US20120065673A1 - Septal defect closure device - Google Patents
Septal defect closure device Download PDFInfo
- Publication number
- US20120065673A1 US20120065673A1 US13/300,866 US201113300866A US2012065673A1 US 20120065673 A1 US20120065673 A1 US 20120065673A1 US 201113300866 A US201113300866 A US 201113300866A US 2012065673 A1 US2012065673 A1 US 2012065673A1
- Authority
- US
- United States
- Prior art keywords
- covering member
- defect
- wire
- delivery
- configuration
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/0057—Implements for plugging an opening in the wall of a hollow or tubular organ, e.g. for sealing a vessel puncture or closing a cardiac septal defect
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/064—Surgical staples, i.e. penetrating the tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/064—Surgical staples, i.e. penetrating the tissue
- A61B17/0644—Surgical staples, i.e. penetrating the tissue penetrating the tissue, deformable to closed position
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/0057—Implements for plugging an opening in the wall of a hollow or tubular organ, e.g. for sealing a vessel puncture or closing a cardiac septal defect
- A61B2017/00575—Implements for plugging an opening in the wall of a hollow or tubular organ, e.g. for sealing a vessel puncture or closing a cardiac septal defect for closure at remote site, e.g. closing atrial septum defects
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/0057—Implements for plugging an opening in the wall of a hollow or tubular organ, e.g. for sealing a vessel puncture or closing a cardiac septal defect
- A61B2017/00575—Implements for plugging an opening in the wall of a hollow or tubular organ, e.g. for sealing a vessel puncture or closing a cardiac septal defect for closure at remote site, e.g. closing atrial septum defects
- A61B2017/00592—Elastic or resilient implements
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/0057—Implements for plugging an opening in the wall of a hollow or tubular organ, e.g. for sealing a vessel puncture or closing a cardiac septal defect
- A61B2017/00575—Implements for plugging an opening in the wall of a hollow or tubular organ, e.g. for sealing a vessel puncture or closing a cardiac septal defect for closure at remote site, e.g. closing atrial septum defects
- A61B2017/00615—Implements with an occluder on one side of the opening and holding means therefor on the other
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/0057—Implements for plugging an opening in the wall of a hollow or tubular organ, e.g. for sealing a vessel puncture or closing a cardiac septal defect
- A61B2017/00637—Implements for plugging an opening in the wall of a hollow or tubular organ, e.g. for sealing a vessel puncture or closing a cardiac septal defect for sealing trocar wounds through abdominal wall
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/0057—Implements for plugging an opening in the wall of a hollow or tubular organ, e.g. for sealing a vessel puncture or closing a cardiac septal defect
- A61B2017/00646—Type of implements
- A61B2017/00659—Type of implements located only on one side of the opening
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B2017/00831—Material properties
- A61B2017/00867—Material properties shape memory effect
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/064—Surgical staples, i.e. penetrating the tissue
- A61B2017/0641—Surgical staples, i.e. penetrating the tissue having at least three legs as part of one single body
Definitions
- This application relates to a closure device and more particularly to a device for closing septal defects such as the patent foramen ovale.
- Septal defects are perforations in the septum, a wall dividing two cavities, such as the atria of the heart. Atrial defects can occur congenitally (by birth) or develop later such as after a heart attack.
- the foramen ovale is a valve-like opening between the two atria of the heart in the fetus. In most cases, it closes shortly before or after birth as fibrous tissue growth seals the opening. However, in some cases, the opening (defect) remains open (patent), allowing blood to shunt across the defect from the left atrium to the right atrium. This means that the un-oxygenated blood flows directly from the right side to the left side of the heart, where it travels through the aorta to the brain and other parts of the body. This can lead to life-threatening strokes as clots can travel to the brain. Additionally, since blood shunts from the higher pressure left ventricle into the lower pressure right side heart chambers and pulmonary arteries, this increase in flow at the high pressure can cause cardiac failure and even death.
- One approach to treatment to prevent travel of the life-threatening blood clots is the administration of medications to break up the blood clots.
- these blood thinning medications are expensive, increase the risk of bleeding and could have adverse side effects.
- Another approach is to perform invasive open heart surgery to close off the patent foramen ovale (PFO) by suturing the tissue to close the opening or by suturing a patch to cover the defect.
- PFO patent foramen ovale
- Such minimally invasive devices need to be collapsible to a small enough dimension to enable delivery through a small incision while being expandable to a sufficiently large dimension with sufficient stability to ensure sealing of the septal defect.
- Providing a low profile once positioned is also advantageous because it minimizes disruption of blood flow.
- the present invention overcomes the problems and deficiencies of the prior art.
- the present invention provides a device for closing a septal defect of a patient.
- the device comprises a covering member and at least one retaining leg.
- the covering member has a first configuration for delivery and a second larger configuration for placement on a first side of the defect.
- the covering member has a dimension at least equal to the size of the defect to cover the defect.
- the at least one retaining leg is configured to contact tissue on a second side of the defect to retain the covering member and has a first reduced profile configuration for delivery and a second configuration for placement on the second side of the defect.
- the covering member includes a support in the form of a wire composed of shape memory material and is substantially ring or disc-shaped in the second configuration wherein movement of the support to the second configuration expands the covering member.
- the at least one retaining leg is composed of shape memory material.
- the at least one retaining leg comprises two legs, wherein in the second configuration the two legs curve radially outwardly in different directions to engage tissue on the second side of the defect.
- the at least one retaining leg comprises four legs.
- the covering member is placed on a distal side of the defect and the at least one retaining leg is placed on a proximal side of the defect.
- the present invention also provides a method of closing a septal defect comprising:
- the step of delivering the covering member occurs prior to the expansion of the covering member.
- the covering member has an expandable wire positioned therein composed of shape memory material so that upon delivery the wire expands to expand the covering member to the placement configuration.
- the at least one retaining member is composed of shape memory material so that upon delivery, the retaining member automatically moves to a curved placement position.
- the at least one retaining member comprises first and second legs.
- FIG. 1 is a perspective view of a first embodiment of the closure device of the present invention shown in the placement configuration
- FIG. 2 is a bottom view of the closure device of FIG. 1 ;
- FIG. 3 is a side view of the closure device of FIG. 1 ;
- FIG. 4 is a perspective view of a delivery instrument for delivering the closure device of FIG. 1 to the surgical site;
- FIG. 5 is a longitudinal cross-sectional view taken along line 5 - 5 of FIG. 4 showing the closure device in the collapsed position within the delivery tube for delivery to the surgical site, the expanding wire positioned within the covering member;
- FIG. 6 is a transverse cross-sectional view taken along line 6 - 6 of FIG. 5 ;
- FIG. 7 is a longitudinal cross-sectional view similar to FIG. 5 showing an alternate method of delivering the closure device wherein in the collapsed position of the closure device, the expanding wire is positioned mostly outside the covering member for later advancement into the covering member;
- FIG. 8 is a transverse cross-sectional view taken along line 8 - 8 of FIG. 7 ;
- FIGS. 9-12 illustrate the method of delivering the closure device to the atria to repair a septal defect wherein:
- FIG. 9 illustrates the delivery catheter inserted via a femoral approach to access the septal defect, the catheter extending from the femoral artery to a position adjacent the septal defect between the atria of the heart;
- FIG. 10 is an enlarged view of the area of detail in FIG. 9 showing the covering member starting to be inserted through the defect;
- FIG. 11 is a view similar to FIG. 10 showing further advancement of the covering member from the delivery device by distal advancement of the pusher in the direction of the arrow;
- FIG. 12 is a view similar to FIG. 11 showing full advancement of the covering member from the delivery device and partial advancement of the wire into the covering member to expand the covering member;
- FIG. 13 is a perspective view in the same area of detail of FIG. 12 illustrating the closure device fully deployed to close the septal defect;
- FIG. 14 illustrates the anatomical placement of the closure device of FIG. 13 in the septal defect between the atria of the heart
- FIG. 15 is an enlarged view of the area detailed in FIG. 14 to show placement of the closure device
- FIG. 16 is a perspective view of an alternate embodiment of the closure device of the present invention having four clip legs to retain the covering member;
- FIG. 17 is a perspective view of another alternate embodiment of the present invention wherein the clip legs are placed on the distal side of the defect and the covering member is placed on the proximal side.
- the present invention provides a closure device for closing the patent foramen ovale (PFO) and a delivery system for placement of the closure device.
- the closure device 10 includes a clip component 12 and a covering member or patch 20 .
- the covering member (patch) 20 is expandable within the atrium, on a distal side of the defect, and is retained in position by legs 14 and 16 of clip 12 which engage the tissue on the proximal side of the defect.
- the closure device further includes a wire 30 having an annular shape as shown in FIG.
- the wire 30 is configured to expand the covering member 20 to a diameter of at least equal to and preferably greater than, the size of the defect to provide a patch on the distal side of the PFO.
- the expanded member 20 thereby blocks the opening to prevent blood flow from the left atrium to the right atrium.
- the delivery system for the closure device includes a catheter or delivery tube 50 , a pusher 60 for advancing the patch 20 and attached clip 12 and a pusher (not shown) for advancing the wire 30 into the patch.
- Pusher 60 has an axial lumen 64 to slidably receive the wire pusher.
- the pusher can in one embodiment (not shown) be removably attached to the patch and detachable to separate the pusher after the patch 20 has been properly placed at the desired surgical site.
- One way of achieving this detachable connection is by providing a screw thread (not shown) on the distal end of the pusher. Such attachment is shown in co-pending patent application Ser. No. 60/674,321, filed Apr.
- the screw thread would thread into a support connected to a proximal end of the patch 20 .
- Axial movement of the pusher would advance the patch 20 ; rotational movement of the pusher would unscrew it from the support.
- Other ways to removably connect the pusher to the patch are also contemplated.
- the clip 12 functions as a retaining member and preferably includes two clip legs 14 , 16 extending distally from patch 20 , preferably in opposite directions.
- the legs 14 , 16 can be attached to the patch by adhesive or other means.
- These retaining legs 14 , 16 are dimensioned and configured to engage tissue adjacent the defect on the proximal side P (see e.g., FIG. 14 ) to help retain the closure device 10 in position.
- the clip legs 14 , 16 are composed of shape memory material, such as Nitinol, with an austenitic shape memorized position illustrated in FIGS. 1 and 3 . Materials other than Nitinol or shape memory are also contemplated.
- the clip legs can be formed of a single wire or separate wires or material.
- the clip legs 14 , 16 are maintained in a substantially straightened softer martensitic configuration within the catheter 50 for delivery as shown in FIG. 5 .
- Cold saline can be injected during delivery to maintain the legs 14 , 16 in this martensitic condition to facilitate exit from the distal opening 52 at the distal end portion 54 of catheter 50 .
- legs 14 , 16 exit the delivery tube 50 , they are warmed by body temperature and move radially in different (e.g., opposite) directions toward their illustrated memorized curved position as shown for example in FIG. 3 .
- the extent to which the clip legs return to their memorized position will depend on the thickness and resistance of the tissue.
- a single clip leg or more than two clip legs could be provided.
- FIG. 16 illustrates by way of example four clip legs.
- the four clips legs 114 , 116 , 118 , and 120 are spaced about 90 degrees apart and provided to retain the patch 122 .
- the clip legs in these various embodiments could include penetrating tips to engage and penetrate the tissue or blunt tips to just engage the tissue. Blunt tips, e.g., tips 14 a, 16 a, 114 a, 116 a, 118 a, and 120 a, are shown in the illustrated embodiments.
- the patch 20 can be composed of a variety of materials, such as PFTE, polyethylene, swine intestinal submucosa, endothelium and/or other native tissues such as vein, artery, umbilical, or pericardium as either an allograft or xenograft.
- the patch could be coated with a hydrophilic, heparin, anti-platelet or anti-thrombogenic coating.
- the patch 20 is in the collapsed configuration within catheter 50 for delivery as shown in FIG. 5 or further rolled as in FIG. 7 ; it is expanded by the wire 30 to the configuration of FIGS. 1-3 .
- the wire 30 is preferably composed of shape memory material, such as Nitinol, with an austenitic annular shaped memorized position illustrated in FIGS. 2 and 3 .
- shape memory material such as Nitinol
- austenitic annular shaped memorized position illustrated in FIGS. 2 and 3 .
- materials other than Nitinol are also contemplated.
- the wire 30 When advanced from the delivery tube 50 , the wire 30 is warmed by body temperature and moves from its delivery configuration of FIG. 5 to its memorized annular configuration within patch 20 . That is, wire 30 is maintained in a softer martensitic configuration within the catheter or patch to reduce its profile (overall transverse dimension) for delivery. Cold saline can be injected during delivery to maintain the wire 30 in this martensitic condition to facilitate exit from the distal opening 52 at the distal end portion 54 of catheter 50 . In the memorized position, the wire assumes an annular shape along the inside periphery of the patch 20 . As shown it extends more than 360 degrees as portion 32 of wire 30 overlaps an annular portion of the wire (see FIG. 3 ).
- FIGS. 7 and 8 differs from the embodiment of FIGS. 5 and 6 in that the expanding wire 30 ′ is fed into the patch 20 in situ. That is, instead of delivering the patch with the wire already inside as in FIGS. 5 and 6 , the wire is advanced into the patch in a separate step after the patch is released to the distal side of the defect. This is explained in detail below in conjunction with the method of placement.
- the wire 30 is contained within the patch 20 during delivery so upon ejection of the patch 20 from delivery tube 50 , the patch 20 automatically expands. This avoids the additional step of advancing the wire (the step of FIG. 12 ). However, it slightly increases the overall delivery profile since the patch cannot collapse to the same degree because of the wire contained therein.
- the wire 30 ′ is contained in an elongated substantially straight delivery configuration to provide a smaller profile.
- the delivery catheter 50 is inserted through an introducer sheath in the femoral vein and advanced to access the atria as shown in FIG. 9 .
- the patch 20 , clip 12 and wire 30 are all in the collapsed position. That is, as shown in FIG. 7 , the clip legs 14 , 16 are in a substantially straight position.
- the wire 30 ′ is also in a substantially straight position and patch 20 is collapsed and could be partially rolled. This provides for a reduced profile insertion configuration.
- FIG. 10 shows a close-up view of the catheter distal end positioned adjacent the septal opening.
- pusher 60 is advanced distally, (e.g., by a handle (not shown) or other mechanism) at a proximal end of the catheter 50 in the direction of arrow F of FIG. 10 .
- Distal advancement of pusher 60 advances the closure device from the catheter 50 as the distal end 62 of pusher 60 abuts patch 20 . That is, advancement of the pusher in the direction of arrow F of FIG. 10 advances patch 20 from catheter 50 into the right atrium (see FIG. 11 ) on the distal side D of the defect.
- the patch 20 remains at this point in the collapsed configuration. Once fully ejected, it still remains in an unexpanded configuration.
- the wire pusher (not shown) is advanced distally in the direction of arrow E of FIG. 12 so engagement of the distal end of the wire pusher with the proximal end 31 of wire 30 ′ will force wire 30 ′ into the patch 20 .
- the wire 30 ′ exits the catheter 50 and enters the patch 20 within the right atrium, it is warmed by body temperature and moves toward its shape memorized overlapping annular configuration.
- This annular configuration expands patch 20 into a disk shape or a ring shape.
- FIG. 13 illustrates the patch 20 in an expanded configuration due to the movement of the wire to its memorized configuration.
- the wire pusher can have a radiopaque marker which can align with the radiopaque marker 56 on the catheter 50 . This will provide a visual indication to the user that the pusher has completed its travel and the wire 30 ′ has been inserted as the two markers align and provide a relatively large solid area for imaging. This will occur on full advancement of the wire pusher.
- a radiopaque marker can also be provided at the base of legs 14 , 16 adjacent the patch 20 for imaging. Alignment of the radiopaque members is described in application Ser. No. 60/674,321 referenced above.
- the pusher 60 along with the catheter 50 are withdrawn, releasing the clip legs 12 , 14 from the catheter to the proximal side P of the opening to enable movement toward their memorized curved position as they are warmed by body temperature.
- Withdrawal of the catheter 50 leaves the closure device 10 in place as shown in FIGS. 13 , 14 and 15 .
- the patch 20 will be positioned at the distal side opening to block the opening (defect) in the atrium to prevent blood flow from the left atrium (proximal side) to the right atrium through the defect.
- the patch is placed on the proximal side of the defect and the legs are placed on the distal side. This is shown in FIG. 17 , wherein patch 220 is placed on the proximal side P of the defect and the retaining legs 214 , 216 are placed on the distal side D.
Abstract
A device for closing a septal defect of a patient comprising a covering member and at least one retaining leg. The covering member has a first configuration for delivery and a second configuration for placement on the first side of the defect. The at least one retaining leg is configured to contact tissue on the second side of the defect to retain the covering member and has a first configuration for delivery and a second configuration for placement on the second side of the defect.
Description
- This application is a continuation-in-part of U.S. patent application Ser. No. 10/847,141, filed May 17, 2004, which is a continuation-in-part of application Ser. No. 10/345,533, filed Jan. 16, 2003, which is a continuation-in-part of application Ser. No. 10/163,142, filed Jun. 5, 2002, which claims priority from provisional application Ser. No. 60/355,526, filed Feb. 6, 2002, and which is a continuation-in-part of application Ser. No. 09/659,648, filed Sep. 12, 2000, which claims priority from provisional patent application Ser. No. 60/153,736, filed Sep. 13, 1999. The contents of each of these applications are incorporated herein by reference in their entirety.
- 1. Technical Field
- This application relates to a closure device and more particularly to a device for closing septal defects such as the patent foramen ovale.
- 2. Background of Related Art
- Septal defects are perforations in the septum, a wall dividing two cavities, such as the atria of the heart. Atrial defects can occur congenitally (by birth) or develop later such as after a heart attack.
- One type of atrial defect is the foramen ovale. The foramen ovale is a valve-like opening between the two atria of the heart in the fetus. In most cases, it closes shortly before or after birth as fibrous tissue growth seals the opening. However, in some cases, the opening (defect) remains open (patent), allowing blood to shunt across the defect from the left atrium to the right atrium. This means that the un-oxygenated blood flows directly from the right side to the left side of the heart, where it travels through the aorta to the brain and other parts of the body. This can lead to life-threatening strokes as clots can travel to the brain. Additionally, since blood shunts from the higher pressure left ventricle into the lower pressure right side heart chambers and pulmonary arteries, this increase in flow at the high pressure can cause cardiac failure and even death.
- One approach to treatment to prevent travel of the life-threatening blood clots is the administration of medications to break up the blood clots. However, these blood thinning medications are expensive, increase the risk of bleeding and could have adverse side effects. Another approach is to perform invasive open heart surgery to close off the patent foramen ovale (PFO) by suturing the tissue to close the opening or by suturing a patch to cover the defect. Such invasive open heart surgery is time consuming, traumatic to the patient, increases patient risk and recovery time, and increases costs as extended hospital stays are required.
- It is therefore recognized that a minimally invasive approach to closing the septal defect to prevent the aforementioned migration of blood clots into cranial circulation and prevent cardiac overwork by high pressure flow would be beneficial. These devices, however, need to meet several criteria.
- Such minimally invasive devices need to be collapsible to a small enough dimension to enable delivery through a small incision while being expandable to a sufficiently large dimension with sufficient stability to ensure sealing of the septal defect. The smaller the profile when collapsed the better the access and insertion. Providing a low profile once positioned is also advantageous because it minimizes disruption of blood flow.
- There have been several attempts in the prior art to provide minimally invasive devices for closing a PFO. For example, in U.S. Pat. No. 5,846,261, a tubular wire braid of shape memory metal fabric is placed in the opening. In U.S. Pat. No. 5,944,738, two discs of braided shape memory wires are utilized. In U.S. Pat. No. 5,425,744, two Dacron covered shape memory frameworks are connected by a wire. In U.S. Pat. No. 5,861,003, two sacs of porous material supported by a wire frame are placed on opposing sides of the opening. In U.S. Pat. No. 6,712,836, a shape memory frame with fingers on both sides of the aperture to hold the plugging structure made of cloth or Dacron which extends through the aperture is disclosed.
- It would be advantageous however to provide a device which provides stability to maintain the device position. It would also be advantageous to provide a device which presents a lower implantation profile as well as a lower insertion profile. This would minimize the insertion profile, facilitate passage to and through the defect, and provide less interference with blood flow.
- Commonly assigned U.S. Pat. No. 10/847,141, filed May 17, 2004, discloses a device for closing vessel apertures. The present application provides a closure device with a reduced profile internally supported patch adapted for closing septal defects such as the patent foramen ovale.
- The present invention overcomes the problems and deficiencies of the prior art. The present invention provides a device for closing a septal defect of a patient. The device comprises a covering member and at least one retaining leg. The covering member has a first configuration for delivery and a second larger configuration for placement on a first side of the defect. The covering member has a dimension at least equal to the size of the defect to cover the defect. The at least one retaining leg is configured to contact tissue on a second side of the defect to retain the covering member and has a first reduced profile configuration for delivery and a second configuration for placement on the second side of the defect.
- In a preferred embodiment, the covering member includes a support in the form of a wire composed of shape memory material and is substantially ring or disc-shaped in the second configuration wherein movement of the support to the second configuration expands the covering member. In a preferred embodiment, the at least one retaining leg is composed of shape memory material. In one embodiment, the at least one retaining leg comprises two legs, wherein in the second configuration the two legs curve radially outwardly in different directions to engage tissue on the second side of the defect. In an alternate embodiment, the at least one retaining leg comprises four legs.
- In a preferred embodiment, the covering member is placed on a distal side of the defect and the at least one retaining leg is placed on a proximal side of the defect.
- The present invention also provides a method of closing a septal defect comprising:
-
- providing a covering member for delivery to a distal side of the septal defect, the covering member having a dimension at least equal to a size of the defect to cover the defect;
- delivering the covering member in a collapsed position to the distal side of the septal defect, the covering member moving to a placement configuration to cover the distal side of the defect; and
- delivering at least one retaining member in an elongated position to a proximal side of the defect, the retaining member moving to a curved position to engage tissue on the proximal side of the defect to retain the covering member on the distal side of the defect.
- In one embodiment, the step of delivering the covering member occurs prior to the expansion of the covering member. In another embodiment, the covering member has an expandable wire positioned therein composed of shape memory material so that upon delivery the wire expands to expand the covering member to the placement configuration. In a preferred embodiment, the at least one retaining member is composed of shape memory material so that upon delivery, the retaining member automatically moves to a curved placement position. In a preferred embodiment, the at least one retaining member comprises first and second legs.
- Preferred embodiment(s) of the present disclosure are described herein with reference to the drawings wherein:
-
FIG. 1 is a perspective view of a first embodiment of the closure device of the present invention shown in the placement configuration; -
FIG. 2 is a bottom view of the closure device ofFIG. 1 ; -
FIG. 3 is a side view of the closure device ofFIG. 1 ; -
FIG. 4 is a perspective view of a delivery instrument for delivering the closure device ofFIG. 1 to the surgical site; -
FIG. 5 is a longitudinal cross-sectional view taken along line 5-5 ofFIG. 4 showing the closure device in the collapsed position within the delivery tube for delivery to the surgical site, the expanding wire positioned within the covering member; -
FIG. 6 is a transverse cross-sectional view taken along line 6-6 ofFIG. 5 ; -
FIG. 7 is a longitudinal cross-sectional view similar toFIG. 5 showing an alternate method of delivering the closure device wherein in the collapsed position of the closure device, the expanding wire is positioned mostly outside the covering member for later advancement into the covering member; -
FIG. 8 is a transverse cross-sectional view taken along line 8-8 ofFIG. 7 ; -
FIGS. 9-12 illustrate the method of delivering the closure device to the atria to repair a septal defect wherein: -
FIG. 9 illustrates the delivery catheter inserted via a femoral approach to access the septal defect, the catheter extending from the femoral artery to a position adjacent the septal defect between the atria of the heart; -
FIG. 10 is an enlarged view of the area of detail inFIG. 9 showing the covering member starting to be inserted through the defect; -
FIG. 11 is a view similar toFIG. 10 showing further advancement of the covering member from the delivery device by distal advancement of the pusher in the direction of the arrow; -
FIG. 12 is a view similar toFIG. 11 showing full advancement of the covering member from the delivery device and partial advancement of the wire into the covering member to expand the covering member; -
FIG. 13 is a perspective view in the same area of detail ofFIG. 12 illustrating the closure device fully deployed to close the septal defect; -
FIG. 14 illustrates the anatomical placement of the closure device ofFIG. 13 in the septal defect between the atria of the heart; -
FIG. 15 is an enlarged view of the area detailed inFIG. 14 to show placement of the closure device; -
FIG. 16 is a perspective view of an alternate embodiment of the closure device of the present invention having four clip legs to retain the covering member; and -
FIG. 17 is a perspective view of another alternate embodiment of the present invention wherein the clip legs are placed on the distal side of the defect and the covering member is placed on the proximal side. - Referring now in detail to the drawings where like reference numerals identify similar or like components throughout the several views, the present invention provides a closure device for closing the patent foramen ovale (PFO) and a delivery system for placement of the closure device. With initial reference to
FIGS. 1-3 which show the closure device in the deployed (placement) configuration, theclosure device 10 includes aclip component 12 and a covering member orpatch 20. The covering member (patch) 20 is expandable within the atrium, on a distal side of the defect, and is retained in position bylegs clip 12 which engage the tissue on the proximal side of the defect. The closure device further includes awire 30 having an annular shape as shown inFIG. 2 to extend around at least an inside perimeter of the coveringmember 20 to form it into a disc or ring shape. Thewire 30 is configured to expand the coveringmember 20 to a diameter of at least equal to and preferably greater than, the size of the defect to provide a patch on the distal side of the PFO. The expandedmember 20 thereby blocks the opening to prevent blood flow from the left atrium to the right atrium. - With reference to
FIGS. 4-6 , the delivery system for the closure device includes a catheter ordelivery tube 50, apusher 60 for advancing thepatch 20 and attachedclip 12 and a pusher (not shown) for advancing thewire 30 into the patch.Pusher 60 has anaxial lumen 64 to slidably receive the wire pusher. The pusher can in one embodiment (not shown) be removably attached to the patch and detachable to separate the pusher after thepatch 20 has been properly placed at the desired surgical site. One way of achieving this detachable connection is by providing a screw thread (not shown) on the distal end of the pusher. Such attachment is shown in co-pending patent application Ser. No. 60/674,321, filed Apr. 22, 2005, the entire contents of which are incorporated herein by reference. The screw thread would thread into a support connected to a proximal end of thepatch 20. Axial movement of the pusher would advance thepatch 20; rotational movement of the pusher would unscrew it from the support. Other ways to removably connect the pusher to the patch are also contemplated. - The
clip 12 functions as a retaining member and preferably includes twoclip legs patch 20, preferably in opposite directions. Thelegs legs FIG. 14 ) to help retain theclosure device 10 in position. Preferably theclip legs FIGS. 1 and 3 . Materials other than Nitinol or shape memory are also contemplated. The clip legs can be formed of a single wire or separate wires or material. Theclip legs catheter 50 for delivery as shown inFIG. 5 . Cold saline can be injected during delivery to maintain thelegs distal opening 52 at thedistal end portion 54 ofcatheter 50. Whenlegs delivery tube 50, they are warmed by body temperature and move radially in different (e.g., opposite) directions toward their illustrated memorized curved position as shown for example inFIG. 3 . The extent to which the clip legs return to their memorized position will depend on the thickness and resistance of the tissue. As an alternative to two clip (retention) legs, a single clip leg or more than two clip legs could be provided.FIG. 16 illustrates by way of example four clip legs. In this alternate embodiment, the fourclips legs patch 122. The clip legs in these various embodiments could include penetrating tips to engage and penetrate the tissue or blunt tips to just engage the tissue. Blunt tips, e.g.,tips - The
patch 20 can be composed of a variety of materials, such as PFTE, polyethylene, swine intestinal submucosa, endothelium and/or other native tissues such as vein, artery, umbilical, or pericardium as either an allograft or xenograft. The patch could be coated with a hydrophilic, heparin, anti-platelet or anti-thrombogenic coating. Thepatch 20 is in the collapsed configuration withincatheter 50 for delivery as shown inFIG. 5 or further rolled as inFIG. 7 ; it is expanded by thewire 30 to the configuration ofFIGS. 1-3 . - The
wire 30 is preferably composed of shape memory material, such as Nitinol, with an austenitic annular shaped memorized position illustrated inFIGS. 2 and 3 . However, materials other than Nitinol are also contemplated. - When advanced from the
delivery tube 50, thewire 30 is warmed by body temperature and moves from its delivery configuration ofFIG. 5 to its memorized annular configuration withinpatch 20. That is,wire 30 is maintained in a softer martensitic configuration within the catheter or patch to reduce its profile (overall transverse dimension) for delivery. Cold saline can be injected during delivery to maintain thewire 30 in this martensitic condition to facilitate exit from thedistal opening 52 at thedistal end portion 54 ofcatheter 50. In the memorized position, the wire assumes an annular shape along the inside periphery of thepatch 20. As shown it extends more than 360 degrees asportion 32 ofwire 30 overlaps an annular portion of the wire (seeFIG. 3 ). - The embodiment of
FIGS. 7 and 8 differs from the embodiment ofFIGS. 5 and 6 in that the expandingwire 30′ is fed into thepatch 20 in situ. That is, instead of delivering the patch with the wire already inside as inFIGS. 5 and 6 , the wire is advanced into the patch in a separate step after the patch is released to the distal side of the defect. This is explained in detail below in conjunction with the method of placement. - The method of placement of the closure device of the present invention will now be described. The method described is for the embodiment of
FIGS. 7 and 8 where the wire is advanced in situ. Note, in the embodiment ofFIGS. 5 and 6 , thewire 30 is contained within thepatch 20 during delivery so upon ejection of thepatch 20 fromdelivery tube 50, thepatch 20 automatically expands. This avoids the additional step of advancing the wire (the step ofFIG. 12 ). However, it slightly increases the overall delivery profile since the patch cannot collapse to the same degree because of the wire contained therein. In the embodiment ofFIGS. 7 and 8 , thewire 30′ is contained in an elongated substantially straight delivery configuration to provide a smaller profile. - The
delivery catheter 50 is inserted through an introducer sheath in the femoral vein and advanced to access the atria as shown inFIG. 9 . For insertion, thepatch 20,clip 12 andwire 30 are all in the collapsed position. That is, as shown inFIG. 7 , theclip legs wire 30′ is also in a substantially straight position andpatch 20 is collapsed and could be partially rolled. This provides for a reduced profile insertion configuration.FIG. 10 shows a close-up view of the catheter distal end positioned adjacent the septal opening. - In the first step,
pusher 60 is advanced distally, (e.g., by a handle (not shown) or other mechanism) at a proximal end of thecatheter 50 in the direction of arrow F ofFIG. 10 . Distal advancement ofpusher 60 advances the closure device from thecatheter 50 as the distal end 62 ofpusher 60 abutspatch 20. That is, advancement of the pusher in the direction of arrow F ofFIG. 10 advances patch 20 fromcatheter 50 into the right atrium (seeFIG. 11 ) on the distal side D of the defect. Thepatch 20 remains at this point in the collapsed configuration. Once fully ejected, it still remains in an unexpanded configuration. - Next, the wire pusher (not shown) is advanced distally in the direction of arrow E of
FIG. 12 so engagement of the distal end of the wire pusher with theproximal end 31 ofwire 30′ will forcewire 30′ into thepatch 20. As thewire 30′ exits thecatheter 50 and enters thepatch 20 within the right atrium, it is warmed by body temperature and moves toward its shape memorized overlapping annular configuration. This annular configuration expandspatch 20 into a disk shape or a ring shape.FIG. 13 illustrates thepatch 20 in an expanded configuration due to the movement of the wire to its memorized configuration. - Note that in a preferred embodiment, the wire pusher can have a radiopaque marker which can align with the
radiopaque marker 56 on thecatheter 50. This will provide a visual indication to the user that the pusher has completed its travel and thewire 30′ has been inserted as the two markers align and provide a relatively large solid area for imaging. This will occur on full advancement of the wire pusher. A radiopaque marker can also be provided at the base oflegs patch 20 for imaging. Alignment of the radiopaque members is described in application Ser. No. 60/674,321 referenced above. - After full insertion of the
wire 30′ into thepatch 20, thepusher 60 along with thecatheter 50 are withdrawn, releasing theclip legs patch 20 in place to cover the opening to prevent blood flow therethrough. Withdrawal of thecatheter 50 leaves theclosure device 10 in place as shown inFIGS. 13 , 14 and 15. As shown, thepatch 20 will be positioned at the distal side opening to block the opening (defect) in the atrium to prevent blood flow from the left atrium (proximal side) to the right atrium through the defect. - It should be appreciated that in an alternate embodiment, the patch is placed on the proximal side of the defect and the legs are placed on the distal side. This is shown in
FIG. 17 , whereinpatch 220 is placed on the proximal side P of the defect and the retaininglegs - While the above description contains many specifics, those specifics should not be construed as limitations on the scope of the disclosure, but merely as exemplifications of preferred embodiments thereof. For example, the patch could be used to close other openings in the body. Those skilled in the art will envision many other possible variations that are within the scope and spirit of the disclosure as defined by the claims appended hereto.
Claims (16)
1-12. (canceled)
13. A method of closing a septal defect comprising:
providing a covering member for delivery to a distal side of the septal defect, the covering member having a dimension at least equal to a size of the defect to cover the defect;
delivering the covering member in a collapsed position to the distal side of the septal defect, the covering member moving to a an expanded placement configuration to cover the distal side of the defect; and
delivering at least one retaining member in an elongated position to a proximal side of the defect, the retaining member moving to a placement position to engage tissue on the proximal side of the defect to retain the covering member on the distal side of the defect.
14. The method of claim 13 , wherein the step of delivering the covering member occurs prior to movement of the covering member to the expanded placement configuration.
15. The method of claim 13 , wherein the covering member has an expandable wire positioned therein composed of shape memory material so that upon delivery the wire expands to expand the covering member to the placement configuration.
16. The method of claim 15 , wherein the wire is delivered to the covering member is situ.
17. The method of claim 13 , wherein the at least one retaining member is composed of shape memory material so that upon delivery the retaining member automatically moves to a curved placement position.
18. The method of claim 15 , wherein the wire is substantially ring-shaped in a shape memorized position.
19. The method of claim 13 , wherein the at least one retaining member includes two curved legs, and wherein movement to the placement position enables the legs to curve toward the covering member.
20. The method of claim 16 , wherein the wire is delivered in an elongated configuration.
21. The method of claim 20 , wherein the wire moves to a substantially ring-shaped shape memorized position when delivered to the covering member.
22. The method of claim 13 , wherein the at least one retaining member is composed of a different material than the covering member.
23. The method of claim 19 , wherein the legs have free ends and when released from a delivery member to move to a placement position, the free ends curve toward the covering member.
24. The method of claim 13 , wherein a first pusher advances the covering member to the placement configuration.
25. The method of claim 24 , further comprising the step of releasing the first pusher from attachment to the covering member.
26. The method of claim 24 , further comprising the step advancing a wire into the covering member by advancing a second pusher through a lumen in the first pusher.
27. The method of claim 26 , wherein the at least one retaining member is released from a delivery member to move to the placement position after the step of advancing the wire into the covering member.
Applications Claiming Priority (8)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US15373699P | 1999-09-13 | 1999-09-13 | |
US65964800A | 2000-09-12 | 2000-09-12 | |
US35552602P | 2002-02-06 | 2002-02-06 | |
US10/163,142 US7341595B2 (en) | 1999-09-13 | 2002-06-05 | Vascular hole closure device |
US10/345,533 US7267679B2 (en) | 1999-09-13 | 2003-01-16 | Vascular hole closure device |
US10/847,141 US7662161B2 (en) | 1999-09-13 | 2004-05-17 | Vascular hole closure device |
US70360105P | 2005-07-29 | 2005-07-29 | |
US11/482,317 US8083766B2 (en) | 1999-09-13 | 2006-07-07 | Septal defect closure device |
Related Parent Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US11/482,317 Division US8083766B2 (en) | 1999-09-13 | 2006-07-07 | Septal defect closure device |
Publications (1)
Publication Number | Publication Date |
---|---|
US20120065673A1 true US20120065673A1 (en) | 2012-03-15 |
Family
ID=46324769
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US11/482,317 Expired - Fee Related US8083766B2 (en) | 1999-09-13 | 2006-07-07 | Septal defect closure device |
US13/300,866 Abandoned US20120065673A1 (en) | 1999-09-13 | 2011-11-21 | Septal defect closure device |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US11/482,317 Expired - Fee Related US8083766B2 (en) | 1999-09-13 | 2006-07-07 | Septal defect closure device |
Country Status (1)
Country | Link |
---|---|
US (2) | US8083766B2 (en) |
Families Citing this family (25)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8845711B2 (en) | 2007-10-19 | 2014-09-30 | Coherex Medical, Inc. | Medical device for modification of left atrial appendage and related systems and methods |
US9861346B2 (en) | 2003-07-14 | 2018-01-09 | W. L. Gore & Associates, Inc. | Patent foramen ovale (PFO) closure device with linearly elongating petals |
US8784439B1 (en) * | 2006-11-28 | 2014-07-22 | Stephen V. Ward | Percutaneous medical procedures and devices for closing vessels using mechanical closures |
US9005242B2 (en) | 2007-04-05 | 2015-04-14 | W.L. Gore & Associates, Inc. | Septal closure device with centering mechanism |
US20130165967A1 (en) | 2008-03-07 | 2013-06-27 | W.L. Gore & Associates, Inc. | Heart occlusion devices |
US8690911B2 (en) | 2009-01-08 | 2014-04-08 | Coherex Medical, Inc. | Medical device for modification of left atrial appendage and related systems and methods |
US9649115B2 (en) | 2009-06-17 | 2017-05-16 | Coherex Medical, Inc. | Medical device for modification of left atrial appendage and related systems and methods |
US10631969B2 (en) | 2009-06-17 | 2020-04-28 | Coherex Medical, Inc. | Medical device for modification of left atrial appendage and related systems and methods |
US9351716B2 (en) | 2009-06-17 | 2016-05-31 | Coherex Medical, Inc. | Medical device and delivery system for modification of left atrial appendage and methods thereof |
CA2958337C (en) * | 2009-06-17 | 2019-03-19 | Coherex Medical, Inc. | Medical device for modification of left atrial appendage and related systems and methods |
US10064628B2 (en) | 2009-06-17 | 2018-09-04 | Coherex Medical, Inc. | Medical device for modification of left atrial appendage and related systems and methods |
US9636094B2 (en) | 2009-06-22 | 2017-05-02 | W. L. Gore & Associates, Inc. | Sealing device and delivery system |
US20120029556A1 (en) | 2009-06-22 | 2012-02-02 | Masters Steven J | Sealing device and delivery system |
US9381006B2 (en) | 2009-06-22 | 2016-07-05 | W. L. Gore & Associates, Inc. | Sealing device and delivery system |
EP2484310A1 (en) * | 2011-02-08 | 2012-08-08 | Biotronik AG | Heart valve prosthesis with flexible fixations and deployment device therefor |
US20130046339A1 (en) * | 2011-04-28 | 2013-02-21 | Roy K. Greenberg | Fenestration sealing device |
US9770232B2 (en) | 2011-08-12 | 2017-09-26 | W. L. Gore & Associates, Inc. | Heart occlusion devices |
CN104168843B (en) | 2011-11-01 | 2017-03-08 | 科赫里克斯医疗股份有限公司 | For revising the medical treatment device of left auricle and the system and method for correlation |
US20140046347A1 (en) * | 2012-08-10 | 2014-02-13 | W. L. Gore & Associates, Inc. | Devices, systems and methods for engaging tissue |
US10828019B2 (en) | 2013-01-18 | 2020-11-10 | W.L. Gore & Associates, Inc. | Sealing device and delivery system |
US9808230B2 (en) | 2014-06-06 | 2017-11-07 | W. L. Gore & Associates, Inc. | Sealing device and delivery system |
US10603021B2 (en) | 2015-10-02 | 2020-03-31 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Endo-cameral closure device |
US10993807B2 (en) | 2017-11-16 | 2021-05-04 | Medtronic Vascular, Inc. | Systems and methods for percutaneously supporting and manipulating a septal wall |
US11369355B2 (en) | 2019-06-17 | 2022-06-28 | Coherex Medical, Inc. | Medical device and system for occluding a tissue opening and method thereof |
US11812969B2 (en) | 2020-12-03 | 2023-11-14 | Coherex Medical, Inc. | Medical device and system for occluding a tissue opening and method thereof |
Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4836204A (en) * | 1987-07-06 | 1989-06-06 | Landymore Roderick W | Method for effecting closure of a perforation in the septum of the heart |
US5108420A (en) * | 1991-02-01 | 1992-04-28 | Temple University | Aperture occlusion device |
US5634936A (en) * | 1995-02-06 | 1997-06-03 | Scimed Life Systems, Inc. | Device for closing a septal defect |
US5861003A (en) * | 1996-10-23 | 1999-01-19 | The Cleveland Clinic Foundation | Apparatus and method for occluding a defect or aperture within body surface |
US5976174A (en) * | 1997-12-15 | 1999-11-02 | Ruiz; Carlos E. | Medical hole closure device and methods of use |
US6206907B1 (en) * | 1999-05-07 | 2001-03-27 | Cardia, Inc. | Occlusion device with stranded wire support arms |
US20040143294A1 (en) * | 2003-01-22 | 2004-07-22 | Cardia, Inc. | Septal stabilization device |
Family Cites Families (183)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2024871A (en) | 1935-06-13 | 1935-12-17 | Edwin R Parsons | Toggle bolt and sleeve |
US2398220A (en) | 1944-11-28 | 1946-04-09 | Rawlplug Company Inc | Toggle lock |
US3527223A (en) | 1967-09-01 | 1970-09-08 | Melvin Shein | Ear stud and hollow piercer for insertion thereof |
US3874388A (en) | 1973-02-12 | 1975-04-01 | Ochsner Med Found Alton | Shunt defect closure system |
FI50042C (en) | 1973-03-19 | 1975-12-10 | Outokumpu Oy | Interuteral contraceptive body |
JPS5320957Y2 (en) | 1973-11-14 | 1978-06-01 | ||
JPS5719226B2 (en) * | 1974-06-21 | 1982-04-21 | ||
US4007743A (en) | 1975-10-20 | 1977-02-15 | American Hospital Supply Corporation | Opening mechanism for umbrella-like intravascular shunt defect closure device |
US4031569A (en) | 1976-03-15 | 1977-06-28 | Jacob H John | Nasal septum plug |
US4117838A (en) | 1976-09-02 | 1978-10-03 | Hasson Harrith M | Intrauterine contraceptive device |
US4286497A (en) | 1979-06-18 | 1981-09-01 | Shamah Alfred A | Ratchet-securable toggle retainer |
US4317445A (en) | 1980-03-31 | 1982-03-02 | Baxter Travenol Laboratories, Inc. | Catheter insertion unit with separate flashback indication for the cannula |
US4505274A (en) | 1980-10-17 | 1985-03-19 | Propper Manufacturing Co., Inc. | Suture clip |
US4485816A (en) | 1981-06-25 | 1984-12-04 | Alchemia | Shape-memory surgical staple apparatus and method for use in surgical suturing |
US4638803A (en) * | 1982-09-30 | 1987-01-27 | Rand Robert W | Medical apparatus for inducing scar tissue formation in a body |
US4512338A (en) | 1983-01-25 | 1985-04-23 | Balko Alexander B | Process for restoring patency to body vessels |
US4676245A (en) | 1983-02-09 | 1987-06-30 | Mamoru Fukuda | Interlocking surgical staple assembly |
US4665906A (en) | 1983-10-14 | 1987-05-19 | Raychem Corporation | Medical devices incorporating sim alloy elements |
US4615514A (en) | 1985-01-29 | 1986-10-07 | Hamlin Jerry J | Holding apparatus and method for securely positioning members to be joined by welding or the like |
US4610671A (en) | 1985-03-28 | 1986-09-09 | Luther Medical Products, Inc. | Assembly of stylet and catheter |
US4744364A (en) | 1987-02-17 | 1988-05-17 | Intravascular Surgical Instruments, Inc. | Device for sealing percutaneous puncture in a vessel |
USRE34866E (en) | 1987-02-17 | 1995-02-21 | Kensey Nash Corporation | Device for sealing percutaneous puncture in a vessel |
US5478353A (en) | 1987-05-14 | 1995-12-26 | Yoon; Inbae | Suture tie device system and method for suturing anatomical tissue proximate an opening |
US4917089A (en) | 1988-08-29 | 1990-04-17 | Sideris Eleftherios B | Buttoned device for the transvenous occlusion of intracardiac defects |
US5047047A (en) | 1988-10-26 | 1991-09-10 | Inbae Yoon | Wound closing device |
US4924866A (en) | 1988-10-26 | 1990-05-15 | Inbae Yoon | Wound-closing device |
FR2641692A1 (en) | 1989-01-17 | 1990-07-20 | Nippon Zeon Co | Plug for closing an opening for a medical application, and device for the closure plug making use thereof |
NL8901350A (en) | 1989-05-29 | 1990-12-17 | Wouter Matthijs Muijs Van De M | CLOSURE ASSEMBLY. |
US5620461A (en) | 1989-05-29 | 1997-04-15 | Muijs Van De Moer; Wouter M. | Sealing device |
US4971068A (en) | 1989-07-07 | 1990-11-20 | Bio-Plexus, Inc. | Blood vessel locating needle assembly with thermochromic indicator |
US5749879A (en) | 1989-08-16 | 1998-05-12 | Medtronic, Inc. | Device or apparatus for manipulating matter |
US5129906A (en) | 1989-09-08 | 1992-07-14 | Linvatec Corporation | Bioabsorbable tack for joining bodily tissue and in vivo method and apparatus for deploying same |
CA2122041A1 (en) | 1989-12-04 | 1993-04-29 | Kenneth Kensey | Plug device for sealing openings and method of use |
US5061274A (en) | 1989-12-04 | 1991-10-29 | Kensey Nash Corporation | Plug device for sealing openings and method of use |
US5171259A (en) | 1990-04-02 | 1992-12-15 | Kanji Inoue | Device for nonoperatively occluding a defect |
US5021059A (en) | 1990-05-07 | 1991-06-04 | Kensey Nash Corporation | Plug device with pulley for sealing punctures in tissue and methods of use |
US5391183A (en) | 1990-09-21 | 1995-02-21 | Datascope Investment Corp | Device and method sealing puncture wounds |
US5108421A (en) | 1990-10-01 | 1992-04-28 | Quinton Instrument Company | Insertion assembly and method of inserting a vessel plug into the body of a patient |
US5192300A (en) | 1990-10-01 | 1993-03-09 | Quinton Instrument Company | Insertion assembly and method of inserting a vessel plug into the body of a patient |
US5171252A (en) | 1991-02-05 | 1992-12-15 | Friedland Thomas W | Surgical fastening clip formed of a shape memory alloy, a method of making such a clip and a method of using such a clip |
CA2078530A1 (en) | 1991-09-23 | 1993-03-24 | Jay Erlebacher | Percutaneous arterial puncture seal device and insertion tool therefore |
US5350400A (en) | 1991-10-30 | 1994-09-27 | American Cyanamid Company | Malleable, bioabsorbable, plastic staple; and method and apparatus for deforming such staple |
DE69226841T2 (en) | 1991-11-05 | 1999-05-20 | Childrens Medical Center | Occlusion device for repairing heart and vascular defects |
EP0545091B1 (en) | 1991-11-05 | 1999-07-07 | The Children's Medical Center Corporation | Occluder for repair of cardiac and vascular defects |
US5676689A (en) | 1991-11-08 | 1997-10-14 | Kensey Nash Corporation | Hemostatic puncture closure system including vessel location device and method of use |
US5282827A (en) | 1991-11-08 | 1994-02-01 | Kensey Nash Corporation | Hemostatic puncture closure system and method of use |
US5222974A (en) | 1991-11-08 | 1993-06-29 | Kensey Nash Corporation | Hemostatic puncture closure system and method of use |
US5411520A (en) | 1991-11-08 | 1995-05-02 | Kensey Nash Corporation | Hemostatic vessel puncture closure system utilizing a plug located within the puncture tract spaced from the vessel, and method of use |
US5279572A (en) | 1991-12-03 | 1994-01-18 | Yasuo Hokama | Indwelling intravenous needle with two blood-backflow passage routes |
US6056768A (en) | 1992-01-07 | 2000-05-02 | Cates; Christopher U. | Blood vessel sealing system |
JP3393383B2 (en) | 1992-01-21 | 2003-04-07 | リージェンツ オブ ザ ユニバーシティ オブ ミネソタ | Septal defect closure device |
US5236440A (en) | 1992-04-14 | 1993-08-17 | American Cyanamid Company | Surgical fastener |
US6063085A (en) | 1992-04-23 | 2000-05-16 | Scimed Life Systems, Inc. | Apparatus and method for sealing vascular punctures |
US5540712A (en) | 1992-05-01 | 1996-07-30 | Nitinol Medical Technologies, Inc. | Stent and method and apparatus for forming and delivering the same |
US6350274B1 (en) | 1992-05-11 | 2002-02-26 | Regen Biologics, Inc. | Soft tissue closure systems |
US5413571A (en) | 1992-07-16 | 1995-05-09 | Sherwood Medical Company | Device for sealing hemostatic incisions |
US5443481A (en) | 1992-07-27 | 1995-08-22 | Lee; Benjamin I. | Methods and device for percutaneous sealing of arterial puncture sites |
US5306254A (en) | 1992-10-01 | 1994-04-26 | Kensey Nash Corporation | Vessel position locating device and method of use |
US5643317A (en) | 1992-11-25 | 1997-07-01 | William Cook Europe S.A. | Closure prosthesis for transcatheter placement |
US5267971A (en) | 1993-03-17 | 1993-12-07 | Becton, Dickinson And Company | Catheter introducer with notched needle |
US5334210A (en) * | 1993-04-09 | 1994-08-02 | Cook Incorporated | Vascular occlusion assembly |
US5312435A (en) | 1993-05-17 | 1994-05-17 | Kensey Nash Corporation | Fail predictable, reinforced anchor for hemostatic puncture closure |
AU7099994A (en) | 1993-06-04 | 1995-01-03 | Kensey Nash Corporation | Hemostatic vessel puncture closure with filament lock |
US5486195A (en) | 1993-07-26 | 1996-01-23 | Myers; Gene | Method and apparatus for arteriotomy closure |
US5462561A (en) | 1993-08-05 | 1995-10-31 | Voda; Jan K. | Suture device |
FR2710254B1 (en) | 1993-09-21 | 1995-10-27 | Mai Christian | Multi-branch osteosynthesis clip with self-retaining dynamic compression. |
US5531759A (en) | 1994-04-29 | 1996-07-02 | Kensey Nash Corporation | System for closing a percutaneous puncture formed by a trocar to prevent tissue at the puncture from herniating |
US5545178A (en) | 1994-04-29 | 1996-08-13 | Kensey Nash Corporation | System for closing a percutaneous puncture formed by a trocar to prevent tissue at the puncture from herniating |
US5725552A (en) | 1994-07-08 | 1998-03-10 | Aga Medical Corporation | Percutaneous catheter directed intravascular occlusion devices |
US5846261A (en) | 1994-07-08 | 1998-12-08 | Aga Medical Corp. | Percutaneous catheter directed occlusion devices |
US5549633A (en) | 1994-08-24 | 1996-08-27 | Kensey Nash Corporation | Apparatus and methods of use for preventing blood seepage at a percutaneous puncture site |
US6171329B1 (en) | 1994-12-19 | 2001-01-09 | Gore Enterprise Holdings, Inc. | Self-expanding defect closure device and method of making and using |
US5879366A (en) | 1996-12-20 | 1999-03-09 | W.L. Gore & Associates, Inc. | Self-expanding defect closure device and method of making and using |
US5702421A (en) | 1995-01-11 | 1997-12-30 | Schneidt; Bernhard | Closure device for closing a vascular opening, such as patent ductus arteriosus |
US5649959A (en) | 1995-02-10 | 1997-07-22 | Sherwood Medical Company | Assembly for sealing a puncture in a vessel |
US5976159A (en) | 1995-02-24 | 1999-11-02 | Heartport, Inc. | Surgical clips and methods for tissue approximation |
US5810846A (en) | 1995-08-03 | 1998-09-22 | United States Surgical Corporation | Vascular hole closure |
US6071300A (en) | 1995-09-15 | 2000-06-06 | Sub-Q Inc. | Apparatus and method for percutaneous sealing of blood vessel punctures |
US5674231A (en) | 1995-10-20 | 1997-10-07 | United States Surgical Corporation | Apparatus and method for vascular hole closure |
DE69612507T2 (en) | 1995-10-30 | 2001-08-09 | Childrens Medical Center | SELF-CENTERING, SHIELD-LIKE DEVICE FOR CLOSING A SEPTAL DEFECT |
US6015417A (en) | 1996-01-25 | 2000-01-18 | Reynolds, Jr.; Walker | Surgical fastener |
DE19604817C2 (en) | 1996-02-09 | 2003-06-12 | Pfm Prod Fuer Die Med Ag | Device for closing defect openings in the human or animal body |
US5853422A (en) | 1996-03-22 | 1998-12-29 | Scimed Life Systems, Inc. | Apparatus and method for closing a septal defect |
US5728132A (en) | 1996-04-08 | 1998-03-17 | Tricardia, L.L.C. | Self-sealing vascular access device |
AR001590A1 (en) * | 1996-04-10 | 1997-11-26 | Jorge Alberto Baccaro | Abnormal vascular communications occluder device and applicator cartridge of said device |
US5662681A (en) | 1996-04-23 | 1997-09-02 | Kensey Nash Corporation | Self locking closure for sealing percutaneous punctures |
EP0900051A1 (en) | 1996-05-08 | 1999-03-10 | Salviac Limited | An occluder device |
US5893856A (en) | 1996-06-12 | 1999-04-13 | Mitek Surgical Products, Inc. | Apparatus and method for binding a first layer of material to a second layer of material |
US5690674A (en) | 1996-07-02 | 1997-11-25 | Cordis Corporation | Wound closure with plug |
US5728133A (en) | 1996-07-09 | 1998-03-17 | Cardiologics, L.L.C. | Anchoring device and method for sealing percutaneous punctures in vessels |
RU2108070C1 (en) | 1996-07-09 | 1998-04-10 | Борис Петрович Кручинин | Microsurgical fastening device and manipulation pusher for its mounting |
US5669933A (en) | 1996-07-17 | 1997-09-23 | Nitinol Medical Technologies, Inc. | Removable embolus blood clot filter |
ATE375758T1 (en) | 1996-08-06 | 2007-11-15 | St Jude Med Puerto Rico Bv | INTRODUCTION DEVICE FOR INSERTING A HEMOSTATIC OCCLUSION INTO AN INCISION |
US5896856A (en) * | 1996-08-14 | 1999-04-27 | Frasier; Robert J. | Emergency air cooling device |
US5741297A (en) | 1996-08-28 | 1998-04-21 | Simon; Morris | Daisy occluder and method for septal defect repair |
US5810884A (en) | 1996-09-09 | 1998-09-22 | Beth Israel Deaconess Medical Center | Apparatus and method for closing a vascular perforation after percutaneous puncture of a blood vessel in a living subject |
US5782861A (en) | 1996-12-23 | 1998-07-21 | Sub Q Inc. | Percutaneous hemostasis device |
IL119911A (en) | 1996-12-25 | 2001-03-19 | Niti Alloys Tech Ltd | Surgical clip |
US5776162A (en) | 1997-01-03 | 1998-07-07 | Nitinol Medical Technologies, Inc. | Vessel implantable shape memory appliance with superelastic hinged joint |
US5782860A (en) | 1997-02-11 | 1998-07-21 | Biointerventional Corporation | Closure device for percutaneous occlusion of puncture sites and tracts in the human body and method |
US6258120B1 (en) | 1997-12-23 | 2001-07-10 | Embol-X, Inc. | Implantable cerebral protection device and methods of use |
US6409739B1 (en) | 1997-05-19 | 2002-06-25 | Cardio Medical Solutions, Inc. | Device and method for assisting end-to side anastomosis |
US6001110A (en) | 1997-06-20 | 1999-12-14 | Boston Scientific Corporation | Hemostatic clips |
GB9715241D0 (en) * | 1997-07-18 | 1997-09-24 | Jeffree Martin A | Device for treating aneurysms |
AU8772198A (en) * | 1997-08-05 | 1999-03-08 | Target Therapeutics, Inc. | Detachable aneurysm neck bridge |
US6174322B1 (en) | 1997-08-08 | 2001-01-16 | Cardia, Inc. | Occlusion device for the closure of a physical anomaly such as a vascular aperture or an aperture in a septum |
US5916235A (en) * | 1997-08-13 | 1999-06-29 | The Regents Of The University Of California | Apparatus and method for the use of detachable coils in vascular aneurysms and body cavities |
FR2768324B1 (en) | 1997-09-12 | 1999-12-10 | Jacques Seguin | SURGICAL INSTRUMENT FOR PERCUTANEOUSLY FIXING TWO AREAS OF SOFT TISSUE, NORMALLY MUTUALLY REMOTE, TO ONE ANOTHER |
US5964782A (en) | 1997-09-18 | 1999-10-12 | Scimed Life Systems, Inc. | Closure device and method |
US5984949A (en) | 1997-10-06 | 1999-11-16 | Levin; John M. | Tissue hooks and tools for applying same |
US6033427A (en) | 1998-01-07 | 2000-03-07 | Lee; Benjamin I. | Method and device for percutaneous sealing of internal puncture sites |
US5944738A (en) | 1998-02-06 | 1999-08-31 | Aga Medical Corporation | Percutaneous catheter directed constricting occlusion device |
US6113611A (en) | 1998-05-28 | 2000-09-05 | Advanced Vascular Technologies, Llc | Surgical fastener and delivery system |
US5919207A (en) | 1998-06-02 | 1999-07-06 | Taheri; Syde A. | Percutaneous arterial closure with staples |
US5910155A (en) | 1998-06-05 | 1999-06-08 | United States Surgical Corporation | Vascular wound closure system |
US6250308B1 (en) | 1998-06-16 | 2001-06-26 | Cardiac Concepts, Inc. | Mitral valve annuloplasty ring and method of implanting |
US6139564A (en) | 1998-06-16 | 2000-10-31 | Target Therapeutics Inc. | Minimally occlusive flow disruptor stent for bridging aneurysm necks |
US6048357A (en) | 1998-07-09 | 2000-04-11 | X-Site, L.L.C. | Anchoring device and method for sealing punctures in vessels |
US6048358A (en) | 1998-07-13 | 2000-04-11 | Barak; Shlomo | Method and apparatus for hemostasis following arterial catheterization |
US6334865B1 (en) | 1998-08-04 | 2002-01-01 | Fusion Medical Technologies, Inc. | Percutaneous tissue track closure assembly and method |
US6336941B1 (en) * | 1998-08-14 | 2002-01-08 | G. V. Subba Rao | Modular hip implant with shock absorption system |
US6007558A (en) | 1998-09-25 | 1999-12-28 | Nitinol Medical Technologies, Inc. | Removable embolus blood clot filter |
US6183496B1 (en) | 1998-11-02 | 2001-02-06 | Datascope Investment Corp. | Collapsible hemostatic plug |
US6080183A (en) | 1998-11-24 | 2000-06-27 | Embol-X, Inc. | Sutureless vessel plug and methods of use |
JP3906475B2 (en) | 1998-12-22 | 2007-04-18 | ニプロ株式会社 | Transcatheter surgery closure plug and catheter assembly |
US6120524A (en) | 1999-02-16 | 2000-09-19 | Taheri; Syde A. | Device for closing an arterial puncture and method |
US6228096B1 (en) | 1999-03-31 | 2001-05-08 | Sam R. Marchand | Instrument and method for manipulating an operating member coupled to suture material while maintaining tension on the suture material |
US6537299B1 (en) | 1999-04-05 | 2003-03-25 | Ethicon, Inc. | Intravascular hemostasis device and method |
US6752813B2 (en) | 1999-04-09 | 2004-06-22 | Evalve, Inc. | Methods and devices for capturing and fixing leaflets in valve repair |
US6231602B1 (en) | 1999-04-16 | 2001-05-15 | Edwards Lifesciences Corporation | Aortic annuloplasty ring |
US6187040B1 (en) | 1999-05-03 | 2001-02-13 | John T. M. Wright | Mitral and tricuspid annuloplasty rings |
US6712836B1 (en) | 1999-05-13 | 2004-03-30 | St. Jude Medical Atg, Inc. | Apparatus and methods for closing septal defects and occluding blood flow |
AU5160500A (en) | 1999-05-28 | 2000-12-18 | Cohesion Technologies, Inc. | Apparatuses, methods and compositions for closing tissue puncture openings |
US6766186B1 (en) | 1999-06-16 | 2004-07-20 | C. R. Bard, Inc. | Post biospy tissue marker and method of use |
US6251122B1 (en) | 1999-09-02 | 2001-06-26 | Scimed Life Systems, Inc. | Intravascular filter retrieval device and method |
AU5812299A (en) | 1999-09-07 | 2001-04-10 | Microvena Corporation | Retrievable septal defect closure device |
US7662161B2 (en) | 1999-09-13 | 2010-02-16 | Rex Medical, L.P | Vascular hole closure device |
US7942888B2 (en) | 1999-09-13 | 2011-05-17 | Rex Medical, L.P. | Vascular hole closure device |
US6231561B1 (en) | 1999-09-20 | 2001-05-15 | Appriva Medical, Inc. | Method and apparatus for closing a body lumen |
US6331184B1 (en) * | 1999-12-10 | 2001-12-18 | Scimed Life Systems, Inc. | Detachable covering for an implantable medical device |
US6391048B1 (en) | 2000-01-05 | 2002-05-21 | Integrated Vascular Systems, Inc. | Integrated vascular device with puncture site closure component and sealant and methods of use |
US6197042B1 (en) | 2000-01-05 | 2001-03-06 | Medical Technology Group, Inc. | Vascular sheath with puncture site closure apparatus and methods of use |
US6336914B1 (en) | 2000-01-13 | 2002-01-08 | Gillespie, Iii Richard D. | Releasable interlock assembly having axial and rotational engagement |
US6350270B1 (en) * | 2000-01-24 | 2002-02-26 | Scimed Life Systems, Inc. | Aneurysm liner |
US6391037B1 (en) * | 2000-03-02 | 2002-05-21 | Prodesco, Inc. | Bag for use in the intravascular treatment of saccular aneurysms |
US6346117B1 (en) * | 2000-03-02 | 2002-02-12 | Prodesco, Inc. | Bag for use in the intravascular treatment of saccular aneurysms |
JP3844661B2 (en) | 2000-04-19 | 2006-11-15 | ラディ・メディカル・システムズ・アクチェボラーグ | Intra-arterial embolus |
US6214029B1 (en) | 2000-04-26 | 2001-04-10 | Microvena Corporation | Septal defect occluder |
US6551344B2 (en) | 2000-04-26 | 2003-04-22 | Ev3 Inc. | Septal defect occluder |
US7153323B1 (en) * | 2000-06-30 | 2006-12-26 | Boston Scientific Scimed, Inc. | Aneurysm liner with multi-segment extender |
WO2002005865A2 (en) | 2000-07-14 | 2002-01-24 | Sub-Q, Inc. | Sheath-mounted arterial plug delivery device |
US6440152B1 (en) | 2000-07-28 | 2002-08-27 | Microvena Corporation | Defect occluder release assembly and method |
US6447524B1 (en) | 2000-10-19 | 2002-09-10 | Ethicon Endo-Surgery, Inc. | Fastener for hernia mesh fixation |
US6645225B1 (en) | 2000-11-01 | 2003-11-11 | Alvan W. Atkinson | Method and apparatus for plugging a patent foramen ovale formed in the heart |
US6508828B1 (en) | 2000-11-03 | 2003-01-21 | Radi Medical Systems Ab | Sealing device and wound closure device |
US6626937B1 (en) | 2000-11-14 | 2003-09-30 | Advanced Cardiovascular Systems, Inc. | Austenitic nitinol medical devices |
US20020082622A1 (en) | 2000-11-24 | 2002-06-27 | Kane David Lee | Collapsed deployable soft tissue anchor for repairing soft tissue to bone |
US6695867B2 (en) | 2002-02-21 | 2004-02-24 | Integrated Vascular Systems, Inc. | Plunger apparatus and methods for delivering a closure device |
DE60205780T2 (en) | 2001-01-12 | 2006-05-18 | Radi Medical Systems Ab | Arterial wall occlusion device provided with a position indicator |
US6569185B2 (en) | 2001-02-15 | 2003-05-27 | Scimed Life Systems Inc | Continuous infusion technique for arterial sealing |
US7025776B1 (en) | 2001-04-24 | 2006-04-11 | Advanced Catheter Engineering, Inc. | Arteriotomy closure devices and techniques |
US6855153B2 (en) * | 2001-05-01 | 2005-02-15 | Vahid Saadat | Embolic balloon |
JP4267867B2 (en) | 2001-05-03 | 2009-05-27 | ラディ・メディカル・システムズ・アクチェボラーグ | Wound occlusion element guide device |
ATE272359T1 (en) | 2001-05-09 | 2004-08-15 | Radi Medical Systems | DEVICE FOR SEALING AN ARTERIAL PERFORATION |
US6863680B2 (en) | 2001-11-08 | 2005-03-08 | Sub-Q, Inc. | System and method for delivering hemostasis promoting material to a blood vessel puncture site by fluid pressure |
CA2448900C (en) | 2001-06-08 | 2011-05-17 | Morris Innovative Research, Inc. | Method and apparatus for sealing access |
US6811560B2 (en) * | 2001-09-20 | 2004-11-02 | Cordis Neurovascular, Inc. | Stent aneurysm embolization method and device |
US20030105487A1 (en) | 2001-11-30 | 2003-06-05 | Benz Philip David | Hemostatic compression pad |
US8430934B2 (en) | 2002-03-01 | 2013-04-30 | Regents Of The University Of Minnesota | Vascular occlusion device |
US7695488B2 (en) * | 2002-03-27 | 2010-04-13 | Boston Scientific Scimed, Inc. | Expandable body cavity liner device |
US7033393B2 (en) | 2002-06-27 | 2006-04-25 | Raymedica, Inc. | Self-transitioning spinal disc anulus occulsion device and method of use |
EP1526810B1 (en) | 2002-07-31 | 2009-04-15 | Abbott Laboratories Vascular Enterprises Limited | Apparatus for sealing surgical punctures |
DE60331740D1 (en) | 2002-08-01 | 2010-04-29 | Abbott Lab Vascular Entpr Ltd | DEVICE FOR SEALING POINTING POINTS IN BLOOD VESSELS |
US6960224B2 (en) | 2003-01-22 | 2005-11-01 | Cardia, Inc. | Laminated sheets for use in a fully retrievable occlusion device |
WO2004112864A2 (en) | 2003-06-19 | 2004-12-29 | Vascular Therapies Llc | Medical devices and methods for regulating the tissue response to vascular closure devices |
ES2428967T3 (en) | 2003-07-14 | 2013-11-12 | W.L. Gore & Associates, Inc. | Oval foramen tubular permeable closure device (FOP) with retention system |
US7144410B2 (en) | 2003-09-18 | 2006-12-05 | Cardia Inc. | ASD closure device with self centering arm network |
US20050192627A1 (en) | 2003-10-10 | 2005-09-01 | Whisenant Brian K. | Patent foramen ovale closure devices, delivery apparatus and related methods and systems |
US8337522B2 (en) | 2003-10-15 | 2012-12-25 | St. Jude Medical Puerto Rico Llc | Vascular sealing device with locking hub |
US7326230B2 (en) | 2003-10-23 | 2008-02-05 | Sundaram Ravikumar | Vascular sealing device and method of use |
US7175648B2 (en) | 2003-11-18 | 2007-02-13 | Granit Medical Innovations, Llc | Deep endoscopic staple and stapler |
US20050267524A1 (en) | 2004-04-09 | 2005-12-01 | Nmt Medical, Inc. | Split ends closure device |
JP4418785B2 (en) | 2004-09-29 | 2010-02-24 | テルモ株式会社 | Patent application for patent foramen ovale and instrument for patent foramen ovale |
-
2006
- 2006-07-07 US US11/482,317 patent/US8083766B2/en not_active Expired - Fee Related
-
2011
- 2011-11-21 US US13/300,866 patent/US20120065673A1/en not_active Abandoned
Patent Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4836204A (en) * | 1987-07-06 | 1989-06-06 | Landymore Roderick W | Method for effecting closure of a perforation in the septum of the heart |
US5108420A (en) * | 1991-02-01 | 1992-04-28 | Temple University | Aperture occlusion device |
US5634936A (en) * | 1995-02-06 | 1997-06-03 | Scimed Life Systems, Inc. | Device for closing a septal defect |
US5861003A (en) * | 1996-10-23 | 1999-01-19 | The Cleveland Clinic Foundation | Apparatus and method for occluding a defect or aperture within body surface |
US5976174A (en) * | 1997-12-15 | 1999-11-02 | Ruiz; Carlos E. | Medical hole closure device and methods of use |
US6206907B1 (en) * | 1999-05-07 | 2001-03-27 | Cardia, Inc. | Occlusion device with stranded wire support arms |
US20040143294A1 (en) * | 2003-01-22 | 2004-07-22 | Cardia, Inc. | Septal stabilization device |
Also Published As
Publication number | Publication date |
---|---|
US20060276839A1 (en) | 2006-12-07 |
US8083766B2 (en) | 2011-12-27 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
US8083766B2 (en) | Septal defect closure device | |
US10143458B2 (en) | Intracardiac cage and method of delivering same | |
US9901350B2 (en) | Closure device for left atrial appendage | |
US6746426B1 (en) | Transluminally deliverable vascular blockers and methods for facilitating retrograde flow of arterial blood through veins | |
KR101034170B1 (en) | Percutaneous catheter directed intravascular occlusion devices | |
US6436088B2 (en) | Method and apparatus for closing a subcutaneous tissue opening | |
US20090099596A1 (en) | Closure device for left atrial appendage | |
US11540835B2 (en) | Method and system for closing left atrial appendage | |
US20140371789A1 (en) | Minimally invasive surgical techniques | |
US20120022427A1 (en) | Method for increasing blood flow in or about a cardiac or other vascular or prosthetic structure to prevent thrombosis | |
US20070083232A1 (en) | Vascular closure device | |
US20010041914A1 (en) | Tissue patch deployment catheter | |
JP2013536036A (en) | Minimally invasive surgery technology |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
STCB | Information on status: application discontinuation |
Free format text: ABANDONED -- FAILURE TO RESPOND TO AN OFFICE ACTION |