US20070032856A1 - Drug eluting stent - Google Patents
Drug eluting stent Download PDFInfo
- Publication number
- US20070032856A1 US20070032856A1 US11/546,203 US54620306A US2007032856A1 US 20070032856 A1 US20070032856 A1 US 20070032856A1 US 54620306 A US54620306 A US 54620306A US 2007032856 A1 US2007032856 A1 US 2007032856A1
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- US
- United States
- Prior art keywords
- strut
- segment
- coating
- stent
- drug
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
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- A61F2/90—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure
- A61F2/91—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes
- A61F2/915—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes with bands having a meander structure, adjacent bands being connected to each other
- A61F2002/91516—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes with bands having a meander structure, adjacent bands being connected to each other the meander having a change in frequency along the band
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/82—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/86—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure
- A61F2/90—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure
- A61F2/91—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes
- A61F2/915—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes with bands having a meander structure, adjacent bands being connected to each other
- A61F2002/91533—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes with bands having a meander structure, adjacent bands being connected to each other characterised by the phase between adjacent bands
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2230/00—Geometry of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2230/0002—Two-dimensional shapes, e.g. cross-sections
- A61F2230/0004—Rounded shapes, e.g. with rounded corners
- A61F2230/0013—Horseshoe-shaped, e.g. crescent-shaped, C-shaped, U-shaped
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2250/00—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2250/0058—Additional features; Implant or prostheses properties not otherwise provided for
- A61F2250/0067—Means for introducing or releasing pharmaceutical products into the body
- A61F2250/0068—Means for introducing or releasing pharmaceutical products into the body the pharmaceutical product being in a reservoir
Definitions
- This invention relates to implantable medical devices, such as stents. More particularly, this invention relates to a stent having drug delivery capabilities.
- Percutaneous transluminal coronary angioplasty is a procedure for treating heart disease.
- a catheter assembly having a balloon portion is introduced into the cardiovascular system of a patient via the brachial or femoral artery.
- the catheter assembly is advanced through the coronary vasculature until the balloon portion is positioned across the occlusive lesion.
- the balloon is inflated to a predetermined size to radially compress against the atherosclerotic plaque of the lesion to remodel the lumen wall.
- the balloon is then deflated to a smaller profile to allow the catheter to be withdrawn from the patient's vasculature.
- a problem associated with the procedure includes formation of intimal flaps or torn arterial linings that can collapse and occlude the conduit after the balloon is deflated. Moreover, thrombosis and restenosis of the artery can develop over several months after the procedure, which can require another angioplasty procedure or a surgical bypass operation.
- an intraluminal prosthesis is implanted in the lumen to maintain the vascular patency.
- Stents are scaffolding structures, usually cylindrical or tubular in shape, functioning to physically hold open, and if desired, to expand the wall of the passageway. Typically stents are capable of being compressed for insertion through small cavities via small catheters, and then expanded to a larger diameter once at the desired location.
- One commonly applied technique for the local delivery of the drugs is through the use of medicated stents.
- One method of medicating stents involves the use of a polymeric carrier coated onto the body of the stent. A polymer dissolved in a solvent and a drug added thereto can be applied to the stent. Once the solvent evaporates, a coating of the polymer containing the drug remains on the stent.
- the embodiments of the present invention provide various stent structures for containing a coating, such as a polymeric coating, for the local delivery of a drug.
- a stent comprising a strut having a first segment, a second segment and a third segment located between the first and second segments, wherein the transverse cross sectional area of the third segment is less than the transverse cross sectional area of the first segment and the second segment; and a coating disposed on the third segment of the strut, wherein the first and second segments of the strut are free of any coating.
- the coating is disposed all the way around the third segment of the strut. The outer surface of the coating should not extend beyond the outer surface of the first or second segment of the strut.
- the coating can be made from a polymeric material containing a therapeutic substance.
- the strut includes a linear segment extending into a curved segment, wherein the first, second and third segments define a part of the linear segment of the strut.
- the curved segment can include a notch or can be smaller in thickness or width than the first or second segment of the strut.
- a radially expandable stent comprising a strut, at least a segment of the strut having a circumference smaller than the circumference of a remaining portion of the strut; and a coating supported by the segment of the strut having the smaller circumference.
- the strut can include four sides, wherein the width of the segment of the strut having the smaller circumference is less than the width of the remaining portion of the strut.
- the thickness of the segment of the strut having the smaller circumference is less than the thickness of the remaining portion of the strut.
- the coating can, for example, surround the segment of the strut having the reduced circumference. The remaining portion of the strut having the larger circumference can be free from any coating.
- a method of manufacturing a drug eluting stent comprising depositing a coating on a first segment of a strut of the stent, the stent including a second segment and a third segment, wherein the first segment is positioned between the second segment and the third segment, the first segment having a smaller transverse cross sectional area than the transverse cross sectional area of the second or third segment.
- a method of manufacturing a drug eluting stent comprising depositing a coating on a stent, the stent including a strut having a first segment, a second segment, and a third segment located between the first and second segments, wherein the transverse cross sectional area of the third segment is less than the transverse cross sectional area of the first segment and the second segment; and removing the coating off of the first and second segments so that the coating remains on the third segment.
- FIG. 1 illustrates an embodiment of a conventional stent
- FIG. 2 is an enlarged perspective view of the stent strut of encircled region 2 of FIG. 1 ;
- FIGS. 2A and 2B are transverse cross sectional views along the line 2 A- 2 A and 2 B- 2 B, respectively, of FIG. 2 ;
- FIGS. 3, 4 , 5 , 6 A, and 6 B are perspective views of a stent strut according to other embodiments of the invention.
- FIG. 1 illustrates one embodiment of a stent 10 that can be used with the practice of the present invention.
- Stent 10 can be generally cylindrical and radially self- or balloon-expandable. Stent 10 can be inserted and deployed in a patient with an appropriate delivery device such as a balloon dilatation catheter.
- Stent 10 can be made, for example, from a plurality of wave-like or serpentine-like struts 12 having curved segments and generally linear segments. Struts 12 are connected to the adjacent struts 12 via connecting elements 14 .
- the embodiments of the present invention should not be limited to the structure of FIG. 1 .
- a variety of other scaffolding designs can also be used, such as “V” shaped struts or Struts having a “zigzag” formation.
- the linear section of strut 12 includes a segment, referred to by reference number 16 , wherein any transverse cross sectional portion of segment 16 has a smaller cross sectional surface area than the remaining segment of strut 12 .
- FIG. 2A illustrates a transverse cross sectional view of strut 12 of FIG. 2 taken along the line 2 A- 2 A.
- FIG. 2B illustrates a transverse cross sectional view of strut 12 of FIG. 2 taken along the line 2 B- 2 B.
- segment 16 has a reduced thickness and width, which provides for a smaller circumference, as compared to the remaining portions of strut 12 .
- FIGS. 2, 2A and 2 B illustrate a four-sided strut 12 wherein segment 16 has a reduced width W as well as thickness T.
- Struts 12 need not be four-sided, however, and can have any suitable transverse cross sectional geometry, such as a three sided, oval or circular struts.
- the reduced circumferential size of segment 16 defines a recessed volume 18 in which a coating 20 can be deposited.
- Coating 20 can be a drug or a therapeutic composition or can contain the drug.
- Coating 20 can be made from any suitable biocompatible polymer, examples of which are disclosed below.
- the remaining segments of strut 12 can be free from any substances or coatings.
- Coating 20 can be disposed all the way around segment 16 as coating 20 can completely encapsulate the narrowed segment 16 of strut 12 .
- Recessed volume 18 can be fully filled with the coating substance such that the outer surfaces of coating 20 are “flush” with their respective outer surfaces of strut 12 .
- the outer dimensions of coating 20 can equal the outer dimensions of strut 12 , thereby creating a smooth transition between the surfaces of coating 20 and the surfaces of strut 12 , thus minimizing intravascular flow turbulence around stent 10 .
- strut 12 can have a variable thickness T, but a constant width W. As best illustrated by FIG. 3 , width W of strut 12 is the same, but thickness T is reduced along segment 16 of strut 12 . The reduced thickness T provides recessed volume 18 containing coating 20 on the outer surface or tissue-contacting surface of strut 12 . Although not illustrated, a recessed volume 18 can also be provided in the inner or lumen surface of strut 12 .
- a variable width W for strut 12 can be provided, while maintaining the thickness T constant.
- thickness T of strut is the same, but width W is reduced along segment 16 of strut 12 .
- FIG. 4 illustrates recessed volumes 18 on opposing sides of strut 12 .
- recessed volume 18 can be about only one of the two sides of strut 12 .
- Transition zones leading into segment 16 can be gradual, with a slight slop, as illustrated by FIG. 2 or can be a relatively sharp drop-off, as illustrated by FIG. 3 or 4 .
- the smallest transverse cross sectional area in segment 16 can be up to about 50% smaller than the transverse cross sectional area of the remaining portions of strut 12 .
- One having ordinary skill in the art should be cautious of mechanical fatigue and failure that could be caused if the circumference of segment 16 is too small or if the transition zone is sloped too non-compliant.
- Exemplary dimensions and design of strut 12 depend, of course, on an variety of factors including the material from which strut 12 is made, the length of segment 16 , and the application for which stent 10 will be used. Accordingly, there is a tradeoff between trying to maximize recess volume 18 for maximizing drug delivery capabilities and eliminating mechanical failure that can be caused by radial expansion and use of stent 10 .
- any number of suitable segments 16 having a reduced circumferential area can be included in strut 12 .
- Having a multitude of segments 16 allows for the incorporation of more than one type of therapeutic substance in different areas of stent 10 . Accordingly, a variety of cocktail combinations of drugs can be delivered via stent 10 .
- the longitudinal span of each segment 16 depends on the number of segments 16 that are to be incorporated into strut 12 and the length of strut 12 , among other factors.
- FIG. 6A illustrates strut 12 having a thinned section, in either thickness or width, in the curved portion (as designated by reference number 22 ) of strut 12 .
- notches 24 can be provided in curved portion 22 of strut 12 .
- the thinned section and/or pivot notches 24 in curved portion 22 of strut 12 can produce a weakened bending region for stent 10 .
- the weakened bending region can maximize bending along curved region 22 or at pivot notches 24 and minimize stress along the linear portion of strut 12 . This is advantageous in preserving the structural integrity of coating 20 so as to prevent or reduce fragmentation of coating during the radial expansion of stent 10 .
- Struts 12 can be made from a metallic material or an alloy such as, but not limited to, cobalt chromium alloy (ELGILOY), stainless steel (316L), “MP35N,” “MP20N,” ELASTINITE (nitinol), tantalum, nickel-titanium alloy, platinum-iridium alloy, gold, magnesium, or combinations thereof “MP35N” and “MP20N” are trade names for alloys of cobalt, nickel, chromium and molybdenum available from Standard Press Steel Co., Jenkintown, Pa. “MP35N” consists of 35% cobalt, 35% nickel, 20% chromium, and 10% molybdenum. “MP20N” consists of 50% cobalt, 20% nickel, 20% chromium, and 10% molybdenum. Struts 12 can also be made fiom bioabsorbable or biostable polymers.
- ELGILOY cobalt chromium alloy
- stainless steel 316L
- MP35N stainless steel
- the drug, therapeutic substance or active agent, terms which are used interchangeably, in the coating 20 can inhibit the activity of vascular smooth muscle cells. More specifically, the active agent can be aimed at inhibiting abnormal or inappropriate migration and/or proliferation of smooth muscle cells for the inhibition of restenosis.
- the active agent can also include any substance capable of exerting a therapeutic or prophylactic effect for a diseased condition.
- the agent can be for enhancing wound healing in a vascular site or improving the structural and elastic properties of the vascular site.
- agents include antiproliferative substances such as actinomycin D, or derivatives and analogs thereof (manufactured by Sigma-Aldrich, Inc., Milwaukee, Wis.; or COSMEGEN available from Merck & Co., Inc., Whitehorse Station, N.J.). Synonyms of actinomycin D include dactinomycin, actinomycin IV, actinomycin I l , actinomycin X l , and actinomycin C l .
- the active agent can also fall under the genus of antineoplastic, anti-inflammatory, antiplatelet, anticoagulant, antifibrin, antithrombin, antimitotic, antibiotic, antiallergic and antioxidant substances.
- antineoplastics and/or antimitotics examples include paclitaxel (e.g., TAXOL® by Bristol-Myers Squibb Co., Stamford, Conn.), docetaxel (e.g., Taxotere®, from Aventis S.A., Frankfurt, Germany), methotrexate, azathioprine, vincristine, vinblastine, fluorouracil, doxorubicin hydrochloride (e.g., Adriamycin® from Pharmacia & Upjohn, Peapack, N.J.), and mitomycin (e.g., Mutamycin® from Bristol-Myers Squibb Co.).
- paclitaxel e.g., TAXOL® by Bristol-Myers Squibb Co., Stamford, Conn.
- docetaxel e.g., Taxotere®, from Aventis S.A., Frankfurt, Germany
- methotrexate e.g., azathio
- antiplatelets examples include sodium heparin, low molecular weight heparins, heparinoids, hirudin, argatroban, forskolin, vapiprost, prostacyclin and prostacyclin analogues, dextran, D-phe-pro-arg-chloromethylketone (synthetic antithrombin), dipyridamole, glycoprotein IIb/IIIa platelet membrane receptor antagonist antibody, recombinant hirudin, and thrombin inhibitors such as Angiomax ä (Biogen, Inc., Cambridge, Mass.).
- cytostatic or antiproliferative agents include angiopeptin, angiotensin converting enzyme inhibitors such as captopril (e.g. Capoten® and Capozide® from Bristol-Myers Squibb Co.), cilazapril or lisinopril (e.g., Prinivil® and Prinzide® from Merck & Co., Inc.); calcium channel blockers (such as nifedipine), colchicine, fibroblast growth factor (FGF) antagonists, fish oil (omega 3-fatty acid), histamine antagonists, lovastatin (an inhibitor of HMG-CoA reductase, a cholesterol lowering drug, brand name Mevacor® from Merck & Co., Inc.), monoclonal antibodies (such as those specific for Platelet-Derived Growth Factor (PDGF) receptors), nitroprusside, phosphodiesterase inhibitors, prostaglandin inhibitors, suramin, serotonin blockers, steroids,
- Coating 20 can be made from any suitable biocompatible polymer, examples of which include ethylene vinyl alcohol copolymer (commonly known by the generic name EVOH or by the trade name EVAL); poly(hydroxyvalerate); poly(L-lactic acid); polycaprolactone; poly(lactide-co-glycolide); poly(hydroxybutyrate); poly(hydroxybutyrate-co-valerate); polydioxanone; polyorthoester; polyanhydride; poly(glycolic acid); poly(D,L-lactic acid); poly(glycolic acid-co-trimethylene carbonate); polyphosphoester; polyphosphoester urethane; poly(amino acids); cyanoacrylates; poly(trimethylene carbonate); poly(iminocarbonate); copoly(ether-esters) (e.g., PEO/PLA); polyalkylene oxalates; polyphosphazenes; biomolecules, such as fibrin, fibrinogen, cellulose, starch, collagen
- Stent 10 can be constructed, for example, from a tube of a desired strut material.
- the tube can be mounted onto a mandrel and angular grooves can be cut into the outer surface of the tube by a lathe or a Swiss screw, for example KJR-16Swiss Screw Machine available from STAR CNC Automatic Lathe in Shizuoka, Japan.
- the shape of strut 12 can then be radially cut from the tube by a laser.
- the laser cutting can also produce the thinned curved section 22 or pivot notches 24 illustrated in FIGS. 6A and 6B .
- Struts 12 can be electropolished to reshape or round off sharp comers.
- Stent 10 can then be mounted on a Teflon® or paralyne coated mandrel fixed to a two-dimensional actuator controlled by a computer numerical control (CNC) controller, for example a Model DR500available from Aerotek, Inc., Pittsburgh, Pa.
- CNC computer numerical control
- the two-dimensional actuator can translate and rotate stent 10 about the longitudinal axis of stent 10 .
- a fluid applicator device for example a Model 1500XL available from EFD, Inc., East Buffalo, R.I., with a needle tip, can be fixed adjacent to the mounted stent 10 and ejection of a coating substance can be controlled by the CNC controller.
- the needle tip can have an outer diameter of about 0.02 mm (0.0008in.) to about 0.038 mm (0.0015 in.) and an inner diameter from about 0.005 mm (0.0002 in.) to about 0.02 mm (0.0009 in.).
- the CNC controller then causes ejection of coating 20 in a liquid state from the needle tip into recessed volume 18 and simultaneously moves stent 10 longitudinally to spread coating 20 evenly in recessed volume 18 .
- recessed volume 18 of segment 16 is coated with a desired volume of coating 20
- ejection of the coating substance ceases and stent 10 can be moved until the next uncoated recessed volume 18 is adjacent to the needle tip of the fluid applicator device.
- the process can repeat until all the recessed volumes 18 are coated.
- the needle tip should also be capable of being raised and lowered relative to stent 10 by the CNC controller particularly when coating small volumes necessitates direct contact between the needle tip and stent 10 .
- coating 20 can be deposited in recessed volumes 18 by crimping stent 10 onto a mandrel covered with a soft material (for examples, having a D hardness rating of about 20 to about 50, such as silicon foam, neoprene, santoprene, or a closed cell foam).
- a soft material for examples, having a D hardness rating of about 20 to about 50, such as silicon foam, neoprene, santoprene, or a closed cell foam.
- the soft material can have, for example, a soft material thickness of at least the thickness of strut 12 .
- the mandrel and stent 10 can then be dipped into the coating substance or the coating substance can be sprayed onto stent 10 .
- the mandrel and stent 10 can then be pulled through an orifice with a clearance around strut 12 of less than about 0.003 mm (0.0001 in.), more narrowly less than about 0.001 mm (0.00005 in.). Stent 10 can also be pulled over a reamer to scrape off excess coating substance.
- masking techniques as is known to a person having ordinary skill in the art can be used to deposit coating 20 in recessed volumes 18 of segment 16 .
Abstract
Stents having struts with narrowed portions are described. The narrowed portions have a coating disposed thereon for the local delivery of a drug.
Description
- This is a divisional application of U.S. patent application Ser. No. 10/262,150, which was filed on Sep. 30, 2002.
- This invention relates to implantable medical devices, such as stents. More particularly, this invention relates to a stent having drug delivery capabilities.
- Percutaneous transluminal coronary angioplasty (PTCA) is a procedure for treating heart disease. A catheter assembly having a balloon portion is introduced into the cardiovascular system of a patient via the brachial or femoral artery. The catheter assembly is advanced through the coronary vasculature until the balloon portion is positioned across the occlusive lesion. Once in position across the lesion, the balloon is inflated to a predetermined size to radially compress against the atherosclerotic plaque of the lesion to remodel the lumen wall. The balloon is then deflated to a smaller profile to allow the catheter to be withdrawn from the patient's vasculature.
- A problem associated with the procedure includes formation of intimal flaps or torn arterial linings that can collapse and occlude the conduit after the balloon is deflated. Moreover, thrombosis and restenosis of the artery can develop over several months after the procedure, which can require another angioplasty procedure or a surgical bypass operation. To reduce the partial or total occlusion of the artery by the collapse of arterial lining and to reduce the chance of the development of thrombosis and restenosis, an intraluminal prosthesis, an example of which includes an expandable stent, is implanted in the lumen to maintain the vascular patency. Stents are scaffolding structures, usually cylindrical or tubular in shape, functioning to physically hold open, and if desired, to expand the wall of the passageway. Typically stents are capable of being compressed for insertion through small cavities via small catheters, and then expanded to a larger diameter once at the desired location.
- To treat the damaged vasculature tissue and further fight against thrombosis and restenosis, there is a need to administer therapeutic substances to the treatment site. For example, anticoagulants, antiplatelets and cytostatic agents are commonly used to prevent thrombosis of the coronary lumen, to inhibit development of restenosis, and to reduce post-angioplasty proliferation of the vascular tissue. To provide an efficacious concentration to the treated site, systemic administration of medication can produce adverse or toxic side effects for the patient. Local delivery is a highly suitable method of treatment in that smaller levels of medication, as compared to systemic dosages, are concentrated at a specific site. Local delivery produces fewer side effects and achieves more effective results.
- One commonly applied technique for the local delivery of the drugs is through the use of medicated stents. One method of medicating stents involves the use of a polymeric carrier coated onto the body of the stent. A polymer dissolved in a solvent and a drug added thereto can be applied to the stent. Once the solvent evaporates, a coating of the polymer containing the drug remains on the stent. The embodiments of the present invention provide various stent structures for containing a coating, such as a polymeric coating, for the local delivery of a drug.
- In accordance with one embodiment, a stent is disclosed comprising a strut having a first segment, a second segment and a third segment located between the first and second segments, wherein the transverse cross sectional area of the third segment is less than the transverse cross sectional area of the first segment and the second segment; and a coating disposed on the third segment of the strut, wherein the first and second segments of the strut are free of any coating. In one embodiment, the coating is disposed all the way around the third segment of the strut. The outer surface of the coating should not extend beyond the outer surface of the first or second segment of the strut. The coating can be made from a polymeric material containing a therapeutic substance. In accordance with one embodiment, the strut includes a linear segment extending into a curved segment, wherein the first, second and third segments define a part of the linear segment of the strut. The curved segment can include a notch or can be smaller in thickness or width than the first or second segment of the strut.
- In accordance with another embodiment of the invention, a radially expandable stent is provided comprising a strut, at least a segment of the strut having a circumference smaller than the circumference of a remaining portion of the strut; and a coating supported by the segment of the strut having the smaller circumference. The strut can include four sides, wherein the width of the segment of the strut having the smaller circumference is less than the width of the remaining portion of the strut. Alternatively, the thickness of the segment of the strut having the smaller circumference is less than the thickness of the remaining portion of the strut. The coating can, for example, surround the segment of the strut having the reduced circumference. The remaining portion of the strut having the larger circumference can be free from any coating.
- In accordance with another embodiment of the invention, a method of manufacturing a drug eluting stent is provided, comprising depositing a coating on a first segment of a strut of the stent, the stent including a second segment and a third segment, wherein the first segment is positioned between the second segment and the third segment, the first segment having a smaller transverse cross sectional area than the transverse cross sectional area of the second or third segment.
- In accordance with another embodiment of the invention, a method of manufacturing a drug eluting stent is provided, comprising depositing a coating on a stent, the stent including a strut having a first segment, a second segment, and a third segment located between the first and second segments, wherein the transverse cross sectional area of the third segment is less than the transverse cross sectional area of the first segment and the second segment; and removing the coating off of the first and second segments so that the coating remains on the third segment.
-
FIG. 1 illustrates an embodiment of a conventional stent; -
FIG. 2 is an enlarged perspective view of the stent strut ofencircled region 2 ofFIG. 1 ; -
FIGS. 2A and 2B are transverse cross sectional views along theline 2A-2A and 2B-2B, respectively, ofFIG. 2 ; and -
FIGS. 3, 4 , 5, 6A, and 6B are perspective views of a stent strut according to other embodiments of the invention. -
FIG. 1 illustrates one embodiment of astent 10 that can be used with the practice of the present invention.Stent 10 can be generally cylindrical and radially self- or balloon-expandable. Stent 10 can be inserted and deployed in a patient with an appropriate delivery device such as a balloon dilatation catheter.Stent 10 can be made, for example, from a plurality of wave-like or serpentine-like struts 12 having curved segments and generally linear segments.Struts 12 are connected to theadjacent struts 12 via connectingelements 14. The embodiments of the present invention, however, should not be limited to the structure ofFIG. 1 . A variety of other scaffolding designs can also be used, such as “V” shaped struts or Struts having a “zigzag” formation. - Referring to
FIG. 2 , the linear section ofstrut 12 includes a segment, referred to byreference number 16, wherein any transverse cross sectional portion ofsegment 16 has a smaller cross sectional surface area than the remaining segment ofstrut 12.FIG. 2A illustrates a transverse cross sectional view ofstrut 12 ofFIG. 2 taken along theline 2A-2A.FIG. 2B illustrates a transverse cross sectional view ofstrut 12 ofFIG. 2 taken along theline 2B-2B. As illustrated byFIGS. 2A and 2B ,segment 16 has a reduced thickness and width, which provides for a smaller circumference, as compared to the remaining portions ofstrut 12. -
FIGS. 2, 2A and 2B illustrate a four-sided strut 12 whereinsegment 16 has a reduced width W as well asthickness T. Struts 12 need not be four-sided, however, and can have any suitable transverse cross sectional geometry, such as a three sided, oval or circular struts. The reduced circumferential size ofsegment 16 defines arecessed volume 18 in which acoating 20 can be deposited.Coating 20 can be a drug or a therapeutic composition or can contain the drug.Coating 20 can be made from any suitable biocompatible polymer, examples of which are disclosed below. As best illustrated byFIG. 2 , the remaining segments ofstrut 12 can be free from any substances or coatings.Coating 20 can be disposed all the way aroundsegment 16 as coating 20 can completely encapsulate the narrowedsegment 16 ofstrut 12. Recessedvolume 18 can be fully filled with the coating substance such that the outer surfaces ofcoating 20 are “flush” with their respective outer surfaces ofstrut 12. In other words, the outer dimensions ofcoating 20 can equal the outer dimensions ofstrut 12, thereby creating a smooth transition between the surfaces ofcoating 20 and the surfaces ofstrut 12, thus minimizing intravascular flow turbulence aroundstent 10. - In accordance with another embodiment of the invention, as illustrated in
FIG. 3 , strut 12 can have a variable thickness T, but a constant width W. As best illustrated byFIG. 3 , width W ofstrut 12 is the same, but thickness T is reduced alongsegment 16 ofstrut 12. The reduced thickness T provides recessedvolume 18 containingcoating 20 on the outer surface or tissue-contacting surface ofstrut 12. Although not illustrated, a recessedvolume 18 can also be provided in the inner or lumen surface ofstrut 12. - In accordance with another embodiment, as illustrated by
FIG. 4 , a variable width W forstrut 12 can be provided, while maintaining the thickness T constant. As best illustrated byFIG. 4 , thickness T of strut is the same, but width W is reduced alongsegment 16 ofstrut 12.FIG. 4 illustrates recessedvolumes 18 on opposing sides ofstrut 12. However, as is the case withFIG. 3 , recessedvolume 18 can be about only one of the two sides ofstrut 12. - Transition zones leading into
segment 16 can be gradual, with a slight slop, as illustrated byFIG. 2 or can be a relatively sharp drop-off, as illustrated byFIG. 3 or 4. The smallest transverse cross sectional area insegment 16 can be up to about 50% smaller than the transverse cross sectional area of the remaining portions ofstrut 12. One having ordinary skill in the art should be cautious of mechanical fatigue and failure that could be caused if the circumference ofsegment 16 is too small or if the transition zone is sloped too non-compliant. Exemplary dimensions and design ofstrut 12 depend, of course, on an variety of factors including the material from which strut 12 is made, the length ofsegment 16, and the application for whichstent 10 will be used. Accordingly, there is a tradeoff between trying to maximizerecess volume 18 for maximizing drug delivery capabilities and eliminating mechanical failure that can be caused by radial expansion and use ofstent 10. - In accordance with yet another embodiment, as illustrated in
FIG. 5 , any number ofsuitable segments 16 having a reduced circumferential area can be included instrut 12. Having a multitude ofsegments 16 allows for the incorporation of more than one type of therapeutic substance in different areas ofstent 10. Accordingly, a variety of cocktail combinations of drugs can be delivered viastent 10. The longitudinal span of eachsegment 16 depends on the number ofsegments 16 that are to be incorporated intostrut 12 and the length ofstrut 12, among other factors. - In accordance with yet another embodiment of the invention,
FIG. 6A illustratesstrut 12 having a thinned section, in either thickness or width, in the curved portion (as designated by reference number 22) ofstrut 12. Alternatively, as illustrated inFIG. 6B notches 24 can be provided incurved portion 22 ofstrut 12. The thinned section and/or pivotnotches 24 incurved portion 22 ofstrut 12 can produce a weakened bending region forstent 10. The weakened bending region can maximize bending alongcurved region 22 or atpivot notches 24 and minimize stress along the linear portion ofstrut 12. This is advantageous in preserving the structural integrity ofcoating 20 so as to prevent or reduce fragmentation of coating during the radial expansion ofstent 10. -
Struts 12 can be made from a metallic material or an alloy such as, but not limited to, cobalt chromium alloy (ELGILOY), stainless steel (316L), “MP35N,” “MP20N,” ELASTINITE (nitinol), tantalum, nickel-titanium alloy, platinum-iridium alloy, gold, magnesium, or combinations thereof “MP35N” and “MP20N” are trade names for alloys of cobalt, nickel, chromium and molybdenum available from Standard Press Steel Co., Jenkintown, Pa. “MP35N” consists of 35% cobalt, 35% nickel, 20% chromium, and 10% molybdenum. “MP20N” consists of 50% cobalt, 20% nickel, 20% chromium, and 10% molybdenum.Struts 12 can also be made fiom bioabsorbable or biostable polymers. - The drug, therapeutic substance or active agent, terms which are used interchangeably, in the
coating 20 can inhibit the activity of vascular smooth muscle cells. More specifically, the active agent can be aimed at inhibiting abnormal or inappropriate migration and/or proliferation of smooth muscle cells for the inhibition of restenosis. The active agent can also include any substance capable of exerting a therapeutic or prophylactic effect for a diseased condition. For example, the agent can be for enhancing wound healing in a vascular site or improving the structural and elastic properties of the vascular site. Examples of agents include antiproliferative substances such as actinomycin D, or derivatives and analogs thereof (manufactured by Sigma-Aldrich, Inc., Milwaukee, Wis.; or COSMEGEN available from Merck & Co., Inc., Whitehorse Station, N.J.). Synonyms of actinomycin D include dactinomycin, actinomycin IV, actinomycin Il, actinomycin Xl, and actinomycin Cl. The active agent can also fall under the genus of antineoplastic, anti-inflammatory, antiplatelet, anticoagulant, antifibrin, antithrombin, antimitotic, antibiotic, antiallergic and antioxidant substances. Examples of such antineoplastics and/or antimitotics include paclitaxel (e.g., TAXOL® by Bristol-Myers Squibb Co., Stamford, Conn.), docetaxel (e.g., Taxotere®, from Aventis S.A., Frankfurt, Germany), methotrexate, azathioprine, vincristine, vinblastine, fluorouracil, doxorubicin hydrochloride (e.g., Adriamycin® from Pharmacia & Upjohn, Peapack, N.J.), and mitomycin (e.g., Mutamycin® from Bristol-Myers Squibb Co.). Examples of such antiplatelets, anticoagulants, antifibrin, and antithrombins include sodium heparin, low molecular weight heparins, heparinoids, hirudin, argatroban, forskolin, vapiprost, prostacyclin and prostacyclin analogues, dextran, D-phe-pro-arg-chloromethylketone (synthetic antithrombin), dipyridamole, glycoprotein IIb/IIIa platelet membrane receptor antagonist antibody, recombinant hirudin, and thrombin inhibitors such as Angiomax ä (Biogen, Inc., Cambridge, Mass.). Examples of such cytostatic or antiproliferative agents include angiopeptin, angiotensin converting enzyme inhibitors such as captopril (e.g. Capoten® and Capozide® from Bristol-Myers Squibb Co.), cilazapril or lisinopril (e.g., Prinivil® and Prinzide® from Merck & Co., Inc.); calcium channel blockers (such as nifedipine), colchicine, fibroblast growth factor (FGF) antagonists, fish oil (omega 3-fatty acid), histamine antagonists, lovastatin (an inhibitor of HMG-CoA reductase, a cholesterol lowering drug, brand name Mevacor® from Merck & Co., Inc.), monoclonal antibodies (such as those specific for Platelet-Derived Growth Factor (PDGF) receptors), nitroprusside, phosphodiesterase inhibitors, prostaglandin inhibitors, suramin, serotonin blockers, steroids, thioprotease inhibitors, triazolopyrimidine (a PDGF antagonist), and nitric oxide. An example of an antiallergic agent is permirolast potassium. Other therapeutic substances or agents which may be appropriate include alpha-interferon, genetically engineered epithelial cells, rapamycin and its derivatives and analogs, and dexamethasone. - Coating 20 can be made from any suitable biocompatible polymer, examples of which include ethylene vinyl alcohol copolymer (commonly known by the generic name EVOH or by the trade name EVAL); poly(hydroxyvalerate); poly(L-lactic acid); polycaprolactone; poly(lactide-co-glycolide); poly(hydroxybutyrate); poly(hydroxybutyrate-co-valerate); polydioxanone; polyorthoester; polyanhydride; poly(glycolic acid); poly(D,L-lactic acid); poly(glycolic acid-co-trimethylene carbonate); polyphosphoester; polyphosphoester urethane; poly(amino acids); cyanoacrylates; poly(trimethylene carbonate); poly(iminocarbonate); copoly(ether-esters) (e.g., PEO/PLA); polyalkylene oxalates; polyphosphazenes; biomolecules, such as fibrin, fibrinogen, cellulose, starch, collagen and hyaluronic acid; polyurethanes; silicones; polyesters; polyolefins; polyisobutylene and ethylene-alphaolefin copolymers; acrylic polymers and copolymers; vinyl halide polymers and copolymers, such as polyvinyl chloride; polyvinyl ethers, such as polyvinyl methyl ether; polyvinylidene halides, such as polyvinylidene fluoride and polyvinylidene chloride; polyacrylonitrile; polyvinyl ketones; polyvinyl aromatics, such as polystyrene; polyvinyl esters, such as polyvinyl acetate; copolymers of vinyl monomers with each other and olefins, such as ethylene-methyl methacrylate copolymers, acrylonitrile-styrene copolymers, ABS resins, and ethylene-vinyl acetate copolymers; polyamides, such as Nylon 66 and polycaprolactam; alkyd resins; polycarbonates; polyoxymethylenes; polyinides; polyethers; epoxy resins; polyurethanes; rayon; rayon-triacetate; cellulose; cellulose acetate; cellulose butyrate; cellulose acetate butyrate; cellophane; cellulose nitrate; cellulose propionate; cellulose ethers; and carboxymethyl cellulose.
Coating 20 can also be silicon foam, neoprene, santoprene, or closed cell foam. -
Stent 10 can be constructed, for example, from a tube of a desired strut material. The tube can be mounted onto a mandrel and angular grooves can be cut into the outer surface of the tube by a lathe or a Swiss screw, for example KJR-16Swiss Screw Machine available from STAR CNC Automatic Lathe in Shizuoka, Japan. The shape ofstrut 12 can then be radially cut from the tube by a laser. The laser cutting can also produce the thinnedcurved section 22 orpivot notches 24 illustrated inFIGS. 6A and 6B .Struts 12 can be electropolished to reshape or round off sharp comers. -
Stent 10 can then be mounted on a Teflon® or paralyne coated mandrel fixed to a two-dimensional actuator controlled by a computer numerical control (CNC) controller, for example a Model DR500available from Aerotek, Inc., Pittsburgh, Pa. The two-dimensional actuator can translate and rotatestent 10 about the longitudinal axis ofstent 10. A fluid applicator device, for example a Model 1500XL available from EFD, Inc., East Providence, R.I., with a needle tip, can be fixed adjacent to the mountedstent 10 and ejection of a coating substance can be controlled by the CNC controller. The needle tip can have an outer diameter of about 0.02 mm (0.0008in.) to about 0.038 mm (0.0015 in.) and an inner diameter from about 0.005 mm (0.0002 in.) to about 0.02 mm (0.0009 in.). The CNC controller then causes ejection ofcoating 20 in a liquid state from the needle tip into recessedvolume 18 and simultaneously movesstent 10 longitudinally to spreadcoating 20 evenly in recessedvolume 18. Once recessedvolume 18 ofsegment 16 is coated with a desired volume ofcoating 20, ejection of the coating substance ceases andstent 10 can be moved until the next uncoated recessedvolume 18 is adjacent to the needle tip of the fluid applicator device. The process can repeat until all the recessedvolumes 18 are coated. The needle tip should also be capable of being raised and lowered relative tostent 10 by the CNC controller particularly when coating small volumes necessitates direct contact between the needle tip andstent 10. - Alternatively, coating 20 can be deposited in recessed
volumes 18 by crimpingstent 10 onto a mandrel covered with a soft material (for examples, having a D hardness rating of about 20 to about 50, such as silicon foam, neoprene, santoprene, or a closed cell foam). In a relaxed state, the soft material can have, for example, a soft material thickness of at least the thickness ofstrut 12. The mandrel andstent 10 can then be dipped into the coating substance or the coating substance can be sprayed ontostent 10. The mandrel andstent 10 can then be pulled through an orifice with a clearance aroundstrut 12 of less than about 0.003 mm (0.0001 in.), more narrowly less than about 0.001 mm (0.00005 in.).Stent 10 can also be pulled over a reamer to scrape off excess coating substance. - In accordance with another embodiment of the invention, masking techniques as is known to a person having ordinary skill in the art can be used to deposit
coating 20 in recessedvolumes 18 ofsegment 16. - While particular embodiments of the present invention have been shown and described, it will be obvious to those having ordinary skill in the art that changes and modifications can be made without departing from this invention. Therefore, the appended claims are to encompass within their scope all such changes and modifications as they fall within the true spirit and scope of the invention.
Claims (16)
1. A stent comprising a strut segment including a first recess on an outer surface of the strut and a second recess on an inner surface of the strut, the recesses disposed on opposite sides of the strut segment from each other, wherein the recesses carry a coating substance.
2. The stent of claim 1 , wherein the coating substance includes a polymeric material.
3. The stent of claim 1 , wherein a remaining portion of the strut segment is free from any coating.
4. The stent of claim 1 , wherein the coating substance includes a drug.
5. The stent of claim 1 , wherein the strut segment has a rectangular, triangular, oval or circular cross-sectional shape.
6. The stent of claim 1 , wherein an outer surface of the coating substance does not extend beyond the surface of the strut segment.
7. A method of manufacturing a stent, comprising depositing a coating on a stent, the stent including a strut segment having a First recess on an outer surface of the strut and a second recess on an inner surface of the strut, the recesses disposed on opposite sides of the strut segment from each other.
8. The method of claim 7 , wherein the coating includes a polymeric material.
9. The method of claim 7 , wherein a remaining portion of the strut segment is free from any coating.
10. The method of claim 7 , wherein the coating includes a drug.
11. The method of claim 7 , wherein the strut segment has a rectangular, triangular, oval or circular cross-sectional shape.
12. The method of claim 7 , wherein an outer surface of the coating does not extend beyond the surface of the strut segment.
13. A method of manufacturing a stent, comprising:
depositing a coating on a stent, the stent including a strut having a first segment, a second segment and a third segment located between the first and second segments, wherein the transverse cross-sectional area of the third segment is less than the transverse cross-sectional area of the first segment and the second segment, and wherein the strut includes a linear segment extending into a curved or bent segment, the first, second and third segments defining a part of the linear segment of the strut, wherein the curved or bent segment includes a notch carved out from the surface of the strut; and
removing the coating off of the first and second segments so that the coating remains on the third segment.
14. The method of claim 13 , wherein the coating includes a drug.
15. The method of claim 13 , wherein the strut has a rectangular, triangular, oval or circular cross-sectional shape.
16. The method of claim 13 , wherein an outer surface of the coating does not extend beyond an outer surface of the strut.
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---|---|---|---|---|
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Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
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US8088060B2 (en) | 2000-03-15 | 2012-01-03 | Orbusneich Medical, Inc. | Progenitor endothelial cell capturing with a drug eluting implantable medical device |
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US6764505B1 (en) | 2001-04-12 | 2004-07-20 | Advanced Cardiovascular Systems, Inc. | Variable surface area stent |
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US20050208093A1 (en) | 2004-03-22 | 2005-09-22 | Thierry Glauser | Phosphoryl choline coating compositions |
US20060079956A1 (en) * | 2004-09-15 | 2006-04-13 | Conor Medsystems, Inc. | Bifurcation stent with crushable end and method for delivery of a stent to a bifurcation |
US9107899B2 (en) | 2005-03-03 | 2015-08-18 | Icon Medical Corporation | Metal alloys for medical devices |
US7540995B2 (en) | 2005-03-03 | 2009-06-02 | Icon Medical Corp. | Process for forming an improved metal alloy stent |
ES2764992T3 (en) | 2005-04-04 | 2020-06-05 | Flexible Stenting Solutions Inc | Flexible stent |
US20070055352A1 (en) * | 2005-09-07 | 2007-03-08 | Wendy Naimark | Stent with pockets for containing a therapeutic agent |
US20070135896A1 (en) * | 2005-12-13 | 2007-06-14 | Robert Burgermeister | Polymeric stent having modified molecular structures in the flexible connectors and the radial struts of the hoops |
US20070135895A1 (en) * | 2005-12-13 | 2007-06-14 | Robert Burgermeister | Polymeric stent having modified molecular structures in both the hoops and selected segments of the flexible connectors |
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US8263103B2 (en) * | 2006-01-31 | 2012-09-11 | Boston Scientific Scimed, Inc. | Medical articles containing biodegradable polymers and acid-neutralizing cationic species |
US20070254003A1 (en) * | 2006-05-01 | 2007-11-01 | Pu Zhou | Non-sticky coatings with therapeutic agents for medical devices |
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US20070288085A1 (en) * | 2006-05-31 | 2007-12-13 | Furst Joseph G | Absorbable medical devices with specific design features |
US8685430B1 (en) | 2006-07-14 | 2014-04-01 | Abbott Cardiovascular Systems Inc. | Tailored aliphatic polyesters for stent coatings |
US7651523B2 (en) * | 2006-07-24 | 2010-01-26 | Cook Incorporated | Intraluminal device with flexible regions |
US8952123B1 (en) | 2006-08-02 | 2015-02-10 | Abbott Cardiovascular Systems Inc. | Dioxanone-based copolymers for implantable devices |
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WO2008088537A2 (en) * | 2006-12-20 | 2008-07-24 | Boston Scientific Limited | Stent with a coating for delivering a therapeutic agent |
US20080175882A1 (en) * | 2007-01-23 | 2008-07-24 | Trollsas Mikael O | Polymers of aliphatic thioester |
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US8974514B2 (en) * | 2007-03-13 | 2015-03-10 | Abbott Cardiovascular Systems Inc. | Intravascular stent with integrated link and ring strut |
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US10155881B2 (en) * | 2007-05-30 | 2018-12-18 | Abbott Cardiovascular Systems Inc. | Substituted polycaprolactone for coating |
US9737638B2 (en) * | 2007-06-20 | 2017-08-22 | Abbott Cardiovascular Systems, Inc. | Polyester amide copolymers having free carboxylic acid pendant groups |
US7927621B2 (en) * | 2007-06-25 | 2011-04-19 | Abbott Cardiovascular Systems Inc. | Thioester-ester-amide copolymers |
US20090004243A1 (en) | 2007-06-29 | 2009-01-01 | Pacetti Stephen D | Biodegradable triblock copolymers for implantable devices |
US7988723B2 (en) | 2007-08-02 | 2011-08-02 | Flexible Stenting Solutions, Inc. | Flexible stent |
GB0717481D0 (en) * | 2007-09-07 | 2007-10-17 | Angiomed Ag | Self-expansible stent with radiopaque markers |
US9814553B1 (en) | 2007-10-10 | 2017-11-14 | Abbott Cardiovascular Systems Inc. | Bioabsorbable semi-crystalline polymer for controlling release of drug from a coating |
EP3505142B1 (en) | 2007-10-19 | 2020-10-28 | CeloNova Biosciences, Inc. | Implantable and lumen-supporting stents |
US20090104241A1 (en) * | 2007-10-23 | 2009-04-23 | Pacetti Stephen D | Random amorphous terpolymer containing lactide and glycolide |
US20090110713A1 (en) * | 2007-10-31 | 2009-04-30 | Florencia Lim | Biodegradable polymeric materials providing controlled release of hydrophobic drugs from implantable devices |
US8642062B2 (en) | 2007-10-31 | 2014-02-04 | Abbott Cardiovascular Systems Inc. | Implantable device having a slow dissolving polymer |
US7833266B2 (en) | 2007-11-28 | 2010-11-16 | Boston Scientific Scimed, Inc. | Bifurcated stent with drug wells for specific ostial, carina, and side branch treatment |
US7972373B2 (en) * | 2007-12-19 | 2011-07-05 | Advanced Technologies And Regenerative Medicine, Llc | Balloon expandable bioabsorbable stent with a single stress concentration region interconnecting adjacent struts |
US9370437B2 (en) * | 2007-12-26 | 2016-06-21 | Cook Medical Technologies Llc | Stent having less invasive ends |
US20090186068A1 (en) * | 2008-01-18 | 2009-07-23 | Chameleon Scientific Corporation | Atomic plasma deposited coatings for drug release |
ES2371380T3 (en) * | 2008-01-24 | 2011-12-30 | Boston Scientific Scimed, Inc. | STENT TO SUPPLY A THERAPEUTIC AGENT FROM A SIDE SURFACE OF A STENT STEM. |
WO2009108716A2 (en) | 2008-02-27 | 2009-09-03 | University Of Louisville Research Foundation | Synthetic peptides |
US8128983B2 (en) | 2008-04-11 | 2012-03-06 | Abbott Cardiovascular Systems Inc. | Coating comprising poly(ethylene glycol)-poly(lactide-glycolide-caprolactone) interpenetrating network |
US20090297584A1 (en) * | 2008-04-18 | 2009-12-03 | Florencia Lim | Biosoluble coating with linear over time mass loss |
US8916188B2 (en) | 2008-04-18 | 2014-12-23 | Abbott Cardiovascular Systems Inc. | Block copolymer comprising at least one polyester block and a poly (ethylene glycol) block |
US8114151B2 (en) * | 2008-05-08 | 2012-02-14 | Boston Scientific Scimed, Inc. | Stent with tabs and holes for drug delivery |
US8697113B2 (en) | 2008-05-21 | 2014-04-15 | Abbott Cardiovascular Systems Inc. | Coating comprising a terpolymer comprising caprolactone and glycolide |
US7951193B2 (en) | 2008-07-23 | 2011-05-31 | Boston Scientific Scimed, Inc. | Drug-eluting stent |
US9149376B2 (en) | 2008-10-06 | 2015-10-06 | Cordis Corporation | Reconstrainable stent delivery system |
US20100100170A1 (en) * | 2008-10-22 | 2010-04-22 | Boston Scientific Scimed, Inc. | Shape memory tubular stent with grooves |
CN101732114B (en) * | 2008-11-04 | 2014-07-30 | 上海微创医疗器械(集团)有限公司 | Coronary artery stent with medicine carrying grooves |
US8697110B2 (en) * | 2009-05-14 | 2014-04-15 | Abbott Cardiovascular Systems Inc. | Polymers comprising amorphous terpolymers and semicrystalline blocks |
US8398916B2 (en) | 2010-03-04 | 2013-03-19 | Icon Medical Corp. | Method for forming a tubular medical device |
WO2013156871A2 (en) | 2012-04-17 | 2013-10-24 | University College Dublin, National University Of Ireland, Dublin | Thromboxane receptor antagonists |
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US9486559B2 (en) * | 2013-05-07 | 2016-11-08 | Abbott Cardiovascular Systems Inc. | Methods of treatment with a bioresorbable scaffold for neurologic drug delivery |
CN106535826A (en) | 2014-06-24 | 2017-03-22 | 怡康医疗股份有限公司 | Improved metal alloys for medical devices |
US9381103B2 (en) * | 2014-10-06 | 2016-07-05 | Abbott Cardiovascular Systems Inc. | Stent with elongating struts |
US9932304B2 (en) | 2015-06-16 | 2018-04-03 | University College Dublin, National University Of Ireland, Dublin | Thromboxane receptor antagonists |
WO2017151548A1 (en) | 2016-03-04 | 2017-09-08 | Mirus Llc | Stent device for spinal fusion |
US10849769B2 (en) * | 2017-08-23 | 2020-12-01 | Vesper Medical, Inc. | Non-foreshortening stent |
Citations (44)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4459252A (en) * | 1975-05-09 | 1984-07-10 | Macgregor David C | Method of forming a small bore flexible vascular graft involving eluting solvent-elutable particles from a polymeric tubular article |
US5059211A (en) * | 1987-06-25 | 1991-10-22 | Duke University | Absorbable vascular stent |
US5163952A (en) * | 1990-09-14 | 1992-11-17 | Michael Froix | Expandable polymeric stent with memory and delivery apparatus and method |
US5282823A (en) * | 1992-03-19 | 1994-02-01 | Medtronic, Inc. | Intravascular radially expandable stent |
US5342348A (en) * | 1992-12-04 | 1994-08-30 | Kaplan Aaron V | Method and device for treating and enlarging body lumens |
US5425739A (en) * | 1989-03-09 | 1995-06-20 | Avatar Design And Development, Inc. | Anastomosis stent and stent selection system |
US5464650A (en) * | 1993-04-26 | 1995-11-07 | Medtronic, Inc. | Intravascular stent and method |
US5514154A (en) * | 1991-10-28 | 1996-05-07 | Advanced Cardiovascular Systems, Inc. | Expandable stents |
US5527337A (en) * | 1987-06-25 | 1996-06-18 | Duke University | Bioabsorbable stent and method of making the same |
US5569295A (en) * | 1993-12-28 | 1996-10-29 | Advanced Cardiovascular Systems, Inc. | Expandable stents and method for making same |
US5605696A (en) * | 1995-03-30 | 1997-02-25 | Advanced Cardiovascular Systems, Inc. | Drug loaded polymeric material and method of manufacture |
US5629077A (en) * | 1994-06-27 | 1997-05-13 | Advanced Cardiovascular Systems, Inc. | Biodegradable mesh and film stent |
US5700286A (en) * | 1994-12-13 | 1997-12-23 | Advanced Cardiovascular Systems, Inc. | Polymer film for wrapping a stent structure |
US5713949A (en) * | 1996-08-06 | 1998-02-03 | Jayaraman; Swaminathan | Microporous covered stents and method of coating |
US5722984A (en) * | 1996-01-16 | 1998-03-03 | Iso Stent, Inc. | Antithrombogenic radioactive coating for an intravascular stent |
US5769883A (en) * | 1991-10-04 | 1998-06-23 | Scimed Life Systems, Inc. | Biodegradable drug delivery vascular stent |
US5843172A (en) * | 1997-04-15 | 1998-12-01 | Advanced Cardiovascular Systems, Inc. | Porous medicated stent |
US5855600A (en) * | 1997-08-01 | 1999-01-05 | Inflow Dynamics Inc. | Flexible implantable stent with composite design |
US5873904A (en) * | 1995-06-07 | 1999-02-23 | Cook Incorporated | Silver implantable medical device |
US5891108A (en) * | 1994-09-12 | 1999-04-06 | Cordis Corporation | Drug delivery stent |
US5972027A (en) * | 1997-09-30 | 1999-10-26 | Scimed Life Systems, Inc | Porous stent drug delivery system |
US5980972A (en) * | 1996-12-20 | 1999-11-09 | Schneider (Usa) Inc | Method of applying drug-release coatings |
US6042606A (en) * | 1997-09-29 | 2000-03-28 | Cook Incorporated | Radially expandable non-axially contracting surgical stent |
US6071305A (en) * | 1996-11-25 | 2000-06-06 | Alza Corporation | Directional drug delivery stent and method of use |
US6120847A (en) * | 1999-01-08 | 2000-09-19 | Scimed Life Systems, Inc. | Surface treatment method for stent coating |
US6120536A (en) * | 1995-04-19 | 2000-09-19 | Schneider (Usa) Inc. | Medical devices with long term non-thrombogenic coatings |
US6129755A (en) * | 1998-01-09 | 2000-10-10 | Nitinol Development Corporation | Intravascular stent having an improved strut configuration |
US6171334B1 (en) * | 1998-06-17 | 2001-01-09 | Advanced Cardiovascular Systems, Inc. | Expandable stent and method of use |
US6203569B1 (en) * | 1996-01-04 | 2001-03-20 | Bandula Wijay | Flexible stent |
US6206915B1 (en) * | 1998-09-29 | 2001-03-27 | Medtronic Ave, Inc. | Drug storing and metering stent |
US6254632B1 (en) * | 2000-09-28 | 2001-07-03 | Advanced Cardiovascular Systems, Inc. | Implantable medical device having protruding surface structures for drug delivery and cover attachment |
US6273908B1 (en) * | 1997-10-24 | 2001-08-14 | Robert Ndondo-Lay | Stents |
US6273913B1 (en) * | 1997-04-18 | 2001-08-14 | Cordis Corporation | Modified stent useful for delivery of drugs along stent strut |
US6273910B1 (en) * | 1999-03-11 | 2001-08-14 | Advanced Cardiovascular Systems, Inc. | Stent with varying strut geometry |
US6287628B1 (en) * | 1999-09-03 | 2001-09-11 | Advanced Cardiovascular Systems, Inc. | Porous prosthesis and a method of depositing substances into the pores |
US6299604B1 (en) * | 1998-08-20 | 2001-10-09 | Cook Incorporated | Coated implantable medical device |
US6355063B1 (en) * | 2000-01-20 | 2002-03-12 | Impra, Inc. | Expanded PTFE drug delivery graft |
US6379381B1 (en) * | 1999-09-03 | 2002-04-30 | Advanced Cardiovascular Systems, Inc. | Porous prosthesis and a method of depositing substances into the pores |
US6395326B1 (en) * | 2000-05-31 | 2002-05-28 | Advanced Cardiovascular Systems, Inc. | Apparatus and method for depositing a coating onto a surface of a prosthesis |
US6416543B1 (en) * | 1997-06-20 | 2002-07-09 | Cathnet-Science S.A. | Expandable stent with variable thickness |
US6506437B1 (en) * | 2000-10-17 | 2003-01-14 | Advanced Cardiovascular Systems, Inc. | Methods of coating an implantable device having depots formed in a surface thereof |
US6551353B1 (en) * | 1997-10-28 | 2003-04-22 | Hills, Inc. | Synthetic fibers for medical use and method of making the same |
US6887266B2 (en) * | 2002-11-14 | 2005-05-03 | Synecor, Llc | Endoprostheses and methods of manufacture |
US6979347B1 (en) * | 2000-10-23 | 2005-12-27 | Advanced Cardiovascular Systems, Inc. | Implantable drug delivery prosthesis |
Family Cites Families (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU4191989A (en) | 1988-08-24 | 1990-03-23 | Marvin J. Slepian | Biodegradable polymeric endoluminal sealing |
CA2026604A1 (en) * | 1989-10-02 | 1991-04-03 | Rodney G. Wolff | Articulated stent |
IT1276342B1 (en) | 1993-06-04 | 1997-10-30 | Ist Naz Stud Cura Dei Tumori | METAL STENT COVERED WITH BIOCOMPATIBLE POLYMERIC MATERIAL |
DE69510986T2 (en) * | 1994-04-25 | 1999-12-02 | Advanced Cardiovascular System | Radiation-opaque stent markings |
US6783543B2 (en) | 2000-06-05 | 2004-08-31 | Scimed Life Systems, Inc. | Intravascular stent with increasing coating retaining capacity |
US6174329B1 (en) * | 1996-08-22 | 2001-01-16 | Advanced Cardiovascular Systems, Inc. | Protective coating for a stent with intermediate radiopaque coating |
US6086611A (en) * | 1997-09-25 | 2000-07-11 | Ave Connaught | Bifurcated stent |
US7208010B2 (en) * | 2000-10-16 | 2007-04-24 | Conor Medsystems, Inc. | Expandable medical device for delivery of beneficial agent |
JPH11299901A (en) | 1998-04-16 | 1999-11-02 | Johnson & Johnson Medical Kk | Stent and its manufacture |
WO2000000238A1 (en) | 1998-06-26 | 2000-01-06 | Quanam Medical Corporation | Topoisomerase inhibitors for prevention of restenosis |
CA2376069A1 (en) | 1999-06-30 | 2001-01-04 | Orlando M. Padilla | Variable thickness stent and method of manufacture thereof |
US6540774B1 (en) * | 1999-08-31 | 2003-04-01 | Advanced Cardiovascular Systems, Inc. | Stent design with end rings having enhanced strength and radiopacity |
WO2001091918A1 (en) | 2000-05-31 | 2001-12-06 | Advanced Cardiovascular Systems, Inc. | An apparatus and method for forming a coating onto a surface of a prosthesis |
US6764507B2 (en) * | 2000-10-16 | 2004-07-20 | Conor Medsystems, Inc. | Expandable medical device with improved spatial distribution |
US6605110B2 (en) * | 2001-06-29 | 2003-08-12 | Advanced Cardiovascular Systems, Inc. | Stent with enhanced bendability and flexibility |
-
2002
- 2002-09-30 US US10/262,150 patent/US7135038B1/en not_active Expired - Lifetime
-
2006
- 2006-10-10 US US11/546,203 patent/US20070032856A1/en not_active Abandoned
Patent Citations (47)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4459252A (en) * | 1975-05-09 | 1984-07-10 | Macgregor David C | Method of forming a small bore flexible vascular graft involving eluting solvent-elutable particles from a polymeric tubular article |
US5306286A (en) * | 1987-06-25 | 1994-04-26 | Duke University | Absorbable stent |
US5059211A (en) * | 1987-06-25 | 1991-10-22 | Duke University | Absorbable vascular stent |
US5527337A (en) * | 1987-06-25 | 1996-06-18 | Duke University | Bioabsorbable stent and method of making the same |
US5425739A (en) * | 1989-03-09 | 1995-06-20 | Avatar Design And Development, Inc. | Anastomosis stent and stent selection system |
US5163952A (en) * | 1990-09-14 | 1992-11-17 | Michael Froix | Expandable polymeric stent with memory and delivery apparatus and method |
US5769883A (en) * | 1991-10-04 | 1998-06-23 | Scimed Life Systems, Inc. | Biodegradable drug delivery vascular stent |
US5514154A (en) * | 1991-10-28 | 1996-05-07 | Advanced Cardiovascular Systems, Inc. | Expandable stents |
US5603721A (en) * | 1991-10-28 | 1997-02-18 | Advanced Cardiovascular Systems, Inc. | Expandable stents and method for making same |
US5282823A (en) * | 1992-03-19 | 1994-02-01 | Medtronic, Inc. | Intravascular radially expandable stent |
US5342348A (en) * | 1992-12-04 | 1994-08-30 | Kaplan Aaron V | Method and device for treating and enlarging body lumens |
US5464650A (en) * | 1993-04-26 | 1995-11-07 | Medtronic, Inc. | Intravascular stent and method |
US5569295A (en) * | 1993-12-28 | 1996-10-29 | Advanced Cardiovascular Systems, Inc. | Expandable stents and method for making same |
US5766710A (en) * | 1994-06-27 | 1998-06-16 | Advanced Cardiovascular Systems, Inc. | Biodegradable mesh and film stent |
US5629077A (en) * | 1994-06-27 | 1997-05-13 | Advanced Cardiovascular Systems, Inc. | Biodegradable mesh and film stent |
US5891108A (en) * | 1994-09-12 | 1999-04-06 | Cordis Corporation | Drug delivery stent |
US5700286A (en) * | 1994-12-13 | 1997-12-23 | Advanced Cardiovascular Systems, Inc. | Polymer film for wrapping a stent structure |
US5605696A (en) * | 1995-03-30 | 1997-02-25 | Advanced Cardiovascular Systems, Inc. | Drug loaded polymeric material and method of manufacture |
US6120536A (en) * | 1995-04-19 | 2000-09-19 | Schneider (Usa) Inc. | Medical devices with long term non-thrombogenic coatings |
US5873904A (en) * | 1995-06-07 | 1999-02-23 | Cook Incorporated | Silver implantable medical device |
US6203569B1 (en) * | 1996-01-04 | 2001-03-20 | Bandula Wijay | Flexible stent |
US5722984A (en) * | 1996-01-16 | 1998-03-03 | Iso Stent, Inc. | Antithrombogenic radioactive coating for an intravascular stent |
US5713949A (en) * | 1996-08-06 | 1998-02-03 | Jayaraman; Swaminathan | Microporous covered stents and method of coating |
US6071305A (en) * | 1996-11-25 | 2000-06-06 | Alza Corporation | Directional drug delivery stent and method of use |
US5980972A (en) * | 1996-12-20 | 1999-11-09 | Schneider (Usa) Inc | Method of applying drug-release coatings |
US5843172A (en) * | 1997-04-15 | 1998-12-01 | Advanced Cardiovascular Systems, Inc. | Porous medicated stent |
US6273913B1 (en) * | 1997-04-18 | 2001-08-14 | Cordis Corporation | Modified stent useful for delivery of drugs along stent strut |
US6416543B1 (en) * | 1997-06-20 | 2002-07-09 | Cathnet-Science S.A. | Expandable stent with variable thickness |
US5855600A (en) * | 1997-08-01 | 1999-01-05 | Inflow Dynamics Inc. | Flexible implantable stent with composite design |
US6042606A (en) * | 1997-09-29 | 2000-03-28 | Cook Incorporated | Radially expandable non-axially contracting surgical stent |
US5972027A (en) * | 1997-09-30 | 1999-10-26 | Scimed Life Systems, Inc | Porous stent drug delivery system |
US6273908B1 (en) * | 1997-10-24 | 2001-08-14 | Robert Ndondo-Lay | Stents |
US6551353B1 (en) * | 1997-10-28 | 2003-04-22 | Hills, Inc. | Synthetic fibers for medical use and method of making the same |
US6129755A (en) * | 1998-01-09 | 2000-10-10 | Nitinol Development Corporation | Intravascular stent having an improved strut configuration |
US6171334B1 (en) * | 1998-06-17 | 2001-01-09 | Advanced Cardiovascular Systems, Inc. | Expandable stent and method of use |
US6299604B1 (en) * | 1998-08-20 | 2001-10-09 | Cook Incorporated | Coated implantable medical device |
US6206915B1 (en) * | 1998-09-29 | 2001-03-27 | Medtronic Ave, Inc. | Drug storing and metering stent |
US6120847A (en) * | 1999-01-08 | 2000-09-19 | Scimed Life Systems, Inc. | Surface treatment method for stent coating |
US6273910B1 (en) * | 1999-03-11 | 2001-08-14 | Advanced Cardiovascular Systems, Inc. | Stent with varying strut geometry |
US6287628B1 (en) * | 1999-09-03 | 2001-09-11 | Advanced Cardiovascular Systems, Inc. | Porous prosthesis and a method of depositing substances into the pores |
US6379381B1 (en) * | 1999-09-03 | 2002-04-30 | Advanced Cardiovascular Systems, Inc. | Porous prosthesis and a method of depositing substances into the pores |
US6355063B1 (en) * | 2000-01-20 | 2002-03-12 | Impra, Inc. | Expanded PTFE drug delivery graft |
US6395326B1 (en) * | 2000-05-31 | 2002-05-28 | Advanced Cardiovascular Systems, Inc. | Apparatus and method for depositing a coating onto a surface of a prosthesis |
US6254632B1 (en) * | 2000-09-28 | 2001-07-03 | Advanced Cardiovascular Systems, Inc. | Implantable medical device having protruding surface structures for drug delivery and cover attachment |
US6506437B1 (en) * | 2000-10-17 | 2003-01-14 | Advanced Cardiovascular Systems, Inc. | Methods of coating an implantable device having depots formed in a surface thereof |
US6979347B1 (en) * | 2000-10-23 | 2005-12-27 | Advanced Cardiovascular Systems, Inc. | Implantable drug delivery prosthesis |
US6887266B2 (en) * | 2002-11-14 | 2005-05-03 | Synecor, Llc | Endoprostheses and methods of manufacture |
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US7655033B2 (en) * | 2004-12-09 | 2010-02-02 | Med Institute, Inc. | S-shaped stent design |
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US11357624B2 (en) | 2007-04-13 | 2022-06-14 | Jenavalve Technology, Inc. | Medical device for treating a heart valve insufficiency |
US8119151B2 (en) * | 2007-04-20 | 2012-02-21 | Boston Scientific Scimed, Inc. | Spread coating a medical device |
US20080260936A1 (en) * | 2007-04-20 | 2008-10-23 | Matt Heidner | Spread coating a medical device |
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US10993805B2 (en) | 2008-02-26 | 2021-05-04 | Jenavalve Technology, Inc. | Stent for the positioning and anchoring of a valvular prosthesis in an implantation site in the heart of a patient |
US9439759B2 (en) | 2008-02-26 | 2016-09-13 | Jenavalve Technology, Inc. | Endoprosthesis for implantation in the heart of a patient |
US9987133B2 (en) | 2008-02-26 | 2018-06-05 | Jenavalve Technology, Inc. | Stent for the positioning and anchoring of a valvular prosthesis in an implantation site in the heart of a patient |
US10154901B2 (en) | 2008-02-26 | 2018-12-18 | Jenavalve Technology, Inc. | Stent for the positioning and anchoring of a valvular prosthesis in an implantation site in the heart of a patient |
US8790395B2 (en) | 2008-02-26 | 2014-07-29 | Jenavalve Technology Gmbh | Stent for the positioning and anchoring of a valvular prosthesis in an implantation site in the heart of a patient |
US11564794B2 (en) | 2008-02-26 | 2023-01-31 | Jenavalve Technology, Inc. | Stent for the positioning and anchoring of a valvular prosthesis in an implantation site in the heart of a patient |
US20110208290A1 (en) * | 2008-02-26 | 2011-08-25 | Helmut Straubinger | Stent for the positioning and anchoring of a valvular prosthesis in an implantation site in the heart of a patient |
US10702382B2 (en) | 2008-02-26 | 2020-07-07 | Jenavalve Technology, Inc. | Stent for the positioning and anchoring of a valvular prosthesis in an implantation site in the heart of a patient |
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US8465540B2 (en) * | 2008-02-26 | 2013-06-18 | Jenavalve Technology, Inc. | Stent for the positioning and anchoring of a valvular prosthesis |
US20100100177A1 (en) * | 2008-10-20 | 2010-04-22 | Advanced Medical Optics, Inc. | Multifocal Intraocular Lens |
US9744031B2 (en) | 2010-05-25 | 2017-08-29 | Jenavalve Technology, Inc. | Prosthetic heart valve and endoprosthesis comprising a prosthetic heart valve and a stent |
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