US3688764A - Intracutaneous injection system - Google Patents
Intracutaneous injection system Download PDFInfo
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- US3688764A US3688764A US65424A US3688764DA US3688764A US 3688764 A US3688764 A US 3688764A US 65424 A US65424 A US 65424A US 3688764D A US3688764D A US 3688764DA US 3688764 A US3688764 A US 3688764A
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- well
- applicator
- puncture
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/20—Surgical instruments, devices or methods, e.g. tourniquets for vaccinating or cleaning the skin previous to the vaccination
- A61B17/205—Vaccinating by means of needles or other puncturing devices
Definitions
- ABSTRACT The present invention is directed to an intradermal injection system adapted for multiple mass use, particularly for mass diagnostic testing such as the Heat Multiple Puncture Tuberculic Test.
- the structure includes an elongated finger grip skin puncture applicator with a set of puncture points mounted in the base face of the applicator.
- a solution holder having therein an antigen well of pre-determined capacity.
- An escape channel leading to an overflow well removes any excess antigen from the well.
- a centering and stop element which cooperates with a correspondingly shaped depression inside the base of the applicator so that the applicator may be centered in the antigen well with all of the applicator puncture points wetted by the antigen solution therein to a pre-determined level.
- the present invention relates to an intracutaneous injection system comprising a skin puncture applicator and a solution holder and is explicitly intended for mass testing or treatment of an intracutaneous nature.
- the present system is adapted to mass conduct of the multiple puncture tuberculin test known as the Heaf Test, and will be described for exemplary purposes in terms of this particular usage.
- a principal problem in mass testing e. g. for tuberculosis, resides in the need for sterile equipment of an inexpensive nature. Desirably, the equipment must be utilizable (safely) by technicians or semi-skilled personnel.
- An important criterion, one which applies to individual tests as well as mass tests, is that the proper amount of medicament must be applied. In mass screening this requirement is translated into the usual statement that uniform dosages must be employed.
- the present invention allows for bulk packaging of the medicament and relies on the structure of the skin puncture applicator and an associated antigen solution holder to insure that each test is conducted with the same medicament dosage.
- FIG. 1 is a side view of the medicament applicator and a protective cap therefor;
- FIG. 2 is a section taken along line 2-2 of FIG. 1 showing the applicator and cap assembled
- FIG. 3 is a perspective view of the applicator
- FIG. 4 is an elevational view of the skin puncture end of the applicator
- FIG. 5 is a perspective view of the applicator and the solution holder.
- FIG. 6 is a partially broken away section taken along line 6-6 ofFIG. 5.
- the intracutaneous or intradermal injection system of the present invention comprises a skin puncture applicator l0 and a solution holder 12.
- a protective cap 14 is provided for sterile storage and shipment of the applicator.
- the applicator itself comprises a finger grip handle 16, preferably of the bi-concave shape shown in FIGS. 3 and 5.
- the bi-concave shape permits a good finger grip.
- an annular circular flange 18 which seats over the top edge of cylindrical body 22 of the protective cap 14 so that for sterile shipment and storage the puncture points on the base face of applicator 10 are suspended above the bottom wall 24 of the cap 14, as is illustrated in FIG. 2.
- Flange 18 also serves as a shield preventing contact between the holders fingers and the medicament.
- Beneath flange 18 and forming part of the applicator 10 is a cylindrical body portion 26 and the skin puncture points 20 are mounted on the base face at the bottom thereof.
- the puncture points 20, six annularly positioned points being illustrated form part of a metallic insert piece 28 set into the base face of body portion 26.
- insert piece 28 is formed from sheet stock, e.g. stainless steel, by stamping out the desired peripheral point configuration, then upending the puncture points perpendicular to the remainder of the insert piece 28.
- the central aperture 32 in insert piece 28 may be stamped out when the points are formed. Insert piece 28 is retained at the base end of applicator 10 by a friction grip or by an overhand engagement with lip-like projections 30 formed on the base face of applicator 10.
- central cone or frustro-conic depression 34 centrally of the base face.
- central opening 32 in insert piece 28 underlies depression 34 and the individual puncture points 20 are symmetrically disposed therearound, so that a projection corresponding in shape to central depression 34 can be employed as a centering expedient.
- the skin puncture applicator 10 can be employed, as is, for single tests according to the usual techniques for such tests.
- the antigen may be placed directly on a small (about 1 inch square) clean skin region and the puncture point applicator pushed in at that region so that the six puncture points penetrate the upper layers of the skin and force antigen from the surface intracutaneously.
- the applicator which is relatively inexpensive, may be considered as a disposable unit and discarded.
- the same applicator structure is equally adapted for mass testing wherein it is employed in combination with medicament or antigen holder 12.
- solution holder 12 has the general shape of an inverted cup wherein a cylindrical skirt 38 supports an upper depressed surface area 40 which contains thereon an antigen well 42, an overflow well 44, and a connecting escape channel 46. Should excess antigen be placed in well 42, the excess will overflow through escape channel 46 into overflow well 44, from which, at some convenient time, it may be recovered (by a sterile eyedropper), and recovered or returned to antigen well 42.
- Upstanding from the center of antigen well 42 is a frustro-conic projection 48 corresponding in shape and dimensions to central depression 34 in the base face of applicator 10. Projection 48 and aperture 34 cooperate so that when the ap plicator 10 is inserted into antigen well 42 the applicator is centered and all the puncture points 20 are wet with the antigen therein, without coming into contact with the well walls.
- the projection 48 on solution holder 12 and central depression 34 on the applicator l0 constitutes also a stop structure which prevents the user from inserting applicator 10 too deeply into well 42.
- a ridge 50 formed peripherally around projection 48 at an appropriate level thereon acts as a visual filling indicator and can also form a portion of the stop structure.
- the puncture points 20 are spaced apart from the well side and bottom walls as is shown in the drawing and are neither bent nor blunted by contact with the well walls. This maintains the desired degree of test uniformity in a mass testing program.
- the flat top of projection 48 can serve as the stop element by abutting the flat end of depression 34, ridge 50 then serving a visual indicator purpose only.
- tuberculin antigen may be procured in bulk solution and the test program commenced by placing whatever number of drops, three, four, five that are required to fill well 42 to the level indicated by the ridge 50. Any accidental overfilling will drain through escape channel 46 into overflow well 44 (from which the antigen may be retrieved). After every five or six tests, an additional drop of tuberculin antigen solution is added to well 42 to maintain the desired level of solution in the well. Accordingly, each successive test is carried out with the proper quantity of solution on the puncture points 20 of applicator 10. Any solution which wets the surface of insert piece 28 has no effect on the test and, constitutes a small wastage.
- the solution holder 12 When the test series is completed, the solution holder 12 may be discarded (along with the test antigen remaining in well 42), the solution holder 12 is a relatively inexpensive, one-time use, disposable article. However, it may be noted that the same solution holder 12 is employed for a series of tests, e.g. l day's use. However, disposition of applicator after each individual test might be unreasonably wasteful. Accordingly, for use of the present system for mass testing purposes, applicator 10 may, if desired, be meticulously cleaned and sterilized and reused, the applicator being, however, ultimately discarded as a disposable item.
- the thermoplastic resins such as polyvinylchloride, polystyrene, polyethylene, polypropylene, etc., all of which can be readily molded into the desired shaped with conventional techniques and equipment.
- the thermoplastic resins exhibit sufficient structural stability so that the well 42 and escape channel 46 may be formed with volumetric accuracy and projection 48 and its ridge 50 can be accurate enough to mate with central-depression 34 and central aperture 32 of applicator 10.
- the standard thermoplastic resin moldings can include a lip 30 for the friction or overlap fit which retains the metallic insert piece 28 on the base face of applicator 10.
- An intracutaneous applicator system comprising an intradermal applicator member removably received in a solution supply holder, said member and holder cooperating to apply solution to said applicator for intradermal njections sai appjicator having a bas c inection su ace, a p many 0 puncture or scan ymg means located on said surface and projecting therefrom, a centrally located depression in said surface, a first well in said holder, an upstanding projection in said first well of a predetermined shape and extending into said depression to center the applicator member in relation to said first well and limiting the depth of penetration of said base surface and puncture means into said first well, an overflow well located in said holder, an escape channel means in the top of said holder and communicating with both said wells whereby excess solution placed in said first well will pass to said overflow well to limit the amount of solution in said first well to a predetermined level, said level being related to the limited depth of penetration of said applicator by said upstanding projection so
- said upstanding projection has a peripheral ridge thereon, the shape of said projection and depression being such that said ridge is sized to contact the area of said base surface to limit the depth of penetration of said applicator into said first well, said ridge also acting as a visual indicator for determining when said first well has a predetermined amount of solution therein.
Abstract
The present invention is directed to an intradermal injection system adapted for multiple mass use, particularly for mass diagnostic testing such as the Heaf Multiple Puncture Tuberculic Test. The structure includes an elongated finger grip skin puncture applicator with a set of puncture points mounted in the base face of the applicator. Associated with the applicator is a solution holder having therein an antigen well of pre-determined capacity. An escape channel leading to an overflow well removes any excess antigen from the well. Upstanding from the center of the antigen well is a centering and stop element which cooperates with a correspondingly shaped depression inside the base of the applicator so that the applicator may be centered in the antigen well with all of the applicator puncture points wetted by the antigen solution therein to a pre-determined level.
Description
[ 1 Sept. 5, 1972 [541 INTRACUTANEOUS INJECTION SYSTEM [72] Inventor: Jack Owen Reed, Englewood, NJ.
[73] Assignee: Bard-Hamilton Company, Inc.,
West Englewood, NJ.
[22] Filed: Aug. 20, 1970 [21] Appl. No.: 65,424
[52] US. Cl. ..128/2 R, 128/2 W, 128/213,
128/253, 128/333, 206/63.4 [51] Int. Cl. ..A6lb 10/00 [58] Field of Search ..128/2 W, 2 G, 2 R, 213, 253,
[56] References Cited UNITED STATES PATENTS 3,596,660 8/1971 Melone ..128/253 2,522,309 9/ 1950 Simon ..128/253 X 3,322,121 5/1967 Banker 128/253 3,246,647 4/ 1966 Taylor et al. ..128/253 3,510,933 5/1970 Taylor et a1 ..128/253 X 3,556,080 l/1971 l-lein ..128/2 W 3,470,01 1 9/1969 Szumski et al. ..128/253 X 3,465,717 9/1969 Hein ..128/253 X 3,291,129 12/1966 Burelle et al. ..128/253 FOREIGN PATENTS OR APPLICATIONS 1,309,352 10/1962 France ..128/253 1,461,996 11/1966 France... ..128/253 232,454 9/1969 U.S.S.R. ..128/253 Primary Examiner-Kyle L; Howell Attorney-Fidelman, Wolfie & Leitner [57] ABSTRACT The present invention is directed to an intradermal injection system adapted for multiple mass use, particularly for mass diagnostic testing such as the Heat Multiple Puncture Tuberculic Test.
The structure includes an elongated finger grip skin puncture applicator with a set of puncture points mounted in the base face of the applicator. Associated with the applicator is a solution holder having therein an antigen well of pre-determined capacity. An escape channel leading to an overflow well removes any excess antigen from the well. Upstanding from the center of the antigen well is a centering and stop element which cooperates with a correspondingly shaped depression inside the base of the applicator so that the applicator may be centered in the antigen well with all of the applicator puncture points wetted by the antigen solution therein to a pre-determined level.
4Claims,6DrawingFigures INTRACUTANEOUS INJECTION SYSTEM The present invention relates to an intracutaneous injection system comprising a skin puncture applicator and a solution holder and is explicitly intended for mass testing or treatment of an intracutaneous nature. In particular, the present system is adapted to mass conduct of the multiple puncture tuberculin test known as the Heaf Test, and will be described for exemplary purposes in terms of this particular usage.
A principal problem in mass testing, e. g. for tuberculosis, resides in the need for sterile equipment of an inexpensive nature. Desirably, the equipment must be utilizable (safely) by technicians or semi-skilled personnel. An important criterion, one which applies to individual tests as well as mass tests, is that the proper amount of medicament must be applied. In mass screening this requirement is translated into the usual statement that uniform dosages must be employed.
An obvious way to insure uniform dosages is to package the medicament in dosage units. However, for mass testing, such an expedient sharply raises the medicament cost of the test program. The present invention allows for bulk packaging of the medicament and relies on the structure of the skin puncture applicator and an associated antigen solution holder to insure that each test is conducted with the same medicament dosage.
For further understanding of the invention, reference is now made to the attached drawing wherein:
FIG. 1 is a side view of the medicament applicator and a protective cap therefor;
FIG. 2 is a section taken along line 2-2 of FIG. 1 showing the applicator and cap assembled;
FIG. 3 is a perspective view of the applicator;
FIG. 4 is an elevational view of the skin puncture end of the applicator;
FIG. 5 is a perspective view of the applicator and the solution holder; and
FIG. 6 is a partially broken away section taken along line 6-6 ofFIG. 5.
The intracutaneous or intradermal injection system of the present invention comprises a skin puncture applicator l0 and a solution holder 12. For sterile storage and shipment of the applicator, a protective cap 14 is provided.
The applicator itself comprises a finger grip handle 16, preferably of the bi-concave shape shown in FIGS. 3 and 5. The bi-concave shape permits a good finger grip. Near the base end of applicator is an annular circular flange 18 which seats over the top edge of cylindrical body 22 of the protective cap 14 so that for sterile shipment and storage the puncture points on the base face of applicator 10 are suspended above the bottom wall 24 of the cap 14, as is illustrated in FIG. 2. Flange 18 also serves as a shield preventing contact between the holders fingers and the medicament.
Beneath flange 18 and forming part of the applicator 10 is a cylindrical body portion 26 and the skin puncture points 20 are mounted on the base face at the bottom thereof. The puncture points 20, six annularly positioned points being illustrated (the usual number for the Heaf test), form part of a metallic insert piece 28 set into the base face of body portion 26. Suitably, insert piece 28 is formed from sheet stock, e.g. stainless steel, by stamping out the desired peripheral point configuration, then upending the puncture points perpendicular to the remainder of the insert piece 28. The central aperture 32 in insert piece 28 may be stamped out when the points are formed. Insert piece 28 is retained at the base end of applicator 10 by a friction grip or by an overhand engagement with lip-like projections 30 formed on the base face of applicator 10.
An important structural feature of application 10 is the central cone or frustro-conic depression 34 centrally of the base face. As is shown in FIG. 4, central opening 32 in insert piece 28 underlies depression 34 and the individual puncture points 20 are symmetrically disposed therearound, so that a projection corresponding in shape to central depression 34 can be employed as a centering expedient.
The skin puncture applicator 10 can be employed, as is, for single tests according to the usual techniques for such tests. For example, the antigen may be placed directly on a small (about 1 inch square) clean skin region and the puncture point applicator pushed in at that region so that the six puncture points penetrate the upper layers of the skin and force antigen from the surface intracutaneously. The applicator, which is relatively inexpensive, may be considered as a disposable unit and discarded. The same applicator structure, however, is equally adapted for mass testing wherein it is employed in combination with medicament or antigen holder 12.
As is shown in FIGS. 5 and 6, solution holder 12 has the general shape of an inverted cup wherein a cylindrical skirt 38 supports an upper depressed surface area 40 which contains thereon an antigen well 42, an overflow well 44, and a connecting escape channel 46. Should excess antigen be placed in well 42, the excess will overflow through escape channel 46 into overflow well 44, from which, at some convenient time, it may be recovered (by a sterile eyedropper), and recovered or returned to antigen well 42. Upstanding from the center of antigen well 42 is a frustro-conic projection 48 corresponding in shape and dimensions to central depression 34 in the base face of applicator 10. Projection 48 and aperture 34 cooperate so that when the ap plicator 10 is inserted into antigen well 42 the applicator is centered and all the puncture points 20 are wet with the antigen therein, without coming into contact with the well walls.
The projection 48 on solution holder 12 and central depression 34 on the applicator l0 constitutes also a stop structure which prevents the user from inserting applicator 10 too deeply into well 42. Desirably, a ridge 50 formed peripherally around projection 48 at an appropriate level thereon acts as a visual filling indicator and can also form a portion of the stop structure. Thus, when the applicator 10 is fully inserted into solution well 42, as is illustrated in FIG. 6, the inside rim of the metallic insert 28 (surrounding its central aperture 32) comes into abutting contact with ridge 50; the entire area of each puncture point 20 is then wetted by the solution in well 42. Any excess solution, in well 42, is forced into escape channel 46 and overflows into overflow well 44. At this time the puncture points 20 are spaced apart from the well side and bottom walls as is shown in the drawing and are neither bent nor blunted by contact with the well walls. This maintains the desired degree of test uniformity in a mass testing program. Alternatively, the flat top of projection 48 can serve as the stop element by abutting the flat end of depression 34, ridge 50 then serving a visual indicator purpose only.
For mass testing with the system of the present invention the tuberculin antigen may be procured in bulk solution and the test program commenced by placing whatever number of drops, three, four, five that are required to fill well 42 to the level indicated by the ridge 50. Any accidental overfilling will drain through escape channel 46 into overflow well 44 (from which the antigen may be retrieved). After every five or six tests, an additional drop of tuberculin antigen solution is added to well 42 to maintain the desired level of solution in the well. Accordingly, each successive test is carried out with the proper quantity of solution on the puncture points 20 of applicator 10. Any solution which wets the surface of insert piece 28 has no effect on the test and, constitutes a small wastage. When the test series is completed, the solution holder 12 may be discarded (along with the test antigen remaining in well 42), the solution holder 12 is a relatively inexpensive, one-time use, disposable article. However, it may be noted that the same solution holder 12 is employed for a series of tests, e.g. l day's use. However, disposition of applicator after each individual test might be unreasonably wasteful. Accordingly, for use of the present system for mass testing purposes, applicator 10 may, if desired, be meticulously cleaned and sterilized and reused, the applicator being, however, ultimately discarded as a disposable item.
Regardless of whether the. intent is to employ applicator 10 on a strictly one-time basis or for a reasonable number of tests, many standard materials are available from which applicator and holder may be formed, notably, the thermoplastic resins such as polyvinylchloride, polystyrene, polyethylene, polypropylene, etc., all of which can be readily molded into the desired shaped with conventional techniques and equipment. The thermoplastic resins exhibit sufficient structural stability so that the well 42 and escape channel 46 may be formed with volumetric accuracy and projection 48 and its ridge 50 can be accurate enough to mate with central-depression 34 and central aperture 32 of applicator 10. In addition, the standard thermoplastic resin moldings can include a lip 30 for the friction or overlap fit which retains the metallic insert piece 28 on the base face of applicator 10.
Although the structure of the present invention has been described in terms of the Heaf Multiple Puncture Tuberculin Test, it should be appreciated that the same or essentially the same structure is equally applicable to other intracutaneous injections of a mass nature, in-
cluding both diagnostics and immunizations such as vaccinations. The only expressly contemplated change in the system for other uses is substitution of the six pointed insert piece 28 by a like insert piece having whatever skin puncture or scarifying points are preferred for the particular usage.
What is claimed is:
1. An intracutaneous applicator system comprising an intradermal applicator member removably received in a solution supply holder, said member and holder cooperating to apply solution to said applicator for intradermal njections sai appjicator having a bas c inection su ace, a p many 0 puncture or scan ymg means located on said surface and projecting therefrom, a centrally located depression in said surface, a first well in said holder, an upstanding projection in said first well of a predetermined shape and extending into said depression to center the applicator member in relation to said first well and limiting the depth of penetration of said base surface and puncture means into said first well, an overflow well located in said holder, an escape channel means in the top of said holder and communicating with both said wells whereby excess solution placed in said first well will pass to said overflow well to limit the amount of solution in said first well to a predetermined level, said level being related to the limited depth of penetration of said applicator by said upstanding projection so that only said puncture means are coated with said solution and not said base surface thus facilitating that an accurately determined amount of solution will be on said applicator when used on a patient.
2. A system as in claim 1 wherein said upstanding projection has a peripheral ridge thereon, the shape of said projection and depression being such that said ridge is sized to contact the area of said base surface to limit the depth of penetration of said applicator into said first well, said ridge also acting as a visual indicator for determining when said first well has a predetermined amount of solution therein.
3. A system as in claim 1 wherein the top of said holder is generally depressed, said first well and upstanding projection being located in the center of said depressed top and said overflow well being located adjacent said first well.
4. A system as in claim 1 wherein said upstanding projection and said depression are both frustro-conical in shape and said puncture or scarifying means are integral with an insert piece located on said base surface, said insert piece having a central aperture overlying the opening of said depression, said puncture or scarifying means being equally spaced from said depression.
t a: a:
Claims (4)
1. An intracutaneous applicator system comprising an intradermal applicator member removably received in a solution supply holder, said member and holder cooperating to apply solution to said applicator for intradermal injections, said applicator having a base injection surface, a plurality of puncture or scarifying means located on said surface and projecting therefrom, a centrally located depression in said surfacE, a first well in said holder, an upstanding projection in said first well of a predetermined shape and extending into said depression to center the applicator member in relation to said first well and limiting the depth of penetration of said base surface and puncture means into said first well, an overflow well located in said holder, an escape channel means in the top of said holder and communicating with both said wells whereby excess solution placed in said first well will pass to said overflow well to limit the amount of solution in said first well to a predetermined level, said level being related to the limited depth of penetration of said applicator by said upstanding projection so that only said puncture means are coated with said solution and not said base surface thus facilitating that an accurately determined amount of solution will be on said applicator when used on a patient.
2. A system as in claim 1 wherein said upstanding projection has a peripheral ridge thereon, the shape of said projection and depression being such that said ridge is sized to contact the area of said base surface to limit the depth of penetration of said applicator into said first well, said ridge also acting as a visual indicator for determining when said first well has a predetermined amount of solution therein.
3. A system as in claim 1 wherein the top of said holder is generally depressed, said first well and upstanding projection being located in the center of said depressed top and said overflow well being located adjacent said first well.
4. A system as in claim 1 wherein said upstanding projection and said depression are both frustro-conical in shape and said puncture or scarifying means are integral with an insert piece located on said base surface, said insert piece having a central aperture overlying the opening of said depression, said puncture or scarifying means being equally spaced from said depression.
Applications Claiming Priority (1)
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US6542470A | 1970-08-20 | 1970-08-20 |
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US65424A Expired - Lifetime US3688764A (en) | 1970-08-20 | 1970-08-20 | Intracutaneous injection system |
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US4222392A (en) * | 1979-05-23 | 1980-09-16 | Alier-Screen, Inc. | Allergy testing device with vented base |
US4270548A (en) * | 1979-09-05 | 1981-06-02 | Aller-Screen, Inc. | Allergy testing method |
US4304241A (en) * | 1978-09-05 | 1981-12-08 | Aller-Screen, Inc. | Skin testing device |
EP0053206A1 (en) * | 1980-11-27 | 1982-06-09 | Isadore Pitesky | Injection assembly |
US4796624A (en) * | 1986-11-19 | 1989-01-10 | Concept, Inc. | Lashliner |
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US9125718B2 (en) | 2010-04-30 | 2015-09-08 | Apollo Endosurgery, Inc. | Electronically enhanced access port for a fluid filled implant |
US9174035B2 (en) | 2004-11-18 | 2015-11-03 | 3M Innovative Properties Company | Microneedle array applicator and retainer |
US9192501B2 (en) | 2010-04-30 | 2015-11-24 | Apollo Endosurgery, Inc. | Remotely powered remotely adjustable gastric band system |
US9199069B2 (en) | 2011-10-20 | 2015-12-01 | Apollo Endosurgery, Inc. | Implantable injection port |
US9682198B2 (en) | 2003-08-28 | 2017-06-20 | Becton, Dickinson And Company | Intradermal injection device |
US10035008B2 (en) | 2005-04-07 | 2018-07-31 | 3M Innovative Properties Company | System and method for tool feedback sensing |
US10987468B2 (en) | 2016-01-05 | 2021-04-27 | Bigfoot Biomedical, Inc. | Operating multi-modal medicine delivery systems |
US11147914B2 (en) | 2013-07-19 | 2021-10-19 | Bigfoot Biomedical, Inc. | Infusion pump system and method |
US11464906B2 (en) | 2013-12-02 | 2022-10-11 | Bigfoot Biomedical, Inc. | Infusion pump system and method |
US11471598B2 (en) | 2015-04-29 | 2022-10-18 | Bigfoot Biomedical, Inc. | Operating an infusion pump system |
FR3134511A1 (en) * | 2022-04-18 | 2023-10-20 | Allerclear | lancet, particularly for allergy tests |
US11865299B2 (en) | 2008-08-20 | 2024-01-09 | Insulet Corporation | Infusion pump systems and methods |
Citations (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SU232454A1 (en) * | Казанский филиал Всесоюзного научно исследовательского института | TOOL FOR VACCINATION | ||
US2522309A (en) * | 1948-12-01 | 1950-09-12 | Frank A Simon | Allergy testing instrument |
FR1309352A (en) * | 1961-10-03 | 1962-11-16 | New device to perform vaccination or medical tests | |
US3246647A (en) * | 1962-07-23 | 1966-04-19 | American Cyanamid Co | Disposable intracutaneous injector |
FR1461996A (en) * | 1964-12-28 | 1966-12-09 | Behringwerke Ag | Device for intradermal application |
US3291129A (en) * | 1962-08-10 | 1966-12-13 | Burelle Pierre Laurent Raymond | Scarificator for use in vaccination, skin tests, or the like |
US3322121A (en) * | 1965-11-26 | 1967-05-30 | Oscar H Banker | Skin-puncturing unit with a collapsible protective cover |
US3465717A (en) * | 1965-03-04 | 1969-09-09 | Lincoln Lab Inc | Immersion means including work holder |
US3470011A (en) * | 1967-02-07 | 1969-09-30 | American Cyanamid Co | Process for applying liquid biologicals to applicators for intracutaneous injection |
US3510933A (en) * | 1967-05-26 | 1970-05-12 | American Cyanamid Co | Apparatus and method for continuously forming intracutaneous injectors |
US3556080A (en) * | 1968-04-08 | 1971-01-19 | Lincoln Lab Inc | Skin allergy testing device |
US3596660A (en) * | 1969-05-12 | 1971-08-03 | Illinois Tool Works | Injection device |
-
1970
- 1970-08-20 US US65424A patent/US3688764A/en not_active Expired - Lifetime
Patent Citations (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SU232454A1 (en) * | Казанский филиал Всесоюзного научно исследовательского института | TOOL FOR VACCINATION | ||
US2522309A (en) * | 1948-12-01 | 1950-09-12 | Frank A Simon | Allergy testing instrument |
FR1309352A (en) * | 1961-10-03 | 1962-11-16 | New device to perform vaccination or medical tests | |
US3246647A (en) * | 1962-07-23 | 1966-04-19 | American Cyanamid Co | Disposable intracutaneous injector |
US3291129A (en) * | 1962-08-10 | 1966-12-13 | Burelle Pierre Laurent Raymond | Scarificator for use in vaccination, skin tests, or the like |
FR1461996A (en) * | 1964-12-28 | 1966-12-09 | Behringwerke Ag | Device for intradermal application |
US3465717A (en) * | 1965-03-04 | 1969-09-09 | Lincoln Lab Inc | Immersion means including work holder |
US3322121A (en) * | 1965-11-26 | 1967-05-30 | Oscar H Banker | Skin-puncturing unit with a collapsible protective cover |
US3470011A (en) * | 1967-02-07 | 1969-09-30 | American Cyanamid Co | Process for applying liquid biologicals to applicators for intracutaneous injection |
US3510933A (en) * | 1967-05-26 | 1970-05-12 | American Cyanamid Co | Apparatus and method for continuously forming intracutaneous injectors |
US3556080A (en) * | 1968-04-08 | 1971-01-19 | Lincoln Lab Inc | Skin allergy testing device |
US3596660A (en) * | 1969-05-12 | 1971-08-03 | Illinois Tool Works | Injection device |
Cited By (82)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1980000531A1 (en) * | 1978-09-05 | 1980-04-03 | L Brennan | Allergy testing system |
US4205689A (en) * | 1978-09-05 | 1980-06-03 | Aller-Screen, Inc. | Allergy testing system |
US4304241A (en) * | 1978-09-05 | 1981-12-08 | Aller-Screen, Inc. | Skin testing device |
US4222392A (en) * | 1979-05-23 | 1980-09-16 | Alier-Screen, Inc. | Allergy testing device with vented base |
US4270548A (en) * | 1979-09-05 | 1981-06-02 | Aller-Screen, Inc. | Allergy testing method |
EP0053206A1 (en) * | 1980-11-27 | 1982-06-09 | Isadore Pitesky | Injection assembly |
US4796624A (en) * | 1986-11-19 | 1989-01-10 | Concept, Inc. | Lashliner |
US5931794A (en) * | 1997-10-21 | 1999-08-03 | Pitesky; Isadore | Allergy testing apparatus |
US6077229A (en) * | 1997-10-21 | 2000-06-20 | Pitesky; Isadore | Allergy testing apparatus |
US5820562A (en) * | 1997-11-05 | 1998-10-13 | Hsiao; Ray-Ling | Skin allergy test device having step-shaped punctures |
CN100411700C (en) * | 2001-10-05 | 2008-08-20 | 贝克顿迪肯森公司 | Microdevice and method of delivering or withdrawing a substance through the skin of an animal |
WO2003030984A1 (en) * | 2001-10-05 | 2003-04-17 | Becton, Dickinson And Company | Microdevice and method of delivering or withdrawing a substance through the skin of an animal |
US6689100B2 (en) * | 2001-10-05 | 2004-02-10 | Becton, Dickinson And Company | Microdevice and method of delivering or withdrawing a substance through the skin of an animal |
US20050187521A1 (en) * | 2002-01-15 | 2005-08-25 | 3M Innovative Properties Company | Microneedle devices and methods of manufacture |
WO2004020014A2 (en) * | 2002-08-30 | 2004-03-11 | Becton, Dickinson And Company | Method of controlling pharmacokinetics of immunomodulatory compounds |
US20040082934A1 (en) * | 2002-08-30 | 2004-04-29 | Pettis Ronald J. | Method of controlling pharmacokinetics of immunomodulatory compounds |
WO2004020014A3 (en) * | 2002-08-30 | 2004-07-01 | Becton Dickinson Co | Method of controlling pharmacokinetics of immunomodulatory compounds |
US20070134719A1 (en) * | 2002-08-30 | 2007-06-14 | Becton, Dickinson And Company | Method of controlling pharmacokinetics of immunomodulatory compounds |
US9682198B2 (en) | 2003-08-28 | 2017-06-20 | Becton, Dickinson And Company | Intradermal injection device |
US20070083151A1 (en) * | 2003-12-29 | 2007-04-12 | Carter Chad J | Medical devices and kits including same |
US20080039805A1 (en) * | 2004-06-10 | 2008-02-14 | Frederickson Franklyn L | Patch Application Device and Kit |
US8057842B2 (en) | 2004-11-18 | 2011-11-15 | 3M Innovative Properties Company | Method of contact coating a microneedle array |
US8758298B2 (en) | 2004-11-18 | 2014-06-24 | 3M Innovative Properties Company | Low-profile microneedle array applicator |
US7846488B2 (en) | 2004-11-18 | 2010-12-07 | 3M Innovative Properties Company | Masking method for coating a microneedle array |
US8414959B2 (en) | 2004-11-18 | 2013-04-09 | 3M Innovative Properties Company | Method of contact coating a microneedle array |
US8267889B2 (en) | 2004-11-18 | 2012-09-18 | 3M Innovative Properties Company | Low-profile microneedle array applicator |
US9174035B2 (en) | 2004-11-18 | 2015-11-03 | 3M Innovative Properties Company | Microneedle array applicator and retainer |
US20080102192A1 (en) * | 2004-11-18 | 2008-05-01 | Johnson Peter R | Masking Method for Coating a Microneedle Array |
US8741377B2 (en) | 2004-11-18 | 2014-06-03 | 3M Innovative Properties Company | Method of contact coating a microneedle array |
US10035008B2 (en) | 2005-04-07 | 2018-07-31 | 3M Innovative Properties Company | System and method for tool feedback sensing |
US20080195035A1 (en) * | 2005-06-24 | 2008-08-14 | Frederickson Franklyn L | Collapsible Patch and Method of Application |
US10315021B2 (en) | 2005-06-24 | 2019-06-11 | 3M Innovative Properties Company | Collapsible patch and method of application |
US20100222743A1 (en) * | 2005-06-27 | 2010-09-02 | Frederickson Franklyn L | Microneedle array applicator device and method of array application |
US9789249B2 (en) | 2005-06-27 | 2017-10-17 | 3M Innovative Properties Company | Microneedle array applicator device and method of array application |
US8784363B2 (en) | 2005-06-27 | 2014-07-22 | 3M Innovative Properties Company | Microneedle array applicator device and method of array application |
US9314569B2 (en) | 2005-09-26 | 2016-04-19 | Bigfoot Biomedical, Inc. | Dispensing fluid from an infusion pump system |
US8480623B2 (en) | 2005-09-26 | 2013-07-09 | Asante Solutions, Inc. | Method for dispensing fluid from an infusion pump system |
US10603431B2 (en) | 2005-09-26 | 2020-03-31 | Bigfoot Biomedical, Inc. | Dispensing fluid from an infusion pump system |
US9814830B2 (en) | 2005-09-26 | 2017-11-14 | Bigfoot Biomedical, Inc. | Dispensing fluid from an infusion pump system |
US8282601B2 (en) | 2005-09-26 | 2012-10-09 | Asante Solutions, Inc. | Dispensing fluid from an infusion pump system |
US8372039B2 (en) | 2005-11-08 | 2013-02-12 | Asante Solutions, Inc. | Infusion pump system |
US8475408B2 (en) * | 2005-11-08 | 2013-07-02 | Asante Solutions, Inc. | Infusion pump system |
US8679060B2 (en) | 2005-11-08 | 2014-03-25 | Asante Solutions, Inc. | Infusion pump system |
US8430847B2 (en) | 2005-11-08 | 2013-04-30 | Asante Solutions, Inc. | Infusion pump system |
US9119945B2 (en) | 2006-04-20 | 2015-09-01 | 3M Innovative Properties Company | Device for applying a microneedle array |
US20090198189A1 (en) * | 2006-04-20 | 2009-08-06 | 3M Innovative Properties Company | Device for applying a microneedle array |
US8551046B2 (en) | 2006-09-18 | 2013-10-08 | Asante Solutions, Inc. | Dispensing fluid from an infusion pump system |
US8409221B2 (en) | 2008-04-17 | 2013-04-02 | Allergan, Inc. | Implantable access port device having a safety cap |
US8398654B2 (en) | 2008-04-17 | 2013-03-19 | Allergan, Inc. | Implantable access port device and attachment system |
US9023063B2 (en) | 2008-04-17 | 2015-05-05 | Apollo Endosurgery, Inc. | Implantable access port device having a safety cap |
US9023062B2 (en) | 2008-04-17 | 2015-05-05 | Apollo Endosurgery, Inc. | Implantable access port device and attachment system |
US11865299B2 (en) | 2008-08-20 | 2024-01-09 | Insulet Corporation | Infusion pump systems and methods |
US8506532B2 (en) | 2009-08-26 | 2013-08-13 | Allergan, Inc. | System including access port and applicator tool |
US8715158B2 (en) | 2009-08-26 | 2014-05-06 | Apollo Endosurgery, Inc. | Implantable bottom exit port |
US8708979B2 (en) | 2009-08-26 | 2014-04-29 | Apollo Endosurgery, Inc. | Implantable coupling device |
US8882728B2 (en) | 2010-02-10 | 2014-11-11 | Apollo Endosurgery, Inc. | Implantable injection port |
US9125718B2 (en) | 2010-04-30 | 2015-09-08 | Apollo Endosurgery, Inc. | Electronically enhanced access port for a fluid filled implant |
US9241819B2 (en) | 2010-04-30 | 2016-01-26 | Apollo Endosurgery, Inc. | Implantable device to protect tubing from puncture |
US8992415B2 (en) | 2010-04-30 | 2015-03-31 | Apollo Endosurgery, Inc. | Implantable device to protect tubing from puncture |
US9192501B2 (en) | 2010-04-30 | 2015-11-24 | Apollo Endosurgery, Inc. | Remotely powered remotely adjustable gastric band system |
US8905916B2 (en) | 2010-08-16 | 2014-12-09 | Apollo Endosurgery, Inc. | Implantable access port system |
US8882655B2 (en) | 2010-09-14 | 2014-11-11 | Apollo Endosurgery, Inc. | Implantable access port system |
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US8821373B2 (en) | 2011-05-10 | 2014-09-02 | Apollo Endosurgery, Inc. | Directionless (orientation independent) needle injection port |
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US9199069B2 (en) | 2011-10-20 | 2015-12-01 | Apollo Endosurgery, Inc. | Implantable injection port |
US8858421B2 (en) | 2011-11-15 | 2014-10-14 | Apollo Endosurgery, Inc. | Interior needle stick guard stems for tubes |
US9089395B2 (en) | 2011-11-16 | 2015-07-28 | Appolo Endosurgery, Inc. | Pre-loaded septum for use with an access port |
US8469900B2 (en) | 2011-11-30 | 2013-06-25 | Lincoln Diagnostics, Inc. | Allergy testing device and method of testing for allergies |
US10470698B2 (en) | 2011-11-30 | 2019-11-12 | Lincoln Diagnostics, Inc. | Allergy testing device and method of testing for allergies |
US9011350B2 (en) | 2011-11-30 | 2015-04-21 | Lincoln Diagnostics, Inc. | Allergy testing device and method of testing for allergies |
US9504418B2 (en) | 2011-11-30 | 2016-11-29 | Lincoln Diagnostics, Inc. | Allergy testing device and method of testing for allergies |
US11529092B2 (en) | 2011-11-30 | 2022-12-20 | Lincoln Diagnostics, Inc. | Allergy testing device and method of testing for allergies |
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CN102839120B (en) * | 2012-09-27 | 2013-12-18 | 山东棉花研究中心 | Inoculation needle |
US11147914B2 (en) | 2013-07-19 | 2021-10-19 | Bigfoot Biomedical, Inc. | Infusion pump system and method |
US11464906B2 (en) | 2013-12-02 | 2022-10-11 | Bigfoot Biomedical, Inc. | Infusion pump system and method |
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