US20100185234A1 - Closure devices, systems, and methods - Google Patents

Closure devices, systems, and methods Download PDF

Info

Publication number
US20100185234A1
US20100185234A1 US12/688,065 US68806510A US2010185234A1 US 20100185234 A1 US20100185234 A1 US 20100185234A1 US 68806510 A US68806510 A US 68806510A US 2010185234 A1 US2010185234 A1 US 2010185234A1
Authority
US
United States
Prior art keywords
closure device
disposed
elongate
elongate member
anchor
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
US12/688,065
Inventor
Aaron M. Fortson
Wouter E. Roorda
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Abbott Vascular Inc
Original Assignee
Abbott Vascular Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbott Vascular Inc filed Critical Abbott Vascular Inc
Priority to US12/688,065 priority Critical patent/US20100185234A1/en
Publication of US20100185234A1 publication Critical patent/US20100185234A1/en
Priority to US14/323,753 priority patent/US9414824B2/en
Assigned to ABBOTT VASCULAR INC reassignment ABBOTT VASCULAR INC ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: FORTSON, AARON M., ROORDA, WOUTER E.
Abandoned legal-status Critical Current

Links

Images

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/0057Implements for plugging an opening in the wall of a hollow or tubular organ, e.g. for sealing a vessel puncture or closing a cardiac septal defect
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/0057Implements for plugging an opening in the wall of a hollow or tubular organ, e.g. for sealing a vessel puncture or closing a cardiac septal defect
    • A61B2017/00646Type of implements
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/0057Implements for plugging an opening in the wall of a hollow or tubular organ, e.g. for sealing a vessel puncture or closing a cardiac septal defect
    • A61B2017/00646Type of implements
    • A61B2017/00654Type of implements entirely comprised between the two sides of the opening

Definitions

  • the present disclosure relates generally to medical devices, systems, and methods.
  • the present disclosure relates to vessel closure devices, systems, and methods.
  • Catheterization and interventional procedures such as angioplasty or stenting, generally are performed by inserting a hollow needle through a patient's skin and tissue into the patient's vascular system.
  • a guidewire may be advanced through the needle and into the patient's blood vessel accessed by the needle.
  • the needle is then removed, enabling an introducer sheath to be advanced over the guidewire into the vessel, e.g., in conjunction with or subsequent to a dilator.
  • a catheter or other device may then be advanced through a lumen of the introducer sheath and over the guidewire into a position for performing a medical procedure.
  • the introducer sheath may facilitate introducing various devices into the vessel, while minimizing trauma to the vessel wall and/or minimizing blood loss during a procedure.
  • the devices and introducer sheath are removed, leaving a puncture site in the vessel wall.
  • external pressure is applied to the puncture site until clotting and wound sealing occur; however, the patient must remain bedridden for a substantial period after clotting to ensure closure of the wound.
  • This procedure may be time consuming and expensive, requiring as much as an hour of a physician's or nurse's time. It is also uncomfortable for the patient and requires that the patient remain immobilized in the operating room, catheter lab, or holding area. In addition, a risk of hematoma exists from bleeding before hemostasis occurs.
  • the present disclosure includes vessel closure devices, systems, and methods.
  • the devices, systems, and methods of the present disclosure may allow a medical service provider to efficiently and quickly close an opening in a body lumen in a cost effective manner.
  • the devices, systems, and methods of the present disclosure may allow for the closing of smaller body lumen openings using fewer parts than prior devices and systems.
  • a closure device configured to close an opening in a body lumen may include an elongate member having a distal end and a proximal end.
  • an anchor member may be disposed on the elongate member proximate the distal end of the elongate member.
  • a cap member may also be disposed on the elongate member a distance from the distal end of the elongate member.
  • FIG. 1 illustrates an example closure device for closing an opening in a body lumen or other tissue
  • FIG. 2 illustrates an another example closure device for closing an opening in a body lumen or other tissue
  • FIG. 3A illustrates an example closure system for closing an opening in a body lumen or other tissue
  • FIG. 3B illustrates an additional example closure system
  • FIG. 3C illustrates a further example closure system
  • FIGS. 4-11 illustrate an example method of closing a lumen opening.
  • an example closure system may allow for at least one of reduced production costs, ease of use, and more effective hemostasis.
  • embodiments of the closure system disclosed herein may allow for the closure of smaller openings in body lumens or other tissue.
  • the closure system may include a closure device.
  • the closure device may include an elongate member, such as a suture or shaft, an anchor member (or foot), and a cap member.
  • the closure device may be disposed within or deployed by the closure system.
  • the closure system may include an outer member, an inner member, an intermediate member, or combinations thereof configured to deploy a closure device from the closure system.
  • the closure device 100 may include a plurality of closure members 110 coupled to an elongate member 120 .
  • the plurality of closure members 110 may include an anchor member 110 a and/or a cap member 110 b .
  • the anchor member 110 a may be disposed near a distal end of the elongate member 120 .
  • the cap member 110 b may be proximate the anchor member 110 a and/or spaced a distance away from the distal end of the elongate member 120 .
  • the anchor member 110 a may be configured to be deployed through an opening in a body lumen in order to secure the closure device 100 from a point distal to the lumen opening.
  • the anchor member 110 a may be configured to move from a compressed, folded, or compacted first position having a dimension smaller than a lumen opening to a deployed, unfolded, or expanded second position having a dimension larger than the lumen opening.
  • the anchor member 110 a may pass through the lumen opening while in the first position and thereafter may move to the second position and provide an anchor against the distal side of the lumen wall proximate the lumen opening.
  • the elongate member 120 may extend proximally from the deployed anchor member 110 a and/or may be tensioned to secure the anchor member 110 a proximate the lumen opening and/or against a distal surface of a lumen wall once deployed.
  • the elongate member 120 may pass through the cap member 110 b , which may be deployed at a position proximal of the lumen wall. Once deployed, the cap member 110 b may be moved in a distal direction and/or may engage the proximal surface of the lumen wall.
  • the anchor member 110 a and/or cap member 110 b may at least partially close the lumen opening.
  • the closure device 100 including, but not limited to, the anchor member 110 a and/or cap member 110 b , may include one or more biocompatible, bioabsorbable, bioresorbable, other materials, or combinations thereof.
  • examples of such materials may include a suitable hydrogel, hydrophilic polymer, biodegradable polymers, bioabsorbable polymers and bioneutral polymers.
  • polymers may include poly(alpha-hydroxy esters), polylactic acids, polylactides, poly-L-lactide, poly-DL-lactide, poly-L-lactide-co-DL-lactide, polyglycolic acids, polyglycolide, polylactic-co-glycolic acids, polyglycolide-co-lactide, polyglycolide-co-DL-lactide, polyglycolide-co-L-lactide, polyanhydrides, polyanhydride-co-imides, polyesters, polyorthoesters, polycaprolactones, polyesters, polyanydrides, polyphosphazenes, polyester amides, polyester urethanes, polycarbonates, polytrimethylene carbonates, polyglycolide-co-trimethylene carbonates, poly(PBA-carbonates), polyfumarates, polypropylene fumarate, poly(p-dioxanone), polyhydroxyalkanoates, polyamino acids, polyamin
  • the closure device 100 including, but not limited to, the anchor member 110 a and/or cap member 110 b , may be coated with an active pharmaceutical ingredient with or without a polymeric carrier.
  • the active pharmaceutical ingredient can be any drug.
  • the pharmaceutical ingredient may increase tissue growth.
  • the polymeric coating and drug may be configured to cooperate so as to form a diffusion pathway (e.g., lipophilic, hydrophilic, and/or amphipathic) with tissue when at least a portion of the closure device 100 engages tissue. This may facilitate diffusion into the tissue instead of into a body fluid passing over the closure device 100 .
  • a diffusion pathway e.g., lipophilic, hydrophilic, and/or amphipathic
  • the closure device 100 or any portion thereof may be loaded with and deliver beneficial agents or drugs, such as therapeutic agents, pharmaceuticals and radiation therapies.
  • the closure device 100 and/or coating material may contain a drug or beneficial agent to improve the use of the closure device 100 .
  • drugs or beneficial agents may include antithrombotics, anticoagulants, antiplatelet agents, thrombolytics, antiproliferatives, anti-inflammatories, hemostatic agents, agents that inhibit hyperplasia, inhibitors of smooth muscle proliferation, antibiotics, growth factor inhibitors, or cell adhesion inhibitors, as well as antineoplastics, antimitotics, antifibrins, antioxidants, agents that promote endothelial cell recovery, antiallergic substances, radiopaque agents, viral vectors having beneficial genes, genes, siRNA, antisense compounds, oligionucleotides, cell permeation enhancers, and combinations thereof.
  • the anchor member 110 a and/or cap member 110 b may include any shape configured to facilitate obstruction of a lumen opening.
  • the anchor member 110 a and/or cap member 110 b may have a disc-like shape.
  • the anchor member 110 a and/or cap member 110 b may include a generally flat piece of material that may be circular or oval in shape.
  • the anchor member 110 a and/or cap member 110 b may incorporate other shapes and/or configurations.
  • the anchor member 110 a and/or cap member 110 b may have an elliptical and/or polygonal shape.
  • the closure members 110 may be rectangular in shape along the length thereof with rounded and/or triangular ends or corners.
  • the thickness of the anchor member 110 a and/or cap member 110 b may be continuous throughout the anchor member 110 a and/or cap member 110 b . In further implementations, however, the thickness of the anchor member 110 a and/or cap member 110 b may vary as desired for a particular application. For example, the thickness of the anchor member 110 a and/or cap member 110 b may be greater near the center than along the outer edge of the anchor member 110 a and/or cap member 110 b . In a yet further example, the thickness of the anchor member 110 a and/or cap member 110 b may be greater along a first axis extending through the center of the anchor member 110 a and/or cap member 110 b and progressively thinner extending away from the first axis.
  • the anchor member 110 a and/or cap member 110 b may allow bending about the first axis but may resist bending about an axis perpendicular to or different from the first axis.
  • the thickness of the anchor member 110 a and/or cap member 110 b may vary as desired to achieve a particular strength, rigidity, flexibility, and/or other mechanical property.
  • the anchor member 110 a and cap member 110 b may have the same shape, size, coating, and/or other characteristics, and/or combinations thereof. In a further embodiment, the shape, size, coating, and/or other characteristics of the anchor member 110 a may be different than those of the cap member 110 b.
  • the closure device 100 may include an elongate member 120 .
  • the anchor member 110 a may be coupled to a distal end of the elongate member 120 and/or the cap member 110 b may be disposed on the elongate member 120 at a position along the length of the elongate member 120 .
  • the elongate member 120 may include one or more bioabsorbable materials and/or beneficial agents, such as any bioabsorbable material and/or beneficial agents disclosed herein.
  • the elongate member 120 may include a bioabsorbable metal, alloy, polymer, plastic, composite, other materials, or combinations thereof.
  • the elongate member 120 may include a single limb, such as disclosed in FIG.
  • the elongate member 120 may include a suture or a plurality of sutures.
  • the elongate member 120 may include an elongate shaft or a plurality of elongate shafts.
  • at least a portion of the elongate member 120 may be generally tubular or hollow.
  • the closure device 100 may be configured to resist proximal movement of the cap member 110 b and/or distal movement of the anchor member 110 a after deployment.
  • a knot may be disposed on the elongate member 120 proximal of the cap member 110 b to secure the cap member 110 b and/or anchor member 110 a in place.
  • a cleat such as a bioabsorbable plastic cleat, may be positioned to secure the cap member 110 b and/or anchor member 110 a in place.
  • the cleat may be positioned along the elongate member 120 proximal of and/or abutting the cap member 110 b .
  • the cleat may maintain sufficient tension in the elongate member 120 to maintain the cap member 110 b and anchor member 110 a securely in a deployed position, such as in apposition with the lumen wall and/or lumen opening therebetween.
  • the anchor member 110 a and cap member 110 b may sandwich the lumen wall surrounding a lumen opening to achieve closure of the lumen opening.
  • the closure device 100 may include a mechanism to lock and/or secure the anchor member 110 a and cap member 110 b in place.
  • the elongate member 120 may have a uniform thickness along its length and/or pass through an aperture in the cap member 110 b configured to produce sufficient frictional force between the cap member 110 b and elongate member 120 to resist relative movement between the elongate member 120 and cap member 110 b .
  • this configuration may allow the cap member 110 b to be deployed by sliding the cap member 110 b in a distal direction along the elongate member 120 to secure the cap member 110 b and anchor member 110 a in place. Once deployed, the frictional force between the elongate member 120 and the cap member 110 b may prevent and/or resist further movement by the cap member 110 b and/or anchor member 110 a.
  • the closure device 100 may include a barbed and/or ratchet design to secure the cap member 110 b and anchor member 110 a in the deployed configuration.
  • the elongate member 120 may include a plurality of projections 125 disposed along the length thereof.
  • the projections 125 may include barbs, teeth, ridges, and/or other similar projections.
  • the projections 125 may be configured to allow the cap member 110 b to move in a distal direction but may resist/prevent movement by the cap member 110 b in a proximal direction.
  • the projections 125 may be angled and/or extend in a distal direction to allow the cap member 110 b to pass over the projections 125 in a distal direction but to prevent the cap member 110 b from then passing back over the projections 125 in a proximal direction. Accordingly, once the anchor member 110 a is deployed and/or secured against the distal surface of the lumen wall, the cap member 110 b may be advanced along the elongate member 120 over the projections 125 . The cap member 110 b may be secured against the proximal surface of the lumen wall and/or held in place by one or more of the projections 125 of the elongate member 120 .
  • the locking mechanism (i.e., knot, cleat, projections, etc.) may be independent of the cap member 110 b .
  • decoupling the locking mechanism from the cap member 110 b may allow for the independent optimization of the locking mechanism and/or the cap member 110 b .
  • the closure device 100 may further include a sliding collet that may be advanced along the elongate member 120 and/or lock the cap member 110 b in place once deployed.
  • the collet may incorporate one or more locking features that may be otherwise incorporated in the cap member 110 b as explained in more detail herein.
  • the cap member 110 b may be secured in place using a hollow elongate member 120 and a plug configured to be inserted into the elongate member 120 .
  • the cap member 110 b may be moved along the hollow elongate member 120 into apposition with the anchor member 110 a , thereby applying pressure to opposite sides of the lumen wall near the lumen opening.
  • a plug may be driven into the hollow elongate member 120 to expand the elongate member 120 proximal of the cap member 110 b .
  • the expanded portion of the hollow elongate member 120 may secure the cap member 110 b in place by limiting movement by the cap member 110 b in a proximal direction.
  • FIG. 2 illustrates another example closure device.
  • the example closure device 200 of this configuration may be functionally similar to the example closure device 100 previously described above and shown in FIG. 1 in most respects. Certain features will not be described in relation to this configuration where those components may function in the manner as described above and are hereby incorporated into this additional configuration described below. Like structures and/or components may be given like reference numerals.
  • the closure device 200 may include a plurality of closure members 210 coupled to a plurality of elongate members 220 a , 220 b .
  • the plurality of closure members 210 may include an anchor member 210 a and/or a cap member 210 b .
  • the anchor member 210 a may be coupled to the distal ends of the elongate members 220 a , 220 b and/or the cap member 210 b may be disposed on the elongate members 220 a , 220 b proximal of the anchor member 210 a.
  • the elongate members 220 a , 220 b may include plurality of sutures extending together along at least a portion of the length of the closure device 300 .
  • the elongate members 220 a , 220 b may include shafts and/or sutures.
  • the elongate members 220 a , 220 b may be coupled together and/or to the anchor member 210 a at their distal ends.
  • the elongate members 220 a , 220 b may be coupled together and/or coupled to the anchor member 210 a using a distal knot 230 a .
  • the distal knot 230 a may be a heat formed knot.
  • the elongate members 220 a , 220 b may form a proximal knot 230 b at a position proximal of the cap member 210 b .
  • the proximal knot 230 b may be configured to be advanced in a distal direction and/or secure the cap member 210 b in apposition to the anchor member 210 a on opposite sides of a lumen wall.
  • the elongate members 220 a , 220 b may be flexible and include surgical silk or thread, which may be bioabsorbable.
  • the elongate member 120 in FIG. 1 ) may be relatively stiff.
  • the closure system 1000 may include a closure device 300 , a generally tubular outer member 1010 , a generally tubular inner member 1030 , and a generally tubular intermediate member 1020 .
  • the example closure device 300 included in the closure system 1000 of this configuration may be functionally similar to the example closure devices 100 , 200 previously described above and shown in FIGS. 1-2 in most respects, where certain features will not be described in relation to this configuration wherein those components may function in the manner as described above and are hereby incorporated into this additional configuration described below.
  • Like structures and/or components may be given like reference numerals.
  • the closure device 300 may include an anchor member 310 a , a cap member 310 b , and an elongate member 320 .
  • the closure device 300 may be disposed at least partially within the outer member 1010 proximate a distal opening 1015 of the outer member 1010 .
  • the intermediate member 1020 may be disposed at least partially within the outer member 1010 proximal of the closure device 300 .
  • the distal end of the intermediate member 1020 may be disposed within the proximal end of the outer member 1010 .
  • the proximal end of the intermediate member 1020 may also extend out of the proximal end of the outer member 1010 for operation by a medical practitioner.
  • the inner member 1030 may be disposed at least partially within the outer member 1010 and/or the intermediate member 1020 .
  • the closure device 300 may be disposed on or along side the inner member 1030 .
  • the anchor member 310 a and/or cap member 310 b may fold or wrap at least partially around the inner member 1030 .
  • the elongate member 320 of the closure device 300 may extend through a distal opening in the inner member 1030 and out a proximal opening in the inner member 1030 for operation by a medical practitioner.
  • the outer member 1010 may be configured to advance to a lumen opening while carrying the other components of the closure system 1000 .
  • the outer member 1010 may have a generally tapered distal end to facilitate entry into a body lumen through a lumen opening.
  • the outer member 1010 may have a distal opening 1015 through which the inner member 1030 may pass and through which the closure device 300 may be deployed.
  • the outer member 1010 may include a non-rigid catheter.
  • the outer member 1010 may have any dimensions desired. For example, as shown in FIG. 3A , the outer member may have a substantially constant diameter along a majority of its length. However, in further implementations, the outer member 1010 may have a varying diameter. In a yet further implementation, the thickness of the outer member 1010 may vary along its length. For example, the thickness of the outer member may increase near the distal end. As a result, the inner diameter of the outer member may decrease near the distal end, creating a conical or funnel-like interior surface of the outer member 1010 . The reduced inner diameter of the outer member 1010 may allow for a reduction of setting of the anchor member 310 a and/or cap member 310 b from age and/or sterilization.
  • the anchor member 310 a and/or cap member 310 b may be disposed with the outer member proximate its proximal end or within a handle portion of the closure system 1000 prior to deployment through the distal opening 1015 of the outer member 1010 .
  • the intermediate member 1020 may be configured to deploy the anchor member 310 a and/or cap member 310 b of the closure device 300 through the distal opening 1015 in the outer member 1010 .
  • the intermediate member 1020 may be disposed within the outer member 1010 and positioned proximal of and/or abutting the closure device 300 .
  • the intermediate member 1020 may be configured to translate in a distal direction relative to the outer member 1010 in order to push at least a portion of the closure device 300 through the distal opening 1015 of the outer member 1010 and/or to deploy the anchor member 310 a and/or cap member 310 b .
  • the intermediate member 1020 may be advanced in a distal direction relative to the outer member 1010 to deploy the anchor member 310 a from the distal end of the outer member 1010 and/or into the lumen.
  • the intermediate member 1020 may be configured to limit its range of movement in order to reduce instances of inadvertent deployment of the cap member 310 b within the lumen. For example, the distance that the proximal end of the intermediate member 1020 extends beyond the proximal end of the outer member 1010 may be equal to the distance necessary to deploy the anchor member 310 a . In a further embodiment, the intermediate member 1020 may be configured to limit further distal movement of the intermediate member 1020 relative to the outer member 1010 once the relative movement necessary to deploy only the anchor member 310 a has been achieved.
  • the proximal end of the intermediate member 1020 may include one or more flanges at its proximal end configured to abut the proximal end of the outer member once the relative movement necessary to deploy only the anchor member 310 a has been achieved.
  • the inner member 1030 may pass through the intermediate member 1020 and/or outer member 1010 and extend out the distal and/or proximal ends of the outer member 1010 and/or intermediate member 1020 , respectively.
  • the distal end of the inner member 1030 may be configured to at least partially close the distal opening 1015 in the outer member 1010 in order to reduce instances of premature and/or inadvertent deployment of the closure device 300 .
  • the inner member 1030 may include an inner lumen.
  • the inner lumen of the inner member 1030 may operate as a guidewire lumen, such that the closure system 1000 may advance over a guidewire into a body lumen through an opening in the body lumen wall.
  • the elongate member 320 of the closure device 300 may also be at least partially disposed through the inner member 1030 .
  • the inner member 1030 may be configured to operate as and/or include a marker port and/or a flow back lumen, such as blood mark race and/or bleed back lumen, to indicate when the distal end of the closure system 1000 has entered the body lumen.
  • FIG. 3B illustrates an additional example closure system 1000 ′ in accordance with an implementation of the present invention.
  • the closure system 1000 ′ of this configuration may be functionally similar to the example closure system 1000 previously described above and shown in FIG. 3A in most respects, wherein certain features will not be described in relation to this configuration where those components may function in the manner as described above and are hereby incorporated into this additional configuration described below.
  • Like structures and/or components may be given like reference numerals.
  • the closure system 1000 ′ may differ from the closure system 1000 of FIG. 3A by integrating the intermediate member 1020 and inner member 1030 into a single component, namely intermediate member 1020 ′.
  • the intermediate member 1020 ′ may include a proximal portion 1020 a ′ and a distal portion 1020 b ′.
  • the proximal portion 1020 a ′ may have a larger diameter than the distal portion 1020 b ′.
  • the anchor member 310 a ′ and/or cap member 310 b ′ of the closure device may be disposed on or proximate to the distal portion 1020 b ′ of the intermediate member 1020 ′ within the outer member 1010 ′ and distal of the proximal portion 1020 a ′ of the intermediate member 1020 ′.
  • the proximal portion 1020 a ′ may assist in pushing or deploying the anchor member 310 a ′ and/or cap member 310 b ′ through a distal opening 1015 ′ in the outer member 1010 ′.
  • the intermediate member 1020 ′ may also define a lumen through which the elongate member 320 ′, a guidewire, or body fluid may pass.
  • the closure system 1000 ′ may have less moving parts than the closure system 1000 of FIG. 3A but may, nonetheless, operate similarly to deploy the closure device 300 ′ to close a body lumen opening.
  • FIG. 3C illustrates an additional example closure system 1000 ′′ in accordance with an implementation of the present invention.
  • the closure system 1000 ′′ of this configuration may be functionally similar to the example closure systems 1000 , 1000 ′ previously described above and shown in FIGS. 3A-3B in most respects, wherein certain features will not be described in relation to this configuration where those components may function in the manner as described above and are hereby incorporated into this additional configuration described below.
  • Like structures and/or components may be given like reference numerals.
  • the closure system 1000 ′′ may include a plug 400 .
  • the plug 400 may be configured to close an opening in a body lumen or a corresponding tissue tract.
  • the plug 400 may be disposed within the closure system 1000 ′′ and configured for deployment proximate the body lumen opening.
  • the plug 400 may be disposed within the closure system 1000 ′′ on the inner member 1030 ′′ and distal of the intermediate member 1020 ′′.
  • the plug 400 may be disposed on the elongate member 320 ′′ of the closure device 300 ′′ proximal of the anchor member 310 a ′′ and/or cap member 310 b ′′.
  • the plug 400 may comprise any material known or used for closing a body lumen opening or tissue tract, including biodegradable materials, bioerodible materials, bioabsorbable materials, bioresorbable materials, other materials, or combinations thereof.
  • the plug 400 may comprise collagen and/or polyethylene glycol.
  • FIGS. 4-11 illustrate an example method of deploying the closure device 300 using the closure system 1000 of FIG. 3 .
  • FIG. 4 illustrates that the closure system 1000 may be advanced through a tissue tract and at least partially into a body lumen through a lumen opening to be obstructed or closed.
  • the closure system 1000 may be advanced into the lumen over a guidewire 1040 .
  • the guidewire may pass through the inner member 1030 of the closure system 1000 .
  • the inner member 1030 may include and/or operate as a fluid mark race and/or flow back lumen in order to indicate to a user that the distal end of the closure system 1000 has entered the body lumen.
  • the closure system 1000 may be advanced in an artery, until a pulsatile blood mark is indicated at the proximal end of the inner member 1030 .
  • the inner member 1030 and/or guidewire 1040 may be retracted as illustrated in FIG. 5 .
  • the inner member 1030 may be removed by pulling on the inner member 1030 while stabilizing the remaining components of the closure system 1000 .
  • removing the inner member 1030 from the closure system 1000 may facilitate deployment of the closure device 300 through the distal opening 1015 of the outer member 1010 .
  • the intermediate member 1020 may be advanced in a distal direction to deploy the anchor member 310 a of the closure device 300 into the lumen as illustrated in FIG. 6 .
  • the anchor member 310 a which may have been folded and/or otherwise compacted while disposed within the outer member 1010 , may expand into a deployed state.
  • the outer member 1010 may be refracted and/or the elongate member 320 of the closure device 300 may be tensioned for the anchor member 310 a to engage the distal surface of the lumen wall proximate the lumen opening as illustrated in FIG. 7 .
  • the outer member 1010 may continue to retract, and the resulting tension in the elongate member 320 caused by the secured anchor member 310 a may deploy the cap member 310 b from the distal opening 1015 of the outer member 1010 as illustrated in FIGS. 8-9 .
  • the intermediate member 1020 may be used to deploy the cap member 310 b.
  • the cap member 310 b Once the cap member 310 b is deployed within the tissue tract proximal of the lumen wall, it may then be advanced into apposition with the anchor member 310 a , as illustrated in FIG. 10 , in order to engage the anchor member 310 a and/or cap member 310 b with opposing surfaces of the lumen wall. During this process, the position of the anchor member 310 a may be retained by maintaining tension in the elongate member 320 as the outer member 1010 is withdrawn and/or as the cap member 310 b is advanced.
  • a knot and/or cleat 330 may be advanced along the elongate member 320 of the closure device 300 and/or secure the cap member 310 b against the anchor member 310 a with the lumen wall sandwiched at least partially therebetween, thereby further securing the closure members in place.
  • the elongate member 320 may include a plurality of projections (i.e., 125 , FIG. 1 ) extending from a surface thereof and configured to secure the cap member 310 b in place and prevent proximal movement of the cap member 310 b relative to the elongate member 320 .
  • the elongate member 320 may be trimmed proximal of the cap member 310 b , such as by using a suture trimmer 340 , and then retracted, as shown in FIG. 11 .
  • one or more additional locking mechanisms as disclosed in more detail herein may be used to secure the cap member 310 b and/or anchor member 310 a in place.
  • the cap member 310 b and the anchor member 310 a can close or substantially close an opening in a body lumen.
  • the vessel or tissue adjacent the opening can be disposed at least partially between the cap member 310 b and the anchor member 310 a .
  • the cap member 310 b and the anchor member 310 a can apply pressure to the tissue or vessel to hold the tissue in place and close the opening.
  • the cap member 310 b and the anchor member 310 a may be configured to also bond or become connected to the tissue to further close the opening.
  • the cap member 310 b and the anchor member 310 a may slightly deform as tension is applied to accommodate the tissue that is between the cap member 310 b and the anchor member 310 a.

Abstract

The present disclosure includes vessel closure devices, systems, and methods. A closure device configured to close an opening in a body lumen may include an elongate member having a distal end and a proximal end. An anchor member may be disposed on the elongate member proximate the distal end of the elongate member. A cap member may also be disposed on the elongate member a distance from the distal end of the elongate member. The anchor member and the cap member cooperate to close the opening in the body lumen.

Description

    CROSS-REFERENCE TO RELATED APPLICATIONS
  • This U.S. patent application claims the benefit of and priority to U.S. Provisional Patent Application having Ser. No. 61/145,468, filed on Jan. 16, 2009, the disclosure of which is incorporated herein by reference in its entirety.
  • BACKGROUND
  • 1. Technical Field
  • The present disclosure relates generally to medical devices, systems, and methods. In particular, the present disclosure relates to vessel closure devices, systems, and methods.
  • 2. Technology
  • Catheterization and interventional procedures, such as angioplasty or stenting, generally are performed by inserting a hollow needle through a patient's skin and tissue into the patient's vascular system. A guidewire may be advanced through the needle and into the patient's blood vessel accessed by the needle. The needle is then removed, enabling an introducer sheath to be advanced over the guidewire into the vessel, e.g., in conjunction with or subsequent to a dilator.
  • A catheter or other device may then be advanced through a lumen of the introducer sheath and over the guidewire into a position for performing a medical procedure. Thus, the introducer sheath may facilitate introducing various devices into the vessel, while minimizing trauma to the vessel wall and/or minimizing blood loss during a procedure.
  • Upon completing the procedure, the devices and introducer sheath are removed, leaving a puncture site in the vessel wall. Traditionally, external pressure is applied to the puncture site until clotting and wound sealing occur; however, the patient must remain bedridden for a substantial period after clotting to ensure closure of the wound. This procedure, however, may be time consuming and expensive, requiring as much as an hour of a physician's or nurse's time. It is also uncomfortable for the patient and requires that the patient remain immobilized in the operating room, catheter lab, or holding area. In addition, a risk of hematoma exists from bleeding before hemostasis occurs.
  • BRIEF SUMMARY
  • The present disclosure includes vessel closure devices, systems, and methods. In particular, the devices, systems, and methods of the present disclosure may allow a medical service provider to efficiently and quickly close an opening in a body lumen in a cost effective manner. In addition, the devices, systems, and methods of the present disclosure may allow for the closing of smaller body lumen openings using fewer parts than prior devices and systems.
  • According to one embodiment of the present disclosure, a closure device configured to close an opening in a body lumen may include an elongate member having a distal end and a proximal end. In addition, an anchor member may be disposed on the elongate member proximate the distal end of the elongate member. A cap member may also be disposed on the elongate member a distance from the distal end of the elongate member.
  • These and other advantages and features of the present disclosure will become more fully apparent from the following description and appended claims, or may be learned by the practice of the invention as set forth hereinafter.
  • BRIEF DESCRIPTION OF THE DRAWINGS
  • To further clarify the advantages and features of the present disclosure, a more particular description of the disclosure will be rendered by reference to example embodiments thereof which are illustrated in the appended drawings. It is appreciated that these drawings depict only example embodiments of the disclosure and are therefore not to be considered limiting of its scope. The example embodiments will be described and explained with additional specificity and detail through the use of the accompanying drawings in which:
  • FIG. 1 illustrates an example closure device for closing an opening in a body lumen or other tissue;
  • FIG. 2 illustrates an another example closure device for closing an opening in a body lumen or other tissue;
  • FIG. 3A illustrates an example closure system for closing an opening in a body lumen or other tissue;
  • FIG. 3B illustrates an additional example closure system;
  • FIG. 3C illustrates a further example closure system; and
  • FIGS. 4-11 illustrate an example method of closing a lumen opening.
  • DETAILED DESCRIPTION
  • The present disclosure includes devices, systems, and methods for closing an opening in a body lumen or other tissue. In particular, an example closure system may allow for at least one of reduced production costs, ease of use, and more effective hemostasis. In addition, embodiments of the closure system disclosed herein may allow for the closure of smaller openings in body lumens or other tissue.
  • In one embodiment, the closure system may include a closure device. The closure device may include an elongate member, such as a suture or shaft, an anchor member (or foot), and a cap member. The closure device may be disposed within or deployed by the closure system. The closure system may include an outer member, an inner member, an intermediate member, or combinations thereof configured to deploy a closure device from the closure system.
  • Reference is now made to FIG. 1, which illustrates an example closure device 100. The closure device 100 may include a plurality of closure members 110 coupled to an elongate member 120. In particular, the plurality of closure members 110 may include an anchor member 110 a and/or a cap member 110 b. In one embodiment, the anchor member 110 a may be disposed near a distal end of the elongate member 120. In a further embodiment, the cap member 110 b may be proximate the anchor member 110 a and/or spaced a distance away from the distal end of the elongate member 120.
  • The anchor member 110 a may be configured to be deployed through an opening in a body lumen in order to secure the closure device 100 from a point distal to the lumen opening. For example, the anchor member 110 a may be configured to move from a compressed, folded, or compacted first position having a dimension smaller than a lumen opening to a deployed, unfolded, or expanded second position having a dimension larger than the lumen opening. As a result, the anchor member 110 a may pass through the lumen opening while in the first position and thereafter may move to the second position and provide an anchor against the distal side of the lumen wall proximate the lumen opening.
  • The elongate member 120 may extend proximally from the deployed anchor member 110 a and/or may be tensioned to secure the anchor member 110 a proximate the lumen opening and/or against a distal surface of a lumen wall once deployed. In a further embodiment, the elongate member 120 may pass through the cap member 110 b, which may be deployed at a position proximal of the lumen wall. Once deployed, the cap member 110 b may be moved in a distal direction and/or may engage the proximal surface of the lumen wall. As a result, the anchor member 110 a and/or cap member 110 b may at least partially close the lumen opening.
  • The closure device 100 including, but not limited to, the anchor member 110 a and/or cap member 110 b, may include one or more biocompatible, bioabsorbable, bioresorbable, other materials, or combinations thereof. Examples of such materials may include a suitable hydrogel, hydrophilic polymer, biodegradable polymers, bioabsorbable polymers and bioneutral polymers. Examples of such polymers may include poly(alpha-hydroxy esters), polylactic acids, polylactides, poly-L-lactide, poly-DL-lactide, poly-L-lactide-co-DL-lactide, polyglycolic acids, polyglycolide, polylactic-co-glycolic acids, polyglycolide-co-lactide, polyglycolide-co-DL-lactide, polyglycolide-co-L-lactide, polyanhydrides, polyanhydride-co-imides, polyesters, polyorthoesters, polycaprolactones, polyesters, polyanydrides, polyphosphazenes, polyester amides, polyester urethanes, polycarbonates, polytrimethylene carbonates, polyglycolide-co-trimethylene carbonates, poly(PBA-carbonates), polyfumarates, polypropylene fumarate, poly(p-dioxanone), polyhydroxyalkanoates, polyamino acids, poly-L-tyrosines, poly(beta-hydroxybutyrate), polyhydroxybutyrate-hydroxyvaleric acids, combinations thereof, and/or the like.
  • In one embodiment, the closure device 100, including, but not limited to, the anchor member 110 a and/or cap member 110 b, may be coated with an active pharmaceutical ingredient with or without a polymeric carrier. The active pharmaceutical ingredient can be any drug. In one embodiment, the pharmaceutical ingredient may increase tissue growth.
  • The polymeric coating and drug may be configured to cooperate so as to form a diffusion pathway (e.g., lipophilic, hydrophilic, and/or amphipathic) with tissue when at least a portion of the closure device 100 engages tissue. This may facilitate diffusion into the tissue instead of into a body fluid passing over the closure device 100.
  • The closure device 100 or any portion thereof may be loaded with and deliver beneficial agents or drugs, such as therapeutic agents, pharmaceuticals and radiation therapies. Accordingly, the closure device 100 and/or coating material may contain a drug or beneficial agent to improve the use of the closure device 100. Such drugs or beneficial agents may include antithrombotics, anticoagulants, antiplatelet agents, thrombolytics, antiproliferatives, anti-inflammatories, hemostatic agents, agents that inhibit hyperplasia, inhibitors of smooth muscle proliferation, antibiotics, growth factor inhibitors, or cell adhesion inhibitors, as well as antineoplastics, antimitotics, antifibrins, antioxidants, agents that promote endothelial cell recovery, antiallergic substances, radiopaque agents, viral vectors having beneficial genes, genes, siRNA, antisense compounds, oligionucleotides, cell permeation enhancers, and combinations thereof. Another example of a suitable beneficial agent is described in U.S. Pat. No. 6,015,815 and U.S. Pat. No. 6,329,386 entitled “Tetrazole-containing rapamycin analogs with shortened half-lives”, the entireties of which are herein incorporated by reference.
  • The anchor member 110 a and/or cap member 110 b may include any shape configured to facilitate obstruction of a lumen opening. In one embodiment, the anchor member 110 a and/or cap member 110 b may have a disc-like shape. For example, the anchor member 110 a and/or cap member 110 b may include a generally flat piece of material that may be circular or oval in shape. The anchor member 110 a and/or cap member 110 b may incorporate other shapes and/or configurations. For example, the anchor member 110 a and/or cap member 110 b may have an elliptical and/or polygonal shape. In a further embodiment, the closure members 110 may be rectangular in shape along the length thereof with rounded and/or triangular ends or corners.
  • In one implementation, the thickness of the anchor member 110 a and/or cap member 110 b may be continuous throughout the anchor member 110 a and/or cap member 110 b. In further implementations, however, the thickness of the anchor member 110 a and/or cap member 110 b may vary as desired for a particular application. For example, the thickness of the anchor member 110 a and/or cap member 110 b may be greater near the center than along the outer edge of the anchor member 110 a and/or cap member 110 b. In a yet further example, the thickness of the anchor member 110 a and/or cap member 110 b may be greater along a first axis extending through the center of the anchor member 110 a and/or cap member 110 b and progressively thinner extending away from the first axis. As a result, the anchor member 110 a and/or cap member 110 b may allow bending about the first axis but may resist bending about an axis perpendicular to or different from the first axis. In yet further implementations, the thickness of the anchor member 110 a and/or cap member 110 b may vary as desired to achieve a particular strength, rigidity, flexibility, and/or other mechanical property.
  • In one implementation, the anchor member 110 a and cap member 110 b may have the same shape, size, coating, and/or other characteristics, and/or combinations thereof. In a further embodiment, the shape, size, coating, and/or other characteristics of the anchor member 110 a may be different than those of the cap member 110 b.
  • As mentioned, the closure device 100 may include an elongate member 120. In one embodiment, the anchor member 110 a may be coupled to a distal end of the elongate member 120 and/or the cap member 110 b may be disposed on the elongate member 120 at a position along the length of the elongate member 120. The elongate member 120 may include one or more bioabsorbable materials and/or beneficial agents, such as any bioabsorbable material and/or beneficial agents disclosed herein. In a further embodiment, the elongate member 120 may include a bioabsorbable metal, alloy, polymer, plastic, composite, other materials, or combinations thereof. The elongate member 120 may include a single limb, such as disclosed in FIG. 1, or may include a plurality of limbs, such as disclosed in FIG. 2. In one example embodiment, the elongate member 120 may include a suture or a plurality of sutures. In a further embodiment, the elongate member 120 may include an elongate shaft or a plurality of elongate shafts. In a yet further embodiment, at least a portion of the elongate member 120 may be generally tubular or hollow.
  • The closure device 100 may be configured to resist proximal movement of the cap member 110 b and/or distal movement of the anchor member 110 a after deployment. For example, in one embodiment, a knot may be disposed on the elongate member 120 proximal of the cap member 110 b to secure the cap member 110 b and/or anchor member 110 a in place. In a further embodiment, a cleat, such as a bioabsorbable plastic cleat, may be positioned to secure the cap member 110 b and/or anchor member 110 a in place. For example, the cleat may be positioned along the elongate member 120 proximal of and/or abutting the cap member 110 b. The cleat may maintain sufficient tension in the elongate member 120 to maintain the cap member 110 b and anchor member 110 a securely in a deployed position, such as in apposition with the lumen wall and/or lumen opening therebetween. In particular, the anchor member 110 a and cap member 110 b may sandwich the lumen wall surrounding a lumen opening to achieve closure of the lumen opening.
  • In a further embodiment, the closure device 100 may include a mechanism to lock and/or secure the anchor member 110 a and cap member 110 b in place. In one example embodiment, the elongate member 120 may have a uniform thickness along its length and/or pass through an aperture in the cap member 110 b configured to produce sufficient frictional force between the cap member 110 b and elongate member 120 to resist relative movement between the elongate member 120 and cap member 110 b. In particular, this configuration may allow the cap member 110 b to be deployed by sliding the cap member 110 b in a distal direction along the elongate member 120 to secure the cap member 110 b and anchor member 110 a in place. Once deployed, the frictional force between the elongate member 120 and the cap member 110 b may prevent and/or resist further movement by the cap member 110 b and/or anchor member 110 a.
  • In a further embodiment, the closure device 100 may include a barbed and/or ratchet design to secure the cap member 110 b and anchor member 110 a in the deployed configuration. For example, the elongate member 120 may include a plurality of projections 125 disposed along the length thereof. The projections 125 may include barbs, teeth, ridges, and/or other similar projections. The projections 125 may be configured to allow the cap member 110 b to move in a distal direction but may resist/prevent movement by the cap member 110 b in a proximal direction. For example, the projections 125 may be angled and/or extend in a distal direction to allow the cap member 110 b to pass over the projections 125 in a distal direction but to prevent the cap member 110 b from then passing back over the projections 125 in a proximal direction. Accordingly, once the anchor member 110 a is deployed and/or secured against the distal surface of the lumen wall, the cap member 110 b may be advanced along the elongate member 120 over the projections 125. The cap member 110 b may be secured against the proximal surface of the lumen wall and/or held in place by one or more of the projections 125 of the elongate member 120.
  • In yet a further embodiment, the locking mechanism (i.e., knot, cleat, projections, etc.) may be independent of the cap member 110 b. In particular, decoupling the locking mechanism from the cap member 110 b may allow for the independent optimization of the locking mechanism and/or the cap member 110 b. For example, the closure device 100 may further include a sliding collet that may be advanced along the elongate member 120 and/or lock the cap member 110 b in place once deployed. The collet may incorporate one or more locking features that may be otherwise incorporated in the cap member 110 b as explained in more detail herein.
  • In a further embodiment, the cap member 110 b may be secured in place using a hollow elongate member 120 and a plug configured to be inserted into the elongate member 120. Once the anchor is deployed, the cap member 110 b may be moved along the hollow elongate member 120 into apposition with the anchor member 110 a, thereby applying pressure to opposite sides of the lumen wall near the lumen opening. A plug may be driven into the hollow elongate member 120 to expand the elongate member 120 proximal of the cap member 110 b. As a result, the expanded portion of the hollow elongate member 120 may secure the cap member 110 b in place by limiting movement by the cap member 110 b in a proximal direction.
  • Reference is now made to FIG. 2 which illustrates another example closure device. The example closure device 200 of this configuration may be functionally similar to the example closure device 100 previously described above and shown in FIG. 1 in most respects. Certain features will not be described in relation to this configuration where those components may function in the manner as described above and are hereby incorporated into this additional configuration described below. Like structures and/or components may be given like reference numerals.
  • In one embodiment, the closure device 200 may include a plurality of closure members 210 coupled to a plurality of elongate members 220 a, 220 b. The plurality of closure members 210 may include an anchor member 210 a and/or a cap member 210 b. In particular, the anchor member 210 a may be coupled to the distal ends of the elongate members 220 a, 220 b and/or the cap member 210 b may be disposed on the elongate members 220 a, 220 b proximal of the anchor member 210 a.
  • In one embodiment, the elongate members 220 a, 220 b may include plurality of sutures extending together along at least a portion of the length of the closure device 300. In a further example, the elongate members 220 a, 220 b may include shafts and/or sutures. The elongate members 220 a, 220 b may be coupled together and/or to the anchor member 210 a at their distal ends. For example, the elongate members 220 a, 220 b may be coupled together and/or coupled to the anchor member 210 a using a distal knot 230 a. In particular, the distal knot 230 a may be a heat formed knot. In a yet further embodiment, the elongate members 220 a, 220 b may form a proximal knot 230 b at a position proximal of the cap member 210 b. The proximal knot 230 b may be configured to be advanced in a distal direction and/or secure the cap member 210 b in apposition to the anchor member 210 a on opposite sides of a lumen wall. The elongate members 220 a, 220 b may be flexible and include surgical silk or thread, which may be bioabsorbable. Alternatively, the elongate member 120 (in FIG. 1) may be relatively stiff.
  • Reference is now made to FIG. 3A, which illustrates an example closure system 1000 for closing an opening in a body lumen or other tissue. In one embodiment, the closure system 1000 may include a closure device 300, a generally tubular outer member 1010, a generally tubular inner member 1030, and a generally tubular intermediate member 1020. The example closure device 300 included in the closure system 1000 of this configuration may be functionally similar to the example closure devices 100, 200 previously described above and shown in FIGS. 1-2 in most respects, where certain features will not be described in relation to this configuration wherein those components may function in the manner as described above and are hereby incorporated into this additional configuration described below. Like structures and/or components may be given like reference numerals.
  • In one embodiment, the closure device 300 may include an anchor member 310 a, a cap member 310 b, and an elongate member 320. The closure device 300 may be disposed at least partially within the outer member 1010 proximate a distal opening 1015 of the outer member 1010. The intermediate member 1020 may be disposed at least partially within the outer member 1010 proximal of the closure device 300. In particular, the distal end of the intermediate member 1020 may be disposed within the proximal end of the outer member 1010. The proximal end of the intermediate member 1020 may also extend out of the proximal end of the outer member 1010 for operation by a medical practitioner. The inner member 1030 may be disposed at least partially within the outer member 1010 and/or the intermediate member 1020. In a further embodiment, the closure device 300 may be disposed on or along side the inner member 1030. In particular, the anchor member 310 a and/or cap member 310 b may fold or wrap at least partially around the inner member 1030. The elongate member 320 of the closure device 300 may extend through a distal opening in the inner member 1030 and out a proximal opening in the inner member 1030 for operation by a medical practitioner.
  • The outer member 1010 may be configured to advance to a lumen opening while carrying the other components of the closure system 1000. In one embodiment, the outer member 1010 may have a generally tapered distal end to facilitate entry into a body lumen through a lumen opening. The outer member 1010 may have a distal opening 1015 through which the inner member 1030 may pass and through which the closure device 300 may be deployed. In one example embodiment, the outer member 1010 may include a non-rigid catheter.
  • In further implementations, the outer member 1010 may have any dimensions desired. For example, as shown in FIG. 3A, the outer member may have a substantially constant diameter along a majority of its length. However, in further implementations, the outer member 1010 may have a varying diameter. In a yet further implementation, the thickness of the outer member 1010 may vary along its length. For example, the thickness of the outer member may increase near the distal end. As a result, the inner diameter of the outer member may decrease near the distal end, creating a conical or funnel-like interior surface of the outer member 1010. The reduced inner diameter of the outer member 1010 may allow for a reduction of setting of the anchor member 310 a and/or cap member 310 b from age and/or sterilization. In a yet further implementation, the anchor member 310 a and/or cap member 310 b may be disposed with the outer member proximate its proximal end or within a handle portion of the closure system 1000 prior to deployment through the distal opening 1015 of the outer member 1010.
  • The intermediate member 1020 may be configured to deploy the anchor member 310 a and/or cap member 310 b of the closure device 300 through the distal opening 1015 in the outer member 1010. For example, the intermediate member 1020 may be disposed within the outer member 1010 and positioned proximal of and/or abutting the closure device 300. The intermediate member 1020 may be configured to translate in a distal direction relative to the outer member 1010 in order to push at least a portion of the closure device 300 through the distal opening 1015 of the outer member 1010 and/or to deploy the anchor member 310 a and/or cap member 310 b. For example, once a distal end of the outer member 1010 has advanced through a lumen opening into a lumen, the intermediate member 1020 may be advanced in a distal direction relative to the outer member 1010 to deploy the anchor member 310 a from the distal end of the outer member 1010 and/or into the lumen.
  • In one embodiment, the intermediate member 1020 may be configured to limit its range of movement in order to reduce instances of inadvertent deployment of the cap member 310 b within the lumen. For example, the distance that the proximal end of the intermediate member 1020 extends beyond the proximal end of the outer member 1010 may be equal to the distance necessary to deploy the anchor member 310 a. In a further embodiment, the intermediate member 1020 may be configured to limit further distal movement of the intermediate member 1020 relative to the outer member 1010 once the relative movement necessary to deploy only the anchor member 310 a has been achieved. For example, the proximal end of the intermediate member 1020 may include one or more flanges at its proximal end configured to abut the proximal end of the outer member once the relative movement necessary to deploy only the anchor member 310 a has been achieved.
  • The inner member 1030 may pass through the intermediate member 1020 and/or outer member 1010 and extend out the distal and/or proximal ends of the outer member 1010 and/or intermediate member 1020, respectively. In one embodiment, the distal end of the inner member 1030 may be configured to at least partially close the distal opening 1015 in the outer member 1010 in order to reduce instances of premature and/or inadvertent deployment of the closure device 300. In a further embodiment, the inner member 1030 may include an inner lumen. For example, the inner lumen of the inner member 1030 may operate as a guidewire lumen, such that the closure system 1000 may advance over a guidewire into a body lumen through an opening in the body lumen wall. As explained above, the elongate member 320 of the closure device 300 may also be at least partially disposed through the inner member 1030. In addition, the inner member 1030 may be configured to operate as and/or include a marker port and/or a flow back lumen, such as blood mark race and/or bleed back lumen, to indicate when the distal end of the closure system 1000 has entered the body lumen.
  • Reference is now made to FIG. 3B, which illustrates an additional example closure system 1000′ in accordance with an implementation of the present invention. The closure system 1000′ of this configuration may be functionally similar to the example closure system 1000 previously described above and shown in FIG. 3A in most respects, wherein certain features will not be described in relation to this configuration where those components may function in the manner as described above and are hereby incorporated into this additional configuration described below. Like structures and/or components may be given like reference numerals.
  • In particular, the closure system 1000′ may differ from the closure system 1000 of FIG. 3A by integrating the intermediate member 1020 and inner member 1030 into a single component, namely intermediate member 1020′. For example, the intermediate member 1020′ may include a proximal portion 1020 a′ and a distal portion 1020 b′. In one implementation, the proximal portion 1020 a′ may have a larger diameter than the distal portion 1020 b′. The anchor member 310 a′ and/or cap member 310 b′ of the closure device may be disposed on or proximate to the distal portion 1020 b′ of the intermediate member 1020′ within the outer member 1010′ and distal of the proximal portion 1020 a′ of the intermediate member 1020′. When the intermediate member 1020′ is advanced in a distal direction, the proximal portion 1020 a′ may assist in pushing or deploying the anchor member 310 a′ and/or cap member 310 b′ through a distal opening 1015′ in the outer member 1010′. The intermediate member 1020′ may also define a lumen through which the elongate member 320′, a guidewire, or body fluid may pass. As a result, the closure system 1000′ may have less moving parts than the closure system 1000 of FIG. 3A but may, nonetheless, operate similarly to deploy the closure device 300′ to close a body lumen opening.
  • Reference is now made to FIG. 3C, which illustrates an additional example closure system 1000″ in accordance with an implementation of the present invention. The closure system 1000″ of this configuration may be functionally similar to the example closure systems 1000, 1000′ previously described above and shown in FIGS. 3A-3B in most respects, wherein certain features will not be described in relation to this configuration where those components may function in the manner as described above and are hereby incorporated into this additional configuration described below. Like structures and/or components may be given like reference numerals.
  • As shown in FIG. 3C, in addition to or in conjunction with the closure device 300″, the closure system 1000″ may include a plug 400. The plug 400 may be configured to close an opening in a body lumen or a corresponding tissue tract. The plug 400 may be disposed within the closure system 1000″ and configured for deployment proximate the body lumen opening. In particular, the plug 400 may be disposed within the closure system 1000″ on the inner member 1030″ and distal of the intermediate member 1020″. In a further implementation, the plug 400 may be disposed on the elongate member 320″ of the closure device 300″ proximal of the anchor member 310 a″ and/or cap member 310 b″. The plug 400 may comprise any material known or used for closing a body lumen opening or tissue tract, including biodegradable materials, bioerodible materials, bioabsorbable materials, bioresorbable materials, other materials, or combinations thereof. In one implementation, the plug 400 may comprise collagen and/or polyethylene glycol.
  • Reference is now made to FIGS. 4-11 which illustrate an example method of deploying the closure device 300 using the closure system 1000 of FIG. 3. For example, FIG. 4 illustrates that the closure system 1000 may be advanced through a tissue tract and at least partially into a body lumen through a lumen opening to be obstructed or closed. As shown, the closure system 1000 may be advanced into the lumen over a guidewire 1040. In particular, the guidewire may pass through the inner member 1030 of the closure system 1000. The inner member 1030 may include and/or operate as a fluid mark race and/or flow back lumen in order to indicate to a user that the distal end of the closure system 1000 has entered the body lumen. For example, the closure system 1000 may be advanced in an artery, until a pulsatile blood mark is indicated at the proximal end of the inner member 1030.
  • Once the closure system 1000 is in position with the distal end thereof disposed within the lumen, the inner member 1030 and/or guidewire 1040 may be retracted as illustrated in FIG. 5. In particular, the inner member 1030 may be removed by pulling on the inner member 1030 while stabilizing the remaining components of the closure system 1000. In one embodiment, removing the inner member 1030 from the closure system 1000 may facilitate deployment of the closure device 300 through the distal opening 1015 of the outer member 1010.
  • Once the inner member 1030 has been removed, the intermediate member 1020 may be advanced in a distal direction to deploy the anchor member 310 a of the closure device 300 into the lumen as illustrated in FIG. 6. In one embodiment, the anchor member 310 a, which may have been folded and/or otherwise compacted while disposed within the outer member 1010, may expand into a deployed state.
  • After the anchor member 310 a is deployed, the outer member 1010 may be refracted and/or the elongate member 320 of the closure device 300 may be tensioned for the anchor member 310 a to engage the distal surface of the lumen wall proximate the lumen opening as illustrated in FIG. 7. The outer member 1010 may continue to retract, and the resulting tension in the elongate member 320 caused by the secured anchor member 310 a may deploy the cap member 310 b from the distal opening 1015 of the outer member 1010 as illustrated in FIGS. 8-9. In a further embodiment, the intermediate member 1020 may be used to deploy the cap member 310 b.
  • Once the cap member 310 b is deployed within the tissue tract proximal of the lumen wall, it may then be advanced into apposition with the anchor member 310 a, as illustrated in FIG. 10, in order to engage the anchor member 310 a and/or cap member 310 b with opposing surfaces of the lumen wall. During this process, the position of the anchor member 310 a may be retained by maintaining tension in the elongate member 320 as the outer member 1010 is withdrawn and/or as the cap member 310 b is advanced. In a further embodiment, a knot and/or cleat 330 may be advanced along the elongate member 320 of the closure device 300 and/or secure the cap member 310 b against the anchor member 310 a with the lumen wall sandwiched at least partially therebetween, thereby further securing the closure members in place. In a further embodiment, the elongate member 320 may include a plurality of projections (i.e., 125, FIG. 1) extending from a surface thereof and configured to secure the cap member 310 b in place and prevent proximal movement of the cap member 310 b relative to the elongate member 320. Once the cap member 310 b and anchor member 310 a are secured, the elongate member 320 may be trimmed proximal of the cap member 310 b, such as by using a suture trimmer 340, and then retracted, as shown in FIG. 11. In a further embodiment, one or more additional locking mechanisms as disclosed in more detail herein may be used to secure the cap member 310 b and/or anchor member 310 a in place.
  • Once deployed, the cap member 310 b and the anchor member 310 a can close or substantially close an opening in a body lumen. The vessel or tissue adjacent the opening can be disposed at least partially between the cap member 310 b and the anchor member 310 a. As the cap member 310 b is advanced, the cap member 310 b and the anchor member 310 a can apply pressure to the tissue or vessel to hold the tissue in place and close the opening. Further, the cap member 310 b and the anchor member 310 a may be configured to also bond or become connected to the tissue to further close the opening. Also, the cap member 310 b and the anchor member 310 a may slightly deform as tension is applied to accommodate the tissue that is between the cap member 310 b and the anchor member 310 a.
  • The embodiments of the present disclosure may be embodied in other specific forms without departing from its spirit or essential characteristics. The described embodiments are to be considered in all respects only as illustrative and not restrictive. The scope of the disclosure is, therefore, indicated by the appended claims rather than by the foregoing description. All changes which come within the meaning and range of equivalency of the claims are to be embraced within their scope.

Claims (28)

1. A closure device configured to close an opening in a body lumen, the closure device comprising:
an elongate member having a distal end and a proximal end;
an anchor member disposed on the elongate member proximate the distal end of the elongate member; and
a cap member disposed on the elongate member a distance from the distal end of the elongate member, wherein the anchor member and the cap member are positioned to close the opening in the body lumen.
2. The closure device of claim 1, wherein the elongate member comprises a metal or plastic shaft.
3. The closure device of claim 1, wherein the elongate member comprises a suture.
4. The closure device of claim 3, further comprising a second elongate member disposed substantially in parallel with the first elongate member, the second elongate member comprising a suture.
5. The closure device of claim 1, wherein the elongate member comprises a hollow shaft and the closure device further comprises a plug configured to be inserted into the hollow shaft to expand the hollow shaft.
6. The closure device of claim 1, wherein the elongate member comprises one or more projections disposed along the length thereof.
7. The closure device of claim 6, wherein the one or more projections are chosen from a group comprising teeth, barbs, and ridges.
8. The closure device of claim 6, wherein the one or more projections are configured to permit movement by the cap member in a distal direction and resist movement by the cap member in a proximal direction.
9. The closure device of claim 1, wherein the cap member is slidably disposed on the elongate member.
10. The closure device of claim 1, wherein the anchor member or cap member comprises a biodegradable material.
11. The closure device of claim 1, wherein the anchor member or cap member is disc shaped.
12. The closure device of claim 1, wherein the anchor member or cap member has a varying thickness.
13. The closure device of claim 1, wherein the elongate member comprises a bioabsorbable monofilament.
14. The closure device of claim 1, wherein the anchor member is coupled to the elongate member proximate a knot.
15. The closure device of claim 1, further comprising a cleat, collet, or knot disposed on the elongate member proximal of the cap member.
16. A closure system comprising:
a generally tubular outer member having a distal opening and a proximal opening;
a generally tubular intermediate member disposed at least partially within the outer member; and
a closure device disposed at least partially within the outer member, the closure device comprising:
an elongate member having a distal end and a proximal end, the elongate member being disposed at least partially through the intermediate member;
an anchor member disposed on the elongate member proximate the distal end of the elongate member, the anchor member being further disposed within the outer member distal of the intermediate member; and
a cap member disposed on the elongate member a distance from the distal end of the elongate member, the cap member being further disposed within the outer member proximal of the anchor member.
17. The closure system of claim 16, wherein the outer member comprises a non-rigid catheter.
18. The closure system of claim 16, further comprising a generally tubular inner member disposed at least partially within the outer member and/or intermediate member.
19. The closure system of claim 18, wherein the inner member comprises a guidewire lumen, fluid marker port, and/or flow back lumen.
20. The closure system of claim 18, wherein the inner member and the intermediate member are integrated together into a single component.
21. The closure system of claim 16, wherein the intermediate member comprises a pusher tube.
22. The closure system of claim 16, wherein the intermediate member is movable relative to the outer member.
23. The closure system of claim 22, wherein the distal movement of the intermediate member relative to the outer member is limited to the movement necessary deploy the anchor member from the distal opening of the outer member.
24. The closure system of claim 16, further comprising a collagen or polyethylene glycol plug configured to at least partially obstruct a tissue tract proximate a body lumen opening.
25. A method of closing an opening in a lumen wall, the method comprising:
advancing the distal end of a closure system over a guidewire into a body lumen, the closure system comprising:
a generally tubular outer member having a distal opening and a proximal opening;
a generally tubular intermediate member disposed at least partially within the outer member; and
a closure device disposed at least partially within the outer member, the closure device comprising:
an elongate member having a distal end and a proximal end, the elongate member being disposed at least partially through the intermediate member;
an anchor member disposed on the elongate member proximate the distal end of the elongate member, the anchor member being further disposed within the outer member distal of the intermediate member; and
a cap member disposed on the elongate member a distance from the distal end of the elongate member, the cap member being further disposed within the outer member proximal of the anchor member.
deploying the anchor member into the lumen;
tensioning the elongate member to engage the anchor member with a distal surface of the lumen wall; and
deploying the cap member and advancing the cap member in a distal direction along the elongate member to engage a proximal surface of the lumen wall.
26. The method of claim 25, further comprising positioning a knot, collet, or cleat on the elongate member proximal of the cap member.
27. The method of claim 25, further comprising retracting the outer member in a proximal direction to deploy the cap member.
28. The method of claim 25, wherein the closure system further comprises a generally tubular inner member disposed at least partially within the intermediate member.
US12/688,065 2009-01-16 2010-01-15 Closure devices, systems, and methods Abandoned US20100185234A1 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
US12/688,065 US20100185234A1 (en) 2009-01-16 2010-01-15 Closure devices, systems, and methods
US14/323,753 US9414824B2 (en) 2009-01-16 2014-07-03 Closure devices, systems, and methods

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US14546809P 2009-01-16 2009-01-16
US12/688,065 US20100185234A1 (en) 2009-01-16 2010-01-15 Closure devices, systems, and methods

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US14/323,753 Division US9414824B2 (en) 2009-01-16 2014-07-03 Closure devices, systems, and methods

Publications (1)

Publication Number Publication Date
US20100185234A1 true US20100185234A1 (en) 2010-07-22

Family

ID=42337547

Family Applications (2)

Application Number Title Priority Date Filing Date
US12/688,065 Abandoned US20100185234A1 (en) 2009-01-16 2010-01-15 Closure devices, systems, and methods
US14/323,753 Active US9414824B2 (en) 2009-01-16 2014-07-03 Closure devices, systems, and methods

Family Applications After (1)

Application Number Title Priority Date Filing Date
US14/323,753 Active US9414824B2 (en) 2009-01-16 2014-07-03 Closure devices, systems, and methods

Country Status (1)

Country Link
US (2) US20100185234A1 (en)

Cited By (63)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7879071B2 (en) 2000-12-07 2011-02-01 Integrated Vascular Systems, Inc. Closure device and methods for making and using them
US7901428B2 (en) 2000-01-05 2011-03-08 Integrated Vascular Systems, Inc. Vascular sheath with bioabsorbable puncture site closure apparatus and methods of use
US7918873B2 (en) 2001-06-07 2011-04-05 Abbott Vascular Inc. Surgical staple
US7931669B2 (en) 2000-01-05 2011-04-26 Integrated Vascular Systems, Inc. Integrated vascular device with puncture site closure component and sealant and methods of use
US8007512B2 (en) 2002-02-21 2011-08-30 Integrated Vascular Systems, Inc. Plunger apparatus and methods for delivering a closure device
US8182497B2 (en) 2000-12-07 2012-05-22 Integrated Vascular Systems, Inc. Closure device
US8192459B2 (en) 2002-06-04 2012-06-05 Abbott Vascular Inc. Blood vessel closure clip and delivery device
WO2012047815A3 (en) * 2010-10-04 2012-06-14 The Johns Hopkins University Method and device for closure of intraluminal perforations
US8202294B2 (en) 2003-01-30 2012-06-19 Integrated Vascular Systems, Inc. Clip applier and methods of use
US8202283B2 (en) 2002-12-31 2012-06-19 Integrated Vascular Systems, Inc. Methods for manufacturing a clip and clip
US8202293B2 (en) 2003-01-30 2012-06-19 Integrated Vascular Systems, Inc. Clip applier and methods of use
US8226681B2 (en) 2007-06-25 2012-07-24 Abbott Laboratories Methods, devices, and apparatus for managing access through tissue
US8303624B2 (en) 2010-03-15 2012-11-06 Abbott Cardiovascular Systems, Inc. Bioabsorbable plug
US8313497B2 (en) 2005-07-01 2012-11-20 Abbott Laboratories Clip applier and methods of use
US8323312B2 (en) 2008-12-22 2012-12-04 Abbott Laboratories Closure device
WO2012174469A2 (en) 2011-06-16 2012-12-20 Curaseal Inc. Fistula treatment devices and related methods
US8398676B2 (en) 2008-10-30 2013-03-19 Abbott Vascular Inc. Closure device
US8398656B2 (en) 2003-01-30 2013-03-19 Integrated Vascular Systems, Inc. Clip applier and methods of use
US20130123844A1 (en) * 2011-11-16 2013-05-16 St. Jude Medical Puerto Rico Llc Large bore closure device with inner and outer seals
US8556930B2 (en) 2006-06-28 2013-10-15 Abbott Laboratories Vessel closure device
US8590760B2 (en) 2004-05-25 2013-11-26 Abbott Vascular Inc. Surgical stapler
US8597325B2 (en) 2000-12-07 2013-12-03 Integrated Vascular Systems, Inc. Apparatus and methods for providing tactile feedback while delivering a closure device
US8603116B2 (en) 2010-08-04 2013-12-10 Abbott Cardiovascular Systems, Inc. Closure device with long tines
US8672953B2 (en) 2007-12-17 2014-03-18 Abbott Laboratories Tissue closure system and methods of use
US8690910B2 (en) 2000-12-07 2014-04-08 Integrated Vascular Systems, Inc. Closure device and methods for making and using them
US8758398B2 (en) 2006-09-08 2014-06-24 Integrated Vascular Systems, Inc. Apparatus and method for delivering a closure element
US8758400B2 (en) 2000-01-05 2014-06-24 Integrated Vascular Systems, Inc. Closure system and methods of use
US8758399B2 (en) 2010-08-02 2014-06-24 Abbott Cardiovascular Systems, Inc. Expandable bioabsorbable plug apparatus and method
US8784447B2 (en) 2000-09-08 2014-07-22 Abbott Vascular Inc. Surgical stapler
US20140222064A1 (en) * 2013-02-01 2014-08-07 St. Jude Medical Puerto Rico Llc Dual lumen carrier tube with retractable sleeve and methods
US8808310B2 (en) 2006-04-20 2014-08-19 Integrated Vascular Systems, Inc. Resettable clip applier and reset tools
US8821534B2 (en) 2010-12-06 2014-09-02 Integrated Vascular Systems, Inc. Clip applier having improved hemostasis and methods of use
US8820602B2 (en) 2007-12-18 2014-09-02 Abbott Laboratories Modular clip applier
US8858594B2 (en) 2008-12-22 2014-10-14 Abbott Laboratories Curved closure device
US8893947B2 (en) 2007-12-17 2014-11-25 Abbott Laboratories Clip applier and methods of use
US8905937B2 (en) 2009-02-26 2014-12-09 Integrated Vascular Systems, Inc. Methods and apparatus for locating a surface of a body lumen
US8920442B2 (en) 2005-08-24 2014-12-30 Abbott Vascular Inc. Vascular opening edge eversion methods and apparatuses
US8926656B2 (en) 2003-01-30 2015-01-06 Integated Vascular Systems, Inc. Clip applier and methods of use
US8926633B2 (en) 2005-06-24 2015-01-06 Abbott Laboratories Apparatus and method for delivering a closure element
US9089311B2 (en) 2009-01-09 2015-07-28 Abbott Vascular Inc. Vessel closure devices and methods
US9089674B2 (en) 2000-10-06 2015-07-28 Integrated Vascular Systems, Inc. Apparatus and methods for positioning a vascular sheath
US9131941B2 (en) 2011-06-17 2015-09-15 Curaseal Inc. Fistula treatment devices and methods
US9149276B2 (en) 2011-03-21 2015-10-06 Abbott Cardiovascular Systems, Inc. Clip and deployment apparatus for tissue closure
US9173644B2 (en) 2009-01-09 2015-11-03 Abbott Vascular Inc. Closure devices, systems, and methods
US9282965B2 (en) 2008-05-16 2016-03-15 Abbott Laboratories Apparatus and methods for engaging tissue
US9314230B2 (en) 2009-01-09 2016-04-19 Abbott Vascular Inc. Closure device with rapidly eroding anchor
US9332976B2 (en) 2011-11-30 2016-05-10 Abbott Cardiovascular Systems, Inc. Tissue closure device
US9364209B2 (en) 2012-12-21 2016-06-14 Abbott Cardiovascular Systems, Inc. Articulating suturing device
US9414820B2 (en) 2009-01-09 2016-08-16 Abbott Vascular Inc. Closure devices, systems, and methods
US9414824B2 (en) 2009-01-16 2016-08-16 Abbott Vascular Inc. Closure devices, systems, and methods
US9456811B2 (en) 2005-08-24 2016-10-04 Abbott Vascular Inc. Vascular closure methods and apparatuses
US9486191B2 (en) 2009-01-09 2016-11-08 Abbott Vascular, Inc. Closure devices
US9579091B2 (en) 2000-01-05 2017-02-28 Integrated Vascular Systems, Inc. Closure system and methods of use
US9585647B2 (en) 2009-08-26 2017-03-07 Abbott Laboratories Medical device for repairing a fistula
US9993235B2 (en) 2008-09-04 2018-06-12 Curaseal Inc. Enteric fistula treatment devices
US10154835B2 (en) 2013-05-09 2018-12-18 Essential Medical, Inc. Vascular closure device with conforming plug member
US10448938B2 (en) 2016-06-16 2019-10-22 Phillips Medical, LLC Methods and systems for sealing a puncture of a vessel
US10624620B2 (en) 2017-05-12 2020-04-21 Phillips Medical, LLC Systems and methods for sealing a puncture of a vessel
US10716551B2 (en) 2017-05-12 2020-07-21 Phillips Medical, LLC Systems and methods for sealing a puncture of a vessel
US20200237354A1 (en) * 2015-06-30 2020-07-30 Unity Health Toronto Cardiac injury device
US11395658B2 (en) * 2014-07-11 2022-07-26 Cardio Medical Solutions, Inc. Device and method for assisting end-to-side anastomosis
US11744576B2 (en) 2005-06-20 2023-09-05 Scarab Technology Services, Llc Method and apparatus for applying a knot to a suture
US11779324B2 (en) 2013-12-06 2023-10-10 Med-Venture Investments, Llc Suturing methods and apparatuses

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10492936B2 (en) 2015-10-30 2019-12-03 Ram Medical Innovations, Llc Apparatus and method for improved access of procedural catheter in tortuous vessels
US10173031B2 (en) 2016-06-20 2019-01-08 Mubin I. Syed Interchangeable flush/selective catheter
US10857014B2 (en) 2018-02-18 2020-12-08 Ram Medical Innovations, Llc Modified fixed flat wire bifurcated catheter and its application in lower extremity interventions

Citations (104)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1088393A (en) * 1913-09-20 1914-02-24 Oscar E Backus Button.
US1331401A (en) * 1919-09-12 1920-02-17 Summers Henry Clay Button-fastening
US1480935A (en) * 1922-04-03 1924-01-15 Dora P Gleason Barrette
US2583625A (en) * 1946-10-29 1952-01-29 Thomas & Betts Corp Method of and tool for crimping tubes
US2969867A (en) * 1952-08-12 1961-01-31 Filper Corp Fruit transfer apparatus
US3015403A (en) * 1959-04-08 1962-01-02 American Thermos Products Comp Threaded stopper expanding pouring lip combination for vacuum bottle
US3120230A (en) * 1960-10-24 1964-02-04 Jack H Sanders Surgical clamp
US3494533A (en) * 1966-10-10 1970-02-10 United States Surgical Corp Surgical stapler for stitching body organs
US3939820A (en) * 1974-10-29 1976-02-24 Datascope Corporation Single-chamber, multi-section balloon for cardiac assistance
US4007743A (en) * 1975-10-20 1977-02-15 American Hospital Supply Corporation Opening mechanism for umbrella-like intravascular shunt defect closure device
US4189808A (en) * 1978-09-20 1980-02-26 Brown Theodore G Retainer and closure for a garbage can liner bag
US4368736A (en) * 1980-11-17 1983-01-18 Kaster Robert L Anastomotic fitting
US4428376A (en) * 1980-05-02 1984-01-31 Ethicon Inc. Plastic surgical staple
US4635634A (en) * 1985-07-12 1987-01-13 Santos Manuel V Surgical clip applicator system
US4719917A (en) * 1987-02-17 1988-01-19 Minnesota Mining And Manufacturing Company Surgical staple
US4724840A (en) * 1982-02-03 1988-02-16 Ethicon, Inc. Surgical fastener applier with rotatable front housing and laterally extending curved needle for guiding a flexible pusher
US4890612A (en) * 1987-02-17 1990-01-02 Kensey Nash Corporation Device for sealing percutaneous puncture in a vessel
US4902508A (en) * 1988-07-11 1990-02-20 Purdue Research Foundation Tissue graft composition
US4983176A (en) * 1989-03-06 1991-01-08 University Of New Mexico Deformable plastic surgical clip
US5078731A (en) * 1990-06-05 1992-01-07 Hayhurst John O Suture clip
US5176648A (en) * 1991-12-13 1993-01-05 Unisurge, Inc. Introducer assembly and instrument for use therewith
US5275616A (en) * 1990-10-01 1994-01-04 Quinton Instrument Company Insertion assembly and method of inserting a vessel plug into the body of a patient
US5281422A (en) * 1991-09-24 1994-01-25 Purdue Research Foundation Graft for promoting autogenous tissue growth
US5282808A (en) * 1992-05-26 1994-02-01 Origin Medsystems, Inc. Closure prevention apparatus for surgical clip applier
US5282827A (en) * 1991-11-08 1994-02-01 Kensey Nash Corporation Hemostatic puncture closure system and method of use
US5383896A (en) * 1993-05-25 1995-01-24 Gershony; Gary Vascular sealing device
US5383897A (en) * 1992-10-19 1995-01-24 Shadyside Hospital Method and apparatus for closing blood vessel punctures
USRE34866E (en) * 1987-02-17 1995-02-21 Kensey Nash Corporation Device for sealing percutaneous puncture in a vessel
US5392978A (en) * 1991-02-08 1995-02-28 United States Surgical Corporation Surgical staple and endoscopic stapler
US5486195A (en) * 1993-07-26 1996-01-23 Myers; Gene Method and apparatus for arteriotomy closure
US5593412A (en) * 1994-03-01 1997-01-14 Cordis Corporation Stent delivery method and apparatus
US5709224A (en) * 1995-06-07 1998-01-20 Radiotherapeutics Corporation Method and device for permanent vessel occlusion
US5713899A (en) * 1995-04-27 1998-02-03 Societe Jbs Sa Cervical cage designed for the performance of intersomatic arthrodesis
US5715987A (en) * 1994-04-05 1998-02-10 Tracor Incorporated Constant width, adjustable grip, staple apparatus and method
US5720755A (en) * 1995-01-18 1998-02-24 Dakov; Pepi Tubular suturing device and methods of use
US5855312A (en) * 1996-07-25 1999-01-05 Toledano; Haviv Flexible annular stapler for closed surgery of hollow organs
US5858082A (en) * 1997-09-15 1999-01-12 Cruz; Hector Gonzalo Self-interlocking reinforcement fibers
US5860991A (en) * 1992-12-10 1999-01-19 Perclose, Inc. Method for the percutaneous suturing of a vascular puncture site
US5861003A (en) * 1996-10-23 1999-01-19 The Cleveland Clinic Foundation Apparatus and method for occluding a defect or aperture within body surface
US5861005A (en) * 1997-02-11 1999-01-19 X-Site, L.L.C. Arterial stapling device
US5868763A (en) * 1996-09-16 1999-02-09 Guidant Corporation Means and methods for performing an anastomosis
US5868755A (en) * 1997-01-16 1999-02-09 Atrion Medical Products, Inc. Sheath retractor mechanism and method
US5868762A (en) * 1997-09-25 1999-02-09 Sub-Q, Inc. Percutaneous hemostatic suturing device and method
US5871501A (en) * 1994-01-18 1999-02-16 Datascope Investment Corp. Guide wire with releasable barb anchor
US5871474A (en) * 1995-05-19 1999-02-16 General Surgical Innovations, Inc. Screw-type skin seal with inflatable membrane
US5871525A (en) * 1992-04-13 1999-02-16 Ep Technologies, Inc. Steerable ablation catheter system
US5873876A (en) * 1996-09-23 1999-02-23 Christy; William J. Surgical loop delivery device and method
US5873891A (en) * 1994-12-14 1999-02-23 Influence Medical Technologies, Ltd. Staple and thread assembly particularly for use in power-driven staplers for medical suturing
US6010517A (en) * 1996-04-10 2000-01-04 Baccaro; Jorge Alberto Device for occluding abnormal vessel communications
US6013084A (en) * 1995-06-30 2000-01-11 Target Therapeutics, Inc. Stretch resistant vaso-occlusive coils (II)
US6015815A (en) * 1997-09-26 2000-01-18 Abbott Laboratories Tetrazole-containing rapamycin analogs with shortened half-lives
US6019779A (en) * 1998-10-09 2000-02-01 Intratherapeutics Inc. Multi-filar coil medical stent
US6024750A (en) * 1997-08-14 2000-02-15 United States Surgical Ultrasonic curved blade
US6171277B1 (en) * 1997-12-01 2001-01-09 Cordis Webster, Inc. Bi-directional control handle for steerable catheter
US6171329B1 (en) * 1994-12-19 2001-01-09 Gore Enterprise Holdings, Inc. Self-expanding defect closure device and method of making and using
US6174322B1 (en) * 1997-08-08 2001-01-16 Cardia, Inc. Occlusion device for the closure of a physical anomaly such as a vascular aperture or an aperture in a septum
US6179860B1 (en) * 1998-08-19 2001-01-30 Artemis Medical, Inc. Target tissue localization device and method
US6179849B1 (en) * 1999-06-10 2001-01-30 Vascular Innovations, Inc. Sutureless closure for connecting a bypass graft to a target vessel
US6334865B1 (en) * 1998-08-04 2002-01-01 Fusion Medical Technologies, Inc. Percutaneous tissue track closure assembly and method
US20020183787A1 (en) * 2001-06-01 2002-12-05 Velocimed, L.L.C. Closure devices, related delivery methods and tools, and related methods of use
US20020198562A1 (en) * 2000-04-19 2002-12-26 Radi Medical Systems Ab Reinforced absorbable medical sealing device
US20030004543A1 (en) * 1996-10-17 2003-01-02 Malachy Gleeson Device for closure of puncture wound
US20030009180A1 (en) * 1999-09-13 2003-01-09 Hinchliffe Peter W.J. Vascular hole closure device
US6506210B1 (en) * 2000-09-01 2003-01-14 Angiolink Corporation Wound site management and wound closure device
US6508828B1 (en) * 2000-11-03 2003-01-21 Radi Medical Systems Ab Sealing device and wound closure device
US20030018358A1 (en) * 1999-06-25 2003-01-23 Vahid Saadat Apparatus and methods for treating tissue
US20030023248A1 (en) * 1998-03-13 2003-01-30 Parodi Juan C. Systems and methods for applying a suture within a blood vesel lumen
US20030060846A1 (en) * 2001-06-15 2003-03-27 Radi Medical Systems Ab Tamping mechanism
US20030093108A1 (en) * 2001-11-15 2003-05-15 Ernesto Avellanet Aneurysm neck cover for sealing an aneurysm
US6626919B1 (en) * 1997-12-29 2003-09-30 Lee L. Swanstrom Method and apparatus for attaching or locking an implant to an anatomic vessel or hollow organ wall
US6673083B1 (en) * 1999-11-29 2004-01-06 General Surgical Innovations, Inc. Method for blood vessel clip application
US6676685B2 (en) * 1999-02-22 2004-01-13 Tyco Healthcare Group Lp Arterial hole closure apparatus
US6676671B2 (en) * 1998-09-15 2004-01-13 United States Surgical Stapling apparatus and method for heart valve replacement
US20040009289A1 (en) * 2000-12-07 2004-01-15 Carley Michael T. Closure device and methods for making and using them
US20040009205A1 (en) * 1998-08-14 2004-01-15 Incept Llc Methods of using in situ hydration of hydrogel articles for sealing or augmentation of tissue or vessels
US6685707B2 (en) * 2001-09-25 2004-02-03 Walter Lorenz Surgical, Inc. Cranial clamp and method for fixating a bone plate
US6837893B2 (en) * 2000-09-01 2005-01-04 Onux Medical, Inc. Multi-fastener surgical apparatus and method
US6837906B2 (en) * 2001-08-03 2005-01-04 Ensure Medical, Inc. Lung assist apparatus and methods for use
US6846319B2 (en) * 2000-12-14 2005-01-25 Core Medical, Inc. Devices for sealing openings through tissue and apparatus and methods for delivering them
US20050203552A1 (en) * 2004-03-11 2005-09-15 Laufer Michael D. Surgical fastening system
US6984238B2 (en) * 1995-02-24 2006-01-10 Gifford Iii Hanson S Devices and methods for performing avascular anastomosis
US6989016B2 (en) * 1998-07-22 2006-01-24 Medtronic Angiolink, Inc. Vascular suction cannula, dilator and surgical stapler
US6989003B2 (en) * 2001-08-31 2006-01-24 Conmed Corporation Obturator and cannula for a trocar adapted for ease of insertion and removal
US20070005093A1 (en) * 2005-07-01 2007-01-04 Cox John A System for tissue dissection and retraction
US20070010853A1 (en) * 2000-10-06 2007-01-11 Integrated Vascular Systems, Inc. Apparatus and methods for positioning a vascular sheath
US20070010854A1 (en) * 2001-06-07 2007-01-11 Christy Cummins Surgical Staple
US7163551B2 (en) * 2001-08-09 2007-01-16 Thomas Anthony Surgical stapling device
US20070021778A1 (en) * 2005-06-24 2007-01-25 Abbott Laboratories Abbott Vascular Devices Apparatus and method for delivering a closure element
US7169164B2 (en) * 2000-09-21 2007-01-30 Atritech, Inc. Apparatus for implanting devices in atrial appendages
US7169158B2 (en) * 1996-07-23 2007-01-30 Tyco Healthcare Group Lp Anastomosis instrument and method for performing same
US20070185530A1 (en) * 2005-09-01 2007-08-09 Chao Chin-Chen Patent foramen ovale closure method
US20080004636A1 (en) * 2005-07-01 2008-01-03 Abbott Laboratories Clip applier and methods of use
US20080004640A1 (en) * 2006-06-28 2008-01-03 Abbott Laboratories Vessel closure device
US7316706B2 (en) * 2003-06-20 2008-01-08 Medtronic Vascular, Inc. Tensioning device, system, and method for treating mitral valve regurgitation
US7316704B2 (en) * 2003-06-04 2008-01-08 Accessclosure, Inc. Occlusion member and tensioner apparatus and methods of their use for sealing a vascular puncture
US20080009794A1 (en) * 2005-04-22 2008-01-10 Accessclosure, Inc. Apparatus and method for temporary hemostasis
US7322995B2 (en) * 2002-09-13 2008-01-29 Damage Control Surgical Technologies, Inc. Method and apparatus for vascular and visceral clipping
US20080091235A1 (en) * 2006-10-11 2008-04-17 Sirota Daniel J Closure device with biomaterial patches
US20080243182A1 (en) * 2007-03-29 2008-10-02 Datascope Investment Corp. Vascular hemostasis device and deployment apparatus
US7645285B2 (en) * 2004-05-26 2010-01-12 Idx Medical, Ltd Apparatus and methods for occluding a hollow anatomical structure
US20100042144A1 (en) * 2008-08-12 2010-02-18 Steven Bennett Medical Device for Wound Closure and Method of Use
US7867249B2 (en) * 2003-01-30 2011-01-11 Integrated Vascular Systems, Inc. Clip applier and methods of use
US8103327B2 (en) * 2007-12-28 2012-01-24 Rhythmia Medical, Inc. Cardiac mapping catheter
US8105352B2 (en) * 2004-12-16 2012-01-31 Radi Medical Systems Ab Medical sealing device

Family Cites Families (828)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US438400A (en) 1890-10-14 Connector for electric conductors
US287046A (en) 1883-10-23 Combined cork and screw nozzle
US556082A (en) 1896-03-10 Julius boeddinghaus
US1123290A (en) 1914-05-12 1915-01-05 Otto Von Herff Surgical clip.
US1596004A (en) 1923-04-04 1926-08-17 Bengoa Miguel Becerro De Hypodermic syringe
US1647958A (en) 1926-11-02 1927-11-01 Ariberto E Ciarlante Hair-curling material and method of preparing the same
US1880569A (en) 1930-09-27 1932-10-04 John P Weis Surgical clip applying instrument
US2087074A (en) 1936-08-17 1937-07-13 Tucker Ralph Button
US2210061A (en) 1939-01-24 1940-08-06 Aircraft Screw Prod Co Inserting tool
US2254620A (en) 1939-11-14 1941-09-02 George I Miller Clip
US2371978A (en) 1941-12-13 1945-03-20 Roy G Perham Clamp for retaining the edges of a wound in apposition
US2316297A (en) 1943-01-15 1943-04-13 Beverly A Southerland Surgical instrument
US2453227A (en) 1946-09-21 1948-11-09 George Martin Button staple anchor and shield
US2910067A (en) 1952-10-13 1959-10-27 Technical Oil Tool Corp Wound clip and extractor therefor
US2684070A (en) 1953-03-23 1954-07-20 Walter L Kelsey Surgical clip
US2755699A (en) 1953-07-16 1956-07-24 Heli Coil Corp Wire coil screw thread insert with grip end having an angular configuration
US2951482A (en) 1955-09-22 1960-09-06 Gregory B Sullivan Surgical saw
US3113379A (en) 1956-02-28 1963-12-10 Joseph J Frank Closure fastening
US2944311A (en) 1956-10-20 1960-07-12 Schneckenberger Adolf Detachable fastening device
US2969887A (en) 1959-04-08 1961-01-31 American Thermos Products Comp Threaded pouring lip stopper combination for vacuum bottle
US3209754A (en) 1961-08-10 1965-10-05 Ernest C Wood Surgical clip
US3142878A (en) 1963-04-10 1964-08-04 James V Santora Staple button fastener
US3482428A (en) 1967-07-12 1969-12-09 Nikolai Nikolaevich Kapitanov Surgical apparatus for suturing tissues with metal staples
US3523351A (en) 1967-10-20 1970-08-11 Sargent & Co Locator and holder in a crimping tool for an electrical connector
US3586002A (en) 1968-01-08 1971-06-22 Ernest C Wood Surgical skin clip
US3510923A (en) 1968-06-20 1970-05-12 American Hospital Supply Corp Parallel jaw ratchet clip and retractor
US3604425A (en) 1969-04-11 1971-09-14 New Research And Dev Lab Inc Hemostatic clip
US3618447A (en) 1969-09-15 1971-11-09 Phillips Petroleum Co Deterioration fasteners
US3757629A (en) 1971-05-10 1973-09-11 R Schneider Resilient plastic staple
BE789131A (en) 1971-09-24 1973-03-22 Extracorporeal Med Spec SURGICAL NEEDLE FOR PERFORMING MEDICAL OPERATIONS
US3985138A (en) 1972-08-25 1976-10-12 Jarvik Robert K Preformed ligatures for bleeders and methods of applying such ligatures
US3856016A (en) 1972-11-03 1974-12-24 H Davis Method for mechanically applying an occlusion clip to an anatomical tubular structure
US3823719A (en) 1972-11-14 1974-07-16 Acme United Corp Finger operated forceps type surgical instrument
GB1358466A (en) 1972-11-22 1974-07-03 Vnii Ispytatel Med Tech Surgical instrument for stitching tissue with suture wire
US3874388A (en) 1973-02-12 1975-04-01 Ochsner Med Found Alton Shunt defect closure system
US3828791A (en) 1973-03-21 1974-08-13 M Santos Surgical instruments
US3805337A (en) 1973-04-23 1974-04-23 Raymond Lee Organization Inc Spring wire hose clamp
SU495067A1 (en) 1973-06-21 1975-12-15 Новосибирский научно-исследовательский институт патологии кровообращения Patch to close the interventricular heart defects
GB1413191A (en) 1973-07-04 1975-11-12 Vnii Khirurgicheskoi Apparatur Device for the eversion of hollow organs and vascular stapling instrument incorporating same
NL7403762A (en) 1974-03-20 1975-09-23 Leer Koninklijke Emballage STOP OF PLASTIC OR SIMILAR MATERIAL, WITH EXTERNAL THREADS.
US3926194A (en) 1974-11-20 1975-12-16 Ethicon Inc Sutures with reduced diameter at suture tip
US4018228A (en) 1975-02-24 1977-04-19 Goosen Carl C Surgical punch apparatus
US3960147A (en) 1975-03-10 1976-06-01 Murray William M Compression bone staples and methods of compressing bone segments
GB1486351A (en) 1975-06-06 1977-09-21 Rocket Of London Ltd Surgical clip applicator
US4014492A (en) 1975-06-11 1977-03-29 Senco Products, Inc. Surgical staple
US4359052A (en) 1976-01-26 1982-11-16 Concept Inc. Removable tip cautery
MX144149A (en) 1976-04-28 1981-09-02 Kendall & Co IMPROVED DEVICE TO VERIFY THE POSITION OF A NEEDLE IN THE BODY OF A PATIENT
DE2730691C2 (en) 1976-07-16 1982-12-16 Maruho Co. Ltd., Osaka Surgical clip, connecting element for several surgical clips and forceps for opening and closing the same
US4047533A (en) 1976-09-20 1977-09-13 American Cyanamid Company Absorbable surgical sutures coated with polyoxyethylene-polyoxypropylene copolymer lubricant
US4112944A (en) 1976-12-13 1978-09-12 Williams Gayland M Tube clamp and piercing device
DE2658478C2 (en) 1976-12-23 1978-11-30 Aesculap-Werke Ag Vormals Jetter & Scheerer, 7200 Tuttlingen Vascular clips for surgical use
SU715082A1 (en) 1977-01-24 1980-02-15 Всесоюзный научно-исследовательский и испытательный институт медицинской техники Surgical suturing apparatus
US4153321A (en) 1977-03-17 1979-05-08 Kravex Manufacturing Company Battery booster cable
US4217902A (en) 1977-05-02 1980-08-19 March Alfred L Hemostatic clip
US4169476A (en) 1977-08-12 1979-10-02 Wolf Medical Instruments Corporation Applicator for surgical clip
US4201215A (en) 1977-09-06 1980-05-06 Crossett E S Apparatus and method for closing a severed sternum
US4345606A (en) 1977-12-13 1982-08-24 Littleford Philip O Split sleeve introducers for pacemaker electrodes and the like
US4900303A (en) 1978-03-10 1990-02-13 Lemelson Jerome H Dispensing catheter and method
US4215699A (en) 1978-04-03 1980-08-05 The Kendall Company Position indicating device
US4207870A (en) 1978-06-15 1980-06-17 Becton, Dickinson And Company Blood sampling assembly having porous vent means vein entry indicator
US4273129A (en) 1978-06-29 1981-06-16 Richard Wolf Gmbh Forceps for applying clips to fallopian tubes
USRE31855F1 (en) 1978-12-01 1986-08-19 Tear apart cannula
SU886898A1 (en) 1978-12-08 1981-12-07 Всесоюзный научно-исследовательский и испытательный институт медицинской техники Surgical suturing apparatus
US4214587A (en) 1979-02-12 1980-07-29 Sakura Chester Y Jr Anastomosis device and method
US4440170A (en) 1979-03-06 1984-04-03 Ethicon, Inc. Surgical clip applying instrument
US4278091A (en) 1980-02-01 1981-07-14 Howmedica, Inc. Soft tissue retainer for use with bone implants, especially bone staples
US4396139A (en) 1980-02-15 1983-08-02 Technalytics, Inc. Surgical stapling system, apparatus and staple
US4317451A (en) 1980-02-19 1982-03-02 Ethicon, Inc. Plastic surgical staple
US4317445A (en) 1980-03-31 1982-03-02 Baxter Travenol Laboratories, Inc. Catheter insertion unit with separate flashback indication for the cannula
US4318401A (en) 1980-04-24 1982-03-09 President And Fellows Of Harvard College Percutaneous vascular access portal and catheter
FR2481594A1 (en) 1980-05-02 1981-11-06 Ethicon Inc PERFECTED PLASTIC SURGICAL STAPLE
US4327485A (en) 1980-05-21 1982-05-04 Amp Incorporated Pistol grip tool
SU912155A1 (en) 1980-07-31 1982-03-15 Крымский Медицинский Институт Device for closure of wounds
CA1170536A (en) 1980-08-25 1984-07-10 United States Surgical Corporation Surgical staples
US4505274A (en) 1980-10-17 1985-03-19 Propper Manufacturing Co., Inc. Suture clip
US4526174A (en) 1981-03-27 1985-07-02 Minnesota Mining And Manufacturing Company Staple and cartridge for use in a tissue stapling device and a tissue closing method
US4412832A (en) 1981-04-30 1983-11-01 Baxter Travenol Laboratories, Inc. Peelable catheter introduction device
US4411654A (en) 1981-04-30 1983-10-25 Baxter Travenol Laboratories, Inc. Peelable catheter with securing ring and suture sleeve
US4485816A (en) 1981-06-25 1984-12-04 Alchemia Shape-memory surgical staple apparatus and method for use in surgical suturing
US4449531A (en) 1981-08-27 1984-05-22 Ethicon, Inc. Non-metallic, bio-compatible hemostatic clips with interlocking latch means
US4570633A (en) 1981-09-28 1986-02-18 Ethicon, Inc. Surgical clip applier instrument adapter jaws
US4480356A (en) 1981-10-07 1984-11-06 Martin Donald A Double-grip clip
DE3204532C2 (en) 1982-02-10 1983-12-08 B. Braun Melsungen Ag, 3508 Melsungen Surgical skin staple
DE3204522A1 (en) 1982-02-10 1983-08-25 B. Braun Melsungen Ag, 3508 Melsungen SURGICAL SKIN CLIP DEVICE
US4475544A (en) 1982-02-23 1984-10-09 Reis Norman I Bone gripping forceps
US4860746A (en) 1982-04-20 1989-08-29 Inbae Yoon Elastic surgical ring clip and ring loader
US4664305A (en) 1982-05-04 1987-05-12 Blake Joseph W Iii Surgical stapler
JPS58181006U (en) 1982-05-28 1983-12-03 佐藤 定行 staple
US4492232A (en) 1982-09-30 1985-01-08 United States Surgical Corporation Surgical clip applying apparatus having fixed jaws
US4523591A (en) 1982-10-22 1985-06-18 Kaplan Donald S Polymers for injection molding of absorbable surgical devices
US4525157A (en) 1983-07-28 1985-06-25 Manresa, Inc. Closed system catheter with guide wire
DE3473989D1 (en) 1983-10-13 1988-10-20 Morgenstern Jurgen Physiological sensor
US4665906A (en) 1983-10-14 1987-05-19 Raychem Corporation Medical devices incorporating sim alloy elements
US4586503A (en) 1983-12-01 1986-05-06 University Of New Mexico Surgical microclip
US4929240A (en) 1983-12-01 1990-05-29 University Of New Mexico Surgical clip and applier
US6221102B1 (en) 1983-12-09 2001-04-24 Endovascular Technologies, Inc. Intraluminal grafting system
US5104399A (en) 1986-12-10 1992-04-14 Endovascular Technologies, Inc. Artificial graft and implantation method
US4917087A (en) 1984-04-10 1990-04-17 Walsh Manufacturing (Mississuaga) Limited Anastomosis devices, kits and method
US4607638A (en) 1984-04-20 1986-08-26 Design Standards Corporation Surgical staples
DE3420455C1 (en) 1984-06-01 1985-05-15 Peter Dr.-Ing. 7889 Grenzach-Wyhlen Osypka Separating device for an insertion sleeve
US4610252A (en) 1984-10-15 1986-09-09 Catalano J Denis Dual muscle clamp
US4651737A (en) 1984-10-15 1987-03-24 American Cyanamid Company Nonmetallic surgical clip
US4596559A (en) 1984-11-02 1986-06-24 Fleischhacker John J Break-away handle for a catheter introducer set
SU1243708A1 (en) 1985-02-04 1986-07-15 Научно-производственное объединение "Мединструмент" Arrangement for bringing wound edges closer
US4610251A (en) 1985-04-19 1986-09-09 Kumar Sarbjeet S Surgical staple
CN85106639B (en) 1985-09-03 1988-08-03 第三军医大学野战外科研究所 Instrument for blood vessel anastomosis
DE3533423A1 (en) 1985-09-19 1987-03-26 Wolf Gmbh Richard APPLICATOR PLIERS FOR SURGICAL HANDLING FOR USE IN ENDOSCOPY
SU1324650A1 (en) 1986-01-03 1987-07-23 Харьковский научно-исследовательский институт общей и неотложной хирургии Arrangement for providing hemostasis with the heart wounded
US4693249A (en) 1986-01-10 1987-09-15 Schenck Robert R Anastomosis device and method
JPS62236560A (en) 1986-04-09 1987-10-16 テルモ株式会社 Catheter for repairing blood vessel
US4777950A (en) 1986-04-11 1988-10-18 Kees Surgical Specialty Co. Vascular clip
US4967949A (en) 1986-07-11 1990-11-06 Vastech Medical Products Inc. Apparatus for effecting occlusion of the vas deferens
US4874122A (en) 1986-07-14 1989-10-17 Minnesota Mining And Manufacturing Company Bent back box staple and staple closing mechanism with split actuator
SU1456109A1 (en) 1986-07-23 1989-02-07 Сибирский физико-технический институт им.В.Д.Кузнецова при Томском государственном университете Arrangement for bringing together the wound edges
SU1405828A1 (en) 1986-09-17 1988-06-30 Запорожский Областной Отдел Здравоохранения Arrangement for osteosynthesis of fractures of skull flat bones
US4738658A (en) 1986-09-19 1988-04-19 Aries Medical Incorporated Tapered hemostatic device for use in conjunction with a catheter for alleviating blood leakage and method for using same
US4789090A (en) 1986-11-03 1988-12-06 Blake Joseph W Iii Surgical stapler
US4771782A (en) 1986-11-14 1988-09-20 Millar Instruments, Inc. Method and assembly for introducing multiple catheters into a biological vessel
US4834757A (en) 1987-01-22 1989-05-30 Brantigan John W Prosthetic implant
US4744364A (en) 1987-02-17 1988-05-17 Intravascular Surgical Instruments, Inc. Device for sealing percutaneous puncture in a vessel
US4852568A (en) 1987-02-17 1989-08-01 Kensey Nash Corporation Method and apparatus for sealing an opening in tissue of a living being
US4865026A (en) 1987-04-23 1989-09-12 Barrett David M Sealing wound closure device
US4772266A (en) 1987-05-04 1988-09-20 Catheter Technology Corp. Catheter dilator/sheath assembly and method
US5478353A (en) 1987-05-14 1995-12-26 Yoon; Inbae Suture tie device system and method for suturing anatomical tissue proximate an opening
US5171250A (en) 1987-05-14 1992-12-15 Inbae Yoon Surgical clips and surgical clip applicator and cutting and transection device
US5366459A (en) 1987-05-14 1994-11-22 Inbae Yoon Surgical clip and clip application procedures
US5100418A (en) 1987-05-14 1992-03-31 Inbae Yoon Suture tie device system and applicator therefor
US5011487A (en) 1987-06-24 1991-04-30 United States Surgical Corporation Vascular clamp assembly
US4836204A (en) 1987-07-06 1989-06-06 Landymore Roderick W Method for effecting closure of a perforation in the septum of the heart
SU1616624A1 (en) 1987-07-14 1990-12-30 Предприятие П/Я А-3697 Surgical suturing apparatus
US5061283A (en) 1987-10-30 1991-10-29 Pfizer Hospital Products Group, Inc. Method for tendon and ligament repair
US4887601A (en) 1987-11-06 1989-12-19 Ophthalmic Ventures Limited Partnership Adjustable surgical staple and method of using the same
US5510115A (en) 1987-11-16 1996-04-23 Baxter Travenol Laboratories, Inc. Method and composition for administration of beneficial agent by controlled dissolution
US5030226A (en) 1988-01-15 1991-07-09 United States Surgical Corporation Surgical clip applicator
JP2561853B2 (en) 1988-01-28 1996-12-11 株式会社ジェイ・エム・エス Shaped memory molded article and method of using the same
US5114065A (en) 1988-05-23 1992-05-19 Technalytics, Inc. Surgical stapler
US5330445A (en) 1988-05-26 1994-07-19 Haaga John R Sheath for wound closure caused by a medical tubular device
US5254105A (en) 1988-05-26 1993-10-19 Haaga John R Sheath for wound closure caused by a medical tubular device
CA2004658C (en) 1988-06-03 1995-10-10 Michael A. Oberlander Arthroscopic clip and insertion tool
US5002562A (en) 1988-06-03 1991-03-26 Oberlander Michael A Surgical clip
US5015247A (en) 1988-06-13 1991-05-14 Michelson Gary K Threaded spinal implant
SU1560133A1 (en) 1988-07-11 1990-04-30 Сибирский Физико-Технический Институт При Томском Государственном Университете Им.В.В.Куйбышева Device for connecting lips of wound
US4885003A (en) 1988-07-25 1989-12-05 Cordis Corporation Double mesh balloon catheter device
US4917089A (en) 1988-08-29 1990-04-17 Sideris Eleftherios B Buttoned device for the transvenous occlusion of intracardiac defects
US5167643A (en) 1990-04-27 1992-12-01 Lynn Lawrence A Needle protection station
IE893270L (en) 1988-10-11 1990-04-11 Seamus Geoghegan Ophthalmic staple and instruments for implementing use
US5047047A (en) 1988-10-26 1991-09-10 Inbae Yoon Wound closing device
US4961729A (en) 1988-12-13 1990-10-09 Vaillancourt Vincent L Catheter insertion assembly
US4976721A (en) 1988-12-14 1990-12-11 The Research Foundation Of State University Of New York Surgical clamping device
US4886067A (en) 1989-01-03 1989-12-12 C. R. Bard, Inc. Steerable guidewire with soft adjustable tip
FR2641692A1 (en) 1989-01-17 1990-07-20 Nippon Zeon Co Plug for closing an opening for a medical application, and device for the closure plug making use thereof
US4997439A (en) 1989-01-26 1991-03-05 Chen Fusen H Surgical closure or anastomotic device
JPH07103457B2 (en) 1989-02-10 1995-11-08 トミー株式会社 Shape memory alloy straightening wire
US5053047A (en) 1989-05-16 1991-10-01 Inbae Yoon Suture devices particularly useful in endoscopic surgery and methods of suturing
US5100422A (en) 1989-05-26 1992-03-31 Impra, Inc. Blood vessel patch
US5620461A (en) 1989-05-29 1997-04-15 Muijs Van De Moer; Wouter M. Sealing device
US5007921A (en) 1989-10-26 1991-04-16 Brown Alan W Surgical staple
US5026390A (en) 1989-10-26 1991-06-25 Brown Alan W Surgical staple
US5059201A (en) 1989-11-03 1991-10-22 Asnis Stanley E Suture threading, stitching and wrapping device for use in open and closed surgical procedures
GB8924806D0 (en) 1989-11-03 1989-12-20 Neoligaments Ltd Prosthectic ligament system
US5122122A (en) 1989-11-22 1992-06-16 Dexide, Incorporated Locking trocar sleeve
US5061274A (en) 1989-12-04 1991-10-29 Kensey Nash Corporation Plug device for sealing openings and method of use
CA2122041A1 (en) 1989-12-04 1993-04-29 Kenneth Kensey Plug device for sealing openings and method of use
US5797958A (en) 1989-12-05 1998-08-25 Yoon; Inbae Endoscopic grasping instrument with scissors
US5226908A (en) 1989-12-05 1993-07-13 Inbae Yoon Multi-functional instruments and stretchable ligating and occluding devices
GB8928196D0 (en) 1989-12-13 1990-02-14 Merrell Dow Pharmaceuticals Li Pharmaceutical lozenges
US5421832A (en) 1989-12-13 1995-06-06 Lefebvre; Jean-Marie Filter-catheter and method of manufacturing same
US5156609A (en) 1989-12-26 1992-10-20 Nakao Naomi L Endoscopic stapling device and method
US5891088A (en) 1990-02-02 1999-04-06 Ep Technologies, Inc. Catheter steering assembly providing asymmetric left and right curve configurations
US5035692A (en) 1990-02-13 1991-07-30 Nicholas Herbert Hemostasis clip applicator
US5197971A (en) 1990-03-02 1993-03-30 Bonutti Peter M Arthroscopic retractor and method of using the same
US5032127A (en) 1990-03-07 1991-07-16 Frazee John G Hemostatic clip and applicator therefor
US5171259A (en) 1990-04-02 1992-12-15 Kanji Inoue Device for nonoperatively occluding a defect
US5021059A (en) 1990-05-07 1991-06-04 Kensey Nash Corporation Plug device with pulley for sealing punctures in tissue and methods of use
DE4014653A1 (en) 1990-05-08 1991-11-14 Beiersdorf Ag SURGICAL CLAMP
US5116349A (en) 1990-05-23 1992-05-26 United States Surgical Corporation Surgical fastener apparatus
US5041129A (en) 1990-07-02 1991-08-20 Acufex Microsurgical, Inc. Slotted suture anchor and method of anchoring a suture
US5193533A (en) 1990-07-09 1993-03-16 Brigham And Women's Hospital High-pressure jet ventilation catheter
US7008439B1 (en) 1990-09-21 2006-03-07 Datascope Investments Corp. Device and method for sealing puncture wounds
US5391183A (en) 1990-09-21 1995-02-21 Datascope Investment Corp Device and method sealing puncture wounds
US5192300A (en) 1990-10-01 1993-03-09 Quinton Instrument Company Insertion assembly and method of inserting a vessel plug into the body of a patient
CA2027427A1 (en) 1990-10-12 1992-04-13 William S. Laidlaw Plug for sealing wood preservative in wood structures
US5042707A (en) 1990-10-16 1991-08-27 Taheri Syde A Intravascular stapler, and method of operating same
FR2668361A1 (en) 1990-10-30 1992-04-30 Mai Christian OSTEOSYNTHESIS CLIP AND PLATE WITH SELF-RETENTIVE DYNAMIC COMPRESSION.
US5053008A (en) 1990-11-21 1991-10-01 Sandeep Bajaj Intracardiac catheter
US5366458A (en) 1990-12-13 1994-11-22 United States Surgical Corporation Latchless surgical clip
US5122156A (en) 1990-12-14 1992-06-16 United States Surgical Corporation Apparatus for securement and attachment of body organs
US5425489A (en) 1990-12-20 1995-06-20 United States Surgical Corporation Fascia clip and instrument
CA2055985A1 (en) 1990-12-20 1992-06-21 Daniel Shichman Fascia clip
US5419765A (en) 1990-12-27 1995-05-30 Novoste Corporation Wound treating device and method for treating wounds
US5250058A (en) 1991-01-17 1993-10-05 Ethicon, Inc. Absorbable anastomosic fastener means
US5131379A (en) 1991-01-29 1992-07-21 Sewell Jr Frank K Device and method for inserting a cannula into a duct
US5108420A (en) 1991-02-01 1992-04-28 Temple University Aperture occlusion device
US5470010A (en) 1991-04-04 1995-11-28 Ethicon, Inc. Multiple fire endoscopic stapling mechanism
US5246156A (en) 1991-09-12 1993-09-21 Ethicon, Inc. Multiple fire endoscopic stapling mechanism
US5171249A (en) 1991-04-04 1992-12-15 Ethicon, Inc. Endoscopic multiple ligating clip applier
AR244071A1 (en) 1991-09-05 1993-10-29 Groiso Jorge Abel An elastic staple for osteosynthesis and a tool for placing it.
US5192602A (en) 1991-05-14 1993-03-09 Spencer Victor V Louvered filter and paint arrestor
US5243857A (en) 1991-06-14 1993-09-14 Molex Incorporated Fixture for testing electrical terminations
US5207697A (en) 1991-06-27 1993-05-04 Stryker Corporation Battery powered surgical handpiece
US5735290A (en) 1993-02-22 1998-04-07 Heartport, Inc. Methods and systems for performing thoracoscopic coronary bypass and other procedures
US5236435A (en) 1991-07-22 1993-08-17 Sewell Jr Frank Laparoscopic surgical staple system
US5167634A (en) 1991-08-22 1992-12-01 Datascope Investment Corp. Peelable sheath with hub connector
CA2078530A1 (en) 1991-09-23 1993-03-24 Jay Erlebacher Percutaneous arterial puncture seal device and insertion tool therefore
US5497933A (en) 1991-10-18 1996-03-12 United States Surgical Corporation Apparatus and method for applying surgical staples to attach an object to body tissue
US5289963A (en) 1991-10-18 1994-03-01 United States Surgical Corporation Apparatus and method for applying surgical staples to attach an object to body tissue
US5141520A (en) 1991-10-29 1992-08-25 Marlowe Goble E Harpoon suture anchor
US5290310A (en) 1991-10-30 1994-03-01 Howmedica, Inc. Hemostatic implant introducer
EP0545091B1 (en) 1991-11-05 1999-07-07 The Children's Medical Center Corporation Occluder for repair of cardiac and vascular defects
US5222974A (en) 1991-11-08 1993-06-29 Kensey Nash Corporation Hemostatic puncture closure system and method of use
US5676689A (en) 1991-11-08 1997-10-14 Kensey Nash Corporation Hemostatic puncture closure system including vessel location device and method of use
US5411520A (en) 1991-11-08 1995-05-02 Kensey Nash Corporation Hemostatic vessel puncture closure system utilizing a plug located within the puncture tract spaced from the vessel, and method of use
US5242456A (en) 1991-11-21 1993-09-07 Kensey Nash Corporation Apparatus and methods for clamping tissue and reflecting the same
US6056768A (en) 1992-01-07 2000-05-02 Cates; Christopher U. Blood vessel sealing system
DE4200255A1 (en) 1992-01-08 1993-07-15 Sueddeutsche Feinmechanik SPLIT CANNULA AND METHOD FOR PRODUCING SUCH A
US5433721A (en) 1992-01-17 1995-07-18 Ethicon, Inc. Endoscopic instrument having a torsionally stiff drive shaft for applying fasteners to tissue
JP3393383B2 (en) 1992-01-21 2003-04-07 リージェンツ オブ ザ ユニバーシティ オブ ミネソタ Septal defect closure device
US5163343A (en) 1992-02-21 1992-11-17 Gish Donald A System for fastening plies of fabric
US5509900A (en) 1992-03-02 1996-04-23 Kirkman; Thomas R. Apparatus and method for retaining a catheter in a blood vessel in a fixed position
US6059825A (en) 1992-03-05 2000-05-09 Angiodynamics, Inc. Clot filter
CA2090980C (en) 1992-03-06 2004-11-30 David Stefanchik Ligating clip applier
AU3796893A (en) 1992-03-18 1993-10-21 Izi Corporation Post-surgical gross pathology specimen marker
US5304183A (en) 1992-03-23 1994-04-19 Laparomed Corporation Tethered clamp retractor
US5217024A (en) 1992-03-27 1993-06-08 Dorsey Denis P Tissue sampling device with visual and tactile indicator
US5236440A (en) 1992-04-14 1993-08-17 American Cyanamid Company Surgical fastener
WO1993021844A1 (en) 1992-04-23 1993-11-11 Scimed Life Systems, Inc. Apparatus and method for sealing vascular punctures
US6063085A (en) 1992-04-23 2000-05-16 Scimed Life Systems, Inc. Apparatus and method for sealing vascular punctures
US5540712A (en) 1992-05-01 1996-07-30 Nitinol Medical Technologies, Inc. Stent and method and apparatus for forming and delivering the same
US5242457A (en) 1992-05-08 1993-09-07 Ethicon, Inc. Surgical instrument and staples for applying purse string sutures
DE4215449C1 (en) 1992-05-11 1993-09-02 Ethicon Gmbh & Co Kg, 2000 Norderstedt, De
US5766246A (en) 1992-05-20 1998-06-16 C. R. Bard, Inc. Implantable prosthesis and method and apparatus for loading and delivering an implantable prothesis
US5269792A (en) 1992-05-26 1993-12-14 Origin Medsystems, Inc. Surgical clip
US5431667A (en) 1992-05-26 1995-07-11 Origin Medsystems, Inc. Gas-sealed instruments for use in laparoscopic surgery
US5255679A (en) 1992-06-02 1993-10-26 Cardiac Pathways Corporation Endocardial catheter for mapping and/or ablation with an expandable basket structure having means for providing selective reinforcement and pressure sensing mechanism for use therewith, and method
JPH0647050A (en) 1992-06-04 1994-02-22 Olympus Optical Co Ltd Tissue suture and ligature device
US5797931A (en) 1992-06-04 1998-08-25 Olympus Optical Co., Ltd. Tissue-fixing surgical instrument, tissue-fixing device, and method of fixing tissues
US5484420A (en) 1992-07-09 1996-01-16 Wilson-Cook Medical Inc. Retention bolsters for percutaneous catheters
US5242459A (en) 1992-07-10 1993-09-07 Laparomed Corporation Device and method for applying a ligating loop
US5413571A (en) 1992-07-16 1995-05-09 Sherwood Medical Company Device for sealing hemostatic incisions
US5290243A (en) 1992-07-16 1994-03-01 Technalytics, Inc. Trocar system
US5292332A (en) 1992-07-27 1994-03-08 Lee Benjamin I Methods and device for percutanceous sealing of arterial puncture sites
US5443481A (en) 1992-07-27 1995-08-22 Lee; Benjamin I. Methods and device for percutaneous sealing of arterial puncture sites
US5334199A (en) 1992-08-17 1994-08-02 Inbae Yoon Ligating instrument and methods of ligating tissue in endoscopic operative procedures
US5342393A (en) 1992-08-27 1994-08-30 Duke University Method and device for vascular repair
US5364408A (en) 1992-09-04 1994-11-15 Laurus Medical Corporation Endoscopic suture system
US5471982A (en) 1992-09-29 1995-12-05 Ep Technologies, Inc. Cardiac mapping and ablation systems
US5306254A (en) 1992-10-01 1994-04-26 Kensey Nash Corporation Vessel position locating device and method of use
US5304184A (en) 1992-10-19 1994-04-19 Indiana University Foundation Apparatus and method for positive closure of an internal tissue membrane opening
DE4235506A1 (en) 1992-10-21 1994-04-28 Bavaria Med Tech Drug injection catheter
US5309927A (en) 1992-10-22 1994-05-10 Ethicon, Inc. Circular stapler tissue retention spring method
US5676974A (en) 1992-10-23 1997-10-14 Santiago H. Valdes Pharmaceutical compositions containing giroxina and phospholipase A2 and methods of increasing a patient's CD4 count using the pharmaceutical compositions
US5344439A (en) 1992-10-30 1994-09-06 Medtronic, Inc. Catheter with retractable anchor mechanism
US5464416A (en) 1992-11-10 1995-11-07 Ethicon, Inc. Ligating clip
FR2700464B1 (en) 1992-11-13 1995-04-14 Maurice Bertholet Connecting piece for bone elements.
US5972000A (en) 1992-11-13 1999-10-26 Influence Medical Technologies, Ltd. Non-linear anchor inserter device and bone anchors
CZ281454B6 (en) 1992-11-23 1996-10-16 Milan Mudr. Csc. Krajíček Aid for non-surgical closing of a hole in a vessel wall
US20020095164A1 (en) 1997-06-26 2002-07-18 Andreas Bernard H. Device and method for suturing tissue
US5334216A (en) 1992-12-10 1994-08-02 Howmedica Inc. Hemostatic plug
US5284488A (en) * 1992-12-23 1994-02-08 Sideris Eleftherios B Adjustable devices for the occlusion of cardiac defects
US5327908A (en) 1993-01-08 1994-07-12 United States Surgical Corporation Surgical apparatus for measuring body tissue
US5292309A (en) 1993-01-22 1994-03-08 Schneider (Usa) Inc. Surgical depth measuring instrument and method
US5304204A (en) 1993-02-09 1994-04-19 Ethicon, Inc. Receiverless surgical fasteners
US5425705A (en) 1993-02-22 1995-06-20 Stanford Surgical Technologies, Inc. Thoracoscopic devices and methods for arresting the heart
US5797960A (en) 1993-02-22 1998-08-25 Stevens; John H. Method and apparatus for thoracoscopic intracardiac procedures
US5814058A (en) 1993-03-05 1998-09-29 Innerdyne, Inc. Method and apparatus employing conformable sleeve for providing percutaneous access
US5320639A (en) 1993-03-12 1994-06-14 Meadox Medicals, Inc. Vascular plug delivery system
US5843167A (en) 1993-04-22 1998-12-01 C. R. Bard, Inc. Method and apparatus for recapture of hooked endoprosthesis
US5456400A (en) 1993-04-22 1995-10-10 United States Surgical Corporation Apparatus and clip for fastening body tissue
FR2704132B1 (en) 1993-04-23 1995-07-13 Ethnor System for ligature and / or suture for endoscopic surgery.
DE69425453T2 (en) 1993-04-23 2001-04-12 Novartis Ag Drug delivery device with controlled release
US5335680A (en) 1993-04-26 1994-08-09 Moore Pamela K Hair clip
US5447265A (en) 1993-04-30 1995-09-05 Minnesota Mining And Manufacturing Company Laparoscopic surgical instrument with a mechanism for preventing its entry into the abdominal cavity once it is depleted and removed from the abdominal cavity
US5352229A (en) 1993-05-12 1994-10-04 Marlowe Goble E Arbor press staple and washer and method for its use
US5478354A (en) 1993-07-14 1995-12-26 United States Surgical Corporation Wound closing apparatus and method
US5507755A (en) 1993-08-03 1996-04-16 Origin Medsystems, Inc. Apparatus and method for closing puncture wounds
US5462561A (en) 1993-08-05 1995-10-31 Voda; Jan K. Suture device
US5431639A (en) 1993-08-12 1995-07-11 Boston Scientific Corporation Treating wounds caused by medical procedures
US5830125A (en) 1993-08-12 1998-11-03 Scribner-Browne Medical Design Incorporated Catheter introducer with suture capability
FR2710254B1 (en) 1993-09-21 1995-10-27 Mai Christian Multi-branch osteosynthesis clip with self-retaining dynamic compression.
PL171425B1 (en) 1993-09-27 1997-04-30 Przed Uslugowe I Prod Handlowe Method of closing up an open wound and device therefor
US5607436A (en) 1993-10-08 1997-03-04 United States Surgical Corporation Apparatus for applying surgical clips
US5725554A (en) 1993-10-08 1998-03-10 Richard-Allan Medical Industries, Inc. Surgical staple and stapler
US5560532A (en) 1993-10-08 1996-10-01 United States Surgical Corporation Apparatus and method for applying surgical staples to body tissue
WO1995010296A1 (en) 1993-10-12 1995-04-20 Glycomed Incorporated A library of glyco-peptides useful for identification of cell adhesion inhibitors
US5776147A (en) 1993-10-20 1998-07-07 Applied Medical Resources Corporation Laparoscopic surgical clamp
US5423857A (en) 1993-11-02 1995-06-13 Ethicon, Inc. Three piece surgical staple
US5527322A (en) 1993-11-08 1996-06-18 Perclose, Inc. Device and method for suturing of internal puncture sites
US5503635A (en) 1993-11-12 1996-04-02 United States Surgical Corporation Apparatus and method for performing compressional anastomoses
US5464413A (en) 1993-11-15 1995-11-07 Siska, Jr.; William Nose clip
US5476505A (en) 1993-11-18 1995-12-19 Advanced Cardiovascular Systems, Inc. Coiled stent and delivery system
NL194533C (en) 1993-12-08 2002-07-02 Benedict Marie Doorschodt Biopsy needle assembly.
US5609597A (en) 1993-12-09 1997-03-11 Lehrer; Theodor Apparatus and method of extracorporeally applying and locking laparoscopic suture and loop ligatures
WO1995016407A1 (en) 1993-12-13 1995-06-22 Brigham And Women's Hospital Aortic valve supporting device
RU2089131C1 (en) 1993-12-28 1997-09-10 Сергей Апполонович Пульнев Stent-expander
AU1011595A (en) 1994-01-13 1995-07-20 Ethicon Inc. Spiral surgical tack
FR2715290B1 (en) 1994-01-25 1996-04-05 Newpact Eurl Surgical staple with ligaments.
US5443477A (en) 1994-02-10 1995-08-22 Stentco, Inc. Apparatus and method for deployment of radially expandable stents by a mechanical linkage
DE4408108A1 (en) 1994-03-10 1995-09-14 Bavaria Med Tech Catheter for injecting a fluid or a drug
US6117157A (en) 1994-03-18 2000-09-12 Cook Incorporated Helical embolization coil
WO1995026683A1 (en) 1994-03-31 1995-10-12 Boston Scientific Corporation Vascular plug with vessel locator
US5695524A (en) 1994-04-05 1997-12-09 Tracor Aerospace, Inc. Constant width, adjustable grip, staple apparatus and method
US5416584A (en) 1994-04-25 1995-05-16 Honeywell Inc. Sinusoidal noise injection into the dither of a ring laser gyroscope
US5545178A (en) * 1994-04-29 1996-08-13 Kensey Nash Corporation System for closing a percutaneous puncture formed by a trocar to prevent tissue at the puncture from herniating
DE4415521C2 (en) 1994-05-04 2003-01-30 Storz Reling Sybill Gesamthand Instrument for use in endoscopic procedures
US5425740A (en) 1994-05-17 1995-06-20 Hutchinson, Jr.; William B. Endoscopic hernia repair clip and method
US5478309A (en) 1994-05-27 1995-12-26 William P. Sweezer, Jr. Catheter system and method for providing cardiopulmonary bypass pump support during heart surgery
US5732872A (en) 1994-06-17 1998-03-31 Heartport, Inc. Surgical stapling instrument
US6302898B1 (en) 1994-06-24 2001-10-16 Advanced Closure Systems, Inc. Devices for sealing punctures in body vessels
US5725552A (en) 1994-07-08 1998-03-10 Aga Medical Corporation Percutaneous catheter directed intravascular occlusion devices
US5544802A (en) 1994-07-27 1996-08-13 Crainich; Lawrence Surgical staple and stapler device therefor
FR2722975A1 (en) 1994-07-28 1996-02-02 Dynamique Sante Sarl Surgical implant for fastening ligament against bone surface
US5582616A (en) 1994-08-05 1996-12-10 Origin Medsystems, Inc. Surgical helical fastener with applicator
US5972023A (en) 1994-08-15 1999-10-26 Eva Corporation Implantation device for an aortic graft method of treating aortic aneurysm
US5549633A (en) 1994-08-24 1996-08-27 Kensey Nash Corporation Apparatus and methods of use for preventing blood seepage at a percutaneous puncture site
US5496332A (en) 1994-10-20 1996-03-05 Cordis Corporation Wound closure apparatus and method for its use
AU3783195A (en) 1994-11-15 1996-05-23 Advanced Cardiovascular Systems Inc. Intraluminal stent for attaching a graft
CA2301351C (en) 1994-11-28 2002-01-22 Advanced Cardiovascular Systems, Inc. Method and apparatus for direct laser cutting of metal stents
US5879366A (en) 1996-12-20 1999-03-09 W.L. Gore & Associates, Inc. Self-expanding defect closure device and method of making and using
US5620452A (en) 1994-12-22 1997-04-15 Yoon; Inbae Surgical clip with ductile tissue penetrating members
JP3798838B2 (en) 1995-01-20 2006-07-19 オリンパス株式会社 Ligation device
US5634936A (en) 1995-02-06 1997-06-03 Scimed Life Systems, Inc. Device for closing a septal defect
WO1996024291A1 (en) 1995-02-07 1996-08-15 Cardiovascular Ventures, Inc. Puncture sealing system
US5649959A (en) 1995-02-10 1997-07-22 Sherwood Medical Company Assembly for sealing a puncture in a vessel
US5797933A (en) 1996-07-16 1998-08-25 Heartport, Inc. Coronary shunt and method of use
US5695504A (en) 1995-02-24 1997-12-09 Heartport, Inc. Devices and methods for performing a vascular anastomosis
US5695505A (en) 1995-03-09 1997-12-09 Yoon; Inbae Multifunctional spring clips and cartridges and applicators therefor
RU2086192C1 (en) 1995-03-17 1997-08-10 Ялмар Яковлевич Татти Surgical suture appliance
US5575771A (en) 1995-04-24 1996-11-19 Walinsky; Paul Balloon catheter with external guidewire
US5681280A (en) 1995-05-02 1997-10-28 Heart Rhythm Technologies, Inc. Catheter control system
FR2734147B1 (en) 1995-05-19 1997-10-10 Klein Jean Michel IMPLANTABLE OSTEOSYNTHESIS DEVICE
US5755727A (en) 1995-06-02 1998-05-26 Cardiologics L.L.C. Method device for locating and sealing a blood vessel
EP0774922B1 (en) 1995-06-07 2002-08-14 Medtronic, Inc. Wound closure device
US6132438A (en) 1995-06-07 2000-10-17 Ep Technologies, Inc. Devices for installing stasis reducing means in body tissue
US5645565A (en) 1995-06-13 1997-07-08 Ethicon Endo-Surgery, Inc. Surgical plug
US5902311A (en) 1995-06-15 1999-05-11 Perclose, Inc. Low profile intraluminal suturing device and method
US5700273A (en) 1995-07-14 1997-12-23 C.R. Bard, Inc. Wound closure apparatus and method
US6096344A (en) 1995-07-28 2000-08-01 Advanced Polymer Systems, Inc. Bioerodible porous compositions
US5810846A (en) 1995-08-03 1998-09-22 United States Surgical Corporation Vascular hole closure
US6117144A (en) 1995-08-24 2000-09-12 Sutura, Inc. Suturing device and method for sealing an opening in a blood vessel or other biological structure
AU3410095A (en) 1995-08-24 1997-03-19 Inbae Yoon Suture tie device system and method for suturing anatomical tissue proximate an opening
US5683405A (en) 1995-08-25 1997-11-04 Research Medical Inc. Vascular occluder
US6071300A (en) 1995-09-15 2000-06-06 Sub-Q Inc. Apparatus and method for percutaneous sealing of blood vessel punctures
US5645566A (en) 1995-09-15 1997-07-08 Sub Q Inc. Apparatus and method for percutaneous sealing of blood vessel punctures
US5674231A (en) 1995-10-20 1997-10-07 United States Surgical Corporation Apparatus and method for vascular hole closure
US5700270A (en) 1995-10-20 1997-12-23 United States Surgical Corporation Surgical clip applier
ATE188862T1 (en) 1995-10-31 2000-02-15 Oticon As ANASTOMOTIC INSTRUMENT FOR USE IN A TERMINOLATERAL ANASTOMOSIS
US5827298A (en) 1995-11-17 1998-10-27 Innovasive Devices, Inc. Surgical fastening system and method for using the same
US6425901B1 (en) 1995-12-07 2002-07-30 Loma Linda University Medical Center Vascular wound closure system
US6004341A (en) 1996-12-05 1999-12-21 Loma Linda University Medical Center Vascular wound closure device
WO1997020505A1 (en) 1995-12-07 1997-06-12 Loma Linda University Medical Center Vascular wound closure device
US6287322B1 (en) 1995-12-07 2001-09-11 Loma Linda University Medical Center Tissue opening locator and everter and method
US5626614A (en) 1995-12-22 1997-05-06 Applied Medical Resources Corporation T-anchor suturing device and method for using same
EP1011889B1 (en) 1996-01-30 2002-10-30 Medtronic, Inc. Articles for and methods of making stents
USD383539S (en) 1996-02-01 1997-09-09 Ethicon Endo-Surgery, Inc. Handle for a surgical instrument
AU733341B2 (en) 1996-02-02 2001-05-10 Transvascular, Inc. A device, system and method for interstitial transvascular intervention
DE19604817C2 (en) 1996-02-09 2003-06-12 Pfm Prod Fuer Die Med Ag Device for closing defect openings in the human or animal body
US5810776A (en) 1996-02-13 1998-09-22 Imagyn Medical, Inc. Method and apparatus for performing laparoscopy
US5769870A (en) 1996-02-20 1998-06-23 Cardiothoracic Systems, Inc. Perfusion device for maintaining blood flow in a vessel while isolating an anastomosis
US5782917A (en) 1996-02-26 1998-07-21 Sunmed, Inc. Intramedullary bone plug
US5951575A (en) 1996-03-01 1999-09-14 Heartport, Inc. Apparatus and methods for rotationally deploying needles
US5810851A (en) 1996-03-05 1998-09-22 Yoon; Inbae Suture spring device
US5782844A (en) 1996-03-05 1998-07-21 Inbae Yoon Suture spring device applicator
US5853422A (en) 1996-03-22 1998-12-29 Scimed Life Systems, Inc. Apparatus and method for closing a septal defect
US5728132A (en) 1996-04-08 1998-03-17 Tricardia, L.L.C. Self-sealing vascular access device
US6149660A (en) 1996-04-22 2000-11-21 Vnus Medical Technologies, Inc. Method and apparatus for delivery of an appliance in a vessel
US6117125A (en) 1996-05-02 2000-09-12 Cook Incorporated Method for predetermining uniform flow rate of a fluid from a tubular body and device therefrom
EP0900051A1 (en) 1996-05-08 1999-03-10 Salviac Limited An occluder device
DK0906089T3 (en) 1996-05-13 2003-12-08 Novartis Consumer Health Sa The buccal delivery system
US5690674A (en) 1996-07-02 1997-11-25 Cordis Corporation Wound closure with plug
US5728133A (en) 1996-07-09 1998-03-17 Cardiologics, L.L.C. Anchoring device and method for sealing percutaneous punctures in vessels
US5957900A (en) 1996-07-10 1999-09-28 Asahi Kogaku Kogyo Kabushiki Kaisha Treatment accessory for endoscope
US5833698A (en) 1996-07-23 1998-11-10 United States Surgical Corporation Anastomosis instrument and method
US5820631A (en) 1996-08-01 1998-10-13 Nr Medical, Inc. Device and method for suturing tissue adjacent to a blood vessel
US5830217A (en) 1996-08-09 1998-11-03 Thomas J. Fogarty Soluble fixation device and method for stent delivery catheters
US5902310A (en) 1996-08-12 1999-05-11 Ethicon Endo-Surgery, Inc. Apparatus and method for marking tissue
WO1998007375A1 (en) 1996-08-22 1998-02-26 The Trustees Of Columbia University Endovascular flexible stapling device
CA2263421C (en) 1996-08-23 2012-04-17 William A. Cook Graft prosthesis, materials and methods
US5730758A (en) 1996-09-12 1998-03-24 Allgeyer; Dean O. Staple and staple applicator for use in skin fixation of catheters
US6488692B1 (en) 1996-09-16 2002-12-03 Origin Medsystems, Inc. Access and cannulation device and method for rapidly placing same and for rapidly closing same in minimally invasive surgery
US5830221A (en) 1996-09-20 1998-11-03 United States Surgical Corporation Coil fastener applier
US6152936A (en) 1996-09-23 2000-11-28 Esd Medical, Llc Surgical loop delivery device
US5948001A (en) 1996-10-03 1999-09-07 United States Surgical Corporation System for suture anchor placement
WO1998016161A1 (en) 1996-10-11 1998-04-23 Transvascular, Inc. Methods and apparatus for bypassing arterial obstructions and/or performing other transvascular procedures
US5755778A (en) 1996-10-16 1998-05-26 Nitinol Medical Technologies, Inc. Anastomosis device
WO1998018389A1 (en) 1996-10-25 1998-05-07 University Of Massachusetts Surgical vessel clips and methods for closing vessels
US5749826A (en) 1996-11-06 1998-05-12 Faulkner; James W. Urinary incontinence control device
JP2001504017A (en) 1996-11-15 2001-03-27 クック インコーポレーティッド. Separable sleeve, stent deployment device
US5947999A (en) 1996-12-03 1999-09-07 Groiso; Jorge A. Surgical clip and method
US5735873A (en) 1996-12-19 1998-04-07 Maclean; David S. Surgical tool handle
US6494848B1 (en) 1996-12-19 2002-12-17 St. Jude Medical Puerto Rico B.V. Measuring device for use with a hemostatic puncture closure device
US5782861A (en) 1996-12-23 1998-07-21 Sub Q Inc. Percutaneous hemostasis device
US5957938A (en) 1997-02-05 1999-09-28 United States Surgical Corporation Tissue everting needle
US5782860A (en) 1997-02-11 1998-07-21 Biointerventional Corporation Closure device for percutaneous occlusion of puncture sites and tracts in the human body and method
US6146385A (en) 1997-02-11 2000-11-14 Smith & Nephew, Inc. Repairing cartilage
US6056770A (en) 1997-02-11 2000-05-02 Biointerventional Corporation Expansile device for use in blood vessels and tracts in the body and method
US5951589A (en) 1997-02-11 1999-09-14 Biointerventional Corporation Expansile device for use in blood vessels and tracts in the body and tension application device for use therewith and method
US6056769A (en) 1997-02-11 2000-05-02 Biointerventional Corporation Expansile device for use in blood vessels and tracts in the body and tension application device for use therewith and method
US6045570A (en) 1997-02-11 2000-04-04 Biointerventional Corporation Biological sealant mixture and system for use in percutaneous occlusion of puncture sites and tracts in the human body and method
EP0858776A3 (en) 1997-02-14 2000-01-12 Tricardia, L.L.C. Hemostatic agent delivery device having built-in pressure sensor
EP0934092A4 (en) 1997-03-06 2008-03-26 Boston Scient Scimed Inc Distal protection device and method
US5752966A (en) 1997-03-07 1998-05-19 Chang; David W. Exovascular anastomotic device
US5908149A (en) 1997-03-12 1999-06-01 Ethicon Endo-Surgery, Inc. Skin stapler with multi-directional release mechanism
DE29723736U1 (en) 1997-03-18 1999-02-18 Wurster Helmut Dipl Ing Surgical clamp for connecting tissue parts
DE19711288B4 (en) 1997-03-18 2004-11-04 Helmut Dipl.-Ing. Wurster Applicator to hold and close a surgical clip
US5984948A (en) 1997-04-14 1999-11-16 Hasson; Harrith M. Device for closing an opening in tissue and method of closing a tissue opening using the device
US5897487A (en) 1997-04-15 1999-04-27 Asahi Kogaku Kogyo Kabushiki Kaisha Front end hood for endoscope
WO1998047447A1 (en) 1997-04-23 1998-10-29 Dubrul William R Bifurcated stent and distal protection system
US5957936A (en) 1997-05-01 1999-09-28 Inbae Yoon Instrument assemblies for performing anatomical tissue ligation
US6409739B1 (en) 1997-05-19 2002-06-25 Cardio Medical Solutions, Inc. Device and method for assisting end-to side anastomosis
US6896687B2 (en) 1997-05-19 2005-05-24 Pepi Dakov Connectors for hollow anatomical structures and methods of use
US6443158B1 (en) 1997-06-19 2002-09-03 Scimed Life Systems, Inc. Percutaneous coronary artery bypass through a venous vessel
US6001110A (en) 1997-06-20 1999-12-14 Boston Scientific Corporation Hemostatic clips
US5957940A (en) 1997-06-30 1999-09-28 Eva Corporation Fasteners for use in the surgical repair of aneurysms
US5928260A (en) 1997-07-10 1999-07-27 Scimed Life Systems, Inc. Removable occlusion system for aneurysm neck
US5972034A (en) 1997-07-29 1999-10-26 Joint Enterprises, L.C. A Limited Corporation Self-venting intramedullary cement restrictor
EP0895753A1 (en) 1997-07-31 1999-02-10 Academisch Ziekenhuis Utrecht Temporary vascular seal for anastomosis
AU8772198A (en) 1997-08-05 1999-03-08 Target Therapeutics, Inc. Detachable aneurysm neck bridge
US6063114A (en) 1997-09-04 2000-05-16 Kensey Nash Corporation Connector system for vessels, ducts, lumens or hollow organs and methods of use
US5954732A (en) 1997-09-10 1999-09-21 Hart; Charles C. Suturing apparatus and method
US6059800A (en) 1997-09-10 2000-05-09 Applied Medical Resources Corporation Suturing apparatus and method
FR2768324B1 (en) 1997-09-12 1999-12-10 Jacques Seguin SURGICAL INSTRUMENT FOR PERCUTANEOUSLY FIXING TWO AREAS OF SOFT TISSUE, NORMALLY MUTUALLY REMOTE, TO ONE ANOTHER
US5928251A (en) 1997-09-18 1999-07-27 United States Surgical Corporation Occlusion clamp and occlusion clamp applicator
US5964782A (en) 1997-09-18 1999-10-12 Scimed Life Systems, Inc. Closure device and method
US6030364A (en) 1997-10-03 2000-02-29 Boston Scientific Corporation Apparatus and method for percutaneous placement of gastro-intestinal tubes
US5984949A (en) 1997-10-06 1999-11-16 Levin; John M. Tissue hooks and tools for applying same
TW527195B (en) 1997-10-09 2003-04-11 Ssp Co Ltd Fast-soluble solid pharmaceutical combinations
US5984934A (en) 1997-10-10 1999-11-16 Applied Medical Resources Corporation Low-profile surgical clip
US6117148A (en) 1997-10-17 2000-09-12 Ravo; Biagio Intraluminal anastomotic device
NL1007349C2 (en) 1997-10-24 1999-04-27 Suyker Wilhelmus Joseph Leonardus System for the mechanical production of anastomoses between hollow structures; as well as device and applicator for use therewith.
US5951518A (en) 1997-10-31 1999-09-14 Teleflex, Incorporated Introducing device with flared sheath end
US5906631A (en) 1997-12-05 1999-05-25 Surface Genesis, Inc. Method and device for sealing vascular puncture wounds
US6254642B1 (en) 1997-12-09 2001-07-03 Thomas V. Taylor Perorally insertable gastroesophageal anti-reflux valve prosthesis and tool for implantation thereof
US6036720A (en) 1997-12-15 2000-03-14 Target Therapeutics, Inc. Sheet metal aneurysm neck bridge
US5976174A (en) 1997-12-15 1999-11-02 Ruiz; Carlos E. Medical hole closure device and methods of use
US5976161A (en) 1998-01-07 1999-11-02 University Of New Mexico Tissue everting apparatus and method
US6033427A (en) 1998-01-07 2000-03-07 Lee; Benjamin I. Method and device for percutaneous sealing of internal puncture sites
US6193734B1 (en) 1998-01-23 2001-02-27 Heartport, Inc. System for performing vascular anastomoses
ATE320229T1 (en) 1998-01-30 2006-04-15 St Jude Medical Atg Inc MEDICAL TRANSPLANT CONNECTOR OR PLUG AND METHOD FOR PRODUCING THE SAME
US6036703A (en) 1998-02-06 2000-03-14 Ethicon Endo-Surgery Inc. Method and apparatus for establishing anastomotic passageways
CH693017A5 (en) 1998-02-10 2003-01-31 Jump Jeffrey B surgical device occlusion defects.
US6280460B1 (en) 1998-02-13 2001-08-28 Heartport, Inc. Devices and methods for performing vascular anastomosis
US5951576A (en) 1998-03-02 1999-09-14 Wakabayashi; Akio End-to-side vascular anastomosing stapling device
NO981277D0 (en) 1998-03-20 1998-03-20 Erik Fosse Method and apparatus for suture-free anastomosis
WO1999049910A2 (en) 1998-03-31 1999-10-07 Transvascular, Inc. Transvascular catheters having imaging transducers
IE980241A1 (en) 1998-04-02 1999-10-20 Salviac Ltd Delivery catheter with split sheath
US6706051B2 (en) 1998-04-08 2004-03-16 Bhk Holding, Ltd. Hemostatic system for body cavities
US6241740B1 (en) 1998-04-09 2001-06-05 Origin Medsystems, Inc. System and method of use for ligating and cutting tissue
US6149667A (en) 1998-05-11 2000-11-21 Surgical Connections, Inc. Devices and methods for treating E.G. urinary stress incontinence
WO1999060941A1 (en) 1998-05-26 1999-12-02 Circulation, Inc. Apparatus for providing coronary retroperfusion and methods of use
US6113611A (en) 1998-05-28 2000-09-05 Advanced Vascular Technologies, Llc Surgical fastener and delivery system
JP2002516696A (en) 1998-05-29 2002-06-11 バイ−パス・インク. Methods and devices for vascular surgery
AU4056499A (en) 1998-05-29 1999-12-20 By-Pass, Ltd. Vascular port device
WO2000056227A1 (en) 1999-03-19 2000-09-28 By-Pass, Inc. Advanced closure device
US7063711B1 (en) 1998-05-29 2006-06-20 By-Pass, Inc. Vascular surgery
US7060084B1 (en) 1998-05-29 2006-06-13 By-Pass, Inc. Vascular closure device
WO2000056228A1 (en) 1999-03-19 2000-09-28 By-Pass, Inc. Low profile anastomosis connector
US20040087985A1 (en) 1999-03-19 2004-05-06 Amir Loshakove Graft and connector delivery
US6726704B1 (en) 1998-05-29 2004-04-27 By-Pass, Inc. Advanced closure device
US20050283188A1 (en) 1998-05-29 2005-12-22 By-Pass, Inc. Vascular closure device
US5919207A (en) 1998-06-02 1999-07-06 Taheri; Syde A. Percutaneous arterial closure with staples
US6613059B2 (en) 1999-03-01 2003-09-02 Coalescent Surgical, Inc. Tissue connector apparatus and methods
US6599311B1 (en) 1998-06-05 2003-07-29 Broncus Technologies, Inc. Method and assembly for lung volume reduction
US5910155A (en) 1998-06-05 1999-06-08 United States Surgical Corporation Vascular wound closure system
US5941890A (en) 1998-06-26 1999-08-24 Ethicon Endo-Surgery, Inc. Implantable surgical marker
US6228098B1 (en) 1998-07-10 2001-05-08 General Surgical Innovations, Inc. Apparatus and method for surgical fastening
US6048358A (en) 1998-07-13 2000-04-11 Barak; Shlomo Method and apparatus for hemostasis following arterial catheterization
JP2003521270A (en) 1998-08-04 2003-07-15 フュージョン メディカル テクノロジーズ, インコーポレイテッド Percutaneous tissue tract occlusion assemblies and methods
DE19859952A1 (en) 1998-08-11 2000-02-17 S & T Marketing Ag Neuhausen Micro-surgical clamps are produced from a flat strip of metal remaining attached within a recess in the strip
US6206913B1 (en) 1998-08-12 2001-03-27 Vascular Innovations, Inc. Method and system for attaching a graft to a blood vessel
US6198974B1 (en) 1998-08-14 2001-03-06 Cordis Webster, Inc. Bi-directional steerable catheter
US6703047B2 (en) 2001-02-02 2004-03-09 Incept Llc Dehydrated hydrogel precursor-based, tissue adherent compositions and methods of use
US7335220B2 (en) 2004-11-05 2008-02-26 Access Closure, Inc. Apparatus and methods for sealing a vascular puncture
DE19839188C2 (en) 1998-08-28 2003-08-21 Storz Endoskop Gmbh Schaffhaus endoscope
US6200329B1 (en) 1998-08-31 2001-03-13 Smith & Nephew, Inc. Suture collet
US6093194A (en) 1998-09-14 2000-07-25 Endocare, Inc. Insertion device for stents and methods for use
US6296657B1 (en) 1998-10-07 2001-10-02 Gregory G. Brucker Vascular sealing device and method
US6220248B1 (en) 1998-10-21 2001-04-24 Ethicon Endo-Surgery, Inc. Method for implanting a biopsy marker
DE69925854T2 (en) 1998-10-23 2006-05-11 Sherwood Services Ag ENDOSCOPIC BIPOLAR ELECTRO-SURGICAL TONGUE
US6183496B1 (en) 1998-11-02 2001-02-06 Datascope Investment Corp. Collapsible hemostatic plug
US6152144A (en) 1998-11-06 2000-11-28 Appriva Medical, Inc. Method and device for left atrial appendage occlusion
US6113612A (en) 1998-11-06 2000-09-05 St. Jude Medical Cardiovascular Group, Inc. Medical anastomosis apparatus
US6152937A (en) 1998-11-06 2000-11-28 St. Jude Medical Cardiovascular Group, Inc. Medical graft connector and methods of making and installing same
US6102271A (en) 1998-11-23 2000-08-15 Ethicon Endo-Surgery, Inc. Circular stapler for hemorrhoidal surgery
US6200330B1 (en) 1998-11-23 2001-03-13 Theodore V. Benderev Systems for securing sutures, grafts and soft tissue to bone and periosteum
US6080183A (en) 1998-11-24 2000-06-27 Embol-X, Inc. Sutureless vessel plug and methods of use
US6210407B1 (en) 1998-12-03 2001-04-03 Cordis Webster, Inc. Bi-directional electrode catheter
US6126675A (en) 1999-01-11 2000-10-03 Ethicon, Inc. Bioabsorbable device and method for sealing vascular punctures
US6074395A (en) 1999-02-02 2000-06-13 Linvatec Corporation Cannulated tissue anchor insertion system
US6217554B1 (en) 1999-02-12 2001-04-17 Pharmaspec Corporation Methods and apparatus for delivering substances into extravascular tissue
US6120524A (en) 1999-02-16 2000-09-19 Taheri; Syde A. Device for closing an arterial puncture and method
US7235087B2 (en) 1999-03-04 2007-06-26 Abbott Park Articulating suturing device and method
US7001400B1 (en) 1999-03-04 2006-02-21 Abbott Laboratories Articulating suturing device and method
US6964668B2 (en) 1999-03-04 2005-11-15 Abbott Laboratories Articulating suturing device and method
US6136010A (en) 1999-03-04 2000-10-24 Perclose, Inc. Articulating suturing device and method
US8137364B2 (en) 2003-09-11 2012-03-20 Abbott Laboratories Articulating suturing device and method
US7842048B2 (en) 2006-08-18 2010-11-30 Abbott Laboratories Articulating suture device and method
US20040092964A1 (en) 1999-03-04 2004-05-13 Modesitt D. Bruce Articulating suturing device and method
EP1161185A2 (en) 1999-03-09 2001-12-12 St. Jude Medical Cardiovascular Group, Inc. Medical grafting methods and apparatus
AU3746200A (en) 1999-03-15 2000-10-04 Bolder Technologies Corporation Tin-clad substrates for use as current collectors, batteries comprised thereof and methods for preparing same
KR20020067616A (en) 1999-03-19 2002-08-23 바이-패스, 인크. Vascular surgery
US7563267B2 (en) 1999-04-09 2009-07-21 Evalve, Inc. Fixation device and methods for engaging tissue
US20040044350A1 (en) 1999-04-09 2004-03-04 Evalve, Inc. Steerable access sheath and methods of use
US6752813B2 (en) 1999-04-09 2004-06-22 Evalve, Inc. Methods and devices for capturing and fixing leaflets in valve repair
US6623494B1 (en) 1999-04-16 2003-09-23 Integrated Vascular Interventional Technologies, L.C. (Ivit, Lc) Methods and systems for intraluminally directed vascular anastomosis
US6569173B1 (en) 1999-12-14 2003-05-27 Integrated Vascular Interventional Technologies, L.C. Compression plate anastomosis apparatus
US6626921B2 (en) 1999-04-16 2003-09-30 Integrated Vascular Interventional Technologies, L.C. Externally positioned anvil apparatus for cutting anastomosis
US6632197B2 (en) 1999-04-16 2003-10-14 Thomas R. Lyon Clear view cannula
JP2000300571A (en) 1999-04-19 2000-10-31 Nissho Corp Closure plug for transcatheter operation
IT1312196B1 (en) 1999-04-21 2002-04-09 Implant Italia S R L SEMI-RIGID COMPRESSION CLAMP FOR STERNOTOMY, AND CLAMP FOR ITS APPLICATION.
US6287335B1 (en) 1999-04-26 2001-09-11 William J. Drasler Intravascular folded tubular endoprosthesis
US6302870B1 (en) 1999-04-29 2001-10-16 Precision Vascular Systems, Inc. Apparatus for injecting fluids into the walls of blood vessels, body cavities, and the like
US6261258B1 (en) 1999-05-03 2001-07-17 Marius Saines Hemostatic device for angioplasty
US6712836B1 (en) 1999-05-13 2004-03-30 St. Jude Medical Atg, Inc. Apparatus and methods for closing septal defects and occluding blood flow
WO2000069364A2 (en) 1999-05-18 2000-11-23 Vascular Innovations, Inc. Implantable medical device such as an anastomosis device
US6699256B1 (en) 1999-06-04 2004-03-02 St. Jude Medical Atg, Inc. Medical grafting apparatus and methods
US6165204A (en) 1999-06-11 2000-12-26 Scion International, Inc. Shaped suture clip, appliance and method therefor
EP1196092A1 (en) 1999-06-18 2002-04-17 Radi Medical Systems Ab A tool, a sealing device, a system and a method for closing a wound
US7416554B2 (en) * 2002-12-11 2008-08-26 Usgi Medical Inc Apparatus and methods for forming and securing gastrointestinal tissue folds
US6206895B1 (en) 1999-07-13 2001-03-27 Scion Cardio-Vascular, Inc. Suture with toggle and delivery system
US6398796B2 (en) 1999-07-13 2002-06-04 Scion Cardio-Vascular, Inc. Suture with toggle and delivery system
US6267773B1 (en) 1999-07-15 2001-07-31 Donald L. Gadberry Low profile surgical clip
JP3917332B2 (en) 1999-08-04 2007-05-23 ペンタックス株式会社 Endoscope operation wire connecting part
US6110184A (en) 1999-08-04 2000-08-29 Weadock; Kevin S. Introducer with vascular sealing mechanism
AU5812299A (en) 1999-09-07 2001-04-10 Microvena Corporation Retrievable septal defect closure device
CA2381818C (en) 1999-09-13 2009-08-04 Rex Medical, L.P. Vascular closure
US7267679B2 (en) 1999-09-13 2007-09-11 Rex Medical, L.P Vascular hole closure device
US6358258B1 (en) 1999-09-14 2002-03-19 Abbott Laboratories Device and method for performing end-to-side anastomosis
US6421899B1 (en) 1999-09-15 2002-07-23 Emhart Llc Extraction and adjustment tool for tangless inserts
US6231561B1 (en) 1999-09-20 2001-05-15 Appriva Medical, Inc. Method and apparatus for closing a body lumen
US6984219B2 (en) 1999-09-23 2006-01-10 Mark Ashby Depth and puncture control for blood vessel hemostasis system
CA2384817C (en) 1999-09-23 2009-10-20 Sub-Q, Inc. Device and method for determining a depth of an incision
US6319258B1 (en) 1999-09-29 2001-11-20 Ethicon, Inc. Absorbable rivet/pin applier for use in surgical procedures
US6312447B1 (en) 1999-10-13 2001-11-06 The General Hospital Corporation Devices and methods for percutaneous mitral valve repair
US6626930B1 (en) 1999-10-21 2003-09-30 Edwards Lifesciences Corporation Minimally invasive mitral valve repair method and apparatus
US6409753B1 (en) 1999-10-26 2002-06-25 Scimed Life Systems, Inc. Flexible stent
US6689150B1 (en) 1999-10-27 2004-02-10 Atritech, Inc. Filter apparatus for ostium of left atrial appendage
US6383208B1 (en) 1999-11-05 2002-05-07 Onux Medical, Inc. Apparatus and method for approximating and closing the walls of a hole or puncture in a physiological shell structure
US6273903B1 (en) 1999-11-08 2001-08-14 Peter J. Wilk Endoscopic stapling device and related staple
US6428548B1 (en) 1999-11-18 2002-08-06 Russell F. Durgin Apparatus and method for compressing body tissue
US6689062B1 (en) 1999-11-23 2004-02-10 Microaccess Medical Systems, Inc. Method and apparatus for transesophageal cardiovascular procedures
US6602263B1 (en) 1999-11-30 2003-08-05 St. Jude Medical Atg, Inc. Medical grafting methods and apparatus
DE59901090D1 (en) 1999-12-23 2002-05-02 Storz Karl Gmbh & Co Kg Decentralized drive screw
US6790218B2 (en) 1999-12-23 2004-09-14 Swaminathan Jayaraman Occlusive coil manufacture and delivery
GB9930654D0 (en) 1999-12-23 2000-02-16 Halpin Richard M B Device for controlling extra-vascular haemorrhage
US20050187564A1 (en) 1999-12-23 2005-08-25 Swaminathan Jayaraman Occlusive coil manufacturing and delivery
US6197042B1 (en) 2000-01-05 2001-03-06 Medical Technology Group, Inc. Vascular sheath with puncture site closure apparatus and methods of use
US9579091B2 (en) 2000-01-05 2017-02-28 Integrated Vascular Systems, Inc. Closure system and methods of use
US7842068B2 (en) 2000-12-07 2010-11-30 Integrated Vascular Systems, Inc. Apparatus and methods for providing tactile feedback while delivering a closure device
US6780197B2 (en) 2000-01-05 2004-08-24 Integrated Vascular Systems, Inc. Apparatus and methods for delivering a vascular closure device to a body lumen
US6942674B2 (en) 2000-01-05 2005-09-13 Integrated Vascular Systems, Inc. Apparatus and methods for delivering a closure device
US6461364B1 (en) 2000-01-05 2002-10-08 Integrated Vascular Systems, Inc. Vascular sheath with bioabsorbable puncture site closure apparatus and methods of use
US8758400B2 (en) 2000-01-05 2014-06-24 Integrated Vascular Systems, Inc. Closure system and methods of use
WO2001049186A2 (en) 2000-01-05 2001-07-12 Integrated Vascular Systems, Inc. Apparatus for closing tissue punctures
US6391048B1 (en) 2000-01-05 2002-05-21 Integrated Vascular Systems, Inc. Integrated vascular device with puncture site closure component and sealant and methods of use
JP4347486B2 (en) 2000-01-24 2009-10-21 辰雄 金重 Indwelling catheter
US6547806B1 (en) 2000-02-04 2003-04-15 Ni Ding Vascular sealing device and method of use
GB2359024A (en) 2000-02-09 2001-08-15 Anson Medical Ltd Fixator for arteries
JP3844661B2 (en) 2000-04-19 2006-11-15 ラディ・メディカル・システムズ・アクチェボラーグ Intra-arterial embolus
US6942691B1 (en) 2000-04-27 2005-09-13 Timothy A. M. Chuter Modular bifurcated graft for endovascular aneurysm repair
US7361185B2 (en) 2001-05-09 2008-04-22 Canica Design, Inc. Clinical and surgical system and method for moving and stretching plastic tissue
US6305891B1 (en) 2000-05-15 2001-10-23 Mark S. Burlingame Fastening device and a spacer, and a method of using the same
WO2001091628A2 (en) 2000-05-31 2001-12-06 Origin Medsystems, Inc. Method and apparatus for performing end-to-end and end-to-side anastomosis with eversion of tissue edges
US7534242B2 (en) 2003-02-25 2009-05-19 Artemis Medical, Inc. Tissue separating catheter assembly and method
IL136702A (en) 2000-06-12 2005-11-20 Niti Alloys Tech Ltd Surgical clip
US6689147B1 (en) 2000-06-13 2004-02-10 J. Kenneth Koster, Jr. Anastomosis punch device and method
AU2001269825A1 (en) 2000-06-14 2001-12-24 Sterilis, Inc. Suturing method and apparatus
US6702826B2 (en) 2000-06-23 2004-03-09 Viacor, Inc. Automated annular plication for mitral valve repair
WO2002005865A2 (en) 2000-07-14 2002-01-24 Sub-Q, Inc. Sheath-mounted arterial plug delivery device
US6443963B1 (en) 2000-07-26 2002-09-03 Orthopaedic Biosystems, Ltd. Apparatus and method for repairing or reattaching soft tissue
AU2001260010B2 (en) 2000-07-27 2004-08-26 Synthes Gmbh Cranial flap clamp and instrument for use therewith
US6428472B1 (en) 2000-08-08 2002-08-06 Kent Haas Surgical retractor having a malleable support
EP1309280A2 (en) 2000-08-11 2003-05-14 SDGI Holdings, Inc. Surgical instrumentation and method for treatment of the spine
US6572629B2 (en) 2000-08-17 2003-06-03 Johns Hopkins University Gastric reduction endoscopy
US7074232B2 (en) 2000-09-01 2006-07-11 Medtronic Angiolink, Inc. Advanced wound site management systems and methods
US6755842B2 (en) 2000-09-01 2004-06-29 Angiolink Corporation Advanced wound site management systems and methods
US20040093024A1 (en) 2000-09-01 2004-05-13 James Lousararian Advanced wound site management systems and methods
US6767356B2 (en) 2000-09-01 2004-07-27 Angiolink Corporation Advanced wound site management systems and methods
US6533762B2 (en) 2000-09-01 2003-03-18 Angiolink Corporation Advanced wound site management systems and methods
US6517555B1 (en) 2000-09-05 2003-02-11 Clear Sight, Inc. Method for treating presbyopia
AU2001288006A1 (en) 2000-09-08 2002-03-22 Thomas Anthony Device for locating a puncture hole in a liquid-carrying vessel
ZA200100527B (en) 2000-09-08 2001-01-19 James E Coleman Surgical stapler.
US6633234B2 (en) 2000-10-20 2003-10-14 Ethicon Endo-Surgery, Inc. Method for detecting blade breakage using rate and/or impedance information
US6663633B1 (en) 2000-10-25 2003-12-16 Pierson, Iii Raymond H. Helical orthopedic fixation and reduction device, insertion system, and associated methods
US6645225B1 (en) 2000-11-01 2003-11-11 Alvan W. Atkinson Method and apparatus for plugging a patent foramen ovale formed in the heart
WO2002064012A2 (en) 2000-11-07 2002-08-22 Artemis Medical, Inc. Target tissue localization assembly and method
US6551319B2 (en) 2000-11-08 2003-04-22 The Cleveland Clinic Foundation Apparatus for implantation into bone
US6966917B1 (en) 2000-11-09 2005-11-22 Innovation Interventional Technologies B.V. Deformable connector for mechanically connecting hollow structures
US6884235B2 (en) 2000-12-06 2005-04-26 Rex Medical, L.P. Introducer sheath with retainer and radiopaque insert
US6695867B2 (en) 2002-02-21 2004-02-24 Integrated Vascular Systems, Inc. Plunger apparatus and methods for delivering a closure device
US7211101B2 (en) 2000-12-07 2007-05-01 Abbott Vascular Devices Methods for manufacturing a clip and clip
US6719777B2 (en) 2000-12-07 2004-04-13 Integrated Vascular Systems, Inc. Closure device and methods for making and using them
US8690910B2 (en) 2000-12-07 2014-04-08 Integrated Vascular Systems, Inc. Closure device and methods for making and using them
US7806904B2 (en) 2000-12-07 2010-10-05 Integrated Vascular Systems, Inc. Closure device
US8083768B2 (en) 2000-12-14 2011-12-27 Ensure Medical, Inc. Vascular plug having composite construction
US6890343B2 (en) 2000-12-14 2005-05-10 Ensure Medical, Inc. Plug with detachable guidewire element and methods for use
US6969397B2 (en) 2000-12-14 2005-11-29 Ensure Medical, Inc. Guide wire element for positioning vascular closure devices and methods for use
US6623509B2 (en) 2000-12-14 2003-09-23 Core Medical, Inc. Apparatus and methods for sealing vascular punctures
US6896692B2 (en) 2000-12-14 2005-05-24 Ensure Medical, Inc. Plug with collet and apparatus and method for delivering such plugs
US6855161B2 (en) 2000-12-27 2005-02-15 Advanced Cardiovascular Systems, Inc. Radiopaque nitinol alloys for medical devices
US20040059376A1 (en) 2001-01-31 2004-03-25 Helmut Breuniger Device for the introduction and fashioning of skin clips
US6569185B2 (en) 2001-02-15 2003-05-27 Scimed Life Systems Inc Continuous infusion technique for arterial sealing
US6743195B2 (en) 2001-03-14 2004-06-01 Cardiodex Balloon method and apparatus for vascular closure following arterial catheterization
USD457958S1 (en) 2001-04-06 2002-05-28 Sherwood Services Ag Vessel sealer and divider
US7025776B1 (en) 2001-04-24 2006-04-11 Advanced Catheter Engineering, Inc. Arteriotomy closure devices and techniques
US20020188170A1 (en) 2001-04-27 2002-12-12 Santamore William P. Prevention of myocardial infarction induced ventricular expansion and remodeling
US6535764B2 (en) 2001-05-01 2003-03-18 Intrapace, Inc. Gastric treatment and diagnosis device and method
US20020173803A1 (en) 2001-05-01 2002-11-21 Stephen Ainsworth Self-closing surgical clip for tissue
JP4267867B2 (en) 2001-05-03 2009-05-27 ラディ・メディカル・システムズ・アクチェボラーグ Wound occlusion element guide device
ATE272359T1 (en) 2001-05-09 2004-08-15 Radi Medical Systems DEVICE FOR SEALING AN ARTERIAL PERFORATION
US7087088B2 (en) 2001-05-24 2006-08-08 Torax Medical, Inc. Methods and apparatus for regulating the flow of matter through body tubing
US6537300B2 (en) 2001-05-30 2003-03-25 Scimed Life Systems, Inc. Implantable obstruction device for septal defects
US7083629B2 (en) 2001-05-30 2006-08-01 Satiety, Inc. Overtube apparatus for insertion into a body
US7033379B2 (en) 2001-06-08 2006-04-25 Incisive Surgical, Inc. Suture lock having non-through bore capture zone
CA2448900C (en) 2001-06-08 2011-05-17 Morris Innovative Research, Inc. Method and apparatus for sealing access
US20020198589A1 (en) 2001-06-22 2002-12-26 Leong Veronica Jade Tessellated stent and method of manufacture
US6626920B2 (en) 2001-07-05 2003-09-30 Converge Medical, Inc. Distal anastomosis system
US7288105B2 (en) 2001-08-01 2007-10-30 Ev3 Endovascular, Inc. Tissue opening occluder
WO2003013374A1 (en) 2001-08-06 2003-02-20 Penn State Research Foundation Multifunctional tool and method for minimally invasive surgery
IES20010748A2 (en) 2001-08-09 2003-02-19 Christy Cummins Surgical Stapling Device and Method
US6645205B2 (en) 2001-08-15 2003-11-11 Core Medical, Inc. Apparatus and methods for reducing lung volume
US6929634B2 (en) 2001-08-22 2005-08-16 Gore Enterprise Holdings, Inc. Apparatus and methods for treating stroke and controlling cerebral flow characteristics
US6634537B2 (en) 2001-08-23 2003-10-21 Tung-I Chen Detachable insulation wire-pressing element of a stapling device
US7338506B2 (en) 2001-09-05 2008-03-04 Caro Nicholas C Scleral clip and procedures for using same
US20090054912A1 (en) 2001-09-06 2009-02-26 Heanue Taylor A Systems and Methods for Treating Septal Defects
US20070129755A1 (en) 2005-12-05 2007-06-07 Ovalis, Inc. Clip-based systems and methods for treating septal defects
US6776784B2 (en) 2001-09-06 2004-08-17 Core Medical, Inc. Clip apparatus for closing septal defects and methods of use
US6596013B2 (en) 2001-09-20 2003-07-22 Scimed Life Systems, Inc. Method and apparatus for treating septal defects
US6685620B2 (en) 2001-09-25 2004-02-03 The Foundry Inc. Ventricular infarct assist device and methods for using it
US7144363B2 (en) 2001-10-16 2006-12-05 Extensia Medical, Inc. Systems for heart treatment
US6620165B2 (en) 2001-11-26 2003-09-16 Bioplate, Inc. Bone alignment and fixation plate and installation method
US20080249504A1 (en) 2007-04-06 2008-10-09 Lattouf Omar M Instrument port
US20030139819A1 (en) 2002-01-18 2003-07-24 Beer Nicholas De Method and apparatus for closing septal defects
WO2003096895A1 (en) 2002-01-18 2003-11-27 Std Manufacturing, Inc. Ablation technology for catheter based delivery systems
US6743241B2 (en) 2002-03-01 2004-06-01 Intellimed Surgical Solutions Llc Laparoscopic port site fascial closure device
US20040093027A1 (en) 2002-03-04 2004-05-13 Walter Fabisiak Barbed tissue connector for sealing vascular puncture wounds
AU2003231752A1 (en) 2002-04-22 2003-11-03 Tyco Healthcare Group, Lp Tack and tack applier
WO2003090628A1 (en) 2002-04-25 2003-11-06 Terumo Kabushiki Kaisha Organism tissue suturing apparatus
US7077850B2 (en) 2002-05-01 2006-07-18 Scimed Life Systems, Inc. Tissue fastening devices and related insertion tools and methods
JP4350646B2 (en) 2002-05-08 2009-10-21 ラディ・メディカル・システムズ・アクチェボラーグ Decomposable medical sealing device
AU2003234309A1 (en) 2002-05-10 2003-11-11 Core Medical, Inc. Plug with collet and detachable guidewire element for positioning vascular closure devices and methods for use
JP4508866B2 (en) 2002-06-04 2010-07-21 アボット ヴァスキュラー デヴァイシス Vascular closure clip and delivery device
WO2003103476A2 (en) 2002-06-05 2003-12-18 Nmt Medical, Inc. Patent foramen ovale (pfo) closure device with radial and circumferential support
US20040002763A1 (en) * 2002-06-27 2004-01-01 Raymedica, Inc. Spinal disc anulus occlusion device and method of use
IES20030490A2 (en) 2002-07-03 2004-01-14 Paul Hooi Surgical stapling device
EP1526810B1 (en) 2002-07-31 2009-04-15 Abbott Laboratories Vascular Enterprises Limited Apparatus for sealing surgical punctures
JP2005534388A (en) 2002-08-01 2005-11-17 アボット ラボラトリーズ バスキュラー エンタープライゼズ リミテッド Self trauma seal device
MXPA05001845A (en) 2002-08-15 2005-11-17 Gmp Cardiac Care Inc Stent-graft with rails.
ES2298556T3 (en) 2002-09-23 2008-05-16 Nmt Medical, Inc. SEPTAL PUNCTURE DEVICE.
US20040068273A1 (en) 2002-10-02 2004-04-08 Ibionics Corporation Automatic laparoscopic incision closing apparatus
US7087064B1 (en) 2002-10-15 2006-08-08 Advanced Cardiovascular Systems, Inc. Apparatuses and methods for heart valve repair
US7493154B2 (en) 2002-10-23 2009-02-17 Medtronic, Inc. Methods and apparatus for locating body vessels and occlusions in body vessels
US7160309B2 (en) 2002-12-31 2007-01-09 Laveille Kao Voss Systems for anchoring a medical device in a body lumen
GB0300786D0 (en) 2003-01-14 2003-02-12 Barker Stephen G E Laparoscopic port hernia device
US7008442B2 (en) 2003-01-20 2006-03-07 Medtronic Vascular, Inc. Vascular sealant delivery device and sheath introducer and method
US7115135B2 (en) 2003-01-22 2006-10-03 Cardia, Inc. Occlusion device having five or more arms
US8758398B2 (en) 2006-09-08 2014-06-24 Integrated Vascular Systems, Inc. Apparatus and method for delivering a closure element
US7857828B2 (en) 2003-01-30 2010-12-28 Integrated Vascular Systems, Inc. Clip applier and methods of use
US8821534B2 (en) 2010-12-06 2014-09-02 Integrated Vascular Systems, Inc. Clip applier having improved hemostasis and methods of use
US8202293B2 (en) 2003-01-30 2012-06-19 Integrated Vascular Systems, Inc. Clip applier and methods of use
US8398656B2 (en) 2003-01-30 2013-03-19 Integrated Vascular Systems, Inc. Clip applier and methods of use
US8905937B2 (en) 2009-02-26 2014-12-09 Integrated Vascular Systems, Inc. Methods and apparatus for locating a surface of a body lumen
JP4094445B2 (en) 2003-01-31 2008-06-04 オリンパス株式会社 Endoscopic mucosal resection tool
EP1444993B2 (en) 2003-02-10 2013-06-26 W.C. Heraeus GmbH Improved metal alloy for medical devices and implants
US20070276488A1 (en) 2003-02-10 2007-11-29 Jurgen Wachter Medical implant or device
DE10310995B3 (en) 2003-03-06 2004-09-16 Aesculap Ag & Co. Kg Closure device for a puncture channel and applicator device
AU2004220635A1 (en) 2003-03-06 2004-09-23 Applied Medical Resources Corporation Spring clip and method for assembling same
US7850654B2 (en) 2003-04-24 2010-12-14 St. Jude Medical Puerto Rico B.V. Device and method for positioning a closure device
US20040225301A1 (en) 2003-05-05 2004-11-11 St. Jude Medical, Daig Division, Inc. Loop closure apparatus and method
US7112216B2 (en) 2003-05-28 2006-09-26 Boston Scientific Scimed, Inc. Stent with tapered flexibility
US6942641B2 (en) 2003-05-30 2005-09-13 J. Michael Seddon Catheter
US9289195B2 (en) 2003-06-04 2016-03-22 Access Closure, Inc. Auto-retraction apparatus and methods for sealing a vascular puncture
US20040249412A1 (en) 2003-06-04 2004-12-09 Snow Brent W. Apparatus and methods for puncture site closure
US20070093869A1 (en) 2003-06-20 2007-04-26 Medtronic Vascular, Inc. Device, system, and method for contracting tissue in a mammalian body
US8480706B2 (en) 2003-07-14 2013-07-09 W.L. Gore & Associates, Inc. Tubular patent foramen ovale (PFO) closure device with catch system
ES2428967T3 (en) 2003-07-14 2013-11-12 W.L. Gore & Associates, Inc. Oval foramen tubular permeable closure device (FOP) with retention system
DE10335648A1 (en) 2003-07-30 2005-03-03 Eberhard-Karls-Universität Tübingen Closing plug for an opening in a wall of a vessel or hollow organ
WO2005027753A1 (en) 2003-09-19 2005-03-31 St. Jude Medical, Inc. Apparatus and methods for tissue gathering and securing
US7462188B2 (en) 2003-09-26 2008-12-09 Abbott Laboratories Device and method for suturing intracardiac defects
US20050075654A1 (en) 2003-10-06 2005-04-07 Brian Kelleher Methods and devices for soft tissue securement
US7931670B2 (en) 2003-10-15 2011-04-26 St. Jude Medical Puerto Rico Llc Tissue puncture closure device with automatic tamping
US8852229B2 (en) 2003-10-17 2014-10-07 Cordis Corporation Locator and closure device and method of use
US7361183B2 (en) 2003-10-17 2008-04-22 Ensure Medical, Inc. Locator and delivery device and method of use
US8007514B2 (en) 2003-10-17 2011-08-30 St. Jude Medical Puerto Rico Llc Automatic suture locking device
US7326230B2 (en) 2003-10-23 2008-02-05 Sundaram Ravikumar Vascular sealing device and method of use
DE602004009335T2 (en) 2003-10-24 2008-07-03 ev3 Endovascular, Inc., Plymouth CLOSING SYSTEM FOR OPEN FORMS OVAL
IL158960A0 (en) 2003-11-19 2004-05-12 Neovasc Medical Ltd Vascular implant
CA2547999A1 (en) 2003-11-25 2005-06-09 Boston Scientific Limited Hemostatic pressure plug
US7731726B2 (en) 2003-12-03 2010-06-08 St. Jude Medical Puerto Rico Llc Suture based vascular closure apparatus and method incorporating a pre-tied knot
WO2005055801A2 (en) 2003-12-15 2005-06-23 By-Pass, Inc. Biodegradable closure device
US7717929B2 (en) 2003-12-19 2010-05-18 Radi Medical Systems Ab Technique for securing a suture
US7449024B2 (en) 2003-12-23 2008-11-11 Abbott Laboratories Suturing device with split arm and method of suturing tissue
US20070060950A1 (en) 2003-12-24 2007-03-15 Farhad Khosravi Apparatus and methods for delivering sealing materials during a percutaneous procedure to facilitate hemostasis
US20050245876A1 (en) 2003-12-24 2005-11-03 Accessclosure, Inc. Apparatus and methods for facilitating access through a puncture including sealing compound therein
US20050149117A1 (en) 2003-12-24 2005-07-07 Farhad Khosravi Apparatus and methods for delivering sealing materials during a percutaneous procedure to facilitate hemostasis
US7618427B2 (en) 2003-12-29 2009-11-17 Ethicon Endo-Surgery, Inc. Device and method for intralumenal anastomosis
US20050154401A1 (en) 2004-01-08 2005-07-14 Scimed Life Systems, Inc. Suturing device for implantable device
US20070053963A1 (en) 2004-01-13 2007-03-08 Hotchkiss Robert N Drug delivery to a joint
US7445596B2 (en) 2004-01-29 2008-11-04 Cannuflow, Inc. Atraumatic arthroscopic instrument sheath
EP1720595B1 (en) 2004-03-03 2011-05-11 C.R.Bard, Inc. Loop-tip catheter
WO2005092204A2 (en) 2004-03-22 2005-10-06 Accessclosure, Inc. Apparatus for sealing a vascular puncture
US20050267524A1 (en) 2004-04-09 2005-12-01 Nmt Medical, Inc. Split ends closure device
US9017374B2 (en) 2004-04-09 2015-04-28 Cardiva Medical, Inc. Device and method for sealing blood vessels
WO2005110240A1 (en) 2004-05-07 2005-11-24 Nmt Medical, Inc. Catching mechanisms for tubular septal occluder
US20050256532A1 (en) 2004-05-12 2005-11-17 Asha Nayak Cardiovascular defect patch device and method
WO2005115521A1 (en) 2004-05-14 2005-12-08 Medtronic, Inc. Medical tubing connector assembly incorporating strain relief sleeve
IES20040368A2 (en) 2004-05-25 2005-11-30 James E Coleman Surgical stapler
US7678135B2 (en) 2004-06-09 2010-03-16 Usgi Medical, Inc. Compressible tissue anchor assemblies
EP1611850A1 (en) 2004-06-28 2006-01-04 Cardio Life Research S.A. Occlusion and tight punction device for an anatomical structure
US7556632B2 (en) 2004-07-09 2009-07-07 Reza Zadno Device and method for repairing tissue
DE102004038823B3 (en) * 2004-08-04 2006-03-30 Aesculap Ag & Co. Kg Implant for fixing adjacent bone plates
US8992549B2 (en) 2004-08-05 2015-03-31 Teleflex Medical Incorporated Laparoscopic port site closure tool
US8348971B2 (en) 2004-08-27 2013-01-08 Accessclosure, Inc. Apparatus and methods for facilitating hemostasis within a vascular puncture
JP4786662B2 (en) 2004-09-27 2011-10-05 スーチュラ,インコーポレイテッド Suture device handle
US8262693B2 (en) 2004-11-05 2012-09-11 Accessclosure, Inc. Apparatus and methods for sealing a vascular puncture
US7582104B2 (en) 2004-12-08 2009-09-01 Cardia, Inc. Daisy design for occlusion device
US20060142784A1 (en) 2004-12-28 2006-06-29 Stavros Kontos Device and method for suturing internal structures puncture wounds
US20080114395A1 (en) 2005-01-14 2008-05-15 Radi Medical Systems Ab Closure Device
US8128640B2 (en) 2005-02-07 2012-03-06 Ivy Sports Medicine LLC System and method for all-inside suture fixation for implant attachment and soft tissue repair
US7931671B2 (en) 2005-03-11 2011-04-26 Radi Medical Systems Ab Medical sealing device
US7344544B2 (en) 2005-03-28 2008-03-18 Cardica, Inc. Vascular closure system
US8177741B2 (en) 2005-04-12 2012-05-15 Cook Medical Technologies Llc Catheter with superelastic retention device
WO2006115904A2 (en) 2005-04-22 2006-11-02 Accessclosure, Inc. Apparatus and methods for sealing a puncture in tissue
US8002742B2 (en) 2005-04-22 2011-08-23 Accessclosure, Inc. Apparatus and methods for sealing a puncture in tissue
WO2006117766A2 (en) 2005-04-29 2006-11-09 Zerusa Limited An interventional medical closure device
US8088144B2 (en) 2005-05-04 2012-01-03 Ensure Medical, Inc. Locator and closure device and method of use
US7622628B2 (en) 2005-05-04 2009-11-24 Innovasa Corporation Hemostatic wire guided bandage and method of use
USD566272S1 (en) 2005-05-19 2008-04-08 Integrated Vascular Systems, Inc. Vessel closure device
EP1903988A2 (en) 2005-06-07 2008-04-02 The International Heart Institute Of Montana Found A system, including method and apparatus for percutaneous endovascular treatment of functional mitral valve insufficiency
US20060293698A1 (en) 2005-06-28 2006-12-28 Medtronic Vascular, Inc. Retainer device for mitral valve leaflets
US20080312686A1 (en) 2005-07-01 2008-12-18 Abbott Laboratories Antimicrobial closure element and closure element applier
US8398703B2 (en) 2005-07-29 2013-03-19 Cvdevices, Llc Devices and methods for magnetic tissue support
US8029522B2 (en) 2005-08-05 2011-10-04 Ethicon Endo-Surgery, Inc. Method and apparatus for sealing a gastric opening
US8062309B2 (en) 2005-08-19 2011-11-22 Boston Scientific Scimed, Inc. Defect occlusion apparatus, system, and method
US20070060895A1 (en) 2005-08-24 2007-03-15 Sibbitt Wilmer L Jr Vascular closure methods and apparatuses
US8920442B2 (en) 2005-08-24 2014-12-30 Abbott Vascular Inc. Vascular opening edge eversion methods and apparatuses
US8758397B2 (en) 2005-08-24 2014-06-24 Abbott Vascular Inc. Vascular closure methods and apparatuses
WO2007025302A2 (en) 2005-08-26 2007-03-01 G-Surge Medical Solutions, Inc. Suturing apparatus and methods
US7846179B2 (en) 2005-09-01 2010-12-07 Ovalis, Inc. Suture-based systems and methods for treating septal defects
US7875041B2 (en) 2005-09-28 2011-01-25 Olympus Medical Systems Corp. Suturing method for penetrating hole
WO2007044510A1 (en) 2005-10-05 2007-04-19 Loma Linda University Medical Center Vascular wound closure device and method
US20070083231A1 (en) 2005-10-07 2007-04-12 Benjamin Lee Vascular closure
US10143456B2 (en) 2005-10-07 2018-12-04 Alex Javois Left atrial appendage occlusion device
US7850712B2 (en) 2005-11-15 2010-12-14 Ethicon Endo-Surgery, Inc. Self-shielding suture anchor
US20070112365A1 (en) 2005-11-15 2007-05-17 Applied Medical Resources Corporation Partial occlusion surgical guide clip
US20070167981A1 (en) 2005-12-22 2007-07-19 Nmt Medical, Inc. Catch members for occluder devices
US20070149996A1 (en) 2005-12-28 2007-06-28 Medtronic Vascular, Inc. Low profile filter
WO2007081836A1 (en) 2006-01-09 2007-07-19 Cook Incorporated Patent foramen ovale closure device and method
US20070172430A1 (en) 2006-01-20 2007-07-26 Nastech Pharmaceutical Company Inc. Dry powder compositions for rna influenza therapeutics
US8162974B2 (en) 2006-02-02 2012-04-24 Boston Scientific Scimed, Inc. Occlusion apparatus, system, and method
US7625392B2 (en) 2006-02-03 2009-12-01 James Coleman Wound closure devices and methods
WO2007092323A1 (en) 2006-02-07 2007-08-16 Sutura, Inc. Reverse tapered guidewire and method of use
US7824419B2 (en) 2006-02-09 2010-11-02 Sreevathsa Boraiah Laparoscopic trocar and facial closure systems and methods
US20070225755A1 (en) 2006-03-22 2007-09-27 Radi Medical Systems Ab Closure device
US20070225756A1 (en) 2006-03-22 2007-09-27 Radi Medical Systems Ab Closure device and insertion assembly
US20070225758A1 (en) 2006-03-22 2007-09-27 Radi Medical Systems Ab Closure device
US20070225757A1 (en) 2006-03-22 2007-09-27 Radi Medical Systems Ab Closure device
US8808310B2 (en) 2006-04-20 2014-08-19 Integrated Vascular Systems, Inc. Resettable clip applier and reset tools
US20070265658A1 (en) 2006-05-12 2007-11-15 Aga Medical Corporation Anchoring and tethering system
US20070275036A1 (en) 2006-05-18 2007-11-29 Celldyne Biopharma, Llc Avian follistatin product
US7850710B2 (en) 2006-05-23 2010-12-14 St. Jude Medical Puerto Rico Llc Puncture closure apparatuses, sealing plugs, and related methods
USD611144S1 (en) 2006-06-28 2010-03-02 Abbott Laboratories Apparatus for delivering a closure element
US20080033459A1 (en) 2006-08-03 2008-02-07 Surgsolutions, Llp Suturing apparatus for closing tissue defects
US20080215089A1 (en) 2006-09-21 2008-09-04 Williams Michael S Stomach wall closure devices
US8382653B2 (en) 2006-09-25 2013-02-26 Corassist Cardiovascular Ltd. Method and system for improving diastolic function of the heart
WO2008042627A1 (en) 2006-09-28 2008-04-10 Cook Critical Care Incorporated Bolster assembly
US8430906B2 (en) 2006-09-29 2013-04-30 St. Jude Medical, Cardiology Division, Inc. Method and apparatus to promote hemostasis
WO2008045703A2 (en) 2006-10-09 2008-04-17 Isik Frank F Vascular access devices and methods of use
US8834494B2 (en) 2006-10-20 2014-09-16 St. Jude Medical, Cardiology Division, Inc. Method and device for automated needle deployment
JP4584230B2 (en) 2006-11-14 2010-11-17 オリンパスメディカルシステムズ株式会社 Clip device
DE102006056283A1 (en) 2006-11-29 2008-06-05 Biomagnetik Park Gmbh Occlusion device for closing left heart auricle of patient, has cladding bag provided with fillable opening at its proximal end and partially made of thermoplastic polyurethane, where bag is partially filled with non-degradable plastic
WO2008074027A1 (en) 2006-12-13 2008-06-19 Biomerix Corporation Aneurysm occlusion devices
US20080177288A1 (en) 2007-01-19 2008-07-24 Carlson Mark A Remote Suturing Device
WO2008097967A2 (en) 2007-02-05 2008-08-14 Boston Scientific Limited Self-orientating suture wound closure device
US20080215090A1 (en) 2007-02-14 2008-09-04 Entrigue Surgical, Inc. Method and System for Tissue Fastening
US7533790B1 (en) 2007-03-08 2009-05-19 Cardica, Inc. Surgical stapler
US9545258B2 (en) 2007-05-17 2017-01-17 Boston Scientific Scimed, Inc. Tissue aperture securing and sealing apparatuses and related methods of use
CA2688261C (en) 2007-05-25 2013-04-30 Wilson-Cook Medical, Inc. Medical devices, systems and methods for closing perforations
US20080300628A1 (en) 2007-06-01 2008-12-04 Abbott Laboratories Medical Devices
US7967842B2 (en) 2007-06-01 2011-06-28 Ethicon Endo-Surgery, Inc. Integrated securement and closure apparatus
US8574244B2 (en) 2007-06-25 2013-11-05 Abbott Laboratories System for closing a puncture in a vessel wall
US8226681B2 (en) 2007-06-25 2012-07-24 Abbott Laboratories Methods, devices, and apparatus for managing access through tissue
US7771455B2 (en) * 2007-08-31 2010-08-10 Ken Christopher G M Closure medical device
US7875054B2 (en) 2007-10-01 2011-01-25 Boston Scientific Scimed, Inc. Connective tissue closure device and method
US8142490B2 (en) 2007-10-24 2012-03-27 Cordis Corporation Stent segments axially connected by thin film
US8980299B2 (en) 2007-10-31 2015-03-17 Cordis Corporation Method of making a vascular closure device
US8016880B2 (en) 2007-11-16 2011-09-13 Medtronic Vascular, Inc. Stent having spiral channel for drug delivery
US20090157101A1 (en) 2007-12-17 2009-06-18 Abbott Laboratories Tissue closure system and methods of use
US8893947B2 (en) 2007-12-17 2014-11-25 Abbott Laboratories Clip applier and methods of use
US7841502B2 (en) 2007-12-18 2010-11-30 Abbott Laboratories Modular clip applier
US20090187215A1 (en) 2007-12-19 2009-07-23 Abbott Laboratories Methods and apparatus to reduce a dimension of an implantable device in a smaller state
US20090216267A1 (en) 2008-02-26 2009-08-27 Boston Scientific Scimed, Inc. Closure device with rapidly dissolving anchor
AU2009222028A1 (en) 2008-03-03 2009-09-11 Applied Medical Resources Corporation Balloon trocar advanced fixation
US20090227938A1 (en) 2008-03-05 2009-09-10 Insitu Therapeutics, Inc. Wound Closure Devices, Methods of Use, and Kits
US8864776B2 (en) 2008-04-11 2014-10-21 Covidien Lp Deployment system for surgical suture
US8241305B2 (en) 2008-05-08 2012-08-14 Biomet Sports Medicine, Llc Method for repairing a meniscal tear
US9282965B2 (en) 2008-05-16 2016-03-15 Abbott Laboratories Apparatus and methods for engaging tissue
US8409228B2 (en) 2008-06-06 2013-04-02 Duane D. Blatter Tissue management methods, apparatus, and systems
US8562630B2 (en) 2008-07-18 2013-10-22 Richard Campbell Suture instrument and method
US8574245B2 (en) 2008-08-13 2013-11-05 Silk Road Medical, Inc. Suture delivery device
EP2323566A2 (en) 2008-08-13 2011-05-25 Silk Road Medical, Inc. Suture delivery device
AU2009289474B2 (en) 2008-09-04 2015-09-03 Curaseal Inc. Inflatable devices for enteric fistula treatment
DE102008053809A1 (en) 2008-10-29 2010-05-12 Medi-Globe Gmbh Surgical thread positioning system for closing an opening within a tissue wall
US8398676B2 (en) 2008-10-30 2013-03-19 Abbott Vascular Inc. Closure device
US8323312B2 (en) 2008-12-22 2012-12-04 Abbott Laboratories Closure device
US8858594B2 (en) 2008-12-22 2014-10-14 Abbott Laboratories Curved closure device
US9414820B2 (en) 2009-01-09 2016-08-16 Abbott Vascular Inc. Closure devices, systems, and methods
US20130310853A1 (en) 2009-01-09 2013-11-21 Abbott Cardiovascular Systems Inc. Method and apparatus for percutaneous treatment of a blood vessel
US20100179567A1 (en) 2009-01-09 2010-07-15 Abbott Vascular Inc. Closure devices, systems, and methods
US9089311B2 (en) 2009-01-09 2015-07-28 Abbott Vascular Inc. Vessel closure devices and methods
US20110218568A1 (en) 2009-01-09 2011-09-08 Voss Laveille K Vessel closure devices, systems, and methods
US9173644B2 (en) 2009-01-09 2015-11-03 Abbott Vascular Inc. Closure devices, systems, and methods
US20100179589A1 (en) 2009-01-09 2010-07-15 Abbott Vascular Inc. Rapidly eroding anchor
US9486191B2 (en) 2009-01-09 2016-11-08 Abbott Vascular, Inc. Closure devices
US20100185234A1 (en) 2009-01-16 2010-07-22 Abbott Vascular Inc. Closure devices, systems, and methods
US20140081318A1 (en) 2009-04-09 2014-03-20 CardioVascular Technologies, Inc Tissue closure devices, device and systems for delivery, kits and methods therefor
US20110054492A1 (en) 2009-08-26 2011-03-03 Abbott Laboratories Medical device for repairing a fistula
US20110082495A1 (en) 2009-10-02 2011-04-07 Ruiz Carlos E Apparatus And Methods For Excluding The Left Atrial Appendage
WO2011053673A1 (en) 2009-10-30 2011-05-05 Wilson-Cook Medical Inc. Apparatus and methods for achieving serosa-to-serosa closure of a bodily opening
WO2011094619A1 (en) 2010-01-29 2011-08-04 Med-Venture Investments, Llc Methods and apparatuses for suturing of cardiac openings
US8303624B2 (en) 2010-03-15 2012-11-06 Abbott Cardiovascular Systems, Inc. Bioabsorbable plug
US8758399B2 (en) 2010-08-02 2014-06-24 Abbott Cardiovascular Systems, Inc. Expandable bioabsorbable plug apparatus and method
US8603116B2 (en) 2010-08-04 2013-12-10 Abbott Cardiovascular Systems, Inc. Closure device with long tines
US8617184B2 (en) 2011-02-15 2013-12-31 Abbott Cardiovascular Systems, Inc. Vessel closure system
US8821529B2 (en) 2011-03-25 2014-09-02 Aga Medical Corporation Device and method for occluding a septal defect
US8556932B2 (en) 2011-05-19 2013-10-15 Abbott Cardiovascular Systems, Inc. Collapsible plug for tissue closure
US20130053792A1 (en) 2011-08-24 2013-02-28 Ablative Solutions, Inc. Expandable catheter system for vessel wall injection and muscle and nerve fiber ablation
US9332976B2 (en) 2011-11-30 2016-05-10 Abbott Cardiovascular Systems, Inc. Tissue closure device
US9364209B2 (en) 2012-12-21 2016-06-14 Abbott Cardiovascular Systems, Inc. Articulating suturing device

Patent Citations (111)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1088393A (en) * 1913-09-20 1914-02-24 Oscar E Backus Button.
US1331401A (en) * 1919-09-12 1920-02-17 Summers Henry Clay Button-fastening
US1480935A (en) * 1922-04-03 1924-01-15 Dora P Gleason Barrette
US2583625A (en) * 1946-10-29 1952-01-29 Thomas & Betts Corp Method of and tool for crimping tubes
US2969867A (en) * 1952-08-12 1961-01-31 Filper Corp Fruit transfer apparatus
US3015403A (en) * 1959-04-08 1962-01-02 American Thermos Products Comp Threaded stopper expanding pouring lip combination for vacuum bottle
US3120230A (en) * 1960-10-24 1964-02-04 Jack H Sanders Surgical clamp
US3494533A (en) * 1966-10-10 1970-02-10 United States Surgical Corp Surgical stapler for stitching body organs
US3939820A (en) * 1974-10-29 1976-02-24 Datascope Corporation Single-chamber, multi-section balloon for cardiac assistance
US4007743A (en) * 1975-10-20 1977-02-15 American Hospital Supply Corporation Opening mechanism for umbrella-like intravascular shunt defect closure device
US4189808A (en) * 1978-09-20 1980-02-26 Brown Theodore G Retainer and closure for a garbage can liner bag
US4428376A (en) * 1980-05-02 1984-01-31 Ethicon Inc. Plastic surgical staple
US4368736A (en) * 1980-11-17 1983-01-18 Kaster Robert L Anastomotic fitting
US4724840A (en) * 1982-02-03 1988-02-16 Ethicon, Inc. Surgical fastener applier with rotatable front housing and laterally extending curved needle for guiding a flexible pusher
US4635634A (en) * 1985-07-12 1987-01-13 Santos Manuel V Surgical clip applicator system
US4719917A (en) * 1987-02-17 1988-01-19 Minnesota Mining And Manufacturing Company Surgical staple
US4890612A (en) * 1987-02-17 1990-01-02 Kensey Nash Corporation Device for sealing percutaneous puncture in a vessel
USRE34866E (en) * 1987-02-17 1995-02-21 Kensey Nash Corporation Device for sealing percutaneous puncture in a vessel
US4902508A (en) * 1988-07-11 1990-02-20 Purdue Research Foundation Tissue graft composition
US4983176A (en) * 1989-03-06 1991-01-08 University Of New Mexico Deformable plastic surgical clip
US5078731A (en) * 1990-06-05 1992-01-07 Hayhurst John O Suture clip
US5591205A (en) * 1990-10-01 1997-01-07 Quinton Instrument Company Insertion assembly and method of inserting a vessel plug into the body of a patient
US5275616B1 (en) * 1990-10-01 1996-01-23 Quinton Instr Insertion assembly and method of inserting a vessel plug into the body of a patient
US5716375A (en) * 1990-10-01 1998-02-10 Quinton Instrument Company Insertion assembly and method of inserting a vessel plug into the body of a patient
US5601602A (en) * 1990-10-01 1997-02-11 Quinton Instrument Company Insertion assembly and method of inserting a vessel plug into the body of a patient
US5275616A (en) * 1990-10-01 1994-01-04 Quinton Instrument Company Insertion assembly and method of inserting a vessel plug into the body of a patient
US5392978A (en) * 1991-02-08 1995-02-28 United States Surgical Corporation Surgical staple and endoscopic stapler
US5281422A (en) * 1991-09-24 1994-01-25 Purdue Research Foundation Graft for promoting autogenous tissue growth
US5282827A (en) * 1991-11-08 1994-02-01 Kensey Nash Corporation Hemostatic puncture closure system and method of use
US5176648A (en) * 1991-12-13 1993-01-05 Unisurge, Inc. Introducer assembly and instrument for use therewith
US5871525A (en) * 1992-04-13 1999-02-16 Ep Technologies, Inc. Steerable ablation catheter system
US5282808A (en) * 1992-05-26 1994-02-01 Origin Medsystems, Inc. Closure prevention apparatus for surgical clip applier
US5383897A (en) * 1992-10-19 1995-01-24 Shadyside Hospital Method and apparatus for closing blood vessel punctures
US5860991A (en) * 1992-12-10 1999-01-19 Perclose, Inc. Method for the percutaneous suturing of a vascular puncture site
US5383896A (en) * 1993-05-25 1995-01-24 Gershony; Gary Vascular sealing device
US5486195A (en) * 1993-07-26 1996-01-23 Myers; Gene Method and apparatus for arteriotomy closure
US5871501A (en) * 1994-01-18 1999-02-16 Datascope Investment Corp. Guide wire with releasable barb anchor
US5593412A (en) * 1994-03-01 1997-01-14 Cordis Corporation Stent delivery method and apparatus
US5715987A (en) * 1994-04-05 1998-02-10 Tracor Incorporated Constant width, adjustable grip, staple apparatus and method
US5873891A (en) * 1994-12-14 1999-02-23 Influence Medical Technologies, Ltd. Staple and thread assembly particularly for use in power-driven staplers for medical suturing
US6171329B1 (en) * 1994-12-19 2001-01-09 Gore Enterprise Holdings, Inc. Self-expanding defect closure device and method of making and using
US5720755A (en) * 1995-01-18 1998-02-24 Dakov; Pepi Tubular suturing device and methods of use
US6984238B2 (en) * 1995-02-24 2006-01-10 Gifford Iii Hanson S Devices and methods for performing avascular anastomosis
US5713899A (en) * 1995-04-27 1998-02-03 Societe Jbs Sa Cervical cage designed for the performance of intersomatic arthrodesis
US5871474A (en) * 1995-05-19 1999-02-16 General Surgical Innovations, Inc. Screw-type skin seal with inflatable membrane
US5709224A (en) * 1995-06-07 1998-01-20 Radiotherapeutics Corporation Method and device for permanent vessel occlusion
US6013084A (en) * 1995-06-30 2000-01-11 Target Therapeutics, Inc. Stretch resistant vaso-occlusive coils (II)
US6010517A (en) * 1996-04-10 2000-01-04 Baccaro; Jorge Alberto Device for occluding abnormal vessel communications
US7169158B2 (en) * 1996-07-23 2007-01-30 Tyco Healthcare Group Lp Anastomosis instrument and method for performing same
US5855312A (en) * 1996-07-25 1999-01-05 Toledano; Haviv Flexible annular stapler for closed surgery of hollow organs
US5868763A (en) * 1996-09-16 1999-02-09 Guidant Corporation Means and methods for performing an anastomosis
US5873876A (en) * 1996-09-23 1999-02-23 Christy; William J. Surgical loop delivery device and method
US20030004543A1 (en) * 1996-10-17 2003-01-02 Malachy Gleeson Device for closure of puncture wound
US6679904B2 (en) * 1996-10-17 2004-01-20 Malachy Gleeson Device for closure of puncture wound
US5861003A (en) * 1996-10-23 1999-01-19 The Cleveland Clinic Foundation Apparatus and method for occluding a defect or aperture within body surface
US5868755A (en) * 1997-01-16 1999-02-09 Atrion Medical Products, Inc. Sheath retractor mechanism and method
US5861005A (en) * 1997-02-11 1999-01-19 X-Site, L.L.C. Arterial stapling device
US6022372A (en) * 1997-02-11 2000-02-08 X-Site, L.L.C. Arterial stapling device
US6174322B1 (en) * 1997-08-08 2001-01-16 Cardia, Inc. Occlusion device for the closure of a physical anomaly such as a vascular aperture or an aperture in a septum
US6024750A (en) * 1997-08-14 2000-02-15 United States Surgical Ultrasonic curved blade
US5858082A (en) * 1997-09-15 1999-01-12 Cruz; Hector Gonzalo Self-interlocking reinforcement fibers
US5868762A (en) * 1997-09-25 1999-02-09 Sub-Q, Inc. Percutaneous hemostatic suturing device and method
US6015815A (en) * 1997-09-26 2000-01-18 Abbott Laboratories Tetrazole-containing rapamycin analogs with shortened half-lives
US6171277B1 (en) * 1997-12-01 2001-01-09 Cordis Webster, Inc. Bi-directional control handle for steerable catheter
US6626919B1 (en) * 1997-12-29 2003-09-30 Lee L. Swanstrom Method and apparatus for attaching or locking an implant to an anatomic vessel or hollow organ wall
US20030023248A1 (en) * 1998-03-13 2003-01-30 Parodi Juan C. Systems and methods for applying a suture within a blood vesel lumen
US6989016B2 (en) * 1998-07-22 2006-01-24 Medtronic Angiolink, Inc. Vascular suction cannula, dilator and surgical stapler
US6334865B1 (en) * 1998-08-04 2002-01-01 Fusion Medical Technologies, Inc. Percutaneous tissue track closure assembly and method
US20040009205A1 (en) * 1998-08-14 2004-01-15 Incept Llc Methods of using in situ hydration of hydrogel articles for sealing or augmentation of tissue or vessels
US6179860B1 (en) * 1998-08-19 2001-01-30 Artemis Medical, Inc. Target tissue localization device and method
US6676671B2 (en) * 1998-09-15 2004-01-13 United States Surgical Stapling apparatus and method for heart valve replacement
US6019779A (en) * 1998-10-09 2000-02-01 Intratherapeutics Inc. Multi-filar coil medical stent
US6676685B2 (en) * 1999-02-22 2004-01-13 Tyco Healthcare Group Lp Arterial hole closure apparatus
US6179849B1 (en) * 1999-06-10 2001-01-30 Vascular Innovations, Inc. Sutureless closure for connecting a bypass graft to a target vessel
US20030018358A1 (en) * 1999-06-25 2003-01-23 Vahid Saadat Apparatus and methods for treating tissue
US20030009180A1 (en) * 1999-09-13 2003-01-09 Hinchliffe Peter W.J. Vascular hole closure device
US6673083B1 (en) * 1999-11-29 2004-01-06 General Surgical Innovations, Inc. Method for blood vessel clip application
US20020198562A1 (en) * 2000-04-19 2002-12-26 Radi Medical Systems Ab Reinforced absorbable medical sealing device
US6837893B2 (en) * 2000-09-01 2005-01-04 Onux Medical, Inc. Multi-fastener surgical apparatus and method
US6506210B1 (en) * 2000-09-01 2003-01-14 Angiolink Corporation Wound site management and wound closure device
US7169164B2 (en) * 2000-09-21 2007-01-30 Atritech, Inc. Apparatus for implanting devices in atrial appendages
US20070010853A1 (en) * 2000-10-06 2007-01-11 Integrated Vascular Systems, Inc. Apparatus and methods for positioning a vascular sheath
US6508828B1 (en) * 2000-11-03 2003-01-21 Radi Medical Systems Ab Sealing device and wound closure device
US20040009289A1 (en) * 2000-12-07 2004-01-15 Carley Michael T. Closure device and methods for making and using them
US6846319B2 (en) * 2000-12-14 2005-01-25 Core Medical, Inc. Devices for sealing openings through tissue and apparatus and methods for delivering them
US20020183787A1 (en) * 2001-06-01 2002-12-05 Velocimed, L.L.C. Closure devices, related delivery methods and tools, and related methods of use
US20070010854A1 (en) * 2001-06-07 2007-01-11 Christy Cummins Surgical Staple
US20030060846A1 (en) * 2001-06-15 2003-03-27 Radi Medical Systems Ab Tamping mechanism
US6837906B2 (en) * 2001-08-03 2005-01-04 Ensure Medical, Inc. Lung assist apparatus and methods for use
US7163551B2 (en) * 2001-08-09 2007-01-16 Thomas Anthony Surgical stapling device
US6989003B2 (en) * 2001-08-31 2006-01-24 Conmed Corporation Obturator and cannula for a trocar adapted for ease of insertion and removal
US6685707B2 (en) * 2001-09-25 2004-02-03 Walter Lorenz Surgical, Inc. Cranial clamp and method for fixating a bone plate
US20030093108A1 (en) * 2001-11-15 2003-05-15 Ernesto Avellanet Aneurysm neck cover for sealing an aneurysm
US7322995B2 (en) * 2002-09-13 2008-01-29 Damage Control Surgical Technologies, Inc. Method and apparatus for vascular and visceral clipping
US7867249B2 (en) * 2003-01-30 2011-01-11 Integrated Vascular Systems, Inc. Clip applier and methods of use
US7316704B2 (en) * 2003-06-04 2008-01-08 Accessclosure, Inc. Occlusion member and tensioner apparatus and methods of their use for sealing a vascular puncture
US7316706B2 (en) * 2003-06-20 2008-01-08 Medtronic Vascular, Inc. Tensioning device, system, and method for treating mitral valve regurgitation
US20050203552A1 (en) * 2004-03-11 2005-09-15 Laufer Michael D. Surgical fastening system
US7645285B2 (en) * 2004-05-26 2010-01-12 Idx Medical, Ltd Apparatus and methods for occluding a hollow anatomical structure
US8105352B2 (en) * 2004-12-16 2012-01-31 Radi Medical Systems Ab Medical sealing device
US20080009794A1 (en) * 2005-04-22 2008-01-10 Accessclosure, Inc. Apparatus and method for temporary hemostasis
US20070021778A1 (en) * 2005-06-24 2007-01-25 Abbott Laboratories Abbott Vascular Devices Apparatus and method for delivering a closure element
US20080004636A1 (en) * 2005-07-01 2008-01-03 Abbott Laboratories Clip applier and methods of use
US20070005093A1 (en) * 2005-07-01 2007-01-04 Cox John A System for tissue dissection and retraction
US20130006274A1 (en) * 2005-07-01 2013-01-03 Abbott Laboratories Clip applier and methods of use
US20070185530A1 (en) * 2005-09-01 2007-08-09 Chao Chin-Chen Patent foramen ovale closure method
US20080004640A1 (en) * 2006-06-28 2008-01-03 Abbott Laboratories Vessel closure device
US20080091235A1 (en) * 2006-10-11 2008-04-17 Sirota Daniel J Closure device with biomaterial patches
US20080243182A1 (en) * 2007-03-29 2008-10-02 Datascope Investment Corp. Vascular hemostasis device and deployment apparatus
US8103327B2 (en) * 2007-12-28 2012-01-24 Rhythmia Medical, Inc. Cardiac mapping catheter
US20100042144A1 (en) * 2008-08-12 2010-02-18 Steven Bennett Medical Device for Wound Closure and Method of Use

Cited By (113)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8758396B2 (en) 2000-01-05 2014-06-24 Integrated Vascular Systems, Inc. Vascular sheath with bioabsorbable puncture site closure apparatus and methods of use
US10111664B2 (en) 2000-01-05 2018-10-30 Integrated Vascular Systems, Inc. Closure system and methods of use
US7901428B2 (en) 2000-01-05 2011-03-08 Integrated Vascular Systems, Inc. Vascular sheath with bioabsorbable puncture site closure apparatus and methods of use
US9579091B2 (en) 2000-01-05 2017-02-28 Integrated Vascular Systems, Inc. Closure system and methods of use
US7931669B2 (en) 2000-01-05 2011-04-26 Integrated Vascular Systems, Inc. Integrated vascular device with puncture site closure component and sealant and methods of use
US9050087B2 (en) 2000-01-05 2015-06-09 Integrated Vascular Systems, Inc. Integrated vascular device with puncture site closure component and sealant and methods of use
US8956388B2 (en) 2000-01-05 2015-02-17 Integrated Vascular Systems, Inc. Integrated vascular device with puncture site closure component and sealant
US8758400B2 (en) 2000-01-05 2014-06-24 Integrated Vascular Systems, Inc. Closure system and methods of use
US9402625B2 (en) 2000-09-08 2016-08-02 Abbott Vascular Inc. Surgical stapler
US9060769B2 (en) 2000-09-08 2015-06-23 Abbott Vascular Inc. Surgical stapler
US8784447B2 (en) 2000-09-08 2014-07-22 Abbott Vascular Inc. Surgical stapler
US9089674B2 (en) 2000-10-06 2015-07-28 Integrated Vascular Systems, Inc. Apparatus and methods for positioning a vascular sheath
US9585646B2 (en) 2000-12-07 2017-03-07 Integrated Vascular Systems, Inc. Closure device and methods for making and using them
US8486108B2 (en) 2000-12-07 2013-07-16 Integrated Vascular Systems, Inc. Closure device and methods for making and using them
US8236026B2 (en) 2000-12-07 2012-08-07 Integrated Vascular Systems, Inc. Closure device and methods for making and using them
US8257390B2 (en) 2000-12-07 2012-09-04 Integrated Vascular Systems, Inc. Closure device and methods for making and using them
US9320522B2 (en) 2000-12-07 2016-04-26 Integrated Vascular Systems, Inc. Closure device and methods for making and using them
US8182497B2 (en) 2000-12-07 2012-05-22 Integrated Vascular Systems, Inc. Closure device
US8128644B2 (en) 2000-12-07 2012-03-06 Integrated Vascular Systems, Inc. Closure device and methods for making and using them
US10245013B2 (en) 2000-12-07 2019-04-02 Integrated Vascular Systems, Inc. Closure device and methods for making and using them
US8690910B2 (en) 2000-12-07 2014-04-08 Integrated Vascular Systems, Inc. Closure device and methods for making and using them
US8603136B2 (en) 2000-12-07 2013-12-10 Integrated Vascular Systems, Inc. Apparatus and methods for providing tactile feedback while delivering a closure device
US7887555B2 (en) 2000-12-07 2011-02-15 Integrated Vascular Systems, Inc. Closure device and methods for making and using them
US9554786B2 (en) 2000-12-07 2017-01-31 Integrated Vascular Systems, Inc. Closure device and methods for making and using them
US8486092B2 (en) 2000-12-07 2013-07-16 Integrated Vascular Systems, Inc. Closure device and methods for making and using them
US8597325B2 (en) 2000-12-07 2013-12-03 Integrated Vascular Systems, Inc. Apparatus and methods for providing tactile feedback while delivering a closure device
US7879071B2 (en) 2000-12-07 2011-02-01 Integrated Vascular Systems, Inc. Closure device and methods for making and using them
US7918873B2 (en) 2001-06-07 2011-04-05 Abbott Vascular Inc. Surgical staple
US8728119B2 (en) 2001-06-07 2014-05-20 Abbott Vascular Inc. Surgical staple
US8579932B2 (en) 2002-02-21 2013-11-12 Integrated Vascular Systems, Inc. Sheath apparatus and methods for delivering a closure device
US9498196B2 (en) 2002-02-21 2016-11-22 Integrated Vascular Systems, Inc. Sheath apparatus and methods for delivering a closure device
US8007512B2 (en) 2002-02-21 2011-08-30 Integrated Vascular Systems, Inc. Plunger apparatus and methods for delivering a closure device
US10201340B2 (en) 2002-02-21 2019-02-12 Integrated Vascular Systems, Inc. Sheath apparatus and methods for delivering a closure device
US9295469B2 (en) 2002-06-04 2016-03-29 Abbott Vascular Inc. Blood vessel closure clip and delivery device
US9980728B2 (en) 2002-06-04 2018-05-29 Abbott Vascular Inc Blood vessel closure clip and delivery device
US8469995B2 (en) 2002-06-04 2013-06-25 Abbott Vascular Inc. Blood vessel closure clip and delivery device
US8192459B2 (en) 2002-06-04 2012-06-05 Abbott Vascular Inc. Blood vessel closure clip and delivery device
US8585836B2 (en) 2002-12-31 2013-11-19 Integrated Vascular Systems, Inc. Methods for manufacturing a clip and clip
US8202283B2 (en) 2002-12-31 2012-06-19 Integrated Vascular Systems, Inc. Methods for manufacturing a clip and clip
US8202293B2 (en) 2003-01-30 2012-06-19 Integrated Vascular Systems, Inc. Clip applier and methods of use
US8926656B2 (en) 2003-01-30 2015-01-06 Integated Vascular Systems, Inc. Clip applier and methods of use
US9398914B2 (en) 2003-01-30 2016-07-26 Integrated Vascular Systems, Inc. Methods of use of a clip applier
US8529587B2 (en) 2003-01-30 2013-09-10 Integrated Vascular Systems, Inc. Methods of use of a clip applier
US8202294B2 (en) 2003-01-30 2012-06-19 Integrated Vascular Systems, Inc. Clip applier and methods of use
US9271707B2 (en) 2003-01-30 2016-03-01 Integrated Vascular Systems, Inc. Clip applier and methods of use
US8398656B2 (en) 2003-01-30 2013-03-19 Integrated Vascular Systems, Inc. Clip applier and methods of use
US10398418B2 (en) 2003-01-30 2019-09-03 Integrated Vascular Systems, Inc. Clip applier and methods of use
US11589856B2 (en) 2003-01-30 2023-02-28 Integrated Vascular Systems, Inc. Clip applier and methods of use
US8590760B2 (en) 2004-05-25 2013-11-26 Abbott Vascular Inc. Surgical stapler
US11744576B2 (en) 2005-06-20 2023-09-05 Scarab Technology Services, Llc Method and apparatus for applying a knot to a suture
US8926633B2 (en) 2005-06-24 2015-01-06 Abbott Laboratories Apparatus and method for delivering a closure element
US10085753B2 (en) 2005-07-01 2018-10-02 Abbott Laboratories Clip applier and methods of use
US11344304B2 (en) 2005-07-01 2022-05-31 Abbott Laboratories Clip applier and methods of use
US8518057B2 (en) 2005-07-01 2013-08-27 Abbott Laboratories Clip applier and methods of use
US9050068B2 (en) 2005-07-01 2015-06-09 Abbott Laboratories Clip applier and methods of use
US8313497B2 (en) 2005-07-01 2012-11-20 Abbott Laboratories Clip applier and methods of use
US9456811B2 (en) 2005-08-24 2016-10-04 Abbott Vascular Inc. Vascular closure methods and apparatuses
US8920442B2 (en) 2005-08-24 2014-12-30 Abbott Vascular Inc. Vascular opening edge eversion methods and apparatuses
US8808310B2 (en) 2006-04-20 2014-08-19 Integrated Vascular Systems, Inc. Resettable clip applier and reset tools
US8556930B2 (en) 2006-06-28 2013-10-15 Abbott Laboratories Vessel closure device
US9962144B2 (en) 2006-06-28 2018-05-08 Abbott Laboratories Vessel closure device
US8758398B2 (en) 2006-09-08 2014-06-24 Integrated Vascular Systems, Inc. Apparatus and method for delivering a closure element
US8226681B2 (en) 2007-06-25 2012-07-24 Abbott Laboratories Methods, devices, and apparatus for managing access through tissue
US8672953B2 (en) 2007-12-17 2014-03-18 Abbott Laboratories Tissue closure system and methods of use
US8893947B2 (en) 2007-12-17 2014-11-25 Abbott Laboratories Clip applier and methods of use
US8820602B2 (en) 2007-12-18 2014-09-02 Abbott Laboratories Modular clip applier
US10413295B2 (en) 2008-05-16 2019-09-17 Abbott Laboratories Engaging element for engaging tissue
US9282965B2 (en) 2008-05-16 2016-03-15 Abbott Laboratories Apparatus and methods for engaging tissue
US9993235B2 (en) 2008-09-04 2018-06-12 Curaseal Inc. Enteric fistula treatment devices
US9241696B2 (en) 2008-10-30 2016-01-26 Abbott Vascular Inc. Closure device
US8657852B2 (en) 2008-10-30 2014-02-25 Abbott Vascular Inc. Closure device
US8398676B2 (en) 2008-10-30 2013-03-19 Abbott Vascular Inc. Closure device
US8858594B2 (en) 2008-12-22 2014-10-14 Abbott Laboratories Curved closure device
US8323312B2 (en) 2008-12-22 2012-12-04 Abbott Laboratories Closure device
US9089311B2 (en) 2009-01-09 2015-07-28 Abbott Vascular Inc. Vessel closure devices and methods
US10537313B2 (en) 2009-01-09 2020-01-21 Abbott Vascular, Inc. Closure devices and methods
US9314230B2 (en) 2009-01-09 2016-04-19 Abbott Vascular Inc. Closure device with rapidly eroding anchor
US9414820B2 (en) 2009-01-09 2016-08-16 Abbott Vascular Inc. Closure devices, systems, and methods
US11439378B2 (en) 2009-01-09 2022-09-13 Abbott Cardiovascular Systems, Inc. Closure devices and methods
US9486191B2 (en) 2009-01-09 2016-11-08 Abbott Vascular, Inc. Closure devices
US9173644B2 (en) 2009-01-09 2015-11-03 Abbott Vascular Inc. Closure devices, systems, and methods
US9414824B2 (en) 2009-01-16 2016-08-16 Abbott Vascular Inc. Closure devices, systems, and methods
US8905937B2 (en) 2009-02-26 2014-12-09 Integrated Vascular Systems, Inc. Methods and apparatus for locating a surface of a body lumen
US9585647B2 (en) 2009-08-26 2017-03-07 Abbott Laboratories Medical device for repairing a fistula
US8303624B2 (en) 2010-03-15 2012-11-06 Abbott Cardiovascular Systems, Inc. Bioabsorbable plug
US8758399B2 (en) 2010-08-02 2014-06-24 Abbott Cardiovascular Systems, Inc. Expandable bioabsorbable plug apparatus and method
US8603116B2 (en) 2010-08-04 2013-12-10 Abbott Cardiovascular Systems, Inc. Closure device with long tines
WO2012047815A3 (en) * 2010-10-04 2012-06-14 The Johns Hopkins University Method and device for closure of intraluminal perforations
US8821534B2 (en) 2010-12-06 2014-09-02 Integrated Vascular Systems, Inc. Clip applier having improved hemostasis and methods of use
US9149276B2 (en) 2011-03-21 2015-10-06 Abbott Cardiovascular Systems, Inc. Clip and deployment apparatus for tissue closure
US9211116B2 (en) 2011-06-16 2015-12-15 Curaseal Inc. Fistula treatment devices and related methods
EP2720625A4 (en) * 2011-06-16 2015-02-18 Curaseal Inc Fistula treatment devices and related methods
WO2012174469A2 (en) 2011-06-16 2012-12-20 Curaseal Inc. Fistula treatment devices and related methods
EP2720625A2 (en) * 2011-06-16 2014-04-23 Curaseal Inc. Fistula treatment devices and related methods
US9131941B2 (en) 2011-06-17 2015-09-15 Curaseal Inc. Fistula treatment devices and methods
US20130123844A1 (en) * 2011-11-16 2013-05-16 St. Jude Medical Puerto Rico Llc Large bore closure device with inner and outer seals
US10751035B2 (en) * 2011-11-16 2020-08-25 St. Jude Medical Puerto Rico Llc Large bore closure device with inner and outer seals
US9332976B2 (en) 2011-11-30 2016-05-10 Abbott Cardiovascular Systems, Inc. Tissue closure device
US10537312B2 (en) 2012-12-21 2020-01-21 Abbott Cardiovascular Systems, Inc. Articulating suturing device
US9364209B2 (en) 2012-12-21 2016-06-14 Abbott Cardiovascular Systems, Inc. Articulating suturing device
US11672518B2 (en) 2012-12-21 2023-06-13 Abbott Cardiovascular Systems, Inc. Articulating suturing device
US20140222064A1 (en) * 2013-02-01 2014-08-07 St. Jude Medical Puerto Rico Llc Dual lumen carrier tube with retractable sleeve and methods
US9131932B2 (en) * 2013-02-01 2015-09-15 St. Jude Medical Puerto Rico Llc Dual lumen carrier tube with retractable sleeve and methods
US10154835B2 (en) 2013-05-09 2018-12-18 Essential Medical, Inc. Vascular closure device with conforming plug member
US11779324B2 (en) 2013-12-06 2023-10-10 Med-Venture Investments, Llc Suturing methods and apparatuses
US11395658B2 (en) * 2014-07-11 2022-07-26 Cardio Medical Solutions, Inc. Device and method for assisting end-to-side anastomosis
US20200237354A1 (en) * 2015-06-30 2020-07-30 Unity Health Toronto Cardiac injury device
US11553905B2 (en) * 2015-06-30 2023-01-17 Unity Health Toronto Cardiac injury device
US11185318B2 (en) 2016-06-16 2021-11-30 Phillips Medical, LLC Methods and systems for sealing a puncture of a vessel
US11751860B2 (en) 2016-06-16 2023-09-12 Phillips Medical, LLC Methods and systems for sealing a puncture of a vessel
US10448938B2 (en) 2016-06-16 2019-10-22 Phillips Medical, LLC Methods and systems for sealing a puncture of a vessel
US10716551B2 (en) 2017-05-12 2020-07-21 Phillips Medical, LLC Systems and methods for sealing a puncture of a vessel
US10624620B2 (en) 2017-05-12 2020-04-21 Phillips Medical, LLC Systems and methods for sealing a puncture of a vessel

Also Published As

Publication number Publication date
US9414824B2 (en) 2016-08-16
US20140364900A1 (en) 2014-12-11

Similar Documents

Publication Publication Date Title
US9414824B2 (en) Closure devices, systems, and methods
US11647997B2 (en) Suturing devices and methods
US8845682B2 (en) Vasculature closure devices and methods
US9055932B2 (en) Suture fastener combination device
AU2006333048B2 (en) Systems for closing a vessel wound
US20150094759A1 (en) Vasculature closure devices and methods
US9782155B2 (en) Vascular hole closure device
US20050203550A1 (en) Surgical fastener
JP6641378B2 (en) Closure device for sealing a percutaneous opening in a vessel
EP2449972B1 (en) Vascular hole closure delivery device
JP2011005270A (en) Access and closure device and method
KR20080110741A (en) Wound closure devices
US9414822B2 (en) Tissue eversion apparatus and tissue closure device and methods for use thereof
US20110106131A1 (en) Systems and Methods for Closing a Percutaneous Vascular Puncture
EP1701751B1 (en) Improved ferrule

Legal Events

Date Code Title Description
AS Assignment

Owner name: ABBOTT VASCULAR INC, CALIFORNIA

Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNORS:FORTSON, AARON M.;ROORDA, WOUTER E.;REEL/FRAME:033242/0001

Effective date: 20100114

STCB Information on status: application discontinuation

Free format text: ABANDONED -- FAILURE TO RESPOND TO AN OFFICE ACTION