US20090221717A1 - Magnesium ammonium phosphate cement composition - Google Patents
Magnesium ammonium phosphate cement composition Download PDFInfo
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- US20090221717A1 US20090221717A1 US12/463,880 US46388009A US2009221717A1 US 20090221717 A1 US20090221717 A1 US 20090221717A1 US 46388009 A US46388009 A US 46388009A US 2009221717 A1 US2009221717 A1 US 2009221717A1
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- ammonium phosphate
- phosphate cement
- magnesium ammonium
- cement
- providing
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- C—CHEMISTRY; METALLURGY
- C04—CEMENTS; CONCRETE; ARTIFICIAL STONE; CERAMICS; REFRACTORIES
- C04B—LIME, MAGNESIA; SLAG; CEMENTS; COMPOSITIONS THEREOF, e.g. MORTARS, CONCRETE OR LIKE BUILDING MATERIALS; ARTIFICIAL STONE; CERAMICS; REFRACTORIES; TREATMENT OF NATURAL STONE
- C04B28/00—Compositions of mortars, concrete or artificial stone, containing inorganic binders or the reaction product of an inorganic and an organic binder, e.g. polycarboxylate cements
- C04B28/34—Compositions of mortars, concrete or artificial stone, containing inorganic binders or the reaction product of an inorganic and an organic binder, e.g. polycarboxylate cements containing cold phosphate binders
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/06—Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
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- A61K33/42—Phosphorus; Compounds thereof
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- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A61K6/15—Compositions characterised by their physical properties
- A61K6/17—Particle size
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- A61K6/831—Preparations for artificial teeth, for filling teeth or for capping teeth comprising non-metallic elements or compounds thereof, e.g. carbon
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- A61K6/849—Preparations for artificial teeth, for filling teeth or for capping teeth comprising inorganic cements
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- C04B28/344—Compositions of mortars, concrete or artificial stone, containing inorganic binders or the reaction product of an inorganic and an organic binder, e.g. polycarboxylate cements containing cold phosphate binders the phosphate binder being present in the starting composition solely as one or more phosphates
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- C04B28/34—Compositions of mortars, concrete or artificial stone, containing inorganic binders or the reaction product of an inorganic and an organic binder, e.g. polycarboxylate cements containing cold phosphate binders
- C04B28/346—Compositions of mortars, concrete or artificial stone, containing inorganic binders or the reaction product of an inorganic and an organic binder, e.g. polycarboxylate cements containing cold phosphate binders the phosphate binder being present in the starting composition as a mixture of free acid and one or more phosphates
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- C04B28/00—Compositions of mortars, concrete or artificial stone, containing inorganic binders or the reaction product of an inorganic and an organic binder, e.g. polycarboxylate cements
- C04B28/34—Compositions of mortars, concrete or artificial stone, containing inorganic binders or the reaction product of an inorganic and an organic binder, e.g. polycarboxylate cements containing cold phosphate binders
- C04B28/346—Compositions of mortars, concrete or artificial stone, containing inorganic binders or the reaction product of an inorganic and an organic binder, e.g. polycarboxylate cements containing cold phosphate binders the phosphate binder being present in the starting composition as a mixture of free acid and one or more phosphates
- C04B28/348—Compositions of mortars, concrete or artificial stone, containing inorganic binders or the reaction product of an inorganic and an organic binder, e.g. polycarboxylate cements containing cold phosphate binders the phosphate binder being present in the starting composition as a mixture of free acid and one or more phosphates the starting mixture also containing one or more reactive oxides
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- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
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- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
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Definitions
- the invention relates to a magnesium ammonium phosphate cement preparation, a process for its production and an associated use.
- This invention relates in particular to a biologically degradable cement, which consists in its main phase of magnesium ammonium phosphates and nanoapatites after hardening and thus at the same time has a high strength.
- the material may be used as bone replacement, for bone augmentation and for bone regeneration.
- magnesium has a strong tendency to precipitate in a different structure not similar to apatite.
- Calcium phosphate precipitated physiologically as bone and dentine is nanocrystalline. It cannot be seen from an X-ray diffractogram, due to line broadening, whether it is apatite or other structures.
- Calcium phosphates are not only biocompatible but are recognized by the living cell as belonging-to-the-body. Therefore, there are many biomaterials and medical products which consist partly of calcium phosphate.
- Calcium phosphate ceramics have been on the market since about 1970, partly in the form of prefabricated blocks or as granules.
- Implantations of these materials in bone structures are predominantly successful.
- Calcium phosphate ceramics are most successful when they consist of hydroxyl-apatite (HA) or of beta-tertiary calcium phosphate ( ⁇ -TCP, a whitlockite-like structure) or when the calcium phosphate ceramics consist of both, HA and ⁇ -TCP in variable ratios.
- HA hydroxyl-apatite
- ⁇ -TCP beta-tertiary calcium phosphate
- HA hydroxyl-apatite
- ⁇ -TCP beta-tertiary calcium phosphate
- This phase is not nanocrystalline but microcrystalline.
- calcium phosphate cements based on hydroxylapatite (HA) which are not resorbable (HA ceramics see above) and calcium phosphate cements based on deficient calcium hydroxylapatites (CDHA, calcium deficient hydroxylapatites) which are good osteotransductively, are differentiated.
- CDHA cements which are similar to nanoapatite, which are passively resorbed by the bodily fluids due to the concentration gradients, such as for example monetite (CaHPO 4 ) or calcite (CaCO 3 ) as known from European 0 543 765.
- concentration gradients such as for example monetite (CaHPO 4 ) or calcite (CaCO 3 ) as known from European 0 543 765.
- a cement is also required which can be resorbed completely passively and in which the resorption front and the deposition front are in direct contact.
- Gypsum for example does not fulfill this requirement. Gypsum is resorbed so rapidly that there is always a gaping hole between the resorption front and the deposition front and these materials do not have adequate supporting function due to their low resistance to pressure. Such materials are disclosed, for example under U.S. Pat. No. 5,281,265.
- a bone replacement material which initially takes over the lost supporting function of the bone with high resistance to pressure, but then successively decreases in resistance to pressure, as a result of which the endogenous bone transformation processes (remodeling) are stimulated and hence more rapid osteoneogenesis and hence also active resorption of the bone replacement material is introduced.
- This may also be achieved by incorporating a slightly soluble substance, for example into a hardening cement paste.
- a slightly soluble substance for example into a hardening cement paste.
- solubilizing substances consisting of, for example sugars, salts (for example NaCl) or gypsum (CaSO 4 ) into the cement paste. They are then leached out very rapidly in the body from the hardened cement structure and a porous sponge-like structure remains. Production of a porous (finished) cement outside the body is also conceivable.
- a cement for dental applications, such as for example filling and sealing of small dentine channels, filling of tooth cavities after vital extirpation, utilizing such a cement as sub-filling material in endodontology, such a material may not shrink to prevent passage of bacteria. Even a material having low-grade expandable properties would be desirable.
- the present invention provides a magnesium ammonium phosphate cement preparation, comprising: a powder mixture having molar quantities of the components calcium (Ca), magnesium (Mg) and orthophosphate (P) in the mixture in the ranges 1.00 ⁇ Ca/P ⁇ 1.50 and 0 ⁇ Mg/P ⁇ 0.50; an ammonium salt; and water and/or an aqueous solution.
- the present invention provides a magnesium ammonium phosphate cement preparation, comprising: a powder mixture, consisting of ( ⁇ -TCP, ⁇ -TCP, MgHPO 4 ⁇ 3H 2 O, KH 2 PO 4 and Na 2 HPO 4 ; an ammonium salt; and water and/or an aqueous solution.
- the present invention provides a magnesium ammonium phosphate cement preparation, comprising: a powder mixture consisting of: ⁇ / ⁇ -TCP, MgHPO 4 ⁇ 3H 2 O, KH 2 PO 4 Na 2 HPO 4 and Mg 3 (PO 4 ) 2 ; and an aqueous solution containing ammonium ions.
- the present invention provides a magnesium ammonium phosphate cement preparation, comprising: a powder mixture consisting of: ⁇ / ⁇ -TCP, MgHPO 4 ⁇ 3H 2 O, KH 2 PO 4 Na 2 HPO 4 and Mg 3 (PO 4 ) 2 ; and an aqueous solution containing ammonium ions.
- the present invention provides a magnesium ammonium phosphate cement preparation, comprising: a powder mixture consisting of: ⁇ / ⁇ -TCP, MgHPO 4 ⁇ 3H 2 O, KH 2 PO 4 Na 2 HPO 4 and Mg 3 (PO 4 ) 2 ; and an aqueous solution containing ammonium ions.
- the preparations of the present invention can also include one or more of the following features:
- the invention also provides a process for producing a magnesium ammonium phosphate cement wherein the powder mixture is mixed with the mixing liquid while achieving uniform distribution of the liquid in the powder mixture and the paste thus obtained is applied on or to the target zone or is introduced into the target zone and is allowed to harden, wherein the components react such that the cement formed has microcrystalline magnesium ammonium phosphate.
- the invention provides a process for producing a magnesium ammonium phosphate cement using a magnesium ammonium cement preparation, in which the powder mixture is mixed with the mixing liquid while achieving uniform distribution of the liquid in the powder mixture and the paste thus obtained is applied on or to the target zone or is introduced into the target zone and is allowed to harden with formation of cement containing microcrystalline magnesium ammonium phosphate.
- the process in accord with the present invention also can include one or more of the following features:
- preparations of the present invention can be used, e.g., for medical purposes, for tooth cement and for bone replacement or bone filler or bone cement or bone adhesive.
- the problems in the state of the art are preferably solved by the present invention to the effect that it is possible to set the ability for expansion of the hardening cement paste by variation in the admixture of strontium salts.
- the ability for expansion of the cement mixture the main phase of which is the magnesium ammonium phosphate in the hardened state, decreases with increasing weight portion of strontium salts in the total powder mixture. Consequently, with this invention a material for endodontology may be provided, which also has an expandable property in addition to adequate mechanically loadable stability.
- An object of this invention is to provide a material for bone replacement, for bone augmentation and bone regeneration, which may be resorbed in a limited time and the resistance to pressure of which may decrease adapted to the regeneration requirements of the body.
- Another object of the invention to provide a material that may be created, prepared and modeled under normal temperature conditions, preferably body temperature, in other words a cement.
- the material provided may additionally be adjusted by the intensity of the degree of sintering of the Mg 3 (PO 4 ) 2 introduced in its processing time, in particular at room temperature, wherein the rate of solubility on the surface of these particles is controlled by the degree of sintering and the density of the Mg 3 (PO 4 ) 2 used resulting therefrom, so that the precipitation of the Ca/Mg/phosphate compound settling out necessary for solidification may be controlled.
- a phosphate cement having partial solubility, preferably due to the slow solubility of the magnesium ammonium phosphate apatite structure (cement).
- the object of the invention is the material disclosed according to the invention which is characterized by a strong ability for adhesion to metallic surfaces.
- the end product consists of a powder mixture having a molar Ca/P ratio in the range from 1.00 to 1.50.
- P represents orthophosphate
- the molar ratio Mg/P ratio of this powder mixture includes the range from 0 to 1.00.
- a further aspect of this invention is to mix the powder mixtures with suitable quantities of slightly basic (7 ⁇ pH ⁇ 12), aqueous solutions of soluble ionic constituents, such as for example: Na 3 PO 4 , K 2 CO 3 and/or Na 2 CO 3 in combination with (NH 4 ) 2 HPO 4 .
- a further feature of this invention is that granular but granular solids which are thus slightly soluble in the bodily fluid are admixed to the hardening cement paste, so that after settling-out thereof, a microporous to macroporous pore system results.
- a further aspect of this invention is that these cements reach their maximum solidity within a few hours.
- a further feature of this invention lies in the ability for expansion of the cement during setting.
- the expansivity is determined or adjusted by the relative proportion of an admixed strontium salt.
- a further feature of this invention is that the hardened cement consists of microcrystalline magnesium ammonium phosphate.
- a further feature of this invention is that the initial hardening time of the cement may be set at 1 to 40 minutes and the final hardening time at 2.5 to 60 minutes. (according to ASTM C266-89)
- a further feature of this invention is that the cement may reach a maximum compressive strength of over 50 MPa.
- a further feature of this invention is that the cement paste can be injected before reaching the initial hardening time.
- cement paste may serve as excipient for other materials which are not Ca, Mg and/or phosphate.
- materials which are not Ca, Mg and/or phosphate.
- ZnO pharmaceutical active ingredients (antibiotics, cytostatic agents, growth factors) or other bioactive substances.
Abstract
This invention relates to a cement, which comprises in its main phase of microcrystalline magnesium ammonium phosphate and nanoapatite after hardening and thus at the same time has considerable strength. The material is biologically degradable and is suitable for application in tooth cements, as bone replacement, as bone filler, as bone cement or as bone adhesive.
Description
- This application is a continuation of application Ser. No. 11/530,835, filed Sep. 11, 2006, which is a continuation of application Ser. No. 11/104,392, filed Apr. 11, 2005, which is a continuation of application Ser. No. 10/772,857, filed on Feb. 4, 2004, now U.S. Pat. No. 6,908,506 which is a continuation of application Ser. No. 10/070,670, filed on Mar. 4, 2002, now U.S. Pat. No. 6,692,563, which was a § 371 National Phase of PCT/EP01/07605, filed on Jul. 3, 2001, which claimed priority from DE 100 32 220, filed on Jul. 3, 2000, the full disclosures of which are incorporated herein by reference.
- The invention relates to a magnesium ammonium phosphate cement preparation, a process for its production and an associated use.
- This invention relates in particular to a biologically degradable cement, which consists in its main phase of magnesium ammonium phosphates and nanoapatites after hardening and thus at the same time has a high strength.
- The material may be used as bone replacement, for bone augmentation and for bone regeneration.
- It may serve as excipient for pharmaceutical or biological active ingredients.
- The most important mineral constituents in human bone and tooth enamel are calcium and phosphate. However, considerable quantities of sodium, magnesium and carbonate are also present.
- It is known from precipitation studies of synthetic systems that sodium ions and carbonate ions may be incorporated very easily into calcium phosphate precipitates resulting in a molecular structure similar to apatite.
- However, magnesium has a strong tendency to precipitate in a different structure not similar to apatite.
- Calcium phosphate precipitated physiologically as bone and dentine is nanocrystalline. It cannot be seen from an X-ray diffractogram, due to line broadening, whether it is apatite or other structures.
- Some scientists are of the opinion that so much magnesium occurs in bone and dentine that this cannot all be taken up in the apatite structure. Therefore, a mixed form of the mineral of nanoapatite and nanodolomite or nanostruvite is assumed here.
- Calcium phosphates are not only biocompatible but are recognized by the living cell as belonging-to-the-body. Therefore, there are many biomaterials and medical products which consist partly of calcium phosphate.
- Calcium phosphate ceramics have been on the market since about 1970, partly in the form of prefabricated blocks or as granules.
- Implantations of these materials in bone structures are predominantly successful.
- The biggest disadvantage of these systems is that the blocks have to be prefabricated and the granules drift away (flood out) from the side of the implantation. This often leads to failure of such implantations.
- Calcium phosphate ceramics are most successful when they consist of hydroxyl-apatite (HA) or of beta-tertiary calcium phosphate (β-TCP, a whitlockite-like structure) or when the calcium phosphate ceramics consist of both, HA and β-TCP in variable ratios. HA is virtually non-resorbable from bone implantations, whereas β-TCP is slowly resorbed and replaced by new bone.
- It is therefore possible to influence the degree of resorption of calcium phosphate ceramic by changing the β-TCP/HA ratio.
- It is likewise possible to admix other resorbable materials, such as: monetite CaHPO4, brushite CaHPO4-2H2O, calcite CaCO3 and dolomite CaMg(CO3)2.
- Since 1985 attempts have been made to develop calcium phosphate cements in order to avoid the disadvantages of prefabricated or granular-like calcium phosphate ceramics (W. E. Brown and L. C. Chow, “A new calcium phosphate, water-setting cement”, Cem. Res. Prog. 1986 352-379 (1987)).
- This includes a brushite cement not yet commercially available having a Ca/P molar ratio of the precipitated phase of 1.00. This phase is not nanocrystalline but microcrystalline.
- All the other calcium phosphate cements developed hitherto have a nanocrystalline precipitation structure and a Ca/P molar ratio of >=1.5, which may be further increased by addition of carbonate. These materials are known under U.S. Pat. No. 5,605,713; European application 0 835 668; World 96/14265, and some of these materials are already on the market.
- There are contradictory reports regarding the resorbability of these materials after implantations in bone and soft tissue.
- In each case, calcium phosphate cements based on hydroxylapatite (HA) which are not resorbable (HA ceramics see above) and calcium phosphate cements based on deficient calcium hydroxylapatites (CDHA, calcium deficient hydroxylapatites) which are good osteotransductively, are differentiated.
- This means for the last-mentioned case, that they may be resorbed by osteoclasts and may be replaced by new bone tissue from osteoblasts.
- Resorption of these cements depends crucially on the local bone transformation mechanisms.
- Today, most surgeons require a calcium phosphate cement, in which initially a mechanically supporting mode of action is brought to bear, but the final resorption lags behind independently of the local transformation mechanisms of the bone, that is that the material is completely degraded. In addition, it is known in orthopaedics that vital bone only remains where it is required from the biomechanical point of view. This is known as the so-called Wolffs Law. Consequently, if a calcium phosphate cement introduced into a bone defect has a higher compressive strength than the bone surrounding it and this high compressive strength remains unchanged, this leads to degradation of bone tissue lying around the implant (here calcium phosphate cement).
- In order to fulfill this requirement, even if only partly, some manufacturers have admixed substances into their CDHA cements which are similar to nanoapatite, which are passively resorbed by the bodily fluids due to the concentration gradients, such as for example monetite (CaHPO4) or calcite (CaCO3) as known from European 0 543 765.
- However, this only partly solves the problem. A cement is also required which can be resorbed completely passively and in which the resorption front and the deposition front are in direct contact.
- Gypsum for example does not fulfill this requirement. Gypsum is resorbed so rapidly that there is always a gaping hole between the resorption front and the deposition front and these materials do not have adequate supporting function due to their low resistance to pressure. Such materials are disclosed, for example under U.S. Pat. No. 5,281,265.
- For these reasons, it is desirable to provide a bone replacement material, which initially takes over the lost supporting function of the bone with high resistance to pressure, but then successively decreases in resistance to pressure, as a result of which the endogenous bone transformation processes (remodeling) are stimulated and hence more rapid osteoneogenesis and hence also active resorption of the bone replacement material is introduced. This may also be achieved by incorporating a slightly soluble substance, for example into a hardening cement paste. Because bone grows well into macroporous structures, it is advantageous to admix granular or pellet-like, solubilizing substances consisting of, for example sugars, salts (for example NaCl) or gypsum (CaSO4) into the cement paste. They are then leached out very rapidly in the body from the hardened cement structure and a porous sponge-like structure remains. Production of a porous (finished) cement outside the body is also conceivable.
- In order to be able to use a cement for dental applications, such as for example filling and sealing of small dentine channels, filling of tooth cavities after vital extirpation, utilizing such a cement as sub-filling material in endodontology, such a material may not shrink to prevent passage of bacteria. Even a material having low-grade expandable properties would be desirable.
- It is the object of the invention to provide a cement preparation, with which the disadvantages of the state of the art are avoided.
- The present invention provides a magnesium ammonium phosphate cement preparation, comprising: a powder mixture having molar quantities of the components calcium (Ca), magnesium (Mg) and orthophosphate (P) in the mixture in the ranges 1.00<Ca/P<1.50 and 0<Mg/P<0.50; an ammonium salt; and water and/or an aqueous solution.
- In one embodiment, the present invention provides a magnesium ammonium phosphate cement preparation, comprising: a powder mixture, consisting of (α-TCP, β-TCP, MgHPO4×3H2O, KH2PO4 and Na2HPO4; an ammonium salt; and water and/or an aqueous solution.
- In another embodiment, the present invention provides a magnesium ammonium phosphate cement preparation, comprising: a powder mixture consisting of: α/β-TCP, MgHPO4×3H2O, KH2PO4 Na2HPO4 and Mg3(PO4)2; and an aqueous solution containing ammonium ions.
- In a further embodiment, the present invention provides a magnesium ammonium phosphate cement preparation, comprising: a powder mixture consisting of: α/β-TCP, MgHPO4×3H2O, KH2PO4 Na2HPO4 and Mg3(PO4)2; and an aqueous solution containing ammonium ions.
- In yet another embodiment, the present invention provides a magnesium ammonium phosphate cement preparation, comprising: a powder mixture consisting of: α/β-TCP, MgHPO4×3H2O, KH2PO4 Na2HPO4 and Mg3(PO4)2; and an aqueous solution containing ammonium ions.
- The preparations of the present invention can also include one or more of the following features:
-
- the aqueous solution is an aqueous solution of an ammonium salt having a pH value in the range from 7<pH<12;
- the ammonium salt is present in the powder mixture and the molar quantities of the components calcium (Ca), magnesium (Mg), orthophosphate (P) and ammonium (NH4) lie in the ranges 1.00<Ca/P<1.50 and 0<Mg/P<0.50 and 0<NH4<0.50;
- the powder mixture comprises α/β-tertiary calcium phosphate (α/β-TCP) and preferably MgHPO4×3H2O;
- the powder mixture, apart from α/β-TCP and MgHPO4×3H2O, additionally contains Mg3(P04)2;
- the aqueous solution comprises an aqueous (NH4)2SO4 solution;
- the powder mixture comprises (NH4)2SO4;
- a mixing liquid consists of an aqueous (NH4)2HPO4 solution;
- the powder mixture additionally comprises KH2PO4;
- the powder mixture additionally comprises Na2HPO4;
- additionally SrCO3;
- the level of SrCO3 is 0.01 to 10 wt. %, preferably 0.1 to 5 wt. %, based on the total weight of the preparation;
- an aqueous solution of an ammonium salt as mixing liquid;
- an aqueous solution of a magnesium salt as mixing liquid;
- as additional component, ZnO in the powder mixture and/or in the mixing liquid;
- the powder mixture additionally contains Ca2NaK(PO4)2 and/or CaKPO4;
- as an additional component, fluoride ions in the powder mixture and/or in the mixing liquid; and
- as additional components, pharmaceutical and/or bioactive active ingredients in the powder mixture and/or in the mixing liquid, preferably antibiotics, cytostatic agents, analgesics, disinfectants, growth factors, proteins or elastin inhibitors in therapeutic doses.
- The invention also provides a process for producing a magnesium ammonium phosphate cement wherein the powder mixture is mixed with the mixing liquid while achieving uniform distribution of the liquid in the powder mixture and the paste thus obtained is applied on or to the target zone or is introduced into the target zone and is allowed to harden, wherein the components react such that the cement formed has microcrystalline magnesium ammonium phosphate.
- In another embodiment, the invention provides a process for producing a magnesium ammonium phosphate cement using a magnesium ammonium cement preparation, in which the powder mixture is mixed with the mixing liquid while achieving uniform distribution of the liquid in the powder mixture and the paste thus obtained is applied on or to the target zone or is introduced into the target zone and is allowed to harden with formation of cement containing microcrystalline magnesium ammonium phosphate.
- The process in accord with the present invention also can include one or more of the following features:
-
- granular, thus granular particles which are slightly soluble in aqueous liquids, between about 10 μm and about 300 μm, preferably between 50 μm and 200 μm, are added to the powder mixture; and
- the granular particles preferably consist of NaCl, sugars, CaSO4, β-TCP, polylactides, polyglycolides or polylactide/polyglycolide copolymer, CaCO3CaHPO4.
- The preparations of the present invention can be used, e.g., for medical purposes, for tooth cement and for bone replacement or bone filler or bone cement or bone adhesive.
- The problems in the state of the art are preferably solved by the present invention to the effect that it is possible to set the ability for expansion of the hardening cement paste by variation in the admixture of strontium salts. In tests, as shown in the examples, it is namely shown that the ability for expansion of the cement mixture, the main phase of which is the magnesium ammonium phosphate in the hardened state, decreases with increasing weight portion of strontium salts in the total powder mixture. Consequently, with this invention a material for endodontology may be provided, which also has an expandable property in addition to adequate mechanically loadable stability.
- An object of this invention is to provide a material for bone replacement, for bone augmentation and bone regeneration, which may be resorbed in a limited time and the resistance to pressure of which may decrease adapted to the regeneration requirements of the body.
- Another object of the invention to provide a material that may be created, prepared and modeled under normal temperature conditions, preferably body temperature, in other words a cement.
- It is characteristic of the material provided, that it may additionally be adjusted by the intensity of the degree of sintering of the Mg3(PO4)2 introduced in its processing time, in particular at room temperature, wherein the rate of solubility on the surface of these particles is controlled by the degree of sintering and the density of the Mg3(PO4)2 used resulting therefrom, so that the precipitation of the Ca/Mg/phosphate compound settling out necessary for solidification may be controlled.
- Furthermore, it is the object of this invention to provide a phosphate cement having partial solubility, preferably due to the slow solubility of the magnesium ammonium phosphate apatite structure (cement).
- Furthermore, it is the object of the present invention to describe a reaction process, which leads to the formation of a magnesium ammonium phosphate cement from a number of individual components and which hardens in a clinically acceptable time at room and/or body temperature.
- Furthermore, it is the object of the present invention to provide a material which becomes adequately hard and stable in a clinically acceptable time and which has a strong ability for adhesion to mineralized surfaces.
- Furthermore, the object of the invention is the material disclosed according to the invention which is characterized by a strong ability for adhesion to metallic surfaces.
- Furthermore, it is the object of the present invention to provide a resorbable cement, which can be injected in the form of a mixed paste.
- One aspect of this invention is that the end product consists of a powder mixture having a molar Ca/P ratio in the range from 1.00 to 1.50. (P represents orthophosphate).
- In addition, it is essential that the molar ratio Mg/P ratio of this powder mixture includes the range from 0 to 1.00.
- In order to mix and to shape a cement paste, which hardens within an acceptable time, these powder mixtures must be adequately reactive. In order to achieve this, a further aspect of this invention is to mix the powder mixtures with suitable quantities of slightly basic (7<pH<12), aqueous solutions of soluble ionic constituents, such as for example: Na3PO4, K2CO3 and/or Na2CO3 in combination with (NH4)2HPO4.
- A further feature of this invention is that granular but granular solids which are thus slightly soluble in the bodily fluid are admixed to the hardening cement paste, so that after settling-out thereof, a microporous to macroporous pore system results.
- A further aspect of this invention is that these cements reach their maximum solidity within a few hours.
- A further feature of this invention lies in the ability for expansion of the cement during setting. The expansivity is determined or adjusted by the relative proportion of an admixed strontium salt.
- A further feature of this invention is that the hardened cement consists of microcrystalline magnesium ammonium phosphate.
- A further feature of this invention is that the initial hardening time of the cement may be set at 1 to 40 minutes and the final hardening time at 2.5 to 60 minutes. (according to ASTM C266-89)
- A further feature of this invention is that the cement may reach a maximum compressive strength of over 50 MPa.
- A further feature of this invention is that the cement paste can be injected before reaching the initial hardening time.
- A further feature of this invention is that the cement paste may serve as excipient for other materials which are not Ca, Mg and/or phosphate. For example ZnO, pharmaceutical active ingredients (antibiotics, cytostatic agents, growth factors) or other bioactive substances.
- Further features and advantages of the invention can be seen from the description of exemplary embodiments.
- The following symbols are used in the examples:
- P=powder mixture
- L=liquid
- UP=liquid/powder ratio in ml/g
- ti=initial hardening time (according to ASTM standard C266-89, Gilmoore needle)
- tF=final (end) hardening time (according to ASTM standard C266-89, Gilmoore needle)
- D(x h)=compressive strength in Mpa after x hours storage in 0.9% strength NaCl solution at 37° C.
- Production: After weighing out all constituents, the powder mixture is homogenized in a ball mill for about 20 minutes.
-
-
P= 60 g α-Ca3(PO4)2 + 6 g MgHPO4•3H2O + 5 g MgSO4•7H2O L= 2M (NH4)2HPO4 L/P= 0.40 ti= 9 TF= 21 D(18) 18.4 ± 1.5 D(72) 26.1 ± 4.0 -
-
P= 60 g α-Ca3(PO4)2 + 14 g MgHPO4•3H2O + 2 g Mg(OH)2 L= 3.5 M (NH4)2HPO4 L/P= 0.35 ti= 3 TF= 7 D(18) 32.5 ± 3.5 D(72) 46.9 ± 5.4 -
-
P= 60 g α-Ca3(PO4)2 + 16 g MgHPO4•3H2O + 3 g Na(PO4)3•12H2O L= 3.5 M (NH4)2HPO4 L/P= 0.35 ti= 6 TF= 14 D(18) 44.7 ± 3.4 D(72) 51.7 ± 5.0 -
-
P= 60 g α-Ca3(PO4)2 + 14 g MgHPO4•3H2O + 2 g ZnO L= 3.5 M (NH4)2HPO4 L/P= 0.35 ti= 6 TF= 23 D(18) 35.1 ± 5.3 D(72) 42.9 ± 0.8 -
-
P= 45 g CaHPO4•2 H2O + 14 g MgHPO4•3H2O + 6 g Mg(OH)2 L= 2 M (NH4)2HPO4 L/P= 0.40 ti= 2.5 TF= 7.5 D(18) 3.8 ± 1.2 -
-
P= 45 g CaHPO4•2 H2O + 14 g CaCO3 + 14 g MgHPO4•3H2O + 6 g ZnO L= 3.5 M (NH4)2HPO4 L/P= 0.35 ti= 2 TF= 4 D(18) 3.8 ± 1.2 -
-
P= 60 g α-Ca3(PO4)2 + 16 g MgHPO4•3H2O + 5 g β-Ca3(PO4)2 L= 3.5 M (NH4)2HPO4 L/P= 0.35 ti= 4 TF= 9 D(2) 59.3 ± 1.0 D(4) 55.6 ± 5.0 D(18) 61.6 ± 5.0 D(72) 51.5 ± 6.6 D(18d) 28.1 ± 4.6 -
-
P= 60 g α-Ca3(PO4)2 + 16 g MgHPO4•3H2O + 5 g β-Ca3(PO4)2 L= 3.5 M (NH4)2HPO4 L/P= 0.35 ti= 3.5 TF= 11.5 D(2) 54.4 ± 3.3 D(18) 65.6 ± 5.3 D(4d) 56.6 ± 8.6 D(18d) 36.3 ± 2.4 D(30d) 30.0 ± 3.0 -
-
P= 60 g α-Ca3(PO4)2 + 16 g MgHPO4•3H2O + 5 g β- Ca3(PO4)2 + 0.8 g SrCO3 L= 3.5 M (NH4)2HPO4 L/P= 0.35 ti= 5.5 TF= 13 D(2.5) 54.3 ± 4.6 D(5) 61.1 ± 5.5 D(18) 70.1 ± 5.7 D(4d) 74.3 ± 9.3 D(18d) 43.4 ± 3.4 D(30d) 34.0 ± 4.0 -
-
P= 60 g α-Ca3(PO4)2 + 8 g MgHPO4•3H2O + 2 g (NH4)2SO4 + 2 g KH2PO4 + 3.5 g SrCO3 L= 3.5 M (NH4)2HPO4 L/P= 0.30 ti= TF= D(0.25) 11.2 ± 0.8 D(0.5) 17.2 ± 1.8 D(2) 31.7 ± 1.3 D(6) 39.7 ± 0.63 D(3d) 56.5 ± 4.9 -
-
P= 60 g α-Ca3(PO4)2 + 8 g MgHPO4•3H2O + 4 g (NH4)H2PO4 + 1 g SrCO3 L= 3.5 M (NH4)2HPO4 L/P= 0.37 ti= TF= D(2) 22.6 ± 1.0 D(6) 31.4 ± 1.1 D(18) 45.8 ± 1.8 D(3d) 45.7 ± 2.9 D(35d) 11.5 ± 1.2 -
-
P= 60 g α-Ca3(PO4)2 + 17.4 g MgHPO4•3H2O + 7 g (NH4)2SO4 + 1.7 g SrCO3 L= 3.5 M (NH4)2HPO4 L/P= 0.35 ti= TF= D(2) 43.3 ± 2.9 D(6) 45.4 ± 4.4 D(18) 45.8 ± 1.8 D(3d) 45.7 ± 2.9 D(28d) 19.5 ± 5.1 -
-
P= 60 g α-Ca3(PO4)2 + 20 g CaHPO4 + 8 g CaCO3 + 1 g MgHPO4 + 1.7 g SrCO3 L= 3.5 M (NH4)2HPO4 L/P= 0.35 ti= 2.5 TF= 8 D(2) 43.3 ± 2.9 D(6) 49.4 ± 3.7 D(18) 54.3 ± 2.5 D(3d) 53.6 ± 3.1 D(28d) 54.5 ± 1.9 -
-
P= 60 g β-Ca3(PO4)2 + 17.4 g MgHPO4•3H2O + 1.7 g SrCO3 L= 3.5 M (NH4)2HPO4 L/P= 0.35 ti= 3.5 TF= 9 -
-
P= 60 g α-TCP + 34.8 g MgHPO4 × 3H2O + 13.2 g (NH4)SO4 L= 5% NaHCO3 L/P= 0.35 ti= 3 TF= 10 -
-
P= 60 g α-TCP + 16 g MgHPO4 × 3H2O + 5 g β-TCP + 20 g NaCL (diameter 150 μm) L= 3.5 M (NH4)2HPO4 L/P= 0.35 ti= 5 TF= 12 - Mixing solution: 3.2 molar solution (NH4)2HPO4
- Ti=10.8 tf=20
- While the above is a complete description of the preferred embodiments of the invention, various alternatives, modifications, and equivalents may be used. Therefore, the above description should not be taken as limiting the scope of the invention which is defined by the appended claims.
Claims (14)
1-44. (canceled)
45. A magnesium ammonium phosphate cement produced by a process comprising:
providing an ammonium salt;
providing a powder mixture having molar quantities of the components calcium (Ca), magnesium (Mg) and orthophosphate (P) in the mixture in the ranges 1.00<Ca/P<1.50 and 0<Mg/P<0.50;
mixing the ammonium salt and the powder mixture with a mixing liquid to form a paste and achieve an uniform distribution of the liquid in the powder mixture; and
reacting the components therein to form a microcrystalline magnesium ammonium phosphate cement.
46. The magnesium ammonium phosphate cement of claim 45 , further comprising providing a strontium salt.
47. The magnesium ammonium phosphate cement of claim 46 , wherein the strontium salt comprises SrCO3.
48. The magnesium ammonium phosphate cement of claim 47 , comprising providing the SrCO3 in a quantity of 0.01 to 10 wt. % based on the total weight of the preparation.
49. The magnesium ammonium phosphate cement of claim 45 , comprising providing the ammonium salt as (NH4)2HPO4.
50. The magnesium ammonium phosphate cement of claim 45 , comprising reacting the components therein between about 2.5 to about 60 minutes (measured according to ASTM C266-89) to form the magnesium ammonium phosphate cement.
51. The magnesium ammonium phosphate cement of claim 45 , further comprising providing granular particles.
52. The magnesium ammonium phosphate cement of claim 51 , wherein the granular particles are slightly soluble in aqueous liquids.
53. The preparation of claim 51 , comprising providing granular particles having a diameter of between 10 μm and 300 μm.
54. The magnesium ammonium phosphate cement of claim 51 , wherein the granular particles are a substance selected from the group consisting of NaCl, sugars, CaSO4, β-TCP, polylactides, polyglycolides or polylactide/polyglycolide copolymer, CaCO3 and CaHPO4.
55. The magnesium ammonium phosphate cement of claim 45 , further comprising adding a pharmaceutical and/or a bioactive active ingredient.
56. The magnesium ammonium phosphate cement of claim 55 , wherein the pharmaceutical and/or a bioactive active ingredient comprises a therapeutic dose of a component selected from the group consisting of antibiotics, cytostatic agents, analgesics, disinfectants, growth factors, proteins and elastin inhibitors.
57. The magnesium ammonium phosphate cement of claim 45 , comprising providing a powder mixture having α-tricalcium phosphate.
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US12/727,643 US7942963B2 (en) | 2000-07-03 | 2010-03-19 | Magnesium ammonium phosphate cement composition |
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US10/070,670 US6692563B2 (en) | 2000-07-03 | 2001-07-03 | Magnesium-ammonium-phosphates cements, the production of the same and the use thereof |
US10/772,857 US6908506B2 (en) | 2000-07-03 | 2004-02-04 | Magnesium ammonium phosphate cement composition |
US11/104,392 US7115163B2 (en) | 2000-07-03 | 2005-04-11 | Magnesium ammonium phosphate cement composition |
US11/530,835 US7431763B2 (en) | 2000-07-03 | 2006-09-11 | Magnesium ammonium phosphate cement composition |
US11/841,651 US7540914B2 (en) | 2000-07-03 | 2007-08-20 | Magnesium ammonium phosphate cement composition |
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ES (2) | ES2397395T3 (en) |
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WO (1) | WO2002002478A1 (en) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102488921A (en) * | 2011-12-22 | 2012-06-13 | 韩大庆 | Auxiliary agent for enhancing biocompatibility of magnesium phosphate cement and magnesium phosphate cement |
US20130150978A1 (en) * | 2010-06-15 | 2013-06-13 | Innotere Gmbh | Bone implant comprising a magnesium-containing metallic material with reduced corrosion rate, and methods and kit for producing the bone implant |
Families Citing this family (134)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
RU2296526C2 (en) * | 1998-10-26 | 2007-04-10 | Икспэндинг Ортопедикс Инк. | Expandable orthopedic device |
DE10032220A1 (en) * | 2000-07-03 | 2002-01-24 | Sanatis Gmbh | Magnesium ammonium phosphate cements, their manufacture and use |
WO2003002243A2 (en) | 2001-06-27 | 2003-01-09 | Remon Medical Technologies Ltd. | Method and device for electrochemical formation of therapeutic species in vivo |
DE10225420A1 (en) * | 2002-06-07 | 2003-12-24 | Sanatis Gmbh | Strontium apatite cement preparations, the cements formed therefrom and the use thereof |
US7273523B2 (en) | 2002-06-07 | 2007-09-25 | Kyphon Inc. | Strontium-apatite-cement-preparations, cements formed therefrom, and uses thereof |
JP2006503615A (en) * | 2002-09-30 | 2006-02-02 | リージェン バイオテック インコーポレーテッド | Bone filling composition for promoting bone formation and osteosclerosis comprising calcium sulfate and a viscous polymer |
DE20218668U1 (en) * | 2002-12-03 | 2003-03-06 | Sanatis Gmbh | Recipes for cement preparations as a bone substitute |
AU2004212942A1 (en) | 2003-02-14 | 2004-09-02 | Depuy Spine, Inc. | In-situ formed intervertebral fusion device |
US7569626B2 (en) | 2003-06-05 | 2009-08-04 | Dfine, Inc. | Polymer composites for biomedical applications and methods of making |
US7032663B2 (en) * | 2003-06-27 | 2006-04-25 | Halliburton Energy Services, Inc. | Permeable cement and sand control methods utilizing permeable cement in subterranean well bores |
DE10339557A1 (en) * | 2003-08-26 | 2005-04-07 | Heraeus Kulzer Gmbh | Dental filling material |
WO2005027988A2 (en) * | 2003-09-05 | 2005-03-31 | Norian Corporation | Bone cement compositions having fiber-reinforcement and/or increased flowability |
US7828802B2 (en) | 2004-01-16 | 2010-11-09 | Expanding Orthopedics, Inc. | Bone fracture treatment devices and methods of their use |
US8029511B2 (en) * | 2004-03-22 | 2011-10-04 | Disc Dynamics, Inc. | Multi-stage biomaterial injection system for spinal implants |
US20060135959A1 (en) * | 2004-03-22 | 2006-06-22 | Disc Dynamics, Inc. | Nuclectomy method and apparatus |
ES2396133T3 (en) | 2004-04-27 | 2013-02-19 | Kyphon SÀRl | Bone replacement compositions and method of use |
FR2869544B1 (en) * | 2004-05-03 | 2006-07-21 | Centre Nat Rech Scient Cnrse | COMPOSITION FOR INJECTION CEMENT, USEFUL AS BONE SUBSTITUTE |
US7252841B2 (en) * | 2004-05-20 | 2007-08-07 | Skeletal Kinetics, Llc | Rapid setting calcium phosphate cements |
US20060095138A1 (en) * | 2004-06-09 | 2006-05-04 | Csaba Truckai | Composites and methods for treating bone |
US7678116B2 (en) | 2004-12-06 | 2010-03-16 | Dfine, Inc. | Bone treatment systems and methods |
US7559932B2 (en) | 2004-12-06 | 2009-07-14 | Dfine, Inc. | Bone treatment systems and methods |
US7722620B2 (en) | 2004-12-06 | 2010-05-25 | Dfine, Inc. | Bone treatment systems and methods |
US20060122614A1 (en) * | 2004-12-06 | 2006-06-08 | Csaba Truckai | Bone treatment systems and methods |
US20070102672A1 (en) * | 2004-12-06 | 2007-05-10 | Hamilton Judd D | Ceramic radiation shielding material and method of preparation |
US8070753B2 (en) | 2004-12-06 | 2011-12-06 | Dfine, Inc. | Bone treatment systems and methods |
US7717918B2 (en) | 2004-12-06 | 2010-05-18 | Dfine, Inc. | Bone treatment systems and methods |
US20090264939A9 (en) * | 2004-12-16 | 2009-10-22 | Martz Erik O | Instrument set and method for performing spinal nuclectomy |
PE20060861A1 (en) * | 2005-01-07 | 2006-10-25 | Celonova Biosciences Inc | IMPLANTABLE THREE-DIMENSIONAL BONE SUPPORT |
US7353876B2 (en) * | 2005-02-01 | 2008-04-08 | Halliburton Energy Services, Inc. | Self-degrading cement compositions and methods of using self-degrading cement compositions in subterranean formations |
US20060184192A1 (en) * | 2005-02-11 | 2006-08-17 | Markworth Aaron D | Systems and methods for providing cavities in interior body regions |
US20060253198A1 (en) * | 2005-05-03 | 2006-11-09 | Disc Dynamics, Inc. | Multi-lumen mold for intervertebral prosthesis and method of using same |
US20060265076A1 (en) * | 2005-05-03 | 2006-11-23 | Disc Dynamics, Inc. | Catheter holder for spinal implant |
US20060253199A1 (en) * | 2005-05-03 | 2006-11-09 | Disc Dynamics, Inc. | Lordosis creating nucleus replacement method and apparatus |
JP2008541958A (en) * | 2005-06-09 | 2008-11-27 | ドクトル ハー ツェー ロベルト マティス シュティフツング | Modeled product |
US20070010848A1 (en) * | 2005-07-11 | 2007-01-11 | Andrea Leung | Systems and methods for providing cavities in interior body regions |
ATE541528T1 (en) * | 2005-07-11 | 2012-02-15 | Kyphon Sarl | SYSTEM FOR INTRODUCING BIOCOMPATIBLE FILLING MATERIALS INTO INTERNAL BODY REGIONS |
US20070010824A1 (en) * | 2005-07-11 | 2007-01-11 | Hugues Malandain | Products, systems and methods for delivering material to bone and other internal body parts |
EP1909658A2 (en) * | 2005-07-11 | 2008-04-16 | Kyphon Inc. | Systems and methods for providing cavities in interior body regions |
US7670375B2 (en) | 2005-08-16 | 2010-03-02 | Benvenue Medical, Inc. | Methods for limiting the movement of material introduced between layers of spinal tissue |
US8366773B2 (en) | 2005-08-16 | 2013-02-05 | Benvenue Medical, Inc. | Apparatus and method for treating bone |
US9066769B2 (en) | 2005-08-22 | 2015-06-30 | Dfine, Inc. | Bone treatment systems and methods |
US8540723B2 (en) | 2009-04-14 | 2013-09-24 | Dfine, Inc. | Medical system and method of use |
US8777479B2 (en) | 2008-10-13 | 2014-07-15 | Dfine, Inc. | System for use in bone cement preparation and delivery |
US7651701B2 (en) * | 2005-08-29 | 2010-01-26 | Sanatis Gmbh | Bone cement composition and method of making the same |
US8840660B2 (en) | 2006-01-05 | 2014-09-23 | Boston Scientific Scimed, Inc. | Bioerodible endoprostheses and methods of making the same |
US8089029B2 (en) | 2006-02-01 | 2012-01-03 | Boston Scientific Scimed, Inc. | Bioabsorbable metal medical device and method of manufacture |
US20070191931A1 (en) * | 2006-02-16 | 2007-08-16 | Jan Weber | Bioerodible endoprostheses and methods of making the same |
US9526814B2 (en) * | 2006-02-16 | 2016-12-27 | Boston Scientific Scimed, Inc. | Medical balloons and methods of making the same |
KR100751566B1 (en) * | 2006-03-29 | 2007-08-22 | 리머스(주) | Preparing method of flame retardant composition comprising ammonium magnesium phosphate and flameproof process using the same |
US8048150B2 (en) | 2006-04-12 | 2011-11-01 | Boston Scientific Scimed, Inc. | Endoprosthesis having a fiber meshwork disposed thereon |
US7754005B2 (en) * | 2006-05-02 | 2010-07-13 | Kyphon Sarl | Bone cement compositions comprising an indicator agent and related methods thereof |
US7507286B2 (en) * | 2006-06-08 | 2009-03-24 | Sanatis Gmbh | Self-foaming cement for void filling and/or delivery systems |
US20080009876A1 (en) * | 2006-07-07 | 2008-01-10 | Meera Sankaran | Medical device with expansion mechanism |
US20080027456A1 (en) * | 2006-07-19 | 2008-01-31 | Csaba Truckai | Bone treatment systems and methods |
EP2054537A2 (en) | 2006-08-02 | 2009-05-06 | Boston Scientific Scimed, Inc. | Endoprosthesis with three-dimensional disintegration control |
WO2008034047A2 (en) | 2006-09-15 | 2008-03-20 | Boston Scientific Limited | Endoprosthesis with adjustable surface features |
EP2210625B8 (en) | 2006-09-15 | 2012-02-29 | Boston Scientific Scimed, Inc. | Bioerodible endoprosthesis with biostable inorganic layers |
EP2081616B1 (en) | 2006-09-15 | 2017-11-01 | Boston Scientific Scimed, Inc. | Bioerodible endoprostheses and methods of making the same |
CA2663220A1 (en) | 2006-09-15 | 2008-03-20 | Boston Scientific Limited | Medical devices and methods of making the same |
JP2010503494A (en) | 2006-09-15 | 2010-02-04 | ボストン サイエンティフィック リミテッド | Biodegradable endoprosthesis and method for producing the same |
US8002821B2 (en) | 2006-09-18 | 2011-08-23 | Boston Scientific Scimed, Inc. | Bioerodible metallic ENDOPROSTHESES |
US7963942B2 (en) * | 2006-09-20 | 2011-06-21 | Boston Scientific Scimed, Inc. | Medical balloons with modified surfaces |
WO2008039382A2 (en) * | 2006-09-21 | 2008-04-03 | Kyphon Sarl | Diammonium phosphate and other ammonium salts and their use in preventing clotting |
WO2008073190A2 (en) * | 2006-11-03 | 2008-06-19 | Kyphon Sarl | Materials and methods and systems for delivering localized medical treatments |
US8105382B2 (en) | 2006-12-07 | 2012-01-31 | Interventional Spine, Inc. | Intervertebral implant |
US8696679B2 (en) | 2006-12-08 | 2014-04-15 | Dfine, Inc. | Bone treatment systems and methods |
ES2506144T3 (en) | 2006-12-28 | 2014-10-13 | Boston Scientific Limited | Bioerodible endoprosthesis and their manufacturing procedure |
US20090287309A1 (en) | 2007-01-30 | 2009-11-19 | Tornier Sas | Intra-articular joint replacement |
FR2911773B1 (en) * | 2007-01-30 | 2009-03-27 | Tornier Sas | METHOD AND ASSEMBLY OF SURGICAL INSTRUMENTATION FOR POSITIONING A TOTAL REVERSE SHOULDER PROSTHESIS, AND CORRESPONDING PROSTHESIS |
EP2124778B1 (en) | 2007-02-21 | 2019-09-25 | Benvenue Medical, Inc. | Devices for treating the spine |
EP2124777A4 (en) | 2007-02-21 | 2013-06-05 | Benvenue Medical Inc | Devices for treating the spine |
JP5174887B2 (en) | 2007-04-03 | 2013-04-03 | ディーエフアイエヌイー・インコーポレーテッド | Bone processing system and method |
WO2008137428A2 (en) | 2007-04-30 | 2008-11-13 | Dfine, Inc. | Bone treatment systems and methods |
CN101269241B (en) * | 2007-04-30 | 2011-04-27 | 四川大学华西医院 | Calcium sulphate composite bone renovation material, preparation method and application thereof |
US9764057B2 (en) | 2007-06-06 | 2017-09-19 | Innotere Gmbh | Hydraulic cement-based implant material and use thereof |
US8900307B2 (en) | 2007-06-26 | 2014-12-02 | DePuy Synthes Products, LLC | Highly lordosed fusion cage |
US9597118B2 (en) | 2007-07-20 | 2017-03-21 | Dfine, Inc. | Bone anchor apparatus and method |
US8052745B2 (en) | 2007-09-13 | 2011-11-08 | Boston Scientific Scimed, Inc. | Endoprosthesis |
EP2237748B1 (en) | 2008-01-17 | 2012-09-05 | Synthes GmbH | An expandable intervertebral implant |
US9445854B2 (en) | 2008-02-01 | 2016-09-20 | Dfine, Inc. | Bone treatment systems and methods |
US8487021B2 (en) | 2008-02-01 | 2013-07-16 | Dfine, Inc. | Bone treatment systems and methods |
DE102008010210A1 (en) | 2008-02-20 | 2009-08-27 | Innotere Gmbh | Preparation for magnesium ammonium phosphate cements |
CA2720580A1 (en) | 2008-04-05 | 2009-10-08 | Synthes Usa, Llc | Expandable intervertebral implant |
US9180416B2 (en) | 2008-04-21 | 2015-11-10 | Dfine, Inc. | System for use in bone cement preparation and delivery |
US7968616B2 (en) * | 2008-04-22 | 2011-06-28 | Kyphon Sarl | Bone cement composition and method |
US7998192B2 (en) | 2008-05-09 | 2011-08-16 | Boston Scientific Scimed, Inc. | Endoprostheses |
US8236046B2 (en) | 2008-06-10 | 2012-08-07 | Boston Scientific Scimed, Inc. | Bioerodible endoprosthesis |
US7985252B2 (en) | 2008-07-30 | 2011-07-26 | Boston Scientific Scimed, Inc. | Bioerodible endoprosthesis |
US8382824B2 (en) | 2008-10-03 | 2013-02-26 | Boston Scientific Scimed, Inc. | Medical implant having NANO-crystal grains with barrier layers of metal nitrides or fluorides |
US20100160921A1 (en) * | 2008-12-19 | 2010-06-24 | Arthrocare Corporation | Cancellous bone displacement system and methods of use |
US8123752B2 (en) * | 2009-01-23 | 2012-02-28 | Spartek Medical. Inc. | Systems and methods for injecting bone filler into the spine |
WO2010094813A1 (en) * | 2009-02-10 | 2010-08-26 | Azurebio, S. L. | Osseous regeneration material from combinations of monetite with other bioactive calcium compounds |
EP2403546A2 (en) | 2009-03-02 | 2012-01-11 | Boston Scientific Scimed, Inc. | Self-buffering medical implants |
US8535327B2 (en) | 2009-03-17 | 2013-09-17 | Benvenue Medical, Inc. | Delivery apparatus for use with implantable medical devices |
US9526620B2 (en) | 2009-03-30 | 2016-12-27 | DePuy Synthes Products, Inc. | Zero profile spinal fusion cage |
US9393129B2 (en) | 2009-12-10 | 2016-07-19 | DePuy Synthes Products, Inc. | Bellows-like expandable interbody fusion cage |
WO2011075745A2 (en) * | 2009-12-18 | 2011-06-23 | Palmaz Scientific, Inc. | Interosteal and intramedullary implants and method of implanting same |
US9180137B2 (en) | 2010-02-09 | 2015-11-10 | Bone Support Ab | Preparation of bone cement compositions |
ES2365091B1 (en) | 2010-03-12 | 2013-01-24 | Universitat Politècnica De Catalunya | AN INORGANIC CEMENT FOR BIOMEDICAL APPLICATIONS, PROCEDURE FOR THE PREPARATION AND USE OF SUCH CEMENT. |
US8668732B2 (en) | 2010-03-23 | 2014-03-11 | Boston Scientific Scimed, Inc. | Surface treated bioerodible metal endoprostheses |
US9408652B2 (en) | 2010-04-27 | 2016-08-09 | Tornier Sas | Intra-articular joint replacement and method |
US8979860B2 (en) | 2010-06-24 | 2015-03-17 | DePuy Synthes Products. LLC | Enhanced cage insertion device |
US9907560B2 (en) | 2010-06-24 | 2018-03-06 | DePuy Synthes Products, Inc. | Flexible vertebral body shavers |
AU2011271465B2 (en) | 2010-06-29 | 2015-03-19 | Synthes Gmbh | Distractible intervertebral implant |
US8668770B2 (en) * | 2010-08-20 | 2014-03-11 | Mohammad Ali Saghiri | Dental cement composition |
CA2809606C (en) | 2010-08-26 | 2020-12-01 | University Of Louisville Research Foundation, Inc. | Compositions and methods for treating bone defects |
WO2012045013A2 (en) * | 2010-10-01 | 2012-04-05 | Skeletal Kinetics, Llc | Porogen containing calcium phosphate cement compositions |
US9402732B2 (en) | 2010-10-11 | 2016-08-02 | DePuy Synthes Products, Inc. | Expandable interspinous process spacer implant |
WO2012178018A2 (en) | 2011-06-24 | 2012-12-27 | Benvenue Medical, Inc. | Devices and methods for treating bone tissue |
WO2013029185A1 (en) * | 2011-08-31 | 2013-03-07 | Metallic Organic Ltd | Magnesium phosphate biomaterials |
JP5834355B2 (en) * | 2011-09-28 | 2015-12-16 | クラレノリタケデンタル株式会社 | Hypersensitivity inhibitor and method for producing the same |
CN104837512B (en) | 2012-01-31 | 2017-06-23 | 托莱多大学 | Injectable, biodegradable bone cement and production and preparation method thereof |
KR101376076B1 (en) * | 2012-08-09 | 2014-03-19 | 한국수력원자력 주식회사 | composition and it's manufacture method of sacrificial concrete for ex-vessel core cooling system |
KR101357673B1 (en) | 2012-09-03 | 2014-02-04 | 한국기계연구원 | The scaffold composition for regeneration of hard tissue having magnesium phosphate, scaffold for regeneration of hard tissue comprising the same and preparation methods thereof |
CA2901528C (en) | 2013-02-20 | 2022-07-26 | Bone Support Ab | Heat-treated, sintered and micronized hydroxyapatite powder for use in a hardenable bone substitute composition |
US9522070B2 (en) | 2013-03-07 | 2016-12-20 | Interventional Spine, Inc. | Intervertebral implant |
US10085783B2 (en) | 2013-03-14 | 2018-10-02 | Izi Medical Products, Llc | Devices and methods for treating bone tissue |
CN104107455B (en) * | 2013-04-19 | 2018-12-14 | 中国人民解放军第二军医大学 | A kind of bone cement and its slurry |
CA2926421C (en) | 2013-10-08 | 2022-05-03 | Vivorte, Inc. | Processed bone particle compositions and related methods |
FR3030498B1 (en) * | 2014-12-23 | 2019-06-07 | Saint-Gobain Weber | ACIDO-BASIC BINDER COMPRISING PHOSPHATE CEMENTS |
US11426290B2 (en) | 2015-03-06 | 2022-08-30 | DePuy Synthes Products, Inc. | Expandable intervertebral implant, system, kit and method |
EP3231453B1 (en) | 2016-04-14 | 2019-12-25 | Immundiagnostik AG | Bone sialoprotein(bsp)-functionalised bone replacement bodies |
US11596523B2 (en) | 2016-06-28 | 2023-03-07 | Eit Emerging Implant Technologies Gmbh | Expandable and angularly adjustable articulating intervertebral cages |
EP3474783B1 (en) | 2016-06-28 | 2023-05-03 | Eit Emerging Implant Technologies GmbH | Expandable, angularly adjustable intervertebral cages |
US10888433B2 (en) | 2016-12-14 | 2021-01-12 | DePuy Synthes Products, Inc. | Intervertebral implant inserter and related methods |
US10398563B2 (en) | 2017-05-08 | 2019-09-03 | Medos International Sarl | Expandable cage |
US11344424B2 (en) | 2017-06-14 | 2022-05-31 | Medos International Sarl | Expandable intervertebral implant and related methods |
US10940016B2 (en) | 2017-07-05 | 2021-03-09 | Medos International Sarl | Expandable intervertebral fusion cage |
CN108392673B (en) * | 2018-02-26 | 2021-07-06 | 南昌大学 | Borosilicate bioglass/magnesium phosphate composite bone cement and low-temperature 3D printing method of bone scaffold thereof |
US11446156B2 (en) | 2018-10-25 | 2022-09-20 | Medos International Sarl | Expandable intervertebral implant, inserter instrument, and related methods |
US11426286B2 (en) | 2020-03-06 | 2022-08-30 | Eit Emerging Implant Technologies Gmbh | Expandable intervertebral implant |
US11850160B2 (en) | 2021-03-26 | 2023-12-26 | Medos International Sarl | Expandable lordotic intervertebral fusion cage |
US11752009B2 (en) | 2021-04-06 | 2023-09-12 | Medos International Sarl | Expandable intervertebral fusion cage |
CN113443849B (en) * | 2021-07-28 | 2022-12-02 | 喜跃发国际环保新材料股份有限公司 | Retarder for magnesium phosphate cement and use method thereof |
Citations (87)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3746680A (en) * | 1971-03-03 | 1973-07-17 | Johnson & Johnson | Plaster of paris composition |
US4141864A (en) * | 1974-03-15 | 1979-02-27 | University Of Virginia Alumni Patents Foundation | Osseous cement composition |
US4192021A (en) * | 1976-05-12 | 1980-03-11 | Batelle-Institut e.V. | Bone replacement or prosthesis anchoring material |
US4239113A (en) * | 1977-06-02 | 1980-12-16 | Kulzer & Co. Gmbh | Composition for the preparation of bone cement |
US4341691A (en) * | 1980-02-20 | 1982-07-27 | Zimmer, Inc. | Low viscosity bone cement |
US4404327A (en) * | 1979-10-31 | 1983-09-13 | Crugnola Aldo M | Orthopaedic cement from acrylate polymers |
US4518430A (en) * | 1982-04-29 | 1985-05-21 | American Dental Association Health Foundation | Dental resptorative cement pastes |
US4588583A (en) * | 1982-12-11 | 1986-05-13 | Beiersdorf Aktiengesellschaft | Surgical material |
US4612053A (en) * | 1983-10-06 | 1986-09-16 | American Dental Association Health Foundation | Combinations of sparingly soluble calcium phosphates in slurries and pastes as mineralizers and cements |
US4629464A (en) * | 1984-09-25 | 1986-12-16 | Tdk Corporation | Porous hydroxyapatite material for artificial bone substitute |
US4678436A (en) * | 1985-05-27 | 1987-07-07 | G-C Dental Industrial Corp. | Color-changeable cement composition for dental use |
US4721659A (en) * | 1985-11-12 | 1988-01-26 | Stauffer Chemical Company | Process for applying a cementitious material to a structural base and article produced therefrom |
US4722948A (en) * | 1984-03-16 | 1988-02-02 | Dynatech Corporation | Bone replacement and repair putty material from unsaturated polyester resin and vinyl pyrrolidone |
US4791150A (en) * | 1985-10-01 | 1988-12-13 | Bonar Cole Polymers Limited | Composition for use in making bone cement |
US4872936A (en) * | 1985-10-09 | 1989-10-10 | Ernst Muhlbauer Kg | Polymerizable cement mixtures |
US4902649A (en) * | 1986-09-10 | 1990-02-20 | Showa Denko Kabushiki Kaisha | Hard tissue substitute composition |
US4940689A (en) * | 1987-06-06 | 1990-07-10 | Sony Corporation | Display material |
US4957352A (en) * | 1987-07-29 | 1990-09-18 | Sony Corporation | Electrochromic display device |
US4959104A (en) * | 1985-10-11 | 1990-09-25 | Mitsui Toatsu Chemicals, Inc. | Self-hardenable material |
US5004501A (en) * | 1988-06-01 | 1991-04-02 | Tecres Spa | Two phase cement mixture, particularly suitable for othopaedics |
US5108956A (en) * | 1988-03-11 | 1992-04-28 | Kanto Kagaku Kabushiki Kaisha | Process for the preparation of microspherical sintered bodies of hydroxyapatite and a chromatographic packing material comprising the microspherical sintered bodies of hydroxyapatite |
US5149368A (en) * | 1991-01-10 | 1992-09-22 | Liu Sung Tsuen | Resorbable bioactive calcium phosphate cement |
US5160371A (en) * | 1989-04-28 | 1992-11-03 | Sony Corporation | Display composition, coloring pigment, and recording material |
US5171720A (en) * | 1988-09-20 | 1992-12-15 | Asahi Kogaku Kogyo K.K. | Porous ceramic sinter and process for producing same |
US5179065A (en) * | 1989-04-28 | 1993-01-12 | Sony Corporation | Recording material with a display composition including a coloring pigment |
US5204382A (en) * | 1992-02-28 | 1993-04-20 | Collagen Corporation | Injectable ceramic compositions and methods for their preparation and use |
US5205928A (en) * | 1988-03-11 | 1993-04-27 | Kanto Kagaku Kabushiki Kaisha | Process for the preparation of microspherical sintered bodies of hydroxyapatite and a chromatographic packing material comprising the microspherical sintered bodies of hydroxyapatite |
US5226877A (en) * | 1989-06-23 | 1993-07-13 | Epstein Gordon H | Method and apparatus for preparing fibrinogen adhesive from whole blood |
US5262166A (en) * | 1991-04-17 | 1993-11-16 | Lty Medical Inc | Resorbable bioactive phosphate containing cements |
US5276070A (en) * | 1990-01-25 | 1994-01-04 | Pfizer Hospital Products Group, Inc. | Bone cement |
US5281265A (en) * | 1992-02-03 | 1994-01-25 | Liu Sung Tsuen | Resorbable surgical cements |
US5352715A (en) * | 1992-02-28 | 1994-10-04 | Collagen Corporation | Injectable ceramic compositions and methods for their preparation and use |
US5462722A (en) * | 1991-04-17 | 1995-10-31 | Liu; Sung-Tsuen | Calcium phosphate calcium sulfate composite implant material |
US5522893A (en) * | 1993-03-12 | 1996-06-04 | American Dental Association Health Foundation | Calcium phosphate hydroxyapatite precursor and methods for making and using the same |
US5605713A (en) * | 1991-11-22 | 1997-02-25 | Boltong; Maria G. | Process for the preparation of calcium phosphate cements and its application as bio-materials |
US5650108A (en) * | 1994-10-06 | 1997-07-22 | Merck Patent Gesellschaft Mit Beschrankter Haftung | Porous bone replacement materials |
US5795922A (en) * | 1995-06-06 | 1998-08-18 | Clemson University | Bone cement composistion containing microencapsulated radiopacifier and method of making same |
US5797873A (en) * | 1994-09-17 | 1998-08-25 | Merck Patent Gesellschaft Mit Beschrankter Haftung | Process for the preparation of bone cements comprising active compounds |
US5814683A (en) * | 1995-12-06 | 1998-09-29 | Hewlett-Packard Company | Polymeric additives for the elimination of ink jet aerosol generation |
US5847046A (en) * | 1997-03-12 | 1998-12-08 | United States Surgical Corporation | Biodegradable bone cement |
US5952010A (en) * | 1988-04-20 | 1999-09-14 | Norian Corporation | Paste compositions capable of setting into carbonated apatite |
US6075067A (en) * | 1994-08-15 | 2000-06-13 | Corpipharm Gmbh & Co | Cement for medical use, method for producing the cement, and use of the cement |
US6124373A (en) * | 1998-04-10 | 2000-09-26 | Wm. Marsh Rice University | Bone replacement compound comprising poly(polypropylene fumarate) |
US6153664A (en) * | 1997-04-18 | 2000-11-28 | Cambridge Scientific, Inc. | Bioerodible polymeric semi-interpenetrating network alloys and internal fixation devices made therefrom |
US6187046B1 (en) * | 1997-03-14 | 2001-02-13 | Asahi Kogaku Kogyo Kabushiki Kaisha | Prosthetic bone material and process for the production of the same |
US6203574B1 (en) * | 1998-04-14 | 2001-03-20 | Asahi Kogaku Kogyo Kabushiki Kaisha | Prosthetic bone filler and process for the production of the same |
US6206957B1 (en) * | 1998-04-16 | 2001-03-27 | Merck Patent Gesellschaft Mit Beschrankter Haftung | Tricalcium phosphate-containing biocement pastes comprising cohesion promoters |
US6224635B1 (en) * | 1998-11-06 | 2001-05-01 | Hospital For Joint Diseases | Implantation of surgical implants with calcium sulfate |
US6231615B1 (en) * | 1997-10-14 | 2001-05-15 | Parallax Medical, Inc. | Enhanced visibility materials for implantation in hard tissue |
US6241734B1 (en) * | 1998-08-14 | 2001-06-05 | Kyphon, Inc. | Systems and methods for placing materials into bone |
US6248110B1 (en) * | 1994-01-26 | 2001-06-19 | Kyphon, Inc. | Systems and methods for treating fractured or diseased bone using expandable bodies |
US6273916B1 (en) * | 1999-09-02 | 2001-08-14 | Cook Incorporated | Method and apparatus for strengthening vertebral bodies |
US6338810B1 (en) * | 1997-12-23 | 2002-01-15 | Commissariat A L'energie Atomique | Method for making apatite ceramics, in particular for biological use |
US6436143B1 (en) * | 1999-02-22 | 2002-08-20 | Anthony C. Ross | Method and apparatus for treating intervertebral disks |
US20020152929A1 (en) * | 2001-02-12 | 2002-10-24 | Ivoclar Vivadent Ag. | Thermochromic dental material |
US20020167480A1 (en) * | 2001-04-25 | 2002-11-14 | Johnson Mark Thomas | Electrophoretic color display device |
US20030032964A1 (en) * | 2001-02-15 | 2003-02-13 | Neil Watkins | Vertebroplasty bone cement |
US20030031698A1 (en) * | 2000-01-31 | 2003-02-13 | Roeder Ryan K. | Composite biomaterial including anisometric calcium phosphate reinforcement particles and related methods |
US6521264B1 (en) * | 1998-03-20 | 2003-02-18 | Teknimed | Method for preparing a biomaterial based on hydroxyapatite, resulting biomaterial and surgical or dental use |
US20030055512A1 (en) * | 2001-05-21 | 2003-03-20 | Genin Francois Y. | Calcium based neutral and bioresorbable bone graft |
US6547866B1 (en) * | 2000-10-30 | 2003-04-15 | Howmedica Osteonics Corp. | Porous calcium phosphate cement |
US6562755B1 (en) * | 2000-10-31 | 2003-05-13 | Ncr Corporation | Thermal paper with security features |
US6593394B1 (en) * | 2000-01-03 | 2003-07-15 | Prosperous Kingdom Limited | Bioactive and osteoporotic bone cement |
US20030139488A1 (en) * | 2002-01-18 | 2003-07-24 | Loctite Corporation | (Meth) Acrylate compositions having a self-indicator of cure and methods of detecting cure |
US20030161858A1 (en) * | 2000-04-11 | 2003-08-28 | Lars Lidgren | Injectable bone mineral substitute material |
US20030180344A1 (en) * | 2002-02-05 | 2003-09-25 | Cambridge Scientific, Inc. | Bioresorbable osteoconductive compositions for bone regeneration |
US6692563B2 (en) * | 2000-07-03 | 2004-02-17 | Kyphon, Inc. | Magnesium-ammonium-phosphates cements, the production of the same and the use thereof |
US20040048947A1 (en) * | 2000-07-17 | 2004-03-11 | Lars Lidgren | Composition for an injectable bone mineral substitute material |
US20040122359A1 (en) * | 2002-09-17 | 2004-06-24 | Kyphon Inc. | Apparatus and methods for mixing two components |
US20040157952A1 (en) * | 2001-05-30 | 2004-08-12 | Renzo Soffiati | Bone cement containing coated radiopaque particles and its preparation |
US20040226479A1 (en) * | 1995-02-08 | 2004-11-18 | M.E.D. Usa, Inc. | Bone cement compositions comprising fused fibrous compounds |
US20050105384A1 (en) * | 2003-11-18 | 2005-05-19 | Scimed Life Systems, Inc. | Apparatus for mixing and dispensing a multi-component bone cement |
US20050199156A1 (en) * | 2004-02-10 | 2005-09-15 | Ibrahim Khairoun | Macroporous, resorbable and injectible calcium phosphate-based cements (MCPC) for bone repair, augmentation, regeneration, and osteoporosis treatment |
US6953594B2 (en) * | 1996-10-10 | 2005-10-11 | Etex Corporation | Method of preparing a poorly crystalline calcium phosphate and methods of its use |
US20050256220A1 (en) * | 2004-05-14 | 2005-11-17 | Ceravic Sas | Polymer cement for percutaneous vertebroplasty |
US6994726B2 (en) * | 2004-05-25 | 2006-02-07 | Calcitec, Inc. | Dual function prosthetic bone implant and method for preparing the same |
US20060079905A1 (en) * | 2003-06-17 | 2006-04-13 | Disc-O-Tech Medical Technologies Ltd. | Methods, materials and apparatus for treating bone and other tissue |
US7135027B2 (en) * | 2002-10-04 | 2006-11-14 | Baxter International, Inc. | Devices and methods for mixing and extruding medically useful compositions |
US7138442B2 (en) * | 2002-08-30 | 2006-11-21 | Biomet, Inc. | Reduced exothermic bone replacement cement |
US7160932B2 (en) * | 2002-12-20 | 2007-01-09 | Biomet Deutschland Gmbh | Bone cement having improved mechanical properties, and process for the preparation thereof |
US20070021526A1 (en) * | 2005-07-22 | 2007-01-25 | Howmedica Osteonics Corp. | Setting time indicator for acrylic bone cement |
US20070032567A1 (en) * | 2003-06-17 | 2007-02-08 | Disc-O-Tech Medical | Bone Cement And Methods Of Use Thereof |
US20070048382A1 (en) * | 2005-08-29 | 2007-03-01 | Jorg Meyer | Bone cement composition and method of making the same |
US20070128245A1 (en) * | 2005-12-06 | 2007-06-07 | Rosenberg Aron D | Porous calcium phosphate bone material |
US20070191964A1 (en) * | 2001-04-04 | 2007-08-16 | Arthrocare Corporation | Enhanced visibility materials for implantation in hard tissue |
US7273523B2 (en) * | 2002-06-07 | 2007-09-25 | Kyphon Inc. | Strontium-apatite-cement-preparations, cements formed therefrom, and uses thereof |
US20070254011A1 (en) * | 2003-11-22 | 2007-11-01 | Matthias Schnabelrauch | Bone Formation Agent and Method of Production |
Family Cites Families (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6002065A (en) | 1988-04-20 | 1999-12-14 | Norian Corporation | Kits for preparing calcium phosphate minerals |
JPH03165773A (en) * | 1989-11-27 | 1991-07-17 | Tdk Corp | Composition for living body and material for living body |
JP2963133B2 (en) * | 1990-03-16 | 1999-10-12 | 日本化学工業株式会社 | Antibacterial apatite |
JP2808340B2 (en) * | 1990-03-20 | 1998-10-08 | 日本電気硝子株式会社 | Bone repair material |
WO1992002478A1 (en) | 1990-07-27 | 1992-02-20 | Exxon Chemical Patents Inc. | Hydrocarbon treatment |
EP0473048B1 (en) | 1990-08-21 | 1996-11-27 | Asahi Glass Company Ltd. | Calcium phosphate type glass-ceramic |
DE69214005T2 (en) | 1991-05-01 | 1997-05-15 | Chichibu Onoda Cement Corp | Hardening compositions for use in medicine or dentistry |
EP0520690B1 (en) | 1991-06-26 | 1995-11-02 | Nitta Gelatin Inc. | Calcium phosphate type hardening material for repairing living hard tissue |
ES2040626B1 (en) | 1991-11-22 | 1994-05-16 | Boltong Maria G | PROCEDURE FOR THE OBTAINING OF CALCIUM PHOSPHATE CEMENTS AND THEIR USE AS BIOMTERIALS. |
US5569442A (en) | 1994-11-04 | 1996-10-29 | Norian Corporation | Reactive tricalcium phosphate compositions and uses |
AUPN291195A0 (en) * | 1995-05-10 | 1995-06-01 | James Hardie Research Pty Limited | A hydrated composition |
DE29607832U1 (en) | 1996-04-30 | 1996-10-24 | Huebner Eike Gerhard | Indicator for the hardening of bone cement |
JPH10167853A (en) * | 1996-12-11 | 1998-06-23 | Shigeharu Takagi | Porous ceramic compact for artificial bone material |
DE19853832A1 (en) | 1998-11-21 | 2000-05-25 | Merck Patent Gmbh | Calcium phosphate cements containing polyalkenoic acids |
JP2004511320A (en) | 2000-10-16 | 2004-04-15 | ユニバーシテイ・オブ・サウス・カロライナ | Biocompatible cement containing reactive calcium phosphate nanoparticles and methods of making and using said cement |
US20020191487A1 (en) | 2000-10-25 | 2002-12-19 | Kyphon Inc. | Systems and methods for mixing and transferring flowable materials |
US20040265385A1 (en) | 2001-04-12 | 2004-12-30 | Therics, Inc. | Porous biostructure partially occupied by interpenetrant and method for making same |
TWI267378B (en) | 2001-06-08 | 2006-12-01 | Wyeth Corp | Calcium phosphate delivery vehicles for osteoinductive proteins |
FR2838334B1 (en) | 2002-04-16 | 2006-05-26 | Polymerexpert Sa | NON-TOXIC RADICAL POLYMERIZATION ACTIVATOR FOR BONE OR DENTAL CEMENT |
DE10225420A1 (en) | 2002-06-07 | 2003-12-24 | Sanatis Gmbh | Strontium apatite cement preparations, the cements formed therefrom and the use thereof |
DE20218668U1 (en) | 2002-12-03 | 2003-03-06 | Sanatis Gmbh | Recipes for cement preparations as a bone substitute |
DE112004001799D2 (en) | 2003-07-18 | 2006-07-06 | Biomet Deutschland Gmbh | Surfactant-containing bone cement |
US7507286B2 (en) | 2006-06-08 | 2009-03-24 | Sanatis Gmbh | Self-foaming cement for void filling and/or delivery systems |
-
2000
- 2000-07-03 DE DE10032220A patent/DE10032220A1/en not_active Ceased
-
2001
- 2001-07-03 US US10/070,670 patent/US6692563B2/en not_active Expired - Lifetime
- 2001-07-03 DE DE50110049T patent/DE50110049D1/en not_active Expired - Lifetime
- 2001-07-03 WO PCT/EP2001/007605 patent/WO2002002478A1/en active IP Right Grant
- 2001-07-03 CN CNB018018157A patent/CN100396641C/en not_active Expired - Fee Related
- 2001-07-03 AT AT01957914T patent/ATE328851T1/en active
- 2001-07-03 EP EP06011541A patent/EP1707543B1/en not_active Expired - Lifetime
- 2001-07-03 CA CA2383580A patent/CA2383580C/en not_active Expired - Fee Related
- 2001-07-03 EP EP01957914A patent/EP1296909B1/en not_active Expired - Lifetime
- 2001-07-03 ES ES06011541T patent/ES2397395T3/en not_active Expired - Lifetime
- 2001-07-03 JP JP2002507738A patent/JP5153046B2/en not_active Expired - Fee Related
- 2001-07-03 ES ES01957914T patent/ES2266226T3/en not_active Expired - Lifetime
- 2001-07-03 AU AU2001279710A patent/AU2001279710A1/en not_active Abandoned
-
2003
- 2003-06-03 HK HK03103919.9A patent/HK1051676A1/en not_active IP Right Cessation
-
2004
- 2004-02-04 US US10/772,857 patent/US6908506B2/en not_active Expired - Lifetime
-
2005
- 2005-04-11 US US11/104,392 patent/US7115163B2/en not_active Expired - Lifetime
-
2006
- 2006-09-11 US US11/530,835 patent/US7431763B2/en not_active Expired - Lifetime
-
2007
- 2007-08-20 US US11/841,651 patent/US7540914B2/en not_active Expired - Lifetime
-
2009
- 2009-05-11 US US12/463,880 patent/US20090221717A1/en not_active Abandoned
-
2010
- 2010-03-19 US US12/727,643 patent/US7942963B2/en not_active Expired - Fee Related
Patent Citations (99)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3746680A (en) * | 1971-03-03 | 1973-07-17 | Johnson & Johnson | Plaster of paris composition |
US4141864A (en) * | 1974-03-15 | 1979-02-27 | University Of Virginia Alumni Patents Foundation | Osseous cement composition |
US4192021A (en) * | 1976-05-12 | 1980-03-11 | Batelle-Institut e.V. | Bone replacement or prosthesis anchoring material |
US4239113A (en) * | 1977-06-02 | 1980-12-16 | Kulzer & Co. Gmbh | Composition for the preparation of bone cement |
US4404327A (en) * | 1979-10-31 | 1983-09-13 | Crugnola Aldo M | Orthopaedic cement from acrylate polymers |
US4341691A (en) * | 1980-02-20 | 1982-07-27 | Zimmer, Inc. | Low viscosity bone cement |
US4518430A (en) * | 1982-04-29 | 1985-05-21 | American Dental Association Health Foundation | Dental resptorative cement pastes |
US4588583A (en) * | 1982-12-11 | 1986-05-13 | Beiersdorf Aktiengesellschaft | Surgical material |
US4612053A (en) * | 1983-10-06 | 1986-09-16 | American Dental Association Health Foundation | Combinations of sparingly soluble calcium phosphates in slurries and pastes as mineralizers and cements |
US4722948A (en) * | 1984-03-16 | 1988-02-02 | Dynatech Corporation | Bone replacement and repair putty material from unsaturated polyester resin and vinyl pyrrolidone |
US4629464A (en) * | 1984-09-25 | 1986-12-16 | Tdk Corporation | Porous hydroxyapatite material for artificial bone substitute |
US4678436A (en) * | 1985-05-27 | 1987-07-07 | G-C Dental Industrial Corp. | Color-changeable cement composition for dental use |
US4791150A (en) * | 1985-10-01 | 1988-12-13 | Bonar Cole Polymers Limited | Composition for use in making bone cement |
US4872936A (en) * | 1985-10-09 | 1989-10-10 | Ernst Muhlbauer Kg | Polymerizable cement mixtures |
US4959104A (en) * | 1985-10-11 | 1990-09-25 | Mitsui Toatsu Chemicals, Inc. | Self-hardenable material |
US4721659A (en) * | 1985-11-12 | 1988-01-26 | Stauffer Chemical Company | Process for applying a cementitious material to a structural base and article produced therefrom |
US4902649A (en) * | 1986-09-10 | 1990-02-20 | Showa Denko Kabushiki Kaisha | Hard tissue substitute composition |
US4940689A (en) * | 1987-06-06 | 1990-07-10 | Sony Corporation | Display material |
US4957352A (en) * | 1987-07-29 | 1990-09-18 | Sony Corporation | Electrochromic display device |
US5108956A (en) * | 1988-03-11 | 1992-04-28 | Kanto Kagaku Kabushiki Kaisha | Process for the preparation of microspherical sintered bodies of hydroxyapatite and a chromatographic packing material comprising the microspherical sintered bodies of hydroxyapatite |
US5205928A (en) * | 1988-03-11 | 1993-04-27 | Kanto Kagaku Kabushiki Kaisha | Process for the preparation of microspherical sintered bodies of hydroxyapatite and a chromatographic packing material comprising the microspherical sintered bodies of hydroxyapatite |
US5952010A (en) * | 1988-04-20 | 1999-09-14 | Norian Corporation | Paste compositions capable of setting into carbonated apatite |
US5004501A (en) * | 1988-06-01 | 1991-04-02 | Tecres Spa | Two phase cement mixture, particularly suitable for othopaedics |
US5171720A (en) * | 1988-09-20 | 1992-12-15 | Asahi Kogaku Kogyo K.K. | Porous ceramic sinter and process for producing same |
US5160371A (en) * | 1989-04-28 | 1992-11-03 | Sony Corporation | Display composition, coloring pigment, and recording material |
US5179065A (en) * | 1989-04-28 | 1993-01-12 | Sony Corporation | Recording material with a display composition including a coloring pigment |
US5226877A (en) * | 1989-06-23 | 1993-07-13 | Epstein Gordon H | Method and apparatus for preparing fibrinogen adhesive from whole blood |
US5276070A (en) * | 1990-01-25 | 1994-01-04 | Pfizer Hospital Products Group, Inc. | Bone cement |
US5149368A (en) * | 1991-01-10 | 1992-09-22 | Liu Sung Tsuen | Resorbable bioactive calcium phosphate cement |
US5262166A (en) * | 1991-04-17 | 1993-11-16 | Lty Medical Inc | Resorbable bioactive phosphate containing cements |
US5462722A (en) * | 1991-04-17 | 1995-10-31 | Liu; Sung-Tsuen | Calcium phosphate calcium sulfate composite implant material |
US5605713A (en) * | 1991-11-22 | 1997-02-25 | Boltong; Maria G. | Process for the preparation of calcium phosphate cements and its application as bio-materials |
US5281265A (en) * | 1992-02-03 | 1994-01-25 | Liu Sung Tsuen | Resorbable surgical cements |
US5204382A (en) * | 1992-02-28 | 1993-04-20 | Collagen Corporation | Injectable ceramic compositions and methods for their preparation and use |
US5352715A (en) * | 1992-02-28 | 1994-10-04 | Collagen Corporation | Injectable ceramic compositions and methods for their preparation and use |
US5545254A (en) * | 1993-03-12 | 1996-08-13 | The American Dental Association Health Foundation | Calcium phosphate hydroxyapatite precursor and methods for making and using the same |
US5522893A (en) * | 1993-03-12 | 1996-06-04 | American Dental Association Health Foundation | Calcium phosphate hydroxyapatite precursor and methods for making and using the same |
US5695729A (en) * | 1993-03-12 | 1997-12-09 | American Dental Association Health Foundation | Calcium phosphate hydroxyapatite precursor and methods for making and using the same |
US6248110B1 (en) * | 1994-01-26 | 2001-06-19 | Kyphon, Inc. | Systems and methods for treating fractured or diseased bone using expandable bodies |
US6075067A (en) * | 1994-08-15 | 2000-06-13 | Corpipharm Gmbh & Co | Cement for medical use, method for producing the cement, and use of the cement |
US5797873A (en) * | 1994-09-17 | 1998-08-25 | Merck Patent Gesellschaft Mit Beschrankter Haftung | Process for the preparation of bone cements comprising active compounds |
US5650108A (en) * | 1994-10-06 | 1997-07-22 | Merck Patent Gesellschaft Mit Beschrankter Haftung | Porous bone replacement materials |
US20040226479A1 (en) * | 1995-02-08 | 2004-11-18 | M.E.D. Usa, Inc. | Bone cement compositions comprising fused fibrous compounds |
US5795922A (en) * | 1995-06-06 | 1998-08-18 | Clemson University | Bone cement composistion containing microencapsulated radiopacifier and method of making same |
US5814683A (en) * | 1995-12-06 | 1998-09-29 | Hewlett-Packard Company | Polymeric additives for the elimination of ink jet aerosol generation |
US6953594B2 (en) * | 1996-10-10 | 2005-10-11 | Etex Corporation | Method of preparing a poorly crystalline calcium phosphate and methods of its use |
US5847046A (en) * | 1997-03-12 | 1998-12-08 | United States Surgical Corporation | Biodegradable bone cement |
US6187046B1 (en) * | 1997-03-14 | 2001-02-13 | Asahi Kogaku Kogyo Kabushiki Kaisha | Prosthetic bone material and process for the production of the same |
US6153664A (en) * | 1997-04-18 | 2000-11-28 | Cambridge Scientific, Inc. | Bioerodible polymeric semi-interpenetrating network alloys and internal fixation devices made therefrom |
US6231615B1 (en) * | 1997-10-14 | 2001-05-15 | Parallax Medical, Inc. | Enhanced visibility materials for implantation in hard tissue |
US20010012968A1 (en) * | 1997-10-14 | 2001-08-09 | Howard Preissman | Enhanced visibility materials for implantation in hard tissue |
US6309420B1 (en) * | 1997-10-14 | 2001-10-30 | Parallax Medical, Inc. | Enhanced visibility materials for implantation in hard tissue |
US6338810B1 (en) * | 1997-12-23 | 2002-01-15 | Commissariat A L'energie Atomique | Method for making apatite ceramics, in particular for biological use |
US6521264B1 (en) * | 1998-03-20 | 2003-02-18 | Teknimed | Method for preparing a biomaterial based on hydroxyapatite, resulting biomaterial and surgical or dental use |
US6124373A (en) * | 1998-04-10 | 2000-09-26 | Wm. Marsh Rice University | Bone replacement compound comprising poly(polypropylene fumarate) |
US6203574B1 (en) * | 1998-04-14 | 2001-03-20 | Asahi Kogaku Kogyo Kabushiki Kaisha | Prosthetic bone filler and process for the production of the same |
US6206957B1 (en) * | 1998-04-16 | 2001-03-27 | Merck Patent Gesellschaft Mit Beschrankter Haftung | Tricalcium phosphate-containing biocement pastes comprising cohesion promoters |
US6241734B1 (en) * | 1998-08-14 | 2001-06-05 | Kyphon, Inc. | Systems and methods for placing materials into bone |
US6613054B2 (en) * | 1998-08-14 | 2003-09-02 | Kyphon Inc. | Systems and methods for placing materials into bone |
US6224635B1 (en) * | 1998-11-06 | 2001-05-01 | Hospital For Joint Diseases | Implantation of surgical implants with calcium sulfate |
US6436143B1 (en) * | 1999-02-22 | 2002-08-20 | Anthony C. Ross | Method and apparatus for treating intervertebral disks |
US6273916B1 (en) * | 1999-09-02 | 2001-08-14 | Cook Incorporated | Method and apparatus for strengthening vertebral bodies |
US6593394B1 (en) * | 2000-01-03 | 2003-07-15 | Prosperous Kingdom Limited | Bioactive and osteoporotic bone cement |
US20030031698A1 (en) * | 2000-01-31 | 2003-02-13 | Roeder Ryan K. | Composite biomaterial including anisometric calcium phosphate reinforcement particles and related methods |
US20030161858A1 (en) * | 2000-04-11 | 2003-08-28 | Lars Lidgren | Injectable bone mineral substitute material |
US6908506B2 (en) * | 2000-07-03 | 2005-06-21 | Kyphon Inc. | Magnesium ammonium phosphate cement composition |
US20050246036A1 (en) * | 2000-07-03 | 2005-11-03 | Kyphon Inc. | Magnesium ammonium phosphate cement composition |
US7115163B2 (en) * | 2000-07-03 | 2006-10-03 | Kyphon Inc. | Magnesium ammonium phosphate cement composition |
US20070022912A1 (en) * | 2000-07-03 | 2007-02-01 | Kyphon Inc. | Magnesium Ammonium Phosphate Cement Composition |
US7540914B2 (en) * | 2000-07-03 | 2009-06-02 | Kyphon Sarl | Magnesium ammonium phosphate cement composition |
US20040173122A1 (en) * | 2000-07-03 | 2004-09-09 | Kyphon Inc. | Magnesium ammonium phosphate cement composition |
US6692563B2 (en) * | 2000-07-03 | 2004-02-17 | Kyphon, Inc. | Magnesium-ammonium-phosphates cements, the production of the same and the use thereof |
US20040048947A1 (en) * | 2000-07-17 | 2004-03-11 | Lars Lidgren | Composition for an injectable bone mineral substitute material |
US6547866B1 (en) * | 2000-10-30 | 2003-04-15 | Howmedica Osteonics Corp. | Porous calcium phosphate cement |
US6562755B1 (en) * | 2000-10-31 | 2003-05-13 | Ncr Corporation | Thermal paper with security features |
US20020152929A1 (en) * | 2001-02-12 | 2002-10-24 | Ivoclar Vivadent Ag. | Thermochromic dental material |
US7008433B2 (en) * | 2001-02-15 | 2006-03-07 | Depuy Acromed, Inc. | Vertebroplasty injection device |
US20030032964A1 (en) * | 2001-02-15 | 2003-02-13 | Neil Watkins | Vertebroplasty bone cement |
US20070191964A1 (en) * | 2001-04-04 | 2007-08-16 | Arthrocare Corporation | Enhanced visibility materials for implantation in hard tissue |
US20020167480A1 (en) * | 2001-04-25 | 2002-11-14 | Johnson Mark Thomas | Electrophoretic color display device |
US20030055512A1 (en) * | 2001-05-21 | 2003-03-20 | Genin Francois Y. | Calcium based neutral and bioresorbable bone graft |
US20040157952A1 (en) * | 2001-05-30 | 2004-08-12 | Renzo Soffiati | Bone cement containing coated radiopaque particles and its preparation |
US20030139488A1 (en) * | 2002-01-18 | 2003-07-24 | Loctite Corporation | (Meth) Acrylate compositions having a self-indicator of cure and methods of detecting cure |
US20030180344A1 (en) * | 2002-02-05 | 2003-09-25 | Cambridge Scientific, Inc. | Bioresorbable osteoconductive compositions for bone regeneration |
US7273523B2 (en) * | 2002-06-07 | 2007-09-25 | Kyphon Inc. | Strontium-apatite-cement-preparations, cements formed therefrom, and uses thereof |
US7138442B2 (en) * | 2002-08-30 | 2006-11-21 | Biomet, Inc. | Reduced exothermic bone replacement cement |
US20040122359A1 (en) * | 2002-09-17 | 2004-06-24 | Kyphon Inc. | Apparatus and methods for mixing two components |
US7135027B2 (en) * | 2002-10-04 | 2006-11-14 | Baxter International, Inc. | Devices and methods for mixing and extruding medically useful compositions |
US7160932B2 (en) * | 2002-12-20 | 2007-01-09 | Biomet Deutschland Gmbh | Bone cement having improved mechanical properties, and process for the preparation thereof |
US20060079905A1 (en) * | 2003-06-17 | 2006-04-13 | Disc-O-Tech Medical Technologies Ltd. | Methods, materials and apparatus for treating bone and other tissue |
US20070032567A1 (en) * | 2003-06-17 | 2007-02-08 | Disc-O-Tech Medical | Bone Cement And Methods Of Use Thereof |
US20050105384A1 (en) * | 2003-11-18 | 2005-05-19 | Scimed Life Systems, Inc. | Apparatus for mixing and dispensing a multi-component bone cement |
US20070254011A1 (en) * | 2003-11-22 | 2007-11-01 | Matthias Schnabelrauch | Bone Formation Agent and Method of Production |
US20050199156A1 (en) * | 2004-02-10 | 2005-09-15 | Ibrahim Khairoun | Macroporous, resorbable and injectible calcium phosphate-based cements (MCPC) for bone repair, augmentation, regeneration, and osteoporosis treatment |
US20050256220A1 (en) * | 2004-05-14 | 2005-11-17 | Ceravic Sas | Polymer cement for percutaneous vertebroplasty |
US6994726B2 (en) * | 2004-05-25 | 2006-02-07 | Calcitec, Inc. | Dual function prosthetic bone implant and method for preparing the same |
US20070021526A1 (en) * | 2005-07-22 | 2007-01-25 | Howmedica Osteonics Corp. | Setting time indicator for acrylic bone cement |
US20070048382A1 (en) * | 2005-08-29 | 2007-03-01 | Jorg Meyer | Bone cement composition and method of making the same |
US20070128245A1 (en) * | 2005-12-06 | 2007-06-07 | Rosenberg Aron D | Porous calcium phosphate bone material |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20130150978A1 (en) * | 2010-06-15 | 2013-06-13 | Innotere Gmbh | Bone implant comprising a magnesium-containing metallic material with reduced corrosion rate, and methods and kit for producing the bone implant |
US8974541B2 (en) * | 2010-06-15 | 2015-03-10 | Innotere Gmbh | Bone implant comprising a magnesium-containing metallic material with reduced corrosion rate, and methods and kit for producing the bone implant |
CN102488921A (en) * | 2011-12-22 | 2012-06-13 | 韩大庆 | Auxiliary agent for enhancing biocompatibility of magnesium phosphate cement and magnesium phosphate cement |
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US6908506B2 (en) | 2005-06-21 |
CN1383420A (en) | 2002-12-04 |
US20050246036A1 (en) | 2005-11-03 |
EP1296909B1 (en) | 2006-06-07 |
AU2001279710A1 (en) | 2002-01-14 |
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WO2002002478A1 (en) | 2002-01-10 |
EP1707543A1 (en) | 2006-10-04 |
US20070022912A1 (en) | 2007-02-01 |
JP5153046B2 (en) | 2013-02-27 |
US6692563B2 (en) | 2004-02-17 |
JP2004502626A (en) | 2004-01-29 |
ATE328851T1 (en) | 2006-06-15 |
US7431763B2 (en) | 2008-10-07 |
CN100396641C (en) | 2008-06-25 |
US20040173122A1 (en) | 2004-09-09 |
ES2266226T3 (en) | 2007-03-01 |
US20100173846A1 (en) | 2010-07-08 |
ES2397395T3 (en) | 2013-03-06 |
US20080020980A1 (en) | 2008-01-24 |
US7115163B2 (en) | 2006-10-03 |
CA2383580C (en) | 2011-03-22 |
US7540914B2 (en) | 2009-06-02 |
US20020166480A1 (en) | 2002-11-14 |
HK1051676A1 (en) | 2003-08-15 |
US7942963B2 (en) | 2011-05-17 |
EP1707543B1 (en) | 2012-11-14 |
EP1296909A1 (en) | 2003-04-02 |
CA2383580A1 (en) | 2002-01-10 |
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