US20130053954A1 - Accommodating intraocular lens device - Google Patents
Accommodating intraocular lens device Download PDFInfo
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- US20130053954A1 US20130053954A1 US13/662,087 US201213662087A US2013053954A1 US 20130053954 A1 US20130053954 A1 US 20130053954A1 US 201213662087 A US201213662087 A US 201213662087A US 2013053954 A1 US2013053954 A1 US 2013053954A1
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- iol device
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/14—Eye parts, e.g. lenses, corneal implants; Implanting instruments specially adapted therefor; Artificial eyes
- A61F2/16—Intraocular lenses
- A61F2/1613—Intraocular lenses having special lens configurations, e.g. multipart lenses; having particular optical properties, e.g. pseudo-accommodative lenses, lenses having aberration corrections, diffractive lenses, lenses for variably absorbing electromagnetic radiation, lenses having variable focus
- A61F2/1624—Intraocular lenses having special lens configurations, e.g. multipart lenses; having particular optical properties, e.g. pseudo-accommodative lenses, lenses having aberration corrections, diffractive lenses, lenses for variably absorbing electromagnetic radiation, lenses having variable focus having adjustable focus; power activated variable focus means, e.g. mechanically or electrically by the ciliary muscle or from the outside
- A61F2/1635—Intraocular lenses having special lens configurations, e.g. multipart lenses; having particular optical properties, e.g. pseudo-accommodative lenses, lenses having aberration corrections, diffractive lenses, lenses for variably absorbing electromagnetic radiation, lenses having variable focus having adjustable focus; power activated variable focus means, e.g. mechanically or electrically by the ciliary muscle or from the outside for changing shape
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/14—Eye parts, e.g. lenses, corneal implants; Implanting instruments specially adapted therefor; Artificial eyes
- A61F2/16—Intraocular lenses
- A61F2002/1681—Intraocular lenses having supporting structure for lens, e.g. haptics
- A61F2002/1682—Intraocular lenses having supporting structure for lens, e.g. haptics having mechanical force transfer mechanism to the lens, e.g. for accommodating lenses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/14—Eye parts, e.g. lenses, corneal implants; Implanting instruments specially adapted therefor; Artificial eyes
- A61F2/16—Intraocular lenses
- A61F2002/1681—Intraocular lenses having supporting structure for lens, e.g. haptics
- A61F2002/16901—Supporting structure conforms to shape of capsular bag
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2250/00—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2250/0014—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof having different values of a given property or geometrical feature, e.g. mechanical property or material property, at different locations within the same prosthesis
- A61F2250/0018—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof having different values of a given property or geometrical feature, e.g. mechanical property or material property, at different locations within the same prosthesis differing in elasticity, stiffness or compressibility
Definitions
- the invention relates generally to an accommodating intraocular lens device and, more particularly, to an accommodating intraocular lens device configured for implantation in a lens capsule of a subject's eye.
- a cataract is a clouding of the lens in the eye that affects vision. While most cataracts are related to aging, cataracts may also develop as a result of traumatic eye injury, glaucoma, diabetes, steroid use, and exposure to radiation, to name a few. If left untreated, cataracts progress to eventual vision loss and even complete blindness.
- Cataracts are typically treated by surgically removing the clouded lens matrix and implanting a replacement artificial intraocular lens (IOL) in the lens capsule that remains.
- IOL intraocular lens
- the first generation of implanted IOL devices comprised monofocal lenses, which provided vision correction at only a single distance. Thus, while monofocal lenses provided distance vision, corrective lenses were still required for reading.
- Multifocal lenses for IOL devices were introduced to provide vision correction at more than one distance with the goal of obviating the need for additional corrective lenses required with the monofocal lenses.
- Multifocal lenses typically have areas of varying refractive power to provide vision at multiple distances (e.g., near, intermediate and far).
- One significant disadvantage to multifocal lenses is the possibility of visual distortions, particularly in the form of glare and halos around light sources at night.
- Accommodating IOL devices have recently been introduced as yet another alternative IOL for use in cataract surgery.
- Accommodating IOL devices typically feature a monofocal lens that is configured to move forward and backward within the eye in response to the eye's natural mechanism of accommodation, thereby allowing the eye to focus on objects across a broad range of distances.
- Crystalens® by Bausch and Lomb is the only FDA-approved accommodating IOL on the market in the United States.
- This device comprises a relatively flat central lens and a pair hinged haptics protruding from the central lens. The haptics respond to the contraction and relaxation of the eye's ciliary muscles to move the central lens portion forward and backward within the eye to provide varying dioptres of power.
- the Crystalens® device relies solely on the eye's ciliary muscle function in order to provide accommodation. Moreover, because the profile of the Crystalens® device is substantially smaller than that of the natural lens capsule, implantation of this device is followed by shrinkage of the natural lens capsule about the device. As the natural lens capsule shrinks, the zonules are further stretched away from the ciliary muscles, with the attendant loss of the eye's accommodative range.
- Dual-lens IOL devices have been developed with the goal of providing a broader range of accommodation that is closer to the eye's natural range.
- the dual-lens IOL devices typically feature an anterior and a posterior lens in a spaced relation and rely solely on the ciliary muscles to actuate the anterior and posterior lens closer or farther together to alter the distance between them. The varying distance between the anterior and posterior lens provides the accommodation.
- Examples of dual-lens IOL devices include U.S. Pat. No. 5,275,623, issued to Sarfarazi on Jan. 4, 1994 and U.S. Pub. No. 2006/0178741 to Zadno-Azizi et al., published on Aug. 10, 2006.
- Dual-lens IOL devices generally suffer the disadvantage of being more complicated in design and requiring larger incisions in the eye for implantation. While the dual-lens IOL devices may hold the potential for providing a greater range of accommodation, they represent a radical departure from the natural lens structure of the eye.
- IOL devices While accommodating IOL devices hold the promise of more fully restoring the natural range of vision for cataract patients, they still fail to substantially mimic the eye's natural mechanism of accommodation. This is primarily because they rely solely on the eye's ciliary muscles to provide the accommodation and fail to respond to other forces which influence the natural accommodative process.
- Preferred embodiments of the accommodating intraocular lens (IOL) devices disclosed herein substantially mimic the eye's natural mechanism of accommodation by responding not only to the contraction/relaxation of the ciliary muscles but also to the influence of the viscous body, which bulges forward and exerts a force anteriorly to change the curvature of the lens capsule.
- the accommodating IOL devices disclosed herein provide a broader range of accommodation that approximates that found in the natural eye.
- an accommodating IOL device adapted for implantation in the lens capsule of a subject's eye.
- the accommodating IOL device comprises an anterior portion having a refractive optical element, an elastic posterior portion; and an enclosed cavity defined between the anterior and posterior portions.
- the enclosed cavity is configured to contain a volume of fluid to space apart the anterior and posterior portions.
- the posterior portion is configured to contact the posterior portion of the lens bag (prior to shrinkage of the lens capsule following implantation) which in turn contacts the vitreous body at least in the area at and surrounding the optical axis when the IOL device is implanted in the eye and the cavity contains the fluid.
- the posterior portion actuates in response to an anterior force exerted by the vitreous body, causing the fluid to exert a deforming or displacing force on the refractive optical element.
- the refractive optical element increases its degree of curvature in response to the anterior force and decreases its degree of curvature in the absence of the anterior force.
- the refractive optical element is resiliently biased to having a degree of curvature that is substantially equal to the degree of curvature of the anterior portion of the subject's natural lens capsule.
- the IOL device is biased to a configuration having a width that is substantially equal to the width of the unaccommdated natural lens capsule along the optical axis.
- the IOL device has an equatorial diameter that is substantially equal to the equatorial diameter of the subject's natural lens capsule in the unaccommodated state.
- the anterior portion is dimensioned to engage the zonules when the IOL device is implanted in the subject's eye.
- the IOL device further comprises a haptic system coupled to the anterior portion.
- the haptic system may be configured to substantially center the refractive optical element in the path of the optical axis when implanted in the subject's eye.
- the haptic system is configured to bilaterally displace the refractive optical element along the optical axis in response to the contraction and relaxation of the ciliary muscles when the IOL device is implanted in the subject's eye.
- the volume of fluid contained in the cavity is sufficient to space apart the anterior and posterior portions at a distance d 3 along the optical axis that is substantially equal to the width of the subject's natural lens capsule along the optical axis d 2 in the unaccommodated state.
- an accommodating IOL device adapted for implantation in the lens capsule of a subject's eye.
- the accommodating IOL device comprises an anterior refractive optical element and a membrane comprising a posterior surface.
- the membrane is coupled to the anterior optical element and defines an enclosed cavity configured to contain a volume of fluid.
- the posterior portion is configured to contact the posterior portion of the lens capsule which in turn contacts the vitreous body at least in an area at and surrounding the optical axis when the IOL device is implanted in the eye and the cavity contains the fluid.
- the fluid deforms the anterior refractive optical element in response to an anterior force exerted on the posterior surface by the vitreous body.
- the anterior optical element further comprises a self-sealing valve to permit the injection of the fluid.
- the fluid is viscoelastic.
- the fluid is an aqueous solution of saline or hyaluronic acid.
- the fluid has substantially the same viscosity as the vitreous humor.
- the fluid has substantially the same refractive index as the aqueous humor or the vitreous humor.
- the membrane is coupled to the anterior refractive optical element about its periphery.
- the anterior refractive optical element is contained within the enclosed cavity of the membrane.
- the posterior portion further comprises a reinforced portion.
- a method for implanting an accommodating intraocular accommodating lens (IOL) device in a subject's eye comprises introducing an IOL device in the lens capsule of the subject's eye through an incision in the subject's eye, wherein the IOL device comprises a refractive optical element coupled to an elastic membrane to define an internal cavity; positioning the IOL device within the lens capsule of the subject's eye to substantially center the refractive optical element along an optical axis; and injecting a volume of fluid into the internal cavity of the IOL device sufficient to cause the elastic membrane to contact the posterior portion of the lens capsule which in turn contacts the vitreous body in at least an area at and surrounding the optical axis.
- IOL intraocular accommodating lens
- FIGS. 1A and B are sectional views illustrating the certain anatomical features of the human eye with the lens in the unaccommodated and accommodated states, respectively.
- FIGS. 2A , B and C are cut-away perspective, plan and cross-sectional views, respectively, of an embodiment of a refractive optical element coupled to a fluid-filled lens capsule.
- FIGS. 3A and B are plan and side views, respectively, of an embodiment of a refractive optical element and haptic system.
- FIGS. 4A , B and C are cut-away perspective, plan and cross-sectional views, respectively, of an embodiment of a refractive optical element and haptic system of FIGS. 3A-B coupled to a fluid filled lens capsule.
- FIGS. 5A and B are plan and side views, respectively, of another embodiment of a refractive optical element and haptic system.
- FIGS. 6A , B and C are cut-away perspective, plan and cross-sectional views, respectively, of another embodiment of a refractive optical element and haptic system of FIGS. 5A-B coupled to a fluid-filled lens capsule.
- FIG. 7 depicts an embodiment of the intraocular lens device implanted in the posterior chamber of a human eye.
- the human eye 100 comprises three chambers of fluid: the anterior chamber 112 , the posterior chamber 120 and the vitreous chamber 160 .
- the anterior chamber 112 corresponds generally to the space between the cornea 110 and the iris 114 and the posterior chamber 120 corresponds generally to the space bounded by the iris 114 , the lens 130 and zonule fibers 140 connected to the periphery of the lens 130 .
- the anterior chamber 112 and the posterior chamber 120 contain a fluid known as the aqueous humor, which flows therebetween through an opening that is defined by the iris 114 , known as the pupil 116 .
- the iris 114 regulates the amount of light entering the eye 100 by controlling the size of the pupil 116 .
- the vitreous chamber 160 is located between the lens 130 and the retina 170 and contains another fluid, known as the vitreous humor.
- the vitreous humor is much more viscous than the aqueous humor and is a transparent, colorless, gelatinous mass.
- much of the volume of the vitreous humor is water, it also contains cells, salts, sugars, vitrosin (a type of collagen), a network of collagen type II fibers with the glycosaminoglycan hyaluronic acid, and proteins.
- the vitreous has a viscosity two to four times that of pure water, giving it a gelatinous consistency. It also has a refractive index of 1.336.
- the vitreous humor is stagnant.
- the vitreous often becomes less viscous and may even collapse as part of the aging process. It is believed that the collagen fibers of the vitreous humor are held apart by electrical charges. With aging, these charges tend to reduce, and the fibers may clump together.
- the vitreous humor may liquefy, a condition known as syneresis, allowing cells and other organic clusters to float freely within the vitreous humor. These allow floaters which are perceived in the visual field as spots or fibrous strands.
- the lens 130 is a clear, crystalline protein membrane-like structure that is quite elastic, a quality that keeps it under constant tension via the attached zonules 140 and ciliary muscles 150 .
- the lens 130 naturally tends towards a rounder configuration, a shape it must assume for the eye 100 to focus at a near distance as shown in FIG. 1B .
- the lens functions to change the focus distance of the eye so that it can focus on objects at various distances, thus allowing a real image of the object of interest to be formed on the retina.
- the lens 130 may be characterized as a capsule having two surfaces: an anterior surface 132 and a posterior surface 134 .
- the anterior surface 132 faces the posterior chamber 120 and the posterior surface 134 faces the vitreous body 160 .
- the posterior surface 134 contacts the vitreous body 160 in such a manner that fluid movements within the vitreous body 160 are communicated to the posterior surface 134 and may cause the shape of the lens 130 to change.
- the eye's natural mechanism of accommodation is reflected by the changes in shape of the lens 130 and thus the extent to which it refracts light.
- FIG. 1A shows the eye 100 in a relatively unaccommodated state, as may be the case when the eye is focusing at a distance.
- the ciliary muscles 150 relax, thereby increasing the diameter of its opening and causing the zonules to be pulled away from the visual axis A-A.
- This causes the zonules 140 to radially pull on the periphery of the lens 130 and cause the lens 130 to flatten.
- the shape of the lens 130 is flattened, its ability to bend or refract light entering the pupil is reduced.
- the lens 130 has a flatter surface, its diameter e 1 along the equatorial axis B-B is lengthened and its thickness d 1 along the visual axis A-A is decreased, all relative to the accommodated state (compare e 2 and d 2 in FIG. 1A ).
- FIG. 1B shows the eye 100 in a relatively accommodated state, as may be the case when the eye is focusing on a nearby object.
- the ciliary muscles 150 contract, and the contraction of the ciliary muscles 150 causes them to move in an anterior direction. This, in turn, reduces the stress on the zonules 140 , thereby lessening the stress exerted by the zonules 140 on the lens 130 .
- the lens 130 thereupon undergoes elastic recovery and rebounds to a more relaxed and accommodated state, in which the lens 130 has a more convex anterior surface, its diameter e 2 along the equatorial axis B-B is decreased and its thickness d 2 along the visual axis A-A is increased relative to the unaccommodated state (compare e 2 and d 1 in FIG. 1A ).
- FIG. 1B depicts the anterior and posterior surfaces 132 , 134 of the lens capsule 130 as having roughly the same radius of curvature, it is believed that during accommodation, the radius of curvature for the anterior surface 132 increases and the radius of curvature of the posterior surface 134 is not significantly changed from its unaccommodated state.
- the vitreous body 160 also plays a significant role, primarily due to the nature of the contact between the posterior surface 134 of the lens 130 and the vitreous body 160 , in which the posterior surface 134 responds to and transmits anterior fluid movement in the vitreous body 160 to effectuate changes in shape of the lens 130 .
- FIGS. 2A-C illustrate an embodiment of an accommodating IOL device 200 that may be implanted into the lens capsule 130 of the eye following cataract removal.
- the IOL device 200 is shown to comprise an optical element 210 and a flexible membrane 230 coupled to the optical element 210 .
- the optical element 210 and the flexible membrane 230 together define an interior cavity 220 which may be filled with fluid.
- the optical element 210 may further optionally comprise an injection port 212 to permit the injection of the fluid to fill the cavity 220 .
- the injection port 212 comprises a one-way valve and is self-sealing.
- a separate plug (not shown) may be provided to seal off the injection port 212 . While FIGS. 2-7 depict the injection port 212 as being located within the optical element 210 , it is understood that the placement of the injection port 212 is not critical, so long as its placement does not impede vision.
- the optical element 210 may be made of plastic, silicone, acrylic, or a combination thereof.
- the optical element 210 is made of poly(methyl methacrylate) (PMMA), which is a transparent thermoplastic, sometimes called acrylic glass. Because the optical element 210 is responsible for providing most, if not substantially all, of the refractive power of the IOC device, the optical element 210 is preferably sufficiently flexible so as to change its curvature in response to the contraction/relaxation of the anterior force that is exerted when the vitreous body bulges in the anterior direction.
- PMMA poly(methyl methacrylate)
- the optical element 210 is resiliently biased to a shape that approximates the shape of a natural and unaccommodated lens (see FIG. 1A ).
- the optical element 210 accordingly increases its degree of curvature in response to the anterior force exerted by the vitreous body and is resiliently biased to a flatter configuration or a decreased degree of curvature, similar to the configuration of the natural lens in the unaccommodated state, in the absence of the anterior force.
- the optical element 210 is resiliently biased to a shape that approximates the shape of a natural and accommodated lens (see FIG. 1B ).
- the optical element 210 accordingly is resiliently biased to a convex configuration similar to that of the natural lens in the accommodated state and assumes a less convex configuration as the ciliary muscles 150 relax and the tension of the zonules 140 on the lens capsule 130 increases.
- the optical element 210 has a disk shape of sufficient diameter to engage the zonules 140 of the eye. As this dimension may differ from patient to patient, it is contemplated that the optical element 210 be provided in a range of sizes to fit a patient's anatomy. In other embodiments, the optical element 210 may further comprise a separate haptic system ( FIGS. 3-6 ) to engage the zonules 140 of the eye. In these embodiments, the optical element 210 may have a diameter that is significantly smaller than the embodiments in which the optical element 210 directly engages the zonules 140 of the eye.
- the IOL device responds to part of the accommodative mechanism of the eye in which the ciliary muscles 150 and the zonules 140 cause a bilateral movement of the optical element 210 along the optical axis to thereby provide part of the accommodating response.
- the accommodating IOL device 200 is additionally configured to allow the optical clement 210 change its shape in response to the forces exerted upon it by the vitreous body 160 .
- This is achieved by providing a flexible optical element 210 and a fluid-filled flexible membrane 230 that is configured to transmit the anterior force of the vitreous body 160 during accommodation to affect the changes in the shape of the lens capsule 130 .
- the membrane 230 contacts a substantial area of the posterior surface 134 of the lens capsule 130 and the membrane is sufficiently flexible and substantially devoid of any rigid material that would prevent it from responding to the anterior movements of the vitreous body 160 .
- the accommodating IOL device 200 is distinguishable from prior art dual lens IOL devices in maintaining a flexible boundary between the lens capsule 130 and the vitreous body 160 .
- the membrane 230 is sufficiently thin and deformable so as not to impede the natural flexible boundary between the lens capsule 130 and the vitreous body 160 .
- the IOL device minimizes the degree to which this shrinkage occurs by significantly engaging the contours of the lens capsule 130 , particularly the posterior surface 134 of the lens capsule 130 via the fluid filled cavity 220 defined by the optical element 210 and membrane 230 .
- the membrane 230 is preferably configured to contact a substantial, if not substantially all, of the posterior surface 134 of the lens capsule 130 at implantation and before any significant shrinkage of the lens capsule 130 has occurred.
- the vitreous body 160 exerts a force in the anterior direction along the optical axis A-A and pushes the lens capsule 130 in the anterior direction. This, in turn, causes the anterior surface 132 of the lens capsule 130 to become more curved and thus to further refract the light.
- the optical element 210 is responsible for providing most, if not substantially all, of the refractive power of the IOC device, the optical element 210 is preferably sufficiently flexible so as to change its curvature in response to the contraction/relaxation of the anterior force that is exerted when the vitreous body bulges in the anterior direction.
- the optical element 210 is resiliently biased to a shape that approximates the shape of a natural and unaccommodated lens (see FIG. 1A ).
- the optical element 210 accordingly increases its degree of curvature in response to the anterior force exerted by the vitreous body and is resiliently biased to a flatter configuration or a decreased degree of curvature, similar to the configuration of the natural lens in the unaccommodated state, in the absence of the anterior force.
- the flexible membrane 230 may be constructed from any biocompatible elastomeric material.
- the flexible membrane 230 has an external surface that approximates the posterior surface of the lens capsule adjacent the vitreous body.
- the flexible membrane 230 is preferably configured and shaped to contact a substantial, if not the entire, area of the posterior surface of the lens capsule. In a particularly preferred embodiment, this point of contact is at and around the optical axis of the posterior surface.
- the flexible membrane 230 is preferably configured to maximize this transfer of force from the vitreous body to the lens 122 .
- the anterior portion 132 of the lens 130 of the unaccommodated eye 100 in FIG. 1A has a lesser degree of curvature (i.e., is flatter) than that of the accommodated eye 100 of FIG. 1B .
- the vitreous body is believed to exert an anterior force along the optical axis on the lens 122 to effectuate a greater degree of curvature, it is preferable to maximize transfer of force resulting from anterior vitreous movement onto the lens 122 .
- the flexible membrane 230 may have areas of greater and lesser elasticity so as to maximize the translation of the anterior movements of the vitreous body.
- the flexible membrane 230 may comprise a central posterior portion 224 (corresponding to an area surrounding the optical axis A-A when the IOL device 200 is implanted) having greater elasticity than the adjacent circumferential portion 222 . Having areas of reduced elasticity in the adjacent circumferential portion 222 may reduce radial expansion of the membrane 230 and allow the anterior force exerted by the vitreous body 170 to be more effectively translated and applied onto the optical element 210 by the fluid contained in the cavity 220 to thereby increase the curvature of the optical element 210 .
- the IOL device 200 may be configured to resiliently assume a shape having a width d 3 that is substantially equal to the width the lens capsule 130 accommodated eye (see d 2 of FIG. 1B ) when it is implanted in the patient's eye. This may be achieved by constructing the IOL device 200 with resilient materials having some degree of shape memory and also by filling the cavity 220 with a volume of fluid sufficient to expand the flexible membrane 230 to the desired width, d 3 .
- the IOL device 200 comprises a single lens.
- the incorporation of additional lenses in the IOL device would likely interfere with the ability of the lens to deform (i.e., increase its curvature and provide additional diopters of power) to anterior vitreous movement.
- the flexible membrane may preferably be made from a polyvinylidene fluoride (PDVF) material. PDVF is believed to allow for the transmission of lasers energy without, itself, becoming degraded.
- a reinforced portion 234 of the flexible membrane 230 may optionally be provided to resist degradation upon the application of lasers of various wavelengths.
- the reinforced section 234 is positioned at an area on the membrane 230 corresponding to the optical axis A-A when the IOL device 200 is implanted in the subject's eye.
- a few of the residual epithelial cells in the lens capsule may migrate to a posterior surface of the bag resulting in various degrees of fibrosis which, in turn, may lead to undesired posterior capsule opacification (PCO).
- PCO posterior capsule opacification
- a reinforced portion 234 may be provided on the membrane 230 as a protective mechanism against the potentially degradative effects of laser treatment on the membrane 230 .
- the reinforced portion 234 remains flexible and is sized to correspond to the central area at and surrounding the optical axis A-A.
- the fluid is an aqueous solution of saline or hyaluronic acid and does not provide a significant, or any, contribution to the refractive power of the IOC device.
- the function of the fluid is primarily as a vehicle to transfer force resulting from the movement of the vitreous body 150 onto the optical element 210 to provide the accommodation.
- the fluid has a viscosity that is substantially the same as the vitreous humor.
- the fluid has a refractive index that is substantially the same as the aqueous humor or the vitreous humor.
- the IOL device is distinguishable from prior art teachings in which the lens capsule is with various types of polymers, which are injected in liquid form and set with UV or other methods of polymerization. These attempts have been met with much difficulty as it is often difficult to control the refractive power provided by the polymerized polymers.
- the refractive power is provided substantially, if not entirely, by the optical element 210 and the fluid that is contained within the cavity 220 does not contribute significantly, if at all, to providing the refractive power of the IOL device.
- the fluid is a relatively inert or biocompatible material, such as saline, or it alternatively contains a high molecular weight compound, such as hyaluronic acid, which does not readily leak from the IOL device 200 .
- the precise volume of fluid injected into the cavity 220 may differ based on the subject's anatomy, among other factors.
- the volume of fluid injected into the cavity 220 is not critical so long as it is sufficient to expand the membrane 230 such that the posterior portion of the membrane 230 substantially contacts the posterior portion of the lens capsule and engages the vitreous body of the subject's eye.
- a volume of fluid is injected into the cavity 220 so as to provide a width d 3 of the IOL device along the optical axis A-A substantially approximating the lens width d 2 of the accommodated eye 100 .
- a volume of fluid is injected into the cavity 220 so as to provide a width d 3 of the IOL device along the optical axis AA substantially approximating the width d 1 of the unaccommodated eye 100 .
- a haptic system may be incorporated with the IOL device to position the optical element 210 at the optical axis A-A when implanted in the subject's eye.
- the haptic system preferably comprises a plurality of haptic members extending radially from the IOL device and engaging the zonules 140 surrounding the lens capsule 130 of the eye.
- FIGS. 3A-B depict an optical element 210 comprising a pair of spring haptics 350 coupled to opposing sides of the optical element 210 .
- a flexible membrane 230 may be coupled to the optical element 210 /haptic 350 assembly along the periphery of the optical element 210 .
- a seal is effectuated between the flexible membrane 230 and the periphery of the optical element 210 by laser welding and any other means known to those of skill in the art.
- the optical element 210 may be contained within a flexible membrane 230 that fully encloses the optical element 210 .
- flexible membrane 230 has a bag or balloon-like configuration and the spring haptics 350 may be attached either (1) to the optical element 210 itself and protrude from a sealed opening in the flexible membrane 230 or (2) to the flexible membrane 230 .
- FIGS. 3-4 depict a pair of spring haptics 350 extending radially from the optical element 210 , it is understood that any number of spring haptics 350 may be provided so long as optical element 210 is centered about the optical axis A-A when the IOL device is implanted in the eye.
- FIGS. 5A-B depict an optical element 210 comprising a pair of plate haptics 450 coupled to opposing sides of the optical element 210 .
- the plate haptics 450 comprise a pair of plate members each comprising a first end 452 attached to the optical element 210 and a second end 456 configured to engage the zonules 140 of the eye 100 when implanted in the lens capsule 130 .
- a hinge 464 is disposed between the first and second ends 452 , 456 , to allow lateral movement of the optical element 210 in the anterior and posterior directions as the ciliary muscles 150 relax and contract, respectively.
- a flexible membrane 230 may be coupled to the optical element 210 /haptic 450 assembly along the periphery of the optical element 210 .
- the optical element 210 may be contained within a flexible membrane 230 that fully encloses the optical element 210 .
- the spring haptics 450 may be attached either (1) to the optical element 210 itself and protrude from a sealed opening in the flexible membrane 230 or (2) to the flexible membrane 230 .
- FIGS. 5-6 depict a pair of plate haptics 450 extending radially from the optical element 210 , it is understood that any number of plate haptics 450 may be provided so long as optical element 210 is centered about the optical axis A-A when the IOL device is implanted in the eye.
- FIG. 7 depicts an embodiment of the accommodating IOL device implanted in the lens capsule 130 of the eye in an accommodated state. Because both the optical element 210 and the membrane 230 of the IOL device 200 is sufficiently flexible, it may be folded or rolled compactly prior to implantation, thereby requiring only a small incision of a few millimeters for insertion into the eye. As shown in FIG. 7 , after the IOL device is implanted and the cavity 220 is filled with fluid, the IOL device is divided roughly in two: the anterior lens portion 210 facing the posterior capsule 120 and the posterior membrane portion 230 facing the vitreous body 160 .
- the width d 3 of the IOL device is resiliently biased to having a width that is roughly equal to the width of the natural lens capsule when it is in an accommodated state (see d 2 of FIG. 1B ).
- the posterior membrane portion 230 has an area of contact that approximates the surface area of the posterior portion 134 of the lens capsule 130 (See FIGS. 1A-B ).
- Two or more haptics 550 are shown to protrude from the IOL device to substantially center the anterior lens portion 210 along the optical axis A-A.
- the accommodated IOL device shown in FIG. 7 is implanted in the lens capsule of a subject's eye by introducing an IOL device in the lens capsule of the subject's eye through a small incision in the subject's eye, wherein the IOL device comprises a refractive optical element 210 coupled to an elastic membrane 230 to define an internal cavity 220 .
- the IOL device is then positioned within the lens capsule 130 of the subject's eye to substantially center the refractive optical element 210 along an optical axis A-A.
- a volume of fluid is then injected into the internal cavity 220 of the IOL device sufficient to cause the elastic membrane 230 to contact the posterior portion of the lens capsule which, in turn, contacts the vitreous body in at least an area at and surrounding the optical axis A-A.
- the volume of fluid injected into the internal cavity 220 is sufficient to produce a width d 3 of the IOL device along the optical axis A-A that is substantially equal to the width of a natural lens capsule in an accommodated state.
Abstract
An accommodating intraocular lens (IOL) device adapted for implantation in the lens capsule of a subject's eye. The IOL device includes an anterior refractive optical element and a membrane coupled to the refractive optical element. The anterior refractive optical element and the membrane define an enclosed cavity configured to contain a fluid. At least a portion of the membrane is configured to contact a posterior area of the lens capsule adjoining the vitreous body of the subject's eye. The fluid contained in the enclosed cavity exerts a deforming or displacing force on the anterior refractive optical element in response to an anterior force exerted on the membrane by the vitreous body. The IOL device may further include a haptic system to position the anterior refractive optical element and also to engage the zonules and ciliary muscles to provide additional means for accommodation.
Description
- The invention relates generally to an accommodating intraocular lens device and, more particularly, to an accommodating intraocular lens device configured for implantation in a lens capsule of a subject's eye.
- A cataract is a clouding of the lens in the eye that affects vision. While most cataracts are related to aging, cataracts may also develop as a result of traumatic eye injury, glaucoma, diabetes, steroid use, and exposure to radiation, to name a few. If left untreated, cataracts progress to eventual vision loss and even complete blindness.
- Cataracts are typically treated by surgically removing the clouded lens matrix and implanting a replacement artificial intraocular lens (IOL) in the lens capsule that remains. The first generation of implanted IOL devices comprised monofocal lenses, which provided vision correction at only a single distance. Thus, while monofocal lenses provided distance vision, corrective lenses were still required for reading.
- Multifocal lenses for IOL devices were introduced to provide vision correction at more than one distance with the goal of obviating the need for additional corrective lenses required with the monofocal lenses. Multifocal lenses typically have areas of varying refractive power to provide vision at multiple distances (e.g., near, intermediate and far). One significant disadvantage to multifocal lenses is the possibility of visual distortions, particularly in the form of glare and halos around light sources at night.
- Accommodating IOL devices have recently been introduced as yet another alternative IOL for use in cataract surgery. Accommodating IOL devices typically feature a monofocal lens that is configured to move forward and backward within the eye in response to the eye's natural mechanism of accommodation, thereby allowing the eye to focus on objects across a broad range of distances. Currently, Crystalens® by Bausch and Lomb is the only FDA-approved accommodating IOL on the market in the United States. This device comprises a relatively flat central lens and a pair hinged haptics protruding from the central lens. The haptics respond to the contraction and relaxation of the eye's ciliary muscles to move the central lens portion forward and backward within the eye to provide varying dioptres of power. The Crystalens® device relies solely on the eye's ciliary muscle function in order to provide accommodation. Moreover, because the profile of the Crystalens® device is substantially smaller than that of the natural lens capsule, implantation of this device is followed by shrinkage of the natural lens capsule about the device. As the natural lens capsule shrinks, the zonules are further stretched away from the ciliary muscles, with the attendant loss of the eye's accommodative range.
- Dual-lens IOL devices have been developed with the goal of providing a broader range of accommodation that is closer to the eye's natural range. The dual-lens IOL devices typically feature an anterior and a posterior lens in a spaced relation and rely solely on the ciliary muscles to actuate the anterior and posterior lens closer or farther together to alter the distance between them. The varying distance between the anterior and posterior lens provides the accommodation. Examples of dual-lens IOL devices include U.S. Pat. No. 5,275,623, issued to Sarfarazi on Jan. 4, 1994 and U.S. Pub. No. 2006/0178741 to Zadno-Azizi et al., published on Aug. 10, 2006. Dual-lens IOL devices generally suffer the disadvantage of being more complicated in design and requiring larger incisions in the eye for implantation. While the dual-lens IOL devices may hold the potential for providing a greater range of accommodation, they represent a radical departure from the natural lens structure of the eye.
- While accommodating IOL devices hold the promise of more fully restoring the natural range of vision for cataract patients, they still fail to substantially mimic the eye's natural mechanism of accommodation. This is primarily because they rely solely on the eye's ciliary muscles to provide the accommodation and fail to respond to other forces which influence the natural accommodative process.
- Preferred embodiments of the accommodating intraocular lens (IOL) devices disclosed herein substantially mimic the eye's natural mechanism of accommodation by responding not only to the contraction/relaxation of the ciliary muscles but also to the influence of the viscous body, which bulges forward and exerts a force anteriorly to change the curvature of the lens capsule. Thus, by providing both bilateral displacement and changes in curvature, the accommodating IOL devices disclosed herein provide a broader range of accommodation that approximates that found in the natural eye.
- In one embodiment, an accommodating IOL device adapted for implantation in the lens capsule of a subject's eye is described. The accommodating IOL device comprises an anterior portion having a refractive optical element, an elastic posterior portion; and an enclosed cavity defined between the anterior and posterior portions. The enclosed cavity is configured to contain a volume of fluid to space apart the anterior and posterior portions. The posterior portion is configured to contact the posterior portion of the lens bag (prior to shrinkage of the lens capsule following implantation) which in turn contacts the vitreous body at least in the area at and surrounding the optical axis when the IOL device is implanted in the eye and the cavity contains the fluid. The posterior portion actuates in response to an anterior force exerted by the vitreous body, causing the fluid to exert a deforming or displacing force on the refractive optical element.
- In accordance with a first aspect of this embodiment, the refractive optical element increases its degree of curvature in response to the anterior force and decreases its degree of curvature in the absence of the anterior force.
- In accordance with a second aspect of this embodiment, the refractive optical element is resiliently biased to having a degree of curvature that is substantially equal to the degree of curvature of the anterior portion of the subject's natural lens capsule.
- In accordance with a third aspect of this embodiment, the IOL device is biased to a configuration having a width that is substantially equal to the width of the unaccommdated natural lens capsule along the optical axis.
- In accordance with a fourth aspect of this embodiment, the IOL device has an equatorial diameter that is substantially equal to the equatorial diameter of the subject's natural lens capsule in the unaccommodated state.
- In accordance with a fifth aspect of this embodiment, the anterior portion is dimensioned to engage the zonules when the IOL device is implanted in the subject's eye.
- In accordance with a sixth aspect of this embodiment, the IOL device further comprises a haptic system coupled to the anterior portion. The haptic system may be configured to substantially center the refractive optical element in the path of the optical axis when implanted in the subject's eye. Alternatively or additionally, the haptic system is configured to bilaterally displace the refractive optical element along the optical axis in response to the contraction and relaxation of the ciliary muscles when the IOL device is implanted in the subject's eye.
- In accordance with a seventh aspect of this embodiment, the volume of fluid contained in the cavity is sufficient to space apart the anterior and posterior portions at a distance d3 along the optical axis that is substantially equal to the width of the subject's natural lens capsule along the optical axis d2 in the unaccommodated state.
- In another embodiment, an accommodating IOL device adapted for implantation in the lens capsule of a subject's eye is described. The accommodating IOL device comprises an anterior refractive optical element and a membrane comprising a posterior surface. The membrane is coupled to the anterior optical element and defines an enclosed cavity configured to contain a volume of fluid. The posterior portion is configured to contact the posterior portion of the lens capsule which in turn contacts the vitreous body at least in an area at and surrounding the optical axis when the IOL device is implanted in the eye and the cavity contains the fluid. The fluid deforms the anterior refractive optical element in response to an anterior force exerted on the posterior surface by the vitreous body.
- In accordance with a first aspect of this embodiment, the anterior optical element further comprises a self-sealing valve to permit the injection of the fluid.
- In accordance with a second aspect of this embodiment, the fluid is viscoelastic.
- In accordance with a third aspect of this embodiment, the fluid is an aqueous solution of saline or hyaluronic acid.
- In accordance with a fourth aspect of this embodiment, the fluid has substantially the same viscosity as the vitreous humor.
- In accordance with a fifth aspect of this embodiment, the fluid has substantially the same refractive index as the aqueous humor or the vitreous humor.
- In accordance with a sixth aspect of this embodiment, the membrane is coupled to the anterior refractive optical element about its periphery.
- In accordance with a seventh aspect of this embodiment, the anterior refractive optical element is contained within the enclosed cavity of the membrane.
- In accordance with a eighth aspect of this embodiment, the posterior portion further comprises a reinforced portion.
- In a further embodiment, a method for implanting an accommodating intraocular accommodating lens (IOL) device in a subject's eye is described. The method comprises introducing an IOL device in the lens capsule of the subject's eye through an incision in the subject's eye, wherein the IOL device comprises a refractive optical element coupled to an elastic membrane to define an internal cavity; positioning the IOL device within the lens capsule of the subject's eye to substantially center the refractive optical element along an optical axis; and injecting a volume of fluid into the internal cavity of the IOL device sufficient to cause the elastic membrane to contact the posterior portion of the lens capsule which in turn contacts the vitreous body in at least an area at and surrounding the optical axis.
- Other objects, features and advantages of the described preferred embodiments will become apparent to those skilled in the art from the following detailed description. It is to be understood, however, that the detailed description and specific examples, while indicating preferred embodiments of the present invention, are given by way of illustration and not limitation. Many changes and modifications within the scope of the present invention may be made without departing from the spirit thereof; and the invention includes all such modifications.
- Preferred and non-limiting embodiments of the invention may be more readily understood by referring to the accompanying drawings in which:
-
FIGS. 1A and B are sectional views illustrating the certain anatomical features of the human eye with the lens in the unaccommodated and accommodated states, respectively. -
FIGS. 2A , B and C are cut-away perspective, plan and cross-sectional views, respectively, of an embodiment of a refractive optical element coupled to a fluid-filled lens capsule. -
FIGS. 3A and B are plan and side views, respectively, of an embodiment of a refractive optical element and haptic system. -
FIGS. 4A , B and C are cut-away perspective, plan and cross-sectional views, respectively, of an embodiment of a refractive optical element and haptic system ofFIGS. 3A-B coupled to a fluid filled lens capsule. -
FIGS. 5A and B are plan and side views, respectively, of another embodiment of a refractive optical element and haptic system. -
FIGS. 6A , B and C are cut-away perspective, plan and cross-sectional views, respectively, of another embodiment of a refractive optical element and haptic system ofFIGS. 5A-B coupled to a fluid-filled lens capsule. -
FIG. 7 depicts an embodiment of the intraocular lens device implanted in the posterior chamber of a human eye. - Like numerals refer to like parts throughout the several views of the drawings.
- Specific, non-limiting embodiments of the present invention will now be described with reference to the drawings. It should be understood that such embodiments are by way of example only and merely illustrative of but a small number of embodiments within the scope of the present invention. Various changes and modifications obvious to one skilled in the art to which the present invention pertains are deemed to be within the spirit, scope and contemplation of the present invention as further defined in the appended claims.
- As shown in
FIGS. 1A-B , thehuman eye 100 comprises three chambers of fluid: theanterior chamber 112, theposterior chamber 120 and thevitreous chamber 160. Theanterior chamber 112 corresponds generally to the space between thecornea 110 and theiris 114 and theposterior chamber 120 corresponds generally to the space bounded by theiris 114, thelens 130 andzonule fibers 140 connected to the periphery of thelens 130. Theanterior chamber 112 and theposterior chamber 120 contain a fluid known as the aqueous humor, which flows therebetween through an opening that is defined by theiris 114, known as thepupil 116. Light enters theeye 100 through thepupil 116 and travels along a visual axis A-A, striking theretina 170 and thereby produce vision. Theiris 114 regulates the amount of light entering theeye 100 by controlling the size of thepupil 116. - The
vitreous chamber 160 is located between thelens 130 and theretina 170 and contains another fluid, known as the vitreous humor. The vitreous humor is much more viscous than the aqueous humor and is a transparent, colorless, gelatinous mass. Although much of the volume of the vitreous humor is water, it also contains cells, salts, sugars, vitrosin (a type of collagen), a network of collagen type II fibers with the glycosaminoglycan hyaluronic acid, and proteins. The vitreous has a viscosity two to four times that of pure water, giving it a gelatinous consistency. It also has a refractive index of 1.336. - Unlike the aqueous humor contained in the anterior and
posterior chambers - The
lens 130 is a clear, crystalline protein membrane-like structure that is quite elastic, a quality that keeps it under constant tension via the attachedzonules 140 andciliary muscles 150. As a result, thelens 130 naturally tends towards a rounder configuration, a shape it must assume for theeye 100 to focus at a near distance as shown inFIG. 1B . By changing shape, the lens functions to change the focus distance of the eye so that it can focus on objects at various distances, thus allowing a real image of the object of interest to be formed on the retina. - As shown in
FIGS. 1A and 1B , thelens 130 may be characterized as a capsule having two surfaces: ananterior surface 132 and aposterior surface 134. Theanterior surface 132 faces theposterior chamber 120 and theposterior surface 134 faces thevitreous body 160. Theposterior surface 134 contacts thevitreous body 160 in such a manner that fluid movements within thevitreous body 160 are communicated to theposterior surface 134 and may cause the shape of thelens 130 to change. - The eye's natural mechanism of accommodation is reflected by the changes in shape of the
lens 130 and thus the extent to which it refracts light. -
FIG. 1A shows theeye 100 in a relatively unaccommodated state, as may be the case when the eye is focusing at a distance. In an unaccommodated state, theciliary muscles 150 relax, thereby increasing the diameter of its opening and causing the zonules to be pulled away from the visual axis A-A. This, in turn, causes thezonules 140 to radially pull on the periphery of thelens 130 and cause thelens 130 to flatten. As the shape of thelens 130 is flattened, its ability to bend or refract light entering the pupil is reduced. Thus, in an unaccommodated state, thelens 130 has a flatter surface, its diameter e1 along the equatorial axis B-B is lengthened and its thickness d1 along the visual axis A-A is decreased, all relative to the accommodated state (compare e2 and d2 inFIG. 1A ). -
FIG. 1B shows theeye 100 in a relatively accommodated state, as may be the case when the eye is focusing on a nearby object. In an accommodated state, theciliary muscles 150 contract, and the contraction of theciliary muscles 150 causes them to move in an anterior direction. This, in turn, reduces the stress on thezonules 140, thereby lessening the stress exerted by thezonules 140 on thelens 130. Thelens 130 thereupon undergoes elastic recovery and rebounds to a more relaxed and accommodated state, in which thelens 130 has a more convex anterior surface, its diameter e2 along the equatorial axis B-B is decreased and its thickness d2 along the visual axis A-A is increased relative to the unaccommodated state (compare e2 and d1 inFIG. 1A ). AlthoughFIG. 1B depicts the anterior andposterior surfaces lens capsule 130 as having roughly the same radius of curvature, it is believed that during accommodation, the radius of curvature for theanterior surface 132 increases and the radius of curvature of theposterior surface 134 is not significantly changed from its unaccommodated state. - As demonstrated by
FIGS. 1A and 1B , accommodation results from the changes in shape of thelens 130, including the changes in the thickness of the lens capsule 130 (d1 vs. d2), changes in the diameter of the lens capsule 130 (e1 vs. e2) and the changes in the curvature of theanterior surface 132 of thelens capsule 130. While theciliary muscles 150 are known to play a significant role in exerting these changes, it is believed that thevitreous body 160 also plays a significant role, primarily due to the nature of the contact between theposterior surface 134 of thelens 130 and thevitreous body 160, in which theposterior surface 134 responds to and transmits anterior fluid movement in thevitreous body 160 to effectuate changes in shape of thelens 130. -
FIGS. 2A-C illustrate an embodiment of anaccommodating IOL device 200 that may be implanted into thelens capsule 130 of the eye following cataract removal. TheIOL device 200 is shown to comprise anoptical element 210 and aflexible membrane 230 coupled to theoptical element 210. Theoptical element 210 and theflexible membrane 230 together define aninterior cavity 220 which may be filled with fluid. Theoptical element 210 may further optionally comprise aninjection port 212 to permit the injection of the fluid to fill thecavity 220. In a preferred embodiment, theinjection port 212 comprises a one-way valve and is self-sealing. In another preferred embodiment, a separate plug (not shown) may be provided to seal off theinjection port 212. WhileFIGS. 2-7 depict theinjection port 212 as being located within theoptical element 210, it is understood that the placement of theinjection port 212 is not critical, so long as its placement does not impede vision. - The
optical element 210 may be made of plastic, silicone, acrylic, or a combination thereof. In accordance with a preferred embodiment, theoptical element 210 is made of poly(methyl methacrylate) (PMMA), which is a transparent thermoplastic, sometimes called acrylic glass. Because theoptical element 210 is responsible for providing most, if not substantially all, of the refractive power of the IOC device, theoptical element 210 is preferably sufficiently flexible so as to change its curvature in response to the contraction/relaxation of the anterior force that is exerted when the vitreous body bulges in the anterior direction. - In accordance with one embodiment, the
optical element 210 is resiliently biased to a shape that approximates the shape of a natural and unaccommodated lens (seeFIG. 1A ). Theoptical element 210 accordingly increases its degree of curvature in response to the anterior force exerted by the vitreous body and is resiliently biased to a flatter configuration or a decreased degree of curvature, similar to the configuration of the natural lens in the unaccommodated state, in the absence of the anterior force. - In accordance with another embodiment, the
optical element 210 is resiliently biased to a shape that approximates the shape of a natural and accommodated lens (seeFIG. 1B ). Theoptical element 210 accordingly is resiliently biased to a convex configuration similar to that of the natural lens in the accommodated state and assumes a less convex configuration as theciliary muscles 150 relax and the tension of thezonules 140 on thelens capsule 130 increases. - In the embodiment shown in
FIGS. 2A-C , theoptical element 210 has a disk shape of sufficient diameter to engage thezonules 140 of the eye. As this dimension may differ from patient to patient, it is contemplated that theoptical element 210 be provided in a range of sizes to fit a patient's anatomy. In other embodiments, theoptical element 210 may further comprise a separate haptic system (FIGS. 3-6 ) to engage thezonules 140 of the eye. In these embodiments, theoptical element 210 may have a diameter that is significantly smaller than the embodiments in which theoptical element 210 directly engages thezonules 140 of the eye. - Regardless, in engaging the
zonules 140, the IOL device responds to part of the accommodative mechanism of the eye in which theciliary muscles 150 and thezonules 140 cause a bilateral movement of theoptical element 210 along the optical axis to thereby provide part of the accommodating response. - The
accommodating IOL device 200 is additionally configured to allow theoptical clement 210 change its shape in response to the forces exerted upon it by thevitreous body 160. This is achieved by providing a flexibleoptical element 210 and a fluid-filledflexible membrane 230 that is configured to transmit the anterior force of thevitreous body 160 during accommodation to affect the changes in the shape of thelens capsule 130. Preferably, in order to effectuate the transfer of the anterior movements of thevitreous body 160 upon thelens capsule 130, themembrane 230 contacts a substantial area of theposterior surface 134 of thelens capsule 130 and the membrane is sufficiently flexible and substantially devoid of any rigid material that would prevent it from responding to the anterior movements of thevitreous body 160. Thus, theaccommodating IOL device 200 is distinguishable from prior art dual lens IOL devices in maintaining a flexible boundary between thelens capsule 130 and thevitreous body 160. In a particularly preferred embodiment, themembrane 230 is sufficiently thin and deformable so as not to impede the natural flexible boundary between thelens capsule 130 and thevitreous body 160. - Moreover, as explained above, there is a degree of shrinkage experienced by the
lens capsule 130 after cataract surgery which depends on the profile and the dimension of the IOL device that is implanted in thelens capsule 130. As many of the prior art devices have a profile and/or dimension that is substantially different from the original lens capsule 130 (e.g., by having a smaller width d along the optical axis A-A or a smaller diameter along the equatorial axis B-B), a degree of shrinkage is expected which, in turn, affects the extent to which thelens capsule 130 is engaged to thevitreous body 160. In one preferred embodiment, the IOL device minimizes the degree to which this shrinkage occurs by significantly engaging the contours of thelens capsule 130, particularly theposterior surface 134 of thelens capsule 130 via the fluid filledcavity 220 defined by theoptical element 210 andmembrane 230. Themembrane 230 is preferably configured to contact a substantial, if not substantially all, of theposterior surface 134 of thelens capsule 130 at implantation and before any significant shrinkage of thelens capsule 130 has occurred. - As explained above with respect to
FIGS. 1A-B , during accommodation, thevitreous body 160 exerts a force in the anterior direction along the optical axis A-A and pushes thelens capsule 130 in the anterior direction. This, in turn, causes theanterior surface 132 of thelens capsule 130 to become more curved and thus to further refract the light. - Because the
optical clement 210 is responsible for providing most, if not substantially all, of the refractive power of the IOC device, theoptical element 210 is preferably sufficiently flexible so as to change its curvature in response to the contraction/relaxation of the anterior force that is exerted when the vitreous body bulges in the anterior direction. In a preferred embodiment, theoptical element 210 is resiliently biased to a shape that approximates the shape of a natural and unaccommodated lens (seeFIG. 1A ). Theoptical element 210 accordingly increases its degree of curvature in response to the anterior force exerted by the vitreous body and is resiliently biased to a flatter configuration or a decreased degree of curvature, similar to the configuration of the natural lens in the unaccommodated state, in the absence of the anterior force. - The
flexible membrane 230 may be constructed from any biocompatible elastomeric material. In a preferred embodiment, theflexible membrane 230 has an external surface that approximates the posterior surface of the lens capsule adjacent the vitreous body. Theflexible membrane 230 is preferably configured and shaped to contact a substantial, if not the entire, area of the posterior surface of the lens capsule. In a particularly preferred embodiment, this point of contact is at and around the optical axis of the posterior surface. - The
flexible membrane 230 is preferably configured to maximize this transfer of force from the vitreous body to the lens 122. As shown inFIGS. 1A and 1B , theanterior portion 132 of thelens 130 of theunaccommodated eye 100 inFIG. 1A has a lesser degree of curvature (i.e., is flatter) than that of the accommodatedeye 100 ofFIG. 1B . As the vitreous body is believed to exert an anterior force along the optical axis on the lens 122 to effectuate a greater degree of curvature, it is preferable to maximize transfer of force resulting from anterior vitreous movement onto the lens 122. - In accordance with one preferred embodiment, the
flexible membrane 230 may have areas of greater and lesser elasticity so as to maximize the translation of the anterior movements of the vitreous body. For example, as shown inFIG. 2C , theflexible membrane 230 may comprise a central posterior portion 224 (corresponding to an area surrounding the optical axis A-A when theIOL device 200 is implanted) having greater elasticity than the adjacentcircumferential portion 222. Having areas of reduced elasticity in the adjacentcircumferential portion 222 may reduce radial expansion of themembrane 230 and allow the anterior force exerted by thevitreous body 170 to be more effectively translated and applied onto theoptical element 210 by the fluid contained in thecavity 220 to thereby increase the curvature of theoptical element 210. - In accordance with another preferred embodiment, the
IOL device 200 may be configured to resiliently assume a shape having a width d3 that is substantially equal to the width thelens capsule 130 accommodated eye (see d2 ofFIG. 1B ) when it is implanted in the patient's eye. This may be achieved by constructing theIOL device 200 with resilient materials having some degree of shape memory and also by filling thecavity 220 with a volume of fluid sufficient to expand theflexible membrane 230 to the desired width, d3. - In accordance with a further preferred embodiment, the
IOL device 200 comprises a single lens. The incorporation of additional lenses in the IOL device would likely interfere with the ability of the lens to deform (i.e., increase its curvature and provide additional diopters of power) to anterior vitreous movement. - The flexible membrane may preferably be made from a polyvinylidene fluoride (PDVF) material. PDVF is believed to allow for the transmission of lasers energy without, itself, becoming degraded. Optionally, a reinforced
portion 234 of theflexible membrane 230 may optionally be provided to resist degradation upon the application of lasers of various wavelengths. In a preferred embodiment, the reinforcedsection 234 is positioned at an area on themembrane 230 corresponding to the optical axis A-A when theIOL device 200 is implanted in the subject's eye. Normally, after cataract surgery, a few of the residual epithelial cells in the lens capsule may migrate to a posterior surface of the bag resulting in various degrees of fibrosis which, in turn, may lead to undesired posterior capsule opacification (PCO). PCO is undesired, particularly at the optical path, and is typically treated by the application of laser pulses (e.g., YAG laser capsulotomy) to burn away the fibrotic membrane. Thus, a reinforcedportion 234 may be provided on themembrane 230 as a protective mechanism against the potentially degradative effects of laser treatment on themembrane 230. In a preferred embodiment, the reinforcedportion 234 remains flexible and is sized to correspond to the central area at and surrounding the optical axis A-A. - Once the IOL device is implanted in the lens capsule of the patient, a volume of fluid is injected into the
cavity 220 via aninjection port 212. In a preferred embodiment, the fluid is an aqueous solution of saline or hyaluronic acid and does not provide a significant, or any, contribution to the refractive power of the IOC device. Thus, the function of the fluid is primarily as a vehicle to transfer force resulting from the movement of thevitreous body 150 onto theoptical element 210 to provide the accommodation. In a preferred embodiment, the fluid has a viscosity that is substantially the same as the vitreous humor. In another preferred embodiment, the fluid has a refractive index that is substantially the same as the aqueous humor or the vitreous humor. - The IOL device is distinguishable from prior art teachings in which the lens capsule is with various types of polymers, which are injected in liquid form and set with UV or other methods of polymerization. These attempts have been met with much difficulty as it is often difficult to control the refractive power provided by the polymerized polymers. Here, the refractive power is provided substantially, if not entirely, by the
optical element 210 and the fluid that is contained within thecavity 220 does not contribute significantly, if at all, to providing the refractive power of the IOL device. Moreover, unlike the prior art polymers used to fill the lens capsule, the fluid is a relatively inert or biocompatible material, such as saline, or it alternatively contains a high molecular weight compound, such as hyaluronic acid, which does not readily leak from theIOL device 200. - The precise volume of fluid injected into the
cavity 220 may differ based on the subject's anatomy, among other factors. The volume of fluid injected into thecavity 220 is not critical so long as it is sufficient to expand themembrane 230 such that the posterior portion of themembrane 230 substantially contacts the posterior portion of the lens capsule and engages the vitreous body of the subject's eye. As explained above, in one preferred embodiment, a volume of fluid is injected into thecavity 220 so as to provide a width d3 of the IOL device along the optical axis A-A substantially approximating the lens width d2 of the accommodatedeye 100. In another preferred embodiment, a volume of fluid is injected into thecavity 220 so as to provide a width d3 of the IOL device along the optical axis AA substantially approximating the width d1 of theunaccommodated eye 100. - A haptic system may be incorporated with the IOL device to position the
optical element 210 at the optical axis A-A when implanted in the subject's eye. As it is preferable to center theoptical element 210 relative to the optical axis A-A, the haptic system preferably comprises a plurality of haptic members extending radially from the IOL device and engaging thezonules 140 surrounding thelens capsule 130 of the eye. -
FIGS. 3A-B depict anoptical element 210 comprising a pair ofspring haptics 350 coupled to opposing sides of theoptical element 210. As further shown inFIGS. 4A-C , aflexible membrane 230 may be coupled to theoptical element 210/haptic 350 assembly along the periphery of theoptical element 210. A seal is effectuated between theflexible membrane 230 and the periphery of theoptical element 210 by laser welding and any other means known to those of skill in the art. - In another embodiment, the
optical element 210 may be contained within aflexible membrane 230 that fully encloses theoptical element 210. In accordance with this element,flexible membrane 230 has a bag or balloon-like configuration and thespring haptics 350 may be attached either (1) to theoptical element 210 itself and protrude from a sealed opening in theflexible membrane 230 or (2) to theflexible membrane 230. AlthoughFIGS. 3-4 depict a pair ofspring haptics 350 extending radially from theoptical element 210, it is understood that any number ofspring haptics 350 may be provided so long asoptical element 210 is centered about the optical axis A-A when the IOL device is implanted in the eye. -
FIGS. 5A-B depict anoptical element 210 comprising a pair of plate haptics 450 coupled to opposing sides of theoptical element 210. The plate haptics 450 comprise a pair of plate members each comprising afirst end 452 attached to theoptical element 210 and asecond end 456 configured to engage thezonules 140 of theeye 100 when implanted in thelens capsule 130. A hinge 464 is disposed between the first and second ends 452, 456, to allow lateral movement of theoptical element 210 in the anterior and posterior directions as theciliary muscles 150 relax and contract, respectively. As further shown inFIGS. 6A-C , aflexible membrane 230 may be coupled to theoptical element 210/haptic 450 assembly along the periphery of theoptical element 210. - In another embodiment, the
optical element 210 may be contained within aflexible membrane 230 that fully encloses theoptical element 210. In accordance with this element, thespring haptics 450 may be attached either (1) to theoptical element 210 itself and protrude from a sealed opening in theflexible membrane 230 or (2) to theflexible membrane 230. AlthoughFIGS. 5-6 depict a pair ofplate haptics 450 extending radially from theoptical element 210, it is understood that any number of plate haptics 450 may be provided so long asoptical element 210 is centered about the optical axis A-A when the IOL device is implanted in the eye. -
FIG. 7 depicts an embodiment of the accommodating IOL device implanted in thelens capsule 130 of the eye in an accommodated state. Because both theoptical element 210 and themembrane 230 of theIOL device 200 is sufficiently flexible, it may be folded or rolled compactly prior to implantation, thereby requiring only a small incision of a few millimeters for insertion into the eye. As shown inFIG. 7 , after the IOL device is implanted and thecavity 220 is filled with fluid, the IOL device is divided roughly in two: theanterior lens portion 210 facing theposterior capsule 120 and theposterior membrane portion 230 facing thevitreous body 160. The width d3 of the IOL device is resiliently biased to having a width that is roughly equal to the width of the natural lens capsule when it is in an accommodated state (see d2 ofFIG. 1B ). Theposterior membrane portion 230 has an area of contact that approximates the surface area of theposterior portion 134 of the lens capsule 130 (SeeFIGS. 1A-B ). Two ormore haptics 550 are shown to protrude from the IOL device to substantially center theanterior lens portion 210 along the optical axis A-A. - The accommodated IOL device shown in
FIG. 7 is implanted in the lens capsule of a subject's eye by introducing an IOL device in the lens capsule of the subject's eye through a small incision in the subject's eye, wherein the IOL device comprises a refractiveoptical element 210 coupled to anelastic membrane 230 to define aninternal cavity 220. The IOL device is then positioned within thelens capsule 130 of the subject's eye to substantially center the refractiveoptical element 210 along an optical axis A-A. A volume of fluid is then injected into theinternal cavity 220 of the IOL device sufficient to cause theelastic membrane 230 to contact the posterior portion of the lens capsule which, in turn, contacts the vitreous body in at least an area at and surrounding the optical axis A-A. In a preferred embodiment, the volume of fluid injected into theinternal cavity 220 is sufficient to produce a width d3 of the IOL device along the optical axis A-A that is substantially equal to the width of a natural lens capsule in an accommodated state. - The invention described and claimed herein is not to be limited in scope by the specific preferred embodiments disclosed herein, as these embodiments are intended as illustrations of several aspects of the invention. Indeed, various modifications of the invention in addition to those shown and described herein will become apparent to those skilled in the art from the foregoing description. Such modifications are also intended to fall within the scope of the appended claims.
Claims (20)
1. An accommodating intraocular lens (IOL) device adapted for implantation in the lens capsule of a subject's eye, the IOL device comprising:
an anterior portion comprising a refractive optical element;
an elastic posterior portion; and
an enclosed cavity defined between the anterior and posterior portions;
wherein the cavity is configured to contain a volume of fluid to space apart the anterior and posterior portions;
wherein the posterior portion is configured to contact a posterior area of the lens capsule adjoining the vitreous body at least in the area at and surrounding the optical axis when the IOL device is implanted in the eye and the cavity contains the fluid; and
wherein the posterior portion actuates in response to an anterior force exerted by the vitreous body, causing the fluid to exert a deforming or displacing force on the refractive optical element.
2. The accommodating IOL device of claim 1 , wherein the refractive optical element increases its degree of curvature in response to the anterior force and decreases its degree of curvature in the absence of the anterior force.
3. The accommodating JUL device of claim 2 , wherein the refractive optical element is resiliently biased to having a degree of curvature that is substantially equal to the degree of curvature of the anterior portion of the subject's natural lens capsule.
4. The accommodating IOL device of claim 1 , wherein the IOL device is biased to a configuration having a width that is substantially equal to the width of the unaccommdated natural lens capsule along the optical axis.
5. The accommodating IOL device of claim 1 , wherein the IOL device has an equatorial diameter that is substantially equal to the equatorial diameter of the subject's natural lens capsule in the unaccommodated state.
6. The accommodating IOL device of claim 1 , wherein the anterior portion is dimensioned to engage the zonules when the IOL device is implanted in the subject's eye.
7. The accommodating IOL device of claim 1 , further comprising a haptic system coupled to the anterior portion.
8. The accommodating IOL device of claim 7 , wherein the haptic system is configured to substantially center the refractive optical element in the path of the optical axis when implanted in the subject's eye.
9. The accommodating IOL device of claim 8 , wherein the haptic system is configured to bilaterally displace the refractive optical element along the optical axis in response to the contraction and relaxation of the ciliary muscles when the IOL device is implanted in the subject's eye.
10. The accommodating IOL device of claim 1 , wherein the volume of fluid contained in the cavity is sufficient to space apart the anterior and posterior portions at a distance d3 along the optical axis that is substantially equal to the width d2 of the subject's natural lens capsule along the optical axis in the unaccommodated state.
11. An accommodating intraocular lens (IOL) device adapted for implantation in the lens capsule of a subject's eye, the IOL device comprising:
an anterior refractive optical element; and
a membrane comprising a posterior surface, the membrane coupled to the anterior optical element and defining an enclosed cavity configured to contain a volume of fluid;
wherein the posterior portion is configured to contact a posterior area of the lens capsule adjoining the vitreous body at least in an area at and surrounding the optical axis when the IOL device is implanted in the eye and the cavity contains the fluid; and
wherein the fluid deforms the anterior refractive optical element in response to an anterior force exerted on the posterior surface by the vitreous body.
12. The accommodating IOL of claim 11 , wherein the anterior optical element further comprises a self-sealing valve to permit the injection of the fluid.
13. The accommodating IOL device of claim 11 , wherein the fluid is viscoelastic.
14. The accommodating IOL device of claim 11 , wherein the fluid is an aqueous solution of saline or hyaluronic acid.
15. The accommodating IOL device of claim 11 , wherein the fluid has substantially the same viscosity as the vitreous humor.
16. The accommodating IOL device of claim 11 , wherein the fluid has substantially the same refractive index as the aqueous humor or the vitreous humor.
17. The accommodating IOL device of claim 11 , wherein the membrane is coupled to the anterior refractive optical element about its periphery.
18. The accommodating IOL device of claim 11 , wherein the anterior refractive optical element is contained within the enclosed cavity of the membrane.
19. The accommodating IOL device of claim 11 , wherein the posterior portion further comprises a reinforced portion.
20. A method for implanting an accommodating intraocular accommodating lens (IOUL) device in a subject's eye comprising:
introducing an IOL device in the lens capsule of the subject's eye through an incision in the subject's eye, wherein the IOL device comprises a refractive optical element coupled to an elastic membrane to define an internal cavity;
positioning the IOL device within the lens capsule of the subject's eye to substantially center the refractive optical element along an optical axis; and
injecting a volume of fluid into the internal cavity of the IOL device sufficient to cause the elastic membrane to contact a posterior area of the lens capsule adjoining the vitreous body in at least an area at and surrounding the optical axis.
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Families Citing this family (22)
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WO2021034187A1 (en) | 2019-08-19 | 2021-02-25 | Akkolens International B.V. | Accommodative intraocular lens combination with independent fixed and variable power lens sections |
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NL2027301B1 (en) | 2020-01-13 | 2021-10-26 | Akkolens Int B V | Mechanical means for accommodative intraocular lens |
NL2028038B1 (en) | 2020-05-11 | 2022-07-04 | Akkolens Int B V | Method to connect and distance hydrophilic intraocular lens elements |
DE102021110782B3 (en) * | 2021-04-27 | 2022-03-31 | Carl Zeiss Meditec Ag | Method of making an accommodative intraocular lens |
US11357620B1 (en) | 2021-09-10 | 2022-06-14 | California LASIK & Eye, Inc. | Exchangeable optics and therapeutics |
KR20230172951A (en) * | 2022-06-16 | 2023-12-26 | 가톨릭대학교 산학협력단 | An anterior segment stabilization device |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4932966A (en) * | 1988-08-15 | 1990-06-12 | Storz Instrument Company | Accommodating intraocular lens |
US20060212116A1 (en) * | 2002-10-25 | 2006-09-21 | Advanced Medical Optics, Inc. | Capsular intraocular lens implant having a refractive liquid therein |
US20090149952A1 (en) * | 2003-02-03 | 2009-06-11 | Shadduck John H | Intraocular Lenses and Business Methods |
US20120245683A1 (en) * | 2009-12-04 | 2012-09-27 | Acufocus, Inc. | Corneal implant for refractive correction |
Family Cites Families (312)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4032502A (en) | 1975-10-10 | 1977-06-28 | Dow Corning Corporation | Organosiloxane compositions for liquid injection |
US4373218A (en) | 1980-11-17 | 1983-02-15 | Schachar Ronald A | Variable power intraocular lens and method of implanting into the posterior chamber |
US4512040A (en) | 1982-06-09 | 1985-04-23 | Mcclure Hubert L | Bifocal intraocular lens |
US4720286A (en) | 1984-07-20 | 1988-01-19 | Bailey Kelvin E | Multifocus intraocular lens |
US4585457A (en) | 1985-05-16 | 1986-04-29 | Kalb Irvin M | Inflatable intraocular lens |
US4676791A (en) | 1985-08-01 | 1987-06-30 | Surgidev Corporation | Intraocular lens and method for making same |
US4731078A (en) | 1985-08-21 | 1988-03-15 | Kingston Technologies Limited Partnership | Intraocular lens |
US5059668A (en) | 1986-01-20 | 1991-10-22 | Shin-Etsu Chemical Co., Ltd. | Fluorosilicone rubber composition |
US5236970A (en) | 1987-02-05 | 1993-08-17 | Allergan, Inc. | Optically clear reinforced silicone elastomers of high optical refractive index and improved mechanical properties for use in intraocular lenses |
US4842601A (en) | 1987-05-18 | 1989-06-27 | Smith S Gregory | Accommodating intraocular lens and method of implanting and using same |
US5074876A (en) | 1987-12-04 | 1991-12-24 | Kelman Charles D | Two piece intraocular lens |
US4888012A (en) | 1988-01-14 | 1989-12-19 | Gerald Horn | Intraocular lens assemblies |
DE68920167T2 (en) | 1988-02-12 | 1995-06-29 | Menicon Co Ltd | Method of making an intraocular lens balloon. |
US4822360A (en) | 1988-03-16 | 1989-04-18 | University Of Utah | Inflatable, intraocular lens and method of implanting the lens in the capsule of an eye |
US4882368A (en) | 1988-09-26 | 1989-11-21 | Dow Corning Corporation | Low compression set fluorosilicone rubber |
US4892543A (en) * | 1989-02-02 | 1990-01-09 | Turley Dana F | Intraocular lens providing accomodation |
US5227447A (en) | 1989-12-07 | 1993-07-13 | Shin-Etsu Chemical Co., Ltd. | Preparation of high molecular weight organopolysiloxane |
US5152788A (en) | 1989-12-27 | 1992-10-06 | Minnesota Mining And Manufacturing Company | Multifocal diffractive ophthalmic lens and method of manufacture |
JPH03202102A (en) | 1989-12-28 | 1991-09-03 | Toray Dow Corning Silicone Co Ltd | Method for reducing amount of siloxane oligomer in organopolysiloxane molded product |
US6197059B1 (en) | 1990-04-27 | 2001-03-06 | Medevec Licensing, B.V. | Accomodating intraocular lens |
US5217491A (en) | 1990-12-27 | 1993-06-08 | American Cyanamid Company | Composite intraocular lens |
WO1992017132A1 (en) | 1991-03-25 | 1992-10-15 | Albert Daxer | Artificial eye-lens |
FR2681524B1 (en) | 1991-09-25 | 1997-04-04 | Mnao | CRYSTALLINE IMPLANT. |
US5171773A (en) | 1991-11-13 | 1992-12-15 | Dow Corning Corporation | High strength fluorosilicone rubber |
US5275623A (en) * | 1991-11-18 | 1994-01-04 | Faezeh Sarfarazi | Elliptical accommodative intraocular lens for small incision surgery |
US5278258A (en) | 1992-05-18 | 1994-01-11 | Allergan, Inc. | Cross-linked silicone polymers, fast curing silicone precursor compositions, and injectable intraocular lenses |
US5312860A (en) | 1992-09-10 | 1994-05-17 | Shin-Etsu Chemical Co., Ltd. | Heat-curable silicone rubber composition and cured product thereof |
US5264522A (en) | 1992-09-10 | 1993-11-23 | Shin-Etsu Chemical Co., Ltd. | Heat-curable fluorosilicone rubber composition and cured product thereof |
US5443506A (en) | 1992-11-18 | 1995-08-22 | Garabet; Antoine L. | Lens with variable optical properties |
US5336487A (en) | 1993-03-05 | 1994-08-09 | Refojo Miguel F | Method of treating eye disorders with silicon/fluorosilicone copolymer oil |
US5447987A (en) | 1993-12-24 | 1995-09-05 | Shin-Etsu Chemical Co., Ltd. | Organopolysiloxane compositions |
DE69511067T2 (en) | 1994-01-31 | 1999-12-09 | Bausch & Lomb | METHOD FOR TREATING CONTACT LENSES WITH SUPERCRITICAL FLUIDUM |
US5489302A (en) * | 1994-05-24 | 1996-02-06 | Skottun; Bernt C. | Accommodating intraocular lens |
AU3002495A (en) | 1994-06-30 | 1996-01-25 | Minnesota Mining And Manufacturing Company | Cure-indicating molding and coating composition |
US5607472A (en) | 1995-05-09 | 1997-03-04 | Emory University | Intraocular lens for restoring accommodation and allows adjustment of optical power |
US5774274A (en) | 1995-05-12 | 1998-06-30 | Schachar; Ronald A. | Variable focus lens by small changes of the equatorial lens diameter |
JPH09150002A (en) | 1995-11-29 | 1997-06-10 | Shin Etsu Chem Co Ltd | Refining method for silicone oil |
US5665794A (en) | 1996-05-20 | 1997-09-09 | Dow Corning Corporation | Method for controlling cure initiation and curing times of platinum group metal curing fluorosilicone compositions |
DE19654488A1 (en) | 1996-12-27 | 1998-07-02 | Sueddeutsche Kalkstickstoff | Process for the fractionation of viscous silicones |
US5854310A (en) | 1997-07-21 | 1998-12-29 | Dow Corning Corporation | Curable fluorosilicone composition having improved lubricity |
US6361561B1 (en) | 1998-10-13 | 2002-03-26 | Pharmacia & Upjohn Ab | Injectable intraocular lens |
US6197057B1 (en) | 1998-10-27 | 2001-03-06 | Gholam A. Peyman | Lens conversion system for teledioptic or difractive configurations |
US6117171A (en) | 1998-12-23 | 2000-09-12 | Skottun; Bernt Christian | Encapsulated accommodating intraocular lens |
US7662179B2 (en) | 1999-04-09 | 2010-02-16 | Sarfarazi Faezeh M | Haptics for accommodative intraocular lens system |
US20060238702A1 (en) | 1999-04-30 | 2006-10-26 | Advanced Medical Optics, Inc. | Ophthalmic lens combinations |
US20030060881A1 (en) | 1999-04-30 | 2003-03-27 | Advanced Medical Optics, Inc. | Intraocular lens combinations |
US6299641B1 (en) * | 1999-09-10 | 2001-10-09 | Randall Woods | Intraocular lens implant having eye accommodating capabilities |
US6767363B1 (en) | 1999-11-05 | 2004-07-27 | Bausch & Lomb Surgical, Inc. | Accommodating positive and negative intraocular lens system |
US6551354B1 (en) | 2000-03-09 | 2003-04-22 | Advanced Medical Optics, Inc. | Accommodating intraocular lens |
US6613343B2 (en) | 2000-04-12 | 2003-09-02 | Pharmacia Groningen Bv | Injectable intraocular accommodating lens |
US20050251254A1 (en) | 2000-06-02 | 2005-11-10 | Brady Daniel G | Method of implanting accommodating intraocular lenses |
US6730123B1 (en) | 2000-06-22 | 2004-05-04 | Proteus Vision, Llc | Adjustable intraocular lens |
US7137994B2 (en) | 2000-07-11 | 2006-11-21 | John Hopkins University | Injectable bag intraocular lens system, inserting device for use therewith, method for inserting an injectable bag intraocular lens within a human eye, methods for treating aphakia and system kits |
US6846326B2 (en) | 2001-01-25 | 2005-01-25 | Visiogen, Inc. | Connection geometry for intraocular lens system |
US8062361B2 (en) | 2001-01-25 | 2011-11-22 | Visiogen, Inc. | Accommodating intraocular lens system with aberration-enhanced performance |
US7780729B2 (en) | 2004-04-16 | 2010-08-24 | Visiogen, Inc. | Intraocular lens |
US20030078657A1 (en) | 2001-01-25 | 2003-04-24 | Gholam-Reza Zadno-Azizi | Materials for use in accommodating intraocular lens system |
US20040148023A1 (en) | 2001-02-15 | 2004-07-29 | Shu Stephen K. | High gain wide range accommodating intraocular lens for implant into the capsular bag |
US20020120329A1 (en) | 2001-02-28 | 2002-08-29 | Allergan Sales, Inc. | Moveable intraocular lenses and combinations of intraocular lenses |
US7229475B2 (en) | 2001-06-11 | 2007-06-12 | Vision Solutions Technologies, Inc. | Multi-focal intraocular lens, and methods for making and using same |
US20030105522A1 (en) | 2001-06-11 | 2003-06-05 | Glazier Alan N. | Multi-focal intraocular lens |
US6855164B2 (en) | 2001-06-11 | 2005-02-15 | Vision Solutions Technologies, Llc | Multi-focal intraocular lens, and methods for making and using same |
IL145015A0 (en) | 2001-08-21 | 2002-06-30 | Nun Yehoshua Ben | Accommodating lens |
US20030060878A1 (en) * | 2001-08-31 | 2003-03-27 | Shadduck John H. | Intraocular lens system and method for power adjustment |
US7097660B2 (en) | 2001-12-10 | 2006-08-29 | Valdemar Portney | Accommodating intraocular lens |
JP3985133B2 (en) | 2001-12-21 | 2007-10-03 | 信越化学工業株式会社 | Thixo fluorine-containing curable composition and encapsulated material using the same |
US10045844B2 (en) | 2002-02-02 | 2018-08-14 | Powervision, Inc. | Post-implant accommodating lens modification |
US8048155B2 (en) | 2002-02-02 | 2011-11-01 | Powervision, Inc. | Intraocular implant devices |
US7261737B2 (en) | 2002-12-12 | 2007-08-28 | Powervision, Inc. | Accommodating intraocular lens system and method |
US20050021139A1 (en) | 2003-02-03 | 2005-01-27 | Shadduck John H. | Ophthalmic devices, methods of use and methods of fabrication |
US6860601B2 (en) * | 2002-02-06 | 2005-03-01 | John H. Shadduck | Adaptive optic lens system and method of use |
US20030181749A1 (en) | 2002-03-21 | 2003-09-25 | Kunzler Jay F. | Supercritical fluid extraction of vitreoretinal silicone tamponades |
US6695881B2 (en) | 2002-04-29 | 2004-02-24 | Alcon, Inc. | Accommodative intraocular lens |
CA2493673C (en) * | 2002-07-25 | 2012-04-10 | Visiogen, Inc. | Method of preparing an intraocular lens for implantation |
AU2003281766A1 (en) | 2002-07-29 | 2004-02-16 | Yosef Gross | Tensioning intraocular lens assembly |
AU2002950469A0 (en) | 2002-07-30 | 2002-09-12 | Commonwealth Scientific And Industrial Research Organisation | Improved biomedical compositions |
US6966649B2 (en) | 2002-08-12 | 2005-11-22 | John H Shadduck | Adaptive optic lens system and method of use |
FR2844703B1 (en) | 2002-09-25 | 2005-07-08 | Alain Nicolas Gilg | INTRAOCULAR DEVICE FOR RESTORING THE ACCOMMODATION OF THE EYE WITH PRESBYOPIA |
US7125422B2 (en) * | 2002-10-25 | 2006-10-24 | Quest Vision Technology, Inc. | Accommodating intraocular lens implant |
JP4473217B2 (en) | 2002-10-25 | 2010-06-02 | クエスト ヴィジョン テクノロジー, アイエヌシー. | Implantable artificial lens |
US6836374B2 (en) | 2002-11-20 | 2004-12-28 | Powervision, Inc. | Lens system and methods for power adjustment |
US20040111152A1 (en) | 2002-12-10 | 2004-06-10 | Kelman Charles David | Accommodating multifocal intraocular lens |
EP2559405A3 (en) | 2002-12-12 | 2013-06-26 | PowerVision, Inc. | Accommodating intraocular lens system |
US10835373B2 (en) | 2002-12-12 | 2020-11-17 | Alcon Inc. | Accommodating intraocular lenses and methods of use |
US7247168B2 (en) | 2002-12-12 | 2007-07-24 | Powervision, Inc. | Accommodating intraocular lens system and method |
US8328869B2 (en) | 2002-12-12 | 2012-12-11 | Powervision, Inc. | Accommodating intraocular lenses and methods of use |
US8361145B2 (en) | 2002-12-12 | 2013-01-29 | Powervision, Inc. | Accommodating intraocular lens system having circumferential haptic support and method |
US7637947B2 (en) | 2002-12-12 | 2009-12-29 | Powervision, Inc. | Accommodating intraocular lens system having spherical aberration compensation and method |
CA2508143A1 (en) | 2002-12-12 | 2004-06-24 | Powervision, Inc. | Lens system for power adjustment using micropumps |
US7217288B2 (en) | 2002-12-12 | 2007-05-15 | Powervision, Inc. | Accommodating intraocular lens having peripherally actuated deflectable surface and method |
US6616691B1 (en) | 2003-01-10 | 2003-09-09 | Alcon, Inc. | Accommodative intraocular lens |
US7238201B2 (en) | 2003-02-13 | 2007-07-03 | Visiogen, Inc. | Accommodating intraocular lens system with enhanced range of motion |
AU2004219674A1 (en) | 2003-03-06 | 2004-09-23 | Powervision, Inc. | Adaptive optic lens and method of making |
US7223288B2 (en) | 2003-05-21 | 2007-05-29 | Alcon, Inc. | Accommodative intraocular lens |
US20040249455A1 (en) | 2003-06-09 | 2004-12-09 | Tran Son Trung | Accommodative intraocular lens system |
GB0319408D0 (en) | 2003-08-19 | 2003-09-17 | Chawdhary Satish | Intraocular device |
DE10346024B4 (en) | 2003-08-26 | 2019-01-17 | Carl Zeiss Meditec Ag | Ciliary muscle-operated, accommodative lens implant |
DE20316792U1 (en) | 2003-08-26 | 2005-01-05 | Schedler, Markus | Ciliary muscle-operated, accommodative lens implant |
US20050107873A1 (en) | 2003-11-18 | 2005-05-19 | Medennium, Inc. | Accommodative intraocular lens and method of implantation |
US20050137703A1 (en) | 2003-12-05 | 2005-06-23 | Vanderbilt University | Accommodative intraocular lens |
US20050131535A1 (en) | 2003-12-15 | 2005-06-16 | Randall Woods | Intraocular lens implant having posterior bendable optic |
NL1025622C2 (en) | 2004-03-03 | 2005-09-07 | Accolens Internat B V | Two optical elements with variable optical power together forming a lens for use as an intraocular lens. |
US7150760B2 (en) | 2004-03-22 | 2006-12-19 | Alcon, Inc. | Accommodative intraocular lens system |
AU2005267561A1 (en) | 2004-03-31 | 2006-02-02 | The Regents Of The University Of California | Fluidic adaptive lens |
US20110118834A1 (en) | 2004-03-31 | 2011-05-19 | Yuhwa Lo | Fluidic intraocular lens systems and methods |
US7453646B2 (en) | 2004-03-31 | 2008-11-18 | The Regents Of The University Of California | Fluidic adaptive lens systems and methods |
US8018658B2 (en) | 2004-03-31 | 2011-09-13 | The Regents Of The Univeristy Of California | Fluidic adaptive lens systems and methods |
IL161706A0 (en) | 2004-04-29 | 2004-09-27 | Nulens Ltd | Intraocular lens fixation device |
US9005282B2 (en) | 2004-04-30 | 2015-04-14 | Calhoun Vision, Inc. | Intraocular lens system with injectable accommodation material |
US9713527B2 (en) | 2004-04-30 | 2017-07-25 | Rxsight, Inc. | Multilens intraocular lens system with injectable accommodation material |
US7063723B2 (en) | 2004-07-23 | 2006-06-20 | Sun Ran | Intraocular lens with an accommodating capability |
US20100057095A1 (en) * | 2004-08-18 | 2010-03-04 | Leonid Orbachevsky | Method of Refraction Surgery of the Eye and a Tool for Implanting Intraocular Refractive Lens |
US7806929B2 (en) | 2004-08-27 | 2010-10-05 | Brown David C | Intracapsular pseudophakic device |
US20060069178A1 (en) | 2004-09-24 | 2006-03-30 | Bausch & Lomb Incorporated | Method for polymerizing ophthalmic devices |
AU2005293142B2 (en) | 2004-10-13 | 2010-09-02 | Nulens Ltd | Accommodating intraocular lens (AIOL), and AIOL assemblies including same |
US9872763B2 (en) | 2004-10-22 | 2018-01-23 | Powervision, Inc. | Accommodating intraocular lenses |
SE0403091D0 (en) | 2004-12-20 | 2004-12-20 | Amo Groningen Bv | New composition for injectable ophthalmic lenses |
SE0403093D0 (en) | 2004-12-20 | 2004-12-20 | Amo Groningen Bv | New polysiloxanes; synthesis and use thereof |
US20120071972A1 (en) | 2004-12-29 | 2012-03-22 | Iris Ginron Zhao | Multiphase eyecare |
US8216306B2 (en) | 2005-01-13 | 2012-07-10 | Minas Theodore Coroneo | Ocular auto-focusing lenses |
NL1029041C1 (en) | 2005-03-09 | 2006-09-12 | Akkolens Int Bv | Improved construction of an intraocular artificial lens |
CA2601351A1 (en) | 2005-03-30 | 2006-10-05 | Nulens Ltd | Accommodating intraocular lens (aiol) assemblies, and discrete components therfor |
US20060241752A1 (en) | 2005-04-20 | 2006-10-26 | Israel Henry M | Accommodating multiple lens assembly |
JP4476162B2 (en) * | 2005-04-28 | 2010-06-09 | 株式会社ニデック | Intraocular lens |
EP1890652B1 (en) | 2005-05-13 | 2017-08-02 | Akkolens International B.V. | Intra-ocular artificial lens for iris-driven accommodation |
GB0510196D0 (en) | 2005-05-19 | 2005-06-22 | Univ Liverpool | Composition for treatment of a detached retina and method of production thereof |
DE502005007656D1 (en) | 2005-05-27 | 2009-08-20 | Wavelight Laser Technologie Ag | intraocular lens |
GB2427484A (en) | 2005-06-21 | 2006-12-27 | Global Bionic Optics Pty Ltd | Variable power fluid lens with flexible wall |
US7591849B2 (en) | 2005-07-01 | 2009-09-22 | Bausch & Lomb Incorpoted | Multi-component accommodative intraocular lens with compressible haptic |
US20070016293A1 (en) | 2005-07-18 | 2007-01-18 | Alcon, Inc. | Accommodative intraocular lens system |
US8038711B2 (en) * | 2005-07-19 | 2011-10-18 | Clarke Gerald P | Accommodating intraocular lens and methods of use |
US20070032868A1 (en) | 2005-08-08 | 2007-02-08 | Randall Woods | Capsular shape-restoring device |
US7316713B2 (en) | 2005-08-29 | 2008-01-08 | Alcon, Inc. | Accommodative intraocular lens system |
US9629712B2 (en) | 2005-09-01 | 2017-04-25 | Donald C. Stenger | Accommodating intraocular lens |
US8034107B2 (en) | 2005-09-01 | 2011-10-11 | Stenger Donald C | Accommodating intraocular lens |
JP4927371B2 (en) | 2005-09-28 | 2012-05-09 | 興和株式会社 | Intraocular lens |
US9636213B2 (en) | 2005-09-30 | 2017-05-02 | Abbott Medical Optics Inc. | Deformable intraocular lenses and lens systems |
US20070088433A1 (en) | 2005-10-17 | 2007-04-19 | Powervision | Accommodating intraocular lens system utilizing direct force transfer from zonules and method of use |
US8603164B2 (en) | 2005-10-27 | 2013-12-10 | Gholam A. Peyman | Adjustable fluidic telescope |
US20070118216A1 (en) | 2005-11-21 | 2007-05-24 | Joel Pynson | Accommodative intraocular lens |
US7985253B2 (en) * | 2005-12-07 | 2011-07-26 | C&C Vision International Limited | Hydrolic accommodating intraocular lens |
US20070129800A1 (en) | 2005-12-07 | 2007-06-07 | C&C Vision International Limited | Hydrolic accommodating intraocular lens |
US7981155B2 (en) * | 2005-12-07 | 2011-07-19 | C&C Vision International Limited | Hydrolic accommodating intraocular lens |
EP1969397B1 (en) | 2005-12-14 | 2017-11-08 | Novartis AG | Method for preparing silicone hydrogels |
US20070260308A1 (en) | 2006-05-02 | 2007-11-08 | Alcon, Inc. | Accommodative intraocular lens system |
EP2023857A2 (en) | 2006-05-08 | 2009-02-18 | Bausch & Lomb Incorporated | Accommodative intraocular lens having defined axial compression characteristics |
US20080046077A1 (en) | 2006-08-15 | 2008-02-21 | C&C Vision International Limited | Multiocular Intraocular Lens Systems |
US20100004742A1 (en) | 2006-08-15 | 2010-01-07 | C7C Vision International Limited | Multiocular Intraocular Lens System |
US20080051886A1 (en) | 2006-08-24 | 2008-02-28 | Lin J T | Method and device for vision correction via dual-optics accommodating intraocular lens |
GB0618262D0 (en) * | 2006-09-16 | 2006-10-25 | Khoury Elie | Accommodative intra-ocular lens |
EP1932492B1 (en) | 2006-12-13 | 2011-09-14 | Akkolens International B.V. | Accommodating intraocular lens with variable correction |
AU2007338100B2 (en) | 2006-12-22 | 2014-01-30 | Amo Groningen Bv | Accommodating intraocular lens, lens system and frame therefor |
WO2008079671A1 (en) | 2006-12-22 | 2008-07-03 | Bausch & Lomb Incorporated | Multi-element accommodative intraocular lens |
JP5207626B2 (en) | 2006-12-26 | 2013-06-12 | 東レ・ダウコーニング株式会社 | Heat curable silicone rubber composition for rubber laminate comprising silicone rubber layer and different rubber layer, rubber laminate and method for producing the same |
US7713299B2 (en) | 2006-12-29 | 2010-05-11 | Abbott Medical Optics Inc. | Haptic for accommodating intraocular lens |
EP2097045B1 (en) | 2006-12-29 | 2013-11-20 | Abbott Medical Optics Inc. | Multifocal accommodating intraocular lens |
US8608799B2 (en) | 2007-01-24 | 2013-12-17 | Tekia, Inc. | Umbrella-shaped accommodating artificial ocular lens (AAOL) device |
US8034106B2 (en) * | 2007-02-02 | 2011-10-11 | Adoptics Ag | Interfacial refraction accommodating lens (IRAL) |
WO2008097915A1 (en) | 2007-02-02 | 2008-08-14 | Key Medical Technologies, Inc. | Interfacial refraction accommodating lens (iral) |
US20080306587A1 (en) | 2007-02-21 | 2008-12-11 | Jingjong Your | Lens Material and Methods of Curing with UV Light |
US8158712B2 (en) | 2007-02-21 | 2012-04-17 | Powervision, Inc. | Polymeric materials suitable for ophthalmic devices and methods of manufacture |
US7986465B1 (en) | 2007-03-01 | 2011-07-26 | Rhevision Technology, Inc. | Systems and methods for effecting zoom and focus using fluidic adaptive lenses |
AU2008222293A1 (en) | 2007-03-05 | 2008-09-12 | Nulens Ltd | Unitary accommodating intraocular lenses (AIOLs) and discrete base members for use therewith |
EP2129345B8 (en) | 2007-03-13 | 2014-07-09 | Optimedica Corporation | Apparatus for creating ocular surgical and relaxing incisions |
US7753953B1 (en) | 2007-03-30 | 2010-07-13 | Kingman Yee | Accommodating intraocular lens system |
US8968396B2 (en) | 2007-07-23 | 2015-03-03 | Powervision, Inc. | Intraocular lens delivery systems and methods of use |
WO2009015226A2 (en) | 2007-07-23 | 2009-01-29 | Powervision, Inc. | Accommodating intraocular lenses and methods of use |
WO2009015161A2 (en) | 2007-07-23 | 2009-01-29 | Powervision, Inc. | Lens material with uv initiator and uv absorber and methods of curing with uv light |
JP5426547B2 (en) | 2007-07-23 | 2014-02-26 | パワーヴィジョン・インコーポレーテッド | Lens delivery system |
US9610155B2 (en) | 2008-07-23 | 2017-04-04 | Powervision, Inc. | Intraocular lens loading systems and methods of use |
US8314927B2 (en) | 2007-07-23 | 2012-11-20 | Powervision, Inc. | Systems and methods for testing intraocular lenses |
US8668734B2 (en) | 2010-07-09 | 2014-03-11 | Powervision, Inc. | Intraocular lens delivery devices and methods of use |
US8579971B2 (en) * | 2007-08-13 | 2013-11-12 | Garth T. Webb | Inflatable intra ocular lens/lens retainer |
US8377124B2 (en) | 2007-10-02 | 2013-02-19 | Novartis Ag | Two-element system to provide an ease of accommodation with variable-spherical aberration control |
US9717589B2 (en) | 2007-10-15 | 2017-08-01 | Akkolens International B.V. | Adjustable accommodating intraocular lens and positioning means |
CA2701510C (en) | 2007-11-14 | 2016-05-10 | Alcon, Inc. | Accommodative intraocular lens system |
US9156949B2 (en) | 2007-12-21 | 2015-10-13 | Abbott Medical Optics Inc. | Silicone containing polymeric materials |
US8414646B2 (en) | 2007-12-27 | 2013-04-09 | Forsight Labs, Llc | Intraocular, accommodating lens and methods of use |
EP3381407A1 (en) | 2008-01-03 | 2018-10-03 | Forsight Labs, Llc | Intraocular, accomodating lens and methods of use |
US20090198326A1 (en) | 2008-01-31 | 2009-08-06 | Medennium Inc. | Accommodative intraocular lens system |
US7998198B2 (en) | 2008-02-07 | 2011-08-16 | Novartis Ag | Accommodative IOL with dynamic spherical aberration |
US8254034B1 (en) | 2008-03-31 | 2012-08-28 | Rhevision Technology, Inc. | Fluidic adaptive lens with a lens membrane having suppressed fluid permeability |
ES2377456T3 (en) | 2008-07-24 | 2012-03-27 | Nulens Ltd | Accommodative intraocular lens capsules (IOLs) |
MX2011003671A (en) | 2008-10-15 | 2011-05-10 | Alcon Inc | Accommodating intraocular lens. |
US20120232649A1 (en) | 2008-11-20 | 2012-09-13 | Insight Innovations, Llc | Intraocular Lens Cell Migration Inhibition System |
US20100131059A1 (en) | 2008-11-26 | 2010-05-27 | Anew Optics, Inc. | Intraocular lens optic |
EP2384167A4 (en) | 2009-01-09 | 2016-02-17 | Powervision Inc | Intraocular lenses and methods of accounting for capsule size variability and post-implant changes in the eye |
US10299913B2 (en) | 2009-01-09 | 2019-05-28 | Powervision, Inc. | Accommodating intraocular lenses and methods of use |
WO2010093548A1 (en) | 2009-02-10 | 2010-08-19 | Alcon, Inc. | Accommodative intraocular lens system |
US8222360B2 (en) | 2009-02-13 | 2012-07-17 | Visiogen, Inc. | Copolymers for intraocular lens systems |
US8657878B2 (en) | 2009-02-18 | 2014-02-25 | Hoya Corporation | Interfacial refraction accommodating lens (IRAL) |
US20100211169A1 (en) | 2009-02-19 | 2010-08-19 | Daniel Walter Stanley | Intraocular lens configured to offset optical effects caused by optic deformation |
US20100288346A1 (en) | 2009-04-29 | 2010-11-18 | Gobi Ramakrishnan Padmanabhan | Configurations and methods to manufacture solar cell device with larger capture cross section and higher optical utilization efficiency |
US8320049B2 (en) | 2009-07-15 | 2012-11-27 | The Penn State Research Foundation | Tunable liquid gradient refractive index lens device |
US20110029074A1 (en) | 2009-08-03 | 2011-02-03 | Abbott Medical Optics Inc. | Fixation of ophthalmic implants |
JP5894076B2 (en) | 2009-08-31 | 2016-03-23 | パワーヴィジョン・インコーポレーテッド | Lens capsule size estimation method |
US20110071628A1 (en) | 2009-09-24 | 2011-03-24 | Rainbow Medical Ltd. | Accommodative intraocular lens |
US9622852B2 (en) | 2009-10-30 | 2017-04-18 | Akkolens International B.V. | Intraocular lenses for variable focus |
WO2011062826A2 (en) | 2009-11-17 | 2011-05-26 | Lu Kenneth L | Accommodating intraocular lens |
JP2013510697A (en) | 2009-11-17 | 2013-03-28 | アッコレンズ インターナショナル ビー.ヴイ. | Adjustable intraocular lens moved by the ciliary mass |
US8357196B2 (en) | 2009-11-18 | 2013-01-22 | Abbott Medical Optics Inc. | Mark for intraocular lenses |
GB2476480B (en) | 2009-12-22 | 2013-04-03 | Marwan Ghabra | Intraocular implant with a fixed and a pivoting lens |
US20120296424A1 (en) | 2010-01-26 | 2012-11-22 | Nir Betser | Accomodating intraocular lens |
JP2013520291A (en) | 2010-02-23 | 2013-06-06 | パワーヴィジョン・インコーポレーテッド | Liquid for accommodation type intraocular lens |
DE202010003217U1 (en) | 2010-03-05 | 2011-08-04 | Fluoron Gmbh | Filling material for ophthalmological implants |
US9034035B2 (en) | 2010-03-16 | 2015-05-19 | Mor Research Applications Ltd. | Accommodating intraocular lens assembly |
WO2011137191A1 (en) | 2010-04-27 | 2011-11-03 | Ramgopal Rao | Accommodating intraocular lens device |
US10736732B2 (en) | 2010-06-21 | 2020-08-11 | James Stuart Cumming | Intraocular lens with longitudinally rigid plate haptic |
BR112012033762A2 (en) | 2010-06-29 | 2018-02-27 | Univ Arizona | accommodation intraocular lens with deformable material |
CN103025271A (en) | 2010-08-15 | 2013-04-03 | 纽镜有限公司 | Discrete pre-assembled monolithic AIOL assemblages and AIOL assemblies including same |
ES2935571T3 (en) | 2011-02-03 | 2023-03-08 | Akkolens Int B V | Haptic combinations for accommodative intraocular lenses |
EP3685801A1 (en) | 2011-02-04 | 2020-07-29 | ForSight Vision6, Inc. | Intraocular accommodating lens |
US8867141B2 (en) | 2011-03-18 | 2014-10-21 | Johnson & Johnson Vision Care, Inc. | Lens with multi-concave meniscus wall |
EP2709574A2 (en) | 2011-05-16 | 2014-03-26 | Ico, Inc. | Filling and implanting accommodative intraocular lenses |
US20140227437A1 (en) | 2011-05-23 | 2014-08-14 | California Institute Of Technology | Accommodating intraocular lens |
AU2012259464B2 (en) | 2011-05-23 | 2017-01-05 | California Institute Of Technology | Accommodating intraocular lens |
US8715345B2 (en) | 2011-05-23 | 2014-05-06 | California Institute Of Technology | Accommodating intraocular lens |
US9186243B2 (en) | 2011-05-31 | 2015-11-17 | Novartis Ag | Accommodative intraocular lens and method of implantation |
US8257827B1 (en) | 2011-06-02 | 2012-09-04 | The Regents Of The University Of California | Silicone composition and devices incorporating same |
US8608800B2 (en) | 2011-08-02 | 2013-12-17 | Valdemar Portney | Switchable diffractive accommodating lens |
WO2013016804A1 (en) | 2011-08-03 | 2013-02-07 | Webb Garth T | Negatively pressurized deformable lens |
KR101866873B1 (en) | 2011-08-09 | 2018-06-14 | 삼성전자주식회사 | Device and method for variable curvature |
JP5594262B2 (en) | 2011-08-29 | 2014-09-24 | 信越化学工業株式会社 | Liquid addition-curing fluorosilicone rubber composition and molded product thereof |
US20130110234A1 (en) | 2011-10-28 | 2013-05-02 | Lauren DeVita | Dual optic accommodating iol with low refractive index gap material |
CN107753151B (en) | 2011-11-08 | 2020-12-15 | 爱尔康公司 | Accommodating intraocular lenses and methods of use |
US10433949B2 (en) | 2011-11-08 | 2019-10-08 | Powervision, Inc. | Accommodating intraocular lenses |
US9364319B2 (en) | 2012-09-25 | 2016-06-14 | Valdemar Portney | Refractive-diffractive switchable optical element |
US10080648B2 (en) | 2012-01-24 | 2018-09-25 | Clarvista Medical, Inc. | Modular intraocular lens designs, tools and methods |
US10028824B2 (en) | 2012-01-24 | 2018-07-24 | Clarvista Medical, Inc. | Modular intraocular lens designs, tools and methods |
US9364316B1 (en) | 2012-01-24 | 2016-06-14 | Clarvista Medical, Inc. | Modular intraocular lens designs, tools and methods |
EP2806828B1 (en) | 2012-01-24 | 2021-07-21 | The Regents of The University of Colorado, A Body Corporate | Modular intraocular lens designs and methods |
US8500806B1 (en) | 2012-01-31 | 2013-08-06 | Andrew F. Phillips | Accommodating intraocular lens |
US8900300B1 (en) | 2012-02-22 | 2014-12-02 | Omega Ophthalmics Llc | Prosthetic capsular bag and method of inserting the same |
CA2865954C (en) | 2012-03-21 | 2021-10-05 | Powervision, Inc. | Intraocular lens delivery systems and methods of use |
WO2013166068A1 (en) | 2012-04-30 | 2013-11-07 | Lensgen, Inc. | Method and system for adjusting the refractive power of an implanted intraocular lens |
US9084674B2 (en) | 2012-05-02 | 2015-07-21 | Abbott Medical Optics Inc. | Intraocular lens with shape changing capability to provide enhanced accomodation and visual acuity |
US9427312B2 (en) | 2012-05-25 | 2016-08-30 | California Institute Of Technology | Accommodating intraocular composite lens and related methods |
JP5872964B2 (en) | 2012-05-29 | 2016-03-01 | 東レ・ダウコーニング株式会社 | Conductive room temperature curable fluorosilicone rubber composition |
FR2992215B1 (en) | 2012-06-21 | 2014-10-31 | Oreal | ANHYDROUS COSMETIC COMPOSITION COMPRISING AN OIL, HYDROPHOBIC SILICA AEROGEL PARTICLES, A HYDROPHILIC ACTIVE INGREDIENT AND AT LEAST ONE SURFACTANT |
DE102012016893A1 (en) | 2012-08-24 | 2014-05-15 | Be Innovative Gmbh | Intraocular lens, in particular capsular bag intraocular lens |
DE102012016892A1 (en) | 2012-08-24 | 2014-02-27 | Be Innovative Gmbh | Intraocular lens, in particular ciliary intraocular lens |
US9622855B2 (en) | 2012-10-08 | 2017-04-18 | Valdemar Portney | Remote multifocal to monofocal optic conversion |
US20140107459A1 (en) | 2012-10-11 | 2014-04-17 | Alcon Research, Ltd. | Devices, systems, and methods for intraocular measurements |
WO2014063135A2 (en) | 2012-10-19 | 2014-04-24 | 1Co, Inc. | Systems and methods for customizing adjustable intraocular lenses |
US20140121768A1 (en) | 2012-10-31 | 2014-05-01 | Novartis Ag | Accommodating intraocular lens with ciliary body activation |
US20140135917A1 (en) | 2012-11-13 | 2014-05-15 | Vision Solutions Technologies, Inc. | Multi-focus intraocular prosthesis |
WO2014099345A1 (en) | 2012-12-18 | 2014-06-26 | Novartis Ag | Presbyopia-correcting iol using curvature change of an air chamber |
US9186244B2 (en) | 2012-12-21 | 2015-11-17 | Lensgen, Inc. | Accommodating intraocular lens |
EP2908775B1 (en) | 2012-12-21 | 2017-08-30 | Novartis AG | Curvature changing accommodative intraocular lens |
US20140180406A1 (en) | 2012-12-21 | 2014-06-26 | Novartis Ag | Accommodating intraocular lens |
WO2014099759A1 (en) | 2012-12-21 | 2014-06-26 | Novartis Ag | Intraocular lens system for monofocal vision at multiple pre-defined focal points |
AU2013363516A1 (en) | 2012-12-21 | 2015-05-14 | Novartis Ag | Curvature changing accommodative intraocular lens |
US20140180407A1 (en) | 2012-12-26 | 2014-06-26 | Rainbow Medical Ltd. | Accommodative intraocular lens |
US20140309734A1 (en) | 2012-12-26 | 2014-10-16 | Rainbow Medical Ltd. | Accommodative intraocular lens |
US9925039B2 (en) | 2012-12-26 | 2018-03-27 | Rainbow Medical Ltd. | Accommodative intraocular lens |
US9486311B2 (en) | 2013-02-14 | 2016-11-08 | Shifamed Holdings, Llc | Hydrophilic AIOL with bonding |
EP2945571B1 (en) | 2013-02-28 | 2018-04-25 | HONIGSBAUM, Richard F. | Tensioning rings for anterior capsules and accommodative intraocular lenses for use therewith |
US20140257479A1 (en) | 2013-03-11 | 2014-09-11 | Sean J. McCafferty | Refocusable intraocular lens with flexible aspherical surface |
US20140257478A1 (en) | 2013-03-07 | 2014-09-11 | Sean J. McCafferty | Accommodating fluidic intraocular lens with flexible interior membrane |
US9277988B1 (en) | 2013-03-15 | 2016-03-08 | Milton W. Chu | Intraocular lenses with quantum dots |
ES2834479T3 (en) | 2013-03-15 | 2021-06-17 | Alcon Inc | Method of reconfiguring an intraocular lens for delivery to a delivery device |
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US10195018B2 (en) | 2013-03-21 | 2019-02-05 | Shifamed Holdings, Llc | Accommodating intraocular lens |
US9861469B2 (en) | 2013-05-07 | 2018-01-09 | Akkolens International B.V. | Accommodating intraocular lens with haptics for sulcus fixation |
EP3782584B1 (en) | 2013-06-03 | 2023-07-12 | Alcon Inc. | Modular intraocular lens designs |
JP6473440B2 (en) | 2013-08-28 | 2019-02-20 | 東レ・ダウコーニング株式会社 | Curable silicone composition, cured product thereof, and optical semiconductor device |
EP2851038A1 (en) | 2013-09-24 | 2015-03-25 | Consejo Superior De Investigaciones Cientificas | Intraocular lens with accomodation capacity |
JP2016534816A (en) | 2013-11-01 | 2016-11-10 | レンスゲン、インコーポレイテッド | Two-part adjustable intraocular lens device |
WO2015066502A1 (en) | 2013-11-01 | 2015-05-07 | Thomas Silvestrini | Accomodating intraocular lens device |
KR20160088894A (en) | 2013-11-20 | 2016-07-26 | 다우 코닝 코포레이션 | Organosiloxane compositions |
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US20150173892A1 (en) | 2013-12-23 | 2015-06-25 | Novartis Ag | Accommodating intraocular lens |
CA3184269A1 (en) | 2014-02-18 | 2015-08-27 | Alcon, Inc. | Modular intraocular lens designs, tools and methods |
CA2941015C (en) | 2014-03-07 | 2019-11-12 | Conexus Lens, Inc. | Refocusable lens system with mutually-applanating internal surfaces |
US9333072B2 (en) | 2014-04-29 | 2016-05-10 | Chukyo Medical Co., Inc. | Intraocular lens |
WO2015195825A1 (en) | 2014-06-19 | 2015-12-23 | Omega Ophthalmics Llc | Prostheticcapsular devices, systems, and methods |
US10004596B2 (en) | 2014-07-31 | 2018-06-26 | Lensgen, Inc. | Accommodating intraocular lens device |
US20160051361A1 (en) | 2014-08-21 | 2016-02-25 | Emmetrope Incorporated | Accommodating Intraocular Lens |
JP6267832B2 (en) | 2014-08-26 | 2018-01-24 | シファメド・ホールディングス・エルエルシー | Adjustable intraocular lens |
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US9358103B1 (en) | 2015-02-10 | 2016-06-07 | Omega Ophthalmics Llc | Prosthetic capsular devices, systems, and methods |
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WO2016160952A1 (en) | 2015-03-30 | 2016-10-06 | Wendian Shi | Fluid-filled implantable structures with internal surface-modifying components and related methods |
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WO2017079733A1 (en) | 2015-11-06 | 2017-05-11 | Powervision, Inc. | Accommodating intraocular lenses and methods of manufacturing |
ES2617579B1 (en) | 2015-11-16 | 2018-04-10 | Lens Undergone Zonula Global, S.L. | IMPROVED ACCOMMODATION INTRAOCULAR LENS |
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US10526353B2 (en) | 2016-05-27 | 2020-01-07 | Lensgen, Inc. | Lens oil having a narrow molecular weight distribution for intraocular lens devices |
CA3026494C (en) | 2016-06-06 | 2022-06-07 | Omega Ophthalmics Llc | Prosthetic capsular devices, systems, and methods |
US10159566B2 (en) | 2016-09-26 | 2018-12-25 | Novartis Ag | Heat tunable intraocular lens |
EP3528747B1 (en) | 2016-10-21 | 2021-09-15 | Omega Ophthalmics LLC | Prosthetic capsular devices |
EA037705B1 (en) | 2016-10-28 | 2021-05-12 | Форсайт Вижн6, Инк. | Accommodating intraocular lens and system for implantation in an eye |
JP6954679B2 (en) | 2016-12-23 | 2021-10-27 | シファメド・ホールディングス・エルエルシー | Multi-piece adjustable intraocular lens, and how to make and use it |
US10350056B2 (en) | 2016-12-23 | 2019-07-16 | Shifamed Holdings, Llc | Multi-piece accommodating intraocular lenses and methods for making and using same |
AU2018233971A1 (en) | 2017-03-13 | 2019-10-03 | Kejako Sa | Accommodative lens device |
US10918476B2 (en) | 2017-03-30 | 2021-02-16 | Verily Life Sciences Llc | Electrowetting intraocular lens with isotonic aqueous phase |
US11409134B2 (en) | 2017-04-19 | 2022-08-09 | Amo Groningen B.V. | Electrowetting and photo curing for manufacturing of ophthalmic lenses |
US11197752B2 (en) | 2017-05-05 | 2021-12-14 | Verily Life Sciences Llc | Situ filling and sealing of electrowetting intraocular lenses |
JP7370052B2 (en) | 2017-05-30 | 2023-10-27 | シファメド・ホールディングス・エルエルシー | Surface treatments and related methods and devices for accommodating intraocular lenses |
WO2018227014A1 (en) | 2017-06-07 | 2018-12-13 | Shifamed Holdings, Llc | Adjustable optical power intraocular lenses |
US11382736B2 (en) | 2017-06-27 | 2022-07-12 | Alcon Inc. | Injector, intraocular lens system, and related methods |
US10716661B2 (en) | 2017-07-17 | 2020-07-21 | Verily Life Sciences Llc | Accommodating intraocular lens with meniscus |
US20200253723A1 (en) | 2017-07-31 | 2020-08-13 | Douglas Michael Ackermann | Pupillary accommodating intraocular lens |
US20190069989A1 (en) | 2017-09-06 | 2019-03-07 | Verily Life Sciences Llc | Multipart electrowetting intraocular lens for in-situ assembly |
WO2019236908A1 (en) | 2018-06-07 | 2019-12-12 | Lensgen, Inc. | Intraocular lens devices and related methods |
-
2011
- 2011-04-27 WO PCT/US2011/034197 patent/WO2011137191A1/en active Application Filing
- 2011-04-27 JP JP2013508225A patent/JP2013525028A/en active Pending
- 2011-04-27 CN CN201180021257XA patent/CN102883682A/en active Pending
- 2011-04-27 EP EP11775538.9A patent/EP2563275A4/en not_active Withdrawn
-
2012
- 2012-10-26 US US13/662,087 patent/US20130053954A1/en not_active Abandoned
-
2018
- 2018-06-01 US US15/995,671 patent/US10772721B2/en active Active
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4932966A (en) * | 1988-08-15 | 1990-06-12 | Storz Instrument Company | Accommodating intraocular lens |
US20060212116A1 (en) * | 2002-10-25 | 2006-09-21 | Advanced Medical Optics, Inc. | Capsular intraocular lens implant having a refractive liquid therein |
US20090149952A1 (en) * | 2003-02-03 | 2009-06-11 | Shadduck John H | Intraocular Lenses and Business Methods |
US20120245683A1 (en) * | 2009-12-04 | 2012-09-27 | Acufocus, Inc. | Corneal implant for refractive correction |
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Also Published As
Publication number | Publication date |
---|---|
CN102883682A (en) | 2013-01-16 |
JP2013525028A (en) | 2013-06-20 |
EP2563275A4 (en) | 2017-11-22 |
WO2011137191A1 (en) | 2011-11-03 |
EP2563275A1 (en) | 2013-03-06 |
US20190000612A1 (en) | 2019-01-03 |
US10772721B2 (en) | 2020-09-15 |
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