduced through a cannula, for example using an introducer such as used in cataract surgery or other ocular surgery, from which the device can be detached by pressing a plunger into the introducer when the device has been inserted into the suprachoroidal space created by the cyclodialysis.
  • the tubing of the device is positioned into the interior chamber, and the plate unfolds in the suprachoroidal space to locate the device in the eye. Because of its size, the device cannot fall through the opening through which it was introduced into the suprachoroidal space by the cyclodialysis.
  • the plate therefore keeps the tube in the appropriate position in the anterior chamber allowing controlled aqueous drainage and providing an effective treatment for elevated ocular pressure.
  • the pressure spike shunt is designed to fit snugly in a paracentesis port that is routinely made during cataract or other ocular surgery.
  • the tubing will not distort the port and there will be no leakage around the port.
  • the outer end of the tube will sit flush on the surface of the cornea—the inner aspect of the tube will preferably just protrude into the anterior chamber—tube length will generally be 1-2 mm and tube diameter is preferably from 0.4-1.2 mm.
  • the tube will contain the same valvular device as contained in the ocular device described above and will open when the intraocular pressure exceeds a predetermined level, preferably 10 mm Hg. At normal ocular pressure the valve will be closed, closing said tube to any fluid communication.
  • FIG. 3 shows a shunt located in a paracentesis port. In most cases the shunt will be removed and discarded at the first post-operative dressing.
  • the shunt may be inserted into a paracentesis port, or one or more ports, using, for example, a punctum plug inserting instrument such as described in U.S. Pat. No. 5,741,292.
  • Fresh whole porcine eyes were taken and mounted in a temperature controlled (37°) perfusion chamber.
  • the eyes were perfused with Balanced Salt Solution via a 30 gauge needle inserted via a paracentesis into the anterior chamber.
  • a peristaltic pump was used at a flow rate of 2 ⁇ l/min.
  • Intraocular pressure was continuously monitored via a second paracentesis.
  • Adequate anesthesia is provided to the eye of a glaucoma patient prepared for intraocular surgery.
  • a paracentesis (opening into anterior chamber from without at the junction of the cornea and sclera—the limbus) is performed and the anterior chamber is filled with a viscoelastic substance.
  • a surgical gonioscopy lens is placed on the cornea (or anterior segment endoscope is used) and a cyclodialysis instrument is introduced via the paracentesis—the paracentesis is carried out 180° away from the planned implant insertion site.
  • the cyclodialysis instrument tip is advanced into the angle and pushed into the space between the ciliary body and sclera creating a cyclodialysis—this is carried out with direct visualization via the gonioscopy lens viewed through an operating microscope.
  • the area in the angle can be lasered either preoperatively or at the time of surgery to ablate surface blood vessels).
  • viscoelastic is inserted to further create a space in the suprachoroidal space.
  • the implant is then introduced—the device is rolled up in the same manner as an ultrathin intraocular lens.
  • the ocular device is attached to an introducer from which it is detached by pushing a plunger in the introducer when the implant is inserted into the suprachoroidal space created by the cyclodialysis instrument and viscoelastic.
  • the tubing is then positioned into the anterior chamber and may be cut to size.
  • the plate unfolds in the suprachoroidal space and because of its size cannot fall through the opening through which it was introduced into the suprachoroidal space. The plate therefore keeps the tube in an appropriate position.
  • the valve is then flushed (with a cannula inserted via the paracentesis) via the tube opening in the anterior chamber. Viscoelastic is then removed from the anterior chamber and antibiotics, steroids and a dressing applied to the eye.
  • Fresh whole porcine eyes were taken and mounted in a temperature-controlled (37°) perfusion chamber as in Example 1.
  • the eyes were perfused with Balanced Salt Solution via a 30 gauge needle inserted via a paracentesis into the anterior chamber.
  • a peristaltic pump was used at a flow rate of 2 ⁇ l/min.
  • Intraocular pressure was continuously monitored via a second paracentesis.
  • Intraocular pressures typically stabilized at 10-15 mm Hg and fell with time (the “washout effect, as glycoaminoglycans are washed out of the trabecular meshwork with time).
  • Silicone tubing (length 3 mm, external diameter 1 mm) was introduced into one paracentesis port. One end of the port (outer end) was flush with the cornea and the inner end of the port extended slightly into the anterior chamber. Intraocular pressure did not exceed 10 mm Hg.

Abstract

This invention comprises a flexible ocular device for implantation into the eye formed of a biocompatible elastomeric material, foldable to a diameter of 1.5 mm or less, comprising a fluid drainage tube having at one end a foldable plate adapted to locate the device on the inner surface of the sclera in a suprachoroidal space formed by cyclodialysis, said drainage tube opening onto the disc at one end and opening to the anterior chamber when implanted into the eye at its other end, so as to provide aqueous pressure regulation. Also provided are methods for the treatment of glaucoma utilizing the flexible ocular device, and an ocular pressure spike shunt.

Description

RELATED APPLICATIONS
This application is a continuation of U.S. application Ser. No. 10/712,277, filed Nov. 14, 2003, now U.S. Pat. No. 7,291,125 entitled “OCULAR PRESSURE REGULATION” by Minas Coroneo.
This application also is related to U.S. application Ser. No. 10/579,330, filed Nov. 12, 2004, entitled “OCULAR PRESSURE REGULATION” by Minas Coroneo; and to U.S. application Ser. No. 11/615,642, filed the same day herewith.
Where permitted, the subject matter of each of the above noted applications is incorporated by reference in its entirety by reference thereto.
FIELD OF THE INVENTION
This invention is directed to therapeutic methods and devices for the treatment of glaucoma. In particular, this invention is concerned with the use of a shunt or drain for the treatment of glaucoma. In another aspect this invention is concerned with ocular pressure spike shunts and use of the same in ocular surgery.
BACKGROUND OF THE INVENTION
The glaucomas are a common group of blinding conditions usually associated with elevated intraocular pressure. This elevated pressure in the eye may be regarded as a disorder of the drainage system of the eye which gives rise to the glaucomas.
Aqueous humor of the eye (“aqueous”) is a flowing liquid fluid (composed of sodium, chloride, bicarb, amino acids, glucose, ascorbic acid, and water) that is actively secreted by the ciliary body and flows out past the iris into the anterior chamber (are between the lens/iris and the cornea). The aqueous drains out through angle formed by the iris and the sclera into a meshwork call the trabeculum, and from there into the canal of Schlemm and then into the episcleral veins. Uveosclera drainage also occurs. Normal intraocular pressure (IOP) of aqueous in anterior chamber is between 10 and 20 mm Hg. Prolonged IOPs of greater than 21 mm Hg are associated with damage to optic nerve fibers.
In some cases of glaucoma the cause can be found: the trabecular meshwork becomes blocked by pigment or membrane. In other cases, blockage is due to a closure of the angle between the iris and the cornea. This angle type of glaucoma is referred to as “angle-closure glaucoma”. In the majority of glaucoma cases, however, called “open angle glaucoma”, the cause is unknown.
Elevated intraocular pressure results in the death of retinal ganglion cells (which convey retinal information to the brain) resulting in a characteristic pattern of loss of the field of vision, progressing to tunnel vision and blindness if left untreated.
Treatment of glaucoma consists predominantly of methods to lower the intraocular pressure (pharmacological, trabecular meshwork laser and surgery to drain fluid from the eye). More recently protection of the retinal ganglion cells by neuroprotective agents has been attempted.
Although pharmacological treatments of glaucoma have improved, they have important implications for the patient's quality of life, have compliance issues which are important in the elderly (in whom glaucoma is prevalent), expose the patient of glaucoma to side effects, and over a lifetime are costly.
Surgery for glaucoma treatment is usually a trabeculectomy in which a fistula is created to drain fluid from the anterior chamber to the subconjunctival space near the limbus, creating a bulge in the conjunctiva known as a bleb. Frequently scarring occurs and attempts to counter this with antimetabolites such as Mitomycin C have met with some success. In recalcitrant cases, glaucoma implants, drainage, shunt or valve devices have been developed e.g. Molteno (U.S. Pat. No. 4,457,757), Krupin (U.S. Pat. No. 5,454,746) and Baerveldt (U.S. Pat. No. 5,178,604). These suffer from similar problems of scarring (Classen L, Kivela T, Tarkkanen “A Histopathologic and immunohistochemical analysis of the filtration bleb after unsuccessful glaucoma seton implantation” Am J Ophthalmol, 1996; 122:205-12) around the external opening of the tube devices in the subconjunctival space—the development of a large number of these devices is testament to the fact that many fail in the longer term. In these devices a drainage tube is located in the anterior chamber and is in fluid communication with the sclera or a surgically created subconjunctival space.
Whereas cataract surgery has been revolutionized in the last two decades, improvements in glaucoma surgery have been slower. Antifibrotic agents have improved the success rate of conventional filtration surgery (trabeculectomy), but with increased bleb leaks, blebitis, endophthalmitis and hypotensive maculopathy. Glaucoma shunts have had limited success in eyes that have “failed” multiple standard procedures. However complications with malpositioned tubes, erosion and strabismus persist. A considerable issue is the lack of reproducibility and predictability in achieving the desired target intraocular pressure (IOP). Final IOP is largely determined by healing which can be unpredictable—in view of vast biological variations, it is impossible to predict which eyes will rapidly scar causing failure and which will fail to heal resulting in prolonged post-operative hypotony. Scarring remains a significant problem in all these external drainage proposals, where aqueous drains into the conjunctiva, or surgical chambers in the sclera.
The introduction of a new class of antiglaucoma drugs, the prostaglandin analogues, has resulted in acknowledgment of the importance of the uveoscleral pathway in drainage of fluid form the eye (Hylton C, Robin A L “Update on prostaglandin analogs” Curr Opin Ophthalmol, 2003; 14:65-9). Uveoscleral flow where aqueous humor flows through the interstitium of the ciliary muscle into the suprachoroidal space (a potential space between the choroids and sclera) and out through the sclera into the connective tissue of the orbit may account for 54% of outflow young healthy humans (Toris C B, Yablonski M E, Wang Y L, Camras C B “Aqueous humor dynamics in the aging human eye” Am J Ophthalmol, 1999; 127:407-12).
Cyclodialysis, the separation of the ciliary body from the scleral spur and underlying sclera, creates free communication between the anterior chamber and the suprachoroidal space and enhances uveoscleral flow. It has long been known that cyclodialysis can cause a profound reduction of intraocular pressure—initially (Fuchs E. “Detachment of the choroid inadvertently during cataract surgery” [German] von Graefes Arch Ophthalmol, 1900; 51:199-224) cyclodialysis was recognized as a complication of cataract surgery. Deliberate creation of a cyclodialysis cleft for treating elevated intraocular pressure in uncontrolled glaucoma was first described as a surgical procedure in 1905 (Heine I. “Cyclodialysis, a new glaucoma operation” [German]) Dtsch Med Wochenschr, 1905; 31:824-826). Since such clefts can heal and close spontaneously a number of devices have been used to keep them open, including platinum wire, horse hair, magnesium strips, tantalum foil, Supramid®, gelatin film, Teflon®, silicone and polymethylmethacrylate (Rosenberg L F, Krupin T. “Implants in glaucoma surgery” Chapter 88, The Glaucomas, Ritch R, Shields B M, Krupin T Eds. 2nd Edition Mosby St Louis 1986) and Hema (Mehta K R. “The suprachoroidal Hema wedge in glaucoma surgery” American Academy of Ophthalmology meeting 1977, pp 144). However the success rate of such approaches has been low (as low as 15%, Rosenburg & Krupin ibid and Gross R L, Feldman R M, Spaeth G L, et al “Surgical therapy of chronic glaucoma in aphakia and pseudophakia” Ophthalmology, 1988; 95:1195-201). Failure was due to uncontrolled low pressure (hypotony) with consequential macular edema, bleeding (hyphema) and inadequate pressure control.
The device and method of a first aspect of this invention takes advantage of the methods used in cataract surgery to develop a minimally invasive glaucoma procedure—thus small, self sealing incisions and materials that are biocompatible and foldable so that they fit through small openings will reduce surgical trauma and time. The controlled draining of aqueous into the suprachoroidal space according to this invention provides some predictability of outcome and overcomes scarring problems that have plagued glaucoma implants in the past.
The most frequent complication following modern cataract surgery with phacoemulsification, requiring specific treatment is elevated intraocular pressure (Cohen V M, Demetria H, Jordan K, Lamb R J, Vivian A J. :First day post-operative review following uncomplicated phacoemulsification” Eye, 1998; 12 (Pt 4):634-6, and Dinakaran S, Desai S P, Raj P S. “Is the first post-operative day review necessary following uncomplicated phacoemulsification surgery?” Eye, 2000 June; 14 (Pt 3A):364-6). The increase may be marked and typically peaks at 5 to 7 hours before returning to near normal levels in 1 to 3 days (Hildebrand G D, Wickremasinghe S S, Tranos P G, Harris M L, Little B C. “Efficacy of anterior chamber decompression in controlling early intraocular pressure spikes after uneventful phacoemulsification” J Cataract Refract Surg., 2003; 29:1087-92). Such pressure spikes can cause pain and may increase the risk of sight-threatening complications such as retinal vascular occlusion, increases loss of visual field in advanced glaucoma and ischemic optic neuropathy—effects in otherwise healthy eyes are unknown (Hildebrand G D et al, ibid).
A number of prophylactic treatments are used with limited success—these include intracameral carbachol or acetylcholine, topical timolol, dorzolamide, aproclonidine, latanoprost and systemic acetazolamide (see Hildebrand G D et al, ibid). This also exposes the patient to the risk of drug side effects, increased cost and it has been postulated that reducing the flow of aqueous humor post surgery prolongs the residence time of bacteria that frequently (46.3% of cases) contaminate the anterior chamber during surgery (Srinivasan R, Tiroumal S, Kanungo R, Natarajan M K. “Microbial contamination of the anterior chamber during phacoemulsification” J Cataract Refract Surg, 2002; 28:2173-6). This may increase the risk of endophthalmitis one of the most devastating sequelae of intraocular surgery, since the bacteria are not being “flushed out” of the eye by the normal production of aqueous humour, the secretion of which has been suppressed by the drugs. Another technique is to decompress the anterior chamber by applying pressure to the posterior lip of the paracentesis wound at the appropriate time. This requires surveillance and could increase the risk of infection. Another aspect of this invention hereinafter described overcomes these problems.
SUMMARY OF THE INVENTION
According to the present invention there is provided a flexible ocular device for implantation into the eye formed of a biocompatible elastomeric material, foldable to a diameter of 1.5 mm or less, comprising a fluid drainage tube having at one end a foldable plate adapted to locate the device on the inner surface of the sclera in a suprachoroidal space formed by cyclodialysis, said drainage tube opening onto the disc at one end and opening to the anterior chamber when implanted into the eye at its other end, so as to provide aqueous pressure regulation.
Preferably the fluid drainage tube has a diameter selected to provide predetermined resistance to aqueous humor flow, for example a pressure of 10 mm Hg or less. Alternatively said tube contains a valve so as to regulate pressure of the aqueous chamber at a predetermined level, for example, at no less than 10 mm Hg.
In accordance with another embodiment of this invention there is provided a method for treating glaucoma which comprises:
providing a flexible ocular device formed of a biocompatible elastomeric material foldable to a diameter of 1.5 mm or less, comprising a fluid drainage tube having at one end a foldable plate adapted to locate the device on the inner surface of the sclera and at its other end being open so as to allow fluid communication through said tube;
forming a small self-sealing incision at the juncture of the cornea and sclera of the eye opening into the anterior chamber;
filling the anterior chamber with a viscoelastic substance;
introducing the foldable ocular device into a suprachoroidal space formed by cyclodialysis via a hollow cannula, wherein said plate locates the device on the inner surface of the sclera in the suprachoroidal space, and said drainage tube is located in the anterior chamber of the eye so as to provide aqueous humor pressure regulation; and
thereafter removing said cannula and viscoelastic material from the eye.
In another aspect there is provided an ocular pressure spike shunt for insertion into an ocular paracentesis incision port following ocular surgery, comprising a flexible fluid transfer tube formed of biocompatible material, preferably biocompatible elastomeric material, so as to allow paracentesis incision closure around said tube, having an inner end and an outer end, a tubular lumen disposed between said inner end and said outer end to allow fluid communication through said tube, said lumen containing a valve for controlling pressure in the eye following ocular surgery, which valve opens permitting fluid flow through said tube when a predetermined pressure is exceeded, said shunt being configured such that on insertion into a paracentesis port said outer end is substantially flush with the surface of the cornea, and said inner end opens into the anterior chamber of the eye.
In another aspect there is provided a method for preventing ocular pressure spikes following ocular surgery wherein a paracentesis incision port is formed in the eye during said surgery, comprising introducing an ocular pressure spike shunt into said paracentesis port at the conclusion of ocular surgery, said shunt comprising a flexible fluid transfer tube formed of biocompatible material, preferably biocompatible elastomeric material, so as to allow paracentesis incision closure around said tube, having an inner end and an outer end, a tubular lumen disposed between said inner end and said outer end to allow fluid communication through said tube, said lumen containing a valve for controlling pressure in the eye following ocular surgery, which valve opens permitting fluid flow through said tube when a predetermined pressure is exceeded, said shunt being configured such that on insertion into a paracentesis port said outer end is substantially flush with the surface of the cornea, and said inner end protrudes into the anterior chamber of the eye.
DESCRIPTION OF THE FIGURES
FIG. 1 shows a diagrammatic representation of a side sectional view of suprachoroidal shunt insertion using an injector.
FIG. 2 shows a diagrammatic representation of a side sectional view of an eye showing the unfolded plate portion of the device and a cannula introducing said device across the anterior chamber at 180° to the site of insertion.
FIG. 3 shows a diagrammatic representation of an eye containing a pressure spike shunt inserted into a paracentesis port.
DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS OF THE INVENTION
The ocular device according to the present invention is implanted in a patient's eye using minimally invasive surgery techniques, adopted from modern cataract surgery.
The ocular device is formed from a biocompatible elastomeric material. Preferably, the device is made of soft surgical grade polymeric material, such as silicon or acrylic material such that the device is foldable and may be rolled up for insertion via a cannula. FIG. 1 shows a proximal end of a cannula forming a cyclodialysis. The folded device may be introduced via such a cannula The elastomeric material is selected to be sufficiently soft that it does not erode delicate underlying choroid material when inserted into the eye. Such material and ocular lenses formed therefrom are well known and used in cataract surgery.
Sutures are not required to hold the device in place once surgically introduced into the eye, as the foldable plate is adapted to locate the device on the inner surface of the sclera in a suprachoroidal space formed by cyclodialysis (FIG. 2). Preferably, the plate is of a disc-like shape which matches the curvature of the eye once unfolded. FIG. 2 depicts an unfolded disc (connected tube not shown) after cannula introduction across the anterior chamber (transcameral). Alternatively, any plate-like configuration which locates the device on the inner surface of the sclera in the suprachoroidal space may be used, such as for example a rectangular foldable plate. Preferably the plate diameter is from 0.05 to 6 mm, and preferably the place thickness is from 12.5 μm to 250 μm. The fluid drainage tube of the ocular device is preferably integral with the plate, and is attached at one end to the plate, preferably at the periphery of the plate. Alternatively, the tube may be microwelded or otherwise fixed to the plate. Fabrication techniques well known in production of intraocular foldable lenses are preferably used in this invention. The tube has a hollow lumen, and is preferably of a length from about 1 mm to 4 mm. Preferred diameters of the tubing comprise an outer diameter of 400-1000 μm, and preferably the inner diameter is from 50 to 500 μm.
The diameter of the tube may be selected so as to provide a resistance to aqueous humor flow of predetermined pressure, preferably being a pressure less than 10 mm Hg. This enables the pressure of the aqueous to be regulated in a controlled manner, providing relief from excess ocular pressure associated with glaucoma, with avoidance of hypotony (uncontrolled low pressure). Alternatively, the tube may contain a valve, for example disposed at the end of the tube opening onto the disc so as to regulate ocular pressure at a predetermined level. Preferably, the valve prevents aqueous flow through the tube at a pressure of less than 10 mm Hg. Examples of valves which may be used include a slit valve. The drainage stops altogether if the pressure drops to a predetermined threshold level controlled by the valve.
The flexible foldable nature of the device according to the present invention enables well established techniques used in cataract surgery to be employed in the treatment of glaucoma. The device according to the present invention may be folded into a cannula and introduced for location into the eye.
Intraocular surgery techniques allow a paracentesis (opening onto the anterior chamber from without at the juncture of the cornea and sclera—the limbus) to be performed and the anterior chamber filled with viscoelastic substance. A cyclodialysis instrument is introduced via the paracentesis, with the paracentesis preferably being carried out 180° from the insertion site. A cyclodialysis is carried out, for example by advancing an instrument tip into the angle between the ciliary body and sclera so as to create a cyclodialysis. This is preferably carried out with direct visualisation via gonioscopy lens viewed through an operating microscope. A surgical gonioscopy lens is preferably placed on the cornea while the cyclodialysis is carried out.
The rolled up ocular device is introduced through a cannula, for example using an introducer such as used in cataract surgery or other ocular surgery, from which the device can be detached by pressing a plunger into the introducer when the device has been inserted into the suprachoroidal space created by the cyclodialysis. The tubing of the device is positioned into the interior chamber, and the plate unfolds in the suprachoroidal space to locate the device in the eye. Because of its size, the device cannot fall through the opening through which it was introduced into the suprachoroidal space by the cyclodialysis. The plate therefore keeps the tube in the appropriate position in the anterior chamber allowing controlled aqueous drainage and providing an effective treatment for elevated ocular pressure.
The pressure spike shunt is designed to fit snugly in a paracentesis port that is routinely made during cataract or other ocular surgery. The tubing will not distort the port and there will be no leakage around the port. The outer end of the tube will sit flush on the surface of the cornea—the inner aspect of the tube will preferably just protrude into the anterior chamber—tube length will generally be 1-2 mm and tube diameter is preferably from 0.4-1.2 mm. The tube will contain the same valvular device as contained in the ocular device described above and will open when the intraocular pressure exceeds a predetermined level, preferably 10 mm Hg. At normal ocular pressure the valve will be closed, closing said tube to any fluid communication. FIG. 3 shows a shunt located in a paracentesis port. In most cases the shunt will be removed and discarded at the first post-operative dressing.
The shunt may be inserted into a paracentesis port, or one or more ports, using, for example, a punctum plug inserting instrument such as described in U.S. Pat. No. 5,741,292.
This invention will now be described with reference to the following examples.
EXAMPLE 1
Fresh whole porcine eyes were taken and mounted in a temperature controlled (37°) perfusion chamber. The eyes were perfused with Balanced Salt Solution via a 30 gauge needle inserted via a paracentesis into the anterior chamber. A peristaltic pump was used at a flow rate of 2 μl/min. Intraocular pressure was continuously monitored via a second paracentesis.
Typically intraocular pressures stabilized at 10-15 mm Hg and fell with time (the “washout effect”, as glycosan aminoglycans are washed out of the trabecular meshwork with time). Creation of a cyclodialysis (initially with a small spatula, then viscoelastic injection to enlarge the area of detachment of the ciliary body from the sclera) with or without insertion of the device in the cyclodialysis cleft (silicone tubing, length 3 mm, external diameter—1 mm, plate diameter 3 mm) resulted in lower intraocular pressures (below 10 mm Hg) on reperfusion at the same perfusion rate as control eyes.
EXAMPLE 2
Adequate anesthesia is provided to the eye of a glaucoma patient prepared for intraocular surgery. A paracentesis (opening into anterior chamber from without at the junction of the cornea and sclera—the limbus) is performed and the anterior chamber is filled with a viscoelastic substance. A surgical gonioscopy lens is placed on the cornea (or anterior segment endoscope is used) and a cyclodialysis instrument is introduced via the paracentesis—the paracentesis is carried out 180° away from the planned implant insertion site. The cyclodialysis instrument tip is advanced into the angle and pushed into the space between the ciliary body and sclera creating a cyclodialysis—this is carried out with direct visualization via the gonioscopy lens viewed through an operating microscope. In order to minimize bleeding, the area in the angle (anterior ciliary body face and overlying trabecular meshwork) can be lasered either preoperatively or at the time of surgery to ablate surface blood vessels).
Through an opening at the tip of the cyclodialysis instrument viscoelastic is inserted to further create a space in the suprachoroidal space. The implant is then introduced—the device is rolled up in the same manner as an ultrathin intraocular lens. The ocular device is attached to an introducer from which it is detached by pushing a plunger in the introducer when the implant is inserted into the suprachoroidal space created by the cyclodialysis instrument and viscoelastic. The tubing is then positioned into the anterior chamber and may be cut to size. The plate unfolds in the suprachoroidal space and because of its size cannot fall through the opening through which it was introduced into the suprachoroidal space. The plate therefore keeps the tube in an appropriate position. The valve is then flushed (with a cannula inserted via the paracentesis) via the tube opening in the anterior chamber. Viscoelastic is then removed from the anterior chamber and antibiotics, steroids and a dressing applied to the eye.
EXAMPLE 3
Fresh whole porcine eyes were taken and mounted in a temperature-controlled (37°) perfusion chamber as in Example 1. The eyes were perfused with Balanced Salt Solution via a 30 gauge needle inserted via a paracentesis into the anterior chamber. A peristaltic pump was used at a flow rate of 2 μl/min. Intraocular pressure was continuously monitored via a second paracentesis.
Typically intraocular pressures stabilized at 10-15 mm Hg and fell with time (the “washout effect, as glycoaminoglycans are washed out of the trabecular meshwork with time). Silicone tubing (length 3 mm, external diameter 1 mm) was introduced into one paracentesis port. One end of the port (outer end) was flush with the cornea and the inner end of the port extended slightly into the anterior chamber. Intraocular pressure did not exceed 10 mm Hg.

Claims (46)

1. A method of placing an ocular device into the eye, comprising:
providing a fluid drainage tube having a longitudinal, internal lumen, a first end and a second end;
forming a self-sealing incision in the cornea into the anterior chamber of the eye;
introducing the first end and second end of the fluid drainage tube through the self-sealing incision and into the anterior chamber;
separating at least a portion of the ciliary body from at least a portion of the sclera from within the anterior chamber so as to place the fluid drainage tube such that when implanted into the eye the first end of the drainage tube communicates with the suprachoroidal space, the second end of the fluid drainage tube is in the anterior chamber, and the internal lumen provides a pathway for aqueous humor to flow through the fluid drainage tube from the anterior chamber to the suprachoroidal space, so as to provide aqueous pressure regulation.
2. The method of claim 1, wherein the aqueous pressure of the eye is maintained at a pressure of not less than 10 mmHg.
3. The method of claim 1, wherein the step of forming a self-sealing incision is performed under direct visualization utilizing a gonioscopy lens.
4. The method of claim 1, wherein the self-sealing incision is created in the cornea 180 degrees away from a planned insertion site of the fluid drainage tube in the eye.
5. The method of claim 1, further comprising injecting a viscoelastic substance into the anterior chamber of the eye prior to introducing the fluid drainage tube through the self-sealing incision.
6. The method of claim 1, further comprising injecting a viscoelastic substance into the eye such that the substance extends into the suprachoroidal space.
7. The method of claim 1, further comprising applying laser energy to the trabecular meshwork of the eye during the procedure method provided herein.
8. The method of claim 1, wherein separating at least a portion of the ciliary body from at least a portion of the sclera comprises performing a cyclodialysis.
9. The method of claim 8, wherein the cyclodialysis is performed using an ocular instrument separate from the fluid drainage tube.
10. The method of claim 1, wherein the fluid drainage tube is placed in the eye after separating at least a portion of the ciliary body from at least a portion of the sclera.
11. A method as in claim 1, further comprising filling the anterior chamber with a viscoelastic substance.
12. A method as in claim 1, further comprising using a viscoelastic substance to enlarge the suprachoroidal space.
13. A method as in claim 1, further comprising using a viscoelastic substance to enlarge an area of separation of the ciliary body from the sclera.
14. A method as in claim 1, further comprising injecting a viscoelastic substance through an attachment between the ciliary body and the sclera.
15. The method of claim 1, wherein the incision is formed in the limbus of the cornea.
16. The method of claim 1, wherein the fluid drainage tube includes an anchor, and further comprising placing the fluid drainage tube in the eye such that the anchor is at least partially located on an inner surface of the sclera.
17. The method of claim 1, wherein the fluid drainage tube includes an anchor, and further comprising placing the fluid drainage tube in the eye such that the anchor is at least partially located in the suprachoroidal space.
18. The method of claim 1, wherein the fluid drainage tube is attached to an introducer and the introducer is used to introduce the fluid drainage tube through the self-sealing incision and to place the fluid drainage tube.
19. The method of claim 18, further comprising detaching the fluid drainage tube from the introducer using a plunger.
20. The method of claim 1, wherein the tube is substantially circular in cross-section.
21. A method of treating an eye, comprising:
providing a fluid drainage tube having a longitudinal, internal lumen through which fluid can flow;
forming an opening in the cornea to provide access to the anterior chamber of the eye;
inserting the entire fluid drainage tube through the opening into the anterior chamber;
accessing the sclera and the ciliary body of the eye from within the anterior chamber; and
separating at least a portion of the sclera from at least a portion of the ciliary body and implanting the fluid drainage tube in the eye from within the anterior chamber such that the internal lumen provides a direct flow pathway from the anterior chamber to the suprachoroidal space of the eye.
22. A method as in claim 21, wherein implanting the fluid drainage tube comprises positioning the fluid drainage tube so that a first end of the fluid drainage tube is located in the anterior chamber and a second end of the fluid drainage tube is located adjacent an inner surface of the sclera in fluid communication with the suprachoroidal space.
23. A method as in claim 21, wherein the fluid drainage tube includes an anchor, and further comprising positioning the fluid drainage tube in the eye such that at least a portion of the anchor is on the inner surface of the sclera.
24. A method as in claim 21, wherein forming an opening in the cornea comprises forming a self-sealing incision in the cornea.
25. A method as in claim 21, wherein the opening is formed in the limbus.
26. A method as in claim 21, further comprising using an instrument to separate at least a portion of the sclera from at least a portion of the ciliary body.
27. A method as in claim 21, further comprising attaching the fluid drainage tube to an introducer and using the introducer to insert the fluid drainage tube through the opening and further using the introducer to implant the fluid drainage tube in the eye.
28. A method as in claim 27, further comprising detaching the fluid drainage tube from the introducer using a plunger.
29. A method as in claim 21, further comprising filling the anterior chamber with a viscoelastic substance.
30. A method as in claim 21, further comprising using a viscoelastic substance to enlarge the suprachoroidal space.
31. A method as in claim 21, further comprising using a viscoelastic substance to enlarge an area of detachment of the ciliary body from the sclera.
32. A method as in claim 21, further comprising injecting a viscoelastic substance through an attachment between the ciliary body and the sclera.
33. A method as in claim 21, wherein separating at least a portion of the sclera from at least a portion of the ciliary body comprises performing a cyclodialysis.
34. A method as in claim 1, wherein the fluid drainage tube is implanted in the eye such that the entire fluid drainage tube located posterior of the scleral spur is positioned adjacent the inner surface of the sclera and on a single side of the sclera.
35. A method as in claim 1, wherein the fluid drainage tube is implanted in the eye such that sutures are not required to hold the device in place.
36. A method as in claim 1, further comprising passing the first end and the second end of the fluid drainage tube across the anterior chamber as the device is being introduced.
37. A method as in claim 1, wherein when implanted into the eye the first end of the drainage tube is in the suprachoroidal space.
38. A method as in claim 1, wherein introducing the first end and the second end of the fluid drainage tube through the self-sealing incision comprises sequentially passing the first end and then the second end into the anterior chamber as the implant is being introduced.
39. A method as in claim 38, wherein the first end and the second end of the fluid drainage tube are sequentially passed such that the first end and second end are concurrently located within the anterior chamber.
40. The method of claim 1, wherein separating at least a portion of the ciliary body from at least a portion of the sclera comprises detaching the portion of the ciliary body from the portion of the sclera.
41. A method as in claim 21, wherein the fluid drainage tube is implanted in the eye such that an entire portion of the fluid drainage tube located posterior of the scleral spur is positioned adjacent the inner surface of the sclera and on a single side of the sclera.
42. A method as in claim 21, wherein the fluid drainage tube is implanted in the eye such that sutures are not required to hold the device in place.
43. A method as in claim 21, further comprising passing the entire fluid drainage tube across the anterior chamber as the device is being inserted.
44. A method as in claim 21, wherein inserting the entire fluid drainage tube through the opening into the anterior chamber comprises sequentially passing a distal end and then a proximal end of the fluid drainage tube into the anterior chamber as the fluid drainage tube is being inserted.
45. A method as in claim 44, wherein sequentially passing the distal end and the proximal end of the fluid draining tube into the anterior chamber comprises passing the distal and proximal end such that they are concurrently located within the anterior chamber.
46. A method as in claim 21, wherein separating at least a portion of the sclera from at least a portion of the ciliary body comprises detaching the portion of the ciliary body from the portion of the sclera.
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Cited By (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20080228127A1 (en) * 2006-11-10 2008-09-18 Glaukos Corporation Uveoscleral shunt and methods for implanting same
US20090143712A1 (en) * 2001-04-07 2009-06-04 Glaukos Corporation Self-trephining implant and methods thereof for treatment of ocular disorders
US8007459B2 (en) 2002-09-21 2011-08-30 Glaukos Corporation Ocular implant with anchoring mechanism and multiple outlets
US9168172B1 (en) * 2009-02-25 2015-10-27 Dr. John Berdahl Process for treating glaucoma
US9301875B2 (en) 2002-04-08 2016-04-05 Glaukos Corporation Ocular disorder treatment implants with multiple opening
US20160346125A1 (en) * 2003-11-14 2016-12-01 Transcend Medical, Inc. Ocular Pressure Regulation
US9827143B2 (en) 1999-04-26 2017-11-28 Glaukos Corporation Shunt device and method for treating ocular disorders
US9883969B2 (en) 2011-12-08 2018-02-06 Aquesys, Inc. Intrascleral shunt placement
US9980854B2 (en) 2010-11-15 2018-05-29 Aquesys, Inc. Shunt placement through the sclera
US9993368B2 (en) 2000-04-14 2018-06-12 Glaukos Corporation System and method for treating an ocular disorder
US10004638B2 (en) 2010-11-15 2018-06-26 Aquesys, Inc. Intraocular shunt delivery
US10080682B2 (en) 2011-12-08 2018-09-25 Aquesys, Inc. Intrascleral shunt placement
US10195079B2 (en) 2013-02-19 2019-02-05 Aquesys, Inc. Adjustable intraocular implant
US10307293B2 (en) 2010-11-15 2019-06-04 Aquesys, Inc. Methods for intraocular shunt placement
US10369048B2 (en) 2013-06-28 2019-08-06 Aquesys, Inc. Intraocular shunt implantation
US10463537B2 (en) 2015-06-03 2019-11-05 Aquesys Inc. Ab externo intraocular shunt placement
US10524959B2 (en) 2013-02-27 2020-01-07 Aquesys, Inc. Intraocular shunt implantation methods and devices
US10531983B2 (en) 2009-01-28 2020-01-14 Novartis Ag Ocular implant with stiffness qualities, methods of implantation and system
US10842671B2 (en) 2010-11-15 2020-11-24 Aquesys, Inc. Intraocular shunt placement in the suprachoroidal space
US10905590B2 (en) 2006-01-17 2021-02-02 Alcon Inc. Glaucoma treatment device
US10940041B1 (en) 2012-03-09 2021-03-09 John Berdahl Eye cavity pressure treatment using IOP or CSF
US11045355B2 (en) 2019-06-14 2021-06-29 Iantrek, Inc. Implantable biologic stent and system for biologic material shaping, preparation, and intraocular stenting for increased aqueous outflow and lowering of intraocular pressure
US11246753B2 (en) 2017-11-08 2022-02-15 Aquesys, Inc. Manually adjustable intraocular flow regulation
US11786122B2 (en) 2018-08-09 2023-10-17 Equinox Ophthalmic, Inc. Apparatus and methods to adjust ocular blood flow

Families Citing this family (105)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8313454B2 (en) 1997-11-20 2012-11-20 Optonol Ltd. Fluid drainage device, delivery device, and associated methods of use and manufacture
US7708711B2 (en) 2000-04-14 2010-05-04 Glaukos Corporation Ocular implant with therapeutic agents and methods thereof
US6962573B1 (en) 2000-10-18 2005-11-08 Wilcox Michael J C-shaped cross section tubular ophthalmic implant for reduction of intraocular pressure in glaucomatous eyes and method of use
JP4206272B2 (en) 2001-03-29 2009-01-07 サイナージィ ファーマスーティカルズ、インコーポレイテッド Guanylate cyclase receptor agonists for treating tissue inflammation and carcinogenesis
US7431710B2 (en) 2002-04-08 2008-10-07 Glaukos Corporation Ocular implants with anchors and methods thereof
US7678065B2 (en) 2001-05-02 2010-03-16 Glaukos Corporation Implant with intraocular pressure sensor for glaucoma treatment
US7951155B2 (en) 2002-03-15 2011-05-31 Glaukos Corporation Combined treatment for cataract and glaucoma treatment
US20040225250A1 (en) 2003-05-05 2004-11-11 Michael Yablonski Internal shunt and method for treating glaucoma
JP2008504938A (en) 2004-07-02 2008-02-21 レイザー,エリオット Treatment medium delivery apparatus and method for delivering treatment medium to eyes using the delivery apparatus
AR054647A1 (en) 2005-02-21 2007-07-11 Maldonado Bas Arturo DEVICE FOR WATER HUMOR DRAINAGE IN GLAUCOMA CASES
AU2016201445B2 (en) * 2006-01-17 2017-10-26 Alcon Inc. Glaucoma treatment device
US9084662B2 (en) * 2006-01-17 2015-07-21 Transcend Medical, Inc. Drug delivery treatment device
BRPI0709672B8 (en) 2006-03-31 2021-06-22 3088922 Inc ocular implant insertable into an ocular lumen and method of delivering a therapeutic agent to an eye
US7909789B2 (en) 2006-06-26 2011-03-22 Sight Sciences, Inc. Intraocular implants and methods and kits therefor
US8758290B2 (en) 2010-11-15 2014-06-24 Aquesys, Inc. Devices and methods for implanting a shunt in the suprachoroidal space
US8974511B2 (en) 2010-11-15 2015-03-10 Aquesys, Inc. Methods for treating closed angle glaucoma
US9095411B2 (en) 2010-11-15 2015-08-04 Aquesys, Inc. Devices for deploying intraocular shunts
US8852137B2 (en) 2010-11-15 2014-10-07 Aquesys, Inc. Methods for implanting a soft gel shunt in the suprachoroidal space
US8663303B2 (en) 2010-11-15 2014-03-04 Aquesys, Inc. Methods for deploying an intraocular shunt from a deployment device and into an eye
US20080108933A1 (en) * 2006-06-30 2008-05-08 Dao-Yi Yu Methods, Systems and Apparatus for Relieving Pressure in an Organ
US8308701B2 (en) 2010-11-15 2012-11-13 Aquesys, Inc. Methods for deploying intraocular shunts
US10085884B2 (en) 2006-06-30 2018-10-02 Aquesys, Inc. Intraocular devices
US8801766B2 (en) 2010-11-15 2014-08-12 Aquesys, Inc. Devices for deploying intraocular shunts
US8969514B2 (en) 2007-06-04 2015-03-03 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
CN101772513B (en) 2007-06-04 2013-11-13 协同医药品公司 Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
EP2173289A4 (en) 2007-07-17 2010-11-24 Transcend Medical Inc Ocular implant with hydrogel expansion capabilities
EP2205193A2 (en) 2007-09-07 2010-07-14 QLT Plug Delivery, Inc. Lacrimal implant detection
US20170360609A9 (en) 2007-09-24 2017-12-21 Ivantis, Inc. Methods and devices for increasing aqueous humor outflow
US20090082862A1 (en) 2007-09-24 2009-03-26 Schieber Andrew T Ocular Implant Architectures
US7740604B2 (en) 2007-09-24 2010-06-22 Ivantis, Inc. Ocular implants for placement in schlemm's canal
US8734377B2 (en) 2007-09-24 2014-05-27 Ivantis, Inc. Ocular implants with asymmetric flexibility
US8512404B2 (en) * 2007-11-20 2013-08-20 Ivantis, Inc. Ocular implant delivery system and method
US8808222B2 (en) 2007-11-20 2014-08-19 Ivantis, Inc. Methods and apparatus for delivering ocular implants into the eye
US8109896B2 (en) 2008-02-11 2012-02-07 Optonol Ltd. Devices and methods for opening fluid passageways
WO2009105573A1 (en) * 2008-02-19 2009-08-27 Cascade Ophthalmics Intraocular pressure attenuation devices and methods
JP2011513002A (en) 2008-03-05 2011-04-28 イバンティス インコーポレイテッド Method and apparatus for treating glaucoma
NZ588938A (en) * 2008-05-09 2013-03-28 Mati Therapeutics Inc Sustained release delivery of active agents to treat glaucoma and ocular hypertension
EP2296685B1 (en) 2008-06-04 2015-09-02 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
AU2009256157B2 (en) 2008-06-04 2014-12-18 Bausch Health Ireland Limited Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
ES2640867T3 (en) 2008-06-25 2017-11-07 Novartis Ag Eye implant with ability to change shape
JP2011528375A (en) 2008-07-16 2011-11-17 シナジー ファーマシューティカルズ インコーポレイテッド Guanylate cyclase agonists useful for the treatment of gastrointestinal disorders, inflammation, cancer, and other disorders
JP5964589B2 (en) 2008-12-03 2016-08-03 シナジー ファーマシューティカルズ インコーポレイテッド Preparation of guanylate cyclase C agonist and method of use thereof
CN102238926B (en) * 2008-12-05 2015-09-16 伊万提斯公司 For ocular implants being transported to the method and apparatus in eyes
WO2010093945A2 (en) 2009-02-13 2010-08-19 Glaukos Corporation Uveoscleral drug delivery implant and methods for implanting the same
AU2014280907B2 (en) * 2009-03-26 2017-02-09 Johnson & Johnson Surgical Vision, Inc. Glaucoma shunts with flow management and improved surgical performance
AU2010229789B2 (en) * 2009-03-26 2014-11-13 Johnson & Johnson Surgical Vision, Inc. Glaucoma shunts with flow management and improved surgical performance
US10206813B2 (en) 2009-05-18 2019-02-19 Dose Medical Corporation Implants with controlled drug delivery features and methods of using same
AU2010271218B2 (en) 2009-07-09 2017-02-02 Alcon Inc. Ocular implants and methods for delivering ocular implants into the eye
AU2010271274B2 (en) 2009-07-09 2015-05-21 Alcon Inc. Single operator device for delivering an ocular implant
US8535333B2 (en) 2009-07-29 2013-09-17 Transcend Medical, Inc. Ocular implant applier and methods of use
EP2490621A4 (en) 2009-10-23 2013-04-03 Ivantis Inc Ocular implant system and method
US20110105990A1 (en) * 2009-11-04 2011-05-05 Silvestrini Thomas A Zonal drug delivery device and method
EP2512389B1 (en) * 2009-12-16 2015-09-02 Allergan, Inc. Intracameral devices for sustained delivery
US8343106B2 (en) 2009-12-23 2013-01-01 Alcon Research, Ltd. Ophthalmic valved trocar vent
MX2012006598A (en) 2009-12-23 2012-06-19 Alcon Res Ltd Ophthalmic valved trocar cannula.
US8529492B2 (en) 2009-12-23 2013-09-10 Trascend Medical, Inc. Drug delivery devices and methods
WO2011089605A2 (en) 2010-01-22 2011-07-28 The Medical Research, Infrastructure, And Health Services Fund Of The Tel Aviv Medical Center Ocular shunt
US8529622B2 (en) 2010-02-05 2013-09-10 Sight Sciences, Inc. Intraocular implants and related kits and methods
WO2011163505A1 (en) 2010-06-23 2011-12-29 Ivantis, Inc. Ocular implants deployed in schlemm's canal of the eye
AU2011302006A1 (en) 2010-09-15 2013-03-07 Synergy Pharmaceuticals Inc. Formulations of guanylate cyclase C agonists and methods of use
US9616097B2 (en) 2010-09-15 2017-04-11 Synergy Pharmaceuticals, Inc. Formulations of guanylate cyclase C agonists and methods of use
US9668915B2 (en) 2010-11-24 2017-06-06 Dose Medical Corporation Drug eluting ocular implant
US10245178B1 (en) 2011-06-07 2019-04-02 Glaukos Corporation Anterior chamber drug-eluting ocular implant
US8657776B2 (en) 2011-06-14 2014-02-25 Ivantis, Inc. Ocular implants for delivery into the eye
US9974685B2 (en) 2011-08-29 2018-05-22 Mati Therapeutics Drug delivery system and methods of treating open angle glaucoma and ocular hypertension
CA2846384C (en) 2011-08-29 2020-12-15 Qlt Inc. Sustained release delivery of active agents to treat glaucoma and ocular hypertension
EP4193907A1 (en) 2011-09-13 2023-06-14 Glaukos Corporation Intraocular physiological sensor
US8765210B2 (en) 2011-12-08 2014-07-01 Aquesys, Inc. Systems and methods for making gelatin shunts
US8663150B2 (en) 2011-12-19 2014-03-04 Ivantis, Inc. Delivering ocular implants into the eye
EP4302734A3 (en) 2012-03-20 2024-03-20 Sight Sciences, Inc. Ocular delivery systems and methods
CA2868341C (en) 2012-03-26 2021-01-12 Glaukos Corporation System and method for delivering multiple ocular implants
US9358156B2 (en) 2012-04-18 2016-06-07 Invantis, Inc. Ocular implants for delivery into an anterior chamber of the eye
US10085633B2 (en) 2012-04-19 2018-10-02 Novartis Ag Direct visualization system for glaucoma treatment
US9241832B2 (en) 2012-04-24 2016-01-26 Transcend Medical, Inc. Delivery system for ocular implant
EP3228286A1 (en) 2012-09-17 2017-10-11 Novartis AG Expanding ocular impant devices
WO2014078288A1 (en) 2012-11-14 2014-05-22 Transcend Medical, Inc. Flow promoting ocular implant
US10617558B2 (en) 2012-11-28 2020-04-14 Ivantis, Inc. Apparatus for delivering ocular implants into an anterior chamber of the eye
US9125723B2 (en) 2013-02-19 2015-09-08 Aquesys, Inc. Adjustable glaucoma implant
US9730638B2 (en) 2013-03-13 2017-08-15 Glaukos Corporation Intraocular physiological sensor
US10517759B2 (en) 2013-03-15 2019-12-31 Glaukos Corporation Glaucoma stent and methods thereof for glaucoma treatment
US9708367B2 (en) 2013-03-15 2017-07-18 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase and their uses
US9592151B2 (en) 2013-03-15 2017-03-14 Glaukos Corporation Systems and methods for delivering an ocular implant to the suprachoroidal space within an eye
US9987163B2 (en) 2013-04-16 2018-06-05 Novartis Ag Device for dispensing intraocular substances
KR20150034010A (en) * 2013-09-25 2015-04-02 사회복지법인 삼성생명공익재단 An Apparatus for Treating Ocular Diseases Induced by Increased Intraocular Pressure
JP6574780B2 (en) 2013-11-14 2019-09-11 アクエシス, インコーポレイテッド Intraocular shunt inserter
US10493274B2 (en) 2013-12-09 2019-12-03 Purdue Research Foundation Optical pressure treatment through electrical stimulation
US20150342875A1 (en) 2014-05-29 2015-12-03 Dose Medical Corporation Implants with controlled drug delivery features and methods of using same
WO2016011056A1 (en) 2014-07-14 2016-01-21 Ivantis, Inc. Ocular implant delivery system and method
US10299958B2 (en) 2015-03-31 2019-05-28 Sight Sciences, Inc. Ocular delivery systems and methods
EP4265231A3 (en) 2015-08-14 2023-12-20 Alcon Inc. Ocular implant with pressure sensor
WO2017040853A1 (en) 2015-09-02 2017-03-09 Glaukos Corporation Drug delivery implants with bi-directional delivery capacity
CA3005151A1 (en) 2015-09-22 2017-03-30 Novartis Ag Ocular implant container
RU2618655C1 (en) * 2015-12-08 2017-05-05 Федеральное государственное автономное учреждение "Межотраслевой научно-технический комплекс "Микрохирургия глаза" имени академика С.Н. Федорова" Министерства здравоохранения Российской Федерации Glaucoma drainage
CA3022830A1 (en) 2016-04-20 2017-10-26 Harold Alexander Heitzmann Bioresorbable ocular drug delivery device
RU2018142990A (en) 2016-06-02 2020-06-05 Эквисис, Инк. INTERNAL EYE DELIVERY OF MEDICINES
GB201705177D0 (en) * 2017-03-31 2017-05-17 Sharma Anant Device to aid movement of substance from the eye
JP2020529274A (en) 2017-08-04 2020-10-08 パーデュー リサーチ ファウンデーション Multi-coil wireless power transfer assembly for wireless glaucoma treatment
DE102018203356A1 (en) 2018-03-07 2019-09-12 Carl Zeiss Meditec Ag Planning device and method for generating control data for an ophthalmic laser therapy device for structures for pressure-reducing bridging of the cornea
US10952898B2 (en) 2018-03-09 2021-03-23 Aquesys, Inc. Intraocular shunt inserter
US11135089B2 (en) 2018-03-09 2021-10-05 Aquesys, Inc. Intraocular shunt inserter
US11191962B2 (en) 2018-03-12 2021-12-07 Purdue Research Foundation Stimulus coil and pulse generator for wireless glaucoma therapy
US11672701B2 (en) 2018-10-25 2023-06-13 Amo Groningen B.V. Bleb control glaucoma shunts
US11504270B1 (en) 2019-09-27 2022-11-22 Sight Sciences, Inc. Ocular delivery systems and methods
JP2024503989A (en) 2021-01-11 2024-01-30 アルコン インコーポレイティド Systems and methods for viscoelastic delivery
WO2023102596A1 (en) * 2021-12-07 2023-06-15 Yu Xiang George Kong An ocular implant for the treatment of glaucoma

Citations (163)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3788327A (en) 1971-03-30 1974-01-29 H Donowitz Surgical implant device
US3915172A (en) 1970-05-27 1975-10-28 Ceskoslovenska Akademie Ved Capillary drain for glaucoma
US4037604A (en) 1976-01-05 1977-07-26 Newkirk John B Artifical biological drainage device
US4402681A (en) 1980-08-23 1983-09-06 Haas Joseph S Artificial implant valve for the regulation of intraocular pressure
US4457757A (en) 1981-07-20 1984-07-03 Molteno Anthony C B Device for draining aqueous humour
US4521210A (en) * 1982-12-27 1985-06-04 Wong Vernon G Eye implant for relieving glaucoma, and device and method for use therewith
US4554918A (en) 1982-07-28 1985-11-26 White Thomas C Ocular pressure relief device
US4604087A (en) 1985-02-26 1986-08-05 Joseph Neil H Aqueous humor drainage device
US4634418A (en) 1984-04-06 1987-01-06 Binder Perry S Hydrogel seton
US4722724A (en) 1986-06-23 1988-02-02 Stanley Schocket Anterior chamber tube shunt to an encircling band, and related surgical procedure
US4750901A (en) 1986-03-07 1988-06-14 Molteno Anthony C B Implant for drainage of aqueous humour
US4787885A (en) 1984-04-06 1988-11-29 Binder Perry S Hydrogel seton
US4826478A (en) 1986-06-23 1989-05-02 Stanley Schocket Anterior chamber tube shunt to an encircling band, and related surgical procedure
US4886488A (en) 1987-08-06 1989-12-12 White Thomas C Glaucoma drainage the lacrimal system and method
US4900300A (en) * 1987-07-06 1990-02-13 Lee David A Surgical instrument
EP0228185B1 (en) 1985-11-27 1990-07-25 Thomas C. White Tissue-implantable fluid-dissipating device
US4946436A (en) 1989-11-17 1990-08-07 Smith Stewart G Pressure-relieving device and process for implanting
US4968296A (en) 1989-12-20 1990-11-06 Robert Ritch Transscleral drainage implant device for the treatment of glaucoma
US5041081A (en) 1990-05-18 1991-08-20 Odrich Ronald B Ocular implant for controlling glaucoma
US5071408A (en) 1988-10-07 1991-12-10 Ahmed Abdul Mateen Medical valve
US5092837A (en) 1989-12-20 1992-03-03 Robert Ritch Method for the treatment of glaucoma
US5127901A (en) 1990-05-18 1992-07-07 Odrich Ronald B Implant with subconjunctival arch
US5171213A (en) 1991-08-14 1992-12-15 Price Jr Francis W Technique for fistulization of the eye and an eye filtration prosthesis useful therefor
US5178604A (en) 1990-05-31 1993-01-12 Iovision, Inc. Glaucoma implant
US5180362A (en) 1990-04-03 1993-01-19 Worst J G F Gonio seton
US5300020A (en) 1991-05-31 1994-04-05 Medflex Corporation Surgically implantable device for glaucoma relief
US5338291A (en) 1993-02-03 1994-08-16 Pudenz-Schulte Medical Research Corporation Glaucoma shunt and method for draining aqueous humor
US5342370A (en) 1993-03-19 1994-08-30 University Of Miami Method and apparatus for implanting an artifical meshwork in glaucoma surgery
US5346464A (en) 1992-03-10 1994-09-13 Camras Carl B Method and apparatus for reducing intraocular pressure
US5370607A (en) 1992-10-28 1994-12-06 Annuit Coeptis, Inc. Glaucoma implant device and method for implanting same
US5397300A (en) 1990-05-31 1995-03-14 Iovision, Inc. Glaucoma implant
US5433701A (en) 1994-12-21 1995-07-18 Rubinstein; Mark H. Apparatus for reducing ocular pressure
US5443505A (en) 1993-11-15 1995-08-22 Oculex Pharmaceuticals, Inc. Biocompatible ocular implants
US5454746A (en) 1994-01-06 1995-10-03 Meccano, S.A. Toy hand tool
US5476445A (en) 1990-05-31 1995-12-19 Iovision, Inc. Glaucoma implant with a temporary flow restricting seal
US5601094A (en) 1994-11-22 1997-02-11 Reiss; George R. Ophthalmic shunt
US5626558A (en) 1995-05-05 1997-05-06 Suson; John Adjustable flow rate glaucoma shunt and method of using same
US5676944A (en) 1993-10-06 1997-10-14 The Regents Of The University Of California Ocular therapy with homologous macrophages
US5702414A (en) 1995-05-14 1997-12-30 Optonol Ltd Method of implanting an intraocular implant
US5704907A (en) 1994-07-22 1998-01-06 Wound Healing Of Oklahoma Method and apparatus for lowering the intraocular pressure of an eye
US5741292A (en) 1995-10-26 1998-04-21 Eagle Vision Punctum dilating and plug inserting instrument with push-button plug release
US5743868A (en) 1994-02-14 1998-04-28 Brown; Reay H. Corneal pressure-regulating implant device
US5807302A (en) * 1996-04-01 1998-09-15 Wandel; Thaddeus Treatment of glaucoma
US5868697A (en) 1995-05-14 1999-02-09 Optonol Ltd. Intraocular implant
US5882327A (en) 1997-04-17 1999-03-16 Jacob; Jean T. Long-term glaucoma drainage implant
US5893837A (en) 1997-02-28 1999-04-13 Staar Surgical Company, Inc. Glaucoma drain implanting device and method
US5968058A (en) 1996-03-27 1999-10-19 Optonol Ltd. Device for and method of implanting an intraocular implant
US6007511A (en) 1991-05-08 1999-12-28 Prywes; Arnold S. Shunt valve and therapeutic delivery system for treatment of glaucoma and methods and apparatus for its installation
US6007510A (en) 1996-10-25 1999-12-28 Anamed, Inc. Implantable devices and methods for controlling the flow of fluids within the body
US6019786A (en) 1995-10-11 2000-02-01 Schneider (Usa) Inc Braided composite prosthesis
US6050970A (en) 1997-05-08 2000-04-18 Pharmacia & Upjohn Company Method and apparatus for inserting a glaucoma implant in an anterior and posterior segment of the eye
US6077299A (en) 1998-06-22 2000-06-20 Eyetronic, Llc Non-invasively adjustable valve implant for the drainage of aqueous humor in glaucoma
US6102045A (en) 1994-07-22 2000-08-15 Premier Laser Systems, Inc. Method and apparatus for lowering the intraocular pressure of an eye
US6142969A (en) 1996-10-25 2000-11-07 Anamed, Inc. Sutureless implantable device and method for treatment of glaucoma
US6186974B1 (en) 1997-01-10 2001-02-13 University College London And Moorfields Eye Hospital Nhs Trust Device for use in the eye
US6203513B1 (en) 1997-11-20 2001-03-20 Optonol Ltd. Flow regulating implant, method of manufacture, and delivery device
US6221078B1 (en) 1999-06-25 2001-04-24 Stephen S. Bylsma Surgical implantation apparatus
US6251090B1 (en) 1994-12-12 2001-06-26 Robert Logan Avery Intravitreal medicine delivery
US6261256B1 (en) 1996-12-20 2001-07-17 Abdul Mateen Ahmed Pocket medical valve & method
US6264668B1 (en) 1998-09-16 2001-07-24 Arnold S. Prywes Ophthalmologic instrument for producing a fistula in the sclera
US6331313B1 (en) 1999-10-22 2001-12-18 Oculex Pharmaceticals, Inc. Controlled-release biocompatible ocular drug delivery implant devices and methods
US20020013546A1 (en) 1997-08-15 2002-01-31 Grieshaber & Co. Ag Schaffhausen Method and device to improve aqueous humor drainage in an eye
EP1184010A2 (en) 2000-08-29 2002-03-06 Aixmed Gesellschaft für Medizintechnik mbH Aqueous humour drainage device
US6383219B1 (en) 1997-02-17 2002-05-07 Corneal Industrie Implant for deep sclerectomy
US20020072673A1 (en) 1999-12-10 2002-06-13 Yamamoto Ronald K. Treatment of ocular disease
US20020111608A1 (en) * 2001-01-18 2002-08-15 George Baerveldt Minimally invasive glaucoma surgical instrument and method
US20020128613A1 (en) 2001-03-12 2002-09-12 Masanari Nakayama Method of treating eye diseases of animals and artificial lacrimal duct used therefor
US6450984B1 (en) 1999-04-26 2002-09-17 Gmp Vision Solutions, Inc. Shunt device and method for treating glaucoma
US20020133168A1 (en) 2001-03-16 2002-09-19 Smedley Gregory T. Applicator and methods for placing a trabecular shunt for glaucoma treatment
US20020143284A1 (en) 2001-04-03 2002-10-03 Hosheng Tu Drug-releasing trabecular implant for glaucoma treatment
US6471666B1 (en) 2000-02-24 2002-10-29 Steven A. Odrich Injectable glaucoma device
US6471777B1 (en) 1998-10-20 2002-10-29 Murata Manufacturing Co., Ltd. Holder for electroless plating and method of electroless plating
US6533768B1 (en) 2000-04-14 2003-03-18 The Regents Of The University Of California Device for glaucoma treatment and methods thereof
EP1292256A1 (en) 2000-06-19 2003-03-19 Glaukos Corporation Stented trabecular shunt and methods thereof
US20030055372A1 (en) 1999-04-26 2003-03-20 Lynch Mary G. Shunt device and method for treating glaucoma
US6537568B2 (en) 1997-08-11 2003-03-25 Allergan, Inc. Implant device with a retinoid for improved biocompatibility
US20030060752A1 (en) 2000-04-14 2003-03-27 Olav Bergheim Glaucoma device and methods thereof
US6544208B2 (en) 2000-12-29 2003-04-08 C. Ross Ethier Implantable shunt device
US6544249B1 (en) 1996-11-29 2003-04-08 The Lions Eye Institute Of Western Australia Incorporated Biological microfistula tube and implantation method and apparatus
US6558342B1 (en) 1999-06-02 2003-05-06 Optonol Ltd. Flow control device, introducer and method of implanting
US20030097151A1 (en) 2001-10-25 2003-05-22 Smedley Gregory T. Apparatus and mitochondrial treatment for glaucoma
US20030097171A1 (en) 2001-11-20 2003-05-22 Elliott Christopher J. Stent with differential lengthening/shortening members
US6589203B1 (en) 2000-01-26 2003-07-08 Peter Mitrev Glaucoma drainage device implant
US20030135149A1 (en) 2002-01-13 2003-07-17 Cheryl Cullen Sinus valved glaucoma shunt
US6595945B2 (en) 2001-01-09 2003-07-22 J. David Brown Glaucoma treatment device and method
US20030181848A1 (en) 2000-04-14 2003-09-25 Bergheim Olav B. Implant with drug coating
US6648283B2 (en) 2001-07-06 2003-11-18 Joanne M. Chase Adjustable ornament display apparatus
US20030229303A1 (en) 2002-03-22 2003-12-11 Haffner David S. Expandable glaucoma implant and methods of use
US6666841B2 (en) 2001-05-02 2003-12-23 Glaukos Corporation Bifurcatable trabecular shunt for glaucoma treatment
US20030236483A1 (en) 2002-06-25 2003-12-25 Ren David H Dual drainage ocular shunt for glaucoma
US6676607B2 (en) 2000-01-03 2004-01-13 The Johns Hopkins University Intraoperative microsurgical ultrasonic device and methods related thereto
US20040024345A1 (en) 2002-04-19 2004-02-05 Morteza Gharib Glaucoma implant with valveless flow bias
US6699210B2 (en) 1999-04-27 2004-03-02 The Arizona Board Of Regents Glaucoma shunt and a method of making and surgically implanting the same
US6699211B2 (en) 2000-08-22 2004-03-02 James A. Savage Method and apparatus for treatment of glaucoma
US20040050392A1 (en) 2001-08-28 2004-03-18 Hosheng Tu Glaucoma stent for treating glaucoma and methods of use
US6719750B2 (en) 2000-08-30 2004-04-13 The Johns Hopkins University Devices for intraocular drug delivery
US6730056B1 (en) 2000-09-21 2004-05-04 Motorola, Inc. Eye implant for treating glaucoma and method for manufacturing same
US6741666B1 (en) 1999-02-24 2004-05-25 Canon Kabushiki Kaisha Device and method for transforming a digital signal
US20040102729A1 (en) 2002-04-08 2004-05-27 David Haffner Devices and methods for glaucoma treatment
US20040111050A1 (en) 2000-04-14 2004-06-10 Gregory Smedley Implantable ocular pump to reduce intraocular pressure
US20040127843A1 (en) 2000-04-14 2004-07-01 Hosheng Tu Glaucoma implant with therapeutic agents
WO2004056294A1 (en) 2002-12-19 2004-07-08 Wound Healing Of Oklahoma, Inc Device for ocular aqueous drainage
WO2004026347A9 (en) 2002-09-17 2004-07-22 Iscience Surgical Corp Apparatus and method for surgical bypass of aqueous humor
WO2004060219A1 (en) 2002-12-27 2004-07-22 Japan Science And Technology Agency Aqueous humor drainage implant for treating glaucoma
US20040147870A1 (en) 2002-04-08 2004-07-29 Burns Thomas W. Glaucoma treatment kit
US20040193262A1 (en) 2003-03-29 2004-09-30 Shadduck John H. Implants for treating ocular hypertension, methods of use and methods of fabrication
US20040193095A1 (en) 2003-03-29 2004-09-30 Shadduck John H. Implants for treating ocular hypertension, methods of use and methods of fabrication
US20040210181A1 (en) 2001-04-26 2004-10-21 Clemens Vass Drainage implant for draining aqueous humour from the anterior aqueous chamber of the eye into schlemm's canal
US20040216749A1 (en) 2003-01-23 2004-11-04 Hosheng Tu Vasomodulation during glaucoma surgery
US20040225250A1 (en) 2003-05-05 2004-11-11 Michael Yablonski Internal shunt and method for treating glaucoma
US20040236343A1 (en) 2003-05-23 2004-11-25 Taylor Jon B. Insertion tool for ocular implant and method for using same
US20040254521A1 (en) 2003-06-16 2004-12-16 Solx, Inc. Shunt for the treatment of glaucoma
US20040254517A1 (en) 2003-02-18 2004-12-16 Hugo Quiroz-Mercado Methods and devices for draining fluids and lowering intraocular pressure
WO2005016148A1 (en) 2003-08-14 2005-02-24 Andrzej Krysztof Stethoscope with identifying-personalizing ring
US20050049578A1 (en) 2000-04-14 2005-03-03 Hosheng Tu Implantable ocular pump to reduce intraocular pressure
US6881197B1 (en) 1996-10-25 2005-04-19 Anamed, Inc. Sutureless implantable device and method for treatment of glaucoma
US6881198B2 (en) 2001-01-09 2005-04-19 J. David Brown Glaucoma treatment device and method
WO2004062469A3 (en) 2003-01-13 2005-05-12 Clarity Corp Sinus valved glaucoma shunt
US20050107734A1 (en) 2003-11-14 2005-05-19 Coroneo Minas T. Ocular pressure regulation
US20050119636A1 (en) 2001-05-02 2005-06-02 David Haffner Implant with intraocular pressure sensor for glaucoma treatment
US20050119737A1 (en) 2000-01-12 2005-06-02 Bene Eric A. Ocular implant and methods for making and using same
US20050125003A1 (en) 2003-12-05 2005-06-09 Leonard Pinchuk Glaucoma implant device
US20050143817A1 (en) 2003-11-10 2005-06-30 Angiotech International Ag Medical implants and anti-scarring agents
WO2004043231A3 (en) 2002-11-06 2005-07-21 Gmp Vision Solutions Inc Storage apparatus for surgical implant device
US20050192527A1 (en) 2001-05-02 2005-09-01 Morteza Gharib Glaucoma implant with extending members
US6939298B2 (en) 2002-02-28 2005-09-06 Gmp Vision Solutions, Inc Device and method for monitoring aqueous flow within the eye
US20050197613A1 (en) 2004-03-02 2005-09-08 Sniegowski Jeffry J. Implant having MEMS flow module with movable, flow-controlling baffle
US20050232972A1 (en) 2004-04-15 2005-10-20 Steven Odrich Drug delivery via punctal plug
US20050244462A1 (en) 2004-04-30 2005-11-03 Allergan, Inc. Devices and methods for treating a mammalian eye
US6962573B1 (en) 2000-10-18 2005-11-08 Wilcox Michael J C-shaped cross section tubular ophthalmic implant for reduction of intraocular pressure in glaucomatous eyes and method of use
US20050250788A1 (en) 2004-01-30 2005-11-10 Hosheng Tu Aqueous outflow enhancement with vasodilated aqueous cavity
WO2005107845A1 (en) 2004-04-29 2005-11-17 Iscience Interventional Corporation Apparatus and method for ocular treatment
US20050267398A1 (en) 2004-05-27 2005-12-01 Dimitri Protopsaltis Glaucoma shunt
US20050266047A1 (en) 2002-04-08 2005-12-01 Hosheng Tu Injectable glaucoma implants with multiple openings
US20050267397A1 (en) 2004-05-20 2005-12-01 Ajay Bhalla Aqueous drainage and flow regulating implant
US20050271704A1 (en) 2002-04-08 2005-12-08 Hosheng Tu Injectable glaucoma implants with multiple openings
US20050273033A1 (en) 2002-05-29 2005-12-08 Grahn Bruce H Shunt and method treatment of glaucoma
US20050277864A1 (en) 2000-04-14 2005-12-15 David Haffner Injectable gel implant for glaucoma treatment
WO2005107664A3 (en) 2004-04-29 2005-12-22 Iscience Surgical Corp Apparatus and method for surgical enhancement of aqueous humor drainage
US20050283108A1 (en) 2004-06-10 2005-12-22 Savage James A Apparatus and method for non-pharmacological treatment of glaucoma and lowering intraocular pressure
US20050288617A1 (en) 2004-06-25 2005-12-29 Ira Yaron Flow regulating implants
US6989007B2 (en) 2001-02-21 2006-01-24 Solx, Inc. Devices and techniques for treating glaucoma
US20060020248A1 (en) 2004-07-26 2006-01-26 Prescott Anthony D Lacrimal insert having reservoir with controlled release of medication and method of manufacturing the same
WO2006012421A2 (en) 2004-07-20 2006-02-02 St. Jude Medical, Atrial Fibrillation Division, Inc. Steerable catheter with hydraulic or pneumatic actuator
US20060036207A1 (en) 2004-02-24 2006-02-16 Koonmen James P System and method for treating glaucoma
US20060032507A1 (en) 2004-08-11 2006-02-16 Hosheng Tu Contrast-enhanced ocular imaging
US20060069340A1 (en) 2003-06-16 2006-03-30 Solx, Inc. Shunt for the treatment of glaucoma
US7041077B2 (en) 2002-07-19 2006-05-09 Yale University Uveoscleral drainage device
US20060116626A1 (en) 2002-03-07 2006-06-01 Gregory Smedley Fluid infusion methods for glaucoma treatment
US20060173397A1 (en) 2004-11-23 2006-08-03 Hosheng Tu Ophthalmology implants and methods of manufacture
US7090681B2 (en) * 2002-09-18 2006-08-15 Allergan, Inc. Methods and apparatus for delivery of ocular implants
US7094225B2 (en) 2001-05-03 2006-08-22 Glaukos Corporation Medical device and methods of use of glaucoma treatment
US20060200113A1 (en) 2002-03-07 2006-09-07 David Haffner Liquid jet for glaucoma treatment
US7135009B2 (en) 2001-04-07 2006-11-14 Glaukos Corporation Glaucoma stent and methods thereof for glaucoma treatment
US7163543B2 (en) 2001-11-08 2007-01-16 Glaukos Corporation Combined treatment for cataract and glaucoma treatment
US7192412B1 (en) 2002-09-14 2007-03-20 Glaukos Corporation Targeted stent placement and multi-stent therapy
US20070118147A1 (en) 2002-03-15 2007-05-24 Smedley Gregory T Combined treatment for cataract and glaucoma treatment
US20070191863A1 (en) 2006-01-17 2007-08-16 De Juan Eugene Jr Glaucoma Treatment Device
WO2007115259A2 (en) 2006-03-31 2007-10-11 Qlt Plug Delivery, Inc. Nasolacrimal drainage system implants for drug therapy
US20070293807A1 (en) 2006-05-01 2007-12-20 Lynch Mary G Dual drainage pathway shunt device and method for treating glaucoma
WO2008061043A2 (en) 2006-11-10 2008-05-22 Glaukos Corporation Uveoscleral shunt and methods for implanting same
EP1545655B1 (en) 2002-08-08 2008-12-31 Glaukos Corporation Implantable ocular pump to reduce intraocular pressure
US7488303B1 (en) 2002-09-21 2009-02-10 Glaukos Corporation Ocular implant with anchor and multiple openings

Family Cites Families (96)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US666841A (en) * 1900-05-07 1901-01-29 John A Hill Mechanism for mixing and measuring materials.
US2990670A (en) 1957-03-07 1961-07-04 North American Rayon Corp Yarn crimping and texturing apparatus
US3439675A (en) 1966-06-14 1969-04-22 Becton Dickinson Co Deformable needle assembly
CS152018B1 (en) 1970-05-27 1973-12-19
DK126413B (en) * 1971-09-22 1973-07-16 Astra Sjuco Ab Venous stripper.
GB2101891A (en) * 1981-07-18 1983-01-26 Anthony Christopher Be Molteno Device for draining aqueous humour
FI67916C (en) 1982-08-03 1985-06-10 Tampella Oy Ab ANORDNING FOER FOERHANDSFAESTNING AV EN STAOLVAJERBULT
US4863457A (en) 1986-11-24 1989-09-05 Lee David A Drug delivery device
US4846172A (en) 1987-05-26 1989-07-11 Berlin Michael S Laser-delivery eye-treatment method
AU2308988A (en) 1987-08-06 1989-03-01 Thomas C. White Glaucoma drainage in the lacrimal system
US4936825A (en) 1988-04-11 1990-06-26 Ungerleider Bruce A Method for reducing intraocular pressure caused by glaucoma
US5817075A (en) 1989-08-14 1998-10-06 Photogenesis, Inc. Method for preparation and transplantation of planar implants and surgical instrument therefor
SG49267A1 (en) 1989-08-14 1998-05-18 Photogenesis Inc Surgical instrument and cell isolation and transplantation
US5749879A (en) 1989-08-16 1998-05-12 Medtronic, Inc. Device or apparatus for manipulating matter
USRE35390E (en) 1989-11-17 1996-12-03 Smith; Stewart G. Pressure relieving device and process for implanting
US5073163A (en) 1990-01-29 1991-12-17 Lippman Myron E Apparatus for treating glaucoma
SE9000491L (en) 1990-02-12 1991-08-13 Atos Medical Ab GLAUCOMA VALVE
RU2056818C1 (en) 1990-04-28 1996-03-27 Межотраслевой научно-технический комплекс "Микрохирургия глаза" Device for strengthening erection
US5326345A (en) 1991-08-14 1994-07-05 Price Jr Francis W Eye filtration prostheses
RU2018289C1 (en) 1992-03-19 1994-08-30 Межотраслевой научно-технический комплекс "Микрохирургия глаза" Method of treatment of secondary glaucoma in children
US5284476A (en) 1992-03-20 1994-02-08 Koch Paul S Nuclear hydrolysis cannula
WO1994002081A1 (en) 1992-07-16 1994-02-03 Wong Vernon G Eye implant suitable for relief of glaucoma
WO1994013234A1 (en) 1992-12-17 1994-06-23 Michael Andrew Coote Implant device and method for treatment of glaucoma
FR2710269A1 (en) 1993-09-22 1995-03-31 Voir Vivre Implantable device for the treatment of edemas.
US5423777A (en) 1993-10-27 1995-06-13 Tajiri; Akira Punctum plug
IL109499A (en) * 1994-05-02 1998-01-04 Univ Ramot Implant device for draining excess intraocular fluid
RU2074686C1 (en) 1994-08-10 1997-03-10 Волгоградский филиал Межотраслевого научно-технического комплекса "Микрохирургия глаза" Method to treat glaucoma
RU2074687C1 (en) 1994-08-10 1997-03-10 Волгоградский филиал Межотраслевого научно-технического комплекса "Микрохирургия глаза" Method to treat glaucoma
US5569197A (en) 1994-12-21 1996-10-29 Schneider (Usa) Inc Drug delivery guidewire
US5558630A (en) 1994-12-30 1996-09-24 Fisher; Bret L. Intrascleral implant and method for the regulation of intraocular pressure
WO1996020742A1 (en) 1995-01-06 1996-07-11 Wong Vernon G Improve eye implant for relief of glaucoma
US5792075A (en) 1995-04-11 1998-08-11 Schneider (Europe) A.G. Method and apparatus for extending the length of a guide wire
US20040148022A1 (en) 1996-03-18 2004-07-29 Eggleston Harry C. Modular intraocular implant
US6258083B1 (en) 1996-03-29 2001-07-10 Eclipse Surgical Technologies, Inc. Viewing surgical scope for minimally invasive procedures
US6152918A (en) 1996-04-05 2000-11-28 Eclipse Surgical Technologies, Inc. Laser device with auto-piercing tip for myocardial revascularization procedures
CN1225027A (en) 1996-05-20 1999-08-04 佩尔库瑟吉公司 Low profile catheter valve
US6786888B1 (en) 1996-05-20 2004-09-07 Medtronic Ave, Inc. Low profile catheter for emboli protection
US5807244A (en) 1996-11-15 1998-09-15 Barot; Jagdish Shantilal Single use disposable iris retractor
US5941250A (en) 1996-11-21 1999-08-24 University Of Louisville Research Foundation Inc. Retinal tissue implantation method
US5713844A (en) 1997-01-10 1998-02-03 Peyman; Gholam A. Device and method for regulating intraocular pressure
US5752928A (en) 1997-07-14 1998-05-19 Rdo Medical, Inc. Glaucoma pressure regulator
US8313454B2 (en) 1997-11-20 2012-11-20 Optonol Ltd. Fluid drainage device, delivery device, and associated methods of use and manufacture
US6050999A (en) 1997-12-18 2000-04-18 Keravision, Inc. Corneal implant introducer and method of use
US6376642B1 (en) * 1998-07-07 2002-04-23 Atofina Chemicals, Inc. Polyester polycondensation with lithium titanyl oxalate catalyst
DE19840047B4 (en) 1998-09-02 2004-07-08 Neuhann, Thomas, Prof.Dr.med. Device for the targeted improvement and / or permanent guarantee of the permeability for eye chamber water through the trabecular mechanism in the Schlemm's Canal
US6270472B1 (en) 1998-12-29 2001-08-07 University Of Pittsburgh Of The Commonwealth System Of Higher Education Apparatus and a method for automatically introducing implants into soft tissue with adjustable spacing
US8702727B1 (en) 1999-02-01 2014-04-22 Hologic, Inc. Delivery catheter with implant ejection mechanism
US6699285B2 (en) 1999-09-24 2004-03-02 Scieran Technologies, Inc. Eye endoplant for the reattachment of a retina
AU8026600A (en) 1999-10-15 2001-04-30 Deschutes Medical Products, Inc. Brachytherapy instrument and methods
RU2157678C1 (en) 1999-12-22 2000-10-20 Макашова Надежда Васильевна Surgical method for treating the cases of glaucoma
US6726676B2 (en) 2000-01-05 2004-04-27 Grieshaber & Co. Ag Schaffhausen Method of and device for improving the flow of aqueous humor within the eye
US6375642B1 (en) 2000-02-15 2002-04-23 Grieshaber & Co. Ag Schaffhausen Method of and device for improving a drainage of aqueous humor within the eye
US7077848B1 (en) 2000-03-11 2006-07-18 John Hopkins University Sutureless occular surgical methods and instruments for use in such methods
US6984230B2 (en) 2000-04-07 2006-01-10 Synergetics, Inc. Directional laser probe
CA2446143C (en) 2000-05-19 2010-01-19 Michael S. Berlin Delivery system and method of use for the eye
US6561974B1 (en) 2000-05-31 2003-05-13 Grieshaber & Co. Ag Schaffhausen Device for use in a surgical procedure on an eye of a living being, and method of retracting the iris
FR2813521B1 (en) 2000-09-01 2003-06-13 Ioltechnologie Production GLAUCOME DRAIN
GB0025611D0 (en) 2000-10-19 2000-12-06 Duckworth & Kent Ltd Tablet inserters
WO2002036052A1 (en) 2000-11-01 2002-05-10 Glaukos Corporation Glaucoma treatment device
US20030028228A1 (en) 2001-03-30 2003-02-06 Sand Bruce J. Treatment of collagen
DE10118835C2 (en) * 2001-04-17 2003-03-13 Bruker Biospin Ag Faellanden Superconducting resonators for applications in NMR
WO2002102274A2 (en) 2001-05-01 2002-12-27 Glaukos Corporation Glaucoma device and methods thereof
EP1418864A4 (en) 2001-08-03 2009-07-01 Research Technologies Glaucoma Method and intra sclera implant for treatment of glaucoma and presbyopia
US6911016B2 (en) 2001-08-06 2005-06-28 Scimed Life Systems, Inc. Guidewire extension system
CA2457137A1 (en) 2001-08-16 2003-02-27 Gmp Vision Solutions, Inc. Improved shunt device and method for treating glaucoma
PT1420716E (en) 2001-08-29 2012-11-21 Ricardo A P De Carvalho An implantable and sealable system for unidirectional delivery of therapeutic agents to targeted tissues
US20030093084A1 (en) 2001-11-13 2003-05-15 Optonol Ltd. Delivery devices for flow regulating implants
US8491549B2 (en) 2001-11-21 2013-07-23 Iscience Interventional Corporation Ophthalmic microsurgical system
JP4499327B2 (en) 2001-12-06 2010-07-07 松崎 浩巳 Diameter expansion instrument and surgical instrument set
US6770093B2 (en) 2002-01-23 2004-08-03 Ophtec B.V. Fixation of an intraocular implant to the iris
US20050085892A1 (en) 2002-05-01 2005-04-21 Olympus Corporation Stent delivery device
IL149706A0 (en) 2002-05-16 2002-11-10 Dolopaz Technologies Ltd Multipurpose fluid jet surgical device
WO2005105197A2 (en) 2003-02-28 2005-11-10 Gmp Vision Solutions, Inc. Indwelling shunt device and methods for treating glaucoma
US8404269B2 (en) 2003-04-11 2013-03-26 Michael Snyder Sustained release implantable eye device
US7972616B2 (en) 2003-04-17 2011-07-05 Nanosys, Inc. Medical device applications of nanostructured surfaces
CA2528060C (en) 2003-06-10 2012-12-11 Neomedix Corporation Device and methods useable for treatment of glaucoma and other surgical procedures
WO2007035895A2 (en) 2005-09-21 2007-03-29 Cook Incorporated Endoluminal stent graft delivery assembly
US9084662B2 (en) 2006-01-17 2015-07-21 Transcend Medical, Inc. Drug delivery treatment device
US20120123316A1 (en) * 2010-11-15 2012-05-17 Aquesys, Inc. Intraocular shunts for placement in the intra-tenon's space
US20080108933A1 (en) * 2006-06-30 2008-05-08 Dao-Yi Yu Methods, Systems and Apparatus for Relieving Pressure in an Organ
US20090036840A1 (en) 2006-11-22 2009-02-05 Cytyc Corporation Atraumatic ball tip and side wall opening
EP2173289A4 (en) 2007-07-17 2010-11-24 Transcend Medical Inc Ocular implant with hydrogel expansion capabilities
AU2008300013A1 (en) 2007-09-07 2009-03-19 Qlt Inc. Drug cores for sustained release of therapeutic agents
ES2640867T3 (en) 2008-06-25 2017-11-07 Novartis Ag Eye implant with ability to change shape
EP2548538B1 (en) 2009-01-28 2020-04-01 Alcon Inc. Implantation systems for ocular implants with stiffness qualities
US8535333B2 (en) 2009-07-29 2013-09-17 Transcend Medical, Inc. Ocular implant applier and methods of use
PL2600930T3 (en) 2010-08-05 2021-09-06 Forsight Vision4, Inc. Injector apparatus for drug delivery
WO2013059678A1 (en) 2011-10-21 2013-04-25 Transcend Medical, Inc. Gonio lens system with stabilization mechanism
US10085633B2 (en) 2012-04-19 2018-10-02 Novartis Ag Direct visualization system for glaucoma treatment
US9241832B2 (en) 2012-04-24 2016-01-26 Transcend Medical, Inc. Delivery system for ocular implant
EP3228286A1 (en) 2012-09-17 2017-10-11 Novartis AG Expanding ocular impant devices
WO2014078288A1 (en) 2012-11-14 2014-05-22 Transcend Medical, Inc. Flow promoting ocular implant
US10154924B2 (en) 2013-01-28 2018-12-18 Novartis Ag Schlemm's canal devices and method for improving fluid flow
US9987163B2 (en) 2013-04-16 2018-06-05 Novartis Ag Device for dispensing intraocular substances
US20140323995A1 (en) 2013-04-24 2014-10-30 Transcend Medical, Inc. Targeted Drug Delivery Devices and Methods
WO2014190029A1 (en) 2013-05-21 2014-11-27 Transcend Medical, Inc. Flow promoting ocular implant device and methods

Patent Citations (252)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3915172A (en) 1970-05-27 1975-10-28 Ceskoslovenska Akademie Ved Capillary drain for glaucoma
US3788327A (en) 1971-03-30 1974-01-29 H Donowitz Surgical implant device
US4037604A (en) 1976-01-05 1977-07-26 Newkirk John B Artifical biological drainage device
US4402681A (en) 1980-08-23 1983-09-06 Haas Joseph S Artificial implant valve for the regulation of intraocular pressure
US4457757A (en) 1981-07-20 1984-07-03 Molteno Anthony C B Device for draining aqueous humour
US4554918A (en) 1982-07-28 1985-11-26 White Thomas C Ocular pressure relief device
US4521210A (en) * 1982-12-27 1985-06-04 Wong Vernon G Eye implant for relieving glaucoma, and device and method for use therewith
US4634418A (en) 1984-04-06 1987-01-06 Binder Perry S Hydrogel seton
US4787885A (en) 1984-04-06 1988-11-29 Binder Perry S Hydrogel seton
US4604087A (en) 1985-02-26 1986-08-05 Joseph Neil H Aqueous humor drainage device
EP0228185B1 (en) 1985-11-27 1990-07-25 Thomas C. White Tissue-implantable fluid-dissipating device
US4750901A (en) 1986-03-07 1988-06-14 Molteno Anthony C B Implant for drainage of aqueous humour
US4722724A (en) 1986-06-23 1988-02-02 Stanley Schocket Anterior chamber tube shunt to an encircling band, and related surgical procedure
US4826478A (en) 1986-06-23 1989-05-02 Stanley Schocket Anterior chamber tube shunt to an encircling band, and related surgical procedure
US4900300A (en) * 1987-07-06 1990-02-13 Lee David A Surgical instrument
US4886488A (en) 1987-08-06 1989-12-12 White Thomas C Glaucoma drainage the lacrimal system and method
US5071408A (en) 1988-10-07 1991-12-10 Ahmed Abdul Mateen Medical valve
US4946436A (en) 1989-11-17 1990-08-07 Smith Stewart G Pressure-relieving device and process for implanting
US4968296A (en) 1989-12-20 1990-11-06 Robert Ritch Transscleral drainage implant device for the treatment of glaucoma
US5092837A (en) 1989-12-20 1992-03-03 Robert Ritch Method for the treatment of glaucoma
US5180362A (en) 1990-04-03 1993-01-19 Worst J G F Gonio seton
US5127901A (en) 1990-05-18 1992-07-07 Odrich Ronald B Implant with subconjunctival arch
US5041081A (en) 1990-05-18 1991-08-20 Odrich Ronald B Ocular implant for controlling glaucoma
US5178604A (en) 1990-05-31 1993-01-12 Iovision, Inc. Glaucoma implant
US5476445A (en) 1990-05-31 1995-12-19 Iovision, Inc. Glaucoma implant with a temporary flow restricting seal
US5397300A (en) 1990-05-31 1995-03-14 Iovision, Inc. Glaucoma implant
US5558629A (en) 1990-05-31 1996-09-24 Iovision, Inc. Glaucoma implant
US6007511A (en) 1991-05-08 1999-12-28 Prywes; Arnold S. Shunt valve and therapeutic delivery system for treatment of glaucoma and methods and apparatus for its installation
US5300020A (en) 1991-05-31 1994-04-05 Medflex Corporation Surgically implantable device for glaucoma relief
US5171213A (en) 1991-08-14 1992-12-15 Price Jr Francis W Technique for fistulization of the eye and an eye filtration prosthesis useful therefor
US5346464A (en) 1992-03-10 1994-09-13 Camras Carl B Method and apparatus for reducing intraocular pressure
US5370607A (en) 1992-10-28 1994-12-06 Annuit Coeptis, Inc. Glaucoma implant device and method for implanting same
US5338291A (en) 1993-02-03 1994-08-16 Pudenz-Schulte Medical Research Corporation Glaucoma shunt and method for draining aqueous humor
US5342370A (en) 1993-03-19 1994-08-30 University Of Miami Method and apparatus for implanting an artifical meshwork in glaucoma surgery
US5651782A (en) 1993-03-19 1997-07-29 University Of Miami Method and apparatus for implanting an artificial meshwork in glaucoma surgery
US5676944A (en) 1993-10-06 1997-10-14 The Regents Of The University Of California Ocular therapy with homologous macrophages
US5443505A (en) 1993-11-15 1995-08-22 Oculex Pharmaceuticals, Inc. Biocompatible ocular implants
US5454746A (en) 1994-01-06 1995-10-03 Meccano, S.A. Toy hand tool
US5743868A (en) 1994-02-14 1998-04-28 Brown; Reay H. Corneal pressure-regulating implant device
US5704907A (en) 1994-07-22 1998-01-06 Wound Healing Of Oklahoma Method and apparatus for lowering the intraocular pressure of an eye
US6102045A (en) 1994-07-22 2000-08-15 Premier Laser Systems, Inc. Method and apparatus for lowering the intraocular pressure of an eye
US5601094A (en) 1994-11-22 1997-02-11 Reiss; George R. Ophthalmic shunt
US6251090B1 (en) 1994-12-12 2001-06-26 Robert Logan Avery Intravitreal medicine delivery
US5433701A (en) 1994-12-21 1995-07-18 Rubinstein; Mark H. Apparatus for reducing ocular pressure
US5626558A (en) 1995-05-05 1997-05-06 Suson; John Adjustable flow rate glaucoma shunt and method of using same
US6508779B1 (en) 1995-05-05 2003-01-21 John Suson Adjustable flow rate glaucoma shunt and method of using same
US5868697A (en) 1995-05-14 1999-02-09 Optonol Ltd. Intraocular implant
EP1473004A2 (en) 1995-05-14 2004-11-03 Optonol Ltd. Ophtalmic implant for treating glaucoma and delivery device
US20020177856A1 (en) 1995-05-14 2002-11-28 Jacob Richter Intraocular implant, delivery device, and method of implantation
US20040088048A1 (en) 1995-05-14 2004-05-06 Jacob Richter Intraocular implant, delivery device, and method of implantation
US6468283B1 (en) 1995-05-14 2002-10-22 Optonol, Ltd. Method of regulating pressure with an intraocular implant
US5702414A (en) 1995-05-14 1997-12-30 Optonol Ltd Method of implanting an intraocular implant
US6019786A (en) 1995-10-11 2000-02-01 Schneider (Usa) Inc Braided composite prosthesis
US5741292A (en) 1995-10-26 1998-04-21 Eagle Vision Punctum dilating and plug inserting instrument with push-button plug release
US5968058A (en) 1996-03-27 1999-10-19 Optonol Ltd. Device for and method of implanting an intraocular implant
US5807302A (en) * 1996-04-01 1998-09-15 Wandel; Thaddeus Treatment of glaucoma
US6881197B1 (en) 1996-10-25 2005-04-19 Anamed, Inc. Sutureless implantable device and method for treatment of glaucoma
US20050182350A1 (en) 1996-10-25 2005-08-18 Alok Nigam Sutureless implantable device and method for treatment of glaucoma
US6007510A (en) 1996-10-25 1999-12-28 Anamed, Inc. Implantable devices and methods for controlling the flow of fluids within the body
US6142969A (en) 1996-10-25 2000-11-07 Anamed, Inc. Sutureless implantable device and method for treatment of glaucoma
US6544249B1 (en) 1996-11-29 2003-04-08 The Lions Eye Institute Of Western Australia Incorporated Biological microfistula tube and implantation method and apparatus
US6261256B1 (en) 1996-12-20 2001-07-17 Abdul Mateen Ahmed Pocket medical valve & method
US6186974B1 (en) 1997-01-10 2001-02-13 University College London And Moorfields Eye Hospital Nhs Trust Device for use in the eye
US6383219B1 (en) 1997-02-17 2002-05-07 Corneal Industrie Implant for deep sclerectomy
US5893837A (en) 1997-02-28 1999-04-13 Staar Surgical Company, Inc. Glaucoma drain implanting device and method
US5882327A (en) 1997-04-17 1999-03-16 Jacob; Jean T. Long-term glaucoma drainage implant
US6050970A (en) 1997-05-08 2000-04-18 Pharmacia & Upjohn Company Method and apparatus for inserting a glaucoma implant in an anterior and posterior segment of the eye
US6537568B2 (en) 1997-08-11 2003-03-25 Allergan, Inc. Implant device with a retinoid for improved biocompatibility
US20020013546A1 (en) 1997-08-15 2002-01-31 Grieshaber & Co. Ag Schaffhausen Method and device to improve aqueous humor drainage in an eye
US6203513B1 (en) 1997-11-20 2001-03-20 Optonol Ltd. Flow regulating implant, method of manufacture, and delivery device
US6510600B2 (en) 1997-11-20 2003-01-28 Optonol, Ltd. Method for manufacturing a flow regulating implant
US6077299A (en) 1998-06-22 2000-06-20 Eyetronic, Llc Non-invasively adjustable valve implant for the drainage of aqueous humor in glaucoma
US6264668B1 (en) 1998-09-16 2001-07-24 Arnold S. Prywes Ophthalmologic instrument for producing a fistula in the sclera
US6471777B1 (en) 1998-10-20 2002-10-29 Murata Manufacturing Co., Ltd. Holder for electroless plating and method of electroless plating
US6741666B1 (en) 1999-02-24 2004-05-25 Canon Kabushiki Kaisha Device and method for transforming a digital signal
US20070088432A1 (en) 1999-04-26 2007-04-19 Kenneth Solovay Indwelling shunt device and methods for treating glaucoma
EP1477146B1 (en) 1999-04-26 2009-08-26 Glaukos Corporation Shunt device for treating glaucoma
US20050119601A9 (en) 1999-04-26 2005-06-02 Lynch Mary G. Shunt device and method for treating glaucoma
EP1173126B1 (en) 1999-04-26 2007-12-12 Gmp Vision Solutions, Inc. Inflatable device for treating glaucoma
US20030236484A1 (en) 1999-04-26 2003-12-25 Gmp Vision Solutions, Inc. Inflatable device and method for treating glaucoma
US6524275B1 (en) 1999-04-26 2003-02-25 Gmp Vision Solutions, Inc. Inflatable device and method for treating glaucoma
US20050090806A1 (en) 1999-04-26 2005-04-28 Gmp Vision Solutions Inc. Shunt device and method for treating glaucoma
US20050090807A1 (en) 1999-04-26 2005-04-28 Gmp Vision Solutions, Inc. Shunt device and method for treating glaucoma
US20030055372A1 (en) 1999-04-26 2003-03-20 Lynch Mary G. Shunt device and method for treating glaucoma
US6450984B1 (en) 1999-04-26 2002-09-17 Gmp Vision Solutions, Inc. Shunt device and method for treating glaucoma
EP1173124B1 (en) 1999-04-26 2005-04-27 Gmp Vision Solutions, Inc. Shunt device and method for treating glaucoma
US7220238B2 (en) 1999-04-26 2007-05-22 Gmp Vision Solutions, Inc. Shunt device and method for treating glaucoma
EP1173125B1 (en) 1999-04-26 2006-01-25 Gmp Vision Solutions, Inc. Stent device for treating glaucoma
US6783544B2 (en) 1999-04-26 2004-08-31 Gmp Vision Solutions, Inc. Stent device and method for treating glaucoma
US20040260228A1 (en) 1999-04-26 2004-12-23 Lynch Mary G. Stent device and method for treating glaucoma
US6827700B2 (en) 1999-04-26 2004-12-07 Gmp Vision Solutions, Inc. Shunt device and method for treating glaucoma
US6827699B2 (en) 1999-04-26 2004-12-07 Gmp Vision Solutions, Inc. Shunt device and method for treating glaucoma
EP2027837A2 (en) 1999-04-26 2009-02-25 Glaukos Corporation Shunt device and method for treating glaucoma
US6626858B2 (en) 1999-04-26 2003-09-30 Gmp Vision Solutions, Inc. Shunt device and method for treating glaucoma
US6464724B1 (en) 1999-04-26 2002-10-15 Gmp Vision Solutions, Inc. Stent device and method for treating glaucoma
US6699210B2 (en) 1999-04-27 2004-03-02 The Arizona Board Of Regents Glaucoma shunt and a method of making and surgically implanting the same
US6558342B1 (en) 1999-06-02 2003-05-06 Optonol Ltd. Flow control device, introducer and method of implanting
US6726664B2 (en) 1999-06-02 2004-04-27 Optonol Ltd. Flow control device, introducer and method of implanting
US6221078B1 (en) 1999-06-25 2001-04-24 Stephen S. Bylsma Surgical implantation apparatus
US6331313B1 (en) 1999-10-22 2001-12-18 Oculex Pharmaceticals, Inc. Controlled-release biocompatible ocular drug delivery implant devices and methods
US20020072673A1 (en) 1999-12-10 2002-06-13 Yamamoto Ronald K. Treatment of ocular disease
US6969384B2 (en) 2000-01-03 2005-11-29 The Johns Hopkins University Surgical devices and methods of use thereof for enhanced tactile perception
US6676607B2 (en) 2000-01-03 2004-01-13 The Johns Hopkins University Intraoperative microsurgical ultrasonic device and methods related thereto
US20050119737A1 (en) 2000-01-12 2005-06-02 Bene Eric A. Ocular implant and methods for making and using same
US6589203B1 (en) 2000-01-26 2003-07-08 Peter Mitrev Glaucoma drainage device implant
US6471666B1 (en) 2000-02-24 2002-10-29 Steven A. Odrich Injectable glaucoma device
US20020193725A1 (en) 2000-02-24 2002-12-19 Odrich Steven A. Injectable glaucoma device
US20040249333A1 (en) 2000-04-14 2004-12-09 Bergheim Olav B. Glaucoma implant with bi-directional flow
US6955656B2 (en) 2000-04-14 2005-10-18 Glaukos Corporation Apparatus and method for treating glaucoma
US6533768B1 (en) 2000-04-14 2003-03-18 The Regents Of The University Of California Device for glaucoma treatment and methods thereof
US20030060752A1 (en) 2000-04-14 2003-03-27 Olav Bergheim Glaucoma device and methods thereof
US20050209549A1 (en) 2000-04-14 2005-09-22 Bergheim Olav B Glaucoma implant with multiple openings
US20050049578A1 (en) 2000-04-14 2005-03-03 Hosheng Tu Implantable ocular pump to reduce intraocular pressure
US20060195055A1 (en) 2000-04-14 2006-08-31 Bergheim Olav B Shunt device and method for treating glaucoma
US6736791B1 (en) 2000-04-14 2004-05-18 Glaukos Corporation Glaucoma treatment device
US6638239B1 (en) 2000-04-14 2003-10-28 Glaukos Corporation Apparatus and method for treating glaucoma
US20060084907A1 (en) 2000-04-14 2006-04-20 Bergheim Olav B Shunt device and method for treating glaucoma
US20040111050A1 (en) 2000-04-14 2004-06-10 Gregory Smedley Implantable ocular pump to reduce intraocular pressure
US20040127843A1 (en) 2000-04-14 2004-07-01 Hosheng Tu Glaucoma implant with therapeutic agents
US20060074375A1 (en) 2000-04-14 2006-04-06 Bergheim Olav B Shunt device and method for treating glaucoma
US7297130B2 (en) 2000-04-14 2007-11-20 Glaukos Corporation Implant with anchor
US20060195056A1 (en) 2000-04-14 2006-08-31 Bergheim Olav B Shunt device and method for treating glaucoma
US20050277864A1 (en) 2000-04-14 2005-12-15 David Haffner Injectable gel implant for glaucoma treatment
US6780164B2 (en) 2000-04-14 2004-08-24 Glaukos Corporation L-shaped implant with bi-directional flow
US20030187384A1 (en) 2000-04-14 2003-10-02 Bergheim Olav B. Implant with a micropump
US20030187385A1 (en) 2000-04-14 2003-10-02 Bergheim Olav B. Implant with anchor
US20030181848A1 (en) 2000-04-14 2003-09-25 Bergheim Olav B. Implant with drug coating
US20040210185A1 (en) 2000-04-14 2004-10-21 Hosheng Tu Glaucoma implant kit
US20070282244A1 (en) 2000-04-14 2007-12-06 Glaukos Corporation Glaucoma implant with anchor
US20080234624A2 (en) 2000-04-14 2008-09-25 Glaukos Corporation Ocular implant with anchor and therapeutic agent
US20080045878A1 (en) 2000-04-14 2008-02-21 Glaukos Corporation Therapeutic shunt device and method for treating glaucoma
EP1278492B1 (en) 2000-04-14 2009-04-29 Glaukos Corporation Apparatus for treating glaucoma
US20040254519A1 (en) 2000-04-14 2004-12-16 Hosheng Tu Glaucoma treatment device
US20050209550A1 (en) 2000-04-14 2005-09-22 Bergheim Olav B Method of treating glaucoma using an implant having a uniform diameter between the anterior chamber and Schlemm's canal
US20070282245A1 (en) 2000-04-14 2007-12-06 Glaukos Corporation Glaucoma implant with valve
EP1292256A1 (en) 2000-06-19 2003-03-19 Glaukos Corporation Stented trabecular shunt and methods thereof
US6699211B2 (en) 2000-08-22 2004-03-02 James A. Savage Method and apparatus for treatment of glaucoma
EP1184010A2 (en) 2000-08-29 2002-03-06 Aixmed Gesellschaft für Medizintechnik mbH Aqueous humour drainage device
US6719750B2 (en) 2000-08-30 2004-04-13 The Johns Hopkins University Devices for intraocular drug delivery
US6730056B1 (en) 2000-09-21 2004-05-04 Motorola, Inc. Eye implant for treating glaucoma and method for manufacturing same
US6962573B1 (en) 2000-10-18 2005-11-08 Wilcox Michael J C-shaped cross section tubular ophthalmic implant for reduction of intraocular pressure in glaucomatous eyes and method of use
US6544208B2 (en) 2000-12-29 2003-04-08 C. Ross Ethier Implantable shunt device
US6595945B2 (en) 2001-01-09 2003-07-22 J. David Brown Glaucoma treatment device and method
US6881198B2 (en) 2001-01-09 2005-04-19 J. David Brown Glaucoma treatment device and method
US20020111608A1 (en) * 2001-01-18 2002-08-15 George Baerveldt Minimally invasive glaucoma surgical instrument and method
US6989007B2 (en) 2001-02-21 2006-01-24 Solx, Inc. Devices and techniques for treating glaucoma
US20020128613A1 (en) 2001-03-12 2002-09-12 Masanari Nakayama Method of treating eye diseases of animals and artificial lacrimal duct used therefor
US20020133168A1 (en) 2001-03-16 2002-09-19 Smedley Gregory T. Applicator and methods for placing a trabecular shunt for glaucoma treatment
US20020143284A1 (en) 2001-04-03 2002-10-03 Hosheng Tu Drug-releasing trabecular implant for glaucoma treatment
EP1977724A1 (en) 2001-04-07 2008-10-08 Glaukos Corporation System for treating ocular disorders
US20070112292A1 (en) 2001-04-07 2007-05-17 Hosheng Tu Glaucoma stent and methods thereof for glaucoma treatment
US7135009B2 (en) 2001-04-07 2006-11-14 Glaukos Corporation Glaucoma stent and methods thereof for glaucoma treatment
US20040254520A1 (en) 2001-04-07 2004-12-16 Eric Porteous Coil implant for glaucoma treatment
US20090036819A1 (en) 2001-04-07 2009-02-05 Glaukos Corporation Drug eluting ocular implant with anchor and methods thereof
EP1418868B1 (en) 2001-04-07 2008-03-26 Glaukos Corporation Glaucoma stent for glaucoma treatment
US20080200860A1 (en) 2001-04-07 2008-08-21 Glaukos Corporation System for treating ocular disorders and methods thereof
US20040210181A1 (en) 2001-04-26 2004-10-21 Clemens Vass Drainage implant for draining aqueous humour from the anterior aqueous chamber of the eye into schlemm's canal
US20050288619A1 (en) 2001-05-02 2005-12-29 Morteza Gharib Biodegradable glaucoma implant
US6981958B1 (en) 2001-05-02 2006-01-03 Glaukos Corporation Implant with pressure sensor for glaucoma treatment
US6666841B2 (en) 2001-05-02 2003-12-23 Glaukos Corporation Bifurcatable trabecular shunt for glaucoma treatment
US20050192527A1 (en) 2001-05-02 2005-09-01 Morteza Gharib Glaucoma implant with extending members
US20050119636A1 (en) 2001-05-02 2005-06-02 David Haffner Implant with intraocular pressure sensor for glaucoma treatment
US7273475B2 (en) 2001-05-03 2007-09-25 Glaukos Corporation Medical device and methods of use for glaucoma treatment
US20080015488A1 (en) 2001-05-03 2008-01-17 Glaukos Corporation Glaucoma implant with double anchor mechanism
US7094225B2 (en) 2001-05-03 2006-08-22 Glaukos Corporation Medical device and methods of use of glaucoma treatment
US6648283B2 (en) 2001-07-06 2003-11-18 Joanne M. Chase Adjustable ornament display apparatus
US20060241749A1 (en) 2001-08-28 2006-10-26 Hosheng Tu Glaucoma stent system
US20070010827A1 (en) 2001-08-28 2007-01-11 Hosheng Tu Glaucoma stent system
US7331984B2 (en) 2001-08-28 2008-02-19 Glaukos Corporation Glaucoma stent for treating glaucoma and methods of use
US20040050392A1 (en) 2001-08-28 2004-03-18 Hosheng Tu Glaucoma stent for treating glaucoma and methods of use
US20030097151A1 (en) 2001-10-25 2003-05-22 Smedley Gregory T. Apparatus and mitochondrial treatment for glaucoma
US7163543B2 (en) 2001-11-08 2007-01-16 Glaukos Corporation Combined treatment for cataract and glaucoma treatment
EP1310222A3 (en) 2001-11-08 2004-03-17 Glaukos Corporation Drug-releasing trabecular implant for glaucoma treatment
US20030097171A1 (en) 2001-11-20 2003-05-22 Elliott Christopher J. Stent with differential lengthening/shortening members
US6966888B2 (en) 2002-01-13 2005-11-22 Eagle Vision, Inc. Sinus valved glaucoma shunt
US20030135149A1 (en) 2002-01-13 2003-07-17 Cheryl Cullen Sinus valved glaucoma shunt
US6939298B2 (en) 2002-02-28 2005-09-06 Gmp Vision Solutions, Inc Device and method for monitoring aqueous flow within the eye
US20060116626A1 (en) 2002-03-07 2006-06-01 Gregory Smedley Fluid infusion methods for glaucoma treatment
US7186232B1 (en) 2002-03-07 2007-03-06 Glaukoa Corporation Fluid infusion methods for glaucoma treatment
US20060200113A1 (en) 2002-03-07 2006-09-07 David Haffner Liquid jet for glaucoma treatment
US20070118147A1 (en) 2002-03-15 2007-05-24 Smedley Gregory T Combined treatment for cataract and glaucoma treatment
US20030229303A1 (en) 2002-03-22 2003-12-11 Haffner David S. Expandable glaucoma implant and methods of use
US20070276315A1 (en) 2002-04-08 2007-11-29 Glaukos Corporation Devices and methods for glaucoma treatment
US20050271704A1 (en) 2002-04-08 2005-12-08 Hosheng Tu Injectable glaucoma implants with multiple openings
US20050266047A1 (en) 2002-04-08 2005-12-01 Hosheng Tu Injectable glaucoma implants with multiple openings
US20040147870A1 (en) 2002-04-08 2004-07-29 Burns Thomas W. Glaucoma treatment kit
US20070276316A1 (en) 2002-04-08 2007-11-29 Glaukos Corporation Devices and methods for glaucoma treatment
US20040102729A1 (en) 2002-04-08 2004-05-27 David Haffner Devices and methods for glaucoma treatment
US7431710B2 (en) 2002-04-08 2008-10-07 Glaukos Corporation Ocular implants with anchors and methods thereof
US20040024345A1 (en) 2002-04-19 2004-02-05 Morteza Gharib Glaucoma implant with valveless flow bias
US20050273033A1 (en) 2002-05-29 2005-12-08 Grahn Bruce H Shunt and method treatment of glaucoma
US20030236483A1 (en) 2002-06-25 2003-12-25 Ren David H Dual drainage ocular shunt for glaucoma
US7041077B2 (en) 2002-07-19 2006-05-09 Yale University Uveoscleral drainage device
EP1545655B1 (en) 2002-08-08 2008-12-31 Glaukos Corporation Implantable ocular pump to reduce intraocular pressure
US7192412B1 (en) 2002-09-14 2007-03-20 Glaukos Corporation Targeted stent placement and multi-stent therapy
WO2004026347A9 (en) 2002-09-17 2004-07-22 Iscience Surgical Corp Apparatus and method for surgical bypass of aqueous humor
US7090681B2 (en) * 2002-09-18 2006-08-15 Allergan, Inc. Methods and apparatus for delivery of ocular implants
US7488303B1 (en) 2002-09-21 2009-02-10 Glaukos Corporation Ocular implant with anchor and multiple openings
WO2004043231A3 (en) 2002-11-06 2005-07-21 Gmp Vision Solutions Inc Storage apparatus for surgical implant device
WO2004056294A1 (en) 2002-12-19 2004-07-08 Wound Healing Of Oklahoma, Inc Device for ocular aqueous drainage
US7160264B2 (en) 2002-12-19 2007-01-09 Medtronic-Xomed, Inc. Article and method for ocular aqueous drainage
WO2004060219A1 (en) 2002-12-27 2004-07-22 Japan Science And Technology Agency Aqueous humor drainage implant for treating glaucoma
US20060235367A1 (en) 2002-12-27 2006-10-19 Seisuke Takashima Aqueous humor drainage implant for treatment glaucoma
WO2004062469A3 (en) 2003-01-13 2005-05-12 Clarity Corp Sinus valved glaucoma shunt
US20040216749A1 (en) 2003-01-23 2004-11-04 Hosheng Tu Vasomodulation during glaucoma surgery
US20040254517A1 (en) 2003-02-18 2004-12-16 Hugo Quiroz-Mercado Methods and devices for draining fluids and lowering intraocular pressure
US20040193262A1 (en) 2003-03-29 2004-09-30 Shadduck John H. Implants for treating ocular hypertension, methods of use and methods of fabrication
US20040193095A1 (en) 2003-03-29 2004-09-30 Shadduck John H. Implants for treating ocular hypertension, methods of use and methods of fabrication
US20070149915A1 (en) 2003-05-05 2007-06-28 Judith Yablonski Internal shunt and method for treating glaucoma
US20040225250A1 (en) 2003-05-05 2004-11-11 Michael Yablonski Internal shunt and method for treating glaucoma
US20040236343A1 (en) 2003-05-23 2004-11-25 Taylor Jon B. Insertion tool for ocular implant and method for using same
US20060069340A1 (en) 2003-06-16 2006-03-30 Solx, Inc. Shunt for the treatment of glaucoma
WO2004110391A3 (en) 2003-06-16 2006-12-28 Solx Inc Shunt for the treatment of glaucoma
US20040254521A1 (en) 2003-06-16 2004-12-16 Solx, Inc. Shunt for the treatment of glaucoma
US7207965B2 (en) 2003-06-16 2007-04-24 Solx, Inc. Shunt for the treatment of glaucoma
WO2005016418A1 (en) 2003-08-05 2005-02-24 Glaukos Corporation Devices and methods for glaucoma treatment
WO2005016148A1 (en) 2003-08-14 2005-02-24 Andrzej Krysztof Stethoscope with identifying-personalizing ring
US20050143817A1 (en) 2003-11-10 2005-06-30 Angiotech International Ag Medical implants and anti-scarring agents
US20050181977A1 (en) 2003-11-10 2005-08-18 Angiotech International Ag Medical implants and anti-scarring agents
US20050191331A1 (en) 2003-11-10 2005-09-01 Angiotech International Ag Medical implants and anti-scarring agents
WO2005046516A3 (en) 2003-11-10 2006-06-01 Angiotech Int Ag Medical implants and anti-scarring agents
US20050149080A1 (en) 2003-11-10 2005-07-07 Angiotech International Ag Medical implants and anti-scarring agents
US20050175663A1 (en) 2003-11-10 2005-08-11 Angiotech International Ag Medical implants and anti-scarring agents
US20050181011A1 (en) 2003-11-10 2005-08-18 Angiotech International Ag Medical implants and anti-scarring agents
US20070106236A1 (en) 2003-11-14 2007-05-10 Coroneo Minas T Ocular Pressure Regulation
US20050107734A1 (en) 2003-11-14 2005-05-19 Coroneo Minas T. Ocular pressure regulation
US20080195027A1 (en) 2003-11-14 2008-08-14 Minas Theodore Coroneo Ocular pressure regulation
US20070088242A1 (en) 2003-11-14 2007-04-19 Coroneo Minas T Ocular pressure regulation
US20050125003A1 (en) 2003-12-05 2005-06-09 Leonard Pinchuk Glaucoma implant device
WO2005055873A3 (en) 2003-12-05 2007-07-26 Innfocus Llc Improved glaucoma implant device
US20050250788A1 (en) 2004-01-30 2005-11-10 Hosheng Tu Aqueous outflow enhancement with vasodilated aqueous cavity
US20060036207A1 (en) 2004-02-24 2006-02-16 Koonmen James P System and method for treating glaucoma
US20050197613A1 (en) 2004-03-02 2005-09-08 Sniegowski Jeffry J. Implant having MEMS flow module with movable, flow-controlling baffle
US20050232972A1 (en) 2004-04-15 2005-10-20 Steven Odrich Drug delivery via punctal plug
WO2005107664A3 (en) 2004-04-29 2005-12-22 Iscience Surgical Corp Apparatus and method for surgical enhancement of aqueous humor drainage
WO2005107845A1 (en) 2004-04-29 2005-11-17 Iscience Interventional Corporation Apparatus and method for ocular treatment
US20050244462A1 (en) 2004-04-30 2005-11-03 Allergan, Inc. Devices and methods for treating a mammalian eye
US20050267397A1 (en) 2004-05-20 2005-12-01 Ajay Bhalla Aqueous drainage and flow regulating implant
US20050267398A1 (en) 2004-05-27 2005-12-01 Dimitri Protopsaltis Glaucoma shunt
US20050283108A1 (en) 2004-06-10 2005-12-22 Savage James A Apparatus and method for non-pharmacological treatment of glaucoma and lowering intraocular pressure
US20050288617A1 (en) 2004-06-25 2005-12-29 Ira Yaron Flow regulating implants
WO2006012421A2 (en) 2004-07-20 2006-02-02 St. Jude Medical, Atrial Fibrillation Division, Inc. Steerable catheter with hydraulic or pneumatic actuator
US20060020248A1 (en) 2004-07-26 2006-01-26 Prescott Anthony D Lacrimal insert having reservoir with controlled release of medication and method of manufacturing the same
US20060032507A1 (en) 2004-08-11 2006-02-16 Hosheng Tu Contrast-enhanced ocular imaging
WO2006036715A3 (en) 2004-09-24 2007-06-07 Glaukos Corp Implant and pressure sensor for glaucoma treatment
US20060173397A1 (en) 2004-11-23 2006-08-03 Hosheng Tu Ophthalmology implants and methods of manufacture
US20070191863A1 (en) 2006-01-17 2007-08-16 De Juan Eugene Jr Glaucoma Treatment Device
WO2007087061A3 (en) 2006-01-17 2007-12-13 Transcend Medical Inc Glaucoma treatment device
WO2007115259A2 (en) 2006-03-31 2007-10-11 Qlt Plug Delivery, Inc. Nasolacrimal drainage system implants for drug therapy
US20070293807A1 (en) 2006-05-01 2007-12-20 Lynch Mary G Dual drainage pathway shunt device and method for treating glaucoma
WO2008061043A2 (en) 2006-11-10 2008-05-22 Glaukos Corporation Uveoscleral shunt and methods for implanting same
US20080228127A1 (en) 2006-11-10 2008-09-18 Glaukos Corporation Uveoscleral shunt and methods for implanting same

Non-Patent Citations (37)

* Cited by examiner, † Cited by third party
Title
"The Solx Gold Micro-shunt (GMS) Treatment," Solx clinical literature hand-out from Industry Show, Feb. 2006.
Bick, M., "Use of Tantalum for Ocular Drainage," Arch Ophthal. Oct. 1949; 42(4): 373-88.
Bietti, "The present state of the use of plastics in eye surgery" Acta Ophthalmol (Copenh) 1955; 33(4):337-70.
Classen, L., et al., "A histopathologic and immunohistorchemical analysis of the filtration bleb after unsuccessful glaucoma seton implantation," American Journal of Opthamology, 122:205-212, (1996).
Cohen, V.M., et al., "First day post-operative review following uncomplicated phacoemulsification," Eye, 12(4):634-636, (1998).
Derwent English abstract for EP 1184010, published Mar. 6, 2002 entitled: "Drainage unit for an eye, consists of a hollow line, a distribution member, and a pressure relief valve which only allows water to leave the eye chamber above a certain pressure," Accession Nbr. 12409716 [351].
Dinakaran, S., et al., "Is the first post-operative day review necessary following uncomplicated phacoemulsification surgery?" Eye, 14(3A)364-366, (2000).
Einmahl, S., et al., "Evaluation of a novel biomaterial in the suprachoroidal space of the rabbit eye," Investigative Opthamology and Visual Sciences, 43:1533-1539, (2002).
Emi et al. "Hydrostatic pressure of the suprachoroidal space" Invest. Ophthal. Visual Sci. 30(2):233-238 (1989).
Fuchs E. "Detachment of the choroid inadvertently during cataract surgery," von Graefes Arch Ophthalmol, 51:199-224 (1900) [German with English Languauge abstract].
Gills et al., "Action of cyclodialysis utilizing an implant studied by manometry in a human eye" Exp Eye Res 1967; 6:75-78.
Gills, "Cyclodialysis implants" South Med J. 1967 60(7):692-5.
Gross, R.L., et al., "Surgical therapy of chronic glaucoma in aphakia and pseudophakia," Ophthalmology, 95:1195-1201, (1988).
Heine I. "Cyclodialysis, a new glaucoma operation," Dtsch Med Wochenschr, 31:824-826 (1905) [German with English Languauge abstract].
Hildebrand, G.D., et al., "Efficacy of anterior chamber decompression in controlling early intraocular pressure spikes after uneventful phacoemulsification," Journal of Cataract and Refractive Surgery, 29:1087-1092, (2003).
Howorth, D.J., "Feasibility study for a micromachined glaucoma drainage device," Cranfield University School of industrial and manufacturing science MSc Thesis Academic Year 2001-2002 Sep. 13, 2002.
Hylton, C. and A. Robin et al., "Update on prostaglandin analogs," Current Opinion in Opthamology, 14:65-69, (2003).
Jordan et al., "A Novel Approach to Suprachoroidal Drainage for the Surgical Treatment of Intractable Glaucoma," J. Glaucoma 2006; 15:200-205.
Jordan, J. "A novel approach to suprachoroidal drainage for the surgical treatment of intractable glaucoma," Journal of Glaucoma, 15:200-205, (2006).
Karlen et al., "Deep sclerectomy with collagen implant:medium term results" Br. J. Ophthalmol, 83(1):6-11 (1999).
Klemm et al., "Experimental use of space-retaining substances with extended duration: functional and morphological results" Graefes Arch Clin Exp Ophthalmol Sep. 1995; 233(9):592-7.
Kozlov et al. "Nonpenetrating deep sclerectomy with collagen," Eye Microsurgery 3:44-46 (1990). [Russian with English translation].
Krejci, "Cyclodialysis with hydroxymethyl methacrylate capillary strip (HCS). Animal experiments with a new approach in glaucoma drainage surgery" Ophthalmologica 1972; 164(2):113-21.
Krejċi, "Cyclodialysis with hydroxymethyl methacrylate capillary strip (HCS). Animal experiments with a new approach in glaucoma drainage surgery" Ophthalmologica 1972; 164(2):113-21.
Lee et al. "Magnetic resonance imaging of the aqueous flow in eyes implanted with the trabeculosuprachoroidal glaucoma seton," Investigative Opthamology and Visual Sciences 33:948 (1992).
Losche, "Proposals for improvement of cyclodialysis" Klin Monatsblatter Augenheilkd Augenarztl Fortbild 1952, 121(6):715-6 [Article in German; English language translation provided].
Mehta, K.R., "The suprachoroidal hema wedge in glaucoma surgery," American Academy of Ophthalmology meeting 1977 pp. 144.
Nesterov AP et al., "Surgical stimulation of the uveoscleral outflow. Experimental studies on enucleated human eyes" Acta Opthalmol (Copenh) Jun.; 57(3):409-17 (1979).
Ozdamar et al., "Suprachoroidal seton implantation in refractory glaucoma: a novel surgical technique" J. Glaucoma Aug. 2003; 12(4):354-9.
Pinnas et al., "Cyclodialysis with teflon tube implants" Am J. Ophthalmol 1969 Nove; 68(5):879-883.
Rosenberg, L. and T. Krupin, The Glaucomas, Second Edition, Chapter 88, Eds., Ritch, R., et al., Mosby, St. Louis, MO., pp. 1783-1807, (1986).
Row H., "Operation to Control Glaucoma," (1934) Arch. Ophthal 12, 325.
Srinivasan, R. et al., "Microbial contamination of the anterior chamber during phacoemulsification," Journal of Cataract and Refractive Surgery, 28:2173-2176, (2002).
Toris, C., et al., "Aqueous humor dynamics in the aging human eye," American Journal of Opthamology, 127:407-412, (1999).
Troncosco UM, Cyclodialysis with insertion of metal implant in treatment of glaucoma Preliminary report Arch. Ophth. 23:270, 1940.
Yablonski, M.E., "Some thoughts on the pressure dependence of uveoscleral flow," Journal of Glaucoma, 12(1):90-92, (2003).
Yablonski, M.E., "Trabeculectomy with Internal Tube Shunt: a novel glaucoma surgery," Journal of Glaucoma, 14:91-97, (2005).

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US8007459B2 (en) 2002-09-21 2011-08-30 Glaukos Corporation Ocular implant with anchoring mechanism and multiple outlets
US20160346125A1 (en) * 2003-11-14 2016-12-01 Transcend Medical, Inc. Ocular Pressure Regulation
US10226380B2 (en) * 2003-11-14 2019-03-12 Novartis Ag Ocular pressure regulation
US10905590B2 (en) 2006-01-17 2021-02-02 Alcon Inc. Glaucoma treatment device
US11786402B2 (en) 2006-01-17 2023-10-17 Alcon Inc. Glaucoma treatment device
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US10960074B2 (en) 2009-02-25 2021-03-30 John Berdahl Process for treating glaucoma
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US9168172B1 (en) * 2009-02-25 2015-10-27 Dr. John Berdahl Process for treating glaucoma
US10842671B2 (en) 2010-11-15 2020-11-24 Aquesys, Inc. Intraocular shunt placement in the suprachoroidal space
US10307293B2 (en) 2010-11-15 2019-06-04 Aquesys, Inc. Methods for intraocular shunt placement
US10004638B2 (en) 2010-11-15 2018-06-26 Aquesys, Inc. Intraocular shunt delivery
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US10080682B2 (en) 2011-12-08 2018-09-25 Aquesys, Inc. Intrascleral shunt placement
US9883969B2 (en) 2011-12-08 2018-02-06 Aquesys, Inc. Intrascleral shunt placement
US10940041B1 (en) 2012-03-09 2021-03-09 John Berdahl Eye cavity pressure treatment using IOP or CSF
US10195078B2 (en) 2013-02-19 2019-02-05 Aquesys, Inc. Adjustable intraocular flow regulation
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US11612517B2 (en) 2015-06-03 2023-03-28 Aquesys, Inc. Ab externo intraocular shunt placement
US10470927B2 (en) 2015-06-03 2019-11-12 Aquesys, Inc. AB externo intraocular shunt placement
US10463537B2 (en) 2015-06-03 2019-11-05 Aquesys Inc. Ab externo intraocular shunt placement
US11246753B2 (en) 2017-11-08 2022-02-15 Aquesys, Inc. Manually adjustable intraocular flow regulation
US11786122B2 (en) 2018-08-09 2023-10-17 Equinox Ophthalmic, Inc. Apparatus and methods to adjust ocular blood flow
US11045355B2 (en) 2019-06-14 2021-06-29 Iantrek, Inc. Implantable biologic stent and system for biologic material shaping, preparation, and intraocular stenting for increased aqueous outflow and lowering of intraocular pressure
US11925580B2 (en) 2019-06-14 2024-03-12 Iantrek, Inc. Implantable biologic stent and system for biologic material shaping and preparation in the treatment of glaucoma

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US20110087150A1 (en) 2011-04-14
US20110087151A1 (en) 2011-04-14
US20050107734A1 (en) 2005-05-19
US20110028884A1 (en) 2011-02-03
US20140188030A1 (en) 2014-07-03
US8758289B2 (en) 2014-06-24
US7815592B2 (en) 2010-10-19
AU2004288609B2 (en) 2010-10-28
AU2004288609A1 (en) 2005-05-26
US9351873B2 (en) 2016-05-31
US20160346125A1 (en) 2016-12-01
US8728021B2 (en) 2014-05-20
US8771218B2 (en) 2014-07-08
US20080195027A1 (en) 2008-08-14
US8128588B2 (en) 2012-03-06
US8486000B2 (en) 2013-07-16
US10226380B2 (en) 2019-03-12
US20070088242A1 (en) 2007-04-19
US8808220B2 (en) 2014-08-19
WO2005046782A1 (en) 2005-05-26
US20070106235A1 (en) 2007-05-10
EP1732634A4 (en) 2010-06-09
US20070106236A1 (en) 2007-05-10
US7291125B2 (en) 2007-11-06
US20110087149A1 (en) 2011-04-14

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