US20050177145A1 - Method and system for photoselective vaporization for gynecological treatments - Google Patents

Method and system for photoselective vaporization for gynecological treatments Download PDF

Info

Publication number
US20050177145A1
US20050177145A1 US11/099,040 US9904005A US2005177145A1 US 20050177145 A1 US20050177145 A1 US 20050177145A1 US 9904005 A US9904005 A US 9904005A US 2005177145 A1 US2005177145 A1 US 2005177145A1
Authority
US
United States
Prior art keywords
laser
tissue
optical fiber
treatment area
radiation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
US11/099,040
Inventor
Kester Nahen
Steven Murray
Scott Davenport
Tony Coleman
Ken Arnold
Henry Garlich
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Laserscope Inc
Original Assignee
Laserscope Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Laserscope Inc filed Critical Laserscope Inc
Priority to US11/099,040 priority Critical patent/US20050177145A1/en
Publication of US20050177145A1 publication Critical patent/US20050177145A1/en
Assigned to CIT HEALTHCARE LLC reassignment CIT HEALTHCARE LLC SECURITY AGREEMENT Assignors: LASERSCOPE
Assigned to LASERSCOPE reassignment LASERSCOPE RELEASE BY SECURED PARTY (SEE DOCUMENT FOR DETAILS). Assignors: CIT HEALTHCARE LLC
Assigned to MORGAN STANLEY SENIOR FUNDING, INC., AS ADMINISTRATIVE AGENT reassignment MORGAN STANLEY SENIOR FUNDING, INC., AS ADMINISTRATIVE AGENT SECURITY AGREEMENT Assignors: LASERSCOPE
Assigned to AMS RESEARCH CORPORATION reassignment AMS RESEARCH CORPORATION RELEASE OF PATENT SECURITY INTEREST Assignors: MORGAN STANLEY SENIOR FUNDING, INC., AS ADMINISTRATIVE AGENT
Assigned to LASERSCOPE reassignment LASERSCOPE RELEASE OF PATENT SECURITY INTEREST Assignors: MORGAN STANLEY SENIOR FUNDING, INC., AS ADMINISTRATIVE AGENT
Abandoned legal-status Critical Current

Links

Images

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B18/18Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves
    • A61B18/20Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser
    • A61B18/22Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser the beam being directed along or through a flexible conduit, e.g. an optical fibre; Couplings or hand-pieces therefor
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/42Gynaecological or obstetrical instruments or methods
    • A61B2017/4216Operations on uterus, e.g. endometrium
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B2018/00571Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body for achieving a particular surgical effect
    • A61B2018/00625Vaporization
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B18/18Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves
    • A61B18/20Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser
    • A61B18/22Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser the beam being directed along or through a flexible conduit, e.g. an optical fibre; Couplings or hand-pieces therefor
    • A61B2018/2255Optical elements at the distal end of probe tips
    • A61B2018/2272Optical elements at the distal end of probe tips with reflective or refractive surfaces for deflecting the beam

Definitions

  • the present invention relates generally to laser treatment of tissue, and more particularly to photoselective vaporization of tissue, including uterine tissue, as applied to the treatment of gynecological conditions.
  • a commonly employed procedure for removal of tissue in the treatment of gynecological conditions involves the use of a hysteroscope and a small wire loop energized by radio frequency energy to cut tissue.
  • Nd:YAG lasers delivering output with a wavelength of 1064 nm have been used for the treatment of gynecological conditions such as the ablation of the endometrium.
  • 1064 nm light is hemostatic at high power levels, its low absorption in blood and uterine tissue leads to inefficient ablation and a large residual layer of thermally denatured tissue several millimeters thick.
  • High power densities are required for rapid and efficient vaporization of tissue.
  • the difficulty of achieving higher average output power densities is that when high input powers are supplied to the laser element from an excitation source such as an arclamp a large amount of heat is generated in the lasing element. This heat induces various deleterious effects in the lasing element.
  • the temperature difference between the coolant and the hot lasing element generates a thermally induced graded index lens that decreases the beam quality of the laser and causes the laser to operate with more transverse optical modes than it would otherwise.
  • the M 2 parameter is a well established convention for defining the beam quality of a laser and is discussed in pages 480-482 of Orazio Svelto and David C. Hanna, Principles of Lasers , Plenum Press, New York, 1998, which is incorporated herein by reference.
  • the beam quality measures the degree to which the intensity distribution is Guassian.
  • the quantity M 2 is sometimes called inverse beam quality rather than beam quality but in this application it will be referred to as beam quality.
  • the formula usually used for calculating the angular divergence, ⁇ , of a beam of light of wavelength ⁇ is strictly valid only for a beam having a Guassian intensity distribution.
  • a TEM00 laser beam has a high beam quality with an M 2 of 1, whereas by comparison, high power surgical lasers operate with M 2 values greater than 100.
  • high power lasers typically have an M 2 >144.
  • M 2 the larger number of modes makes M 2 larger and makes it difficult to focus the light into small, low numerical aperture fibers and reduces the ability to project high power density light onto tissue.
  • the vaporization efficiency of CW arclamp pumped 532 nm lasers is significantly reduced.
  • Surgical procedures within the uterus have unique risks. For example, precision surgery is of high importance for patients who want to maintain their fertility. Any surgery in the uterus must avoid weakening of the wall of the uterus, which could lead to complications during pregnancy. Also, the physiological diversity of the uterus increases the difficulty of intrauterine operations. The cornual areas of the uterus represent a vulnerable portion of the uterus. In case of a myoma in the cornu, the uterine wall is further thinned by the myoma, which increases the risk of intraoperative perforation of the uterine wall. Even if perforation does not occur, the presence of a thin uterine wall could predispose the patient to bowel injury. As stated by Indman, J. Reproduct. Med. 1991, lack of precise knowledge of the minimum thickness of the uterine wall may be the limiting factor in determining the safety of use of the 1064 nm Nd:YAG laser for endometrial ablation.
  • Photoselective vaporization of tissue is based upon applying a high intensity radiation to tissue using a radiation that is highly absorptive in the tissue, while being absorbed only to a negligible degree by water or other irrigant during the operation, at power densities such that the majority of the energy is converted to vaporization of the tissue without significant residual coagulation of adjacent tissue.
  • the present invention provides a method for treating gynecologic conditions, including conditions involving uterine tissue, such as intramural and intracavitery uterine myomas, leiomyoma uteri, rhabdomyoma, endometriosis, endometrial hyperplasia, endometrial cysts, endometrial polyps, menorrhagia, uterine septa, intrauterine adhesions, or cervical intraepithelial neoplasia.
  • Other gynecological conditions involving the female reproductive organs such as the fallopian tubes, the ovaries, and the vagina, are also treatable according to the present invention.
  • Treatment according to the embodiments of present invention is executed by vaporizing, incising, or coagulating tissue, such as uterine tissue, using a laser that generates light with an average power greater than 40 watts and a wavelength between 300 and 700 nm where the output beam of the laser is delivered to the target tissue through an optical waveguide, such as an optical fiber that emits light in forward direction (end-firing) or in a laterally directed manner (side-firing) where laterally means at an angle of 10°-170° with respect to the fiber axis, and where the waveguide is guided into the vagina or the uterine cavity using a hysteroscope.
  • the hysteroscope is equipped with a rigid tip.
  • the hysteroscope is equipped with a flexible tip, which can be manipulated by the surgeon, allowing greater control over the procedure, and access to more regions of the target tissue.
  • the wavelength of the delivered radiation is between 1100 and 1800 nm, or in other bands that are efficiently absorbed by the target tissue.
  • Yet other embodiments employ a laser system, that generates light of two wavelengths, with for example two lasers arranged to provide light to a beam delivery system, with the light of the first wavelength having an average power greater than 40 watts, and in some embodiments more than 60 Watts, and a wavelength between 300 and 700 nm, such as a wavelength of 532 nm, and the light of the second wavelength having a wavelength of 1064 nm.
  • delivered light is between 1100 and 1800 nm.
  • a method for treating gynecological conditions comprises the steps of providing a solid-state laser having a laser element positioned to receive pump radiation from an excitation source; in some cases modulating the source to cause the laser to emit pulsed laser light; and delivering the laser light to targeted tissue.
  • Various solid-state lasers may be used for this purpose, including (without limitation), a Q-switched laser using a frequency doubling crystal such as potassium-titanyl-phosphate (KTP), pumped using a diode array, an arc lamp or a flash lamp.
  • KTP potassium-titanyl-phosphate
  • a “macro-pulse” duration of the laser light is preferably in the range of 0.1 to 500 milliseconds, induced by for example modulating the pump energy with the desired macro-pulse length.
  • the wavelength of the laser light is preferably between 200 and 1000 nm, and more preferably between about 300 and 700 nm.
  • the laser light is preferably delivered to the targeted tissue through an optical fiber terminating at or near a distal end in a side-firing or end-firing probe.
  • Operation of the solid-state laser in a “macro-pulsed” mode is more efficient in vaporizing tissue than a CW laser of the same average power. This is in part because the heat generated in a superficial tissue layer, which depth is defined by the optical penetration depth of the laser beam, doesn't have time to significantly diffuse into deeper tissue layers during each macro pulse. The heat stays confined in the superficial tissue layer and leads to a rapid heating of the tissue to the boiling point of water. The thermal energy generated within a tissue volume has to exceed the vaporization enthalpy of water to fully vaporize the tissue. For a laser operated in a macro-pulsed mode this condition is met for a larger tissue volume than for a laser operated in a continuous mode.
  • the macro-pulsed laser is also more efficient and has higher beam quality, with M2 values typically less than 144, than a continuous wave laser with same average output power.
  • the higher beam quality allows for higher irradiances on the tissue and thus a more rapid tissue vaporization.
  • a method for treating uterine tissue comprises the steps of providing a solid-state laser having a laser element positioned to receive pump radiation from a pump radiation source; modulating the pump radiation source to cause the laser element to emit laser light having a pulse duration of between 0.1 milliseconds and 500 milliseconds and an average output power exceeding 20 watts; and delivering the laser light to targeted tissue.
  • a method for treating gynecological conditions comprises the steps of providing a solid-state laser having a laser element positioned to receive pump radiation from a pump radiation source; Q-switching the laser to generate a quasi-continuous wave (CW) beam having an average output power exceeding 60 watts; and, delivering the beam to targeted tissue.
  • CW quasi-continuous wave
  • a method for treating gynecological conditions comprises the steps of providing a solid-state laser having a laser element positioned to receive pump radiation from a pump radiation source such as a laser diode; Q-switching the laser to generate a quasi-continuous wave (CW) beam having an average output power exceeding 20 watts with an M 2 less than 144; and delivering the beam to uterine tissue.
  • a pump radiation source such as a laser diode
  • one embodiment of the invention provides a method for photoselective vaporization of uterine tissue, including for example the endometrium and myomas in the uterine wall.
  • the method includes delivering laser radiation to the treatment area on the tissue, via an optical fiber for example, wherein the laser radiation has a wavelength and irradiance in the treatment area on the surface of the tissue sufficient because vaporization of a substantially greater volume of tissue than a volume of residual coagulated tissue caused by the laser radiation.
  • the laser radiation is generated using a neodymium doped solid-state laser, including optics producing a second or higher harmonic output with greater than 60 watts average output power, and for example 80 watts average output power, or more.
  • the laser radiation is coupled into an optical fiber adapted to direct laser radiation from the fiber to the treatment area on the surface of the tissue.
  • the fiber optic is inserted via hysteroscope, including lumens for delivering irrigants to the treatment area, and for direct visualization during the treatment.
  • a flexible tip hysteroscope is used in embodiments of the present invention.
  • the delivered laser radiation has a wavelength in a range of about 300 nm to about 700 nm, and has an average irradiance in the treatment area greater than about 10 kilowatts/cm 2 , in a spot size of at least 0.05 mm 2 . More preferably, the irradiance is greater than about 20 kilowatts/cm 2 , and even more preferably greater than about 30 kilowatts/cm 2 .
  • the spot size in preferred systems is for example less than about 0.8 mm 2 .
  • the second harmonic output of the neodymium dope solid-state laser is applied using an optical fiber with a flat tip for emitting radiation from the end, or with a side-firing tip.
  • a side-firing tip which causes a diverging beam to be directed out of the optical fiber
  • the time is placed close to the tissue, within about 1 mm from the side of the side-firing tip to contacting the side of the tip. Close placement increases the irradiance delivered to the treatment area so that higher irradiance is available with solid-state lasers generating a 60 to 80 watts average output power.
  • the efficiency of the vaporization and the reduction of injury to residual tissue are sufficient that the procedure may be carried out while applying less anesthesia during the delivery of laser energy, and throughout the procedure, than during other procedures.
  • Anesthesia options for a procedure according to the present invention include, but are not limited to, paracervical block, and general or regional anesthesia techniques.
  • embodiments of the invention include the delivery of the laser energy using a Q-switched, solid-state laser which produces micro-pulses in combination with applying pump power to the laser medium in a sequence a pulses so that output radiation is produced in macro-pulses having a peak power of greater than 200 watts, and more preferably about 240 watts or greater.
  • the peak irradiance in the treatment area during the pulses is thereby substantially increased, and preferably greater than 50 kilowatts/cm 2 , and as much as 90 kilowatts/cm 2 in some embodiments of the invention.
  • FIG. 1 depicts a laser system for implementing the tissue ablation methods of the invention
  • FIG. 2 depicts a side-firing probe for use with the system of FIG. 1 ;
  • FIG. 3 depicts an exemplary output waveform of the FIG. 1 laser when the laser is operated in a macro-pulsed mode
  • FIG. 4 depicts an exemplary output waveform of the FIG. 1 laser when the laser is operated in a quasi-CW mode.
  • FIG. 5 is a block diagram of a laser system adaptable for use according to the present invention.
  • FIG. 6 is a block diagram of an alternative laser system adaptable for use according to the present invention.
  • FIG. 7 is a diagram of a flexible tip hysteroscope, adaptable for use according to the present invention.
  • FIG. 8 illustrates absorption depth in tissue for 532 nm light.
  • FIG. 9 illustrates absorption depth in tissue for 1064 nm light.
  • FIG. 10 is a diagram of a beam path from an end view of a side firing tip, according to one embodiment of the present invention.
  • FIG. 11 is a diagram of a beam path from a side view of the side firing tip of FIG. 10 , according to one embodiment of the present invention.
  • FIG. 12 is a heuristic diagram illustrating operation of the present invention.
  • FIG. 13 illustrates representative gynecological conditions treatable according to the present invention.
  • FIG. 14 illustrates application of a side-firing probe on a hysteroscope for ablation of tissue in treatment of a protruding, intracavitery uterine myoma within the right uterine cornu.
  • FIG. 15 illustrates application of an end-firing probe on a flexible tip hysteroscope for ablation of tissue in treatment of a protruding, intracavitery uterine myoma.
  • FIG. 1 is a block diagram depicting an exemplary laser system 100 which may be employed for implementing the present invention.
  • Laser system 100 includes a solid-state laser 102 , which is used to generate laser light for delivery through optical fiber 106 to target tissue 104 .
  • laser 102 is capable of being operated in a “macro-pulsed” mode, wherein the laser light is emitted as macro-pulses having relatively long pulse durations.
  • Laser 102 more specifically comprises a laser element assembly 110 , pump source 112 , and frequency doubling crystal 122 .
  • laser element 110 outputs 1064 nm light which is focused into frequency doubling crystal 122 to create 532 nm light.
  • laser element assembly 110 may be neodymium doped YAG (Nd:YAG) crystal, which emits light having a wavelength of 1064 nm (infrared light) when excited by pump source 112 .
  • Laser element 110 may alternatively be fabricated from any suitable material wherein transition and lanthanide metal ions are disposed within a crystalline host (such as YAG, Lithium Yttrium Fluoride, Sapphire, Alexandrite, Spinel, Yttrium Orthoaluminate, Potassium Gadolinium Tungstate, Yttrium Orthovandate, or Lanthanum Scandium Borate).
  • a crystalline host such as YAG, Lithium Yttrium Fluoride, Sapphire, Alexandrite, Spinel, Yttrium Orthoaluminate, Potassium Gadolinium Tungstate, Yttrium Orthovandate, or Lanthanum Scandium Borate.
  • Laser element 110 is positioned proximal to pump source 112 and may be arranged in parallel relation therewith, although other geometries and configurations may be employed.
  • Pump source 112 may be any device or apparatus operable to excite laser element assembly 110 .
  • Non-limiting examples of devices which may be used as pump source 112 include: arc lamps, flashlamps, and laser diodes.
  • a Q-switch 114 disposed within laser 102 may be operated in a repetitive mode to cause a train of micro-pulses to be generated by laser 102 .
  • the micro-pulses are less than 1 microsecond in duration separated by about 40 microseconds, creating a quasi-continuous wave train.
  • Q-switch 114 is preferably of the acousto-optic type, but may alternatively comprise a mechanical device such as a rotating prism or aperture, an electro-optical device, or a saturable absorber.
  • Control system 116 for controlling and operating laser 102 .
  • Control system 116 will typically include a control processor which receives input from user controls (including but not limited to a beam on/off control, a beam power control, and a pulse duration control) and processes the input to accordingly generate output signals for adjusting characteristics of the output beam to match the user inputted values or conditions.
  • control system 116 applies an output signal to a power supply (not shown) driving pump source 112 which modulates the energy supplied thereto, in turn controlling the pulse duration of the output beam.
  • FIG. 1 shows a frequency doubled laser with an intracavity frequency doubling element, it is only by way of example.
  • the infrared light can be internally or externally frequency doubled using non-linear crystals such as KTP, Lithium Triborate (LBO), or Beta Barium Borate (BBO) to produce second harmonic 532 nm green light, and higher harmonics.
  • non-linear crystals such as KTP, Lithium Triborate (LBO), or Beta Barium Borate (BBO) to produce second harmonic 532 nm green light, and higher harmonics.
  • the frequency doubled, 532 nm wavelength and the shorter wavelength higher harmonic beams are better absorbed by the tissue, and promote more efficient tissue ablation.
  • the resonant cavity control system is that described in U.S. Pat. No. 5,151,909, which is incorporated by reference as if fully set forth herein.
  • Laser 102 further includes an output port couplable to optical fiber 106 .
  • Output port 118 directs the light generated by laser 102 into optical fiber 106 for delivery to tissue 104 .
  • Mirrors 124 , 126 , 128 , and 130 direct light from the lasing element 110 to the frequency doubling crystal 122 , in addition to forming the resonant cavity of the laser.
  • Mirrors 124 , 126 , 128 , and 130 are configured for focusing the light to form an image just in front of the frequency doubling crystal 122 on the side closer to mirror 130 , and to compensate for thermal lensing in the lasing element.
  • mirrors 124 , 126 , 128 , and 130 are illustrated as flat and parallel to the walls of the laser, typically the focusing is achieved by curving and/or angling the mirrors. Alternatively transmissive optical elements could be used to focus the light and compensate for the thermal imaging.
  • Mirrors 124 , 128 and 130 reflect both the wavelength of light produced by the lasing element (e.g. 1064 nm) and the wavelength of the frequency doubled light (e.g. 532 nm).
  • Mirror 126 only reflects the light originating from the lasing element 110 (e.g. 1064 nm) but is transparent to the frequency doubled light (e.g. 532 nm), forming an output window.
  • Higher harmonic outputs may also be generated from the 1064 nm line, or other line amplified in the laser, including third and fourth harmonics, for shorter wavelengths.
  • Other laser systems may be used, including but not limited to Sapphire lasers, diode lasers, and dye lasers, which are adapted to provide the output power and wavelengths described herein, including wavelengths in the ranges from 200 nm to 1000 nm and from 1100 nm to 1800 nm, for example.
  • optical fiber 106 preferably terminates in a tip 140 having optical elements, or otherwise adapted, for shaping and/or orienting the beam emitted by optical fiber 106 so as to optimize the tissue ablation process.
  • FIG. 2 depicts a side-firing probe tip 200 , which may be used as tip 140 ( FIG. 1 ).
  • the tip 140 is treated to deflect light sideways.
  • Some examples of methods for deflecting the light sideways are to include a light scattering material in the tip 140 and/or to place a reflective element in the tip 140 .
  • the reflective element could be angled at 45°, for example; to deflect the light at 90° with respect to the axis of the fiber 106 .
  • Side-firing probe tip 200 includes an optically transparent sleeve 202 having a transparent window 204 (which may be constructed as a cutout in the wall of sleeve 202 through which the beam is emitted in a direction transverse to the optical axis of fiber 106 .)
  • An acceptable range of angles in which to deflect the light beam is between about 40 to 120 degrees with respect to the axis of the fiber.
  • the preferred embodiments use an angle of either 70 or 100.
  • the angle of 80° is preferred from the standpoint of the ease in manufacturing the tip 200 and the angle of 90° is preferred from the standpoint of the ease in aiming the side firing light.
  • optical fiber 106 is held within an endoscope such as a hysteroscope or similar instrument that allows the clinician to precisely position the distal end of the optical fiber adjacent to the targeted tissue.
  • the endoscope also has channels for supplying and removing an irrigant solution to and from the tissue.
  • light and image guides are also included for illuminating and imaging the tissue so that the clinician may direct the laser light and assess the progress and efficacy of the ablation procedure.
  • Physiologic saline solution typically containing 0.9% sodium chloride, is used as the irrigant in gynecological procedures according to the present invention.
  • FIG. 3 illustrates an exemplary output waveform applied to tissue 104 when laser 102 is operated in the macro-pulsed mode.
  • Each macro-pulse 302 is defined by a train of Q-switched micro-pulses 304 . While a relatively small number of micro-pulses 302 are depicted for purposes of clarity, an actual macro-pulse may comprise hundreds or thousands of component micro-pulses 304 . In the preferred embodiment there are between 2 and 12,200 micro-pulses per macro-pulse.
  • An arc lamp for example, when used as the pump source 112 , is kept at a low power level between pulses that are preferably just enough to maintain the arc. These low pump powers are below the lasing threshold of the laser; as a consequence, there is no laser output between macro-pulses.
  • the pulse duration or width D ( FIG. 3 ) of the output beam is governed by the modulation of pump source 112 , and more specifically by the period during which the pump source 112 is maintained in an “on” or high-power condition.
  • laser 102 will be capable of delivering pulses 302 having pulse durations D in the range of 1 to 20 milliseconds (2 to 490 micro-pulses) or 1 to 50 milliseconds (2 to 1,220 micro-pulses) and average output powers preferably exceeding 60 watts and preferably up to 100 or 200 watts.
  • the ratio of D to the period of the macro-pulses defines the duty cycle, which is typically between 10 and 50%.
  • a laser system 100 of the foregoing description is employed to treat gynecological conditions by ablating targeted tissue 104 .
  • the clinician may utilize an endoscope or similar instrument to guide the distal end and tip 140 of optical fiber 106 into alignment with the targeted tissue 104 .
  • Laser system 100 is then operated in the macro-pulsed mode so that laser 102 generates laser light having the pulsed waveform depicted in FIG. 3 and delivers it through optical fiber 106 to tissue 104 .
  • Prior art techniques for treatment of gynecological conditions by laser ablation (such as the technique described by Indman. in “High-Power Nd:YAG Laser Ablation of the Endometrium,” Journal of Reproductive Medicine , Vol. 36, No. 7, July 1991)) utilized an Nd:YAG laser to irradiate the uterine tissue. Although such lasers do produce moderately high average powers, they have a large number of transverse modes and as such, produce highly divergent light when focused into small fiberoptics. Further, the 1064 nm wavelength is less efficiently absorbed in the target tissue, that the wavelengths desirable according to the present invention. These characteristics of prior art 1064 nm systems lead to less than optimal power densities when the laser light is directed at tissue.
  • ablation rates are relatively slow, significantly lengthening procedure times. Further, undesirable thermal damage to deeper tissue layers may occur.
  • a macro-pulsed beam such as that generated by laser 102 , helps to accelerate ablation rates and reducing procedure time.
  • the macropulsing can also increase efficiency because the threshold voltage required for lasing while macropulsing (the operating threshold) is lower than the initial threshold voltage for lasing (cold threshold).
  • Macropulsing is also more efficient for producing green light because the conversion of infrared light to frequency doubled light increases as the square of the infrared light intensity.
  • the higher peak powers of the macro-pulsed infrared light leads to higher second harmonic conversion efficiency.
  • A is an experimentally determined positive constant.
  • This equation relates the peak input power to the peak output power.
  • decreasing the duty cycle from 100% to 50% (i.e. reducing k from 1 to 0.5) while simultaneously doubling the peak input power Pi results in no change to the average input power ⁇ Pi> and a doubling of the average output power ⁇ Po>.
  • Pulse modulating or macropulsing using Q-switching for example, enables reaching higher average output powers with less thermal lensing due to the lower input power.
  • the frequency doubling crystal has nonlinearly increasing output power as a function of the input power.
  • the second derivative of the output power with respect to the input power may be positive, in which case the rate of increase of the output power increases with increasing input power.
  • the functional dependence of the instantaneous or peak output power, Po, on the instantaneous or peak input power, Pi is such that d 2 ( Po )/ d ( Pi ) 2 >0.
  • Pump source modulation of the laser can produce high peak power macro-pulses and affect the efficiency of the average power output. Macro-pulse in excess of a steady state power can substantially improve the initiation of the vaporization of tissue. The higher peak power of the macro-pulse rapidly may initiate charring which in turn serves as an additional chromophore for the incident energy and enhances the vaporization rate. A 30% macro-pulse duty cycle is sufficient to increase the average power output of an arc lamp pumped laser to greater than 80 watts. Additionally the pump modulation generates macro-pulse with pulse powers greater than 240 watts.
  • tissue 104 may be efficiently and rapidly ablated when laser 102 is operated at an output power of 80 to 100 watts, a pulse duration of 1-50 milliseconds, and a wavelength of 532 nm.
  • laser system 100 may be utilized to ablate other types of tissue 104 involved in gynecological conditions.
  • the clinician may utilize an endoscope or similar instrument to guide the distal end and tip 140 of optical fiber 106 into alignment with the tissue 104 .
  • Laser system 100 is then operated in the macro-pulsed mode so that laser light having the pulsed waveform depicted in FIG. 3 is generated by laser 102 and delivered through optical fiber 106 to tissue 104 .
  • laser system 100 is adjusted to emit a beam having a pulse duration between 0.1 and 500 milliseconds, and an output power of at least 20 watts.
  • the output beam of laser 102 is turned off.
  • treatment of gynecological conditions is effected by operating laser 102 in a quasi-CW mode at an output power greater than 60 watts.
  • the increased denaturization of the tissue is dramatic with increases in power, suggesting a threshold effect.
  • laser 102 generates a continuous train of Q-switched micro-pulses 400 when operated in quasi-CW mode.
  • the laser light is then delivered via optical fiber 106 to targeted tissue 104 .
  • Operation in a quasi-CW mode at powers above 60 watts facilitates formation of char and consequent rapid ablation rates, whereas operation in a quasi-CW mode at powers below 60 watts forms char more slowly and causes more thermal damage to underling tissue.
  • a fourth embodiment of this invention is to produce a high power, high beam quality laser that can project high power density laser light onto tissue. To do this the number of transverse optical modes supported by the resonator needs to be kept as low as possible.
  • Small M 2 and high average powers can be achieved by reducing the degree of thermal lensing in the laser element.
  • Using laser diodes as the excitation source is one effective way of greatly reducing both the size of the lasing element and the thermal gradient responsible for creating the thermal lens. The reason for this is that while 2-10% of the light produced from a flashlamp or arc lamp is converted into useful laser light 30-60% of the light emitted from laser diodes can be converted to laser light. Since the energy that is not converted to laser light is converted into heat, laser diodes deposit significantly less heat in the lasing element and as a consequence create a less powerful thermal lens. In this manner laser diodes can be used to pump crystalline laser elements or fiber lasers to produce high beam quality lasers.
  • Slab and waveguide lasers that can be pumped by laser diodes, arc lamps, or flashlamps are another method of creating low M 2 lasers. This is because the thermal gradient produced in slab lasers is linear across the thin dimension of the slab and not radially dependent in contrast to a typical cylindrical lasing element. The linear thermal gradient does not produce a thermal lens resulting in low M 2 values.
  • some embodiments of this invention are capable producing laser light that upon exiting a flat end of a fiber having a diameter of 600 ⁇ m has a divergence of 15.3° or lower; 15° or lower; 10° or lower; or 5° or lower, and the power density can be 13,400 watts per cm 2 , or greater.
  • FIG. 5 shows a block diagram of a preferred laser system according to the present invention.
  • a laser resonator is defined by end mirror 10 , turning mirrors 12 and 14 , and end mirror 16 . All of these mirrors are high reflecting (greater than 99.8%) at the 1064 nm line.
  • An optical path 24 is defined by these mirrors.
  • a gain medium 18 comprising a Nd:YAG rod is mounted along the optical path within a pump housing 29 .
  • a laser diode array 28 D is also mounted within the housing and supplies pump power to the gain medium in response to current generated in power supply 30 .
  • Representative laser diodes include laser diodes providing output in the range of 805 to 820 nm in wavelength with an input power to the array of pumping diodes in the range of 300 to 500 Watts.
  • the laser diodes used for pump energy are operated in a modulated macro-pulse mode, or in a continuous mode, as suits a particular implementation.
  • a Q-switch 20 between the lamp housing 29 and the turning mirror 12 .
  • a non-linear crystal 22 is mounted between the turning mirror 14 and the back mirror 16 .
  • This non-linear crystal is preferably a KTP crystal aligned for frequency doubling to generate a 532 nm beam.
  • Mirrors 16 and 14 are highly reflective at 532 nm, while mirror 12 is transmissive and operates as an output coupler for the 532 nm beam.
  • the laser resonator is designed for resonating at a first frequency, i.e., 1064 nm along the Z-shaped optical path 24 .
  • a second frequency derived from the 1064 nm beam is generated in the KTP crystal 22 . This beam travels along the path 26 a and is extracted from the resonator to supply an output beam along path 26 b.
  • the output beam along path 26 b passes through a controllable attenuator 36 , a beam splitter 38 , which supplies a portion of the output beam to a surgical detector 40 , and a component group 42 as described in more detail below.
  • the attenuator, detector, and component group are all coupled to a data processing system 34 , across lines 34 j , 34 k , and 34 p.
  • the Q-switch 20 is controlled by Q-switch driver 21 , which is, in turn, coupled to data processor 34 across line 34 i .
  • the Q-switch is an acoustic-optic Q-switch.
  • the power supply 30 generates an electrical power signal for controlling the diode array 28 D.
  • This power signal is controlled by the data processor 34 across line 34 h and by drive circuitry 32 across line 32 a .
  • Drive circuitry 32 a is controlled by the data processor across lines 34 a through 34 g .
  • a sensor 57 is coupled with the data processor to sense an environmental condition, such as temperature or humidity, that affects operation of the laser system.
  • a modem 56 is connected to the data processor 34 , providing an interface for remote access to memory in the data processor.
  • a control panel 35 by which a user can supply input signals and parameters, is provided. This control panel 35 is connected to the data processor 34 across line 34 n.
  • the non-linear crystal may be mounted outside the resonant cavity of the resonator. Also, it may be used for extracting outputs other than the second harmonic, such as sum-of-frequency derivation or the like.
  • the wavelength used according to the present invention for gynecological conditions treatment should be strongly absorbed in the tissue to help initiate and maintain tissue vaporization without creating deep tissue heating.
  • the wavelength also must be minimally absorbed by the irrigant used during the procedure, typically physiologic saline solution.
  • the 532 nm light produced by the system of FIG. 5 is both strongly absorbed in oxyhemoglobin and weakly absorbed in physiologic saline solution.
  • Oxyhemoglobin is readily present in uterine tissue and serves as an efficient chromophore for 532 nm light.
  • the differential in absorption coefficients between oxyhemoglobin and water at 532 nm is approximately 5 orders of magnitude (10 5 ).
  • wavelengths in the range from 200 nm-650 nm are used, which have strong oxyhemoglobin absorption and relatively weak water absorption (>10 2 ⁇ ). In yet other embodiments, wavelengths in the range from 200 nm to 650 nm range are used, which have strong oxyhemoglobin absorption and relatively weak water absorption (>10 ⁇ ).
  • alternative pump power sources such as arc lamps 28 , and flash lamps, other lasers for longitudinal pumping, and others, can be used as suits the needs of a particular gain medium and application of the laser system.
  • the laser systems shown in FIGS. 5 and 6 can be modified by removing both the Q-switch and the external surgical attenuator.
  • the Q-switch and surgical attenuator are removed because the modulated pump power provides a great deal of flexibility in controlling the output power of the laser not attainable using a Q-switch.
  • the data processing system can be programmed to maintain a constant thermal load in the laser system while varying the peak pump power widely.
  • the peak current and duty cycle of the pump power source can be adjusted in such a way to keep the average pump power constant, but the second harmonic power during the ready and work modes adjusted by selecting the peak current and duty cycle.
  • Attenuators may well be eliminated for the work mode.
  • the average power does not have to be constant, rather it can be maintained at levels which keep thermal focusing of the gain medium within the range of stability of the resonator.
  • a representative laser system adapted for delivery of energy as described above comprises an 80 watt average power, 532 nm output wavelength, solid state, intra-cavity frequency doubled Nd:YAG laser.
  • an arc lamp pump source is modulated at a period of 4.5 ms with a 16 ms duty cycle, generating 285 watts peak macro-pulse power.
  • An intra-cavity acousto-optic AO Q-switch is used to further modulate the energy at a period of 40 kHz with a 450 us micro-pulse.
  • the laser energy is coupled to a side firing fiber optic delivery device for delivery to uterine tissue.
  • the laser system uses a combination touch screen and control knob user interface to assist the operator in setting up the surgical parameters, including power levels and pulse sequence specifications.
  • the average power setting is prominently displayed on the screen.
  • Parameter adjustments are made by first activating (touching) the desired parameter box on the screen and then turning the knob.
  • the laser system uses a secure card key interface to enable the laser.
  • the system is transportable. The system offers convenient storage and a fiber delivery device pole.
  • FIG. 7 An example of an endoscope, in particular a hysteroscope, for use with the present invention is shown in FIG. 7 .
  • the hysteroscope has a distal end 200 and a proximal end 201 .
  • Laser radiation 205 is directed from and end firing fiber through an opening 206 , by a fiber optic component.
  • Water, Ringer Lactate or saline solution is delivered and removed from the treatment area via lumens in the probe.
  • a viewing optic is also placed in the opening 206 , by which the surgeon is able to view the treatment area during the procedure.
  • an irrigation port 203 for flow of the irrigant is provided on the proximal end 201 of the endoscope.
  • a fiber port 207 is used for insertion and removal of the fiber optic delivering laser radiation to the treatment area.
  • a light source connector 209 is used for supplying light to the treatment area for visualization.
  • An viewing port 211 which can be coupled to a video camera, or looked into directly, is also included on the representative hysteroscope.
  • the endoscope includes a flexible tip in one embodiment, and controls (not shown) in the near proximal end 201 , by which the surgeon deflects and guides the positioning of the tip at distal end 200 . Representative systems for providing flexible tip endoscopes are described in U.S. Pat. No. 4,802,461, and are widely used for surgical procedures.
  • the vaporization of uterine tissue using oxyhemoglobin as the primary chromophore is related to the incident power density, or irradiance, which can be expressed in Watts/cm 2 .
  • the overall rate of uterine tissue vaporization is a function of the spot size, absorption depth, and the power density. A large spot with high power density, and rapid absorption is ideal to rapidly vaporize tissue. A high power light source is required to achieve a large spot, high power density treatment beam. Peak laser power, average laser power, beam quality, delivery device design and delivery device placement all affect the efficiency of vaporization.
  • FIGS. 8 and 9 illustrate the different optical penetration depths of the 532 nm wavelength and 1064 nm wavelength used in prior art procedures. See, S. L. Jacques. Laser - tissue interaction. Photochemical, photothermal, and photomechanical . Surg. Clin N. Am. 1992; 72(3): 531-558.
  • the optical penetration depth of the 1064 wavelength beam from Nd:YAG laser beam is about 10 mm, which is 13 times larger than the penetration depth of the second harmonic 532 wavelength laser beam, which is about 0.8 mm.
  • the 1064 laser power is spread out over a much larger tissue volume than the power of the KTP laser.
  • the temperature at the tissue surface barely reaches 100° C. Therefore, only a small portion of tissue gets vaporized. But a huge volume of tissue gets coagulated (see space between 100° C. and 60° C. isotherm).
  • the 532 laser beam in contrast, is substantially completely absorbed within less than about 1 mm of the surface of uterine tissue.
  • the laser power is confined to a very small tissue volume.
  • the high volumetric power density results in a fast heating of the tissue and efficient tissue vaporization.
  • Volumetric power density delivered to tissue is a function of the absorbtion depth, irradiance in Watts/cm 2 and spot size on the surface of the tissue.
  • the coagulation zone is very thin because of the small optical penetration depth of the 532 wavelength, and because substantially all of the radiation is converted to vaporization rather than residual heat.
  • wavelengths which are substantially completely absorbed within less than about 1 mm of the surface of the uterine tissue include wavelengths between about 200 and 1000 nm, including wavelengths less than about 700 nm, for example between about 200 nm and 650 nm.
  • FIGS. 10 and 11 illustrate a profile of a beam delivered to tissue using one representative side firing optical fiber, to show spot size as a function of distance from the side of the optical fiber.
  • FIG. 10 is an end view, showing a fiber 600 , cladding 601 on the fiber, an air space 602 , and a tip 603 through which the beam is directed by a reflecting face on the fiber.
  • the cross-section of the beam is represented by the crossing lines 604 and 605 .
  • the beam has a width in this dimension of about 0.35 mm at 1 mm from the side of the tip 603 . At about 2 mm from the side of the tip 603 , the width is about 1 mm. At about 3 mm distance from the side of the tip 603 , the beam width is about 2.2 mm.
  • FIG. 11 is a side view, with like components given the same reference numbers.
  • the beam width in this dimension is represented by lines 606 and 607 .
  • the beam has a width in this dimension of about 0.7 mm at 1 mm from the side of the tip 603 .
  • the width is about 1 mm.
  • the beam width is about 1.5 mm.
  • the spot size at 1 mm from the side of the tip is defined basically by an ellipse having a major axis of 0.7 mm, and a minor axis of 0.35 mm.
  • the area of the spot at 1 mm is around 0.2 mm 2 .
  • the area of the spot is about 0.8 mm 2 .
  • the spot size should be large enough that the operator can remove tissue at a reasonable rate, and see the results of a single pass of the spot over a region of tissue. If the spot size is too small, the rate of the operation is too slow. Also, if the spot size is too big, then the procedure is difficult to control precisely.
  • a preferred spot size is less than about 1 mm 2 , and more particularly between about 0.8 mm 2 and about 0.05 mm 2 .
  • Other apparatus may be used for delivery of the beam with the desired spot size, including embodiments without diverging beams, and embodiments with converging beams.
  • the irradiance of the beam at 1 mm from the side of the tip for an 80 W average power laser as described above is about 30 kiloWatts/cm 2 .
  • FIG. 12 shows, heuristically, how vaporization rate and coagulation rate depend on the volumetric power density.
  • the vaporization rate (in mm/s) is defined as tissue depth that is vaporized per time interval.
  • the coagulation rate (in mm/s) is defined as the depth of residual coagulated tissue that remains after a certain time of vaporization.
  • vaporization threshold Below a certain volumetric power density, referred to as a “vaporization threshold” in FIG. 12 , no tissue gets vaporized. All laser energy stays inside the tissue. Tissue coagulation occurs where the tissue temperature rises above approximately 60° C. As the volumetric power density is increased a bigger and bigger tissue volume gets coagulated.
  • the vaporization threshold At the vaporization threshold, vaporization starts. Above the vaporization threshold the vaporization rate can be considered to increase linearly with the volumetric power density for the purpose of understanding the present invention, and as described by a steady state model for continuous wave laser tissue ablation, known by those familiar with the art of laser-tissue interaction.
  • VLAP visual laser ablation of the prostate
  • Nd:YAG laser at 1064 nm
  • Histology studies have shown that the 1064 nm laser induces deep coagulation in the tissue that results in edema and delayed tissue sloughing. This effect was described by Kuntzman, et al., High - power potassium titanyl phosphate laser vaporization prostatectomy . Mayo Clin Proc 1998: 73: 798-801.
  • the VLAP procedure is believed to lie around point 650 , barely above the vaporization threshold.
  • the ablation rate further increases and the coagulation rate further drops, so that the procedure lies heuristically at point 652 in FIG. 12 .
  • a 80 Watt KTP laser can be used to easily reach irradiance levels that vaporize substantially more tissue than is left as residual coagulation after the procedure. More precisely, the vaporization rate is substantially higher than the coagulation rate as given by the definition above, using high irradiance levels that are easily achieved with higher power lasers. Because of higher vascularization in the uterus, the optical penetration depth is lower than in prostatic tissue, and therefore the volumetric power density at the vaporization threshold can be easily reached with lower average power lasers, including for example a 40 W average output power laser.
  • FIG. 13 illustrates a uterus, generally 500 , having myomas treatable according to the present invention, including intracavitery protruding myomas 501 , 502 , intracavitery pedunculated myoma 503 , and intramural, submucosal myoma 540 .
  • Myoma 502 is located in the right cornu.
  • Hysteroscope 505 is positioned through the cervix 506 with a flexible tip 507 adjacent myoma 502 , and delivering laser radiation as described above.
  • FIG. 14 illustrates use of a side firing probe 509 for treatment of a myoma 510 located in one of the uterine cornua.
  • FIG. 15 illustrates use of an end firing probe 511 , for treatment of a myoma 512 located in one of the uterine cornua.

Abstract

A method for photoselective vaporization of uterine tissue includes delivering laser radiation to the treatment area on the tissue, via an optical fiber for example, wherein the laser radiation has a wavelength and irradiance in the treatment area on the surface of the tissue sufficient because vaporization of a substantially greater volume of tissue than a volume of residual coagulated tissue caused by the laser radiation. The laser radiation is generated using a neodymium doped solid-state laser, including optics producing a second or higher harmonic output with greater than 60 watts average output power. The delivered laser radiation has a wavelength for example in a range of about 200 nm to about 650 nm, and has an average irradiance in the treatment area greater than about 10 kilowatts/cm2, in a spot size of at least 0.05 mm2.

Description

    RELATED APPLICATION INFORMATION
  • This application is a divisional application of U.S. patent application Ser. No. 10/371,080 filed 21 Feb. 2003.
  • Application Ser. No. 10/371,080 claims the benefit of U.S. Provisional Application No. 60/358,356, entitled METHOD FOR TREATMENT OF GYNECOLOGICAL CONDITIONS USING A HIGH POWER LASER IN CONJUCTION WITH A HYSTEROSCOPE, filed 22 Feb. 2002.
  • The present application is related to, and incorporates by reference as if fully set forth herein, U.S. patent application Ser. No. 10/278,723, entitled METHOD AND SYSTEM FOR PHOTOSELECTIVE VAPORIZATION OF THE PROSTATE, AND OTHER TISSUE, filed 23 Oct. 2002; U.S. patent application Ser. No. 09/737,721, entitled METHODS FOR LASER TREATMENT OF SOFT TISSUE, filed 15 Dec. 2000 (now U.S. Pat. No. 6,554,824); and U.S. patent application Ser. No. 10/279,087, entitled METHOD AND SYSTEM FOR TREATMENT OF BENIGN PROSTATIC HYPERTROPHY (BPH), invented by Murray, et al.; filed: 23 Oct. 2002.
  • BACKGROUND OF THE INVENTION
  • 1. Field of the Invention
  • The present invention relates generally to laser treatment of tissue, and more particularly to photoselective vaporization of tissue, including uterine tissue, as applied to the treatment of gynecological conditions.
  • 2. Description of Related Art
  • A commonly employed procedure for removal of tissue in the treatment of gynecological conditions involves the use of a hysteroscope and a small wire loop energized by radio frequency energy to cut tissue.
  • Nd:YAG lasers delivering output with a wavelength of 1064 nm have been used for the treatment of gynecological conditions such as the ablation of the endometrium. Although 1064 nm light is hemostatic at high power levels, its low absorption in blood and uterine tissue leads to inefficient ablation and a large residual layer of thermally denatured tissue several millimeters thick.
  • High power densities are required for rapid and efficient vaporization of tissue. The difficulty of achieving higher average output power densities is that when high input powers are supplied to the laser element from an excitation source such as an arclamp a large amount of heat is generated in the lasing element. This heat induces various deleterious effects in the lasing element. In particular the temperature difference between the coolant and the hot lasing element generates a thermally induced graded index lens that decreases the beam quality of the laser and causes the laser to operate with more transverse optical modes than it would otherwise.
  • The M2 parameter is a well established convention for defining the beam quality of a laser and is discussed in pages 480-482 of Orazio Svelto and David C. Hanna, Principles of Lasers, Plenum Press, New York, 1998, which is incorporated herein by reference. The beam quality measures the degree to which the intensity distribution is Guassian. The quantity M2 is sometimes called inverse beam quality rather than beam quality but in this application it will be referred to as beam quality. M2 is defined as M x 2 ( σ x σ f ) NG ( σ x σ f ) G = 4 π ( σ x σ f ) NG ,
      • where π refers to the number 3.14 . . . , σ is used to represent the spot size, the subscripts x and f represent the spatial and frequency domains along the x-axis, respectively, and the subscripts G and NG signify Guassian and non-Guassian, respectively. The x-axis is transverse to the direction of propagation of the beam. The beam quality in any direction transverse to the beam may be essentially the same. Therefore the subscript x is dropped from the M2 elsewhere in the specification. The beam widths or σs are determined based on the standard deviation of the position, where the squared deviation of each position is weighted by the intensity at that point. The beam width in the frequency domain σf is the beam width of the beam after being Fourier transformed.
  • The formula usually used for calculating the angular divergence, θ, of a beam of light of wavelength λ is strictly valid only for a beam having a Guassian intensity distribution. The concept of beam quality facilitates the derivation of the angular divergence, θ, for the beam with a non-Guassian intensity distribution, according to θ = M 2 ( 2 λ π σ x ) .
  • For example, a TEM00 laser beam has a high beam quality with an M2 of 1, whereas by comparison, high power surgical lasers operate with M2 values greater than 100.
  • The Applicants have recognized that high power lasers typically have an M2>144. The larger number of modes makes M2 larger and makes it difficult to focus the light into small, low numerical aperture fibers and reduces the ability to project high power density light onto tissue. As a result, the vaporization efficiency of CW arclamp pumped 532 nm lasers is significantly reduced.
  • Surgical procedures within the uterus have unique risks. For example, precision surgery is of high importance for patients who want to maintain their fertility. Any surgery in the uterus must avoid weakening of the wall of the uterus, which could lead to complications during pregnancy. Also, the physiological diversity of the uterus increases the difficulty of intrauterine operations. The cornual areas of the uterus represent a vulnerable portion of the uterus. In case of a myoma in the cornu, the uterine wall is further thinned by the myoma, which increases the risk of intraoperative perforation of the uterine wall. Even if perforation does not occur, the presence of a thin uterine wall could predispose the patient to bowel injury. As stated by Indman, J. Reproduct. Med. 1991, lack of precise knowledge of the minimum thickness of the uterine wall may be the limiting factor in determining the safety of use of the 1064 nm Nd:YAG laser for endometrial ablation.
  • SUMMARY OF THE INVENTION
  • Photoselective vaporization of tissue, such as tissue subject of removal for treatment of gynecological conditions, is based upon applying a high intensity radiation to tissue using a radiation that is highly absorptive in the tissue, while being absorbed only to a negligible degree by water or other irrigant during the operation, at power densities such that the majority of the energy is converted to vaporization of the tissue without significant residual coagulation of adjacent tissue.
  • The present invention provides a method for treating gynecologic conditions, including conditions involving uterine tissue, such as intramural and intracavitery uterine myomas, leiomyoma uteri, rhabdomyoma, endometriosis, endometrial hyperplasia, endometrial cysts, endometrial polyps, menorrhagia, uterine septa, intrauterine adhesions, or cervical intraepithelial neoplasia. Other gynecological conditions involving the female reproductive organs such as the fallopian tubes, the ovaries, and the vagina, are also treatable according to the present invention. Treatment according to the embodiments of present invention is executed by vaporizing, incising, or coagulating tissue, such as uterine tissue, using a laser that generates light with an average power greater than 40 watts and a wavelength between 300 and 700 nm where the output beam of the laser is delivered to the target tissue through an optical waveguide, such as an optical fiber that emits light in forward direction (end-firing) or in a laterally directed manner (side-firing) where laterally means at an angle of 10°-170° with respect to the fiber axis, and where the waveguide is guided into the vagina or the uterine cavity using a hysteroscope. In embodiments of the invention, the hysteroscope is equipped with a rigid tip. In other embodiments of the invention, the hysteroscope is equipped with a flexible tip, which can be manipulated by the surgeon, allowing greater control over the procedure, and access to more regions of the target tissue.
  • In other embodiments, the wavelength of the delivered radiation is between 1100 and 1800 nm, or in other bands that are efficiently absorbed by the target tissue.
  • Yet other embodiments employ a laser system, that generates light of two wavelengths, with for example two lasers arranged to provide light to a beam delivery system, with the light of the first wavelength having an average power greater than 40 watts, and in some embodiments more than 60 Watts, and a wavelength between 300 and 700 nm, such as a wavelength of 532 nm, and the light of the second wavelength having a wavelength of 1064 nm. In alternative one or two wavelength systems, delivered light is between 1100 and 1800 nm.
  • According to one embodiment of the invention, a method for treating gynecological conditions comprises the steps of providing a solid-state laser having a laser element positioned to receive pump radiation from an excitation source; in some cases modulating the source to cause the laser to emit pulsed laser light; and delivering the laser light to targeted tissue. Various solid-state lasers may be used for this purpose, including (without limitation), a Q-switched laser using a frequency doubling crystal such as potassium-titanyl-phosphate (KTP), pumped using a diode array, an arc lamp or a flash lamp. While Q-switching induces short, “micro-pulses,” a “macro-pulse” duration of the laser light is preferably in the range of 0.1 to 500 milliseconds, induced by for example modulating the pump energy with the desired macro-pulse length. The wavelength of the laser light is preferably between 200 and 1000 nm, and more preferably between about 300 and 700 nm. The laser light is preferably delivered to the targeted tissue through an optical fiber terminating at or near a distal end in a side-firing or end-firing probe.
  • Operation of the solid-state laser in a “macro-pulsed” mode is more efficient in vaporizing tissue than a CW laser of the same average power. This is in part because the heat generated in a superficial tissue layer, which depth is defined by the optical penetration depth of the laser beam, doesn't have time to significantly diffuse into deeper tissue layers during each macro pulse. The heat stays confined in the superficial tissue layer and leads to a rapid heating of the tissue to the boiling point of water. The thermal energy generated within a tissue volume has to exceed the vaporization enthalpy of water to fully vaporize the tissue. For a laser operated in a macro-pulsed mode this condition is met for a larger tissue volume than for a laser operated in a continuous mode. The macro-pulsed laser is also more efficient and has higher beam quality, with M2 values typically less than 144, than a continuous wave laser with same average output power. The higher beam quality allows for higher irradiances on the tissue and thus a more rapid tissue vaporization.
  • According to a second embodiment of the invention, a method for treating uterine tissue comprises the steps of providing a solid-state laser having a laser element positioned to receive pump radiation from a pump radiation source; modulating the pump radiation source to cause the laser element to emit laser light having a pulse duration of between 0.1 milliseconds and 500 milliseconds and an average output power exceeding 20 watts; and delivering the laser light to targeted tissue.
  • According to a third embodiment of the invention, a method for treating gynecological conditions comprises the steps of providing a solid-state laser having a laser element positioned to receive pump radiation from a pump radiation source; Q-switching the laser to generate a quasi-continuous wave (CW) beam having an average output power exceeding 60 watts; and, delivering the beam to targeted tissue.
  • According to a fourth embodiment of the invention, a method for treating gynecological conditions comprises the steps of providing a solid-state laser having a laser element positioned to receive pump radiation from a pump radiation source such as a laser diode; Q-switching the laser to generate a quasi-continuous wave (CW) beam having an average output power exceeding 20 watts with an M2 less than 144; and delivering the beam to uterine tissue.
  • It has been recognized that as more and more laser energy is consumed by vaporization of the tissue, the amount of laser energy leading to residual tissue coagulation gets smaller, i.e. the amount of residual coagulation drops, and the side effects attendant to the residual injury caused by the surgery drop dramatically. Thus, the extent of the zone of thermal damage characterized by tissue coagulation left after the procedure gets smaller with increasing volumetric power density, while the rate of vaporization increases. Substantial and surprising improvement in results is achieved. It has been recognized that increasing the volumetric power density absorbed in the tissue to be ablated, has the result of decreasing the extent of residual injury of the surrounding tissue. This recognition leads to the use of higher power laser systems, with greater levels of irradiance at the treatment area on the tissue, while achieving the lower levels of adverse side effects and a quicker operation times.
  • Although the invention can be generalized other types of tissue, one embodiment of the invention provides a method for photoselective vaporization of uterine tissue, including for example the endometrium and myomas in the uterine wall. According to this embodiment, the method includes delivering laser radiation to the treatment area on the tissue, via an optical fiber for example, wherein the laser radiation has a wavelength and irradiance in the treatment area on the surface of the tissue sufficient because vaporization of a substantially greater volume of tissue than a volume of residual coagulated tissue caused by the laser radiation. In one embodiment, the laser radiation is generated using a neodymium doped solid-state laser, including optics producing a second or higher harmonic output with greater than 60 watts average output power, and for example 80 watts average output power, or more. The laser radiation is coupled into an optical fiber adapted to direct laser radiation from the fiber to the treatment area on the surface of the tissue. For the treatment within the uterus, the fiber optic is inserted via hysteroscope, including lumens for delivering irrigants to the treatment area, and for direct visualization during the treatment. For treatment in the uterine cornua, or other difficult to reach regions, and more generally because of physiological diversity in the uterus, a flexible tip hysteroscope is used in embodiments of the present invention.
  • In other embodiments, the delivered laser radiation has a wavelength in a range of about 300 nm to about 700 nm, and has an average irradiance in the treatment area greater than about 10 kilowatts/cm2, in a spot size of at least 0.05 mm2. More preferably, the irradiance is greater than about 20 kilowatts/cm2, and even more preferably greater than about 30 kilowatts/cm2. The spot size in preferred systems is for example less than about 0.8 mm2.
  • Accordingly, in one embodiment, the second harmonic output of the neodymium dope solid-state laser is applied using an optical fiber with a flat tip for emitting radiation from the end, or with a side-firing tip. When using a side-firing tip, which causes a diverging beam to be directed out of the optical fiber, the time is placed close to the tissue, within about 1 mm from the side of the side-firing tip to contacting the side of the tip. Close placement increases the irradiance delivered to the treatment area so that higher irradiance is available with solid-state lasers generating a 60 to 80 watts average output power.
  • According to the present invention, the efficiency of the vaporization and the reduction of injury to residual tissue are sufficient that the procedure may be carried out while applying less anesthesia during the delivery of laser energy, and throughout the procedure, than during other procedures. Anesthesia options for a procedure according to the present invention include, but are not limited to, paracervical block, and general or regional anesthesia techniques.
  • Furthermore, embodiments of the invention include the delivery of the laser energy using a Q-switched, solid-state laser which produces micro-pulses in combination with applying pump power to the laser medium in a sequence a pulses so that output radiation is produced in macro-pulses having a peak power of greater than 200 watts, and more preferably about 240 watts or greater. The peak irradiance in the treatment area during the pulses is thereby substantially increased, and preferably greater than 50 kilowatts/cm2, and as much as 90 kilowatts/cm2 in some embodiments of the invention.
  • Other aspects and advantages of the present invention can be seen on review the figures, the detailed description, and the claims which follow.
  • BRIEF DESCRIPTION OF THE DRAWINGS
  • FIG. 1 depicts a laser system for implementing the tissue ablation methods of the invention;
  • FIG. 2 depicts a side-firing probe for use with the system of FIG. 1;
  • FIG. 3 depicts an exemplary output waveform of the FIG. 1 laser when the laser is operated in a macro-pulsed mode; and
  • FIG. 4 depicts an exemplary output waveform of the FIG. 1 laser when the laser is operated in a quasi-CW mode.
  • FIG. 5 is a block diagram of a laser system adaptable for use according to the present invention.
  • FIG. 6 is a block diagram of an alternative laser system adaptable for use according to the present invention.
  • FIG. 7 is a diagram of a flexible tip hysteroscope, adaptable for use according to the present invention.
  • FIG. 8 illustrates absorption depth in tissue for 532 nm light.
  • FIG. 9 illustrates absorption depth in tissue for 1064 nm light.
  • FIG. 10 is a diagram of a beam path from an end view of a side firing tip, according to one embodiment of the present invention.
  • FIG. 11 is a diagram of a beam path from a side view of the side firing tip of FIG. 10, according to one embodiment of the present invention.
  • FIG. 12 is a heuristic diagram illustrating operation of the present invention.
  • FIG. 13 illustrates representative gynecological conditions treatable according to the present invention.
  • FIG. 14 illustrates application of a side-firing probe on a hysteroscope for ablation of tissue in treatment of a protruding, intracavitery uterine myoma within the right uterine cornu.
  • FIG. 15 illustrates application of an end-firing probe on a flexible tip hysteroscope for ablation of tissue in treatment of a protruding, intracavitery uterine myoma.
  • DETAILED DESCRIPTION
  • FIG. 1 is a block diagram depicting an exemplary laser system 100 which may be employed for implementing the present invention. Laser system 100 includes a solid-state laser 102, which is used to generate laser light for delivery through optical fiber 106 to target tissue 104. As will be discussed in further detail herein below, laser 102 is capable of being operated in a “macro-pulsed” mode, wherein the laser light is emitted as macro-pulses having relatively long pulse durations.
  • Laser 102 more specifically comprises a laser element assembly 110, pump source 112, and frequency doubling crystal 122. In the preferred embodiment, laser element 110 outputs 1064 nm light which is focused into frequency doubling crystal 122 to create 532 nm light. According to one implementation, laser element assembly 110 may be neodymium doped YAG (Nd:YAG) crystal, which emits light having a wavelength of 1064 nm (infrared light) when excited by pump source 112. Laser element 110 may alternatively be fabricated from any suitable material wherein transition and lanthanide metal ions are disposed within a crystalline host (such as YAG, Lithium Yttrium Fluoride, Sapphire, Alexandrite, Spinel, Yttrium Orthoaluminate, Potassium Gadolinium Tungstate, Yttrium Orthovandate, or Lanthanum Scandium Borate). Laser element 110 is positioned proximal to pump source 112 and may be arranged in parallel relation therewith, although other geometries and configurations may be employed.
  • Pump source 112 may be any device or apparatus operable to excite laser element assembly 110. Non-limiting examples of devices which may be used as pump source 112, include: arc lamps, flashlamps, and laser diodes.
  • A Q-switch 114 disposed within laser 102 may be operated in a repetitive mode to cause a train of micro-pulses to be generated by laser 102. Typically the micro-pulses are less than 1 microsecond in duration separated by about 40 microseconds, creating a quasi-continuous wave train. Q-switch 114 is preferably of the acousto-optic type, but may alternatively comprise a mechanical device such as a rotating prism or aperture, an electro-optical device, or a saturable absorber.
  • Laser 102 is provided with a control system 116 for controlling and operating laser 102. Control system 116 will typically include a control processor which receives input from user controls (including but not limited to a beam on/off control, a beam power control, and a pulse duration control) and processes the input to accordingly generate output signals for adjusting characteristics of the output beam to match the user inputted values or conditions. With respect to pulse duration adjustment, control system 116 applies an output signal to a power supply (not shown) driving pump source 112 which modulates the energy supplied thereto, in turn controlling the pulse duration of the output beam.
  • Although FIG. 1 shows a frequency doubled laser with an intracavity frequency doubling element, it is only by way of example. The infrared light can be internally or externally frequency doubled using non-linear crystals such as KTP, Lithium Triborate (LBO), or Beta Barium Borate (BBO) to produce second harmonic 532 nm green light, and higher harmonics. The frequency doubled, 532 nm wavelength and the shorter wavelength higher harmonic beams are better absorbed by the tissue, and promote more efficient tissue ablation.
  • In one preferred embodiment the resonant cavity control system is that described in U.S. Pat. No. 5,151,909, which is incorporated by reference as if fully set forth herein.
  • Laser 102 further includes an output port couplable to optical fiber 106. Output port 118 directs the light generated by laser 102 into optical fiber 106 for delivery to tissue 104. Mirrors 124, 126, 128, and 130 direct light from the lasing element 110 to the frequency doubling crystal 122, in addition to forming the resonant cavity of the laser. Mirrors 124, 126, 128, and 130 are configured for focusing the light to form an image just in front of the frequency doubling crystal 122 on the side closer to mirror 130, and to compensate for thermal lensing in the lasing element. Although mirrors 124, 126, 128, and 130 are illustrated as flat and parallel to the walls of the laser, typically the focusing is achieved by curving and/or angling the mirrors. Alternatively transmissive optical elements could be used to focus the light and compensate for the thermal imaging. Mirrors 124, 128 and 130 reflect both the wavelength of light produced by the lasing element (e.g. 1064 nm) and the wavelength of the frequency doubled light (e.g. 532 nm). Mirror 126 only reflects the light originating from the lasing element 110 (e.g. 1064 nm) but is transparent to the frequency doubled light (e.g. 532 nm), forming an output window. Higher harmonic outputs may also be generated from the 1064 nm line, or other line amplified in the laser, including third and fourth harmonics, for shorter wavelengths. Other laser systems may be used, including but not limited to Sapphire lasers, diode lasers, and dye lasers, which are adapted to provide the output power and wavelengths described herein, including wavelengths in the ranges from 200 nm to 1000 nm and from 1100 nm to 1800 nm, for example.
  • While a bare fiber may be utilized for certain procedures, optical fiber 106 preferably terminates in a tip 140 having optical elements, or otherwise adapted, for shaping and/or orienting the beam emitted by optical fiber 106 so as to optimize the tissue ablation process.
  • FIG. 2 depicts a side-firing probe tip 200, which may be used as tip 140 (FIG. 1). The tip 140 is treated to deflect light sideways. Some examples of methods for deflecting the light sideways are to include a light scattering material in the tip 140 and/or to place a reflective element in the tip 140. The reflective element could be angled at 45°, for example; to deflect the light at 90° with respect to the axis of the fiber 106. Side-firing probe tip 200 includes an optically transparent sleeve 202 having a transparent window 204 (which may be constructed as a cutout in the wall of sleeve 202 through which the beam is emitted in a direction transverse to the optical axis of fiber 106.) An acceptable range of angles in which to deflect the light beam is between about 40 to 120 degrees with respect to the axis of the fiber. The preferred embodiments use an angle of either 70 or 100. The angle of 80° is preferred from the standpoint of the ease in manufacturing the tip 200 and the angle of 90° is preferred from the standpoint of the ease in aiming the side firing light.
  • In a typical mode of operation, optical fiber 106 is held within an endoscope such as a hysteroscope or similar instrument that allows the clinician to precisely position the distal end of the optical fiber adjacent to the targeted tissue. The endoscope also has channels for supplying and removing an irrigant solution to and from the tissue. In addition, light and image guides are also included for illuminating and imaging the tissue so that the clinician may direct the laser light and assess the progress and efficacy of the ablation procedure. Physiologic saline solution, typically containing 0.9% sodium chloride, is used as the irrigant in gynecological procedures according to the present invention.
  • FIG. 3 illustrates an exemplary output waveform applied to tissue 104 when laser 102 is operated in the macro-pulsed mode. Each macro-pulse 302 is defined by a train of Q-switched micro-pulses 304. While a relatively small number of micro-pulses 302 are depicted for purposes of clarity, an actual macro-pulse may comprise hundreds or thousands of component micro-pulses 304. In the preferred embodiment there are between 2 and 12,200 micro-pulses per macro-pulse.
  • An arc lamp, for example, when used as the pump source 112, is kept at a low power level between pulses that are preferably just enough to maintain the arc. These low pump powers are below the lasing threshold of the laser; as a consequence, there is no laser output between macro-pulses.
  • As mentioned above, the pulse duration or width D (FIG. 3) of the output beam is governed by the modulation of pump source 112, and more specifically by the period during which the pump source 112 is maintained in an “on” or high-power condition. In other words, the longer the pump source 112 is maintained in an on condition, the longer the pulse width. Typically, laser 102 will be capable of delivering pulses 302 having pulse durations D in the range of 1 to 20 milliseconds (2 to 490 micro-pulses) or 1 to 50 milliseconds (2 to 1,220 micro-pulses) and average output powers preferably exceeding 60 watts and preferably up to 100 or 200 watts. The ratio of D to the period of the macro-pulses defines the duty cycle, which is typically between 10 and 50%.
  • In accordance with one embodiment of the invention, a laser system 100 of the foregoing description is employed to treat gynecological conditions by ablating targeted tissue 104. The clinician may utilize an endoscope or similar instrument to guide the distal end and tip 140 of optical fiber 106 into alignment with the targeted tissue 104. Laser system 100 is then operated in the macro-pulsed mode so that laser 102 generates laser light having the pulsed waveform depicted in FIG. 3 and delivers it through optical fiber 106 to tissue 104.
  • Prior art techniques for treatment of gynecological conditions by laser ablation (such as the technique described by Indman. in “High-Power Nd:YAG Laser Ablation of the Endometrium,” Journal of Reproductive Medicine, Vol. 36, No. 7, July 1991)) utilized an Nd:YAG laser to irradiate the uterine tissue. Although such lasers do produce moderately high average powers, they have a large number of transverse modes and as such, produce highly divergent light when focused into small fiberoptics. Further, the 1064 nm wavelength is less efficiently absorbed in the target tissue, that the wavelengths desirable according to the present invention. These characteristics of prior art 1064 nm systems lead to less than optimal power densities when the laser light is directed at tissue. As a consequence, ablation rates are relatively slow, significantly lengthening procedure times. Further, undesirable thermal damage to deeper tissue layers may occur. In contrast, it has been found that a macro-pulsed beam, such as that generated by laser 102, helps to accelerate ablation rates and reducing procedure time.
  • The macropulsing can also increase efficiency because the threshold voltage required for lasing while macropulsing (the operating threshold) is lower than the initial threshold voltage for lasing (cold threshold).
  • Macropulsing is also more efficient for producing green light because the conversion of infrared light to frequency doubled light increases as the square of the infrared light intensity. The higher peak powers of the macro-pulsed infrared light leads to higher second harmonic conversion efficiency. For example, at any given time, the input power and output power of a frequency-doubled laser using KTP are related according to
    Po=A(Pi)2,
  • Where A is an experimentally determined positive constant. This equation relates the peak input power to the peak output power. However, the average input power and output power for a duty cycle of k percent are given by
    <Pi>=k(Pi) and
    <Po>=k(Po)=kA(Pi)2 =A(<Pi>)2 /k,
    where the brackets “< >” indicate an average value of the enclosed quantity. Thus, decreasing the duty cycle from 100% to 50% (i.e. reducing k from 1 to 0.5) while simultaneously doubling the peak input power Pi results in no change to the average input power <Pi> and a doubling of the average output power <Po>. Pulse modulating or macropulsing using Q-switching, for example, enables reaching higher average output powers with less thermal lensing due to the lower input power.
  • Additionally, it is possible that the frequency doubling crystal has nonlinearly increasing output power as a function of the input power. In other words the second derivative of the output power with respect to the input power may be positive, in which case the rate of increase of the output power increases with increasing input power. Specifically, in such a case the functional dependence of the instantaneous or peak output power, Po, on the instantaneous or peak input power, Pi, is such that
    d 2(Po)/d(Pi)2>0.
    When this is true, and Po is an increasing function of Pi, the higher peak input power results in a more efficient laser because ratio of the output to input power increases.
  • Pump source modulation of the laser can produce high peak power macro-pulses and affect the efficiency of the average power output. Macro-pulse in excess of a steady state power can substantially improve the initiation of the vaporization of tissue. The higher peak power of the macro-pulse rapidly may initiate charring which in turn serves as an additional chromophore for the incident energy and enhances the vaporization rate. A 30% macro-pulse duty cycle is sufficient to increase the average power output of an arc lamp pumped laser to greater than 80 watts. Additionally the pump modulation generates macro-pulse with pulse powers greater than 240 watts.
  • By way of a non-limiting example, tissue 104 may be efficiently and rapidly ablated when laser 102 is operated at an output power of 80 to 100 watts, a pulse duration of 1-50 milliseconds, and a wavelength of 532 nm.
  • In accordance with a second method embodiment of the invention, laser system 100 may be utilized to ablate other types of tissue 104 involved in gynecological conditions. The clinician may utilize an endoscope or similar instrument to guide the distal end and tip 140 of optical fiber 106 into alignment with the tissue 104. Laser system 100 is then operated in the macro-pulsed mode so that laser light having the pulsed waveform depicted in FIG. 3 is generated by laser 102 and delivered through optical fiber 106 to tissue 104. To achieve adequate results, laser system 100 is adjusted to emit a beam having a pulse duration between 0.1 and 500 milliseconds, and an output power of at least 20 watts. Upon vaporization of the required volume of tissue 104, (which may be assessed via an imaging channel contained in the endoscope), the output beam of laser 102 is turned off.
  • In a third method embodiment of the invention, treatment of gynecological conditions is effected by operating laser 102 in a quasi-CW mode at an output power greater than 60 watts. The increased denaturization of the tissue is dramatic with increases in power, suggesting a threshold effect. As depicted in FIG. 4, laser 102 generates a continuous train of Q-switched micro-pulses 400 when operated in quasi-CW mode. The laser light is then delivered via optical fiber 106 to targeted tissue 104. Operation in a quasi-CW mode at powers above 60 watts facilitates formation of char and consequent rapid ablation rates, whereas operation in a quasi-CW mode at powers below 60 watts forms char more slowly and causes more thermal damage to underling tissue.
  • A fourth embodiment of this invention is to produce a high power, high beam quality laser that can project high power density laser light onto tissue. To do this the number of transverse optical modes supported by the resonator needs to be kept as low as possible.
  • Small M2 and high average powers can be achieved by reducing the degree of thermal lensing in the laser element. Using laser diodes as the excitation source is one effective way of greatly reducing both the size of the lasing element and the thermal gradient responsible for creating the thermal lens. The reason for this is that while 2-10% of the light produced from a flashlamp or arc lamp is converted into useful laser light 30-60% of the light emitted from laser diodes can be converted to laser light. Since the energy that is not converted to laser light is converted into heat, laser diodes deposit significantly less heat in the lasing element and as a consequence create a less powerful thermal lens. In this manner laser diodes can be used to pump crystalline laser elements or fiber lasers to produce high beam quality lasers. Slab and waveguide lasers that can be pumped by laser diodes, arc lamps, or flashlamps are another method of creating low M2 lasers. This is because the thermal gradient produced in slab lasers is linear across the thin dimension of the slab and not radially dependent in contrast to a typical cylindrical lasing element. The linear thermal gradient does not produce a thermal lens resulting in low M2 values.
  • For example, as a result of the low M2 some embodiments of this invention are capable producing laser light that upon exiting a flat end of a fiber having a diameter of 600 μm has a divergence of 15.3° or lower; 15° or lower; 10° or lower; or 5° or lower, and the power density can be 13,400 watts per cm2, or greater.
  • FIG. 5 shows a block diagram of a preferred laser system according to the present invention. In FIG. 5, a laser resonator is defined by end mirror 10, turning mirrors 12 and 14, and end mirror 16. All of these mirrors are high reflecting (greater than 99.8%) at the 1064 nm line. An optical path 24 is defined by these mirrors. A gain medium 18 comprising a Nd:YAG rod is mounted along the optical path within a pump housing 29. A laser diode array 28D is also mounted within the housing and supplies pump power to the gain medium in response to current generated in power supply 30. Representative laser diodes include laser diodes providing output in the range of 805 to 820 nm in wavelength with an input power to the array of pumping diodes in the range of 300 to 500 Watts. The laser diodes used for pump energy are operated in a modulated macro-pulse mode, or in a continuous mode, as suits a particular implementation.
  • Also in the optical path 24 is a Q-switch 20 between the lamp housing 29 and the turning mirror 12. A non-linear crystal 22 is mounted between the turning mirror 14 and the back mirror 16. This non-linear crystal is preferably a KTP crystal aligned for frequency doubling to generate a 532 nm beam. Mirrors 16 and 14 are highly reflective at 532 nm, while mirror 12 is transmissive and operates as an output coupler for the 532 nm beam.
  • Thus, the laser resonator is designed for resonating at a first frequency, i.e., 1064 nm along the Z-shaped optical path 24. A second frequency derived from the 1064 nm beam is generated in the KTP crystal 22. This beam travels along the path 26 a and is extracted from the resonator to supply an output beam along path 26 b.
  • The output beam along path 26 b passes through a controllable attenuator 36, a beam splitter 38, which supplies a portion of the output beam to a surgical detector 40, and a component group 42 as described in more detail below. The attenuator, detector, and component group are all coupled to a data processing system 34, across lines 34 j, 34 k, and 34 p.
  • The Q-switch 20 is controlled by Q-switch driver 21, which is, in turn, coupled to data processor 34 across line 34 i. In the preferred system, the Q-switch is an acoustic-optic Q-switch.
  • Similarly, the power supply 30 generates an electrical power signal for controlling the diode array 28D. This power signal is controlled by the data processor 34 across line 34 h and by drive circuitry 32 across line 32 a. Drive circuitry 32 a is controlled by the data processor across lines 34 a through 34 g. A sensor 57 is coupled with the data processor to sense an environmental condition, such as temperature or humidity, that affects operation of the laser system. A modem 56 is connected to the data processor 34, providing an interface for remote access to memory in the data processor. Finally, a control panel 35, by which a user can supply input signals and parameters, is provided. This control panel 35 is connected to the data processor 34 across line 34 n.
  • In alternative systems, the non-linear crystal may be mounted outside the resonant cavity of the resonator. Also, it may be used for extracting outputs other than the second harmonic, such as sum-of-frequency derivation or the like.
  • The wavelength used according to the present invention for gynecological conditions treatment should be strongly absorbed in the tissue to help initiate and maintain tissue vaporization without creating deep tissue heating. The wavelength also must be minimally absorbed by the irrigant used during the procedure, typically physiologic saline solution. The 532 nm light produced by the system of FIG. 5, is both strongly absorbed in oxyhemoglobin and weakly absorbed in physiologic saline solution. Oxyhemoglobin is readily present in uterine tissue and serves as an efficient chromophore for 532 nm light. The differential in absorption coefficients between oxyhemoglobin and water at 532 nm is approximately 5 orders of magnitude (105). In other embodiments, wavelengths in the range from 200 nm-650 nm are used, which have strong oxyhemoglobin absorption and relatively weak water absorption (>102×). In yet other embodiments, wavelengths in the range from 200 nm to 650 nm range are used, which have strong oxyhemoglobin absorption and relatively weak water absorption (>10×).
  • Of course, as shown in FIG. 6, in which like components have the same reference numerals as in FIG. 5, alternative pump power sources, such as arc lamps 28, and flash lamps, other lasers for longitudinal pumping, and others, can be used as suits the needs of a particular gain medium and application of the laser system.
  • The laser systems shown in FIGS. 5 and 6 can be modified by removing both the Q-switch and the external surgical attenuator. The Q-switch and surgical attenuator are removed because the modulated pump power provides a great deal of flexibility in controlling the output power of the laser not attainable using a Q-switch. The data processing system can be programmed to maintain a constant thermal load in the laser system while varying the peak pump power widely. Thus, the peak current and duty cycle of the pump power source can be adjusted in such a way to keep the average pump power constant, but the second harmonic power during the ready and work modes adjusted by selecting the peak current and duty cycle. Although it may be necessary to use attenuators in the beamline during the ready mode in order to extract an aim beam, such attenuators may well be eliminated for the work mode. The average power does not have to be constant, rather it can be maintained at levels which keep thermal focusing of the gain medium within the range of stability of the resonator.
  • A representative laser system adapted for delivery of energy as described above, comprises an 80 watt average power, 532 nm output wavelength, solid state, intra-cavity frequency doubled Nd:YAG laser. To obtain optimal efficiency, an arc lamp pump source is modulated at a period of 4.5 ms with a 16 ms duty cycle, generating 285 watts peak macro-pulse power. An intra-cavity acousto-optic AO Q-switch is used to further modulate the energy at a period of 40 kHz with a 450 us micro-pulse. The laser energy is coupled to a side firing fiber optic delivery device for delivery to uterine tissue.
  • The laser system uses a combination touch screen and control knob user interface to assist the operator in setting up the surgical parameters, including power levels and pulse sequence specifications. The average power setting is prominently displayed on the screen. Parameter adjustments are made by first activating (touching) the desired parameter box on the screen and then turning the knob. The laser system uses a secure card key interface to enable the laser. The system is transportable. The system offers convenient storage and a fiber delivery device pole.
  • An example of an endoscope, in particular a hysteroscope, for use with the present invention is shown in FIG. 7. The hysteroscope has a distal end 200 and a proximal end 201. Laser radiation 205 is directed from and end firing fiber through an opening 206, by a fiber optic component. Water, Ringer Lactate or saline solution is delivered and removed from the treatment area via lumens in the probe. A viewing optic is also placed in the opening 206, by which the surgeon is able to view the treatment area during the procedure. On the proximal end 201 of the endoscope, an irrigation port 203 for flow of the irrigant is provided. Also, a fiber port 207 is used for insertion and removal of the fiber optic delivering laser radiation to the treatment area. A light source connector 209 is used for supplying light to the treatment area for visualization. An viewing port 211, which can be coupled to a video camera, or looked into directly, is also included on the representative hysteroscope. The endoscope includes a flexible tip in one embodiment, and controls (not shown) in the near proximal end 201, by which the surgeon deflects and guides the positioning of the tip at distal end 200. Representative systems for providing flexible tip endoscopes are described in U.S. Pat. No. 4,802,461, and are widely used for surgical procedures.
  • The vaporization of uterine tissue using oxyhemoglobin as the primary chromophore is related to the incident power density, or irradiance, which can be expressed in Watts/cm2. The overall rate of uterine tissue vaporization is a function of the spot size, absorption depth, and the power density. A large spot with high power density, and rapid absorption is ideal to rapidly vaporize tissue. A high power light source is required to achieve a large spot, high power density treatment beam. Peak laser power, average laser power, beam quality, delivery device design and delivery device placement all affect the efficiency of vaporization. A treatment beam 28.5 Kw/cm2 average irradiance with a 85.5 Kw/cm2 peak irradiance macro-pulse, with a spot size between about 0.2 and 0.5 mm2, rapidly vaporizes tissue.
  • FIGS. 8 and 9 illustrate the different optical penetration depths of the 532 nm wavelength and 1064 nm wavelength used in prior art procedures. See, S. L. Jacques. Laser-tissue interaction. Photochemical, photothermal, and photomechanical. Surg. Clin N. Am. 1992; 72(3): 531-558. The optical penetration depth of the 1064 wavelength beam from Nd:YAG laser beam is about 10 mm, which is 13 times larger than the penetration depth of the second harmonic 532 wavelength laser beam, which is about 0.8 mm. As a result, the 1064 laser power is spread out over a much larger tissue volume than the power of the KTP laser. In case of the 1064 laser as shown in FIG. 9, the temperature at the tissue surface barely reaches 100° C. Therefore, only a small portion of tissue gets vaporized. But a huge volume of tissue gets coagulated (see space between 100° C. and 60° C. isotherm).
  • The 532 laser beam, in contrast, is substantially completely absorbed within less than about 1 mm of the surface of uterine tissue. The laser power is confined to a very small tissue volume. The high volumetric power density results in a fast heating of the tissue and efficient tissue vaporization. Volumetric power density delivered to tissue is a function of the absorbtion depth, irradiance in Watts/cm2 and spot size on the surface of the tissue. The coagulation zone is very thin because of the small optical penetration depth of the 532 wavelength, and because substantially all of the radiation is converted to vaporization rather than residual heat.
  • Other wavelengths which are substantially completely absorbed within less than about 1 mm of the surface of the uterine tissue include wavelengths between about 200 and 1000 nm, including wavelengths less than about 700 nm, for example between about 200 nm and 650 nm.
  • FIGS. 10 and 11 illustrate a profile of a beam delivered to tissue using one representative side firing optical fiber, to show spot size as a function of distance from the side of the optical fiber. FIG. 10 is an end view, showing a fiber 600, cladding 601 on the fiber, an air space 602, and a tip 603 through which the beam is directed by a reflecting face on the fiber. The cross-section of the beam is represented by the crossing lines 604 and 605. As shown, the beam has a width in this dimension of about 0.35 mm at 1 mm from the side of the tip 603. At about 2 mm from the side of the tip 603, the width is about 1 mm. At about 3 mm distance from the side of the tip 603, the beam width is about 2.2 mm.
  • FIG. 11 is a side view, with like components given the same reference numbers. The beam width in this dimension is represented by lines 606 and 607. As shown, the beam has a width in this dimension of about 0.7 mm at 1 mm from the side of the tip 603. At about 2 mm from the side of the tip 603, the width is about 1 mm. At about 3 mm distance from the side of the tip 603, the beam width is about 1.5 mm.
  • Thus, the spot size at 1 mm from the side of the tip is defined basically by an ellipse having a major axis of 0.7 mm, and a minor axis of 0.35 mm. The area of the spot at 1 mm is around 0.2 mm2. At 2 mm from the side, the area of the spot is about 0.8 mm2.
  • For rapid procedures, according to the present invention, the spot size should be large enough that the operator can remove tissue at a reasonable rate, and see the results of a single pass of the spot over a region of tissue. If the spot size is too small, the rate of the operation is too slow. Also, if the spot size is too big, then the procedure is difficult to control precisely. A preferred spot size is less than about 1 mm2, and more particularly between about 0.8 mm2 and about 0.05 mm2. Other apparatus may be used for delivery of the beam with the desired spot size, including embodiments without diverging beams, and embodiments with converging beams.
  • The irradiance of the beam at 1 mm from the side of the tip for an 80 W average power laser as described above is about 30 kiloWatts/cm2. According to the present invention, it is desirable to provide a wavelength between about 650 and 200 nm, with a spot size on the surface of the tissue less than about 0.8 mm2, and preferably greater than about 0.05 mm2, with an irradiance greater than about 10 kiloWatts/cm2, and more preferably greater than 20 kiloWatts/cm2, and even more preferably 30 kiloWatts/cm2 or higher.
  • FIG. 12 shows, heuristically, how vaporization rate and coagulation rate depend on the volumetric power density. The vaporization rate (in mm/s) is defined as tissue depth that is vaporized per time interval. The coagulation rate (in mm/s) is defined as the depth of residual coagulated tissue that remains after a certain time of vaporization.
  • Below a certain volumetric power density, referred to as a “vaporization threshold” in FIG. 12, no tissue gets vaporized. All laser energy stays inside the tissue. Tissue coagulation occurs where the tissue temperature rises above approximately 60° C. As the volumetric power density is increased a bigger and bigger tissue volume gets coagulated.
  • At the vaporization threshold, vaporization starts. Above the vaporization threshold the vaporization rate can be considered to increase linearly with the volumetric power density for the purpose of understanding the present invention, and as described by a steady state model for continuous wave laser tissue ablation, known by those familiar with the art of laser-tissue interaction.
  • As more and more laser energy is consumed by vaporization of the tissue, the amount of laser energy leading to residual tissue coagulation gets smaller, i.e. the amount of residual coagulation drops. Thus, extent of the zone of thermal damage characterized by tissue coagulation left after the procedure gets smaller with increasing volumetric power density, while the rate of vaporization increases. Substantial and surprising improvement in results is achieved.
  • Publications about visual laser ablation of the prostate (VLAP) that is performed with an Nd:YAG laser at 1064 nm have shown that this type of laser is not able to vaporize a significant amount of tissue. Histology studies have shown that the 1064 nm laser induces deep coagulation in the tissue that results in edema and delayed tissue sloughing. This effect was described by Kuntzman, et al., High-power potassium titanyl phosphate laser vaporization prostatectomy. Mayo Clin Proc 1998: 73: 798-801. Thus, in the heuristic diagram of FIG. 12, the VLAP procedure is believed to lie around point 650, barely above the vaporization threshold. Also, prior art technologies using 532 nm with spot sizes on the order of 1 mm2 with average output power of 60 Watts, are believed to lie, heuristically, around point 651 in the FIG. 12. Kuntzman et al present results for the coagulation depth of a 60 W continuous wave 532 nm laser, with suggested operation at a distance of 2 mm from the side of the tip, yielding less than 5 kiloWatts/cm2 irradiance.
  • As the laser power is further increased to 80 W, and the side firing probe is placed less than 1 mm from the tissue for a small spot size, the ablation rate further increases and the coagulation rate further drops, so that the procedure lies heuristically at point 652 in FIG. 12.
  • A 80 Watt KTP laser can be used to easily reach irradiance levels that vaporize substantially more tissue than is left as residual coagulation after the procedure. More precisely, the vaporization rate is substantially higher than the coagulation rate as given by the definition above, using high irradiance levels that are easily achieved with higher power lasers. Because of higher vascularization in the uterus, the optical penetration depth is lower than in prostatic tissue, and therefore the volumetric power density at the vaporization threshold can be easily reached with lower average power lasers, including for example a 40 W average output power laser.
  • FIG. 13 illustrates a uterus, generally 500, having myomas treatable according to the present invention, including intracavitery protruding myomas 501, 502, intracavitery pedunculated myoma 503, and intramural, submucosal myoma 540. Myoma 502 is located in the right cornu. Hysteroscope 505 is positioned through the cervix 506 with a flexible tip 507 adjacent myoma 502, and delivering laser radiation as described above.
  • FIG. 14 illustrates use of a side firing probe 509 for treatment of a myoma 510 located in one of the uterine cornua. FIG. 15 illustrates use of an end firing probe 511, for treatment of a myoma 512 located in one of the uterine cornua.
  • While the invention has been particularly shown and described with reference to preferred embodiments thereof, it will be understood by those skilled in the art, that various changes in form and details may be made therein without departing from the spirit and scope of the invention, as defined by the appended claims.

Claims (26)

1. An apparatus for photoselective vaporization of tissue of a female reproductive organ, comprising:
a laser producing laser radiation;
a hysteroscope, including an optical fiber coupled to the laser, adapted to direct laser radiation from the fiber, and a flow of irrigant to a treatment area on a surface of the tissue;
said optical fiber being adapted to deliver the laser radiation at a wavelength and irradiance in the treatment area sufficient to cause vaporization of a substantially greater volume of tissue than a volume of residual coagulated tissue caused by the laser radiation.
2. The apparatus of claim 1, wherein the laser comprises a Neodymium doped solid state laser medium, and optics producing a second or higher harmonic output with greater than 40 Watts average output power.
3. The apparatus of claim 1, wherein the laser comprises a Neodymium doped solid state laser medium, and optics producing a second or higher harmonic output with greater than 60 Watts average output power.
4. The apparatus of claim 1, wherein the laser and optical fiber are adapted to deliver laser radiation having a wavelength in a range of about 200 nm to about 700 nm, and has an average irradiance in the treatment area greater than 10 kiloWatts/cm2 and the optical fiber is adapted to cause a spot size of at least about 0.05 mm2 in the treatment area.
5. The apparatus of claim 1, wherein the laser and optical fiber are adapted to deliver laser radiation having a wavelength in a range of about 200 nm to about 700 nm, and has an average irradiance in the treatment area greater than 20 kiloWatts/cm2 and the optical fiber is adapted to cause a spot size of at least about 0.05 mm2 in the treatment area.
6. The apparatus of claim 1, wherein the laser and optical fiber are adapted to deliver laser radiation having a wavelength in a range of about 200 m to about 700 nm, and has an average irradiance in the treatment area greater than 30 kiloWatts/cm2 and the optical fiber is adapted to cause a spot size of at least about 0.05 mm2 in the treatment area.
7. The apparatus of claim 1, wherein the laser and optical fiber are adapted to deliver laser radiation having a wavelength in a range of about 200 nm to about 700 nm, and has an average irradiance in the treatment area greater than 10 kiloWatts/cm2, and the optical fiber is adapted to cause a spot size is less than about 0.8 mm2 in the treatment area.
8. The apparatus of claim 1, wherein the laser and optical fiber are adapted to deliver average irradiance of at least 30 kiloWatts/cm2 in the treatment area.
9. The apparatus of claim 1, wherein the optical fiber includes a side firing tip, and is further adapted for placement of said side firing tip within about 1 mm, or less, of the treatment area.
10. The apparatus of claim 1, wherein the optical fiber includes an end firing tip, and is further adapted for placement of said end firing tip within about 1 mm, or less, of the treatment area.
11. The apparatus of claim 1, wherein the laser includes a Q-switch to produce micro-pulses during application of input power to the laser medium, and a power source applying input power to the laser medium in a sequence of pulses to generate macro-pulses of output radiation, and wherein said output power is greater than about 200 Watts during said macro-pulses.
12. The apparatus of claim 1, wherein the laser includes a Q-switch to produce micro-pulses during application of input power to the laser medium, and a power source applying input power to the laser medium a sequence of pulses to generate macro-pulses of output radiation, and said irradiance is greater than 50 kiloWatts/cm2 during the macro-pulse.
13. The method of claim 1, wherein the laser radiation has a beam quality (M2) that is less than or equal to 100.
14. The apparatus of claim 1, including a control system coupled to the laser, and controlling output of the laser so that the laser radiation has characteristics suitable to cause a treatment of uterine tissue, and said treatment is for a gynecological condition selected from leiomyoma uteri, rhabdomyoma, endometriosis, endometrial hyperplasia, endometrial cysts, endometrial polyps, menorrhagia, uterine septa, intrauterine adhesions, or cervical intraepithelial neoplasia.
15. An apparatus for photoselective vaporization of tissue of a female reproductive organ, comprising:
a laser producing laser radiation having a wavelength in a range from about 200 nm to about 700 nm;
an endoscope, including an optical fiber coupled to the laser, adapted to direct laser radiation from the fiber, and a flow of irrigant to a treatment area on a surface of the tissue;
the laser and optical fiber being adapted to deliver the laser radiation with an average irradiance in the treatment area greater than 10 kiloWatts/cm2 and the optical fiber is adapted to cause a spot size of at least about 0.05 mm2 in the treatment area.
16. The apparatus of claim 15, wherein the laser comprises a Neodymium doped solid state laser medium, and optics producing a second or higher harmonic output with greater than 40 Watts average output power.
17. The apparatus of claim 15, wherein the laser comprises a Neodymium doped solid state laser medium, and optics producing a second or higher harmonic output with greater than 60 Watts average output power.
18. The apparatus of claim 15, wherein the laser and optical fiber are adapted to deliver laser radiation having an average irradiance in the treatment area greater than 20 kiloWatts/cm2.
19. The apparatus of claim 15, wherein the laser and optical fiber are adapted to deliver laser radiation having an average irradiance in the treatment area greater than 30 kiloWatts/cm2.
20. The apparatus of claim 15, wherein the laser and optical fiber are adapted to deliver laser radiation having a spot size is less than about 0.8 mm2 in the treatment area.
21. The apparatus of claim 15, wherein the optical fiber includes a side firing tip, and is further adapted for placement of said side firing tip within about 1 mm, or less, of the treatment area.
22. The apparatus of claim 15, wherein the optical fiber includes an end firing tip, and is further adapted for placement of said end firing tip within about 1 mm, or less, of the treatment area.
23. The apparatus of claim 15, wherein the laser includes a Q-switch to produce micro-pulses during application of input power to the laser medium, and a power source applying input power to the laser medium in a sequence of pulses to generate macro-pulses of output radiation, and wherein said output power is greater than about 200 Watts during said macro-pulses.
24. The apparatus of claim 15, wherein the laser includes a Q-switch to produce micro-pulses during application of input power to the laser medium, and a power source applying input power to the laser medium a sequence of pulses to generate macro-pulses of output radiation, and said irradiance is greater than 50 kiloWatts/cm2 during the macro-pulse.
25. The apparatus of claim 15, wherein the laser radiation has a beam quality (M2) that is less than or equal to 100.
26. The apparatus of claim 15, including a control system coupled to the laser, and controlling output of the laser so that the laser radiation has characteristics suitable to cause a treatment of uterine tissue, and said treatment is for a gynecological condition selected from leiomyoma uteri, rhabdomyoma, endometriosis, endometrial hyperplasia, endometrial cysts, endometrial polyps, menorrhagia, uterine septa, intrauterine adhesions, or cervical intraepithelial neoplasia.
US11/099,040 2002-02-22 2005-04-05 Method and system for photoselective vaporization for gynecological treatments Abandoned US20050177145A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
US11/099,040 US20050177145A1 (en) 2002-02-22 2005-04-05 Method and system for photoselective vaporization for gynecological treatments

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US35835602P 2002-02-22 2002-02-22
US10/371,080 US7063694B2 (en) 2002-02-22 2003-02-21 Method and system for photoselective vaporization for gynecological treatments
US11/099,040 US20050177145A1 (en) 2002-02-22 2005-04-05 Method and system for photoselective vaporization for gynecological treatments

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
US10/371,080 Division US7063694B2 (en) 2002-02-22 2003-02-21 Method and system for photoselective vaporization for gynecological treatments

Publications (1)

Publication Number Publication Date
US20050177145A1 true US20050177145A1 (en) 2005-08-11

Family

ID=27765954

Family Applications (3)

Application Number Title Priority Date Filing Date
US10/371,080 Expired - Lifetime US7063694B2 (en) 2002-02-22 2003-02-21 Method and system for photoselective vaporization for gynecological treatments
US11/099,040 Abandoned US20050177145A1 (en) 2002-02-22 2005-04-05 Method and system for photoselective vaporization for gynecological treatments
US11/113,495 Abandoned US20050197656A1 (en) 2002-02-22 2005-04-25 Method and system for photoselective vaporization for gynecological treatments

Family Applications Before (1)

Application Number Title Priority Date Filing Date
US10/371,080 Expired - Lifetime US7063694B2 (en) 2002-02-22 2003-02-21 Method and system for photoselective vaporization for gynecological treatments

Family Applications After (1)

Application Number Title Priority Date Filing Date
US11/113,495 Abandoned US20050197656A1 (en) 2002-02-22 2005-04-25 Method and system for photoselective vaporization for gynecological treatments

Country Status (7)

Country Link
US (3) US7063694B2 (en)
EP (1) EP1485036B1 (en)
JP (1) JP2005518255A (en)
AT (1) ATE485785T1 (en)
AU (1) AU2003222234A1 (en)
DE (1) DE60334683D1 (en)
WO (1) WO2003072189A2 (en)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070270788A1 (en) * 2006-05-19 2007-11-22 Ams Research Corporation Endoscope and optical fiber assembly
WO2007092805A3 (en) * 2006-02-07 2008-01-24 Ams Res Corp Laparoscopic laser device and method
US20080076966A1 (en) * 2006-09-11 2008-03-27 Isaacson Keith B System And Method For A Hysteroscope With Integrated Instruments
EP3023074A1 (en) * 2014-11-22 2016-05-25 Syneron Candela Corporation Laser system for skin treatment

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101083936B (en) * 2004-12-20 2010-06-23 皇家飞利浦电子股份有限公司 Investigation of body structures
US20090043295A1 (en) * 2005-06-06 2009-02-12 Ams Research Corporation Fibroid Treatment Methods and Devices
US7909817B2 (en) 2005-06-08 2011-03-22 Innovaquartz, Inc. (AMS Research Corporation) Lateral laser fiber for high average power and peak pulse energy
US20080009844A1 (en) * 2006-06-26 2008-01-10 Ingeborg Rolle Device for Laser Surgery
US20080154344A1 (en) * 2006-12-22 2008-06-26 Trusty Robert M System and method for treating benign prostatic hyperplasia
US9474576B2 (en) * 2007-10-05 2016-10-25 The Research Foundation For The State University Of New York Coherent imaging fiber based hair removal device
WO2009063083A1 (en) * 2007-11-14 2009-05-22 Renewave Medical System Sa. Effect of radiofrequency fields on cell growth and methods for laparoscopic treatment
AU2010229776B2 (en) 2009-03-27 2013-08-01 Ams Research Corporation Laser modulation for coagulation
PL2459092T3 (en) * 2009-07-27 2020-05-18 Novoxel Ltd. Device for tissue vaporization
US8790382B2 (en) 2009-08-04 2014-07-29 Yonatan Gerlitz Handheld low-level laser therapy apparatus
US9553422B2 (en) 2009-08-04 2017-01-24 Medical Coherence Llc Multiple aperture hand-held laser therapy apparatus
RU2009141140A (en) * 2009-11-09 2011-05-20 Олег Викторович Кузьмин (RU) SURGICAL LASER SYSTEM
US8672929B2 (en) 2010-12-15 2014-03-18 Ams Research Corporation Laser probe tip
US10716624B2 (en) * 2011-05-05 2020-07-21 Biolitec Unternehmensbeteiligungs Ii Ag Minimally invasive contraception method and device
US9946082B2 (en) 2013-04-30 2018-04-17 Medical Coherence Llc Handheld, low-level laser apparatuses and methods for low-level laser beam production
US10335233B2 (en) * 2013-06-28 2019-07-02 Biolitec Unternehmensbeteilligungs Ii Ag Myoma/polyp in-office treatment with lasers
ES2875967T3 (en) 2013-12-18 2021-11-11 Novoxel Ltd Devices for tissue vaporization
PL3193761T3 (en) 2014-09-15 2021-10-18 Novoxel Ltd. Methods for manufacturing devices for thermal tissue vaporization and compression
EP3023073B1 (en) * 2014-11-24 2021-01-27 Fotona d.o.o. Laser system for tissue ablation
US9220563B1 (en) 2014-12-29 2015-12-29 InnovaQuartz LLC Multiwavelength surgical laser
US11911101B2 (en) * 2016-02-03 2024-02-27 Cyclone Biosciences, Llc Process and system for reducing laser damage to surgical instruments
US11272983B2 (en) * 2016-02-03 2022-03-15 Cyclone Biosciences, Llc Process and system for reducing laser damage to surgical instruments
US10639102B2 (en) * 2018-05-03 2020-05-05 InnovaQuartz LLC Maintenance of a steam bubble during surgical ablation
CN110507284B (en) * 2019-07-29 2021-10-08 华南师范大学 Photo-thermal optical coherence tomography method and system
CN113545843B (en) * 2021-07-20 2023-09-26 广东迪光医学科技有限公司 Laser ablation system and method

Citations (59)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4383318A (en) * 1980-12-15 1983-05-10 Hughes Aircraft Company Laser pumping system
US4402569A (en) * 1980-05-31 1983-09-06 Barr & Stroud Limited Optical fibre light guides for use with lasers
US4418689A (en) * 1980-09-22 1983-12-06 Olympus Optical Co., Ltd. Laser device for an endoscope
US4646737A (en) * 1983-06-13 1987-03-03 Laserscope, Inc. Localized heat applying medical device
US4722337A (en) * 1983-08-22 1988-02-02 Laserscope Medical laser peripherals and connector system
US4784135A (en) * 1982-12-09 1988-11-15 International Business Machines Corporation Far ultraviolet surgical and dental procedures
US4862886A (en) * 1985-05-08 1989-09-05 Summit Technology Inc. Laser angioplasty
US4907235A (en) * 1988-04-01 1990-03-06 Laserscope Intra-cavity beam relay for optical harmonic generation
US4944738A (en) * 1987-10-13 1990-07-31 Rodriguez Michael A Surgical laser backstop instrument
US4981138A (en) * 1988-06-30 1991-01-01 Yale University Endoscopic fiberoptic fluorescence spectrometer
US5025446A (en) * 1988-04-01 1991-06-18 Laserscope Intra-cavity beam relay for optical harmonic generation
US5066291A (en) * 1990-04-25 1991-11-19 Cincinnati Sub-Zero Products, Inc. Solid-state laser frequency conversion system
US5071422A (en) * 1985-04-24 1991-12-10 Candela Laser Corporation Use of lasers to break down objects
US5151909A (en) * 1990-10-16 1992-09-29 Laserscope Frequency doubled solid state laser having programmable pump power modes and method for controllable lasers
US5231641A (en) * 1992-01-21 1993-07-27 Laserscope Crystalline slab laser with intracavity non-linear optic
US5243615A (en) * 1991-11-20 1993-09-07 Laserscope High-powered intracavity non-linear optic laser
US5242437A (en) * 1988-06-10 1993-09-07 Trimedyne Laser Systems, Inc. Medical device applying localized high intensity light and heat, particularly for destruction of the endometrium
US5249192A (en) * 1991-06-27 1993-09-28 Laserscope Multiple frequency medical laser
US5257991A (en) * 1990-11-15 1993-11-02 Laserscope Instrumentation for directing light at an angle
US5269779A (en) * 1988-06-06 1993-12-14 Sumitomo Electric Industries, Ltd. Laser beam guiding fiber assembly
US5300061A (en) * 1991-08-29 1994-04-05 Surgical Technologies, Inc. Laser delivery probe having a mechanically free floating sheath
US5312396A (en) * 1990-09-06 1994-05-17 Massachusetts Institute Of Technology Pulsed laser system for the surgical removal of tissue
US5312392A (en) * 1992-08-31 1994-05-17 Messerschmitt-Boelkow-Blohm Ag Interstitial laser coagulation treatment for benign prostatic hyperplasia
US5354294A (en) * 1993-05-26 1994-10-11 Xintec Corporation Combination reflectance fiber optic laser beam angle delivery
US5409481A (en) * 1992-05-21 1995-04-25 Laserscope Laser tissue welding control system
US5409483A (en) * 1993-01-22 1995-04-25 Jeffrey H. Reese Direct visualization surgical probe
US5451221A (en) * 1993-12-27 1995-09-19 Cynosure, Inc. Endoscopic light delivery system
US5487740A (en) * 1994-03-02 1996-01-30 Energy Life Systems Corporation Laser device for ablation of human tissue
US5495541A (en) * 1994-04-19 1996-02-27 Murray; Steven C. Optical delivery device with high numerical aperture curved waveguide
US5520679A (en) * 1992-12-03 1996-05-28 Lasersight, Inc. Ophthalmic surgery method using non-contact scanning laser
US5542944A (en) * 1993-04-19 1996-08-06 Bhatta; Krishan M. Surgical device and method
US5599349A (en) * 1994-09-30 1997-02-04 Circon Corporation V shaped grooved roller electrode for a resectoscope
US5607420A (en) * 1992-02-25 1997-03-04 Surgical Laser Technologies, Inc. Surgical tool for use with a contact laser
US5628744A (en) * 1993-12-21 1997-05-13 Laserscope Treatment beam handpiece
US5632739A (en) * 1994-10-13 1997-05-27 The General Hospital Corporation Two-pulse, lateral tissue illuminator
US5662646A (en) * 1992-11-04 1997-09-02 Fumich; Robert Mark Method and apparatus for laser surgery
US5700260A (en) * 1994-05-13 1997-12-23 Cynosure, Inc. Endoscopic light delivery system
US5733279A (en) * 1994-12-21 1998-03-31 Laser Industries, Ltd. Device for treating the interior of body cavities with laser energy
US5746760A (en) * 1995-01-17 1998-05-05 Laserscope Semi-automatic tissue morcellation device
US5772658A (en) * 1994-12-20 1998-06-30 Laser Industries, Ltd. Side-emitting optical fibers for lasers
US5776175A (en) * 1995-09-29 1998-07-07 Esc Medical Systems Ltd. Method and apparatus for treatment of cancer using pulsed electromagnetic radiation
US5778395A (en) * 1995-10-23 1998-07-07 Stac, Inc. System for backing up files from disk volumes on multiple nodes of a computer network
US5798518A (en) * 1995-07-28 1998-08-25 Laserscope Medical laser calibration system and method
US5832013A (en) * 1992-09-25 1998-11-03 American Dental Technologies, Inc. Intracavity modulated pulsed laser and methods of using the same
US5841800A (en) * 1995-07-28 1998-11-24 Laserscope Desktop medical laser generator
US5843026A (en) * 1992-08-12 1998-12-01 Vidamed, Inc. BPH ablation method and apparatus
US6024751A (en) * 1997-04-11 2000-02-15 Coherent Inc. Method and apparatus for transurethral resection of the prostate
US6033400A (en) * 1996-04-19 2000-03-07 Circon Corporation Shaped electrode for a resectoscope
US6064914A (en) * 1998-04-01 2000-05-16 Trachtenberg; John R. Thermotherapy method
US6156030A (en) * 1997-06-04 2000-12-05 Y-Beam Technologies, Inc. Method and apparatus for high precision variable rate material removal and modification
US6197025B1 (en) * 1994-09-30 2001-03-06 Circon Corporation Grooved slider electrode for a resectoscope
US6282442B1 (en) * 1998-09-11 2001-08-28 Surgical Laser Technologies, Inc. Multi-fit suction irrigation hand piece
US6389313B1 (en) * 1999-03-26 2002-05-14 Kevin S. Marchitto Laser probes for drug permeation
US6423055B1 (en) * 1999-07-14 2002-07-23 Cardiofocus, Inc. Phototherapeutic wave guide apparatus
US20020193850A1 (en) * 1993-09-29 2002-12-19 Selman Steven H. Use of photodynamic therapy to treat prostatic tissue
US6530921B1 (en) * 1999-07-30 2003-03-11 Terumo Kabushiki Kaisha Laser irradiation apparatus
US6554824B2 (en) * 2000-12-15 2003-04-29 Laserscope Methods for laser treatment of soft tissue
US6596017B1 (en) * 1998-09-10 2003-07-22 Prostalund Operations Ab Device for heat treatment of body tissue
US6699239B1 (en) * 1998-05-18 2004-03-02 Dornier Medtech Systems Gmbh Laser instrument

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4648892A (en) * 1985-03-22 1987-03-10 Massachusetts Institute Of Technology Method for making optical shield for a laser catheter
US4760840A (en) * 1986-12-16 1988-08-02 The Regents Of The University Of California Endoscopic laser instrument
US4834091A (en) 1987-04-10 1989-05-30 Ott Douglas E Intrauterine fallopian tube ostial plug and surgical process
US4802461A (en) 1987-08-26 1989-02-07 Candela Laser Corporation Rigid endoscope with flexible tip
US4836189A (en) 1988-07-27 1989-06-06 Welch Allyn, Inc. Video hysteroscope
US5147353A (en) * 1990-03-23 1992-09-15 Myriadlase, Inc. Medical method for applying high energy light and heat for gynecological sterilization procedures
US5897551A (en) * 1990-03-23 1999-04-27 Myriadlase, Inc. Medical device for applying high energy light and heat for gynecological sterilization procedures
US5242390A (en) * 1991-05-03 1993-09-07 Goldrath Milton H Endometrium coagulating surgical method for thermal destruction of the endometrium
US5370649A (en) 1991-08-16 1994-12-06 Myriadlase, Inc. Laterally reflecting tip for laser transmitting fiber
US5437660A (en) 1991-12-30 1995-08-01 Trimedyne, Inc. Tissue ablation and a lateral-lasing fiber optic device therefor
US5269430A (en) * 1992-01-28 1993-12-14 Packaging Corporation Of America Individual serving food container with improved housing and closure arrangement
US5421323A (en) * 1992-12-02 1995-06-06 Richard Wolf Gmbh Endoscope with additional viewing aperture
IL104100A (en) * 1992-12-15 1997-11-20 Laser Ind Ltd Device for treating the interior of body cavities with laser energy
USD352423S (en) * 1993-03-30 1994-11-15 Dart Industries Inc. Microwave reheatable container
US5428699A (en) * 1993-07-02 1995-06-27 Laserscope Probe having optical fiber for laterally directing laser beam
US5377860A (en) * 1993-09-14 1995-01-03 James River Corporation Of Virginia Double seal food container
US5897001A (en) * 1995-09-19 1999-04-27 Dembicks; Andrew E. Locking holder for interchangeable bit members with accessory display unit
US5772070A (en) * 1996-09-24 1998-06-30 Tenneco Packaging High-strength gusseted lid for a food container
FR2756741B1 (en) * 1996-12-05 1999-01-08 Cird Galderma USE OF A CHROMOPHORE IN A COMPOSITION INTENDED TO BE APPLIED TO THE SKIN BEFORE LASER TREATMENT
USD411714S (en) * 1998-06-24 1999-06-29 S. C. Johnson Home Storage, Inc. Round container with lid
US6032827A (en) * 1998-06-25 2000-03-07 S. C. Johnson Home Storage, Inc. Container having a selectively detachable lid including a rigid tab member
US6112747A (en) * 1998-11-06 2000-09-05 Jones; Jesse M. Method of sterilizing females
US6554825B1 (en) * 2000-05-09 2003-04-29 Laserscope Variable pulse duration, adjustable wavelength medical laser system

Patent Citations (60)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4402569A (en) * 1980-05-31 1983-09-06 Barr & Stroud Limited Optical fibre light guides for use with lasers
US4418689A (en) * 1980-09-22 1983-12-06 Olympus Optical Co., Ltd. Laser device for an endoscope
US4383318A (en) * 1980-12-15 1983-05-10 Hughes Aircraft Company Laser pumping system
US4784135A (en) * 1982-12-09 1988-11-15 International Business Machines Corporation Far ultraviolet surgical and dental procedures
US4646737A (en) * 1983-06-13 1987-03-03 Laserscope, Inc. Localized heat applying medical device
US4722337A (en) * 1983-08-22 1988-02-02 Laserscope Medical laser peripherals and connector system
US5071422A (en) * 1985-04-24 1991-12-10 Candela Laser Corporation Use of lasers to break down objects
US4862886A (en) * 1985-05-08 1989-09-05 Summit Technology Inc. Laser angioplasty
US4944738A (en) * 1987-10-13 1990-07-31 Rodriguez Michael A Surgical laser backstop instrument
US4907235A (en) * 1988-04-01 1990-03-06 Laserscope Intra-cavity beam relay for optical harmonic generation
US5025446A (en) * 1988-04-01 1991-06-18 Laserscope Intra-cavity beam relay for optical harmonic generation
US5269779A (en) * 1988-06-06 1993-12-14 Sumitomo Electric Industries, Ltd. Laser beam guiding fiber assembly
US5242437A (en) * 1988-06-10 1993-09-07 Trimedyne Laser Systems, Inc. Medical device applying localized high intensity light and heat, particularly for destruction of the endometrium
US4981138A (en) * 1988-06-30 1991-01-01 Yale University Endoscopic fiberoptic fluorescence spectrometer
US5066291A (en) * 1990-04-25 1991-11-19 Cincinnati Sub-Zero Products, Inc. Solid-state laser frequency conversion system
US5312396A (en) * 1990-09-06 1994-05-17 Massachusetts Institute Of Technology Pulsed laser system for the surgical removal of tissue
US5151909A (en) * 1990-10-16 1992-09-29 Laserscope Frequency doubled solid state laser having programmable pump power modes and method for controllable lasers
US5257991A (en) * 1990-11-15 1993-11-02 Laserscope Instrumentation for directing light at an angle
US5249192A (en) * 1991-06-27 1993-09-28 Laserscope Multiple frequency medical laser
US5300061A (en) * 1991-08-29 1994-04-05 Surgical Technologies, Inc. Laser delivery probe having a mechanically free floating sheath
US5243615A (en) * 1991-11-20 1993-09-07 Laserscope High-powered intracavity non-linear optic laser
US5231641A (en) * 1992-01-21 1993-07-27 Laserscope Crystalline slab laser with intracavity non-linear optic
US5607420A (en) * 1992-02-25 1997-03-04 Surgical Laser Technologies, Inc. Surgical tool for use with a contact laser
US5409481A (en) * 1992-05-21 1995-04-25 Laserscope Laser tissue welding control system
US5843026A (en) * 1992-08-12 1998-12-01 Vidamed, Inc. BPH ablation method and apparatus
US5312392A (en) * 1992-08-31 1994-05-17 Messerschmitt-Boelkow-Blohm Ag Interstitial laser coagulation treatment for benign prostatic hyperplasia
US5832013A (en) * 1992-09-25 1998-11-03 American Dental Technologies, Inc. Intracavity modulated pulsed laser and methods of using the same
US5662646A (en) * 1992-11-04 1997-09-02 Fumich; Robert Mark Method and apparatus for laser surgery
US5520679A (en) * 1992-12-03 1996-05-28 Lasersight, Inc. Ophthalmic surgery method using non-contact scanning laser
US5409483A (en) * 1993-01-22 1995-04-25 Jeffrey H. Reese Direct visualization surgical probe
US5542944A (en) * 1993-04-19 1996-08-06 Bhatta; Krishan M. Surgical device and method
US5354294A (en) * 1993-05-26 1994-10-11 Xintec Corporation Combination reflectance fiber optic laser beam angle delivery
US20020193850A1 (en) * 1993-09-29 2002-12-19 Selman Steven H. Use of photodynamic therapy to treat prostatic tissue
US5628744A (en) * 1993-12-21 1997-05-13 Laserscope Treatment beam handpiece
US5451221A (en) * 1993-12-27 1995-09-19 Cynosure, Inc. Endoscopic light delivery system
US5487740A (en) * 1994-03-02 1996-01-30 Energy Life Systems Corporation Laser device for ablation of human tissue
US5495541A (en) * 1994-04-19 1996-02-27 Murray; Steven C. Optical delivery device with high numerical aperture curved waveguide
US5700260A (en) * 1994-05-13 1997-12-23 Cynosure, Inc. Endoscopic light delivery system
US6197025B1 (en) * 1994-09-30 2001-03-06 Circon Corporation Grooved slider electrode for a resectoscope
US5599349A (en) * 1994-09-30 1997-02-04 Circon Corporation V shaped grooved roller electrode for a resectoscope
US5632739A (en) * 1994-10-13 1997-05-27 The General Hospital Corporation Two-pulse, lateral tissue illuminator
US5776127A (en) * 1994-10-13 1998-07-07 The General Hospital Corporation Two-pulse, lateral tissue illuminator
US5772658A (en) * 1994-12-20 1998-06-30 Laser Industries, Ltd. Side-emitting optical fibers for lasers
US5733279A (en) * 1994-12-21 1998-03-31 Laser Industries, Ltd. Device for treating the interior of body cavities with laser energy
US5746760A (en) * 1995-01-17 1998-05-05 Laserscope Semi-automatic tissue morcellation device
US5841800A (en) * 1995-07-28 1998-11-24 Laserscope Desktop medical laser generator
US5798518A (en) * 1995-07-28 1998-08-25 Laserscope Medical laser calibration system and method
US5776175A (en) * 1995-09-29 1998-07-07 Esc Medical Systems Ltd. Method and apparatus for treatment of cancer using pulsed electromagnetic radiation
US5778395A (en) * 1995-10-23 1998-07-07 Stac, Inc. System for backing up files from disk volumes on multiple nodes of a computer network
US6033400A (en) * 1996-04-19 2000-03-07 Circon Corporation Shaped electrode for a resectoscope
US6024751A (en) * 1997-04-11 2000-02-15 Coherent Inc. Method and apparatus for transurethral resection of the prostate
US6156030A (en) * 1997-06-04 2000-12-05 Y-Beam Technologies, Inc. Method and apparatus for high precision variable rate material removal and modification
US6064914A (en) * 1998-04-01 2000-05-16 Trachtenberg; John R. Thermotherapy method
US6699239B1 (en) * 1998-05-18 2004-03-02 Dornier Medtech Systems Gmbh Laser instrument
US6596017B1 (en) * 1998-09-10 2003-07-22 Prostalund Operations Ab Device for heat treatment of body tissue
US6282442B1 (en) * 1998-09-11 2001-08-28 Surgical Laser Technologies, Inc. Multi-fit suction irrigation hand piece
US6389313B1 (en) * 1999-03-26 2002-05-14 Kevin S. Marchitto Laser probes for drug permeation
US6423055B1 (en) * 1999-07-14 2002-07-23 Cardiofocus, Inc. Phototherapeutic wave guide apparatus
US6530921B1 (en) * 1999-07-30 2003-03-11 Terumo Kabushiki Kaisha Laser irradiation apparatus
US6554824B2 (en) * 2000-12-15 2003-04-29 Laserscope Methods for laser treatment of soft tissue

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007092805A3 (en) * 2006-02-07 2008-01-24 Ams Res Corp Laparoscopic laser device and method
AU2007212089B2 (en) * 2006-02-07 2010-04-22 Ams Research Corporation Laparoscopic laser device and method
US20070270788A1 (en) * 2006-05-19 2007-11-22 Ams Research Corporation Endoscope and optical fiber assembly
US9277853B2 (en) 2006-05-19 2016-03-08 Ams Research, Llc Endoscope and optical fiber assembly
US20080076966A1 (en) * 2006-09-11 2008-03-27 Isaacson Keith B System And Method For A Hysteroscope With Integrated Instruments
US8678999B2 (en) 2006-09-11 2014-03-25 Karl Storz Endovision, Inc. System and method for a hysteroscope with integrated instruments
EP3023074A1 (en) * 2014-11-22 2016-05-25 Syneron Candela Corporation Laser system for skin treatment

Also Published As

Publication number Publication date
DE60334683D1 (en) 2010-12-09
AU2003222234A8 (en) 2003-09-09
US7063694B2 (en) 2006-06-20
WO2003072189A2 (en) 2003-09-04
EP1485036A2 (en) 2004-12-15
US20050197656A1 (en) 2005-09-08
US20030216717A1 (en) 2003-11-20
ATE485785T1 (en) 2010-11-15
EP1485036B1 (en) 2010-10-27
JP2005518255A (en) 2005-06-23
EP1485036A4 (en) 2006-04-12
AU2003222234A1 (en) 2003-09-09
WO2003072189A3 (en) 2003-12-31

Similar Documents

Publication Publication Date Title
US7063694B2 (en) Method and system for photoselective vaporization for gynecological treatments
US10653482B2 (en) System for vaporization of tissue
EP1349509B1 (en) Laser treatment of soft tissue
US20050256513A1 (en) Method and system for vaporization of tissue using direct visualization
US5754573A (en) Method and apparatus for treating vascular lesions
US8137340B2 (en) Apparatus and method for soft tissue ablation employing high power diode-pumped laser
US9844410B2 (en) Flash vaporization surgical systems
US5632739A (en) Two-pulse, lateral tissue illuminator
US6554825B1 (en) Variable pulse duration, adjustable wavelength medical laser system
US20080086118A1 (en) Apparatus and method for diode-pumped laser ablation of soft tissue
Absten Physics of light and lasers
RU2315582C1 (en) Laser assembly
WO2010059734A1 (en) Dynamic laser pulse systems and methods
Goebel Fundamentals of laser science
Auth Laser photocoagulation principles
Colt Basic principles of medical lasers

Legal Events

Date Code Title Description
AS Assignment

Owner name: CIT HEALTHCARE LLC, NEW YORK

Free format text: SECURITY AGREEMENT;ASSIGNOR:LASERSCOPE;REEL/FRAME:018132/0682

Effective date: 20060720

AS Assignment

Owner name: LASERSCOPE, MINNESOTA

Free format text: RELEASE BY SECURED PARTY;ASSIGNOR:CIT HEALTHCARE LLC;REEL/FRAME:026142/0093

Effective date: 20110412

AS Assignment

Owner name: MORGAN STANLEY SENIOR FUNDING, INC., AS ADMINISTRA

Free format text: SECURITY AGREEMENT;ASSIGNOR:LASERSCOPE;REEL/FRAME:026628/0340

Effective date: 20110617

STCB Information on status: application discontinuation

Free format text: ABANDONED -- FAILURE TO RESPOND TO AN OFFICE ACTION

AS Assignment

Owner name: AMS RESEARCH CORPORATION, MINNESOTA

Free format text: RELEASE OF PATENT SECURITY INTEREST;ASSIGNOR:MORGAN STANLEY SENIOR FUNDING, INC., AS ADMINISTRATIVE AGENT;REEL/FRAME:032380/0053

Effective date: 20140228

Owner name: LASERSCOPE, CALIFORNIA

Free format text: RELEASE OF PATENT SECURITY INTEREST;ASSIGNOR:MORGAN STANLEY SENIOR FUNDING, INC., AS ADMINISTRATIVE AGENT;REEL/FRAME:032380/0324

Effective date: 20140228