US20090264989A1 - Prosthetic heart valve systems - Google Patents

Prosthetic heart valve systems Download PDF

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Publication number
US20090264989A1
US20090264989A1 US12/380,483 US38048309A US2009264989A1 US 20090264989 A1 US20090264989 A1 US 20090264989A1 US 38048309 A US38048309 A US 38048309A US 2009264989 A1 US2009264989 A1 US 2009264989A1
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United States
Prior art keywords
configuration
heart valve
valve
tubular structure
support
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Abandoned
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US12/380,483
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Philipp Bonhoeffer
Timothy R. Ryan
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Medtronic Inc
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Medtronic Inc
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Priority to US12/380,483 priority Critical patent/US20090264989A1/en
Assigned to MEDTRONIC, INC. reassignment MEDTRONIC, INC. ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: BONHOEFFER, PHILIP, RYAN, TIMOTHY R.
Publication of US20090264989A1 publication Critical patent/US20090264989A1/en
Priority to US13/178,112 priority patent/US8613765B2/en
Priority to US14/097,608 priority patent/US8961593B2/en
Abandoned legal-status Critical Current

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02Prostheses implantable into the body
    • A61F2/24Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body
    • A61F2/2412Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body with soft flexible valve members, e.g. tissue valves shaped like natural valves
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02Prostheses implantable into the body
    • A61F2/24Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body
    • A61F2/2409Support rings therefor, e.g. for connecting valves to tissue
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02Prostheses implantable into the body
    • A61F2/24Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body
    • A61F2/2412Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body with soft flexible valve members, e.g. tissue valves shaped like natural valves
    • A61F2/2418Scaffolds therefor, e.g. support stents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2220/00Fixations or connections for prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2220/0025Connections or couplings between prosthetic parts, e.g. between modular parts; Connecting elements
    • A61F2220/0075Connections or couplings between prosthetic parts, e.g. between modular parts; Connecting elements sutured, ligatured or stitched, retained or tied with a rope, string, thread, wire or cable
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2230/00Geometry of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2230/0063Three-dimensional shapes
    • A61F2230/0073Quadric-shaped
    • A61F2230/0078Quadric-shaped hyperboloidal
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2250/00Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2250/0004Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof adjustable
    • A61F2250/001Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof adjustable for adjusting a diameter
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2250/00Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2250/0014Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof having different values of a given property or geometrical feature, e.g. mechanical property or material property, at different locations within the same prosthesis
    • A61F2250/0039Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof having different values of a given property or geometrical feature, e.g. mechanical property or material property, at different locations within the same prosthesis differing in diameter
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2250/00Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2250/0058Additional features; Implant or prostheses properties not otherwise provided for
    • A61F2250/0071Additional features; Implant or prostheses properties not otherwise provided for breakable or frangible
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2250/00Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2250/0058Additional features; Implant or prostheses properties not otherwise provided for
    • A61F2250/0082Additional features; Implant or prostheses properties not otherwise provided for specially designed for children, e.g. having means for adjusting to their growth

Definitions

  • the present invention relates to prosthetic heart valves. More particularly, it relates to transcatheter implants, methods, and delivery systems.
  • Heart valve replacement surgery involves the replacement of the native valves of the heart with a prosthetic valve.
  • Prosthetic valves include mechanical valves involving only metals and polymers, and tissue valves that include non-synthetic, biocompatible materials such as pericardium, or bovine, equine or porcine tissue.
  • tissue valves that include non-synthetic, biocompatible materials such as pericardium, or bovine, equine or porcine tissue.
  • U.S. Pat. No. 5,383,926 discloses a re-expandable endoprosthesis.
  • the endoprosthesis is said to be re-expandable to accommodate vessel change.
  • U.S. Patent Application Publication Nos. 2003/0199971 A1 (Tower et al.) and 2003/0199963 A1 (Tower et al.) describe a valved segment of bovine jugular vein mounted within an expandable stent, for use as a replacement heart valve.
  • Replacement pulmonary valves may be implanted to replace native pulmonary valves or prosthetic pulmonary valves located in valved conduits as described, for example, in “Percutaneous Insertion of the Pulmonary Valve”, Bonhoeffer, et al., Journal of the American College of Cardiology 2002; 39: 1664-1669.
  • Degenerated and stenotic valves in conduits or in valved stents potentially allow for a second valved stent implantation without the need for surgery, as described, for example, in “Transcatheter Replacement of a Bovine Valve in Pulmonary Position”, Bonhoeffer, et al., Circulation 2000; 102: 813-816.
  • U.S. Patent Application Publication No. 2003/0199971 A1 discloses a stented valve with an ability to be reconfigured after implantation. This is identified as a feature useful in cases where a valve has been implanted in a growing patient (e.g., a child). Rather than replacing a valve periodically during the growth period, the supporting stent may be reconfigured to accommodate growth using a percutaneously introduced balloon catheter for re-engaging the stent to reconfigure the stent so that it will conform to the changes in the implantation site produced by the growth of the patient.
  • valve systems require the removal of an element and its replacement by a different element. It is believed that transcatheter removal of a previously implanted stented valve component creates challenges such as damage to implant site, creation of sites for thrombus/emboli formation and release, paravalvular leakage, inability to access removable elements due to tissue ingrowth and/or complex navigation, and delivery difficulties.
  • the present invention is directed to a heart valve that can be expanded following its implantation in a patient.
  • the expansion can accommodate the growth of a patient and the corresponding growth of the area where the valve is implanted.
  • the present invention may maximize the orifice size of the surgical valve.
  • the present invention includes expandable implantable conduits and expandable bioprosthetic stented valves.
  • the valve may be adapted to accommodate growth of a patient to address limitation on bioprosthetic valve lifespans.
  • the heart valves of the invention may also facilitate a subsequent minimally invasive intervention for replacement of all or part of the valve system.
  • the heart valves of the invention may ease the implantation process and could accommodate the use of a larger valve, which is especially useful for a patient with a small annulus (e.g., a small aortic annulus).
  • the heart valves of the invention have the capacity to overcome concerns regarding conduit longevity and risks associated with performing multiple surgeries in the same area of the patient.
  • the heart valves of the present invention advantageously utilize the proven attributes of surgical valves (e.g., durability), while addressing some of the shortcomings of surgical valves.
  • the heart valves of the invention provide the ability to expand a valve post implant, which provides a number of major advantages that have yet to be proven clinically in humans.
  • surgical tissue valves are typically offered in a limited number of sizes/diameters.
  • the post-implant transcatheter surgical valve expansion provided by the valves of the invention enables the orifice size for each surgical prosthetic valve patient to be maximized post-implant, thereby improving valve function.
  • the post-implant surgical valve transcatheter expansion provided by the valves of the invention enables the orifice for each surgical prosthetic valve pediatric patient to be adjusted post-implant, to thereby accommodate patient growth and eliminate unnecessary surgeries.
  • the post-implant transcatheter surgical valve expansion provided by the valves of the invention increases the orifice size of the surgical prosthetic valve patient to accommodate a larger transcatheter valve after failure of the surgical valve, thereby eliminating the need for surgical replacement.
  • the post-implant transcatheter surgical valve expansion provided by the valves of the invention enables clinicians to implant transcatheter valves inside small bioprosthetic valves with improved hemodynamic results.
  • the post-implant transcatheter surgical valve expansion provided by the valves of the invention may enable implantation of bioprosthetic valves into younger patients by facilitating transcatheter valve replacement once the bioprosthetic valve fails or presents severe risk of failure.
  • the method comprises implanting a surgical valve in an efficient manner.
  • some patients have a small aortic annulus.
  • the present invention affords implantation of a valve in an undersized condition, after which the valve may be expanded to be larger in size or diameter (e.g., with a balloon), such as after the patient grows, minimizing the need for re-operation due to inadequate orifice size.
  • FIG. 1 is a perspective view of an expandable valved conduit in its relatively compressed state, according to one aspect of the invention
  • FIG. 2 is a perspective view of the expandable valved conduit of FIG. 1 in its relatively expanded state, along with a balloon expandable member positioned within the conduit;
  • FIG. 3 is a perspective view of an expandable stent or member or frame for a stented valve in its relatively compressed state, according to another aspect of the invention
  • FIG. 4 is a perspective view of the stent of FIG. 3 assembled to additional components of a valve assembly, with the stent in a first implantable configuration.
  • the fabric covering is removed from the frame of the valve assembly in the area of an expansion joint for illustration purposes;
  • FIG. 5 is a perspective view of the assembly of FIG. 4 with the stent or member or frame expanded from the first implantable configuration to a second implantable configuration;
  • FIG. 6 is a perspective view of the stent or member or frame of FIG. 5 ;
  • FIG. 7 is a perspective view of a balloon expandable member positioned within a valve assembly that is configured as is generally shown in FIGS. 3 and 4 ;
  • FIG. 8 is a perspective view of an expandable component of another embodiment of the invention.
  • FIG. 9 is an enlarged front schematic view of a portion of the expandable component of FIG. 8 ;
  • FIG. 10 is a front schematic view of an embodiment of a heart valve of the invention that is implanted in a first, unexpanded condition
  • FIG. 11 is a front schematic view of a balloon being used to expand the heart valve of FIG. 10 toward an expanded condition
  • FIG. 12 is a front schematic view of the heart valve of FIG. 10 after it has been expanded
  • FIG. 13 is a top view of an expandable tubular component according to another aspect of the invention.
  • FIG. 14 is a side view of a portion of the component of FIG. 13 ;
  • FIG. 15 is an enlarged side view of a portion of FIG. 14 ;
  • FIG. 16 is another embodiment of a side view of an expandable seam of the invention, with the seam in a relatively unexpanded condition;
  • FIG. 17 is a side view of the seam of FIG. 16 in a relatively expanded condition
  • FIG. 18 is a partial cross-sectional view of a seam expansion member of the invention.
  • FIG. 19 is a bottom perspective view of a portion of the expansion member of FIG. 18 ;
  • FIG. 20 is a front view of the expansion member of FIG. 18 ;
  • FIG. 21 is a side view of another embodiment of an expansion member of the invention.
  • FIG. 22 is another side view of the expansion member of FIG. 21 ;
  • FIG. 23 is a front view of another embodiment of an expandable conduit of the invention in a relatively unexpanded state.
  • FIG. 24 is a front view of the conduit of FIG. 23 in a relatively expanded state.
  • FIG. 1 shows an assembly 10 comprising a plurality of circumferential support structures 12 and a valved conduit 14 .
  • the valved conduit 14 may comprise any suitable implantable valve conduit such as those utilizing bovine, equine, human, or porcine tissue, or other materials, such as polymeric and/or metallic materials.
  • the conduit 14 may comprise an outer tubular structure within which multiple leaflets 16 are positioned.
  • the component of the valved conduit may comprise the Medtronic Freestyle (or Contegra) Implantable Valved Conduit, which is commercially available from Medtronic, Inc. of Minneapolis, Minn.
  • a valve having a single leaflet or moveable component is utilized within a valve conduit or other valve structure, including tissue valves or mechanical valves.
  • the support structures 12 may be attached to the outside surface of the outer tubular structure of the valved conduit 14 using conventional means, such as sutures, clips, adhesives, molding, weaving, and the like.
  • the support structures 12 can be attached inside or be positioned within the conduit 14 , such as can be accomplished with a molded elastomer or woven fabric.
  • the support structures 12 described herein can comprise a series of synthetic elements, mesh wires or wire segments. They can be independent or connected to each other via a link that can be permanent or temporary.
  • the support structures 12 may be constructed from a number of suitable biocompatible materials such as polyester, materials such as the membrane “Gore-Tex”, which is commercially available from W.L. Gore & Associates, Inc. of Elkton, Md., stainless steel, titanium, cobalt chromium alloy, platinum iridium, or other natural or man-made materials.
  • Each support structure 12 may be unitary or homologous in composition or could comprise different segments made of different materials.
  • each support structure 12 that allows or provides for its expansion may comprise a different geometry than the remaining portion of that support structure 12 , or it may comprise a more malleable or deflectable portion.
  • Each support structure 12 of a particular assembly 10 may be identical or similar to at least one other support structure 12 of that same assembly 10 , or each support structure 12 of an assembly 10 may be different from the other support structures 12 of the assembly 10 in size, shape, material, and/or other characteristics.
  • all of the support structures 12 are identical in size, shape and composition.
  • the support structures 12 will desirably be designed to provide sufficient support to hold the conduit diameter to a reasonably constant diameter, thereby enabling proper function and durability of the valve.
  • any number of configurations or structures can be used, such as those that can be laser cut, knitted, braided, or woven, for example.
  • the support structures 12 will desirably be able to support the valve for changes in diameter at a minimum number of commissures and inflow regions of the valve. It is further desirable that the support structures are visible or detectable when using common medical imaging techniques, such as fluoroscopy, echocardiography, magnetic resonance imagery, and the like.
  • the elements of the support structures in other embodiments can alternatively be formed from a shape memory material such as nickel titanium alloy (e.g., Nitinol). With this material, the support structure is self-expandable from a contracted state to an expanded state, such as by the application of heat, energy, and the like, or by the removal of external forces (e.g., compressive forces).
  • a shape memory material such as nickel titanium alloy (e.g., Nitinol).
  • the support structures 12 are adapted to be implanted in a patient in the generally cylindrical shape shown in FIG. 1 , although the support structures 12 may instead have an outer shape that is oval, elliptical, irregular, or another shape that is chosen to be appropriate for the location in the patient where it will be implanted.
  • the assembly 10 is configured so that it can be altered at any time after it is initially implanted within a patient. For example, the assembly 10 can be expanded immediately after a procedure of suturing the assembly 10 to the patient's anatomy in order to maximize the size of the orifice in which it is implanted. Alternatively, the assembly 10 could be expanded at some period of time after the initial implantation procedure, such as at the end of the useful life of the tissue of the valved conduit 14 or upon growth of the patient.
  • a first assembly 10 is implanted in a patient using an initial implantation procedure, then after some period of time (e.g., several months or years), a second procedure may be performed to expand the support structures 12 to the configuration of FIG. 2 .
  • This expanded configuration can then receive a second or replacement assembly 10 within its interior structure, if desired.
  • the support structures 12 should be sufficiently strong to withstand the foreseeable stresses that may be encountered at the implantation site after the assembly 10 is implanted without any undesirable degradation that would result in conduit rupture and/or valve failure.
  • the support structure 12 may be designed so that it will deflect in vivo from the configuration shown in FIG. 1 to that shown in FIG. 2 under the influence of a force that can be provided by an expandable assembly 20 , for example.
  • Expandable assembly 20 comprises an expandable balloon member 22 .
  • the balloon member 22 can be a high pressure, non-compliant balloon, such as a Numed Z-Med or Mullins valvuloplasty balloon, for example, although a wide variety of other types and manufacturers of balloons can be used.
  • the balloon member 22 can be sized to produce a desired expansion of the support structure 12 .
  • the balloon member could be provided with various sizes and/or shapes to produce conduits of various sizes and/or shapes.
  • the structure of the balloon member can be capable of expanding by various degrees and/or amounts within a prescribed range in order to provide for proper valve function.
  • the support structures 12 expand by deflection of the portions 11 from the configuration in FIG. 1 , to the configuration 11 ′ in FIG. 2 . In this case, the entire conduit is uniformly expanded via expansion of the assembly 20 .
  • the expandable assembly 20 includes an expansion member that is not a balloon, but is a system having other components that can exert radial forces on the support structures so that they can be expanded to a larger diameter.
  • the expandable assembly may include a self-expanding stent that is capable of being compressed, positioned within the interior area of the support structures, and then released within the support structures.
  • the self-expanding stent is designed so that it can thereby exert sufficient outward radial force when positioned within the support structures to diametrically deform and/or expand the support structures, in accordance with the various embodiments of the invention.
  • Conduit 30 includes a central area 32 that is at least slightly smaller in diameter than the end portions 34 , 35 when the conduit is initially implanted. This central area 32 is the portion of conduit 30 in which valve leaflets can be positioned. Expandable support structures 36 are longitudinally spaced from each other in the central area 32 , where the structures 36 are in their relatively expanded condition in FIG. 23 and in their relatively expanded condition in FIG. 24 .
  • An expansion mechanism e.g., balloon
  • FIGS. 3 through 7 disclose an expandable support structure component 42 of the invention, as positioned relative to a stent or valve structure 40 .
  • Valve structure 40 includes a sewing ring 46 attached to three stent posts or commissural members 45 . It is noted that this structure would be provided for a tricuspid valve, but that only two of such commissural members would be provided for a bicuspid valve, in another embodiment. All or a portion of the valve structure 40 , including the sewing ring 46 and commissural members 45 , can be covered by a flexible covering, which may be a tissue, polymer, fabric, metal, or cloth material to which leaflets (not shown) of the heart valve can be sewn. Further, as is known in the art, the internal structure of each of the commissural members 45 can be formed of a stiff but resiliently bendable material. This construction allows the commissural members 45 to be deflected by the application of an external or internal radial force.
  • the valve structure 40 is generally tubular in shape, defining an internal area that extends from an inflow end to an outflow end.
  • the shape of the valve structure can be oval, elliptical, irregular, or any other desired shape.
  • the internal area is essentially composed of the valve structure 40 , and the valve structure 40 selectively allows for fluid flow into or out of the lumen of the natural heart valve in which it is implanted.
  • the internal area is alternatively open and closed to the lumen of the natural heart valve in which it is inserted via movement of leaflets.
  • leaflets associated with valve structure 40 are not shown in FIGS. 4 and 5 .
  • the prosthetic heart valves used in accordance with the devices and methods of the invention may include a wide variety of different configurations, such as a prosthetic heart valve having one or more tissue leaflets, a synthetic heart valve having polymeric leaflets, or a mechanical valve, and can be specifically configured for replacing any heart valve. That is, the prosthetic heart valves of the invention can generally be used for replacement of aortic, mitral, tricuspid, or pulmonic valves, for use as a venous valve, or to replace a failed bioprosthesis, such as in the area of an aortic valve or mitral valve, for example.
  • the replacement prosthetic heart valves of the invention can be employed to functionally replace stentless bioprosthetic heart valves as well.
  • the support structure 42 is part of the valve structure 40 and includes portions that generally follow the shape of the stent posts 45 .
  • Arch or member 44 of the support structure 42 can be deformed or modified after the valve structure 40 has been implanted to effectively enlarge the size of the orifice of the valve structure 40 .
  • the support structure 42 may comprise the shape shown in FIGS. 3-4 and 7 .
  • the shape of the support structure 42 can be modified such that member 44 shown in FIGS. 3 and 4 assumes the shape shown as member 44 ′ in FIGS. 5 and 6 .
  • the internal area or diameter of the support structure 42 will be larger in order to provide the maximum available orifice area based on the patient's anatomy.
  • expansion of the support structure 42 can put the valve structure in closer contact with the vessel anatomy, thereby improving the paravalvular seal, which can thereby reduce the degree of paravalvular leakage.
  • Expansion of the support structure can also improve the stability of the surgical valve implant, which can reduce the chances for dehiscence.
  • an intermediate deformation of the member 44 can also occur so that the internal area has a size that is between that shown in FIGS. 4 and 5 .
  • the shape of member 44 shown in FIGS. 3-7 are not intended to be limiting. Any suitable shapes or mechanisms may be utilized that allow for expansion of the valve support structure 42 , such as sinusoidal, accordion, triangular or any combination of segments and/or arcuate shapes.
  • the gap in the sewing ring 46 shown in FIGS. 4 , 5 , and 7 is provided in the Figures for illustrative purposes. Such a gap would not typically be provided, although it is contemplated that such sewing ring 46 does include such a gap.
  • cloth or another material that is used to cover the rest of the sewing ring 46 would preferably span such a gap to provide a continuous cover around the perimeter of the sewing ring 46 . In this way, the paravalvular seal can be maintained more easily once the device is implanted in a patient.
  • This material may be stretchable or otherwise deformable to allow for expansion of the overall size of the valve, if desired.
  • the sewing ring 46 does not include a gap, the ring 46 can be expandable or deformable, such as can be accomplished with a deformable material (e.g., stretchable portions) and/or with one or more expandable portions.
  • FIG. 3 further illustrates an optional restraining element 48 that is positioned around a portion of one of the members 44 .
  • support structure 42 can be a self-expanding component, where element 48 is positioned in such a way that it maintains the member 44 in an initial or unexpanded condition.
  • the restraining element 48 can later be removed, deformed, or broken in order to allow the member 44 to deform or straighten, thereby allowing overall support structure 42 to expand to a larger diameter.
  • One or more restraining elements 48 can be positioned relative to some or all of the members 44 , wherein if more than one restraining element is used, the number of elements 48 that are deformed or removed can be chosen to allow the desired amount of expansion of the support structure 42 . That is, only one element 48 may be removed in a first procedure to allow a first amount of expansion of the support structure 42 , and then one or more additional elements 48 can be removed in one or more subsequent procedures to allow additional expansion of the support structure 42 .
  • valve support structure can also be composed of multiple elements that function together in a similar manner as a single valve support structure of the type previously described.
  • the valve support structure may include an outer tubular structural piece having a central opening into which a connector can be positioned.
  • a connector can be slideable relative to the outer tubular structural piece to allow for expansion of the outer periphery of the support structure.
  • tracks or rails can be used to allow for enlargement or expansion of the outer perimeter of the support structure.
  • FIG. 7 A portion of a post-implant expansion system 50 is illustrated in FIG. 7 , which comprises an expandable member 52 (e.g., a balloon that can be made of nylon, polyurethane, polyethylene, or polyethylene terephthalate (PET)).
  • the system 50 may be utilized to modify the valve structure 40 from its first, unexpanded or partially expanded position to its second, expanded or partially expanded position.
  • the assembly 10 and valve structure 40 When the assembly 10 and valve structure 40 are in their second, expanded positions or configurations, they may be configured to receive a replacement transcatheter valve assembly.
  • a replacement valve conduit may be placed between the balloon 22 and the inside of the expandable conduit 14 in FIG. 2 .
  • the assembly 10 is enlarged to its expanded condition and a replacement valve can be subsequently or simultaneously implanted therein.
  • the native or existing valve can serve as a landing zone for a new heart valve implant. It is also possible to first expand the valve structure and to later insert a replacement transcatheter valve, where this can be performed either a relatively short time or a relatively long time after that expansion is performed.
  • FIGS. 8 and 9 illustrate another conduit configuration that can be used with certain aspects of the invention.
  • a conduit 60 is illustrated in FIG. 8 , which may comprise a specially designed expandable structure 62 .
  • This conduit 60 may or may not include a valve, depending on the application.
  • the structure 62 comprises a mesh or woven type of material configuration (e.g., a biocompatible polymer, metal, or combination thereof).
  • the expandable structure 62 may comprise multiple members 66 disposed between adjacent elongated member 68 , shown in FIG. 9 , which can withstand stresses and tension during expected use of the heart valve assembly.
  • the members 66 are designed to permanently deform, stretch, and/or break under the applied load of an expandable balloon member (not shown in FIGS.
  • members 66 may be fabric fibers, wires, or polymer elements, for example, which can break or stretch when placed under stress. If the members 66 stretch, such a stretching will preferably cause permanent or semi-permanent deformation of the members 66 so that they do not contract all the way back to their original size once the stress or load is removed.
  • Members 64 are longer than members 66 and are curved or bent when the conduit 60 is in its relatively unexpanded condition. In addition, members 64 are more robust and are designed to withstand more stress than members 66 .
  • Members 66 can be differently configured at various portions of the conduit (e.g., inflow, outflow, etc.) to allow various shapes upon application of loads.
  • FIGS. 10-12 schematically illustrate a surgical method according to the invention.
  • FIG. 10 shows an aortic annulus 102 , which may be relatively small, either due to the patient's natural anatomy or excessive calcification.
  • An implantable valve 100 according to the invention is implanted in the patient's vasculature 104 (e.g., encompassing the native valve or occupying the position of a removed valve).
  • a sizing balloon or surgical valve sizer can be utilized to identify a desired maximum size of the valve 100 .
  • FIG. 11 shows the use of a balloon 110 to expand the valve 100 to a larger circumference, which can be performed at any time after the initial valve implantation.
  • FIG. 12 shows the valve 100 ′ after it has been enlarged to an expanded condition. In this manner, the present invention can be utilized to maximize the effective valve orifice for a particular patient following the initial implantation procedure.
  • an expandable bioprosthetic valve may be implanted in the patient in an unexpanded, yet functional condition. That valve may be used until the useful life of its components reach an endpoint or the patient outgrows it.
  • an expandable member may then be utilized to modify or enlarge the valve to its expanded condition, and then a replacement transcatheter valve (which may itself be expandable) may be implanted with the first bioprosthetic valve. In this way, larger orifice areas following transcatheter valve procedures may be available than would be available with conventional surgical valves.
  • FIGS. 13-15 illustrate another embodiment of a component 200 of the invention.
  • the component 200 comprises a tubular conduit 204 with at least two releasable seams 202 , although it is possible that component 200 comprises more or less than two seams.
  • the releasable seams 202 are positioned to essentially create a loop 206 of material from a tubular structure, where the seam 202 is sewn or otherwise secured (e.g., clips, sutures, and the like) along a seam line.
  • the conduit 204 can be loaded radially, thereby breaking, deforming, stretching, or otherwise releasing material of the seams 202 (i.e., the loop 206 ) and allowing the component 200 to expand.
  • the seam 202 may be created with a series of breakable or stretchable fibers (e.g., fabric fibers, wires, or polymeric elements), or discrete deformable elements 205 that can be broken or deformed by the application of a radial force, such as by a balloon expandable member.
  • the loop 206 is shown on the exterior of the component 200 in FIG. 13 , it may alternatively be placed within the interior area of the component 200 .
  • FIGS. 16 and 17 illustrate a portion of another embodiment of a seam of a tubular conduit, which includes a series of discrete deformable elements 207 , one of which is illustrated in these figures.
  • Element 207 is shown in its unexpanded condition in FIG. 16 as having a diameter or dimension d 1 , then in its expanded condition in FIG. 17 as having a diameter or dimension d 2 .
  • Diameter d 1 is at least somewhat smaller than the diameter d 2 , which thereby illustrates the expansion in the seam area of the conduit.
  • This deformation of the element 207 is preferably permanent or semi-permanent after the force that was used to deform the element is removed.
  • FIGS. 21 and 22 illustrate another deformable element 214 .
  • Element 214 is shown in its unexpanded condition in FIG. 21 as having a width or length d 1 , then in its expanded condition in FIG. 22 as having a width or length d 2 .
  • Dimension d 1 is smaller than the dimension d 2 , which again illustrates the expansion of the seam area of the conduit.
  • FIGS. 18-20 illustrate a portion of another embodiment of a loop 206 of a conduit seam, and further including a deformable element 208 .
  • Deformable element 208 includes lobes 212 and a bar 210 extending from each lobe 212 .
  • the lobes 212 are spaced from each other around the element 208 .
  • material of the conduit 204 is looped relative to the bars 210 to create the loop of a seam.
  • Application of radial force such as the expansion of an internally positioned balloon, can deform the element 208 , thereby allowing expansion of the seam.

Abstract

A heart valve that can be expanded following its implantation in a patient, such as to accommodate the growth of a patient and the corresponding growth of the area where the valve is implanted, and to minimize paravalvular leakage. In one aspect, the invention may maximize the orifice size of the surgical valve. The invention includes expandable implantable conduits and expandable bioprosthetic stented valves. In one aspect of the invention, the valve may be adapted to accommodate growth of a patient to address limitation on bioprosthetic valve lifespans.

Description

    CROSS-REFERENCE TO RELATED APPLICATION
  • The present application claims priority to U.S. Provisional Application No. 61/032,185, filed Feb. 28, 2008, and titled “Prosthetic Heart Valve Systems,” the entire contents of which is incorporated herein by reference in its entirety.
  • TECHNICAL FIELD
  • The present invention relates to prosthetic heart valves. More particularly, it relates to transcatheter implants, methods, and delivery systems.
  • BACKGROUND
  • Heart valve replacement surgery involves the replacement of the native valves of the heart with a prosthetic valve. Prosthetic valves include mechanical valves involving only metals and polymers, and tissue valves that include non-synthetic, biocompatible materials such as pericardium, or bovine, equine or porcine tissue. Some patients have a relatively small aortic root due to their particular anatomy or excessive calcification. Some patients (e.g., young children) are likely to outgrow a prosthetic valve or outlive the useful life of a prosthetic valve.
  • U.S. Pat. No. 5,383,926 (Lock et al.) discloses a re-expandable endoprosthesis. The endoprosthesis is said to be re-expandable to accommodate vessel change.
  • U.S. Patent Application Publication Nos. 2003/0199971 A1 (Tower et al.) and 2003/0199963 A1 (Tower et al.) describe a valved segment of bovine jugular vein mounted within an expandable stent, for use as a replacement heart valve. Replacement pulmonary valves may be implanted to replace native pulmonary valves or prosthetic pulmonary valves located in valved conduits as described, for example, in “Percutaneous Insertion of the Pulmonary Valve”, Bonhoeffer, et al., Journal of the American College of Cardiology 2002; 39: 1664-1669.
  • Degenerated and stenotic valves in conduits or in valved stents potentially allow for a second valved stent implantation without the need for surgery, as described, for example, in “Transcatheter Replacement of a Bovine Valve in Pulmonary Position”, Bonhoeffer, et al., Circulation 2000; 102: 813-816. It has been proposed that sequential percutaneous pulmonary valve implantation is feasible and theoretically could delay the need for invasive surgery indefinitely, thus overcoming concerns regarding conduit longevity and risks associated with reoperation, as described, for example, in “The potential impact of percutaneous pulmonary valve stent implantation on right ventricular outflow tract re-intervention”, Coates, et al., European Journal of Cardio-thoracic Surgery 27 (2005) 536-543.
  • U.S. Patent Application Publication No. 2003/0199971 A1 (Tower et al.) discloses a stented valve with an ability to be reconfigured after implantation. This is identified as a feature useful in cases where a valve has been implanted in a growing patient (e.g., a child). Rather than replacing a valve periodically during the growth period, the supporting stent may be reconfigured to accommodate growth using a percutaneously introduced balloon catheter for re-engaging the stent to reconfigure the stent so that it will conform to the changes in the implantation site produced by the growth of the patient. In an article by Bonhoeffer, et al. entitled “Percutaneous Insertion of the Pulmonary Valve” J Am Coll Cardiol, 2002; 39:1664-1669, the percutaneous delivery of a biological valve is described. The valve is sutured to an expandable stent within a previously implanted valved or non-valved conduit, or a previously implanted valve. Again, radial expansion of the secondary valve stent is used for placing an maintaining the replacement valve.
  • Stented valve systems involving two or more components are disclosed in U.S. Patent Application Nos. 2004/0030381 A1 (Shu et al.) and 2008/0004696 A1 (Vesely et al.); U.S. Pat. Nos. 6,530,052 (Khou et al.) and 7,011,681 (Vesely et al.) and PCT Publication Nos. WO 06/0127756 A2 (Rowe et al.), WO 07/018,1820 (Nugent et al.) and WO 07/130,537 (Lock et al.). Some of these valve systems describe the reuse of a portion of their system. Some of these valve systems require the removal of an element and its replacement by a different element. It is believed that transcatheter removal of a previously implanted stented valve component creates challenges such as damage to implant site, creation of sites for thrombus/emboli formation and release, paravalvular leakage, inability to access removable elements due to tissue ingrowth and/or complex navigation, and delivery difficulties.
  • SUMMARY
  • The present invention is directed to a heart valve that can be expanded following its implantation in a patient. In one aspect of the present invention, the expansion can accommodate the growth of a patient and the corresponding growth of the area where the valve is implanted. In another aspect, the present invention may maximize the orifice size of the surgical valve. The present invention includes expandable implantable conduits and expandable bioprosthetic stented valves. In one aspect of the invention, the valve may be adapted to accommodate growth of a patient to address limitation on bioprosthetic valve lifespans.
  • The heart valves of the invention may also facilitate a subsequent minimally invasive intervention for replacement of all or part of the valve system. In another aspect, the heart valves of the invention may ease the implantation process and could accommodate the use of a larger valve, which is especially useful for a patient with a small annulus (e.g., a small aortic annulus).
  • The heart valves of the invention have the capacity to overcome concerns regarding conduit longevity and risks associated with performing multiple surgeries in the same area of the patient. The heart valves of the present invention advantageously utilize the proven attributes of surgical valves (e.g., durability), while addressing some of the shortcomings of surgical valves. In particular, the heart valves of the invention provide the ability to expand a valve post implant, which provides a number of major advantages that have yet to be proven clinically in humans. First, surgical tissue valves are typically offered in a limited number of sizes/diameters. The post-implant transcatheter surgical valve expansion provided by the valves of the invention enables the orifice size for each surgical prosthetic valve patient to be maximized post-implant, thereby improving valve function. Second, the post-implant surgical valve transcatheter expansion provided by the valves of the invention enables the orifice for each surgical prosthetic valve pediatric patient to be adjusted post-implant, to thereby accommodate patient growth and eliminate unnecessary surgeries. Third, the post-implant transcatheter surgical valve expansion provided by the valves of the invention increases the orifice size of the surgical prosthetic valve patient to accommodate a larger transcatheter valve after failure of the surgical valve, thereby eliminating the need for surgical replacement. Fourth, the post-implant transcatheter surgical valve expansion provided by the valves of the invention enables clinicians to implant transcatheter valves inside small bioprosthetic valves with improved hemodynamic results. Fifth, the post-implant transcatheter surgical valve expansion provided by the valves of the invention may enable implantation of bioprosthetic valves into younger patients by facilitating transcatheter valve replacement once the bioprosthetic valve fails or presents severe risk of failure.
  • In another aspect of the invention, surgical methods are provided. In one embodiment, the method comprises implanting a surgical valve in an efficient manner. For example, some patients have a small aortic annulus. The present invention affords implantation of a valve in an undersized condition, after which the valve may be expanded to be larger in size or diameter (e.g., with a balloon), such as after the patient grows, minimizing the need for re-operation due to inadequate orifice size.
  • BRIEF DESCRIPTION OF THE DRAWINGS
  • The present invention will be further explained with reference to the appended Figures, wherein like structure is referred to by like numerals throughout the several views, and wherein:
  • FIG. 1 is a perspective view of an expandable valved conduit in its relatively compressed state, according to one aspect of the invention;
  • FIG. 2 is a perspective view of the expandable valved conduit of FIG. 1 in its relatively expanded state, along with a balloon expandable member positioned within the conduit;
  • FIG. 3 is a perspective view of an expandable stent or member or frame for a stented valve in its relatively compressed state, according to another aspect of the invention;
  • FIG. 4 is a perspective view of the stent of FIG. 3 assembled to additional components of a valve assembly, with the stent in a first implantable configuration. The fabric covering is removed from the frame of the valve assembly in the area of an expansion joint for illustration purposes;
  • FIG. 5 is a perspective view of the assembly of FIG. 4 with the stent or member or frame expanded from the first implantable configuration to a second implantable configuration;
  • FIG. 6 is a perspective view of the stent or member or frame of FIG. 5;
  • FIG. 7 is a perspective view of a balloon expandable member positioned within a valve assembly that is configured as is generally shown in FIGS. 3 and 4;
  • FIG. 8 is a perspective view of an expandable component of another embodiment of the invention;
  • FIG. 9 is an enlarged front schematic view of a portion of the expandable component of FIG. 8;
  • FIG. 10 is a front schematic view of an embodiment of a heart valve of the invention that is implanted in a first, unexpanded condition;
  • FIG. 11 is a front schematic view of a balloon being used to expand the heart valve of FIG. 10 toward an expanded condition;
  • FIG. 12 is a front schematic view of the heart valve of FIG. 10 after it has been expanded;
  • FIG. 13 is a top view of an expandable tubular component according to another aspect of the invention;
  • FIG. 14 is a side view of a portion of the component of FIG. 13;
  • FIG. 15 is an enlarged side view of a portion of FIG. 14;
  • FIG. 16 is another embodiment of a side view of an expandable seam of the invention, with the seam in a relatively unexpanded condition;
  • FIG. 17 is a side view of the seam of FIG. 16 in a relatively expanded condition;
  • FIG. 18 is a partial cross-sectional view of a seam expansion member of the invention;
  • FIG. 19 is a bottom perspective view of a portion of the expansion member of FIG. 18;
  • FIG. 20 is a front view of the expansion member of FIG. 18;
  • FIG. 21 is a side view of another embodiment of an expansion member of the invention;
  • FIG. 22 is another side view of the expansion member of FIG. 21;
  • FIG. 23 is a front view of another embodiment of an expandable conduit of the invention in a relatively unexpanded state; and
  • FIG. 24 is a front view of the conduit of FIG. 23 in a relatively expanded state.
  • DETAILED DESCRIPTION
  • FIG. 1 shows an assembly 10 comprising a plurality of circumferential support structures 12 and a valved conduit 14. The valved conduit 14 may comprise any suitable implantable valve conduit such as those utilizing bovine, equine, human, or porcine tissue, or other materials, such as polymeric and/or metallic materials. The conduit 14 may comprise an outer tubular structure within which multiple leaflets 16 are positioned. For example, the component of the valved conduit may comprise the Medtronic Freestyle (or Contegra) Implantable Valved Conduit, which is commercially available from Medtronic, Inc. of Minneapolis, Minn. However, it is also possible with the various embodiments of the invention that a valve having a single leaflet or moveable component is utilized within a valve conduit or other valve structure, including tissue valves or mechanical valves.
  • The support structures 12 may be attached to the outside surface of the outer tubular structure of the valved conduit 14 using conventional means, such as sutures, clips, adhesives, molding, weaving, and the like. Alternatively, the support structures 12 can be attached inside or be positioned within the conduit 14, such as can be accomplished with a molded elastomer or woven fabric.
  • The support structures 12 described herein can comprise a series of synthetic elements, mesh wires or wire segments. They can be independent or connected to each other via a link that can be permanent or temporary. The support structures 12 may be constructed from a number of suitable biocompatible materials such as polyester, materials such as the membrane “Gore-Tex”, which is commercially available from W.L. Gore & Associates, Inc. of Elkton, Md., stainless steel, titanium, cobalt chromium alloy, platinum iridium, or other natural or man-made materials. Each support structure 12 may be unitary or homologous in composition or could comprise different segments made of different materials. The portion of each support structure 12 that allows or provides for its expansion may comprise a different geometry than the remaining portion of that support structure 12, or it may comprise a more malleable or deflectable portion. Each support structure 12 of a particular assembly 10 may be identical or similar to at least one other support structure 12 of that same assembly 10, or each support structure 12 of an assembly 10 may be different from the other support structures 12 of the assembly 10 in size, shape, material, and/or other characteristics. In one embodiment of an assembly 10 of the invention, all of the support structures 12 are identical in size, shape and composition. The support structures 12 will desirably be designed to provide sufficient support to hold the conduit diameter to a reasonably constant diameter, thereby enabling proper function and durability of the valve. Any number of configurations or structures can be used, such as those that can be laser cut, knitted, braided, or woven, for example. In addition, the support structures 12 will desirably be able to support the valve for changes in diameter at a minimum number of commissures and inflow regions of the valve. It is further desirable that the support structures are visible or detectable when using common medical imaging techniques, such as fluoroscopy, echocardiography, magnetic resonance imagery, and the like.
  • The elements of the support structures in other embodiments can alternatively be formed from a shape memory material such as nickel titanium alloy (e.g., Nitinol). With this material, the support structure is self-expandable from a contracted state to an expanded state, such as by the application of heat, energy, and the like, or by the removal of external forces (e.g., compressive forces).
  • The support structures 12 are adapted to be implanted in a patient in the generally cylindrical shape shown in FIG. 1, although the support structures 12 may instead have an outer shape that is oval, elliptical, irregular, or another shape that is chosen to be appropriate for the location in the patient where it will be implanted. The assembly 10 is configured so that it can be altered at any time after it is initially implanted within a patient. For example, the assembly 10 can be expanded immediately after a procedure of suturing the assembly 10 to the patient's anatomy in order to maximize the size of the orifice in which it is implanted. Alternatively, the assembly 10 could be expanded at some period of time after the initial implantation procedure, such as at the end of the useful life of the tissue of the valved conduit 14 or upon growth of the patient. In another embodiment, a first assembly 10 is implanted in a patient using an initial implantation procedure, then after some period of time (e.g., several months or years), a second procedure may be performed to expand the support structures 12 to the configuration of FIG. 2. This expanded configuration can then receive a second or replacement assembly 10 within its interior structure, if desired.
  • In one embodiment, the support structures 12 should be sufficiently strong to withstand the foreseeable stresses that may be encountered at the implantation site after the assembly 10 is implanted without any undesirable degradation that would result in conduit rupture and/or valve failure. However, the support structure 12 may be designed so that it will deflect in vivo from the configuration shown in FIG. 1 to that shown in FIG. 2 under the influence of a force that can be provided by an expandable assembly 20, for example. Expandable assembly 20 comprises an expandable balloon member 22. The balloon member 22 can be a high pressure, non-compliant balloon, such as a Numed Z-Med or Mullins valvuloplasty balloon, for example, although a wide variety of other types and manufacturers of balloons can be used. The balloon member 22 can be sized to produce a desired expansion of the support structure 12. The balloon member could be provided with various sizes and/or shapes to produce conduits of various sizes and/or shapes. The structure of the balloon member can be capable of expanding by various degrees and/or amounts within a prescribed range in order to provide for proper valve function. In one embodiment of the invention, the support structures 12 expand by deflection of the portions 11 from the configuration in FIG. 1, to the configuration 11′ in FIG. 2. In this case, the entire conduit is uniformly expanded via expansion of the assembly 20.
  • In another embodiment, the expandable assembly 20 includes an expansion member that is not a balloon, but is a system having other components that can exert radial forces on the support structures so that they can be expanded to a larger diameter. For example, the expandable assembly may include a self-expanding stent that is capable of being compressed, positioned within the interior area of the support structures, and then released within the support structures. The self-expanding stent is designed so that it can thereby exert sufficient outward radial force when positioned within the support structures to diametrically deform and/or expand the support structures, in accordance with the various embodiments of the invention.
  • An alternative embodiment of a conduit 30 is illustrated in FIGS. 23 and 24. Conduit 30 includes a central area 32 that is at least slightly smaller in diameter than the end portions 34, 35 when the conduit is initially implanted. This central area 32 is the portion of conduit 30 in which valve leaflets can be positioned. Expandable support structures 36 are longitudinally spaced from each other in the central area 32, where the structures 36 are in their relatively expanded condition in FIG. 23 and in their relatively expanded condition in FIG. 24. An expansion mechanism (e.g., balloon) can be used to expand the central area 32 to a diameter that is closer to that of the end portions 34, 35, thereby making the conduit 30 more cylindrical in shape.
  • FIGS. 3 through 7 disclose an expandable support structure component 42 of the invention, as positioned relative to a stent or valve structure 40. Valve structure 40 includes a sewing ring 46 attached to three stent posts or commissural members 45. It is noted that this structure would be provided for a tricuspid valve, but that only two of such commissural members would be provided for a bicuspid valve, in another embodiment. All or a portion of the valve structure 40, including the sewing ring 46 and commissural members 45, can be covered by a flexible covering, which may be a tissue, polymer, fabric, metal, or cloth material to which leaflets (not shown) of the heart valve can be sewn. Further, as is known in the art, the internal structure of each of the commissural members 45 can be formed of a stiff but resiliently bendable material. This construction allows the commissural members 45 to be deflected by the application of an external or internal radial force.
  • The valve structure 40 is generally tubular in shape, defining an internal area that extends from an inflow end to an outflow end. Alternatively, the shape of the valve structure can be oval, elliptical, irregular, or any other desired shape. The internal area is essentially composed of the valve structure 40, and the valve structure 40 selectively allows for fluid flow into or out of the lumen of the natural heart valve in which it is implanted. Thus, the internal area is alternatively open and closed to the lumen of the natural heart valve in which it is inserted via movement of leaflets. For ease of illustration, leaflets associated with valve structure 40 are not shown in FIGS. 4 and 5.
  • As referred to herein, the prosthetic heart valves (e.g., valves that utilize a valve structure 40) used in accordance with the devices and methods of the invention may include a wide variety of different configurations, such as a prosthetic heart valve having one or more tissue leaflets, a synthetic heart valve having polymeric leaflets, or a mechanical valve, and can be specifically configured for replacing any heart valve. That is, the prosthetic heart valves of the invention can generally be used for replacement of aortic, mitral, tricuspid, or pulmonic valves, for use as a venous valve, or to replace a failed bioprosthesis, such as in the area of an aortic valve or mitral valve, for example. The replacement prosthetic heart valves of the invention can be employed to functionally replace stentless bioprosthetic heart valves as well.
  • The support structure 42 is part of the valve structure 40 and includes portions that generally follow the shape of the stent posts 45. Arch or member 44 of the support structure 42 can be deformed or modified after the valve structure 40 has been implanted to effectively enlarge the size of the orifice of the valve structure 40. In an initial implanted configuration, the support structure 42 may comprise the shape shown in FIGS. 3-4 and 7. In a subsequent procedure (which could potentially be any period of time later, such as minutes, hours, days, months or years), the shape of the support structure 42 can be modified such that member 44 shown in FIGS. 3 and 4 assumes the shape shown as member 44′ in FIGS. 5 and 6. In this way, the internal area or diameter of the support structure 42 will be larger in order to provide the maximum available orifice area based on the patient's anatomy. In addition, expansion of the support structure 42 can put the valve structure in closer contact with the vessel anatomy, thereby improving the paravalvular seal, which can thereby reduce the degree of paravalvular leakage. Expansion of the support structure can also improve the stability of the surgical valve implant, which can reduce the chances for dehiscence. It is contemplated that an intermediate deformation of the member 44 can also occur so that the internal area has a size that is between that shown in FIGS. 4 and 5. It should be noted that the shape of member 44 shown in FIGS. 3-7 are not intended to be limiting. Any suitable shapes or mechanisms may be utilized that allow for expansion of the valve support structure 42, such as sinusoidal, accordion, triangular or any combination of segments and/or arcuate shapes.
  • It is noted that the gap in the sewing ring 46 shown in FIGS. 4, 5, and 7, for example, is provided in the Figures for illustrative purposes. Such a gap would not typically be provided, although it is contemplated that such sewing ring 46 does include such a gap. When the base portion of the sewing ring 46 includes such a gap, cloth or another material that is used to cover the rest of the sewing ring 46 would preferably span such a gap to provide a continuous cover around the perimeter of the sewing ring 46. In this way, the paravalvular seal can be maintained more easily once the device is implanted in a patient. This material may be stretchable or otherwise deformable to allow for expansion of the overall size of the valve, if desired. If the sewing ring 46 does not include a gap, the ring 46 can be expandable or deformable, such as can be accomplished with a deformable material (e.g., stretchable portions) and/or with one or more expandable portions.
  • FIG. 3 further illustrates an optional restraining element 48 that is positioned around a portion of one of the members 44. In this embodiment, support structure 42 can be a self-expanding component, where element 48 is positioned in such a way that it maintains the member 44 in an initial or unexpanded condition. The restraining element 48 can later be removed, deformed, or broken in order to allow the member 44 to deform or straighten, thereby allowing overall support structure 42 to expand to a larger diameter. One or more restraining elements 48 can be positioned relative to some or all of the members 44, wherein if more than one restraining element is used, the number of elements 48 that are deformed or removed can be chosen to allow the desired amount of expansion of the support structure 42. That is, only one element 48 may be removed in a first procedure to allow a first amount of expansion of the support structure 42, and then one or more additional elements 48 can be removed in one or more subsequent procedures to allow additional expansion of the support structure 42.
  • The valve support structure can also be composed of multiple elements that function together in a similar manner as a single valve support structure of the type previously described. For one example, the valve support structure may include an outer tubular structural piece having a central opening into which a connector can be positioned. Such a connector can be slideable relative to the outer tubular structural piece to allow for expansion of the outer periphery of the support structure. In another embodiment, tracks or rails can be used to allow for enlargement or expansion of the outer perimeter of the support structure.
  • A portion of a post-implant expansion system 50 is illustrated in FIG. 7, which comprises an expandable member 52 (e.g., a balloon that can be made of nylon, polyurethane, polyethylene, or polyethylene terephthalate (PET)). The system 50 may be utilized to modify the valve structure 40 from its first, unexpanded or partially expanded position to its second, expanded or partially expanded position. When the assembly 10 and valve structure 40 are in their second, expanded positions or configurations, they may be configured to receive a replacement transcatheter valve assembly. For example, a replacement valve conduit may be placed between the balloon 22 and the inside of the expandable conduit 14 in FIG. 2. In this embodiment, the assembly 10 is enlarged to its expanded condition and a replacement valve can be subsequently or simultaneously implanted therein. The native or existing valve can serve as a landing zone for a new heart valve implant. It is also possible to first expand the valve structure and to later insert a replacement transcatheter valve, where this can be performed either a relatively short time or a relatively long time after that expansion is performed.
  • FIGS. 8 and 9 illustrate another conduit configuration that can be used with certain aspects of the invention. In particular, a conduit 60 is illustrated in FIG. 8, which may comprise a specially designed expandable structure 62. This conduit 60 may or may not include a valve, depending on the application. In the depicted embodiment, the structure 62 comprises a mesh or woven type of material configuration (e.g., a biocompatible polymer, metal, or combination thereof). The expandable structure 62 may comprise multiple members 66 disposed between adjacent elongated member 68, shown in FIG. 9, which can withstand stresses and tension during expected use of the heart valve assembly. However, the members 66 are designed to permanently deform, stretch, and/or break under the applied load of an expandable balloon member (not shown in FIGS. 8 and 9) or another device that imparts radial force. These members 66 may be fabric fibers, wires, or polymer elements, for example, which can break or stretch when placed under stress. If the members 66 stretch, such a stretching will preferably cause permanent or semi-permanent deformation of the members 66 so that they do not contract all the way back to their original size once the stress or load is removed. Members 64 are longer than members 66 and are curved or bent when the conduit 60 is in its relatively unexpanded condition. In addition, members 64 are more robust and are designed to withstand more stress than members 66. As a result, when a balloon or other expandable member is placed within the structure 62 and expanded, the members 66 will break or stretch and the members 64 will become straighter, thereby affording expansion of the expandable conduit 60. Members 66 can be differently configured at various portions of the conduit (e.g., inflow, outflow, etc.) to allow various shapes upon application of loads.
  • FIGS. 10-12 schematically illustrate a surgical method according to the invention. Specifically, FIG. 10 shows an aortic annulus 102, which may be relatively small, either due to the patient's natural anatomy or excessive calcification. An implantable valve 100 according to the invention is implanted in the patient's vasculature 104 (e.g., encompassing the native valve or occupying the position of a removed valve). Prior to this step, a sizing balloon or surgical valve sizer can be utilized to identify a desired maximum size of the valve 100.
  • A valve can be relative easily sewn into the patient's anatomy in the condition illustrated in FIG. 10. FIG. 11 then shows the use of a balloon 110 to expand the valve 100 to a larger circumference, which can be performed at any time after the initial valve implantation. FIG. 12 shows the valve 100′ after it has been enlarged to an expanded condition. In this manner, the present invention can be utilized to maximize the effective valve orifice for a particular patient following the initial implantation procedure.
  • In another surgical embodiment, an expandable bioprosthetic valve may be implanted in the patient in an unexpanded, yet functional condition. That valve may be used until the useful life of its components reach an endpoint or the patient outgrows it. In this embodiment, an expandable member may then be utilized to modify or enlarge the valve to its expanded condition, and then a replacement transcatheter valve (which may itself be expandable) may be implanted with the first bioprosthetic valve. In this way, larger orifice areas following transcatheter valve procedures may be available than would be available with conventional surgical valves.
  • FIGS. 13-15 illustrate another embodiment of a component 200 of the invention. The component 200 comprises a tubular conduit 204 with at least two releasable seams 202, although it is possible that component 200 comprises more or less than two seams. The releasable seams 202 are positioned to essentially create a loop 206 of material from a tubular structure, where the seam 202 is sewn or otherwise secured (e.g., clips, sutures, and the like) along a seam line. When desired, the conduit 204 can be loaded radially, thereby breaking, deforming, stretching, or otherwise releasing material of the seams 202 (i.e., the loop 206) and allowing the component 200 to expand. That is, all or most of the material that makes up the loop 206 will be exposed to the inner area of the conduit 204 after expansion of the component 200. As shown in FIG. 15, the seam 202 may be created with a series of breakable or stretchable fibers (e.g., fabric fibers, wires, or polymeric elements), or discrete deformable elements 205 that can be broken or deformed by the application of a radial force, such as by a balloon expandable member. Although the loop 206 is shown on the exterior of the component 200 in FIG. 13, it may alternatively be placed within the interior area of the component 200.
  • FIGS. 16 and 17 illustrate a portion of another embodiment of a seam of a tubular conduit, which includes a series of discrete deformable elements 207, one of which is illustrated in these figures. Element 207 is shown in its unexpanded condition in FIG. 16 as having a diameter or dimension d1, then in its expanded condition in FIG. 17 as having a diameter or dimension d2. Diameter d1 is at least somewhat smaller than the diameter d2, which thereby illustrates the expansion in the seam area of the conduit. This deformation of the element 207 is preferably permanent or semi-permanent after the force that was used to deform the element is removed. Similarly, FIGS. 21 and 22 illustrate another deformable element 214. Element 214 is shown in its unexpanded condition in FIG. 21 as having a width or length d1, then in its expanded condition in FIG. 22 as having a width or length d2. Dimension d1 is smaller than the dimension d2, which again illustrates the expansion of the seam area of the conduit.
  • FIGS. 18-20 illustrate a portion of another embodiment of a loop 206 of a conduit seam, and further including a deformable element 208. Deformable element 208 includes lobes 212 and a bar 210 extending from each lobe 212. The lobes 212 are spaced from each other around the element 208. As is best illustrated in FIG. 19, material of the conduit 204 is looped relative to the bars 210 to create the loop of a seam. Application of radial force, such as the expansion of an internally positioned balloon, can deform the element 208, thereby allowing expansion of the seam.
  • The present invention has now been described with reference to several embodiments thereof. The entire disclosure of any patent or patent application identified herein is hereby incorporated by reference. The foregoing detailed description and examples have been given for clarity of understanding only. No unnecessary limitations are to be understood therefrom. It will be apparent to those skilled in the art that many changes can be made in the embodiments described without departing from the scope of the invention. Thus, the scope of the present invention should not be limited to the structures described herein, but only by the structures described by the language of the claims and the equivalents of those structures.

Claims (20)

1. A prosthetic heart valve comprising:
a valved conduit comprising a generally tubular structure having at least one leaflet attached within its interior area;
a plurality of support structures connected to the tubular structure and spaced from each other along a length of the tubular structure, wherein each of the support structures is expandable from a first configuration to a second configuration when subjected to internal radial stress, wherein the internal area of each support structure is smaller in its first configuration than in its second configuration.
2. The heart valve of claim 1, wherein each of the support structures is attached to an outer surface of the tubular structure.
3. The heart valve of claim 1, wherein each of the support structures are attached within the interior area of the tubular structure.
4. The heart valve of claim 1, wherein each of the support structures are embedded within an outer wall of the tubular structure.
5. The heart valve of claim 1, wherein the heart valve is surgically implantable in a patient with the support structures in their first configuration, and wherein the support structures are expandable to their second configuration in response to the application of radial stress by a separate radial expansion system.
6. The heart valve of claim 1, wherein the first configuration of each of the support structures comprises a shaped portion, and wherein the shaped portion of the support structures is at least partially straightened when the support structure is in its second configuration.
7. The heart valve of claim 1, wherein the tubular structure has a central area having a smaller diameter than a diameter of at least one of a first end and a second end of the tubular structure.
8. The heart valve of claim 7, wherein the at least two leaflets are attached within the central area of the tubular structure.
9. A prosthetic heart valve comprising:
a sewing ring from which a plurality of stent posts extend, wherein the sewing ring is a generally tubular structure that is expandable from a first configuration to a second configuration, wherein an internal area of the sewing ring is smaller in its first configuration than in its second configuration;
at least one leaflet attached within an interior area of the sewing ring; and
a reconfigurable support structure, wherein at least a portion of the support structure is attached to at least one of the stent posts.
10. The heart valve of claim 9, wherein the support structure is reconfigurable from a first configuration to a second configuration when the sewing ring is subjected to internal radial stress, wherein the internal area of the support structure is smaller in its first configuration than in its second configuration.
11. The heart valve of claim 9, wherein the sewing ring comprises a frame having a gap that is smaller when the sewing ring is in its first configuration than when the sewing ring is in its second configuration, and wherein the frame and the gap are covered by a flexible covering material.
12. The heart valve of claim 11, wherein the flexible covering material surrounds the sewing ring, stent posts, and gap.
13. The heart valve of claim 11, wherein the support structure is a self-expanding structure.
14. The heart valve of claim 13, further comprising at least one restraining member positioned to compress a portion of the support structure to maintain the support structure is in its first configuration.
15. A prosthetic heart valve comprising a valved conduit comprising a generally tubular structure having at least one leaflet attached within its interior area, wherein the tubular structure comprises:
a plurality of longitudinal support members spaced from each other around the perimeter of the tubular structure;
at least one deformable member attached at a first end to a first longitudinal support member and at a second end to an adjacent second longitudinal support member, wherein the at least one deformable member is reconfigurable when the tubular structure is subjected to an internal radial stress.
16. The heart valve of claim 15, wherein the at least one deformable member is permanently deformable.
17. The heart valve of claim 15, wherein the at least one deformable member is breakable.
18. The heart valve of claim 15, further comprising at least one connector member attached at a first end to the first longitudinal member and at a second end to the second longitudinal member, wherein the at least one connector member has a higher strength than a strength of the at least one deformable member such that when the tubular structure is subjected to an internal radial stress, the at least one deformable member will deform by a sufficient amount that the distance between the first and second longitudinal support members will increase and such that the connector member will remain attached to the first and second longitudinal support members.
19. A prosthetic heart valve comprising a valved conduit comprising a generally tubular structure having a length extending along a longitudinal axis, wherein the tubular structure comprises:
a first seam extending along at least a portion of the length of the tubular structure; and
a second seam spaced from the first seam and extending along at least a portion of the length of the tubular structure;
wherein the first and second seams are positioned relative to each other to form a loop of material that reduces an internal diameter of the tubular structure from an expanded configuration to a compressed configuration.
20. The prosthetic heart valve of claim 19, wherein the first and second seams are releasable to allow expansion of the tubular structure from its compressed configuration to its expanded configuration.
US12/380,483 2008-02-28 2009-02-27 Prosthetic heart valve systems Abandoned US20090264989A1 (en)

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US13/178,112 US8613765B2 (en) 2008-02-28 2011-07-07 Prosthetic heart valve systems
US14/097,608 US8961593B2 (en) 2008-02-28 2013-12-05 Prosthetic heart valve systems

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US12/380,483 US20090264989A1 (en) 2008-02-28 2009-02-27 Prosthetic heart valve systems

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US13/178,112 Active US8613765B2 (en) 2008-02-28 2011-07-07 Prosthetic heart valve systems
US14/097,608 Active US8961593B2 (en) 2008-02-28 2013-12-05 Prosthetic heart valve systems

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Cited By (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104884001A (en) * 2012-12-31 2015-09-02 爱德华兹生命科学公司 Post-implant expandable surgical heart valve configurations
JP2016508852A (en) * 2013-03-08 2016-03-24 カーネギー メロン ユニバーシティ Expandable embedded conduit
US9333074B2 (en) 2009-04-15 2016-05-10 Edwards Lifesciences Cardiaq Llc Vascular implant and delivery system
US9339377B2 (en) 2008-09-29 2016-05-17 Edwards Lifesciences Cardiaq Llc Body cavity prosthesis
WO2016155730A1 (en) * 2015-04-02 2016-10-06 Hans-Hinrich Sievers Prosthetic heart valve
US9554897B2 (en) 2011-04-28 2017-01-31 Neovasc Tiara Inc. Methods and apparatus for engaging a valve prosthesis with tissue
US9572665B2 (en) 2013-04-04 2017-02-21 Neovasc Tiara Inc. Methods and apparatus for delivering a prosthetic valve to a beating heart
US9597183B2 (en) 2008-10-01 2017-03-21 Edwards Lifesciences Cardiaq Llc Delivery system for vascular implant
US20170136162A1 (en) * 2014-06-30 2017-05-18 Stichting Katholieke Universiteit Heart support device
US9681951B2 (en) 2013-03-14 2017-06-20 Edwards Lifesciences Cardiaq Llc Prosthesis with outer skirt and anchors
US9713529B2 (en) 2011-04-28 2017-07-25 Neovasc Tiara Inc. Sequentially deployed transcatheter mitral valve prosthesis
US9770329B2 (en) 2010-05-05 2017-09-26 Neovasc Tiara Inc. Transcatheter mitral valve prosthesis
US10016275B2 (en) 2012-05-30 2018-07-10 Neovasc Tiara Inc. Methods and apparatus for loading a prosthesis onto a delivery system
US10130469B2 (en) 2014-06-20 2018-11-20 Edwards Lifesciences Corporation Expandable surgical heart valve indicators
USD867594S1 (en) 2015-06-19 2019-11-19 Edwards Lifesciences Corporation Prosthetic heart valve
US10543085B2 (en) 2012-12-31 2020-01-28 Edwards Lifesciences Corporation One-piece heart valve stents adapted for post-implant expansion
US10583002B2 (en) 2013-03-11 2020-03-10 Neovasc Tiara Inc. Prosthetic valve with anti-pivoting mechanism
US20200229918A1 (en) * 2017-02-27 2020-07-23 Thuy Pham Novel transcatheter valve replacement device
US11076954B2 (en) * 2017-09-21 2021-08-03 The Cleveland Clinic Foundation Gradually-expandable stent apparatus and method
US20210330457A1 (en) * 2018-03-16 2021-10-28 W. L. Gore & Associates, Inc. Diametric expansion features for prosthetic valves
JP2022028755A (en) * 2011-11-16 2022-02-16 ダブリュ.エル.ゴア アンド アソシエイツ,インコーポレイティド lattice
USD944398S1 (en) 2018-06-13 2022-02-22 Edwards Lifesciences Corporation Expanded heart valve stent
US11911537B2 (en) 2013-12-05 2024-02-27 W. L. Gore & Associates, Inc. Length extensible implantable device and methods for making such devices

Families Citing this family (116)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2629534C (en) 2005-11-10 2015-02-24 Arshad Quadri Balloon-expandable, self-expanding, vascular prosthesis connecting stent
BRPI0817708A2 (en) 2007-09-26 2017-05-16 St Jude Medical prosthetic heart valve, and lamella structure for the same.
US9532868B2 (en) 2007-09-28 2017-01-03 St. Jude Medical, Inc. Collapsible-expandable prosthetic heart valves with structures for clamping native tissue
DE202009018961U1 (en) 2008-07-15 2014-11-26 St. Jude Medical, Inc. Heart valve prosthesis and arrangement for delivering a heart valve prosthesis
US9314335B2 (en) * 2008-09-19 2016-04-19 Edwards Lifesciences Corporation Prosthetic heart valve configured to receive a percutaneous prosthetic heart valve implantation
EP2344074B1 (en) * 2008-09-19 2019-03-27 Edwards Lifesciences Corporation Prosthetic heart valve configured to receive a percutaneous prosthetic heart valve implantation
BRPI1008902A2 (en) 2009-02-27 2016-03-15 St Jude Medical prosthetic heart valve.
US9730790B2 (en) 2009-09-29 2017-08-15 Edwards Lifesciences Cardiaq Llc Replacement valve and method
US8449599B2 (en) 2009-12-04 2013-05-28 Edwards Lifesciences Corporation Prosthetic valve for replacing mitral valve
EP3061422B1 (en) 2010-06-21 2021-11-03 Edwards Lifesciences CardiAQ LLC Replacement heart valve
DK2590595T3 (en) 2010-07-09 2015-12-07 Highlife Sas Transcatheter atrioventricular heart valve prosthesis
EP4098227A1 (en) * 2010-07-23 2022-12-07 Edwards Lifesciences Corporation Retaining mechanisms for prosthetic valves
EP3459500B1 (en) 2010-09-23 2020-09-16 Edwards Lifesciences CardiAQ LLC Replacement heart valves and delivery devices
US9839540B2 (en) 2011-01-14 2017-12-12 W. L. Gore & Associates, Inc. Stent
EP2606855A1 (en) * 2011-12-23 2013-06-26 Ludwig-Maximilians-Universität München Prosthetic heart valve
US9427315B2 (en) 2012-04-19 2016-08-30 Caisson Interventional, LLC Valve replacement systems and methods
US9011515B2 (en) 2012-04-19 2015-04-21 Caisson Interventional, LLC Heart valve assembly systems and methods
US9241791B2 (en) * 2012-06-29 2016-01-26 St. Jude Medical, Cardiology Division, Inc. Valve assembly for crimp profile
EP2708210B1 (en) * 2012-09-12 2022-04-06 Cook Medical Technologies LLC Stent structure for implantable medical device
US9931193B2 (en) 2012-11-13 2018-04-03 W. L. Gore & Associates, Inc. Elastic stent graft
US9144492B2 (en) 2012-12-19 2015-09-29 W. L. Gore & Associates, Inc. Truncated leaflet for prosthetic heart valves, preformed valve
US9968443B2 (en) 2012-12-19 2018-05-15 W. L. Gore & Associates, Inc. Vertical coaptation zone in a planar portion of prosthetic heart valve leaflet
US9101469B2 (en) 2012-12-19 2015-08-11 W. L. Gore & Associates, Inc. Prosthetic heart valve with leaflet shelving
US9655719B2 (en) * 2013-01-29 2017-05-23 St. Jude Medical, Cardiology Division, Inc. Surgical heart valve flexible stent frame stiffener
US9339274B2 (en) 2013-03-12 2016-05-17 St. Jude Medical, Cardiology Division, Inc. Paravalvular leak occlusion device for self-expanding heart valves
WO2014143126A1 (en) 2013-03-12 2014-09-18 St. Jude Medical, Cardiology Division, Inc. Self-actuating sealing portions for paravalvular leak protection
US10271949B2 (en) 2013-03-12 2019-04-30 St. Jude Medical, Cardiology Division, Inc. Paravalvular leak occlusion device for self-expanding heart valves
US9398951B2 (en) 2013-03-12 2016-07-26 St. Jude Medical, Cardiology Division, Inc. Self-actuating sealing portions for paravalvular leak protection
US9326856B2 (en) 2013-03-14 2016-05-03 St. Jude Medical, Cardiology Division, Inc. Cuff configurations for prosthetic heart valve
US9730791B2 (en) 2013-03-14 2017-08-15 Edwards Lifesciences Cardiaq Llc Prosthesis for atraumatically grasping intralumenal tissue and methods of delivery
US20140277427A1 (en) 2013-03-14 2014-09-18 Cardiaq Valve Technologies, Inc. Prosthesis for atraumatically grasping intralumenal tissue and methods of delivery
EP3010446B2 (en) 2013-06-19 2024-03-20 AGA Medical Corporation Collapsible valve having paravalvular leak protection
WO2015038458A1 (en) 2013-09-12 2015-03-19 St. Jude Medical, Cardiology Division, Inc. Stent designs for prosthetic heart valves
EP2853237A1 (en) 2013-09-25 2015-04-01 Universität Zürich Biological heart valve replacement, particularly for pediatric patients, and manufacturing method
US9421094B2 (en) 2013-10-23 2016-08-23 Caisson Interventional, LLC Methods and systems for heart valve therapy
EP2870946B1 (en) 2013-11-06 2018-10-31 St. Jude Medical, Cardiology Division, Inc. Paravalvular leak sealing mechanism
US9913715B2 (en) 2013-11-06 2018-03-13 St. Jude Medical, Cardiology Division, Inc. Paravalvular leak sealing mechanism
EP4176844A1 (en) 2013-11-06 2023-05-10 St. Jude Medical, Cardiology Division, Inc. Reduced profile prosthetic heart valve
EP3071149B1 (en) 2013-11-19 2022-06-01 St. Jude Medical, Cardiology Division, Inc. Sealing structures for paravalvular leak protection
US9820852B2 (en) 2014-01-24 2017-11-21 St. Jude Medical, Cardiology Division, Inc. Stationary intra-annular halo designs for paravalvular leak (PVL) reduction—active channel filling cuff designs
US20150209141A1 (en) 2014-01-24 2015-07-30 St. Jude Medical, Cardiology Division, Inc. Stationary intra-annular halo designs for paravalvular leak (pvl) reduction-passive channel filling cuff designs
US11672652B2 (en) 2014-02-18 2023-06-13 St. Jude Medical, Cardiology Division, Inc. Bowed runners for paravalvular leak protection
CN106170269B (en) 2014-02-21 2019-01-11 爱德华兹生命科学卡迪尔克有限责任公司 The delivery apparatus of controlled deployment for valve substitutes
USD755384S1 (en) 2014-03-05 2016-05-03 Edwards Lifesciences Cardiaq Llc Stent
CR20160424A (en) 2014-03-26 2016-12-08 St Jude Medical Cardiology Div Inc Transcather mitral valve stent frames
WO2015152980A1 (en) 2014-03-31 2015-10-08 St. Jude Medical, Cardiology Division, Inc. Paravalvular sealing via extended cuff mechanisms
US10195025B2 (en) 2014-05-12 2019-02-05 Edwards Lifesciences Corporation Prosthetic heart valve
WO2015175863A1 (en) 2014-05-16 2015-11-19 St. Jude Medical, Cardiology Division, Inc. Stent assembly for use in prosthetic heart valves
WO2015175524A1 (en) 2014-05-16 2015-11-19 St. Jude Medical, Cardiology Division, Inc. Subannular sealing for paravalvular leak protection
EP3142604B1 (en) 2014-05-16 2024-01-10 St. Jude Medical, Cardiology Division, Inc. Transcatheter valve with paravalvular leak sealing ring
CA3161000A1 (en) 2014-05-19 2015-11-26 Edwards Lifesciences Cardiaq Llc Replacement mitral valve with annular flap
US9532870B2 (en) 2014-06-06 2017-01-03 Edwards Lifesciences Corporation Prosthetic valve for replacing a mitral valve
US9974647B2 (en) 2014-06-12 2018-05-22 Caisson Interventional, LLC Two stage anchor and mitral valve assembly
US9827094B2 (en) 2014-09-15 2017-11-28 W. L. Gore & Associates, Inc. Prosthetic heart valve with retention elements
US10507101B2 (en) 2014-10-13 2019-12-17 W. L. Gore & Associates, Inc. Valved conduit
US9750607B2 (en) 2014-10-23 2017-09-05 Caisson Interventional, LLC Systems and methods for heart valve therapy
US9750605B2 (en) 2014-10-23 2017-09-05 Caisson Interventional, LLC Systems and methods for heart valve therapy
WO2016154166A1 (en) 2015-03-24 2016-09-29 St. Jude Medical, Cardiology Division, Inc. Prosthetic mitral valve
US10441416B2 (en) 2015-04-21 2019-10-15 Edwards Lifesciences Corporation Percutaneous mitral valve replacement device
US10376363B2 (en) 2015-04-30 2019-08-13 Edwards Lifesciences Cardiaq Llc Replacement mitral valve, delivery system for replacement mitral valve and methods of use
CA2990872C (en) 2015-06-22 2022-03-22 Edwards Lifescience Cardiaq Llc Actively controllable heart valve implant and methods of controlling same
US10092400B2 (en) 2015-06-23 2018-10-09 Edwards Lifesciences Cardiaq Llc Systems and methods for anchoring and sealing a prosthetic heart valve
EP3316823B1 (en) 2015-07-02 2020-04-08 Edwards Lifesciences Corporation Integrated hybrid heart valves
CR20170577A (en) 2015-07-02 2019-05-03 Edwards Lifesciences Corp Hybrid heart valves adapted for post-implant expansion.-
US10117744B2 (en) 2015-08-26 2018-11-06 Edwards Lifesciences Cardiaq Llc Replacement heart valves and methods of delivery
US10575951B2 (en) 2015-08-26 2020-03-03 Edwards Lifesciences Cardiaq Llc Delivery device and methods of use for transapical delivery of replacement mitral valve
US10350066B2 (en) 2015-08-28 2019-07-16 Edwards Lifesciences Cardiaq Llc Steerable delivery system for replacement mitral valve and methods of use
US10080653B2 (en) 2015-09-10 2018-09-25 Edwards Lifesciences Corporation Limited expansion heart valve
AU2016380345B2 (en) 2015-12-30 2021-10-28 Caisson Interventional, LLC Systems and methods for heart valve therapy
CN108882981B (en) 2016-01-29 2021-08-10 内奥瓦斯克迪亚拉公司 Prosthetic valve for preventing outflow obstruction
CN109069257B (en) 2016-04-21 2021-08-24 W.L.戈尔及同仁股份有限公司 Adjustable diameter endoprosthesis and related systems and methods
USD815744S1 (en) 2016-04-28 2018-04-17 Edwards Lifesciences Cardiaq Llc Valve frame for a delivery system
US10350062B2 (en) 2016-07-21 2019-07-16 Edwards Lifesciences Corporation Replacement heart valve prosthesis
EP3500214A4 (en) 2016-08-19 2019-07-24 Edwards Lifesciences Corporation Steerable delivery system for replacement mitral valve and methods of use
WO2018039543A1 (en) 2016-08-26 2018-03-01 St. Jude Medical, Cardiology Division, Inc. Prosthetic heart valve with paravalvular leak mitigation features
WO2018039631A1 (en) 2016-08-26 2018-03-01 Edwards Lifesciences Corporation Multi-portion replacement heat valve prosthesis
US10456249B2 (en) 2016-09-15 2019-10-29 St. Jude Medical, Cardiology Division, Inc. Prosthetic heart valve with paravalvular leak mitigation features
BR102016021508A2 (en) * 2016-09-19 2018-04-03 Angel Maluf Miguel METHOD FOR OBTAINING AN EXPANSIBLE HEART VALVE STENT FROM POLYURETHANE MEMBRANE AND STENT POLYURETHANE MEMBRANE VALVE FOR CATHETER IMPLANTS IN ADULT AND PEDIATRIC PATIENTS
WO2018081490A1 (en) 2016-10-28 2018-05-03 St. Jude Medical, Cardiology Division, Inc. Prosthetic mitral valve
US10758348B2 (en) 2016-11-02 2020-09-01 Edwards Lifesciences Corporation Supra and sub-annular mitral valve delivery system
WO2018090148A1 (en) 2016-11-21 2018-05-24 Neovasc Tiara Inc. Methods and systems for rapid retraction of a transcatheter heart valve delivery system
US11406533B2 (en) 2017-03-17 2022-08-09 W. L. Gore & Associates, Inc. Integrated aqueous shunt for glaucoma treatment
USD889653S1 (en) 2017-05-15 2020-07-07 St. Jude Medical, Cardiology Division, Inc. Stent having tapered struts
USD875250S1 (en) 2017-05-15 2020-02-11 St. Jude Medical, Cardiology Division, Inc. Stent having tapered aortic struts
USD875935S1 (en) 2017-05-15 2020-02-18 St. Jude Medical, Cardiology Division, Inc. Stent having tapered struts
CN110831547B (en) 2017-06-21 2022-07-15 爱德华兹生命科学公司 Double-wire limited expansion heart valve
US11123186B2 (en) 2017-07-06 2021-09-21 Edwards Lifesciences Corporation Steerable delivery system and components
WO2019036810A1 (en) 2017-08-25 2019-02-28 Neovasc Tiara Inc. Sequentially deployed transcatheter mitral valve prosthesis
EP3459469A1 (en) 2017-09-23 2019-03-27 Universität Zürich Medical occluder device
CN111132636B (en) 2017-09-27 2022-04-08 W.L.戈尔及同仁股份有限公司 Prosthetic valves with expandable frames and associated systems and methods
US11382751B2 (en) 2017-10-24 2022-07-12 St. Jude Medical, Cardiology Division, Inc. Self-expandable filler for mitigating paravalvular leak
JP7052032B2 (en) 2017-10-31 2022-04-11 ダブリュ.エル.ゴア アンド アソシエイツ,インコーポレイティド Medical valves and valve membranes that promote inward tissue growth
CA3158944A1 (en) 2017-10-31 2019-05-09 W.L. Gore & Associates, Inc. Valved conduit
EP3720390A2 (en) 2018-01-25 2020-10-14 Edwards Lifesciences Corporation Delivery system for aided replacement valve recapture and repositioning post- deployment
US11051934B2 (en) 2018-02-28 2021-07-06 Edwards Lifesciences Corporation Prosthetic mitral valve with improved anchors and seal
US11813413B2 (en) 2018-03-27 2023-11-14 St. Jude Medical, Cardiology Division, Inc. Radiopaque outer cuff for transcatheter valve
EP3556323B1 (en) * 2018-04-18 2023-07-19 St. Jude Medical, Cardiology Division, Inc. Prosthetic heart valve
US11540917B2 (en) 2018-05-03 2023-01-03 Medtronic Vascular, Inc. Tip assemblies, systems, and methods for fracturing a frame of a deployed prosthesis
WO2020060828A1 (en) 2018-09-20 2020-03-26 St. Jude Medical, Cardiology Division, Inc. Attachment of leaflets to prosthetic heart valve
US11364117B2 (en) 2018-10-15 2022-06-21 St. Jude Medical, Cardiology Division, Inc. Braid connections for prosthetic heart valves
USD977642S1 (en) 2018-10-29 2023-02-07 W. L. Gore & Associates, Inc. Pulmonary valve conduit
US11737872B2 (en) 2018-11-08 2023-08-29 Neovasc Tiara Inc. Ventricular deployment of a transcatheter mitral valve prosthesis
US11471277B2 (en) 2018-12-10 2022-10-18 St. Jude Medical, Cardiology Division, Inc. Prosthetic tricuspid valve replacement design
US11678983B2 (en) 2018-12-12 2023-06-20 W. L. Gore & Associates, Inc. Implantable component with socket
US11273030B2 (en) 2018-12-26 2022-03-15 St. Jude Medical, Cardiology Division, Inc. Elevated outer cuff for reducing paravalvular leakage and increasing stent fatigue life
US20210315691A1 (en) * 2019-01-28 2021-10-14 Tricares SAS Three part stent second generation
US11497601B2 (en) 2019-03-01 2022-11-15 W. L. Gore & Associates, Inc. Telescoping prosthetic valve with retention element
WO2020191386A1 (en) * 2019-03-21 2020-09-24 The Trustees Of Columbia University In The City Of New York Transcatheter dilatable biostable polymeric stented valved tube prosthesis
CA3135753C (en) 2019-04-01 2023-10-24 Neovasc Tiara Inc. Controllably deployable prosthetic valve
CA3136334A1 (en) 2019-04-10 2020-10-15 Neovasc Tiara Inc. Prosthetic valve with natural blood flow
EP3965694A1 (en) 2019-05-06 2022-03-16 W. L. Gore & Associates, Inc. Valved conduit with expandable frame
WO2020236931A1 (en) 2019-05-20 2020-11-26 Neovasc Tiara Inc. Introducer with hemostasis mechanism
CN114144144A (en) 2019-06-20 2022-03-04 内奥瓦斯克迪亚拉公司 Low-profile prosthetic mitral valve
US11382741B2 (en) 2019-12-18 2022-07-12 St. Jude Medical, Cardiology Division, Inc. Devices and methods for surgical valve expansion
WO2023244858A1 (en) * 2022-06-17 2023-12-21 Georgia Tech Research Corporation Thermoformed polymeric valved conduits for heart valve applications
US11701224B1 (en) * 2022-06-28 2023-07-18 Seven Summits Medical, Inc. Prosthetic heart valve for multiple positions and applications

Citations (95)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3714671A (en) * 1970-11-30 1973-02-06 Cutter Lab Tissue-type heart valve with a graft support ring or stent
US3868956A (en) * 1972-06-05 1975-03-04 Ralph J Alfidi Vessel implantable appliance and method of implanting it
US4501030A (en) * 1981-08-17 1985-02-26 American Hospital Supply Corporation Method of leaflet attachment for prosthetic heart valves
US4574803A (en) * 1979-01-19 1986-03-11 Karl Storz Tissue cutter
US4647283A (en) * 1982-03-23 1987-03-03 American Hospital Supply Corporation Implantable biological tissue and process for preparation thereof
US4733665A (en) * 1985-11-07 1988-03-29 Expandable Grafts Partnership Expandable intraluminal graft, and method and apparatus for implanting an expandable intraluminal graft
US4796629A (en) * 1987-06-03 1989-01-10 Joseph Grayzel Stiffened dilation balloon catheter device
US4797901A (en) * 1985-08-22 1989-01-10 Siemens Aktiengesellschaft Circuit arrangement for testing a passive bus network with the carrier sense multiple access with collisions detection method
US4909252A (en) * 1988-05-26 1990-03-20 The Regents Of The Univ. Of California Perfusion balloon catheter
US4986830A (en) * 1989-09-22 1991-01-22 Schneider (U.S.A.) Inc. Valvuloplasty catheter with balloon which remains stable during inflation
US4994077A (en) * 1989-04-21 1991-02-19 Dobben Richard L Artificial heart valve for implantation in a blood vessel
US5085635A (en) * 1990-05-18 1992-02-04 Cragg Andrew H Valved-tip angiographic catheter
US5089015A (en) * 1989-11-28 1992-02-18 Promedica International Method for implanting unstented xenografts and allografts
US5295958A (en) * 1991-04-04 1994-03-22 Shturman Cardiology Systems, Inc. Method and apparatus for in vivo heart valve decalcification
US5397351A (en) * 1991-05-13 1995-03-14 Pavcnik; Dusan Prosthetic valve for percutaneous insertion
US5480424A (en) * 1993-11-01 1996-01-02 Cox; James L. Heart valve replacement using flexible tubes
US5489297A (en) * 1992-01-27 1996-02-06 Duran; Carlos M. G. Bioprosthetic heart valve with absorbable stent
US5489294A (en) * 1994-02-01 1996-02-06 Medtronic, Inc. Steroid eluting stitch-in chronic cardiac lead
US5496346A (en) * 1987-01-06 1996-03-05 Advanced Cardiovascular Systems, Inc. Reinforced balloon dilatation catheter with slitted exchange sleeve and method
US5500014A (en) * 1989-05-31 1996-03-19 Baxter International Inc. Biological valvular prothesis
US5591195A (en) * 1995-10-30 1997-01-07 Taheri; Syde Apparatus and method for engrafting a blood vessel
US5609626A (en) * 1989-05-31 1997-03-11 Baxter International Inc. Stent devices and support/restrictor assemblies for use in conjunction with prosthetic vascular grafts
US5713953A (en) * 1991-05-24 1998-02-03 Sorin Biomedica Cardio S.P.A. Cardiac valve prosthesis particularly for replacement of the aortic valve
US5716417A (en) * 1995-06-07 1998-02-10 St. Jude Medical, Inc. Integral supporting structure for bioprosthetic heart valve
US5855597A (en) * 1997-05-07 1999-01-05 Iowa-India Investments Co. Limited Stent valve and stent graft for percutaneous surgery
US5855601A (en) * 1996-06-21 1999-01-05 The Trustees Of Columbia University In The City Of New York Artificial heart valve and method and device for implanting the same
US5861028A (en) * 1996-09-09 1999-01-19 Shelhigh Inc Natural tissue heart valve and stent prosthesis and method for making the same
US5876448A (en) * 1992-05-08 1999-03-02 Schneider (Usa) Inc. Esophageal stent
US5888201A (en) * 1996-02-08 1999-03-30 Schneider (Usa) Inc Titanium alloy self-expanding stent
US6022370A (en) * 1996-10-01 2000-02-08 Numed, Inc. Expandable stent
US6027525A (en) * 1996-05-23 2000-02-22 Samsung Electronics., Ltd. Flexible self-expandable stent and method for making the same
US6029671A (en) * 1991-07-16 2000-02-29 Heartport, Inc. System and methods for performing endovascular procedures
US6042589A (en) * 1998-03-17 2000-03-28 Medicorp, S.A. Reversible-action endoprosthesis delivery device
US6171335B1 (en) * 1997-01-24 2001-01-09 Aortech Europe Limited Heart valve prosthesis
US6338735B1 (en) * 1991-07-16 2002-01-15 John H. Stevens Methods for removing embolic material in blood flowing through a patient's ascending aorta
US20020010508A1 (en) * 1997-11-25 2002-01-24 Chobotov Michael V. Layered endovascular graft
US6348063B1 (en) * 1999-03-11 2002-02-19 Mindguard Ltd. Implantable stroke treating device
US6350277B1 (en) * 1999-01-15 2002-02-26 Scimed Life Systems, Inc. Stents with temporary retaining bands
US6503272B2 (en) * 2001-03-21 2003-01-07 Cordis Corporation Stent-based venous valves
US20030014104A1 (en) * 1996-12-31 2003-01-16 Alain Cribier Value prosthesis for implantation in body channels
US6508833B2 (en) * 1998-06-02 2003-01-21 Cook Incorporated Multiple-sided intraluminal medical device
US20030023303A1 (en) * 1999-11-19 2003-01-30 Palmaz Julio C. Valvular prostheses having metal or pseudometallic construction and methods of manufacture
US20030023300A1 (en) * 1999-12-31 2003-01-30 Bailey Steven R. Endoluminal cardiac and venous valve prostheses and methods of manufacture and delivery thereof
US20030028247A1 (en) * 2001-01-29 2003-02-06 Cali Douglas S. Method of cutting material for use in implantable medical device
US20030036791A1 (en) * 2001-08-03 2003-02-20 Bonhoeffer Philipp Implant implantation unit and procedure for implanting the unit
US20030040772A1 (en) * 1999-02-01 2003-02-27 Hideki Hyodoh Delivery devices
US20030040792A1 (en) * 2000-09-12 2003-02-27 Shlomo Gabbay Heart valve prosthesis and sutureless implantation of a heart valve prosthesis
US6673089B1 (en) * 1999-03-11 2004-01-06 Mindguard Ltd. Implantable stroke treating device
US6673109B2 (en) * 1993-11-01 2004-01-06 3F Therapeutics, Inc. Replacement atrioventricular heart valve
US6676698B2 (en) * 2000-06-26 2004-01-13 Rex Medicol, L.P. Vascular device with valve for approximating vessel wall
US6682558B2 (en) * 2001-05-10 2004-01-27 3F Therapeutics, Inc. Delivery system for a stentless valve bioprosthesis
US6682559B2 (en) * 2000-01-27 2004-01-27 3F Therapeutics, Inc. Prosthetic heart valve
US6685739B2 (en) * 1999-10-21 2004-02-03 Scimed Life Systems, Inc. Implantable prosthetic valve
US6689144B2 (en) * 2002-02-08 2004-02-10 Scimed Life Systems, Inc. Rapid exchange catheter and methods for delivery of vaso-occlusive devices
US6689164B1 (en) * 1999-10-12 2004-02-10 Jacques Seguin Annuloplasty device for use in minimally invasive procedure
US6692513B2 (en) * 2000-06-30 2004-02-17 Viacor, Inc. Intravascular filter with debris entrapment mechanism
US6692512B2 (en) * 1998-10-13 2004-02-17 Edwards Lifesciences Corporation Percutaneous filtration catheter for valve repair surgery and methods of use
US20040034411A1 (en) * 2002-08-16 2004-02-19 Quijano Rodolfo C. Percutaneously delivered heart valve and delivery means thereof
US6695878B2 (en) * 2000-06-26 2004-02-24 Rex Medical, L.P. Vascular device for valve leaflet apposition
US20040039436A1 (en) * 2001-10-11 2004-02-26 Benjamin Spenser Implantable prosthetic valve
US20050010287A1 (en) * 2000-09-20 2005-01-13 Ample Medical, Inc. Devices, systems, and methods for supplementing, repairing, or replacing a native heart valve leaflet
US20050010285A1 (en) * 1999-01-27 2005-01-13 Lambrecht Gregory H. Cardiac valve procedure methods and devices
US20050015112A1 (en) * 2000-01-27 2005-01-20 Cohn William E. Cardiac valve procedure methods and devices
US6846325B2 (en) * 2000-09-07 2005-01-25 Viacor, Inc. Fixation band for affixing a prosthetic heart valve to tissue
US20050027348A1 (en) * 2003-07-31 2005-02-03 Case Brian C. Prosthetic valve devices and methods of making such devices
US20050033398A1 (en) * 2001-07-31 2005-02-10 Jacques Seguin Assembly for setting a valve prosthesis in a corporeal duct
US20050043790A1 (en) * 2001-07-04 2005-02-24 Jacques Seguin Kit enabling a prosthetic valve to be placed in a body enabling a prosthetic valve to be put into place in a duct in the body
US20060004439A1 (en) * 2004-06-30 2006-01-05 Benjamin Spenser Device and method for assisting in the implantation of a prosthetic valve
US20060004469A1 (en) * 2004-06-16 2006-01-05 Justin Sokel Tissue prosthesis processing technology
US20060009841A1 (en) * 2003-05-05 2006-01-12 Rex Medical Percutaneous aortic valve
US6986742B2 (en) * 2001-08-21 2006-01-17 Boston Scientific Scimed, Inc. Pressure transducer protection valve
US6989027B2 (en) * 2003-04-30 2006-01-24 Medtronic Vascular Inc. Percutaneously delivered temporary valve assembly
US6989028B2 (en) * 2000-01-31 2006-01-24 Edwards Lifesciences Ag Medical system and method for remodeling an extravascular tissue structure
US6991649B2 (en) * 2003-08-29 2006-01-31 Hans-Hinrich Sievers Artificial heart valve
US20070005131A1 (en) * 2005-06-13 2007-01-04 Taylor David M Heart valve delivery system
US20070005129A1 (en) * 2000-02-28 2007-01-04 Christoph Damm Anchoring system for implantable heart valve prostheses
US20070010878A1 (en) * 2003-11-12 2007-01-11 Medtronic Vascular, Inc. Coronary sinus approach for repair of mitral valve regurgitation
US20070016286A1 (en) * 2003-07-21 2007-01-18 Herrmann Howard C Percutaneous heart valve
US20070027518A1 (en) * 2003-04-01 2007-02-01 Case Brian C Percutaneously deployed vascular valves
US20070027533A1 (en) * 2005-07-28 2007-02-01 Medtronic Vascular, Inc. Cardiac valve annulus restraining device
US7175656B2 (en) * 2003-04-18 2007-02-13 Alexander Khairkhahan Percutaneous transcatheter heart valve replacement
US20070043435A1 (en) * 1999-11-17 2007-02-22 Jacques Seguin Non-cylindrical prosthetic valve system for transluminal delivery
US20080004696A1 (en) * 2006-06-29 2008-01-03 Valvexchange Inc. Cardiovascular valve assembly with resizable docking station
US7316706B2 (en) * 2003-06-20 2008-01-08 Medtronic Vascular, Inc. Tensioning device, system, and method for treating mitral valve regurgitation
US20080015671A1 (en) * 2004-11-19 2008-01-17 Philipp Bonhoeffer Method And Apparatus For Treatment Of Cardiac Valves
US20080021552A1 (en) * 2001-10-09 2008-01-24 Shlomo Gabbay Apparatus To Facilitate Implantation
US7329278B2 (en) * 1999-11-17 2008-02-12 Corevalve, Inc. Prosthetic valve for transluminal delivery
US7335218B2 (en) * 2002-08-28 2008-02-26 Heart Leaflet Technologies, Inc. Delivery device for leaflet valve
US20080048656A1 (en) * 2006-07-14 2008-02-28 Fengshun Tan Thermal controlling method, magnetic field generator and mri apparatus
US20090005863A1 (en) * 2006-02-16 2009-01-01 Goetz Wolfgang Minimally invasive heart valve replacement
US20090012600A1 (en) * 2005-04-05 2009-01-08 Mikolaj Witold Styrc Kit Which Is Intended to Be Implanted in a Blood Vessel, and Associated Tubular Endoprosthesis
US7481838B2 (en) * 1999-01-26 2009-01-27 Edwards Lifesciences Corporation Flexible heart valve and associated connecting band
US20090048656A1 (en) * 2005-11-09 2009-02-19 Ning Wen Delivery Device for Delivering a Self-Expanding Stent
US20090054976A1 (en) * 2007-08-20 2009-02-26 Yosi Tuval Stent loading tool and method for use thereof
US20100049306A1 (en) * 2008-02-25 2010-02-25 Medtronic Vascular, Inc. Infundibular Reducer Devices

Family Cites Families (385)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3334629A (en) 1964-11-09 1967-08-08 Bertram D Cohn Occlusive device for inferior vena cava
GB1127325A (en) 1965-08-23 1968-09-18 Henry Berry Improved instrument for inserting artificial heart valves
US3671979A (en) 1969-09-23 1972-06-27 Univ Utah Catheter mounted artificial heart valve for implanting in close proximity to a defective natural heart valve
US3657744A (en) 1970-05-08 1972-04-25 Univ Minnesota Method for fixing prosthetic implants in a living body
US3755823A (en) 1971-04-23 1973-09-04 Hancock Laboratories Inc Flexible stent for heart valve
US4035849A (en) 1975-11-17 1977-07-19 William W. Angell Heart valve stent and process for preparing a stented heart valve prosthesis
CA1069652A (en) 1976-01-09 1980-01-15 Alain F. Carpentier Supported bioprosthetic heart valve with compliant orifice ring
US4056854A (en) 1976-09-28 1977-11-08 The United States Of America As Represented By The Department Of Health, Education And Welfare Aortic heart valve catheter
US4297749A (en) 1977-04-25 1981-11-03 Albany International Corp. Heart valve prosthesis
US4233690A (en) 1978-05-19 1980-11-18 Carbomedics, Inc. Prosthetic device couplings
US4265694A (en) 1978-12-14 1981-05-05 The United States Of America As Represented By The Department Of Health, Education And Welfare Method of making unitized three leaflet heart valve
US4222126A (en) 1978-12-14 1980-09-16 The United States Of America As Represented By The Secretary Of The Department Of Health, Education & Welfare Unitized three leaflet heart valve
GB2056023B (en) 1979-08-06 1983-08-10 Ross D N Bodnar E Stent for a cardiac valve
US4470157A (en) 1981-04-27 1984-09-11 Love Jack W Tricuspid prosthetic tissue heart valve
SE445884B (en) 1982-04-30 1986-07-28 Medinvent Sa DEVICE FOR IMPLANTATION OF A RODFORM PROTECTION
IT1212547B (en) 1982-08-09 1989-11-30 Iorio Domenico INSTRUMENT FOR SURGICAL USE INTENDED TO MAKE INTERVENTIONS FOR THE IMPLANTATION OF BIOPROTESIS IN HUMAN ORGANS EASIER AND SAFER
US4834755A (en) 1983-04-04 1989-05-30 Pfizer Hospital Products Group, Inc. Triaxially-braided fabric prosthesis
US4610688A (en) 1983-04-04 1986-09-09 Pfizer Hospital Products Group, Inc. Triaxially-braided fabric prosthesis
US4612011A (en) 1983-07-22 1986-09-16 Hans Kautzky Central occluder semi-biological heart valve
US4665906A (en) 1983-10-14 1987-05-19 Raychem Corporation Medical devices incorporating sim alloy elements
US4681908A (en) 1983-11-09 1987-07-21 Dow Corning Corporation Hard organopolysiloxane release coating
US4787899A (en) 1983-12-09 1988-11-29 Lazarus Harrison M Intraluminal graft device, system and method
US4627436A (en) 1984-03-01 1986-12-09 Innoventions Biomedical Inc. Angioplasty catheter and method for use thereof
US4592340A (en) 1984-05-02 1986-06-03 Boyles Paul W Artificial catheter means
US4883458A (en) 1987-02-24 1989-11-28 Surgical Systems & Instruments, Inc. Atherectomy system and method of using the same
US5007896A (en) 1988-12-19 1991-04-16 Surgical Systems & Instruments, Inc. Rotary-catheter for atherectomy
US4979939A (en) 1984-05-14 1990-12-25 Surgical Systems & Instruments, Inc. Atherectomy system with a guide wire
DE3426300A1 (en) 1984-07-17 1986-01-30 Doguhan Dr.med. 6000 Frankfurt Baykut TWO-WAY VALVE AND ITS USE AS A HEART VALVE PROSTHESIS
US4580568A (en) 1984-10-01 1986-04-08 Cook, Incorporated Percutaneous endovascular stent and method for insertion thereof
US5232445A (en) 1984-11-23 1993-08-03 Tassilo Bonzel Dilatation catheter
US4662885A (en) 1985-09-03 1987-05-05 Becton, Dickinson And Company Percutaneously deliverable intravascular filter prosthesis
DE3640745A1 (en) 1985-11-30 1987-06-04 Ernst Peter Prof Dr M Strecker Catheter for producing or extending connections to or between body cavities
US4710192A (en) 1985-12-30 1987-12-01 Liotta Domingo S Diaphragm and method for occlusion of the descending thoracic aorta
US4878906A (en) 1986-03-25 1989-11-07 Servetus Partnership Endoprosthesis for repairing a damaged vessel
US4777951A (en) 1986-09-19 1988-10-18 Mansfield Scientific, Inc. Procedure and catheter instrument for treating patients for aortic stenosis
US4878495A (en) 1987-05-15 1989-11-07 Joseph Grayzel Valvuloplasty device with satellite expansion means
US4872874A (en) 1987-05-29 1989-10-10 Taheri Syde A Method and apparatus for transarterial aortic graft insertion and implantation
US4819751A (en) 1987-10-16 1989-04-11 Baxter Travenol Laboratories, Inc. Valvuloplasty catheter and method
US5032128A (en) 1988-07-07 1991-07-16 Medtronic, Inc. Heart valve prosthesis
US4917102A (en) 1988-09-14 1990-04-17 Advanced Cardiovascular Systems, Inc. Guidewire assembly with steerable adjustable tip
US4856516A (en) 1989-01-09 1989-08-15 Cordis Corporation Endovascular stent apparatus and method
US4966604A (en) 1989-01-23 1990-10-30 Interventional Technologies Inc. Expandable atherectomy cutter with flexibly bowed blades
US5047041A (en) 1989-08-22 1991-09-10 Samuels Peter B Surgical apparatus for the excision of vein valves in situ
US5037434A (en) 1990-04-11 1991-08-06 Carbomedics, Inc. Bioprosthetic heart valve with elastic commissures
US5059177A (en) 1990-04-19 1991-10-22 Cordis Corporation Triple lumen balloon catheter
DK124690D0 (en) 1990-05-18 1990-05-18 Henning Rud Andersen FAT PROTECTION FOR IMPLEMENTATION IN THE BODY FOR REPLACEMENT OF NATURAL FLEET AND CATS FOR USE IN IMPLEMENTING A SUCH FAT PROTECTION
US5411552A (en) 1990-05-18 1995-05-02 Andersen; Henning R. Valve prothesis for implantation in the body and a catheter for implanting such valve prothesis
US5161547A (en) 1990-11-28 1992-11-10 Numed, Inc. Method of forming an intravascular radially expandable stent
US5217483A (en) 1990-11-28 1993-06-08 Numed, Inc. Intravascular radially expandable stent
US6165292A (en) 1990-12-18 2000-12-26 Advanced Cardiovascular Systems, Inc. Superelastic guiding member
US5152771A (en) 1990-12-31 1992-10-06 The Board Of Supervisors Of Louisiana State University Valve cutter for arterial by-pass surgery
US5272909A (en) 1991-04-25 1993-12-28 Baxter International Inc. Method and device for testing venous valves
US5167628A (en) 1991-05-02 1992-12-01 Boyles Paul W Aortic balloon catheter assembly for indirect infusion of the coronary arteries
US5350398A (en) 1991-05-13 1994-09-27 Dusan Pavcnik Self-expanding filter for percutaneous insertion
US6866650B2 (en) 1991-07-16 2005-03-15 Heartport, Inc. System for cardiac procedures
US5795325A (en) 1991-07-16 1998-08-18 Heartport, Inc. Methods and apparatus for anchoring an occluding member
US5584803A (en) 1991-07-16 1996-12-17 Heartport, Inc. System for cardiac procedures
US5766151A (en) 1991-07-16 1998-06-16 Heartport, Inc. Endovascular system for arresting the heart
US5558644A (en) 1991-07-16 1996-09-24 Heartport, Inc. Retrograde delivery catheter and method for inducing cardioplegic arrest
US20060058775A1 (en) 1991-07-16 2006-03-16 Stevens John H System and methods for performing endovascular procedures
US5507767A (en) 1992-01-15 1996-04-16 Cook Incorporated Spiral stent
US5163953A (en) 1992-02-10 1992-11-17 Vince Dennis J Toroidal artificial heart valve stent
US5683448A (en) 1992-02-21 1997-11-04 Boston Scientific Technology, Inc. Intraluminal stent and graft
US7101392B2 (en) 1992-03-31 2006-09-05 Boston Scientific Corporation Tubular medical endoprostheses
US5332402A (en) 1992-05-12 1994-07-26 Teitelbaum George P Percutaneously-inserted cardiac valve
US5383926A (en) 1992-11-23 1995-01-24 Children's Medical Center Corporation Re-expandable endoprosthesis
WO1994015549A1 (en) 1992-12-30 1994-07-21 Schneider (Usa) Inc. Apparatus for deploying body implantable stents
US5431676A (en) 1993-03-05 1995-07-11 Innerdyne Medical, Inc. Trocar system having expandable port
US5415633A (en) 1993-07-28 1995-05-16 Active Control Experts, Inc. Remotely steered catheterization device
KR970004845Y1 (en) 1993-09-27 1997-05-21 주식회사 수호메디테크 Stent for expanding a lumen
US5545209A (en) 1993-09-30 1996-08-13 Texas Petrodet, Inc. Controlled deployment of a medical device
US5609627A (en) 1994-02-09 1997-03-11 Boston Scientific Technology, Inc. Method for delivering a bifurcated endoluminal prosthesis
US5549663A (en) 1994-03-09 1996-08-27 Cordis Corporation Endoprosthesis having graft member and exposed welded end junctions, method and procedure
DE4415359C2 (en) 1994-05-02 1997-10-23 Aesculap Ag Surgical tubular shaft instrument
US5765418A (en) 1994-05-16 1998-06-16 Medtronic, Inc. Method for making an implantable medical device from a refractory metal
US5824041A (en) 1994-06-08 1998-10-20 Medtronic, Inc. Apparatus and methods for placement and repositioning of intraluminal prostheses
JP3970341B2 (en) 1994-06-20 2007-09-05 テルモ株式会社 Vascular catheter
US5554185A (en) 1994-07-18 1996-09-10 Block; Peter C. Inflatable prosthetic cardiovascular valve for percutaneous transluminal implantation of same
US5674277A (en) 1994-12-23 1997-10-07 Willy Rusch Ag Stent for placement in a body tube
US5575818A (en) 1995-02-14 1996-11-19 Corvita Corporation Endovascular stent with locking ring
US6579314B1 (en) 1995-03-10 2003-06-17 C.R. Bard, Inc. Covered stent with encapsulated ends
CA2215970A1 (en) 1995-03-30 1996-10-03 Heartport, Inc. System and methods for performing endovascular procedures
US5849005A (en) 1995-06-07 1998-12-15 Heartport, Inc. Method and apparatus for minimizing the risk of air embolism when performing a procedure in a patient's thoracic cavity
US5667523A (en) 1995-04-28 1997-09-16 Impra, Inc. Dual supported intraluminal graft
US5824064A (en) 1995-05-05 1998-10-20 Taheri; Syde A. Technique for aortic valve replacement with simultaneous aortic arch graft insertion and apparatus therefor
US5580922A (en) 1995-06-06 1996-12-03 Weyerhaeuser Company Cellulose products treated with isocyanate compositions
DE19532846A1 (en) 1995-09-06 1997-03-13 Georg Dr Berg Valve for use in heart
US6348066B1 (en) 1995-11-07 2002-02-19 Corvita Corporation Modular endoluminal stent-grafts and methods for their use
ATE218052T1 (en) 1995-11-27 2002-06-15 Schneider Europ Gmbh STENT FOR USE IN A PHYSICAL PASSAGE
DE19546692C2 (en) 1995-12-14 2002-11-07 Hans-Reiner Figulla Self-expanding heart valve prosthesis for implantation in the human body via a catheter system
US5843158A (en) 1996-01-05 1998-12-01 Medtronic, Inc. Limited expansion endoluminal prostheses and methods for their use
US5716370A (en) 1996-02-23 1998-02-10 Williamson, Iv; Warren Means for replacing a heart valve in a minimally invasive manner
US20020068949A1 (en) 1996-02-23 2002-06-06 Williamson Warren P. Extremely long wire fasteners for use in minimally invasive surgery and means and method for handling those fasteners
US5746709A (en) 1996-04-25 1998-05-05 Medtronic, Inc. Intravascular pump and bypass assembly and method for using the same
US5891191A (en) 1996-04-30 1999-04-06 Schneider (Usa) Inc Cobalt-chromium-molybdenum alloy stent and stent-graft
AU3122197A (en) 1996-05-14 1997-12-05 Embol-X, Inc. Aortic occluder with associated filter and methods of use during cardiac surgery
US6764509B2 (en) 1996-09-06 2004-07-20 Carbomedics Inc. Prosthetic heart valve with surface modification
US6702851B1 (en) 1996-09-06 2004-03-09 Joseph A. Chinn Prosthetic heart valve with surface modification
US5968068A (en) 1996-09-12 1999-10-19 Baxter International Inc. Endovascular delivery system
US6325826B1 (en) 1998-01-14 2001-12-04 Advanced Stent Technologies, Inc. Extendible stent apparatus
US5749890A (en) 1996-12-03 1998-05-12 Shaknovich; Alexander Method and system for stent placement in ostial lesions
NL1004827C2 (en) 1996-12-18 1998-06-19 Surgical Innovations Vof Device for regulating blood circulation.
US6241757B1 (en) 1997-02-04 2001-06-05 Solco Surgical Instrument Co., Ltd. Stent for expanding body's lumen
EP1009467A4 (en) 1997-02-19 2001-07-25 Condado Med Devices Corp Multi-purpose catheters, catheter systems, and radiation treatment
US5830229A (en) 1997-03-07 1998-11-03 Micro Therapeutics Inc. Hoop stent
US5851232A (en) 1997-03-15 1998-12-22 Lois; William A. Venous stent
US5817126A (en) 1997-03-17 1998-10-06 Surface Genesis, Inc. Compound stent
US5824053A (en) 1997-03-18 1998-10-20 Endotex Interventional Systems, Inc. Helical mesh endoprosthesis and methods of use
WO1998047447A1 (en) 1997-04-23 1998-10-29 Dubrul William R Bifurcated stent and distal protection system
US5957949A (en) 1997-05-01 1999-09-28 World Medical Manufacturing Corp. Percutaneous placement valve stent
US6245102B1 (en) 1997-05-07 2001-06-12 Iowa-India Investments Company Ltd. Stent, stent graft and stent valve
US6162245A (en) 1997-05-07 2000-12-19 Iowa-India Investments Company Limited Stent valve and stent graft
US5911734A (en) 1997-05-08 1999-06-15 Embol-X, Inc. Percutaneous catheter and guidewire having filter and medical device deployment capabilities
US6258120B1 (en) 1997-12-23 2001-07-10 Embol-X, Inc. Implantable cerebral protection device and methods of use
US6855143B2 (en) 1997-06-13 2005-02-15 Arthrocare Corporation Electrosurgical systems and methods for recanalization of occluded body lumens
US5906619A (en) 1997-07-24 1999-05-25 Medtronic, Inc. Disposable delivery device for endoluminal prostheses
US5984957A (en) 1997-08-12 1999-11-16 Schneider (Usa) Inc Radially expanded prostheses with axial diameter control
US6162208A (en) 1997-09-11 2000-12-19 Genzyme Corporation Articulating endoscopic implant rotator surgical apparatus and method for using same
US5954766A (en) 1997-09-16 1999-09-21 Zadno-Azizi; Gholam-Reza Body fluid flow control device
US6056722A (en) 1997-09-18 2000-05-02 Iowa-India Investments Company Limited Of Douglas Delivery mechanism for balloons, drugs, stents and other physical/mechanical agents and methods of use
US5925063A (en) 1997-09-26 1999-07-20 Khosravi; Farhad Coiled sheet valve, filter or occlusive device and methods of use
US6361545B1 (en) 1997-09-26 2002-03-26 Cardeon Corporation Perfusion filter catheter
ES2227877T3 (en) 1997-12-16 2005-04-01 B. Braun Celsa MEDICAL SET FOR THE TREATMENT OF AN ANATOMICAL CONDUCT AFFECTION.
US6530952B2 (en) 1997-12-29 2003-03-11 The Cleveland Clinic Foundation Bioprosthetic cardiovascular valve system
EP1049425B1 (en) 1997-12-29 2009-11-25 Cleveland Clinic Foundation The System for minimally invasive insertion of a bioprosthetic heart valve
US5944738A (en) 1998-02-06 1999-08-31 Aga Medical Corporation Percutaneous catheter directed constricting occlusion device
JP2003522550A (en) 1998-02-10 2003-07-29 アーテミス・メディカル・インコーポレイテッド Occlusion, fixation, tensioning, and diverting devices and methods of use
EP1054634A4 (en) 1998-02-10 2006-03-29 Artemis Medical Inc Entrapping apparatus and method for use
US6059809A (en) 1998-02-16 2000-05-09 Medicorp, S.A. Protective angioplasty device
US6074418A (en) 1998-04-20 2000-06-13 St. Jude Medical, Inc. Driver tool for heart valve prosthesis fasteners
US6218662B1 (en) 1998-04-23 2001-04-17 Western Atlas International, Inc. Downhole carbon dioxide gas analyzer
US6450989B2 (en) 1998-04-27 2002-09-17 Artemis Medical, Inc. Dilating and support apparatus with disease inhibitors and methods for use
US6890330B2 (en) 2000-10-27 2005-05-10 Viacor, Inc. Intracardiovascular access (ICVATM) system
US7452371B2 (en) 1999-06-02 2008-11-18 Cook Incorporated Implantable vascular device
US6630001B2 (en) 1998-06-24 2003-10-07 International Heart Institute Of Montana Foundation Compliant dehyrated tissue for implantation and process of making the same
US6159239A (en) 1998-08-14 2000-12-12 Prodesco, Inc. Woven stent/graft structure
US6179860B1 (en) 1998-08-19 2001-01-30 Artemis Medical, Inc. Target tissue localization device and method
US6203550B1 (en) 1998-09-30 2001-03-20 Medtronic, Inc. Disposable delivery device for endoluminal prostheses
US6475239B1 (en) 1998-10-13 2002-11-05 Sulzer Carbomedics Inc. Method for making polymer heart valves with leaflets having uncut free edges
US6146366A (en) 1998-11-03 2000-11-14 Ras Holding Corp Device for the treatment of macular degeneration and other eye disorders
DE19857887B4 (en) 1998-12-15 2005-05-04 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Anchoring support for a heart valve prosthesis
FR2788217A1 (en) 1999-01-12 2000-07-13 Brice Letac PROSTHETIC VALVE IMPLANTABLE BY CATHETERISM, OR SURGICAL
AU764886B2 (en) 1999-01-27 2003-09-04 Viacor Incorporated Cardiac valve procedure methods and devices
WO2000044309A2 (en) 1999-02-01 2000-08-03 Board Of Regents, The University Of Texas System Woven bifurcated and trifurcated stents and methods for making the same
DE19904975A1 (en) 1999-02-06 2000-09-14 Impella Cardiotech Ag Device for intravascular heart valve surgery
US6425916B1 (en) 1999-02-10 2002-07-30 Michi E. Garrison Methods and devices for implanting cardiac valves
WO2000047136A1 (en) 1999-02-12 2000-08-17 Johns Hopkins University Venous valve implant bioprosthesis and endovascular treatment for venous insufficiency
US6110201A (en) 1999-02-18 2000-08-29 Venpro Bifurcated biological pulmonary valved conduit
DE19907646A1 (en) 1999-02-23 2000-08-24 Georg Berg Valve for blood vessels uses flap holders and counterpart holders on stent to latch together in place and all channeled for guide wire.
US6210408B1 (en) 1999-02-24 2001-04-03 Scimed Life Systems, Inc. Guide wire system for RF recanalization of vascular blockages
US7147663B1 (en) 1999-04-23 2006-12-12 St. Jude Medical Atg, Inc. Artificial heart valve attachment apparatus and methods
US6309417B1 (en) 1999-05-12 2001-10-30 Paul A. Spence Heart valve and apparatus for replacement thereof
US6790229B1 (en) 1999-05-25 2004-09-14 Eric Berreklouw Fixing device, in particular for fixing to vascular wall tissue
EP1057459A1 (en) 1999-06-01 2000-12-06 Numed, Inc. Radially expandable stent
EP1057460A1 (en) 1999-06-01 2000-12-06 Numed, Inc. Replacement valve assembly and method of implanting same
US6241763B1 (en) 1999-06-08 2001-06-05 William J. Drasler In situ venous valve device and method of formation
WO2001005331A1 (en) 1999-07-16 2001-01-25 Biocompatibles Ltd Braided stent
US6371970B1 (en) 1999-07-30 2002-04-16 Incept Llc Vascular filter having articulation region and methods of use in the ascending aorta
US6299637B1 (en) 1999-08-20 2001-10-09 Samuel M. Shaolian Transluminally implantable venous valve
AU3581000A (en) 1999-09-10 2001-04-17 Cook Incorporated Endovascular treatment for chronic venous insufficiency
IT1307268B1 (en) 1999-09-30 2001-10-30 Sorin Biomedica Cardio Spa DEVICE FOR HEART VALVE REPAIR OR REPLACEMENT.
US6371983B1 (en) 1999-10-04 2002-04-16 Ernest Lane Bioprosthetic heart valve
US6352708B1 (en) 1999-10-14 2002-03-05 The International Heart Institute Of Montana Foundation Solution and method for treating autologous tissue for implant operation
US6585758B1 (en) 1999-11-16 2003-07-01 Scimed Life Systems, Inc. Multi-section filamentary endoluminal stent
FR2800984B1 (en) 1999-11-17 2001-12-14 Jacques Seguin DEVICE FOR REPLACING A HEART VALVE PERCUTANEOUSLY
US8579966B2 (en) 1999-11-17 2013-11-12 Medtronic Corevalve Llc Prosthetic valve for transluminal delivery
FR2815844B1 (en) 2000-10-31 2003-01-17 Jacques Seguin TUBULAR SUPPORT FOR THE PERCUTANEOUS POSITIONING OF A REPLACEMENT HEART VALVE
US7300457B2 (en) 1999-11-19 2007-11-27 Advanced Bio Prosthetic Surfaces, Ltd. Self-supporting metallic implantable grafts, compliant implantable medical devices and methods of making same
US6936066B2 (en) 1999-11-19 2005-08-30 Advanced Bio Prosthetic Surfaces, Ltd. Complaint implantable medical devices and methods of making same
US6849085B2 (en) 1999-11-19 2005-02-01 Advanced Bio Prosthetic Surfaces, Ltd. Self-supporting laminated films, structural materials and medical devices manufactured therefrom and method of making same
US6530052B1 (en) 1999-12-29 2003-03-04 Advanced Micro Devices, Inc. Method and apparatus for looping back a current state to resume a memory built-in self-test
US6769434B2 (en) 2000-06-30 2004-08-03 Viacor, Inc. Method and apparatus for performing a procedure on a cardiac valve
DK1255510T5 (en) 2000-01-31 2009-12-21 Cook Biotech Inc Stent Valve Klapper
US7296577B2 (en) 2000-01-31 2007-11-20 Edwards Lifescience Ag Transluminal mitral annuloplasty with active anchoring
US6652571B1 (en) 2000-01-31 2003-11-25 Scimed Life Systems, Inc. Braided, branched, implantable device and processes for manufacture thereof
US6398807B1 (en) 2000-01-31 2002-06-04 Scimed Life Systems, Inc. Braided branching stent, method for treating a lumen therewith, and process for manufacture therefor
US6402781B1 (en) 2000-01-31 2002-06-11 Mitralife Percutaneous mitral annuloplasty and cardiac reinforcement
US6622604B1 (en) 2000-01-31 2003-09-23 Scimed Life Systems, Inc. Process for manufacturing a braided bifurcated stent
US6821297B2 (en) 2000-02-02 2004-11-23 Robert V. Snyders Artificial heart valve, implantation instrument and method therefor
US6797002B2 (en) 2000-02-02 2004-09-28 Paul A. Spence Heart valve repair apparatus and methods
DE10010074B4 (en) * 2000-02-28 2005-04-14 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Device for fastening and anchoring heart valve prostheses
US6468303B1 (en) 2000-03-27 2002-10-22 Aga Medical Corporation Retrievable self expanding shunt
US6454799B1 (en) 2000-04-06 2002-09-24 Edwards Lifesciences Corporation Minimally-invasive heart valves and methods of use
US7686842B2 (en) 2000-05-04 2010-03-30 Oregon Health Sciences University Endovascular stent graft
SE522805C2 (en) 2000-06-22 2004-03-09 Jan Otto Solem Stent Application System
US6527800B1 (en) 2000-06-26 2003-03-04 Rex Medical, L.P. Vascular device and method for valve leaflet apposition
US6419696B1 (en) 2000-07-06 2002-07-16 Paul A. Spence Annuloplasty devices and related heart valve repair methods
WO2002022054A1 (en) 2000-09-12 2002-03-21 Gabbay S Valvular prosthesis and method of using same
US20060142848A1 (en) 2000-09-12 2006-06-29 Shlomo Gabbay Extra-anatomic aortic valve placement
US6461382B1 (en) 2000-09-22 2002-10-08 Edwards Lifesciences Corporation Flexible heart valve having moveable commissures
ATE343969T1 (en) 2000-09-29 2006-11-15 Cordis Corp COATED MEDICAL DEVICES
DE10048814B4 (en) 2000-09-29 2004-04-15 Siemens Ag Computed tomography device with a data acquisition system and method for such a computed tomography device
US6932838B2 (en) 2000-09-29 2005-08-23 Tricardia, Llc Venous valvuloplasty device and method
DE10049815B4 (en) 2000-10-09 2005-10-13 Universitätsklinikum Freiburg Device for local ablation of an aortic valve on the human or animal heart
DE10049813C1 (en) 2000-10-09 2002-04-18 Universitaetsklinikum Freiburg Instrument for the local removal of built-up matter at an aortic valve, in a human or animal heart, is a hollow catheter with a cutting unit at the far end within a closure cap for minimum invasion
DE10049812B4 (en) 2000-10-09 2004-06-03 Universitätsklinikum Freiburg Device for filtering out macroscopic particles from the bloodstream during local removal of an aortic valve on the human or animal heart
DE10049814B4 (en) 2000-10-09 2006-10-19 Universitätsklinikum Freiburg Device for supporting surgical procedures within a vessel, in particular for minimally invasive explantation and implantation of heart valves
WO2002064012A2 (en) 2000-11-07 2002-08-22 Artemis Medical, Inc. Target tissue localization assembly and method
US6482228B1 (en) 2000-11-14 2002-11-19 Troy R. Norred Percutaneous aortic valve replacement
CA2436803C (en) 2000-11-21 2009-09-15 Rex Medical, L.P. Percutaneous aortic valve
US6494909B2 (en) 2000-12-01 2002-12-17 Prodesco, Inc. Endovascular valve
US20020072789A1 (en) 2000-12-12 2002-06-13 Hackett Steven S. Soc lubricant filler port
AU2002236640A1 (en) 2000-12-15 2002-06-24 Viacor, Inc. Apparatus and method for replacing aortic valve
US20040093075A1 (en) 2000-12-15 2004-05-13 Titus Kuehne Stent with valve and method of use thereof
US6562058B2 (en) 2001-03-02 2003-05-13 Jacques Seguin Intravascular filter system
US6488704B1 (en) 2001-05-07 2002-12-03 Biomed Solutions, Llc Implantable particle measuring apparatus
US7374571B2 (en) 2001-03-23 2008-05-20 Edwards Lifesciences Corporation Rolled minimally-invasive heart valves and methods of manufacture
US7556646B2 (en) 2001-09-13 2009-07-07 Edwards Lifesciences Corporation Methods and apparatuses for deploying minimally-invasive heart valves
US6733525B2 (en) 2001-03-23 2004-05-11 Edwards Lifesciences Corporation Rolled minimally-invasive heart valves and methods of use
US6613077B2 (en) 2001-03-27 2003-09-02 Scimed Life Systems, Inc. Stent with controlled expansion
DE10121210B4 (en) 2001-04-30 2005-11-17 Universitätsklinikum Freiburg Anchoring element for the intraluminal anchoring of a heart valve replacement and method for its production
US6663663B2 (en) 2001-05-14 2003-12-16 M.I. Tech Co., Ltd. Stent
KR100393548B1 (en) 2001-06-05 2003-08-02 주식회사 엠아이텍 Stent
US8771302B2 (en) 2001-06-29 2014-07-08 Medtronic, Inc. Method and apparatus for resecting and replacing an aortic valve
US7544206B2 (en) 2001-06-29 2009-06-09 Medtronic, Inc. Method and apparatus for resecting and replacing an aortic valve
US7097659B2 (en) 2001-09-07 2006-08-29 Medtronic, Inc. Fixation band for affixing a prosthetic heart valve to tissue
US20030065386A1 (en) 2001-09-28 2003-04-03 Weadock Kevin Shaun Radially expandable endoprosthesis device with two-stage deployment
US7172572B2 (en) 2001-10-04 2007-02-06 Boston Scientific Scimed, Inc. Manifold system for a medical device
US6976974B2 (en) 2002-10-23 2005-12-20 Scimed Life Systems, Inc. Rotary manifold syringe
GB0125925D0 (en) 2001-10-29 2001-12-19 Univ Glasgow Mitral valve prosthesis
US8308797B2 (en) 2002-01-04 2012-11-13 Colibri Heart Valve, LLC Percutaneously implantable replacement heart valve device and method of making same
US20030130729A1 (en) 2002-01-04 2003-07-10 David Paniagua Percutaneously implantable replacement heart valve device and method of making same
US6730377B2 (en) 2002-01-23 2004-05-04 Scimed Life Systems, Inc. Balloons made from liquid crystal polymer blends
US6752828B2 (en) 2002-04-03 2004-06-22 Scimed Life Systems, Inc. Artificial valve
AU2003228528A1 (en) 2002-04-16 2003-11-03 Viacor, Inc. Method and apparatus for resecting and replacing an aortic valve
US7125418B2 (en) 2002-04-16 2006-10-24 The International Heart Institute Of Montana Foundation Sigmoid valve and method for its percutaneous implantation
US7105016B2 (en) 2002-04-23 2006-09-12 Medtronic Vascular, Inc. Integrated mechanical handle with quick slide mechanism
US20030199971A1 (en) * 2002-04-23 2003-10-23 Numed, Inc. Biological replacement valve assembly
US8721713B2 (en) 2002-04-23 2014-05-13 Medtronic, Inc. System for implanting a replacement valve
US6830575B2 (en) 2002-05-08 2004-12-14 Scimed Life Systems, Inc. Method and device for providing full protection to a stent
US7141064B2 (en) 2002-05-08 2006-11-28 Edwards Lifesciences Corporation Compressed tissue for heart valve leaflets
US20030225445A1 (en) 2002-05-14 2003-12-04 Derus Patricia M. Surgical stent delivery devices and methods
US20040117004A1 (en) 2002-05-16 2004-06-17 Osborne Thomas A. Stent and method of forming a stent with integral barbs
EP1513440A2 (en) 2002-05-30 2005-03-16 The Board of Trustees of The Leland Stanford Junior University Apparatus and method for coronary sinus access
US7959674B2 (en) * 2002-07-16 2011-06-14 Medtronic, Inc. Suture locking assembly and method of use
US7578843B2 (en) 2002-07-16 2009-08-25 Medtronic, Inc. Heart valve prosthesis
DE20321838U1 (en) 2002-08-13 2011-02-10 JenaValve Technology Inc., Wilmington Device for anchoring and aligning heart valve prostheses
US6875231B2 (en) 2002-09-11 2005-04-05 3F Therapeutics, Inc. Percutaneously deliverable heart valve
US7105013B2 (en) 2002-09-30 2006-09-12 Advanced Cardiovascular Systems, Inc. Protective sleeve assembly for a balloon catheter
WO2004037128A1 (en) 2002-10-24 2004-05-06 Boston Scientific Limited Venous valve apparatus and method
EP1567087B1 (en) 2002-11-08 2009-04-01 Jacques Seguin Endoprosthesis for vascular bifurcation
AU2003287638A1 (en) 2002-11-13 2004-06-03 Rosengart, Todd, K. Apparatus and method for cutting a heart valve
US7141061B2 (en) 2002-11-14 2006-11-28 Synecor, Llc Photocurable endoprosthesis system
FR2847155B1 (en) 2002-11-20 2005-08-05 Younes Boudjemline METHOD FOR MANUFACTURING A MEDICAL IMPLANT WITH ADJUSTED STRUCTURE AND IMPLANT OBTAINED THEREBY
WO2004050137A2 (en) 2002-11-29 2004-06-17 Mindguard Ltd. Braided intraluminal device for stroke prevention
US8551162B2 (en) 2002-12-20 2013-10-08 Medtronic, Inc. Biologically implantable prosthesis
US6830585B1 (en) 2003-01-14 2004-12-14 3F Therapeutics, Inc. Percutaneously deliverable heart valve and methods of implantation
US7399315B2 (en) 2003-03-18 2008-07-15 Edwards Lifescience Corporation Minimally-invasive heart valve with cusp positioners
US20060271081A1 (en) 2003-03-30 2006-11-30 Fidel Realyvasquez Apparatus and methods for valve repair
US20050107871A1 (en) 2003-03-30 2005-05-19 Fidel Realyvasquez Apparatus and methods for valve repair
US20040210240A1 (en) 2003-04-21 2004-10-21 Sean Saint Method and repair device for treating mitral valve insufficiency
US7591832B2 (en) 2003-04-24 2009-09-22 Medtronic, Inc. Expandable guide sheath and apparatus with distal protection and methods for use
US20040267357A1 (en) 2003-04-30 2004-12-30 Allen Jeffrey W. Cardiac valve modification method and device
ATE481057T1 (en) 2003-05-28 2010-10-15 Cook Inc VALVE PROSTHESIS WITH VESSEL FIXING DEVICE
WO2005004753A1 (en) 2003-06-09 2005-01-20 3F Therapeutics, Inc. Atrioventricular heart valve and minimally invasive delivery systems thereof
US20040260394A1 (en) 2003-06-20 2004-12-23 Medtronic Vascular, Inc. Cardiac valve annulus compressor system
US20070093869A1 (en) 2003-06-20 2007-04-26 Medtronic Vascular, Inc. Device, system, and method for contracting tissue in a mammalian body
WO2004112651A2 (en) 2003-06-20 2004-12-29 Medtronic Vascular, Inc. Chordae tendinae girdle
EP1648346A4 (en) 2003-06-20 2006-10-18 Medtronic Vascular Inc Valve annulus reduction system
BRPI0412362A (en) 2003-07-08 2006-09-05 Ventor Technologies Ltd prosthetic implant devices particularly for transarterial transport in the treatment of aortic stenoses and implantation methods for such devices
US7201772B2 (en) 2003-07-08 2007-04-10 Ventor Technologies, Ltd. Fluid flow prosthetic device
EP1646332B1 (en) 2003-07-18 2015-06-17 Edwards Lifesciences AG Remotely activated mitral annuloplasty system
DE10334868B4 (en) 2003-07-29 2013-10-17 Pfm Medical Ag Implantable device as a replacement organ valve, its manufacturing process and basic body and membrane element for it
WO2005011535A2 (en) 2003-07-31 2005-02-10 Cook Incorporated Prosthetic valve for implantation in a body vessel
US20050049692A1 (en) 2003-09-02 2005-03-03 Numamoto Michael J. Medical device for reduction of pressure effects of cardiac tricuspid valve regurgitation
US8535344B2 (en) 2003-09-12 2013-09-17 Rubicon Medical, Inc. Methods, systems, and devices for providing embolic protection and removing embolic material
WO2005032421A2 (en) 2003-09-15 2005-04-14 Medtronic Vascular, Inc. Apparatus and method for elongation of a papillary muscle
EG24012A (en) 2003-09-24 2008-03-23 Wael Mohamed Nabil Lotfy Valved balloon stent
JP3726266B2 (en) 2003-10-02 2005-12-14 朝日インテック株式会社 Medical guidewire tip structure
CA2545874C (en) 2003-10-06 2012-02-21 3F Therapeutics, Inc. Minimally invasive valve replacement system
US20060259137A1 (en) * 2003-10-06 2006-11-16 Jason Artof Minimally invasive valve replacement system
US10219899B2 (en) 2004-04-23 2019-03-05 Medtronic 3F Therapeutics, Inc. Cardiac valve replacement systems
US20050075712A1 (en) 2003-10-06 2005-04-07 Brian Biancucci Minimally invasive valve replacement system
US7604650B2 (en) 2003-10-06 2009-10-20 3F Therapeutics, Inc. Method and assembly for distal embolic protection
EP1673041B1 (en) 2003-10-15 2010-04-21 Cook Incorporated Prosthesis deployment system retention device
US7419498B2 (en) 2003-10-21 2008-09-02 Nmt Medical, Inc. Quick release knot attachment system
US7347869B2 (en) 2003-10-31 2008-03-25 Cordis Corporation Implantable valvular prosthesis
US7070616B2 (en) 2003-10-31 2006-07-04 Cordis Corporation Implantable valvular prosthesis
US7655040B2 (en) 2003-11-12 2010-02-02 Medtronic Vascular, Inc. Cardiac valve annulus reduction system
WO2005046530A1 (en) 2003-11-12 2005-05-26 Medtronic Vascular, Inc. Coronary sinus approach for repair of mitral valve reguritation
WO2005048883A1 (en) 2003-11-13 2005-06-02 Fidel Realyvasquez Methods and apparatus for valve repair
US7186265B2 (en) 2003-12-10 2007-03-06 Medtronic, Inc. Prosthetic cardiac valves and systems and methods for implanting thereof
US7261732B2 (en) 2003-12-22 2007-08-28 Henri Justino Stent mounted valve
US9526609B2 (en) 2003-12-23 2016-12-27 Boston Scientific Scimed, Inc. Methods and apparatus for endovascularly replacing a patient's heart valve
US8840663B2 (en) 2003-12-23 2014-09-23 Sadra Medical, Inc. Repositionable heart valve method
US7959666B2 (en) 2003-12-23 2011-06-14 Sadra Medical, Inc. Methods and apparatus for endovascularly replacing a heart valve
US8182528B2 (en) 2003-12-23 2012-05-22 Sadra Medical, Inc. Locking heart valve anchor
US20050137686A1 (en) 2003-12-23 2005-06-23 Sadra Medical, A Delaware Corporation Externally expandable heart valve anchor and method
US20050149181A1 (en) 2004-01-07 2005-07-07 Medtronic, Inc. Bileaflet prosthetic valve and method of manufacture
WO2005069850A2 (en) 2004-01-15 2005-08-04 Macoviak John A Trestle heart valve replacement
US7871435B2 (en) * 2004-01-23 2011-01-18 Edwards Lifesciences Corporation Anatomically approximate prosthetic mitral heart valve
JP4403183B2 (en) 2004-02-05 2010-01-20 チルドレンズ・メディカル・センター・コーポレイション Transcatheter delivery of replacement heart valves
CN101683291A (en) * 2004-02-27 2010-03-31 奥尔特克斯公司 Prosthetic heart valve delivery systems and methods
US20050203549A1 (en) 2004-03-09 2005-09-15 Fidel Realyvasquez Methods and apparatus for off pump aortic valve replacement with a valve prosthesis
WO2005089674A1 (en) 2004-03-15 2005-09-29 Medtronic Vascular Inc. Radially crush-resistant stent
WO2005096993A1 (en) 2004-03-31 2005-10-20 Med Institute, Inc. Endoluminal graft with a prosthetic valve
EP1786367B1 (en) 2004-08-27 2013-04-03 Cook Medical Technologies LLC Placement of multiple intraluminal medical devices within a body vessel
US20060052867A1 (en) 2004-09-07 2006-03-09 Medtronic, Inc Replacement prosthetic heart valve, system and method of implant
FR2874813B1 (en) 2004-09-07 2007-06-22 Perouse Soc Par Actions Simpli VALVULAR PROSTHESIS
US6951571B1 (en) 2004-09-30 2005-10-04 Rohit Srivastava Valve implanting device
US20060089711A1 (en) 2004-10-27 2006-04-27 Medtronic Vascular, Inc. Multifilament anchor for reducing a compass of a lumen or structure in mammalian body
US8562672B2 (en) 2004-11-19 2013-10-22 Medtronic, Inc. Apparatus for treatment of cardiac valves and method of its manufacture
DE102005003632A1 (en) 2005-01-20 2006-08-17 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Catheter for the transvascular implantation of heart valve prostheses
ITTO20050074A1 (en) 2005-02-10 2006-08-11 Sorin Biomedica Cardio Srl CARDIAC VALVE PROSTHESIS
US7955385B2 (en) 2005-02-28 2011-06-07 Medtronic Vascular, Inc. Device, system, and method for aiding valve annuloplasty
US20060195186A1 (en) * 2005-02-28 2006-08-31 Drews Michael J Connectors for two piece heart valves and methods for implanting such heart valves
US7722666B2 (en) * 2005-04-15 2010-05-25 Boston Scientific Scimed, Inc. Valve apparatus, system and method
US7914569B2 (en) 2005-05-13 2011-03-29 Medtronics Corevalve Llc Heart valve prosthesis and methods of manufacture and use
EP3292838A1 (en) 2005-05-24 2018-03-14 Edwards Lifesciences Corporation Rapid deployment prosthetic heart valve
EP3482717B1 (en) 2005-05-27 2023-09-06 Edwards Lifesciences Corporation Stentless support structure
US8663312B2 (en) 2005-05-27 2014-03-04 Hlt, Inc. Intravascular cuff
CA2619587C (en) 2005-08-18 2014-06-10 William A. Cook Australia Pty. Ltd. Assembly of stent grafts
US20080188928A1 (en) 2005-09-16 2008-08-07 Amr Salahieh Medical device delivery sheath
AU2006295080A1 (en) 2005-09-21 2007-04-05 Medtronic, Inc. Composite heart valve apparatus manufactured using techniques involving laser machining of tissue
US20070078510A1 (en) 2005-09-26 2007-04-05 Ryan Timothy R Prosthetic cardiac and venous valves
US8167932B2 (en) 2005-10-18 2012-05-01 Edwards Lifesciences Corporation Heart valve delivery system with valve catheter
DE102005051849B4 (en) 2005-10-28 2010-01-21 JenaValve Technology Inc., Wilmington Device for implantation and attachment of heart valve prostheses
US20070100439A1 (en) 2005-10-31 2007-05-03 Medtronic Vascular, Inc. Chordae tendinae restraining ring
US20070100449A1 (en) 2005-10-31 2007-05-03 O'neil Michael Injectable soft tissue fixation technique
US20070213813A1 (en) 2005-12-22 2007-09-13 Symetis Sa Stent-valves for valve replacement and associated methods and systems for surgery
WO2007081820A1 (en) 2006-01-09 2007-07-19 Children's Medical Center Corporation Transcatheter delivery of a replacement heart valve
US9078781B2 (en) 2006-01-11 2015-07-14 Medtronic, Inc. Sterile cover for compressible stents used in percutaneous device delivery systems
KR100706809B1 (en) 2006-02-07 2007-04-12 삼성전자주식회사 Apparatus for controlling ion beam and method of the same
US20070203391A1 (en) 2006-02-24 2007-08-30 Medtronic Vascular, Inc. System for Treating Mitral Valve Regurgitation
US20070225681A1 (en) 2006-03-21 2007-09-27 Medtronic Vascular Catheter Having a Selectively Formable Distal Section
US20070238979A1 (en) 2006-03-23 2007-10-11 Medtronic Vascular, Inc. Reference Devices for Placement in Heart Structures for Visualization During Heart Valve Procedures
US8075615B2 (en) 2006-03-28 2011-12-13 Medtronic, Inc. Prosthetic cardiac valve formed from pericardium material and methods of making same
US20070232898A1 (en) 2006-03-31 2007-10-04 Medtronic Vascular, Inc. Telescoping Catheter With Electromagnetic Coils for Imaging and Navigation During Cardiac Procedures
US20070233238A1 (en) 2006-03-31 2007-10-04 Medtronic Vascular, Inc. Devices for Imaging and Navigation During Minimally Invasive Non-Bypass Cardiac Procedures
US7625403B2 (en) 2006-04-04 2009-12-01 Medtronic Vascular, Inc. Valved conduit designed for subsequent catheter delivered valve therapy
US7524331B2 (en) 2006-04-06 2009-04-28 Medtronic Vascular, Inc. Catheter delivered valve having a barrier to provide an enhanced seal
US7740655B2 (en) 2006-04-06 2010-06-22 Medtronic Vascular, Inc. Reinforced surgical conduit for implantation of a stented valve therein
US7591848B2 (en) 2006-04-06 2009-09-22 Medtronic Vascular, Inc. Riveted stent valve for percutaneous use
US20070239254A1 (en) 2006-04-07 2007-10-11 Chris Chia System for percutaneous delivery and removal of a prosthetic valve
US20070239269A1 (en) 2006-04-07 2007-10-11 Medtronic Vascular, Inc. Stented Valve Having Dull Struts
US20070244555A1 (en) 2006-04-12 2007-10-18 Medtronic Vascular, Inc. Annuloplasty Device Having a Helical Anchor and Methods for its Use
US7699892B2 (en) 2006-04-12 2010-04-20 Medtronic Vascular, Inc. Minimally invasive procedure for implanting an annuloplasty device
EP3593761A1 (en) 2006-04-12 2020-01-15 Medtronic Vascular, Inc. Annuloplasty device having a helical anchor
US20070244545A1 (en) 2006-04-14 2007-10-18 Medtronic Vascular, Inc. Prosthetic Conduit With Radiopaque Symmetry Indicators
US20070244544A1 (en) 2006-04-14 2007-10-18 Medtronic Vascular, Inc. Seal for Enhanced Stented Valve Fixation
US20070244546A1 (en) 2006-04-18 2007-10-18 Medtronic Vascular, Inc. Stent Foundation for Placement of a Stented Valve
US20070288000A1 (en) 2006-04-19 2007-12-13 Medtronic Vascular, Inc. Method for Aiding Valve Annuloplasty
US7442207B2 (en) 2006-04-21 2008-10-28 Medtronic Vascular, Inc. Device, system, and method for treating cardiac valve regurgitation
US20070255394A1 (en) 2006-04-28 2007-11-01 Medtronic, Inc. Method and apparatus for cardiac valve replacement
JP2009536074A (en) 2006-05-05 2009-10-08 チルドレンズ・メディカル・センター・コーポレイション Transcatheter heart valve
US20080065001A1 (en) 2006-08-23 2008-03-13 Dinucci Kent Portable debridement and irrigation device
WO2008031103A2 (en) 2006-09-08 2008-03-13 Edwards Lifesciences Corporation Integrated heart valve delivery system
US8414643B2 (en) 2006-09-19 2013-04-09 Medtronic Ventor Technologies Ltd. Sinus-engaging valve fixation member
FR2906454B1 (en) 2006-09-28 2009-04-10 Perouse Soc Par Actions Simpli IMPLANT INTENDED TO BE PLACED IN A BLOOD CIRCULATION CONDUIT.
AU2007299934B2 (en) 2006-09-28 2013-09-12 Hlt, Inc. Delivery tool for percutaneous delivery of a prosthesis
WO2008047354A2 (en) 2006-10-16 2008-04-24 Ventor Technologies Ltd. Transapical delivery system with ventriculo-arterial overflow bypass
WO2008070797A2 (en) 2006-12-06 2008-06-12 Medtronic Corevalve, Inc. System and method for transapical delivery of an annulus anchored self-expanding valve
US8070799B2 (en) 2006-12-19 2011-12-06 Sorin Biomedica Cardio S.R.L. Instrument and method for in situ deployment of cardiac valve prostheses
US8470024B2 (en) 2006-12-19 2013-06-25 Sorin Group Italia S.R.L. Device for in situ positioning of cardiac valve prosthesis
US8236045B2 (en) 2006-12-22 2012-08-07 Edwards Lifesciences Corporation Implantable prosthetic valve assembly and method of making the same
EP2111190B1 (en) 2007-01-19 2013-10-09 Medtronic, Inc. Stented heart valve devices for atrioventricular valve replacement
US20080262593A1 (en) 2007-02-15 2008-10-23 Ryan Timothy R Multi-layered stents and methods of implanting
US8623074B2 (en) 2007-02-16 2014-01-07 Medtronic, Inc. Delivery systems and methods of implantation for replacement prosthetic heart valves
FR2913879B1 (en) 2007-03-21 2009-06-12 Perouse Soc Par Actions Simpli DEVICE FOR LAGGING A RADIALLY EXPANSIBLE IMPLANT, NECESSARY FOR TREATMENT AND METHOD OF RELAUNCHING
US20080255651A1 (en) 2007-04-12 2008-10-16 Medtronic Vascular, Inc. Telescoping Stability Sheath and Method of Use
US9138315B2 (en) 2007-04-13 2015-09-22 Jenavalve Technology Gmbh Medical device for treating a heart valve insufficiency or stenosis
US7896915B2 (en) 2007-04-13 2011-03-01 Jenavalve Technology, Inc. Medical device for treating a heart valve insufficiency
BRPI0812372A2 (en) 2007-06-04 2015-02-03 St Jude Medical PROSTHETIC HEART VALVE.
BRPI0813773A2 (en) 2007-06-26 2017-05-16 St Jude Medical apparatus for providing a protein heart valve in a patient.
AU2008294012B2 (en) 2007-08-24 2013-04-18 St. Jude Medical, Inc. Prosthetic aortic heart valves
US8808367B2 (en) 2007-09-07 2014-08-19 Sorin Group Italia S.R.L. Prosthetic valve delivery system including retrograde/antegrade approach
US8114154B2 (en) 2007-09-07 2012-02-14 Sorin Biomedica Cardio S.R.L. Fluid-filled delivery system for in situ deployment of cardiac valve prostheses
BRPI0817708A2 (en) 2007-09-26 2017-05-16 St Jude Medical prosthetic heart valve, and lamella structure for the same.
US9532868B2 (en) 2007-09-28 2017-01-03 St. Jude Medical, Inc. Collapsible-expandable prosthetic heart valves with structures for clamping native tissue
US20090138079A1 (en) 2007-10-10 2009-05-28 Vector Technologies Ltd. Prosthetic heart valve for transfemoral delivery
ATE543461T1 (en) 2007-11-05 2012-02-15 St Jude Medical FOLDABLE AND EXTENDABLE HEART VALVE PROSTHESIS WITH NON-EXTENDABLE STENT COLUMNS AND RECOLLECTION FUNCTION
US20080114452A1 (en) * 2007-11-14 2008-05-15 Shlomo Gabbay Prosthesis exhibiting post-implantation size change
JP5591120B2 (en) 2008-01-16 2014-09-17 セント ジュード メディカル インコーポレイテッド Collapsible / expandable prosthetic heart valve delivery and retrieval system
US9149358B2 (en) 2008-01-24 2015-10-06 Medtronic, Inc. Delivery systems for prosthetic heart valves
US8157853B2 (en) 2008-01-24 2012-04-17 Medtronic, Inc. Delivery systems and methods of implantation for prosthetic heart valves
US9089422B2 (en) 2008-01-24 2015-07-28 Medtronic, Inc. Markers for prosthetic heart valves
US9168130B2 (en) 2008-02-26 2015-10-27 Jenavalve Technology Gmbh Stent for the positioning and anchoring of a valvular prosthesis in an implantation site in the heart of a patient
US8317858B2 (en) 2008-02-26 2012-11-27 Jenavalve Technology, Inc. Stent for the positioning and anchoring of a valvular prosthesis in an implantation site in the heart of a patient
US9044318B2 (en) 2008-02-26 2015-06-02 Jenavalve Technology Gmbh Stent for the positioning and anchoring of a valvular prosthesis
US9011525B2 (en) 2008-02-29 2015-04-21 The Florida International University Board Of Trustees Catheter deliverable artificial multi-leaflet heart valve prosthesis and intravascular delivery system for a catheter deliverable heart valve prosthesis
US8696689B2 (en) 2008-03-18 2014-04-15 Medtronic Ventor Technologies Ltd. Medical suturing device and method for use thereof
US8313525B2 (en) 2008-03-18 2012-11-20 Medtronic Ventor Technologies, Ltd. Valve suturing and implantation procedures
US8137398B2 (en) 2008-10-13 2012-03-20 Medtronic Ventor Technologies Ltd Prosthetic valve having tapered tip when compressed for delivery
US8986361B2 (en) 2008-10-17 2015-03-24 Medtronic Corevalve, Inc. Delivery system for deployment of medical devices
US8998982B2 (en) 2009-01-12 2015-04-07 Valve Medical Ltd. Method and apparatus for fine adjustment of a percutaneous valve structure

Patent Citations (101)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3714671A (en) * 1970-11-30 1973-02-06 Cutter Lab Tissue-type heart valve with a graft support ring or stent
US3868956A (en) * 1972-06-05 1975-03-04 Ralph J Alfidi Vessel implantable appliance and method of implanting it
US4574803A (en) * 1979-01-19 1986-03-11 Karl Storz Tissue cutter
US4501030A (en) * 1981-08-17 1985-02-26 American Hospital Supply Corporation Method of leaflet attachment for prosthetic heart valves
US4647283A (en) * 1982-03-23 1987-03-03 American Hospital Supply Corporation Implantable biological tissue and process for preparation thereof
US4648881A (en) * 1982-03-23 1987-03-10 American Hospital Supply Corporation Implantable biological tissue and process for preparation thereof
US4797901A (en) * 1985-08-22 1989-01-10 Siemens Aktiengesellschaft Circuit arrangement for testing a passive bus network with the carrier sense multiple access with collisions detection method
US4733665A (en) * 1985-11-07 1988-03-29 Expandable Grafts Partnership Expandable intraluminal graft, and method and apparatus for implanting an expandable intraluminal graft
US4733665B1 (en) * 1985-11-07 1994-01-11 Expandable Grafts Partnership Expandable intraluminal graft,and method and apparatus for implanting an expandable intraluminal graft
US4733665C2 (en) * 1985-11-07 2002-01-29 Expandable Grafts Partnership Expandable intraluminal graft and method and apparatus for implanting an expandable intraluminal graft
US5496346A (en) * 1987-01-06 1996-03-05 Advanced Cardiovascular Systems, Inc. Reinforced balloon dilatation catheter with slitted exchange sleeve and method
US4796629A (en) * 1987-06-03 1989-01-10 Joseph Grayzel Stiffened dilation balloon catheter device
US4909252A (en) * 1988-05-26 1990-03-20 The Regents Of The Univ. Of California Perfusion balloon catheter
US4994077A (en) * 1989-04-21 1991-02-19 Dobben Richard L Artificial heart valve for implantation in a blood vessel
US5500014A (en) * 1989-05-31 1996-03-19 Baxter International Inc. Biological valvular prothesis
US5609626A (en) * 1989-05-31 1997-03-11 Baxter International Inc. Stent devices and support/restrictor assemblies for use in conjunction with prosthetic vascular grafts
US4986830A (en) * 1989-09-22 1991-01-22 Schneider (U.S.A.) Inc. Valvuloplasty catheter with balloon which remains stable during inflation
US5089015A (en) * 1989-11-28 1992-02-18 Promedica International Method for implanting unstented xenografts and allografts
US5085635A (en) * 1990-05-18 1992-02-04 Cragg Andrew H Valved-tip angiographic catheter
US5295958A (en) * 1991-04-04 1994-03-22 Shturman Cardiology Systems, Inc. Method and apparatus for in vivo heart valve decalcification
US5397351A (en) * 1991-05-13 1995-03-14 Pavcnik; Dusan Prosthetic valve for percutaneous insertion
US5713953A (en) * 1991-05-24 1998-02-03 Sorin Biomedica Cardio S.P.A. Cardiac valve prosthesis particularly for replacement of the aortic valve
US6029671A (en) * 1991-07-16 2000-02-29 Heartport, Inc. System and methods for performing endovascular procedures
US6338735B1 (en) * 1991-07-16 2002-01-15 John H. Stevens Methods for removing embolic material in blood flowing through a patient's ascending aorta
US5489297A (en) * 1992-01-27 1996-02-06 Duran; Carlos M. G. Bioprosthetic heart valve with absorbable stent
US5876448A (en) * 1992-05-08 1999-03-02 Schneider (Usa) Inc. Esophageal stent
US5480424A (en) * 1993-11-01 1996-01-02 Cox; James L. Heart valve replacement using flexible tubes
US6673109B2 (en) * 1993-11-01 2004-01-06 3F Therapeutics, Inc. Replacement atrioventricular heart valve
US5489294A (en) * 1994-02-01 1996-02-06 Medtronic, Inc. Steroid eluting stitch-in chronic cardiac lead
US5716417A (en) * 1995-06-07 1998-02-10 St. Jude Medical, Inc. Integral supporting structure for bioprosthetic heart valve
US5591195A (en) * 1995-10-30 1997-01-07 Taheri; Syde Apparatus and method for engrafting a blood vessel
US5888201A (en) * 1996-02-08 1999-03-30 Schneider (Usa) Inc Titanium alloy self-expanding stent
US6027525A (en) * 1996-05-23 2000-02-22 Samsung Electronics., Ltd. Flexible self-expandable stent and method for making the same
US5855601A (en) * 1996-06-21 1999-01-05 The Trustees Of Columbia University In The City Of New York Artificial heart valve and method and device for implanting the same
US5861028A (en) * 1996-09-09 1999-01-19 Shelhigh Inc Natural tissue heart valve and stent prosthesis and method for making the same
US6022370A (en) * 1996-10-01 2000-02-08 Numed, Inc. Expandable stent
US20080009940A1 (en) * 1996-12-31 2008-01-10 Alain Cribier Valve prosthesis for implantation in body channels
US20030014104A1 (en) * 1996-12-31 2003-01-16 Alain Cribier Value prosthesis for implantation in body channels
US6171335B1 (en) * 1997-01-24 2001-01-09 Aortech Europe Limited Heart valve prosthesis
US5855597A (en) * 1997-05-07 1999-01-05 Iowa-India Investments Co. Limited Stent valve and stent graft for percutaneous surgery
US20020010508A1 (en) * 1997-11-25 2002-01-24 Chobotov Michael V. Layered endovascular graft
US6042589A (en) * 1998-03-17 2000-03-28 Medicorp, S.A. Reversible-action endoprosthesis delivery device
US6508833B2 (en) * 1998-06-02 2003-01-21 Cook Incorporated Multiple-sided intraluminal medical device
US6692512B2 (en) * 1998-10-13 2004-02-17 Edwards Lifesciences Corporation Percutaneous filtration catheter for valve repair surgery and methods of use
US6350277B1 (en) * 1999-01-15 2002-02-26 Scimed Life Systems, Inc. Stents with temporary retaining bands
US7481838B2 (en) * 1999-01-26 2009-01-27 Edwards Lifesciences Corporation Flexible heart valve and associated connecting band
US20050010285A1 (en) * 1999-01-27 2005-01-13 Lambrecht Gregory H. Cardiac valve procedure methods and devices
US20030040771A1 (en) * 1999-02-01 2003-02-27 Hideki Hyodoh Methods for creating woven devices
US20030040772A1 (en) * 1999-02-01 2003-02-27 Hideki Hyodoh Delivery devices
US6673089B1 (en) * 1999-03-11 2004-01-06 Mindguard Ltd. Implantable stroke treating device
US6348063B1 (en) * 1999-03-11 2002-02-19 Mindguard Ltd. Implantable stroke treating device
US6689164B1 (en) * 1999-10-12 2004-02-10 Jacques Seguin Annuloplasty device for use in minimally invasive procedure
US6685739B2 (en) * 1999-10-21 2004-02-03 Scimed Life Systems, Inc. Implantable prosthetic valve
US20070043435A1 (en) * 1999-11-17 2007-02-22 Jacques Seguin Non-cylindrical prosthetic valve system for transluminal delivery
US7329278B2 (en) * 1999-11-17 2008-02-12 Corevalve, Inc. Prosthetic valve for transluminal delivery
US20030023303A1 (en) * 1999-11-19 2003-01-30 Palmaz Julio C. Valvular prostheses having metal or pseudometallic construction and methods of manufacture
US20030023300A1 (en) * 1999-12-31 2003-01-30 Bailey Steven R. Endoluminal cardiac and venous valve prostheses and methods of manufacture and delivery thereof
US6682559B2 (en) * 2000-01-27 2004-01-27 3F Therapeutics, Inc. Prosthetic heart valve
US20050015112A1 (en) * 2000-01-27 2005-01-20 Cohn William E. Cardiac valve procedure methods and devices
US6989028B2 (en) * 2000-01-31 2006-01-24 Edwards Lifesciences Ag Medical system and method for remodeling an extravascular tissue structure
US20070005129A1 (en) * 2000-02-28 2007-01-04 Christoph Damm Anchoring system for implantable heart valve prostheses
US6676698B2 (en) * 2000-06-26 2004-01-13 Rex Medicol, L.P. Vascular device with valve for approximating vessel wall
US6695878B2 (en) * 2000-06-26 2004-02-24 Rex Medical, L.P. Vascular device for valve leaflet apposition
US20050010246A1 (en) * 2000-06-30 2005-01-13 Streeter Richard B. Intravascular filter with debris entrapment mechanism
US6692513B2 (en) * 2000-06-30 2004-02-17 Viacor, Inc. Intravascular filter with debris entrapment mechanism
US6846325B2 (en) * 2000-09-07 2005-01-25 Viacor, Inc. Fixation band for affixing a prosthetic heart valve to tissue
US20030040792A1 (en) * 2000-09-12 2003-02-27 Shlomo Gabbay Heart valve prosthesis and sutureless implantation of a heart valve prosthesis
US20050010287A1 (en) * 2000-09-20 2005-01-13 Ample Medical, Inc. Devices, systems, and methods for supplementing, repairing, or replacing a native heart valve leaflet
US20030028247A1 (en) * 2001-01-29 2003-02-06 Cali Douglas S. Method of cutting material for use in implantable medical device
US6503272B2 (en) * 2001-03-21 2003-01-07 Cordis Corporation Stent-based venous valves
US6682558B2 (en) * 2001-05-10 2004-01-27 3F Therapeutics, Inc. Delivery system for a stentless valve bioprosthesis
US20050043790A1 (en) * 2001-07-04 2005-02-24 Jacques Seguin Kit enabling a prosthetic valve to be placed in a body enabling a prosthetic valve to be put into place in a duct in the body
US20050033398A1 (en) * 2001-07-31 2005-02-10 Jacques Seguin Assembly for setting a valve prosthesis in a corporeal duct
US20030036791A1 (en) * 2001-08-03 2003-02-20 Bonhoeffer Philipp Implant implantation unit and procedure for implanting the unit
US6986742B2 (en) * 2001-08-21 2006-01-17 Boston Scientific Scimed, Inc. Pressure transducer protection valve
US20080021552A1 (en) * 2001-10-09 2008-01-24 Shlomo Gabbay Apparatus To Facilitate Implantation
US20040039436A1 (en) * 2001-10-11 2004-02-26 Benjamin Spenser Implantable prosthetic valve
US6689144B2 (en) * 2002-02-08 2004-02-10 Scimed Life Systems, Inc. Rapid exchange catheter and methods for delivery of vaso-occlusive devices
US20040034411A1 (en) * 2002-08-16 2004-02-19 Quijano Rodolfo C. Percutaneously delivered heart valve and delivery means thereof
US7335218B2 (en) * 2002-08-28 2008-02-26 Heart Leaflet Technologies, Inc. Delivery device for leaflet valve
US20070027518A1 (en) * 2003-04-01 2007-02-01 Case Brian C Percutaneously deployed vascular valves
US7175656B2 (en) * 2003-04-18 2007-02-13 Alexander Khairkhahan Percutaneous transcatheter heart valve replacement
US6989027B2 (en) * 2003-04-30 2006-01-24 Medtronic Vascular Inc. Percutaneously delivered temporary valve assembly
US20060009841A1 (en) * 2003-05-05 2006-01-12 Rex Medical Percutaneous aortic valve
US7316706B2 (en) * 2003-06-20 2008-01-08 Medtronic Vascular, Inc. Tensioning device, system, and method for treating mitral valve regurgitation
US20070016286A1 (en) * 2003-07-21 2007-01-18 Herrmann Howard C Percutaneous heart valve
US20050027348A1 (en) * 2003-07-31 2005-02-03 Case Brian C. Prosthetic valve devices and methods of making such devices
US6991649B2 (en) * 2003-08-29 2006-01-31 Hans-Hinrich Sievers Artificial heart valve
US20070010878A1 (en) * 2003-11-12 2007-01-11 Medtronic Vascular, Inc. Coronary sinus approach for repair of mitral valve regurgitation
US20060004469A1 (en) * 2004-06-16 2006-01-05 Justin Sokel Tissue prosthesis processing technology
US20060004439A1 (en) * 2004-06-30 2006-01-05 Benjamin Spenser Device and method for assisting in the implantation of a prosthetic valve
US20080015671A1 (en) * 2004-11-19 2008-01-17 Philipp Bonhoeffer Method And Apparatus For Treatment Of Cardiac Valves
US20090012600A1 (en) * 2005-04-05 2009-01-08 Mikolaj Witold Styrc Kit Which Is Intended to Be Implanted in a Blood Vessel, and Associated Tubular Endoprosthesis
US20070005131A1 (en) * 2005-06-13 2007-01-04 Taylor David M Heart valve delivery system
US20070027533A1 (en) * 2005-07-28 2007-02-01 Medtronic Vascular, Inc. Cardiac valve annulus restraining device
US20090048656A1 (en) * 2005-11-09 2009-02-19 Ning Wen Delivery Device for Delivering a Self-Expanding Stent
US20090005863A1 (en) * 2006-02-16 2009-01-01 Goetz Wolfgang Minimally invasive heart valve replacement
US20080004696A1 (en) * 2006-06-29 2008-01-03 Valvexchange Inc. Cardiovascular valve assembly with resizable docking station
US20080048656A1 (en) * 2006-07-14 2008-02-28 Fengshun Tan Thermal controlling method, magnetic field generator and mri apparatus
US20090054976A1 (en) * 2007-08-20 2009-02-26 Yosi Tuval Stent loading tool and method for use thereof
US20100049306A1 (en) * 2008-02-25 2010-02-25 Medtronic Vascular, Inc. Infundibular Reducer Devices

Cited By (54)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10052200B2 (en) 2008-09-19 2018-08-21 Edwards Lifesciences Corporation Surgical heart valves adapted for post implant expansion
US9339377B2 (en) 2008-09-29 2016-05-17 Edwards Lifesciences Cardiaq Llc Body cavity prosthesis
US9456896B2 (en) 2008-09-29 2016-10-04 Edwards Lifesciences Cardiaq Llc Body cavity prosthesis
US9597183B2 (en) 2008-10-01 2017-03-21 Edwards Lifesciences Cardiaq Llc Delivery system for vascular implant
US9585747B2 (en) 2009-04-15 2017-03-07 Edwards Lifesciences Cardiaq Llc Vascular implant
US9333074B2 (en) 2009-04-15 2016-05-10 Edwards Lifesciences Cardiaq Llc Vascular implant and delivery system
US9333073B2 (en) 2009-04-15 2016-05-10 Edwards Lifesciences Cardiaq Llc Vascular implant and delivery method
US9339379B2 (en) 2009-04-15 2016-05-17 Edwards Lifesciences Cardiaq Llc Vascular implant and delivery system
US9339378B2 (en) 2009-04-15 2016-05-17 Edwards Lifesciences Cardiaq Llc Vascular implant and delivery system
US9339380B2 (en) 2009-04-15 2016-05-17 Edwards Lifesciences Cardiaq Llc Vascular implant
US11432924B2 (en) 2010-05-05 2022-09-06 Neovasc Tiara Inc. Transcatheter mitral valve prosthesis
US10449042B2 (en) 2010-05-05 2019-10-22 Neovasc Tiara Inc. Transcatheter mitral valve prosthesis
US11419720B2 (en) 2010-05-05 2022-08-23 Neovasc Tiara Inc. Transcatheter mitral valve prosthesis
US9770329B2 (en) 2010-05-05 2017-09-26 Neovasc Tiara Inc. Transcatheter mitral valve prosthesis
US9554897B2 (en) 2011-04-28 2017-01-31 Neovasc Tiara Inc. Methods and apparatus for engaging a valve prosthesis with tissue
US9713529B2 (en) 2011-04-28 2017-07-25 Neovasc Tiara Inc. Sequentially deployed transcatheter mitral valve prosthesis
JP2022028755A (en) * 2011-11-16 2022-02-16 ダブリュ.エル.ゴア アンド アソシエイツ,インコーポレイティド lattice
JP7335934B2 (en) 2011-11-16 2023-08-30 ダブリュ.エル.ゴア アンド アソシエイツ,インコーポレイティド lattice
US11413139B2 (en) 2011-11-23 2022-08-16 Neovasc Tiara Inc. Sequentially deployed transcatheter mitral valve prosthesis
US10537422B2 (en) 2011-11-23 2020-01-21 Neovasc Tiara Inc. Sequentially deployed transcatheter mitral valve prosthesis
US11497602B2 (en) 2012-02-14 2022-11-15 Neovasc Tiara Inc. Methods and apparatus for engaging a valve prosthesis with tissue
US10363133B2 (en) 2012-02-14 2019-07-30 Neovac Tiara Inc. Methods and apparatus for engaging a valve prosthesis with tissue
US11617650B2 (en) 2012-05-30 2023-04-04 Neovasc Tiara Inc. Methods and apparatus for loading a prosthesis onto a delivery system
US10940001B2 (en) 2012-05-30 2021-03-09 Neovasc Tiara Inc. Methods and apparatus for loading a prosthesis onto a delivery system
US10314705B2 (en) 2012-05-30 2019-06-11 Neovasc Tiara Inc. Methods and apparatus for loading a prosthesis onto a delivery system
US10016275B2 (en) 2012-05-30 2018-07-10 Neovasc Tiara Inc. Methods and apparatus for loading a prosthesis onto a delivery system
US11389294B2 (en) 2012-05-30 2022-07-19 Neovasc Tiara Inc. Methods and apparatus for loading a prosthesis onto a delivery system
EP2938293A4 (en) * 2012-12-31 2017-02-22 Edwards Lifesciences Corporation Post-implant expandable surgical heart valve configurations
US9364322B2 (en) * 2012-12-31 2016-06-14 Edwards Lifesciences Corporation Post-implant expandable surgical heart valve configurations
US10543085B2 (en) 2012-12-31 2020-01-28 Edwards Lifesciences Corporation One-piece heart valve stents adapted for post-implant expansion
CN104884001A (en) * 2012-12-31 2015-09-02 爱德华兹生命科学公司 Post-implant expandable surgical heart valve configurations
US11883282B2 (en) 2012-12-31 2024-01-30 Edwards Lifesciences Corporation Assembly of heart valves and intermediate adapter stent
US11576772B2 (en) 2012-12-31 2023-02-14 Edwards Lifesciences Corporation One-piece heart valve stents adapted for post-implant expansion
JP2016508852A (en) * 2013-03-08 2016-03-24 カーネギー メロン ユニバーシティ Expandable embedded conduit
US10583002B2 (en) 2013-03-11 2020-03-10 Neovasc Tiara Inc. Prosthetic valve with anti-pivoting mechanism
US9681951B2 (en) 2013-03-14 2017-06-20 Edwards Lifesciences Cardiaq Llc Prosthesis with outer skirt and anchors
US9572665B2 (en) 2013-04-04 2017-02-21 Neovasc Tiara Inc. Methods and apparatus for delivering a prosthetic valve to a beating heart
US10383728B2 (en) 2013-04-04 2019-08-20 Neovasc Tiara Inc. Methods and apparatus for delivering a prosthetic valve to a beating heart
US11389291B2 (en) 2013-04-04 2022-07-19 Neovase Tiara Inc. Methods and apparatus for delivering a prosthetic valve to a beating heart
US11911537B2 (en) 2013-12-05 2024-02-27 W. L. Gore & Associates, Inc. Length extensible implantable device and methods for making such devices
US11154394B2 (en) 2014-06-20 2021-10-26 Edwards Lifesciences Corporation Methods of identifying and replacing implanted heart valves
US10130469B2 (en) 2014-06-20 2018-11-20 Edwards Lifesciences Corporation Expandable surgical heart valve indicators
US10098992B2 (en) * 2014-06-30 2018-10-16 Stichting Katholieke Universiteit Heart support device
US20170136162A1 (en) * 2014-06-30 2017-05-18 Stichting Katholieke Universiteit Heart support device
WO2016155730A1 (en) * 2015-04-02 2016-10-06 Hans-Hinrich Sievers Prosthetic heart valve
US11083574B2 (en) 2015-04-02 2021-08-10 Hans-Hinrich Sievers Prosthetic heart valve
USD867594S1 (en) 2015-06-19 2019-11-19 Edwards Lifesciences Corporation Prosthetic heart valve
USD893031S1 (en) 2015-06-19 2020-08-11 Edwards Lifesciences Corporation Prosthetic heart valve
US20200229918A1 (en) * 2017-02-27 2020-07-23 Thuy Pham Novel transcatheter valve replacement device
US11076954B2 (en) * 2017-09-21 2021-08-03 The Cleveland Clinic Foundation Gradually-expandable stent apparatus and method
US20210330457A1 (en) * 2018-03-16 2021-10-28 W. L. Gore & Associates, Inc. Diametric expansion features for prosthetic valves
US11903826B2 (en) * 2018-03-16 2024-02-20 Edwards Lifesciences Corporation Diametric expansion features for prosthetic valves
USD944398S1 (en) 2018-06-13 2022-02-22 Edwards Lifesciences Corporation Expanded heart valve stent
USD979061S1 (en) 2018-06-13 2023-02-21 Edwards Lifesciences Corporation Expanded heart valve stent

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US20140094905A1 (en) 2014-04-03
US8613765B2 (en) 2013-12-24
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WO2009108355A1 (en) 2009-09-03
EP3915525A1 (en) 2021-12-01
US8961593B2 (en) 2015-02-24
US20110264207A1 (en) 2011-10-27
EP2262447A1 (en) 2010-12-22
EP3005984A1 (en) 2016-04-13

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