US20050288766A1 - Devices and methods for controlling expandable prostheses during deployment - Google Patents
Devices and methods for controlling expandable prostheses during deployment Download PDFInfo
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- US20050288766A1 US20050288766A1 US10/879,949 US87994904A US2005288766A1 US 20050288766 A1 US20050288766 A1 US 20050288766A1 US 87994904 A US87994904 A US 87994904A US 2005288766 A1 US2005288766 A1 US 2005288766A1
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- prostheses
- delivery catheter
- prosthesis
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- deployment
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/95—Instruments specially adapted for placement or removal of stents or stent-grafts
- A61F2/962—Instruments specially adapted for placement or removal of stents or stent-grafts having an outer sleeve
- A61F2/966—Instruments specially adapted for placement or removal of stents or stent-grafts having an outer sleeve with relative longitudinal movement between outer sleeve and prosthesis, e.g. using a push rod
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/95—Instruments specially adapted for placement or removal of stents or stent-grafts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/95—Instruments specially adapted for placement or removal of stents or stent-grafts
- A61F2/962—Instruments specially adapted for placement or removal of stents or stent-grafts having an outer sleeve
- A61F2/97—Instruments specially adapted for placement or removal of stents or stent-grafts having an outer sleeve the outer sleeve being splittable
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/95—Instruments specially adapted for placement or removal of stents or stent-grafts
- A61F2/958—Inflatable balloons for placing stents or stent-grafts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/82—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2002/826—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents more than one stent being applied sequentially
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/95—Instruments specially adapted for placement or removal of stents or stent-grafts
- A61F2002/9505—Instruments specially adapted for placement or removal of stents or stent-grafts having retaining means other than an outer sleeve, e.g. male-female connector between stent and instrument
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/95—Instruments specially adapted for placement or removal of stents or stent-grafts
- A61F2002/9505—Instruments specially adapted for placement or removal of stents or stent-grafts having retaining means other than an outer sleeve, e.g. male-female connector between stent and instrument
- A61F2002/9511—Instruments specially adapted for placement or removal of stents or stent-grafts having retaining means other than an outer sleeve, e.g. male-female connector between stent and instrument the retaining means being filaments or wires
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/95—Instruments specially adapted for placement or removal of stents or stent-grafts
- A61F2/958—Inflatable balloons for placing stents or stent-grafts
- A61F2002/9583—Means for holding the stent on the balloon, e.g. using protrusions, adhesives or an outer sleeve
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/95—Instruments specially adapted for placement or removal of stents or stent-grafts
- A61F2/962—Instruments specially adapted for placement or removal of stents or stent-grafts having an outer sleeve
- A61F2/966—Instruments specially adapted for placement or removal of stents or stent-grafts having an outer sleeve with relative longitudinal movement between outer sleeve and prosthesis, e.g. using a push rod
- A61F2002/9665—Instruments specially adapted for placement or removal of stents or stent-grafts having an outer sleeve with relative longitudinal movement between outer sleeve and prosthesis, e.g. using a push rod with additional retaining means
Definitions
- Stents are tubular prostheses designed for implantation in a vessel to maintain patency of the vessel lumen. Stents are used in various vessels throughout the body, including the coronary arteries, femoral arteries, iliac arteries, renal artery, carotid artery, vascular grafts, biliary ducts, trachea, and urethra, to name some examples. Stents are typically implanted by means of long and flexible delivery catheters that carry the stents in a compact, collapsed shape to the treatment site and then deploy the stents into the vessel. In some applications, balloon expandable stents are used.
- stents are made of a malleable metal such as stainless steel or cobalt chromium and are expanded by means of a balloon on the tip of the delivery catheter to plastically deform the stent into contact with the vessel wall.
- self-expanding stents are used. These are made of a resilient material that can be collapsed into a compact shape for delivery via catheter and that will self-expand into contact with the vessel when deployed from the catheter. Materials commonly used for self-expanding stents include stainless steel and elastic or superelastic alloys such as nickel titanium (NitinolTM).
- stents face a number of challenges.
- One such challenge is that in some cases the disease in a vessel may be so extensive that a stent of very long length, e.g. 30-200 mm, is called for.
- a stent of very long length e.g. 30-200 mm
- Currently available stents are typically less than 30 mm in length, and suffer from excessive stiffness if made longer. Such stiffness is particularly problematic in peripheral vessels such as the femoral arteries, where limb movement requires a high degree of flexibility in any stent implanted in such vessels.
- the problem is particularly acute because as the stent is released from the catheter, its resiliency tends to cause it to eject or “watermelon seed” distally from the catheter tip by an unpredictable distance. During such deployment, the stent may displace not only axially but rotationally relative to the delivery catheter resulting in inaccurate, uncontrollable, and unpredictable stent placement.
- Interleaving stents or stent segments such as those disclosed in co-pending application Ser. No. 10/738,666, filed Dec. 16, 2003, which is incorporated herein by reference, present even greater challenges to conventional delivery systems.
- Interleaving stents have axially extending elements on each end of the stent that interleave with similar structures on an adjacent stent. Such interleaving minimizes the gap between adjacent stents and increases vessel wall coverage to ensure adequate scaffolding and minimize protrusion of plaque from the vessel wall.
- interleaving requires that the relative rotational as well as axial positions of the adjacent stents be maintained during deployment to avoid metal overlap and excessive gaps between stents.
- Conventional delivery systems suffer from the inability to control both the axial and rotational positions of self-expanding stents as they are deployed.
- the stents and stent delivery systems should facilitate stenting of long vascular regions of various lengths without requiring the use of multiple catheters. Such stents and delivery systems should also provide sufficient flexibility for use in peripheral vessels and other regions where long and highly flexible stents might be required. In addition, the stents and stent delivery systems should enable the delivery of multiple stents of various lengths to one or more treatment sites using a single catheter without requiring catheter exchanges.
- the stents and stent delivery systems should facilitate accurate and repeatable control of stent placement and inter-stent spacing to enable deployment of multiple self-expanding stents end-to-end in a vessel at generally constant spacing and without overlap.
- the stents and delivery systems should enable the deployment of interleaving stents or stent segments with precision and control over both the axial spacing and rotational position of each stent or segment.
- the present invention provides prostheses, prosthesis delivery systems, and methods of prosthesis deployment that enable the precise and controllable delivery of multiple prostheses using a single delivery catheter.
- the prostheses, delivery systems, and methods of the invention provide for the precise control of prosthesis placement so that inter-prosthesis spacing is maintained at a constant and optimum distance.
- both axial and rotational displacement of the prostheses relative to the delivery catheter is controlled during deployment, enabling the delivery of multiple prostheses that interleave with one another without overlap.
- the prostheses, prosthesis delivery systems, and methods of the invention further enable the length of prostheses to be customized in situ to match the length of the site to be treated.
- the invention is particularly useful for delivery of self-expanding prostheses, but balloon expandable prostheses are also contemplated within the scope of the invention.
- the invention is well-suited to delivery of stents to the coronary arteries and to peripheral vessels such as the popliteal, femoral, tibial, iliac, renal, and carotid arteries.
- the invention is further useful for delivery of prostheses to other vessels including biliary, neurologic, urinary, reproductive, intestinal, pulmonary, and others, as well as for delivery of other types of prostheses to various anatomical regions, wherever precise control of prosthesis deployment is desirable.
- a prosthesis delivery catheter in a first aspect of the invention, includes an outer shaft having a first lumen; a plurality of self-expanding tubular prostheses carried within the first lumen, the prostheses being adapted to radially expand upon deployment from the first lumen; a deployment mechanism for deploying a selected number of the prostheses from the first lumen; and a control member interactive with the prostheses to control expansion of the prostheses when the prostheses are deployed from the first lumen.
- the control member may comprise a plurality of axially-extending wires, the prostheses being coupled to the wires and axially slidable thereon, the wires being radially deflectable to allow controlled expansion of the prostheses.
- the wires may have free distal ends configured to move radially outward as the prostheses expand. The distal ends of the wires may be retractable into the outer shaft following deployment of the selected number of prostheses.
- the prostheses may have sidewalls with a plurality of openings, the wires being threaded through the openings.
- the wires may form a loop extending around the outside of the prostheses and through the inside of the prostheses, wherein the wires can be withdrawn from around the prostheses following deployment thereof. In such case, at least one end of each wire is releasable to allow the wire to be withdrawn following prosthesis deployment.
- the delivery catheter may further comprise an inner shaft disposed in the first lumen, the prostheses being slidably disposed around the inner shaft, wherein a distal end of each wire is releasably coupled to the inner shaft.
- a nosecone may be attached to the inner shaft distally of the prostheses, the distal end of each wire being releasably coupled to the nosecone.
- the inner shaft may also have an inner lumen and at least one port in communication with the inner lumen, wherein the control wires are slidably disposed through the inner lumen and the port.
- the control member may also comprise a sleeve disposed around the prostheses, the sleeve being expandable to allow controlled expansion of the prostheses.
- the sleeve may be elastomeric, an expandable mesh or woven material, or other expandable structure. When expanded, the sleeve may form a cone shape that flares in the distal direction.
- the sleeve may be slidable relative to the outer shaft.
- the sleeve may have at least one longitudinal slit therein whereby it expands by splitting at the longitudinal slit.
- the sleeve may have a pair of opposing edges bordering the longitudinal slit, a cone shape being formed by moving the edges at an angle relative to each other.
- the sleeve may also have a plurality of longitudinal sections or beams separated by longitudinal slits, the longitudinal sections being deflectable outwardly to allow controlled expansion of the prostheses.
- a retainer may be releasably coupled to the longitudinal sections to selectively prevent radial deflection thereof.
- the retainer may comprise a capsule coupled to an inner shaft slidably disposed through the first lumen, longitudinal sections being received in the capsule.
- the deployment mechanism of the delivery catheter may comprise a pushing element slidably disposed in the first lumen, the pushing element being in engagement with at least one of the prostheses to advance the prostheses distally relative to the outer shaft.
- the prostheses are self-expandable, made of resilient or shape memory materials such as stainless steel, Nitinol or suitable polymers. Such self-expanding prostheses are held in an unexpanded state within the outer shaft until deployed therefrom, whereupon they resiliently expand to an expanded shape in contact with the vessel wall or lesion.
- the delivery systems of the invention will also be useful with balloon expandable prostheses. In either case, expandable balloons, valve members, and other mechanisms may also be included in the delivery catheter to facilitate stent deployment.
- the prostheses are releasably interconnected to each other.
- the control member may comprise an interconnection structure on the pushing element, the interconnection structure being releasably coupled to at least one of the prostheses to resist distal movement of the prostheses relative to the outer shaft.
- control member of the delivery catheter is preferably configured to maintain rotational position of the prostheses relative to each other. This facilitates the delivery of stents having axially interleaving elements and prevents excessive spacing or overlap between such elements
- a prosthesis delivery catheter for delivering prostheses into a vessel lumen comprises an outer shaft having a first lumen; a plurality of self-expanding tubular prostheses carried within the first lumen, the prostheses being adapted to radially expand upon deployment from the first lumen; a deployment mechanism for deploying a selected number of the prostheses from the first lumen; and an anchor member adapted to engage the vessel to limit movement of the outer shaft relative thereto when a prosthesis is being deployed.
- the anchor member comprises an expandable member mounted on an inner shaft, the inner shaft being slidably disposed in the first lumen.
- the expandable member preferably comprises a balloon.
- the expandable member may be configured to expand within a deployed prosthesis in the vessel lumen.
- the expandable member is preferably configured to remain expanded within the deployed prosthesis while a second prosthesis is deployed adjacent to the deployed prosthesis. This maintains the relative positions of the deployed prosthesis and the delivery catheter so the second prosthesis is deployed at a predictable distance from the deployed prosthesis.
- a prosthesis delivery catheter for delivering prostheses into a vessel lumen comprises an outer shaft having a first lumen; a plurality of self-expanding tubular prostheses carried within the first lumen, the prostheses being adapted to radially expand upon deployment from the first lumen, each prosthesis comprising a distal portion and proximal portion, the distal portion being configured to expand into engagement with the vessel while the proximal portion is at least partially disposed in the first lumen; and a deployment mechanism for deploying a selected number of the prostheses from the first lumen.
- the distal portion is configured to engage the vessel prior to deployment of the proximal portion so that the prosthesis remains in a generally constant position relative to the catheter as the proximal portion is deployed.
- the distal and proximal portions of the prostheses are interconnected by at least one spring member, the spring member having a retracted shape and an elongated shape and being biased into the retracted shape, wherein deployment of the distal portion into the vessel elongates the spring into the elongated shape.
- the deployment of the proximal portion into the vessel allows the spring to return at least partially to the retracted shape to draw the proximal portion toward the distal portion.
- the invention provides a method of delivering one or more prostheses to a treatment site in a vessel comprising positioning a delivery catheter at the treatment site, the delivery catheter carrying a plurality of self-expanding prostheses; selecting a desired number of the prostheses to deploy; deploying the desired number of prostheses from the delivery catheter into the vessel, each prosthesis expanding into contact with the vessel upon deployment; and controlling the axial displacement of each of the selected number of prostheses relative to the delivery catheter during the deployment thereof.
- the axial displacement is controlled by an expandable sleeve disposed around the desired number of prostheses.
- the method may further include retracting the sleeve from around the prostheses after the prostheses have been deployed.
- the axial displacement may also be controlled by a plurality of wires coupled with the desired number of prostheses. The wires may be threaded through openings in each of the prostheses, and may be retracted from the prostheses after the prostheses have been deployed.
- the method may further include controlling the rotational displacement of the selected number of prostheses relative to the delivery catheter and/or relative to each other during the deployment thereof.
- the axial displacement of the prostheses may be controlled by expanding an expandable member in the vessel during deployment of at least a portion of the desired number of prostheses.
- the axial displacement may be controlled by first expanding a distal portion of a first of the prostheses into engagement with the vessel while a proximal portion of the first of the prostheses remains in the delivery catheter, then expanding the proximal portion of the first of the prostheses into engagement with the vessel.
- the prostheses may be releasably interconnected while in the delivery catheter, wherein the axial displacement is controlled by connecting at least one of the prostheses to a restraining member in the delivery catheter. In this case, the selected number of prostheses becomes detached from the prostheses remaining in the delivery catheter upon deployment.
- FIG. 1 is a side cut-away view of a prosthesis delivery catheter according to the invention.
- FIG. 2A is a side cross-sectional view of a distal portion of a prosthesis delivery catheter according to the invention in a further embodiment thereof.
- FIG. 2B is a side cross-sectional view of the prosthesis delivery catheter of FIG. 2A showing the deployment of prostheses in a vessel.
- FIGS. 3A-3C are perspective, side, and end views respectively of a prosthesis coupled to control wires according to further embodiments of the invention.
- FIG. 4A is a side cross-section of a distal portion of a prosthesis delivery catheter according to the invention in a further embodiment thereof.
- FIG. 4B is a side cross-section of the prosthesis delivery catheter of FIG. 4A showing the deployment of prostheses in a vessel.
- FIG. 5 A is a side cross-section of a distal portion of a prosthesis delivery catheter according to the invention in a further embodiment thereof.
- FIG. 5B is an oblique view of a distal portion of a prosthesis delivery catheter according to the invention in yet another embodiment thereof.
- FIGS. 6A-6C are side cross-sectional views of a distal portion of a prosthesis delivery catheter according to the invention in still another embodiment thereof, showing the outer shaft unretracted, outer shaft retracted with sleeve unexpanded, and sleeve with stents expanded, respectively.
- FIGS. 7A-7B are side cross-sectional views of a distal portion of a prosthesis delivery catheter according to the invention in another embodiment thereof, showing outer shaft retracted with sleeve unexpanded, and outer shaft retracted with sleeve and stents expanded, respectively.
- FIGS. 8A-8C are side cross-sectional views of a distal portion of a prosthesis delivery catheter according to the invention in a further embodiment thereof, showing the outer shaft unretracted, outer shaft retracted with sleeve unexpanded, and sleeve with stents expanded, respectively.
- FIGS. 9A-9B are side cross-sectional views of a distal portion of a prosthesis delivery catheter in a vessel according to the invention in another embodiment thereof, showing outer shaft retracted with prosthesis partially deployed, and prosthesis fully deployed, respectively.
- FIGS. 10A-10B are side cross-sectional views of a distal portion of a prosthesis delivery catheter in a vessel according to the invention in yet another embodiment thereof, showing outer shaft retracted with prosthesis partially deployed, and prosthesis fully deployed, respectively.
- FIGS. 11A-11C are side cross-sectional views of a distal portion of a prosthesis delivery catheter in a vessel according to the invention in yet another embodiment thereof, showing a first prosthesis deployed, an expandable member expanded within the first prosthesis, and a second stent deployed with expandable member expanded in the first prosthesis, respectively.
- FIGS. 11D-11F are side cross-sectional views of a distal portion of a prosthesis delivery catheter according to the invention in another embodiment thereof, showing the delivery catheter prior to stent deployment, the deployment of a first prosthesis in a vessel, and a deployed prosthesis in the vessel, respectively.
- FIG. 12 is a side cross-sectional view of a distal portion of a prosthesis delivery catheter in a vessel according to the invention in still another embodiment thereof, showing a first prosthesis deployed in a lesion.
- Delivery catheter 20 may have any of various constructions, including that described in co-pending application Ser. No. 10/637,713, filed Aug. 8, 2003 (Attorney Docket No. 21629-000340), which is incorporated herein by reference.
- Delivery catheter 20 has a handle assembly 21 and an elongated catheter body 22 that includes three concentric tubular shafts all axially slidable relative to one another: an outer shaft 24 , a pusher 26 , and an inner shaft 28 .
- Pusher 26 has a distal extension 27 to which a pusher ring 29 is fixed.
- a guidewire tube 30 extends slidably through a port 32 in outer shaft 24 and through pusher ring 29 and has a distal end 34 , to which is mounted a nosecone 36 and a stop member 38 .
- Delivery catheter 20 further includes one or more stent expansion control members, which in the illustrated embodiment comprise a plurality of control wires 40 .
- control wires 40 Preferably, one or more pairs of control wires 40 are mounted on opposing sides of delivery catheter 20 , e.g. four control wires 40 offset 90° from each other. Control wires 40 are fixed at their proximal ends 42 to inner shaft 28 , and have free distal ends 44 .
- Outer shaft 24 has a distal extremity 46 defining a first lumen 48 .
- a plurality of stents 50 are disposed in a collapsed configuration within first lumen 48 .
- Stents 50 are preferably composed of a resilient material such as stainless steel or Nitinol so as to self-expand from the collapsed configuration to a radially expanded configuration when deployed from first lumen 48 .
- stents 50 as illustrated have a wave-like or undulating pattern in a plurality of interconnected circumferential members, the pattern illustrated is merely exemplary and the stents of the invention may have any of a variety of strut shapes, patterns, and geometries. From 2 up to 10 or more stents may be carried by outer shaft 24 .
- a valve member 49 is mounted within first lumen 48 to facilitate separating those stents 50 to be deployed from those to remain within outer shaft 24 , as described in co-pending application Ser. No. 10/412,714, filed Apr. 10, 2003, which is incorporated herein by reference.
- Control wires 40 run along the outside of stents 50 or through the interior of stents 50 , are threaded through openings in the walls of stents 50 or are otherwise coupled with stents 50 to control the deployment thereof, as described more fully below.
- Control wires 40 are composed of a resilient material such as stainless steel, Nitinol, or a suitable polymer, and are preferably generally straight and biased inwardly against guidewire tube 32 or to a position generally parallel to the axial direction.
- outer shaft 24 has been retracted to expose a plurality of stents 50 which are partially expanded and remain coupled to or restrained by control wires 40 , as explained in greater detail below.
- Handle assembly 21 has a rotatable retraction knob 52 coupled to a shaft housing 53 , to which outer shaft 24 is fixed. By rotating retraction knob 52 , outer shaft 24 may be retracted proximally relative to pusher 26 and inner shaft 28 .
- a pull ring 54 is coupled to inner shaft 28 , allowing inner shaft 28 , and hence control wires 40 , to be retracted proximally relative to outer shaft 24 .
- a switch 56 engages and disengages pusher 26 with outer shaft 28 , so that pusher 26 either moves with outer shaft 24 or remains stationary as outer shaft 24 is retracted.
- Indicia 58 on shaft housing 53 indicate the extent of retraction of outer shaft 28 by distance, number of stents, or other suitable measure.
- handle assembly 21 Other aspects of handle assembly 21 are described in co-pending application Ser. No. 10/746466, filed Dec. 23, 2003 (Attorney Docket No. 21629-002200), which is incorporated herein by reference. Except as stated otherwise, any of the embodiments of the stent delivery catheter described below may incorporate the features and be otherwise constructed as just described.
- FIGS. 2A-2B illustrate a distal extremity of a stent delivery catheter 60 according to the invention in a further embodiment thereof.
- stents 62 have a series of diamond shaped openings 64 in the walls thereof through which a plurality of control wires 66 are threaded.
- Stents 62 have a plurality of axially-extending V-shaped points 63 on their distal and proximal ends. These points 63 are configured to interleave or nest with the points 63 on the adjacent stent 62 , preferably both in the collapsed and expanded configurations.
- Various suitable interleaving stent geometries are described in co-pending application Ser. No. 10/736,666, filed Dec.
- control wires 66 keep adjacent stents 62 in rotational alignment as they are advanced forward through the catheter and during deployment.
- each control wire 66 is threaded through at least two openings 64 in each stent 62 , one opening 64 a near the distal end of each stent 62 and one opening 64 b near the proximal end of each stent 62 .
- control wires 66 may be threaded through only a single opening 64 or through three or more openings 64 on each stent 62 .
- control wires 66 are threaded so that the distal and proximal ends of stents 64 will expand at a generally uniform rate when released, as described below.
- Control wires 66 are constructed of a resilient and flexible metal or polymer with sufficient stiffness to provide controlled resistance to the expansion of stents 62 . This stiffness may be selected to allow the desired expansion behavior of stents 62 such that “watermelon seeding” is avoided, inter-stent spacing is maintained, and sufficient stent expansion occurs. Control wires 66 may have various cross-sectional geometries, and may be a flat ribbons or blades, round or oval wires, I-beams, or other suitable structures to control stent expansion, maintain spacing and rotational position, and facilitate withdrawal from stents 62 without interference.
- Control wires 66 may be composed of or coated with a lubricious material such as PTFE to reduce friction during removal from stents 62 .
- control wires 66 may have surface features, be wrapped with wire windings, or be coated with “sticky” material to increase friction with stents 62 . Coatings or surface structures such as scales with one-way frictional effects may also be applied to control wires 66 .
- control wires 66 may comprise flexible hollow tubes which are pneumatically or hydraulically controllable to vary their rigidity or stiffness.
- control wires 66 may comprise polymeric tubes that radially contract or flatten and are very flexible when evacuated of fluid, but which become more rigid when filled with pressurized fluid, such as saline, air, or other liquid or gas.
- control wires 66 are fluidly connected to a pump, syringe, or other suitable fluid delivery mechanism at the proximal end of the delivery catheter. In this way, control wires 66 may be pressurized to increase stiffness as stents 62 are deployed, then evacuated of fluid to reduce their profile and stiffness during withdrawal from the deployed stents.
- Stents 62 are slidably positioned over an inner shaft 68 , to which is attached a nosecone 70 at the distal end of the device.
- An outer shaft 72 is slidably disposed over inner shaft 68 and surrounds stents 62 , maintaining them in a collapsed configuration, as shown in FIG. 2A .
- a pusher shaft 74 is slidably disposed over inner shaft 68 and is configured to engage the proximal end of the proximal-most stent 62 .
- Outer shaft 72 is retractable relative to inner shaft 68 in order to expose a desired number of stents 62 as shown in FIG. 2B .
- the exposed stents 62 self-expand to a larger-diameter expanded shape in engagement with lesion L in vessel V.
- at least the distal end of the distal-most stent 62 and more preferably a substantial portion of all stents 62 being deployed, is allowed to expand into engagement with lesion L while control wires 66 remain threaded through openings 64 .
- Control wires 66 are then withdrawn from openings 62 , preferably by holding catheter 60 in position and pulling control wires 66 proximally using a suitable mechanism such as that described above with reference to FIG. 1 .
- the entire catheter 60 may be retracted proximally relative to stents 62 to withdraw control wires 66 from openings 62 . Because at least a portion of stents 62 is in engagement with lesion L, stents 62 are held in position in the vessel as control wires 66 are withdrawn.
- inner shaft 68 may have a balloon 76 mounted thereto near its distal end to enable pre- or post-dilatation of lesion L.
- inner shaft 68 has an inflation lumen through which inflation fluid may be delivered to balloon 76 .
- Balloon 76 is preferably as long as the longest lesion that might be treated using catheter 60 .
- outer shaft 72 and those of stents 62 remaining therein are retracted relative to inner shaft 68 to expose a desired length of balloon 76 . The exposed portion of balloon 76 may then be inflated within the lesion L and/or the deployed stents 62 .
- inner shaft 68 is retracted into outer shaft 72 while maintaining pressure against pusher shaft 74 . This slides stents 62 distally along control wires 66 and repositions stents 62 to the distal end of inner shaft 68 so as to be ready for deployment. Catheter 60 may then be repositioned to another vascular location for deployment of additional stents 62 .
- Control wires 66 may be coupled to stents 62 in various ways, some of which depend upon the configuration of stents 62 .
- the points 63 at the ends of each stent 62 may be bent inwardly such that a portion of the openings 64 ′ are oriented axially. Control wires 66 may then be threaded through these axially-oriented openings 64 ′.
- points 63 are adapted to deform with stent expansion so as to be more parallel to the axial direction, thereby providing a smooth and open flow path through the stent.
- stents 80 have axially-aligned eyelets 82 through which control wires 84 are threaded. These eyelets 82 may be in the interior of stents 82 as shown in FIG. 3C , or such eyelets may be on the exterior surface of stents 82 , or could be drilled through one or more of the struts of stents 82 .
- Various other structures may also be used for coupling the stents of the invention to control wires, including hooks, channels, holes, sleeves, and others, disposed on the interior, exterior or end surfaces of the stent, or through the struts themselves.
- Such structures may by integral with stent struts and of the same material, may be attached to the stent struts and be of same or different material, or may be a biodegradable material that erodes and eventually is absorbed into the body following deployment.
- a stent delivery catheter 90 has an outer shaft 92 slidably disposed over an inner shaft 94 , and at least one stent 96 (shown schematically in FIG. 4A ) in a collapsed shape within outer shaft 92 .
- a plurality of control wires 97 have an outer extremity 98 outside of inner shaft 94 and an inner extremity 100 extending through one or more lumens 102 and distal ports 103 in inner shaft 94 . Both outer portion 98 and inner portion 100 extend proximally to the proximal end of delivery catheter 90 .
- Outer extremities 98 are threaded through openings in the wall of stent 96 or are otherwise coupled thereto as described above so as to resist expansion of stent 96 upon deployment.
- Control wires 97 thus form a continuous loop from the proximal end of stent delivery catheter 90 , through stent 96 and back to the proximal end of the catheter.
- FIG. 4B illustrates this embodiment of delivery catheter 90 positioned in a vessel V and carrying plurality of stents 96 ′.
- Stents 96 ′ have axial projections 104 at their distal and proximal ends configured to interleave when stents 96 ′ are collapsed within outer shaft 92 and when deployed in vessel V.
- outer shaft 92 is retracted to expose one or more stents 96 ′
- the expansion of stents 96 ′ can be resisted and controlled by maintaining tension on control wires 97 .
- Tension may be controllably relaxed to allow stents 96 ′ to expand into contact with lesion L, as shown in FIG. 4B .
- each control wire 97 may be released at the proximal end of delivery catheter 90 while the other end is pulled to retract the control wires from stents 96 ′.
- control wires 110 are releasably coupled to the distal end of an inner shaft 112 or to nose cone 114 .
- control wires 110 have balls 116 at their distal ends configured to be received within slots 118 on the outer surface of nosecone 114 ( FIG. 5A ) or on the proximal face of nosecone 114 ( FIG. 5B ; outer shaft not shown for clarity).
- Slots 118 have an enlarged portion 120 of sufficient size to receive ball 116 and a narrow portion 122 through which balls 116 may not pass.
- Inner shaft 112 is axially rotatable relative to control wires 110 .
- control wires 110 may resist expansion of stent 124 .
- Stent 124 may be allowed to expand by gradually relaxing tension on control wires 110 . Once stent 124 is fully expanded tension on control wires 110 may be fully relaxed and nosecone 114 then rotated by rotating inner shaft 112 , thereby allowing balls 116 to pass through enlarged portions 120 . Control wires 110 may then be withdrawn from the deployed stent 124 . Nosecone 114 is then retracted or control wires 110 advanced so as to reinsert balls 116 into slots 118 . Nosecone 114 is then rotated to align balls 116 with narrow portions 122 , again securing the control wires to nosecone 114 . Delivery catheter 108 may then be repositioned to deploy additional stents.
- delivery catheter 108 may include a middle shaft or balloon 126 over which stents 124 are positioned, as shown in FIG. 5A .
- inner shaft 112 is slidably and rotatably disposed in an inner lumen though middle shaft or balloon 126 . If a balloon is included, it may be used for pre-dilatation of lesions prior to stent deployment, or for further expansion of stent 124 following deployment.
- control wires 110 will be constructed to have sufficient stiffness to resist rotation, twisting or bending as nosecone 114 is rotated to release control wires 110 . Maintaining some tension on control wires 110 as nosecone 114 is rotated may facilitate the release process.
- control wires 110 will have sufficient column strength to facilitate reinsertion into slots 118 following deployment of stents 124 . Thus the size, material and geometry of control wires 110 will be selected to enable these actions while providing the desired level of control of stent expansion.
- an expandable sleeve 130 is slidably positioned within outer shaft 132 and carries stents 134 as shown in FIGS. 6 A-C.
- a pusher shaft 136 is slidable within sleeve 130 and engages the proximal-most stent 134 .
- An inner shaft 138 extends through pusher shaft 136 and has a nosecone 140 fixed to its distal end.
- Sleeve 130 may be a tube constructed of a resilient deformable material such as urethane or other medical grade elastomer, or may be a tubular mesh, cage, grating, or other suitable structure of flexible and resilient polymer or metal such as stainless steel or Nitinol.
- the elasticity and stiffness of sleeve 130 are selected to allow stents 134 to expand at the desired rate when deployed from outer shaft 132 without excessive axial or rotational displacement relative to each other or to outer shaft 132 .
- Sleeve 130 is resiliently biased toward an unexpanded shape so that following stent deployment, sleeve 130 returns to a generally tubular shape.
- Outer shaft 132 is constructed of a material with sufficient radial strength and stiffness to resist expansion of stents 134 and sleeve 130 , and may include a metallic or polymeric braid, ribs, rings or other structural reinforcement near its distal end for such purpose.
- the interior surface of sleeve 130 optionally may have surface features such as bumps, scales, bristles, ribs, or roughness to enhance friction with stents 134 .
- These features may be configured to have a grain such that they provide more friction against movement in the distal direction than in the proximal direction, or vice versa. Further, such features may be adapted to provide more friction when sleeve 130 is in an unexpanded shape than when it is expanded by stents 134 .
- bristles may be provided that point more in the proximal direction when sleeve 130 is in its unexpanded cylindrical shape, but which point more distally or radially (perpendicular to the surface of sleeve 130 ) when sleeve 130 is expanded. This allows sleeve 130 to be more easily withdrawn from stents 134 when stents 134 are deployed.
- delivery catheter 129 In order to deploy stents 134 , delivery catheter 129 is positioned across a vascular lesion so that nosecone 140 is disposed just distally of the distal end of the lesion. Outer shaft 132 is then retracted to expose the desired number of stents 134 (and the associated length of sleeve 130 ) which will cover the length of the lesion, as shown in FIG. 6B . As outer shaft 132 is retracted, stents 134 are allowed to expand into contact with the lesion as shown in FIG. 6C . Sleeve 130 controls the rate of expansion and maintains the positions of stents 134 so they are deployed precisely at the intended location.
- sleeve 130 may be retracted from between the stents and the lesion until sleeve 130 is again disposed in outer shaft 132 . Pressure is maintained on pusher shaft 136 during this process so that the stents 134 remaining in delivery catheter 129 are advanced to the distal end of sleeve 130 and outer shaft 132 . Delivery catheter 129 may then be repositioned for deployment of additional stents at other locations.
- a delivery catheter 142 may be constructed largely as described in connection with FIGS. 6 A-C, including an outer shaft 144 , an expandable sleeve 146 slidably disposed therein, a pusher shaft 148 , and inner shaft 150 .
- a plurality of stents 152 are carried in expandable sleeve 146 (shown in FIG. 7B ).
- expandable sleeve 146 includes a longitudinal slit 154 in at least a distal extremity thereof.
- sleeve 146 When outer shaft 144 is retracted relative to sleeve 146 , sleeve 146 may be controllably expanded by axially twisting sleeve 146 such that the opposing edges 156 along longitudinal slit 154 pivot away from one another, forming a cone shape ( FIG. 7B ). In this way, the expansion of stents 152 is further controllable after retraction of outer shaft 144 by controlling the rate of twisting of sleeve 146 .
- An actuator may be provided at the proximal end of delivery catheter 142 to control such twisting.
- sleeve 146 may have a helical thread on its outer surface that mates with a complementary thread on the interior of outer shaft 144 such that sleeve 146 is automatically twisted as outer shaft 144 is retracted. As in the embodiment of FIGS. 6 A-C, following stent deployment, sleeve 146 is retracted from the space between the deployed stents and the vessel wall and returned within outer shaft 144 .
- Sleeve 146 may be resiliently biased to return to its unexpanded configuration, or may be manually twisted back to an unexpanded shape by the operator.
- delivery catheter 160 is again constructed much like delivery catheter 129 of FIGS. 6 A-C, including an outer shaft 162 , a slidable expandable sleeve 164 carrying stents 166 , a pusher shaft 168 , and an inner shaft 170 .
- a nosecone 172 is attached to the distal end of inner shaft 170 and has a concavity 174 at its proximal end configured to receive the distal end of sleeve 164 .
- a distal extremity of sleeve 164 includes a plurality of axial slits 176 defining separate deflectable longitudinal beams 178 .
- Sleeve 164 includes at least two, preferably four, and as many as six, eight, or more slits 176 to provide a corresponding number of longitudinal beams 178 .
- Longitudinal beams 178 are resiliently biased into an axial orientation wherein sleeve 164 is generally cylindrical. Longitudinal beams 178 have sufficient stiffness against lateral deflection to resist and control the expansion of stents 166 .
- outer shaft 162 may be retracted to expose the desired number of stents to cover a target lesion without immediate expansion of stents 166 , as shown in FIG. 8B .
- inner shaft 170 may be advanced distally relative to sleeve 164 , releasing longitudinal beams 178 from concavity 174 . This permits longitudinal beams 178 to laterally deflect, allowing stents 166 to expand, as shown in FIG. 8C .
- longitudinal beams 178 may be retracted from between stents 166 and the vessel wall.
- Longitudinal beams 178 then return to their undeflected axial orientation, allowing inner shaft 170 to be retracted so as to return the distal ends of longitudinal beams 178 into concavity 174 .
- Inner shaft 170 and sleeve 164 may then be retracted into outer shaft 162 while maintaining pressure on pusher shaft 168 , thereby advancing additional stents 166 toward the distal end of sleeve 164 for additional deployments.
- FIGS. 9A-9B illustrates a delivery catheter 180 having a plurality of stents 182 disposed in an outer shaft 184 .
- An inner shaft 186 with optional balloon 188 and nosecone 190 extends through outer shaft 184 and stents 182 and is axially movable relative thereto.
- a pusher shaft (not shown) is slidably disposed over inner shaft 186 and engages stents 182 for purposes of deploying stents 182 from outer shaft 186 and repositioning the remaining stents 182 within outer shaft 186 , as in earlier embodiments.
- stents 182 comprise a plurality of struts 191 forming a series of rings 192 interconnected at joints 193 .
- Each ring 192 has a series of closed cells 194 interconnected circumferentially and having an “I” shape in the unexpanded configuration.
- distal ring 192 ′ is configured to expand into engagement with the vessel wall before the entire length of the stent 182 is deployed from outer shaft 184 ( FIG. 9A ).
- distal ring 192 ′ anchors stent 182 in position as the remainder of the stent is deployed ( FIG. 9B ), preventing “watermelon seeding” of the stent from the catheter.
- the axial length of stent 182 , the length of each ring 192 , the number of rings, the stiffness of struts 191 , and the flexibility of joints 193 are all selected to optimize this deployment behavior.
- Each stent 182 has at least two, and preferably four or more rings 192 , each ring being about 2-5 mm in length, giving stent 182 an overall length of at least about 8-20 mm.
- rings 192 are also contemplated within the scope of the invention.
- Lesions longer than each stent 182 may be treated by deploying multiple stents 182 end-to-end.
- each stent 182 can be deployed precisely at a desired spacing from a previously-deployed stent 182 because the distal ring 192 ′ of each stent 182 can be first allowed to expand into engagement with the vessel at the target location, anchoring the stent in position as the remainder is deployed.
- Rings 192 are preferably formed from a common piece of material and are integrally interconnected at joints 193 , making joints 193 relatively rigid. In this embodiment, the majority of flexibility between rings 192 is provided by struts 191 rather than by joints 193 .
- joints 193 may comprise welded connections between rings 192 which are also fairly rigid.
- joints 193 may comprise hinge or spring structures to allow greater deflection between adjacent rings 192 , as exemplified in FIGS. 10A-10B , described below.
- stents 200 are constructed similarly to stents 182 of FIGS. 9A-9B , including a plurality of interconnected rings 202 having I-shaped cells 204 .
- some of rings 202 are interconnected by spring members 206 that may be elongated to increase the distance between rings 202 and that are resiliently biased into a shortened configuration to draw rings 202 toward each other.
- spring members 206 have a wave-like shape and extend from the tip of an axial projection 208 on one ring 202 to a concave portion 210 between axial projections 208 on the adjacent ring 202 .
- stent 200 comprises two pairs of rings 202 , with the rings of each pair interconnected by integral joints 212 as in FIGS. 9 A-B and the pairs of rings 202 being connected to each other by spring members 206 .
- Stents 200 may alternatively include two, three, five, six or more rings 202 , and spring members 206 may interconnect all or only a portion of rings 202 .
- Spring members 206 may be formed of the same or different material as that of rings 202 , depending upon the desired performance characteristics. In addition, spring members 206 may be biodegradable so as to erode and eventually disappear, leaving the adjacent pairs of rings 202 unconnected.
- a delivery catheter 216 has an outer shaft 218 carrying a plurality of stents 220 .
- An inner shaft 222 extends through outer shaft 218 to a nosecone 224 , and a pusher shaft 226 is slidably disposed over inner shaft 222 .
- An anchoring balloon 228 is mounted to inner shaft 222 proximal to nosecone 224 .
- Anchoring balloon 228 has an axial length sufficient to frictionally engage the wall of vessel V and remain stable so as to anchor delivery catheter 216 in place as further described below.
- anchoring balloon 228 has a length about equal to the length of one of stents 220 .
- outer shaft 218 is retracted so that a first stent 220 ′ is released therefrom and expands into engagement with lesion L ( FIG. 11A ).
- Anchoring balloon 228 is then inflated until it engages the interior of stent 220 ′ ( FIG. 11B ). This not only stabilizes delivery catheter 216 , but may be used to further expand stent 220 ′ and/or dilate lesion L to firmly implant stent 220 ′.
- outer shaft 218 is further retracted to release a second stent 220 ′′, which expands into engagement with lesion L ( FIG. 11C ).
- anchoring balloon 228 stabilizes delivery catheter 216 and anchors it in position relative to first stent 220 ′ as second stent 220 ′′ is deployed. Second stent 220 ′′ is thus deployable precisely at the intended spacing and rotational position relative to first stent 220 ′. Anchoring balloon 228 may then be deflated and retracted into outer shaft 218 , with pressure maintained upon pusher shaft 226 to reposition remaining stents 220 at the distal end of inner shaft 222 .
- FIGS. 11D-11F illustrate another embodiment of a delivery catheter 219 in which a plurality of self-expanding stents 221 are slidably disposed over an elongated balloon 223 .
- Balloon 223 preferably has a length as long as the longest lesion that is to be treated with the device, e.g. 50-200 mm.
- a pusher 225 is slidable relative to balloon 223 and has a tubular distal portion 227 disposed over balloon 223 which engages the proximal-most stent 221 P.
- a sheath 229 is slidably disposed over pusher 225 , stents 221 and balloon 223 and maintains stents 221 in a radially contracted configuration.
- moderate pressure is maintained within balloon 223 during deployment of stents 221 so that the balloon expands simultaneously with each stent.
- a first stent 221 A and a distal portion of balloon 223 are exposed.
- moderate inflation pressure in balloon 223 as sheath 220 is retracted the exposed portion of balloon 223 expands with the first stent 221 A, inhibiting distal migration of the stent from delivery catheter 219 .
- One or more additional stents 221 may be deployed by further retraction of sheath 229 , during which balloon 223 remains expanded within first stent 221 anchoring the delivery catheter 219 in position (not shown).
- stents 221 may have any of a variety of different configurations, including having open or closed cells, zig-zag or wave-shaped struts, and/or axially interleaving elements as described above.
- balloon 223 may have surface features or coatings on its periphery that enhance retention of stents 221 thereon.
- Such features may include structures such as scales or protuberances that are activated by pressurization of the balloon so that retention is lessened when the balloon is deflated, but heightened when the balloon is pressurized.
- pressure can optionally be increased in balloon 223 for post-dilation of stents 221 and the target lesion L.
- Balloon 223 is then deflated and retracted within sheath 229 as distal pressure is maintained against pusher 225 , repositioning stents 221 near the distal end of balloon 223 within sheath 229 for deployment at another location, as shown in FIG. 11C .
- the stents in the delivery catheter of the invention may releasably interconnect with one another and/or with the pusher shaft to enable greater control and precision during deployment.
- delivery catheter 230 carries a plurality of stents 232 having a structure much like that described above in connection with FIGS. 9A-9B .
- the axial projections 234 extending distally and proximally from stents 232 are configured to interconnect with concavities 236 on adjacent stents 232 until expanded.
- axial projections 234 have enlarged heads 246 and concavities 236 have necks 248 that retain heads 246 within concavities 236 in the unexpanded configuration.
- Pusher shaft 250 has a distal end 252 having projections 254 and concavities 256 like those of stents 232 , thus being able to interconnect with the proximal-most stent 232 ′.
- the interconnecting structures thereon are configured to separate from the adjacent stent or pusher shaft, thus releasing the deployed stent 232 ′′ from delivery catheter 230 .
- interconnecting structures between adjacent stents and between the stents and the pusher shaft are possible within the scope of the invention, including those described in co-pending application Ser. No. 10/738,666, filed Dec. 16, 2003, which is incorporated herein by reference.
- Such interconnecting structures may also be breakable or frangible to facilitate separation as the stent expands.
- a mechanism such as an expandable balloon or cutting device may be disposed at the distal end of delivery catheter 230 to assist in separating stents 232 upon deployment.
- the interconnections between stents may be different than the interconnection between the proximal-most stent and the pusher shaft.
- the pusher shaft may have hooks, magnets, or other mechanisms suitable for releasably holding and maintaining traction on the proximal end of a stent until it is deployed.
Abstract
Prosthesis delivery devices and methods are provided that enable precise control of prosthesis position during deployment. The prosthesis delivery devices may carry multiple prostheses and include deployment mechanisms for delivery of a selectable number of prostheses. Control mechanisms are provided in the prosthesis delivery devices that control either or both of the axial and rotational positions of the prostheses during deployment. This enables the deployment of multiple prostheses at a target site with precision and predictability, eliminating excessive spacing or overlap between prostheses. In particular embodiments, the prostheses of the invention are deployed in stenotic lesions in coronary or peripheral arteries or in other vascular locations.
Description
- Stents are tubular prostheses designed for implantation in a vessel to maintain patency of the vessel lumen. Stents are used in various vessels throughout the body, including the coronary arteries, femoral arteries, iliac arteries, renal artery, carotid artery, vascular grafts, biliary ducts, trachea, and urethra, to name some examples. Stents are typically implanted by means of long and flexible delivery catheters that carry the stents in a compact, collapsed shape to the treatment site and then deploy the stents into the vessel. In some applications, balloon expandable stents are used. These stents are made of a malleable metal such as stainless steel or cobalt chromium and are expanded by means of a balloon on the tip of the delivery catheter to plastically deform the stent into contact with the vessel wall. In other applications, self-expanding stents are used. These are made of a resilient material that can be collapsed into a compact shape for delivery via catheter and that will self-expand into contact with the vessel when deployed from the catheter. Materials commonly used for self-expanding stents include stainless steel and elastic or superelastic alloys such as nickel titanium (Nitinol™).
- While self-expanding stents have demonstrated promise in various applications, such stents face a number of challenges. One such challenge is that in some cases the disease in a vessel may be so extensive that a stent of very long length, e.g. 30-200 mm, is called for. Currently available stents are typically less than 30 mm in length, and suffer from excessive stiffness if made longer. Such stiffness is particularly problematic in peripheral vessels such as the femoral arteries, where limb movement requires a high degree of flexibility in any stent implanted in such vessels.
- To overcome the stiffness problem, the idea of deploying multiple shorter stents end-to-end has been proposed. However, this approach has suffered from several drawbacks. First, currently available delivery catheters are capable of delivering only a single stent per catheter. In order to place multiple stents, multiple catheters must be inserted, removed and exchanged, heightening risks, lengthening procedure time, raising costs, and causing excessive material waste. In addition, the deployment of multiple stents end-to-end suffers from the inability to accurately control stent placement and the spacing between stents. This results in overlap of adjacent stents and/or excessive space between stents, which is thought to lead to complications such as restenosis, the renarrowing of a vessel following stent placement. With self-expanding stents the problem is particularly acute because as the stent is released from the catheter, its resiliency tends to cause it to eject or “watermelon seed” distally from the catheter tip by an unpredictable distance. During such deployment, the stent may displace not only axially but rotationally relative to the delivery catheter resulting in inaccurate, uncontrollable, and unpredictable stent placement.
- Interleaving stents or stent segments such as those disclosed in co-pending application Ser. No. 10/738,666, filed Dec. 16, 2003, which is incorporated herein by reference, present even greater challenges to conventional delivery systems. Interleaving stents have axially extending elements on each end of the stent that interleave with similar structures on an adjacent stent. Such interleaving minimizes the gap between adjacent stents and increases vessel wall coverage to ensure adequate scaffolding and minimize protrusion of plaque from the vessel wall. However, such interleaving requires that the relative rotational as well as axial positions of the adjacent stents be maintained during deployment to avoid metal overlap and excessive gaps between stents. Conventional delivery systems suffer from the inability to control both the axial and rotational positions of self-expanding stents as they are deployed.
- What are needed, therefore, are stents and stent delivery system that overcome the foregoing problems. In particular, the stents and stent delivery systems should facilitate stenting of long vascular regions of various lengths without requiring the use of multiple catheters. Such stents and delivery systems should also provide sufficient flexibility for use in peripheral vessels and other regions where long and highly flexible stents might be required. In addition, the stents and stent delivery systems should enable the delivery of multiple stents of various lengths to one or more treatment sites using a single catheter without requiring catheter exchanges. Further, the stents and stent delivery systems should facilitate accurate and repeatable control of stent placement and inter-stent spacing to enable deployment of multiple self-expanding stents end-to-end in a vessel at generally constant spacing and without overlap. Moreover, the stents and delivery systems should enable the deployment of interleaving stents or stent segments with precision and control over both the axial spacing and rotational position of each stent or segment.
- The present invention provides prostheses, prosthesis delivery systems, and methods of prosthesis deployment that enable the precise and controllable delivery of multiple prostheses using a single delivery catheter. The prostheses, delivery systems, and methods of the invention provide for the precise control of prosthesis placement so that inter-prosthesis spacing is maintained at a constant and optimum distance. In some embodiments, both axial and rotational displacement of the prostheses relative to the delivery catheter is controlled during deployment, enabling the delivery of multiple prostheses that interleave with one another without overlap. The prostheses, prosthesis delivery systems, and methods of the invention further enable the length of prostheses to be customized in situ to match the length of the site to be treated. The invention is particularly useful for delivery of self-expanding prostheses, but balloon expandable prostheses are also contemplated within the scope of the invention. The invention is well-suited to delivery of stents to the coronary arteries and to peripheral vessels such as the popliteal, femoral, tibial, iliac, renal, and carotid arteries. The invention is further useful for delivery of prostheses to other vessels including biliary, neurologic, urinary, reproductive, intestinal, pulmonary, and others, as well as for delivery of other types of prostheses to various anatomical regions, wherever precise control of prosthesis deployment is desirable.
- In a first aspect of the invention, a prosthesis delivery catheter includes an outer shaft having a first lumen; a plurality of self-expanding tubular prostheses carried within the first lumen, the prostheses being adapted to radially expand upon deployment from the first lumen; a deployment mechanism for deploying a selected number of the prostheses from the first lumen; and a control member interactive with the prostheses to control expansion of the prostheses when the prostheses are deployed from the first lumen.
- The control member may comprise a plurality of axially-extending wires, the prostheses being coupled to the wires and axially slidable thereon, the wires being radially deflectable to allow controlled expansion of the prostheses. The wires may have free distal ends configured to move radially outward as the prostheses expand. The distal ends of the wires may be retractable into the outer shaft following deployment of the selected number of prostheses. The prostheses may have sidewalls with a plurality of openings, the wires being threaded through the openings. The wires may form a loop extending around the outside of the prostheses and through the inside of the prostheses, wherein the wires can be withdrawn from around the prostheses following deployment thereof. In such case, at least one end of each wire is releasable to allow the wire to be withdrawn following prosthesis deployment.
- The delivery catheter may further comprise an inner shaft disposed in the first lumen, the prostheses being slidably disposed around the inner shaft, wherein a distal end of each wire is releasably coupled to the inner shaft. A nosecone may be attached to the inner shaft distally of the prostheses, the distal end of each wire being releasably coupled to the nosecone. The inner shaft may also have an inner lumen and at least one port in communication with the inner lumen, wherein the control wires are slidably disposed through the inner lumen and the port.
- The control member may also comprise a sleeve disposed around the prostheses, the sleeve being expandable to allow controlled expansion of the prostheses. The sleeve may be elastomeric, an expandable mesh or woven material, or other expandable structure. When expanded, the sleeve may form a cone shape that flares in the distal direction. The sleeve may be slidable relative to the outer shaft. The sleeve may have at least one longitudinal slit therein whereby it expands by splitting at the longitudinal slit. The sleeve may have a pair of opposing edges bordering the longitudinal slit, a cone shape being formed by moving the edges at an angle relative to each other. The sleeve may also have a plurality of longitudinal sections or beams separated by longitudinal slits, the longitudinal sections being deflectable outwardly to allow controlled expansion of the prostheses. A retainer may be releasably coupled to the longitudinal sections to selectively prevent radial deflection thereof. The retainer may comprise a capsule coupled to an inner shaft slidably disposed through the first lumen, longitudinal sections being received in the capsule.
- The deployment mechanism of the delivery catheter may comprise a pushing element slidably disposed in the first lumen, the pushing element being in engagement with at least one of the prostheses to advance the prostheses distally relative to the outer shaft. In preferred embodiments, the prostheses are self-expandable, made of resilient or shape memory materials such as stainless steel, Nitinol or suitable polymers. Such self-expanding prostheses are held in an unexpanded state within the outer shaft until deployed therefrom, whereupon they resiliently expand to an expanded shape in contact with the vessel wall or lesion. The delivery systems of the invention will also be useful with balloon expandable prostheses. In either case, expandable balloons, valve members, and other mechanisms may also be included in the delivery catheter to facilitate stent deployment.
- In a further aspect of the invention, the prostheses are releasably interconnected to each other. In this case, the control member may comprise an interconnection structure on the pushing element, the interconnection structure being releasably coupled to at least one of the prostheses to resist distal movement of the prostheses relative to the outer shaft.
- In addition to controlling axial position of the stents relative to the delivery catheter and/or to each other during deployment, the control member of the delivery catheter is preferably configured to maintain rotational position of the prostheses relative to each other. This facilitates the delivery of stents having axially interleaving elements and prevents excessive spacing or overlap between such elements
- In still another aspect of the invention, a prosthesis delivery catheter for delivering prostheses into a vessel lumen comprises an outer shaft having a first lumen; a plurality of self-expanding tubular prostheses carried within the first lumen, the prostheses being adapted to radially expand upon deployment from the first lumen; a deployment mechanism for deploying a selected number of the prostheses from the first lumen; and an anchor member adapted to engage the vessel to limit movement of the outer shaft relative thereto when a prosthesis is being deployed. In one embodiment, the anchor member comprises an expandable member mounted on an inner shaft, the inner shaft being slidably disposed in the first lumen. The expandable member preferably comprises a balloon. The expandable member may be configured to expand within a deployed prosthesis in the vessel lumen. The expandable member is preferably configured to remain expanded within the deployed prosthesis while a second prosthesis is deployed adjacent to the deployed prosthesis. This maintains the relative positions of the deployed prosthesis and the delivery catheter so the second prosthesis is deployed at a predictable distance from the deployed prosthesis.
- In another aspect of the invention, a prosthesis delivery catheter for delivering prostheses into a vessel lumen comprises an outer shaft having a first lumen; a plurality of self-expanding tubular prostheses carried within the first lumen, the prostheses being adapted to radially expand upon deployment from the first lumen, each prosthesis comprising a distal portion and proximal portion, the distal portion being configured to expand into engagement with the vessel while the proximal portion is at least partially disposed in the first lumen; and a deployment mechanism for deploying a selected number of the prostheses from the first lumen. Preferably, the distal portion is configured to engage the vessel prior to deployment of the proximal portion so that the prosthesis remains in a generally constant position relative to the catheter as the proximal portion is deployed.
- In one embodiment, the distal and proximal portions of the prostheses are interconnected by at least one spring member, the spring member having a retracted shape and an elongated shape and being biased into the retracted shape, wherein deployment of the distal portion into the vessel elongates the spring into the elongated shape. In such a case, the deployment of the proximal portion into the vessel allows the spring to return at least partially to the retracted shape to draw the proximal portion toward the distal portion.
- In still another aspect, the invention provides a method of delivering one or more prostheses to a treatment site in a vessel comprising positioning a delivery catheter at the treatment site, the delivery catheter carrying a plurality of self-expanding prostheses; selecting a desired number of the prostheses to deploy; deploying the desired number of prostheses from the delivery catheter into the vessel, each prosthesis expanding into contact with the vessel upon deployment; and controlling the axial displacement of each of the selected number of prostheses relative to the delivery catheter during the deployment thereof.
- In one embodiment, the axial displacement is controlled by an expandable sleeve disposed around the desired number of prostheses. The method may further include retracting the sleeve from around the prostheses after the prostheses have been deployed. The axial displacement may also be controlled by a plurality of wires coupled with the desired number of prostheses. The wires may be threaded through openings in each of the prostheses, and may be retracted from the prostheses after the prostheses have been deployed.
- The method may further include controlling the rotational displacement of the selected number of prostheses relative to the delivery catheter and/or relative to each other during the deployment thereof.
- The axial displacement of the prostheses may be controlled by expanding an expandable member in the vessel during deployment of at least a portion of the desired number of prostheses. Alternatively, the axial displacement may be controlled by first expanding a distal portion of a first of the prostheses into engagement with the vessel while a proximal portion of the first of the prostheses remains in the delivery catheter, then expanding the proximal portion of the first of the prostheses into engagement with the vessel.
- As a further alternative, the prostheses may be releasably interconnected while in the delivery catheter, wherein the axial displacement is controlled by connecting at least one of the prostheses to a restraining member in the delivery catheter. In this case, the selected number of prostheses becomes detached from the prostheses remaining in the delivery catheter upon deployment.
- Further aspects of the nature and advantages of the invention will be apparent from the following detailed description of various embodiments of the invention taken in conjunction with the drawings.
-
FIG. 1 is a side cut-away view of a prosthesis delivery catheter according to the invention. -
FIG. 2A is a side cross-sectional view of a distal portion of a prosthesis delivery catheter according to the invention in a further embodiment thereof. -
FIG. 2B is a side cross-sectional view of the prosthesis delivery catheter ofFIG. 2A showing the deployment of prostheses in a vessel. -
FIGS. 3A-3C are perspective, side, and end views respectively of a prosthesis coupled to control wires according to further embodiments of the invention. -
FIG. 4A is a side cross-section of a distal portion of a prosthesis delivery catheter according to the invention in a further embodiment thereof. -
FIG. 4B is a side cross-section of the prosthesis delivery catheter ofFIG. 4A showing the deployment of prostheses in a vessel. -
FIG. 5 A is a side cross-section of a distal portion of a prosthesis delivery catheter according to the invention in a further embodiment thereof. -
FIG. 5B is an oblique view of a distal portion of a prosthesis delivery catheter according to the invention in yet another embodiment thereof. -
FIGS. 6A-6C are side cross-sectional views of a distal portion of a prosthesis delivery catheter according to the invention in still another embodiment thereof, showing the outer shaft unretracted, outer shaft retracted with sleeve unexpanded, and sleeve with stents expanded, respectively. -
FIGS. 7A-7B are side cross-sectional views of a distal portion of a prosthesis delivery catheter according to the invention in another embodiment thereof, showing outer shaft retracted with sleeve unexpanded, and outer shaft retracted with sleeve and stents expanded, respectively. -
FIGS. 8A-8C are side cross-sectional views of a distal portion of a prosthesis delivery catheter according to the invention in a further embodiment thereof, showing the outer shaft unretracted, outer shaft retracted with sleeve unexpanded, and sleeve with stents expanded, respectively. -
FIGS. 9A-9B are side cross-sectional views of a distal portion of a prosthesis delivery catheter in a vessel according to the invention in another embodiment thereof, showing outer shaft retracted with prosthesis partially deployed, and prosthesis fully deployed, respectively. -
FIGS. 10A-10B are side cross-sectional views of a distal portion of a prosthesis delivery catheter in a vessel according to the invention in yet another embodiment thereof, showing outer shaft retracted with prosthesis partially deployed, and prosthesis fully deployed, respectively. -
FIGS. 11A-11C are side cross-sectional views of a distal portion of a prosthesis delivery catheter in a vessel according to the invention in yet another embodiment thereof, showing a first prosthesis deployed, an expandable member expanded within the first prosthesis, and a second stent deployed with expandable member expanded in the first prosthesis, respectively. -
FIGS. 11D-11F are side cross-sectional views of a distal portion of a prosthesis delivery catheter according to the invention in another embodiment thereof, showing the delivery catheter prior to stent deployment, the deployment of a first prosthesis in a vessel, and a deployed prosthesis in the vessel, respectively. -
FIG. 12 is a side cross-sectional view of a distal portion of a prosthesis delivery catheter in a vessel according to the invention in still another embodiment thereof, showing a first prosthesis deployed in a lesion. - Referring to
FIG. 1 , a first embodiment of a prosthesis delivery catheter according to the invention is illustrated.Delivery catheter 20 may have any of various constructions, including that described in co-pending application Ser. No. 10/637,713, filed Aug. 8, 2003 (Attorney Docket No. 21629-000340), which is incorporated herein by reference.Delivery catheter 20 has ahandle assembly 21 and an elongated catheter body 22 that includes three concentric tubular shafts all axially slidable relative to one another: anouter shaft 24, apusher 26, and aninner shaft 28.Pusher 26 has adistal extension 27 to which apusher ring 29 is fixed. In a distal region of the catheter body 22, aguidewire tube 30 extends slidably through aport 32 inouter shaft 24 and throughpusher ring 29 and has adistal end 34, to which is mounted a nosecone 36 and a stop member 38. -
Delivery catheter 20 further includes one or more stent expansion control members, which in the illustrated embodiment comprise a plurality ofcontrol wires 40. Preferably, one or more pairs ofcontrol wires 40 are mounted on opposing sides ofdelivery catheter 20, e.g. fourcontrol wires 40 offset 90° from each other.Control wires 40 are fixed at their proximal ends 42 toinner shaft 28, and have free distal ends 44. -
Outer shaft 24 has adistal extremity 46 defining afirst lumen 48. A plurality ofstents 50 are disposed in a collapsed configuration withinfirst lumen 48.Stents 50 are preferably composed of a resilient material such as stainless steel or Nitinol so as to self-expand from the collapsed configuration to a radially expanded configuration when deployed fromfirst lumen 48. Whilestents 50 as illustrated have a wave-like or undulating pattern in a plurality of interconnected circumferential members, the pattern illustrated is merely exemplary and the stents of the invention may have any of a variety of strut shapes, patterns, and geometries. From 2 up to 10 or more stents may be carried byouter shaft 24. Optionally, avalve member 49 is mounted withinfirst lumen 48 to facilitate separating thosestents 50 to be deployed from those to remain withinouter shaft 24, as described in co-pending application Ser. No. 10/412,714, filed Apr. 10, 2003, which is incorporated herein by reference. -
Control wires 40 run along the outside ofstents 50 or through the interior ofstents 50, are threaded through openings in the walls ofstents 50 or are otherwise coupled withstents 50 to control the deployment thereof, as described more fully below.Control wires 40 are composed of a resilient material such as stainless steel, Nitinol, or a suitable polymer, and are preferably generally straight and biased inwardly againstguidewire tube 32 or to a position generally parallel to the axial direction. InFIG. 1 ,outer shaft 24 has been retracted to expose a plurality ofstents 50 which are partially expanded and remain coupled to or restrained bycontrol wires 40, as explained in greater detail below. - Handle
assembly 21 has arotatable retraction knob 52 coupled to a shaft housing 53, to whichouter shaft 24 is fixed. By rotatingretraction knob 52,outer shaft 24 may be retracted proximally relative topusher 26 andinner shaft 28. Apull ring 54 is coupled toinner shaft 28, allowinginner shaft 28, and hence controlwires 40, to be retracted proximally relative toouter shaft 24. Aswitch 56 engages and disengagespusher 26 withouter shaft 28, so thatpusher 26 either moves withouter shaft 24 or remains stationary asouter shaft 24 is retracted.Indicia 58 on shaft housing 53 indicate the extent of retraction ofouter shaft 28 by distance, number of stents, or other suitable measure. Other aspects ofhandle assembly 21 are described in co-pending application Ser. No. 10/746466, filed Dec. 23, 2003 (Attorney Docket No. 21629-002200), which is incorporated herein by reference. Except as stated otherwise, any of the embodiments of the stent delivery catheter described below may incorporate the features and be otherwise constructed as just described. -
FIGS. 2A-2B illustrate a distal extremity of astent delivery catheter 60 according to the invention in a further embodiment thereof. In this embodiment,stents 62 have a series of diamond shapedopenings 64 in the walls thereof through which a plurality ofcontrol wires 66 are threaded.Stents 62 have a plurality of axially-extending V-shapedpoints 63 on their distal and proximal ends. Thesepoints 63 are configured to interleave or nest with thepoints 63 on theadjacent stent 62, preferably both in the collapsed and expanded configurations. Various suitable interleaving stent geometries are described in co-pending application Ser. No. 10/736,666, filed Dec. 16, 2003, which is incorporated herein by reference. In order to maintain this interleaving, it is important to maintain the relative rotational and axial positions of theadjacent stents 62 both before and during deployment. By extending through theopenings 64 in each stent,control wires 66 keepadjacent stents 62 in rotational alignment as they are advanced forward through the catheter and during deployment. Preferably, eachcontrol wire 66 is threaded through at least twoopenings 64 in eachstent 62, one opening 64 a near the distal end of eachstent 62 and oneopening 64 b near the proximal end of eachstent 62. Alternatively,control wires 66 may be threaded through only asingle opening 64 or through three ormore openings 64 on eachstent 62. Preferably, however,control wires 66 are threaded so that the distal and proximal ends ofstents 64 will expand at a generally uniform rate when released, as described below. -
Control wires 66 are constructed of a resilient and flexible metal or polymer with sufficient stiffness to provide controlled resistance to the expansion ofstents 62. This stiffness may be selected to allow the desired expansion behavior ofstents 62 such that “watermelon seeding” is avoided, inter-stent spacing is maintained, and sufficient stent expansion occurs.Control wires 66 may have various cross-sectional geometries, and may be a flat ribbons or blades, round or oval wires, I-beams, or other suitable structures to control stent expansion, maintain spacing and rotational position, and facilitate withdrawal fromstents 62 without interference.Control wires 66 may be composed of or coated with a lubricious material such as PTFE to reduce friction during removal fromstents 62. In other embodiments,control wires 66 may have surface features, be wrapped with wire windings, or be coated with “sticky” material to increase friction withstents 62. Coatings or surface structures such as scales with one-way frictional effects may also be applied to controlwires 66. - As a further alternative,
control wires 66 may comprise flexible hollow tubes which are pneumatically or hydraulically controllable to vary their rigidity or stiffness. For example,control wires 66 may comprise polymeric tubes that radially contract or flatten and are very flexible when evacuated of fluid, but which become more rigid when filled with pressurized fluid, such as saline, air, or other liquid or gas. In such an embodiment,control wires 66 are fluidly connected to a pump, syringe, or other suitable fluid delivery mechanism at the proximal end of the delivery catheter. In this way,control wires 66 may be pressurized to increase stiffness asstents 62 are deployed, then evacuated of fluid to reduce their profile and stiffness during withdrawal from the deployed stents. -
Stents 62 are slidably positioned over aninner shaft 68, to which is attached anosecone 70 at the distal end of the device. Anouter shaft 72 is slidably disposed overinner shaft 68 and surroundsstents 62, maintaining them in a collapsed configuration, as shown inFIG. 2A . Apusher shaft 74 is slidably disposed overinner shaft 68 and is configured to engage the proximal end of theproximal-most stent 62.Outer shaft 72 is retractable relative toinner shaft 68 in order to expose a desired number ofstents 62 as shown inFIG. 2B . Whenouter shaft 72 is retracted, the exposedstents 62 self-expand to a larger-diameter expanded shape in engagement with lesion L in vessel V. Preferably, at least the distal end of thedistal-most stent 62, and more preferably a substantial portion of allstents 62 being deployed, is allowed to expand into engagement with lesion L whilecontrol wires 66 remain threaded throughopenings 64.Control wires 66 are then withdrawn fromopenings 62, preferably by holdingcatheter 60 in position and pullingcontrol wires 66 proximally using a suitable mechanism such as that described above with reference toFIG. 1 . Alternatively, theentire catheter 60 may be retracted proximally relative tostents 62 to withdrawcontrol wires 66 fromopenings 62. Because at least a portion ofstents 62 is in engagement with lesion L,stents 62 are held in position in the vessel ascontrol wires 66 are withdrawn. - Optionally,
inner shaft 68 may have aballoon 76 mounted thereto near its distal end to enable pre- or post-dilatation of lesion L. In this embodiment,inner shaft 68 has an inflation lumen through which inflation fluid may be delivered toballoon 76.Balloon 76 is preferably as long as the longest lesion that might be treated usingcatheter 60. To dilate lesion L prior to stent deployment, or to further expandstents 62 after deployment,outer shaft 72 and those ofstents 62 remaining therein are retracted relative toinner shaft 68 to expose a desired length ofballoon 76. The exposed portion ofballoon 76 may then be inflated within the lesion L and/or the deployedstents 62. - Following deployment and any post-dilatation,
inner shaft 68 is retracted intoouter shaft 72 while maintaining pressure againstpusher shaft 74. This slidesstents 62 distally alongcontrol wires 66 and repositionsstents 62 to the distal end ofinner shaft 68 so as to be ready for deployment.Catheter 60 may then be repositioned to another vascular location for deployment ofadditional stents 62. -
Control wires 66 may be coupled tostents 62 in various ways, some of which depend upon the configuration ofstents 62. For example, as shown in FIGS. 3A-B, thepoints 63 at the ends of eachstent 62 may be bent inwardly such that a portion of theopenings 64′ are oriented axially.Control wires 66 may then be threaded through these axially-orientedopenings 64′. Preferably, upon deployment, points 63 are adapted to deform with stent expansion so as to be more parallel to the axial direction, thereby providing a smooth and open flow path through the stent. - In another embodiment, shown in
FIG. 3C ,stents 80 have axially-alignedeyelets 82 through whichcontrol wires 84 are threaded. Theseeyelets 82 may be in the interior ofstents 82 as shown inFIG. 3C , or such eyelets may be on the exterior surface ofstents 82, or could be drilled through one or more of the struts ofstents 82. Various other structures may also be used for coupling the stents of the invention to control wires, including hooks, channels, holes, sleeves, and others, disposed on the interior, exterior or end surfaces of the stent, or through the struts themselves. Such structures may by integral with stent struts and of the same material, may be attached to the stent struts and be of same or different material, or may be a biodegradable material that erodes and eventually is absorbed into the body following deployment. - Referring now to
FIGS. 4A-4B , in a further embodiment, astent delivery catheter 90 has anouter shaft 92 slidably disposed over aninner shaft 94, and at least one stent 96 (shown schematically inFIG. 4A ) in a collapsed shape withinouter shaft 92. A plurality ofcontrol wires 97 have anouter extremity 98 outside ofinner shaft 94 and aninner extremity 100 extending through one ormore lumens 102 anddistal ports 103 ininner shaft 94. Bothouter portion 98 andinner portion 100 extend proximally to the proximal end ofdelivery catheter 90.Outer extremities 98 are threaded through openings in the wall ofstent 96 or are otherwise coupled thereto as described above so as to resist expansion ofstent 96 upon deployment.Control wires 97 thus form a continuous loop from the proximal end ofstent delivery catheter 90, throughstent 96 and back to the proximal end of the catheter. -
FIG. 4B illustrates this embodiment ofdelivery catheter 90 positioned in a vessel V and carrying plurality ofstents 96′.Stents 96′ haveaxial projections 104 at their distal and proximal ends configured to interleave whenstents 96′ are collapsed withinouter shaft 92 and when deployed in vessel V. Whenouter shaft 92 is retracted to expose one ormore stents 96′, the expansion ofstents 96′ can be resisted and controlled by maintaining tension oncontrol wires 97. Tension may be controllably relaxed to allowstents 96′ to expand into contact with lesion L, as shown inFIG. 4B . By controlling the expansion in this way, the axial spacing and rotational positions ofadjacent stents 96′ may be maintained so that gaps and overlaps are minimized and the interleaving ofaxial projections 104 is maintained. Whenstents 96′ are fully expanded, one end of eachcontrol wire 97 may be released at the proximal end ofdelivery catheter 90 while the other end is pulled to retract the control wires fromstents 96′. - In a further embodiment, illustrated schematically in FIGS. 5A-B,
delivery catheter 108 is constructed as described above except thatcontrol wires 110 are releasably coupled to the distal end of aninner shaft 112 or tonose cone 114. In an exemplary embodiment,control wires 110 haveballs 116 at their distal ends configured to be received withinslots 118 on the outer surface of nosecone 114 (FIG. 5A ) or on the proximal face of nosecone 114 (FIG. 5B ; outer shaft not shown for clarity).Slots 118 have anenlarged portion 120 of sufficient size to receiveball 116 and anarrow portion 122 through whichballs 116 may not pass.Inner shaft 112 is axially rotatable relative to controlwires 110. As in the embodiment of FIGS. 4A-B, withballs 116 held withinslots 118, tension may be maintained oncontrol wires 110 to resist expansion ofstent 124.Stent 124 may be allowed to expand by gradually relaxing tension oncontrol wires 110. Oncestent 124 is fully expanded tension oncontrol wires 110 may be fully relaxed andnosecone 114 then rotated by rotatinginner shaft 112, thereby allowingballs 116 to pass throughenlarged portions 120.Control wires 110 may then be withdrawn from the deployedstent 124.Nosecone 114 is then retracted orcontrol wires 110 advanced so as to reinsertballs 116 intoslots 118.Nosecone 114 is then rotated to alignballs 116 withnarrow portions 122, again securing the control wires tonosecone 114.Delivery catheter 108 may then be repositioned to deploy additional stents. - Optionally,
delivery catheter 108 may include a middle shaft orballoon 126 over whichstents 124 are positioned, as shown inFIG. 5A . In this case,inner shaft 112 is slidably and rotatably disposed in an inner lumen though middle shaft orballoon 126. If a balloon is included, it may be used for pre-dilatation of lesions prior to stent deployment, or for further expansion ofstent 124 following deployment. - In the foregoing embodiment,
control wires 110 will be constructed to have sufficient stiffness to resist rotation, twisting or bending asnosecone 114 is rotated to releasecontrol wires 110. Maintaining some tension oncontrol wires 110 asnosecone 114 is rotated may facilitate the release process. In addition,control wires 110 will have sufficient column strength to facilitate reinsertion intoslots 118 following deployment ofstents 124. Thus the size, material and geometry ofcontrol wires 110 will be selected to enable these actions while providing the desired level of control of stent expansion. - In a further embodiment of a stent delivery catheter according to the invention, an
expandable sleeve 130 is slidably positioned withinouter shaft 132 and carriesstents 134 as shown in FIGS. 6A-C.A pusher shaft 136 is slidable withinsleeve 130 and engages theproximal-most stent 134. Aninner shaft 138 extends throughpusher shaft 136 and has anosecone 140 fixed to its distal end.Sleeve 130, or at least a distal extremity thereof, may be a tube constructed of a resilient deformable material such as urethane or other medical grade elastomer, or may be a tubular mesh, cage, grating, or other suitable structure of flexible and resilient polymer or metal such as stainless steel or Nitinol. The elasticity and stiffness ofsleeve 130 are selected to allowstents 134 to expand at the desired rate when deployed fromouter shaft 132 without excessive axial or rotational displacement relative to each other or toouter shaft 132.Sleeve 130 is resiliently biased toward an unexpanded shape so that following stent deployment,sleeve 130 returns to a generally tubular shape.Outer shaft 132 is constructed of a material with sufficient radial strength and stiffness to resist expansion ofstents 134 andsleeve 130, and may include a metallic or polymeric braid, ribs, rings or other structural reinforcement near its distal end for such purpose. - The interior surface of
sleeve 130 optionally may have surface features such as bumps, scales, bristles, ribs, or roughness to enhance friction withstents 134. These features may be configured to have a grain such that they provide more friction against movement in the distal direction than in the proximal direction, or vice versa. Further, such features may be adapted to provide more friction whensleeve 130 is in an unexpanded shape than when it is expanded bystents 134. For example, bristles may be provided that point more in the proximal direction whensleeve 130 is in its unexpanded cylindrical shape, but which point more distally or radially (perpendicular to the surface of sleeve 130) whensleeve 130 is expanded. This allowssleeve 130 to be more easily withdrawn fromstents 134 whenstents 134 are deployed. - In order to deploy
stents 134,delivery catheter 129 is positioned across a vascular lesion so thatnosecone 140 is disposed just distally of the distal end of the lesion.Outer shaft 132 is then retracted to expose the desired number of stents 134 (and the associated length of sleeve 130) which will cover the length of the lesion, as shown inFIG. 6B . Asouter shaft 132 is retracted,stents 134 are allowed to expand into contact with the lesion as shown inFIG. 6C .Sleeve 130 controls the rate of expansion and maintains the positions ofstents 134 so they are deployed precisely at the intended location. Oncestents 134 are fully expanded,sleeve 130 may be retracted from between the stents and the lesion untilsleeve 130 is again disposed inouter shaft 132. Pressure is maintained onpusher shaft 136 during this process so that thestents 134 remaining indelivery catheter 129 are advanced to the distal end ofsleeve 130 andouter shaft 132.Delivery catheter 129 may then be repositioned for deployment of additional stents at other locations. - Referring now to FIGS. 7A-B, in a further embodiment, a
delivery catheter 142 may be constructed largely as described in connection with FIGS. 6A-C, including anouter shaft 144, anexpandable sleeve 146 slidably disposed therein, apusher shaft 148, andinner shaft 150. A plurality ofstents 152 are carried in expandable sleeve 146 (shown inFIG. 7B ). In order to facilitate expansion,expandable sleeve 146 includes a longitudinal slit 154 in at least a distal extremity thereof. Whenouter shaft 144 is retracted relative tosleeve 146,sleeve 146 may be controllably expanded by axially twistingsleeve 146 such that the opposingedges 156 along longitudinal slit 154 pivot away from one another, forming a cone shape (FIG. 7B ). In this way, the expansion ofstents 152 is further controllable after retraction ofouter shaft 144 by controlling the rate of twisting ofsleeve 146. An actuator may be provided at the proximal end ofdelivery catheter 142 to control such twisting. Optionally,sleeve 146 may have a helical thread on its outer surface that mates with a complementary thread on the interior ofouter shaft 144 such thatsleeve 146 is automatically twisted asouter shaft 144 is retracted. As in the embodiment of FIGS. 6A-C, following stent deployment,sleeve 146 is retracted from the space between the deployed stents and the vessel wall and returned withinouter shaft 144.Sleeve 146 may be resiliently biased to return to its unexpanded configuration, or may be manually twisted back to an unexpanded shape by the operator. - In another embodiment, shown in FIGS. 8A-C,
delivery catheter 160 is again constructed much likedelivery catheter 129 of FIGS. 6A-C, including anouter shaft 162, a slidableexpandable sleeve 164 carryingstents 166, apusher shaft 168, and aninner shaft 170. Anosecone 172 is attached to the distal end ofinner shaft 170 and has aconcavity 174 at its proximal end configured to receive the distal end ofsleeve 164. A distal extremity ofsleeve 164 includes a plurality ofaxial slits 176 defining separate deflectablelongitudinal beams 178.Sleeve 164 includes at least two, preferably four, and as many as six, eight, ormore slits 176 to provide a corresponding number oflongitudinal beams 178.Longitudinal beams 178 are resiliently biased into an axial orientation whereinsleeve 164 is generally cylindrical.Longitudinal beams 178 have sufficient stiffness against lateral deflection to resist and control the expansion ofstents 166. - Advantageously, by containing the distal ends of
longitudinal beams 178 inconcavity 174,outer shaft 162 may be retracted to expose the desired number of stents to cover a target lesion without immediate expansion ofstents 166, as shown inFIG. 8B . When the desired number ofstents 166 is exposed,inner shaft 170 may be advanced distally relative tosleeve 164, releasinglongitudinal beams 178 fromconcavity 174. This permitslongitudinal beams 178 to laterally deflect, allowingstents 166 to expand, as shown inFIG. 8C . When full expansion is achieved,longitudinal beams 178 may be retracted from betweenstents 166 and the vessel wall.Longitudinal beams 178 then return to their undeflected axial orientation, allowinginner shaft 170 to be retracted so as to return the distal ends oflongitudinal beams 178 intoconcavity 174.Inner shaft 170 andsleeve 164 may then be retracted intoouter shaft 162 while maintaining pressure onpusher shaft 168, thereby advancingadditional stents 166 toward the distal end ofsleeve 164 for additional deployments. - In some embodiments of the stent delivery catheter of the invention, the stents themselves are configured to provide greater control and precision in stent deployment. For example,
FIGS. 9A-9B illustrates adelivery catheter 180 having a plurality ofstents 182 disposed in anouter shaft 184. Aninner shaft 186 withoptional balloon 188 andnosecone 190 extends throughouter shaft 184 andstents 182 and is axially movable relative thereto. A pusher shaft (not shown) is slidably disposed overinner shaft 186 and engagesstents 182 for purposes of deployingstents 182 fromouter shaft 186 and repositioning the remainingstents 182 withinouter shaft 186, as in earlier embodiments. In this embodiment,stents 182 comprise a plurality ofstruts 191 forming a series ofrings 192 interconnected atjoints 193. Eachring 192 has a series ofclosed cells 194 interconnected circumferentially and having an “I” shape in the unexpanded configuration. - As
outer shaft 184 is retracted to deploy one ormore stents 182, at least adistal ring 192′ is configured to expand into engagement with the vessel wall before the entire length of thestent 182 is deployed from outer shaft 184 (FIG. 9A ). Once in engagement with the lesion L in vessel V,distal ring 192′anchors stent 182 in position as the remainder of the stent is deployed (FIG. 9B ), preventing “watermelon seeding” of the stent from the catheter. The axial length ofstent 182, the length of eachring 192, the number of rings, the stiffness ofstruts 191, and the flexibility ofjoints 193 are all selected to optimize this deployment behavior. Eachstent 182 has at least two, and preferably four ormore rings 192, each ring being about 2-5 mm in length, givingstent 182 an overall length of at least about 8-20 mm. Of course, stents of shorter or longer length are also contemplated within the scope of the invention. Lesions longer than eachstent 182 may be treated by deployingmultiple stents 182 end-to-end. Advantageously, eachstent 182 can be deployed precisely at a desired spacing from a previously-deployedstent 182 because thedistal ring 192′ of eachstent 182 can be first allowed to expand into engagement with the vessel at the target location, anchoring the stent in position as the remainder is deployed. -
Rings 192 are preferably formed from a common piece of material and are integrally interconnected atjoints 193, makingjoints 193 relatively rigid. In this embodiment, the majority of flexibility betweenrings 192 is provided bystruts 191 rather than byjoints 193. Alternatively, joints 193 may comprise welded connections betweenrings 192 which are also fairly rigid. As a further alternative,joints 193 may comprise hinge or spring structures to allow greater deflection betweenadjacent rings 192, as exemplified inFIGS. 10A-10B , described below. - In the embodiment of
FIG. 10A-10B ,stents 200 are constructed similarly tostents 182 ofFIGS. 9A-9B , including a plurality ofinterconnected rings 202 having I-shapedcells 204. However, in this embodiment, some ofrings 202 are interconnected byspring members 206 that may be elongated to increase the distance betweenrings 202 and that are resiliently biased into a shortened configuration to drawrings 202 toward each other. In one embodiment,spring members 206 have a wave-like shape and extend from the tip of anaxial projection 208 on onering 202 to aconcave portion 210 betweenaxial projections 208 on theadjacent ring 202. Of course a variety of spring configurations and connection locations are possible, including zig-zags, coils, spirals, accordian or telescoping structures, and the like. Further, resilient elongatable elastomeric elements may link the adjacent rings 202. In the illustrated embodiment,stent 200 comprises two pairs ofrings 202, with the rings of each pair interconnected byintegral joints 212 as in FIGS. 9A-B and the pairs ofrings 202 being connected to each other byspring members 206.Stents 200 may alternatively include two, three, five, six ormore rings 202, andspring members 206 may interconnect all or only a portion ofrings 202. -
Spring members 206 may be formed of the same or different material as that ofrings 202, depending upon the desired performance characteristics. In addition,spring members 206 may be biodegradable so as to erode and eventually disappear, leaving the adjacent pairs ofrings 202 unconnected. - During deployment, as
outer shaft 184 is retracted to expose astent 200, the distal pair ofrings 202′ first expands into engagement with lesion L in vessel V (FIG. 10A ).Spring members 206 elongate to allowrings 202′ to fully expand without pulling the second pair ofrings 202″ fromouter shaft 184. As retraction ofouter shaft 184 continues, the second pair ofrings 202″ expands and simultaneously is drawn towarddistal ring pair 182′ by contraction of spring members 206 (FIG. 10B ). This results in a predictable and constant axial spacing between the adjacent pairs ofrings 202. In addition,spring members 206 maintain rotational alignment ofrings 202 to maintain the interleaving ofaxial projections 208 without overlap. As in previous embodiments,multiple stents 200 may be deployed sequentially fromdelivery catheter 180 to cover longer lesions. The ability to precisely deploy each stent permits the relative axial spacing and rotational position of such stents to be controlled to avoid excessive space or overlap. - In a further embodiment, shown schematically in
FIGS. 11A-11C , adelivery catheter 216 has anouter shaft 218 carrying a plurality ofstents 220. Aninner shaft 222 extends throughouter shaft 218 to anosecone 224, and apusher shaft 226 is slidably disposed overinner shaft 222. An anchoringballoon 228 is mounted toinner shaft 222 proximal tonosecone 224. Anchoringballoon 228 has an axial length sufficient to frictionally engage the wall of vessel V and remain stable so as to anchordelivery catheter 216 in place as further described below. Preferably, anchoringballoon 228 has a length about equal to the length of one ofstents 220. - In use,
outer shaft 218 is retracted so that afirst stent 220′ is released therefrom and expands into engagement with lesion L (FIG. 11A ). Anchoringballoon 228 is then inflated until it engages the interior ofstent 220′ (FIG. 11B ). This not only stabilizesdelivery catheter 216, but may be used to further expandstent 220′ and/or dilate lesion L to firmly implantstent 220′. While keeping anchoring balloon inflated withinstent 220′,outer shaft 218 is further retracted to release asecond stent 220″, which expands into engagement with lesion L (FIG. 11C ). Advantageously, anchoringballoon 228 stabilizesdelivery catheter 216 and anchors it in position relative tofirst stent 220′ assecond stent 220″ is deployed.Second stent 220″ is thus deployable precisely at the intended spacing and rotational position relative tofirst stent 220′. Anchoringballoon 228 may then be deflated and retracted intoouter shaft 218, with pressure maintained uponpusher shaft 226 to reposition remainingstents 220 at the distal end ofinner shaft 222. -
FIGS. 11D-11F illustrate another embodiment of adelivery catheter 219 in which a plurality of self-expandingstents 221 are slidably disposed over anelongated balloon 223.Balloon 223 preferably has a length as long as the longest lesion that is to be treated with the device, e.g. 50-200 mm. Apusher 225 is slidable relative to balloon 223 and has a tubulardistal portion 227 disposed overballoon 223 which engages theproximal-most stent 221P. Asheath 229 is slidably disposed overpusher 225,stents 221 andballoon 223 and maintainsstents 221 in a radially contracted configuration. In this embodiment, moderate pressure is maintained withinballoon 223 during deployment ofstents 221 so that the balloon expands simultaneously with each stent. As shown inFIG. 11B , assheath 229 is retracted, afirst stent 221A and a distal portion ofballoon 223 are exposed. By maintaining moderate inflation pressure inballoon 223 assheath 220 is retracted the exposed portion ofballoon 223 expands with thefirst stent 221A, inhibiting distal migration of the stent fromdelivery catheter 219. One or moreadditional stents 221 may be deployed by further retraction ofsheath 229, during whichballoon 223 remains expanded withinfirst stent 221 anchoring thedelivery catheter 219 in position (not shown). As each additional stent is exposed fromsheath 229, the pressure inballoon 223 causes it to expand with the stent so as to control its rotational and axial position. Of course,stents 221 may have any of a variety of different configurations, including having open or closed cells, zig-zag or wave-shaped struts, and/or axially interleaving elements as described above. - Optionally,
balloon 223 may have surface features or coatings on its periphery that enhance retention ofstents 221 thereon. Such features may include structures such as scales or protuberances that are activated by pressurization of the balloon so that retention is lessened when the balloon is deflated, but heightened when the balloon is pressurized. Following stent deployment, pressure can optionally be increased inballoon 223 for post-dilation ofstents 221 and the targetlesion L. Balloon 223 is then deflated and retracted withinsheath 229 as distal pressure is maintained againstpusher 225, repositioningstents 221 near the distal end ofballoon 223 withinsheath 229 for deployment at another location, as shown inFIG. 11C . - In a further embodiment, the stents in the delivery catheter of the invention may releasably interconnect with one another and/or with the pusher shaft to enable greater control and precision during deployment. As illustrated in
FIG. 12 ,delivery catheter 230 carries a plurality ofstents 232 having a structure much like that described above in connection withFIGS. 9A-9B . However, in this embodiment, theaxial projections 234 extending distally and proximally fromstents 232 are configured to interconnect withconcavities 236 onadjacent stents 232 until expanded. In one embodiment,axial projections 234 have enlargedheads 246 andconcavities 236 havenecks 248 that retainheads 246 withinconcavities 236 in the unexpanded configuration.Pusher shaft 250 has adistal end 252 havingprojections 254 andconcavities 256 like those ofstents 232, thus being able to interconnect with theproximal-most stent 232′. When astent 232″ expands, the interconnecting structures thereon are configured to separate from the adjacent stent or pusher shaft, thus releasing the deployedstent 232″ fromdelivery catheter 230. In the example shown, asstent 232″ expands, heads 246″ contract in size whilenecks 248″ enlarge, thereby allowingheads 246″ on the expanded stent to be released fromconcavities 236 in the adjacent unexpanded stent, and vice versa. By exerting traction onpusher shaft 250 during the deployment process, the line ofstents 232 is kept from moving distally relative toouter shaft 231, thus preventing the deployedstent 232″ from “watermelon seeding” as it expands. - Various types of interconnecting structures between adjacent stents and between the stents and the pusher shaft are possible within the scope of the invention, including those described in co-pending application Ser. No. 10/738,666, filed Dec. 16, 2003, which is incorporated herein by reference. Such interconnecting structures may also be breakable or frangible to facilitate separation as the stent expands. In addition, a mechanism such as an expandable balloon or cutting device may be disposed at the distal end of
delivery catheter 230 to assist in separatingstents 232 upon deployment. Further, the interconnections between stents may be different than the interconnection between the proximal-most stent and the pusher shaft. For example, the pusher shaft may have hooks, magnets, or other mechanisms suitable for releasably holding and maintaining traction on the proximal end of a stent until it is deployed. - While the above is a complete description of the preferred embodiments of the invention, various alternatives, modifications, improvements and additions are possible without departing from the scope thereof, which is defined by the claims.
Claims (45)
1. A prosthesis delivery catheter comprising:
an outer shaft having a first lumen;
a plurality of self-expanding tubular prostheses carried within the first lumen, the prostheses being adapted to radially expand upon deployment from the first lumen;
a deployment mechanism for deploying a selected number of the prostheses from the first lumen; and
a control member interactive with the prostheses to control expansion of the prostheses when the prostheses are deployed from the first lumen.
2. The prosthesis delivery catheter of claim 1 wherein the control member comprises a plurality of axially-extending wires, the prostheses being coupled to the wires and axially slidable thereon, the wires being radially deflectable to allow controlled expansion of the prostheses.
3. The prosthesis delivery catheter of claim 2 wherein the wires have free distal ends configured to move radially outward as the prostheses expand.
4. The prosthesis delivery catheter of claim 3 wherein the distal ends are retractable into the outer shaft following deployment of the selected number of prostheses.
5. The prosthesis delivery catheter of claim 2 wherein the prostheses have sidewalls with a plurality of openings, the wires being threaded through the openings.
6. The prosthesis delivery catheter of claim 2 wherein the wires form a loop extending around the outside of the prostheses and through the inside of the prostheses.
7. The prosthesis delivery catheter of claim 6 wherein the wires can be withdrawn from around the prostheses following deployment thereof.
8. The prosthesis delivery catheter of claim 7 wherein at least one end of each wire is releasable to allow the wire to be withdrawn following prosthesis deployment.
9. The prosthesis delivery catheter of claim 8 further comprising an inner shaft disposed in the first lumen, the prostheses being slidably disposed around the inner shaft, wherein a distal end of each wire is releasably coupled to the inner shaft.
10. The prosthesis delivery catheter of claim 9 further comprising a nosecone attached to the inner shaft distally of the prostheses, the distal end of each wire being releasably coupled to the nosecone.
11. The prosthesis delivery catheter of claim 9 wherein the inner shaft has an inner lumen and at least one port in communication with the inner lumen, the wires being slidably disposed through the inner lumen and the port.
12. The prosthesis delivery catheter of claim 1 wherein the control member comprises a sleeve disposed around the prostheses, the sleeve being expandable to allow controlled expansion of the prostheses.
13. The prosthesis delivery catheter of claim 12 wherein the sleeve is elastomeric.
14. The prosthesis delivery catheter of claim 12 wherein the sleeve is slidable relative to the outer shaft.
15. The prosthesis delivery catheter of claim 12 wherein the sleeve has at least one longitudinal slit therein, the sleeve expanding by splitting at the longitudinal slit.
16. The prosthesis delivery catheter of claim 15 wherein the sleeve comprises a plurality of longitudinal sections separated by longitudinal slits, the longitudinal sections being deflectable outwardly to allow controlled expansion of the prostheses.
17. The prosthesis delivery catheter of claim 16 further comprising a retainer releasably coupled to the longitudinal sections to selectively prevent radial deflection thereof.
18. The prosthesis delivery catheter of claim 17 further comprising an inner shaft slidably disposed through the first lumen and having a distal end, the retainer being coupled to the distal end.
19. The prosthesis delivery catheter of claim 15 wherein the sleeve expands by forming a cone shape that flares in the distal direction.
20. The prosthesis delivery catheter of claim 19 wherein the sleeve has a pair of opposing edges bordering the longitudinal slit, the cone shape being formed by moving the edges at an angle relative to each other.
21. The prosthesis delivery catheter of claim 1 wherein the deployment mechanisms comprises a pushing element slidably disposed in the first lumen, the pushing element being in engagement with at least one of the prostheses to advance the prostheses distally relative to the outer shaft.
22. The prosthesis delivery catheter of claim 21 wherein the plurality of prostheses are releasably interconnected to each other.
23. The prosthesis delivery catheter of claim 22 wherein the control member comprises an interconnection structure on the pushing element, the interconnection structure being releasably coupled to at least one of the prostheses to resist distal movement of the prostheses relative to the outer shaft.
24. The prosthesis delivery catheter of claim 1 wherein the control member is configured to maintain rotational position of the prostheses relative to each other.
25. A prosthesis delivery catheter for delivering prostheses into a vessel lumen comprising:
an outer shaft having a first lumen;
a plurality of self-expanding tubular prostheses carried within the first lumen, the prostheses being adapted to radially expand upon deployment from the first lumen;
a deployment mechanism for deploying a selected number of the prostheses from the first lumen; and
a anchor member adapted to engage the vessel to limit movement of the outer shaft relative thereto when a prosthesis is being deployed.
26. The prosthesis delivery catheter of claim 25 wherein the anchor member comprises an expandable member mounted on an inner shaft, the inner shaft being slidably disposed in the first lumen.
27. The prosthesis delivery catheter of claim 26 wherein expandable member comprises a balloon.
28. The prosthesis delivery catheter of claim 26 wherein the expandable member is configured to expand within a deployed prosthesis in the vessel lumen.
29. The prosthesis delivery catheter of claim 28 wherein the expandable member is configured to remain expanded within the deployed prosthesis while a second prosthesis is deployed adjacent to the deployed prosthesis.
30. A prosthesis delivery catheter for delivering prostheses into a vessel lumen comprising:
an outer shaft having a first lumen;
a plurality of self-expanding tubular prostheses carried within the first lumen, the prostheses being adapted to radially expand upon deployment from the first lumen, each prosthesis comprising a distal portion and proximal portion, the distal portion being configured to expand into engagement with the vessel while the proximal portion is at least partially disposed in the first lumen; and
a deployment mechanism for deploying a selected number of the prostheses from the first lumen.
31. The prosthesis delivery catheter of claim 30 wherein the distal and proximal portions are interconnected by at least one spring member, the spring member having a retracted shape and an elongated shape and being biased into the retracted shape, wherein deployment of the distal portion into the vessel elongates the spring into the elongated shape.
32. The prosthesis delivery catheter of claim 31 wherein deployment of the proximal portion into the vessel allows the spring to return at least partially to the retracted shape to draw the proximal portion toward the distal portion.
33. The prosthesis delivery catheter of claim 30 wherein the distal portion is configured to engage the vessel prior to deployment of the proximal portion so that the prosthesis remains in a generally constant position relative to the catheter as the proximal portion is deployed.
34. A method of delivering one or more prostheses to a treatment site in a vessel comprising:
positioning a delivery catheter at the treatment site, the delivery catheter carrying a plurality of self-expanding prostheses;
selecting a desired number of the prostheses to deploy;
deploying the desired number of prostheses from the delivery catheter into the vessel, each prosthesis expanding into contact with the vessel upon deployment; and
controlling the axial displacement of each of the selected number of prostheses relative to the delivery catheter during the deployment thereof.
35. The method of claim 34 wherein the axial displacement is controlled by an expandable sleeve disposed around the desired number of prostheses.
36. The method of claim 35 further comprising retracting the sleeve from around the prostheses after the prostheses have been deployed.
37. The method of claim 34 wherein the axial displacement is controlled by a plurality of wires coupled with the desired number of prostheses.
38. The method of claim 37 further comprising retracting the wires from the prostheses after the prostheses have been deployed.
39. The method of claim 37 wherein the wires are threaded through openings in each of the prostheses.
40. The method of claim 34 further comprising controlling the rotational displacement of the selected number of prostheses relative to the delivery catheter during the deployment thereof.
41. The method of claim 34 wherein the axial displacement is controlled by expanding an expandable member in the vessel during deployment of at least a portion of the desired number of prostheses.
42. The method of claim 34 wherein the axial displacement is controlled by expanding a distal portion of a first of the prostheses into engagement with the vessel while a proximal portion of the first of the prostheses remains in the delivery catheter, then expanding the proximal portion of the first of the prostheses into engagement with the vessel.
43. The method of claim 34 wherein the prostheses are releasably interconnected while in the delivery catheter.
44. The method of claim 43 wherein the axial displacement is controlled by connecting at least one of the prostheses to a restraining member in the delivery catheter.
45. The method of claim 43 wherein the selected number of prostheses detach from the prostheses remaining in the delivery catheter upon deployment.
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US10/879,949 US20050288766A1 (en) | 2004-06-28 | 2004-06-28 | Devices and methods for controlling expandable prostheses during deployment |
US10/944,282 US7300456B2 (en) | 2004-06-28 | 2004-09-17 | Custom-length self-expanding stent delivery systems with stent bumpers |
US10/957,079 US20050288764A1 (en) | 2004-06-28 | 2004-09-30 | Devices and methods for controlling expandable prosthesis during develoyment |
AU2005260787A AU2005260787A1 (en) | 2004-06-28 | 2005-06-23 | Devices and methods for controlling expandable prostheses during deployment |
EP05778125.4A EP1761206B1 (en) | 2004-06-28 | 2005-06-23 | Devices and methods for controlling expandable prostheses during deployment |
JP2007518394A JP4891901B2 (en) | 2004-06-28 | 2005-06-23 | Device and method for controlling an expandable prosthesis during deployment |
PCT/US2005/024931 WO2006005082A2 (en) | 2004-06-28 | 2005-06-23 | Devices and methods for controlling expandable prostheses during deployment |
CA002568733A CA2568733A1 (en) | 2004-06-28 | 2005-06-23 | Devices and methods for controlling expandable prostheses during deployment |
US11/752,448 US8317859B2 (en) | 2004-06-28 | 2007-05-23 | Devices and methods for controlling expandable prostheses during deployment |
US11/945,142 US20080077229A1 (en) | 2004-06-28 | 2007-11-26 | Custom-length self-expanding stent delivery systems with stent bumpers |
US12/471,064 US8986362B2 (en) | 2004-06-28 | 2009-05-22 | Devices and methods for controlling expandable prostheses during deployment |
US13/684,006 US9700448B2 (en) | 2004-06-28 | 2012-11-21 | Devices and methods for controlling expandable prostheses during deployment |
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US10/957,079 Continuation-In-Part US20050288764A1 (en) | 2004-06-28 | 2004-09-30 | Devices and methods for controlling expandable prosthesis during develoyment |
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US10/957,079 Abandoned US20050288764A1 (en) | 2004-06-28 | 2004-09-30 | Devices and methods for controlling expandable prosthesis during develoyment |
US11/945,142 Abandoned US20080077229A1 (en) | 2004-06-28 | 2007-11-26 | Custom-length self-expanding stent delivery systems with stent bumpers |
US12/471,064 Active US8986362B2 (en) | 2004-06-28 | 2009-05-22 | Devices and methods for controlling expandable prostheses during deployment |
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US10/957,079 Abandoned US20050288764A1 (en) | 2004-06-28 | 2004-09-30 | Devices and methods for controlling expandable prosthesis during develoyment |
US11/945,142 Abandoned US20080077229A1 (en) | 2004-06-28 | 2007-11-26 | Custom-length self-expanding stent delivery systems with stent bumpers |
US12/471,064 Active US8986362B2 (en) | 2004-06-28 | 2009-05-22 | Devices and methods for controlling expandable prostheses during deployment |
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US8986362B2 (en) | 2015-03-24 |
US7300456B2 (en) | 2007-11-27 |
US20080077229A1 (en) | 2008-03-27 |
US20090234428A1 (en) | 2009-09-17 |
US20050288763A1 (en) | 2005-12-29 |
US20050288764A1 (en) | 2005-12-29 |
JP2008504078A (en) | 2008-02-14 |
JP4891901B2 (en) | 2012-03-07 |
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