US20040193179A1 - Balloon catheter lumen based stent delivery systems - Google Patents

Balloon catheter lumen based stent delivery systems Download PDF

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Publication number
US20040193179A1
US20040193179A1 US10/746,455 US74645503A US2004193179A1 US 20040193179 A1 US20040193179 A1 US 20040193179A1 US 74645503 A US74645503 A US 74645503A US 2004193179 A1 US2004193179 A1 US 2004193179A1
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United States
Prior art keywords
implant
guide member
delivery guide
delivery
release
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
US10/746,455
Inventor
Julian Nikolchev
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Biosensors International Group Ltd
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Cardiomind Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cardiomind Inc filed Critical Cardiomind Inc
Priority to US10/746,455 priority Critical patent/US20040193179A1/en
Priority to DE602004027122T priority patent/DE602004027122D1/en
Priority to JP2006507500A priority patent/JP2006521161A/en
Priority to CA002517823A priority patent/CA2517823A1/en
Priority to PCT/US2004/008909 priority patent/WO2004087006A2/en
Priority to US10/550,707 priority patent/US7785361B2/en
Priority to AT04758233T priority patent/ATE467402T1/en
Priority to EP10004501A priority patent/EP2226040A1/en
Priority to AU2004226464A priority patent/AU2004226464A1/en
Priority to EP04758233A priority patent/EP1608299B1/en
Assigned to CARDIOMIND, INC. reassignment CARDIOMIND, INC. ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: NIKOLCHEV, JULIAN
Publication of US20040193179A1 publication Critical patent/US20040193179A1/en
Priority to US11/266,587 priority patent/US7771463B2/en
Assigned to BIOSENSORS INTERNATIONAL GROUP, LTD. reassignment BIOSENSORS INTERNATIONAL GROUP, LTD. ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: CARDIOMIND, INC.
Abandoned legal-status Critical Current

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/12Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
    • A61B17/12022Occluding by internal devices, e.g. balloons or releasable wires
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/12Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
    • A61B17/12022Occluding by internal devices, e.g. balloons or releasable wires
    • A61B17/12099Occluding by internal devices, e.g. balloons or releasable wires characterised by the location of the occluder
    • A61B17/12109Occluding by internal devices, e.g. balloons or releasable wires characterised by the location of the occluder in a blood vessel
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/12Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
    • A61B17/12022Occluding by internal devices, e.g. balloons or releasable wires
    • A61B17/12131Occluding by internal devices, e.g. balloons or releasable wires characterised by the type of occluding device
    • A61B17/12136Balloons
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/12Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
    • A61B17/12022Occluding by internal devices, e.g. balloons or releasable wires
    • A61B17/12131Occluding by internal devices, e.g. balloons or releasable wires characterised by the type of occluding device
    • A61B17/1214Coils or wires
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods, e.g. tourniquets
    • A61B2017/00831Material properties
    • A61B2017/00867Material properties shape memory effect
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/12Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
    • A61B17/12022Occluding by internal devices, e.g. balloons or releasable wires
    • A61B2017/1205Introduction devices
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/12Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
    • A61B17/12022Occluding by internal devices, e.g. balloons or releasable wires
    • A61B2017/1205Introduction devices
    • A61B2017/12054Details concerning the detachment of the occluding device from the introduction device
    • A61B2017/12063Details concerning the detachment of the occluding device from the introduction device electrolytically detachable
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B90/00Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges
    • A61B90/39Markers, e.g. radio-opaque or breast lesions markers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/95Instruments specially adapted for placement or removal of stents or stent-grafts
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/95Instruments specially adapted for placement or removal of stents or stent-grafts
    • A61F2002/9505Instruments specially adapted for placement or removal of stents or stent-grafts having retaining means other than an outer sleeve, e.g. male-female connector between stent and instrument
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/95Instruments specially adapted for placement or removal of stents or stent-grafts
    • A61F2002/9505Instruments specially adapted for placement or removal of stents or stent-grafts having retaining means other than an outer sleeve, e.g. male-female connector between stent and instrument
    • A61F2002/9511Instruments specially adapted for placement or removal of stents or stent-grafts having retaining means other than an outer sleeve, e.g. male-female connector between stent and instrument the retaining means being filaments or wires

Definitions

  • This invention relates to devices and methods for placing one or more implants such as helical scaffolds or occlusive members into tubular organs or open regions of the body.
  • the implants may be of types that maintain patency of an open anatomical structure, occlude a selected volume, isolate a region, or collect other occlusive members at a site. Included in the description are devices and methods for deploying the various implants, typically without a sheath, in a serial fashion, and with high adjustibility.
  • Implants such as stents and occlusive coils have been used in patients for a wide variety of reasons. For instance, stents are often used to treat arterial stenosis secondary to atherosclerosis.
  • stents are often used to treat arterial stenosis secondary to atherosclerosis.
  • Various stent designs have been developed and used clinically, but self-expandable and balloon-expandable stent systems and their related deployment techniques are now predominant. Examples of self-expandable stents currently in use are WALLSTENT® stents (Schneider Peripheral Division, Minneapolis, Minn.) and Gianturco stents (Cook, Inc., Bloomington, Ind.).
  • the most commonly used balloon-expandable stent is the PALMAZ® stent (Cordis Corporation, Warren, N.J.).
  • a self-expandable or balloon-expandable stent is advanced over a guidewire and positioned at the target site.
  • a protective sheath or membrane is then retracted proximally to allow expansion of a self-expanding stent.
  • a delivery balloon may be inflated, thereby expanding the stent.
  • balloon-expandable stents by virtue of a large diameter and relative inflexibility, are often unable to reach distal vasculature.
  • repositioning or step-wise release of the stent are usually not available features.
  • occlusive coil placement systems such as systems that deliver detachable platinum coils and GDC® coils also generally do not contain repositionable or step-wise release features.
  • the present invention is a low profile implant delivery device that may be deployed without a sheath, and is designed to release portions of implants simultaneously or sequentially.
  • the implant delivery device includes a noninflatable, elongate delivery guide member having a distal end and configuration that allows it to direct at least one implant having an exterior and interior surface to an anatomical treatment site by manipulation by a user.
  • the at least one implant has a delivery diameter prior to its release, is located proximally of the distal end of the delivery guide member prior to release, and has at least one releasable joint configured to maintain at least a section of the at least one implant at the delivery diameter until release of the at least one releasable joint.
  • the delivery guide member sections that are proximal and distal to the at least one implant also have delivery diameters. These guide member delivery diameters may be substantially equal to the at least one implant delivery diameter prior to implant release.
  • the implant may be a helical scaffold, e.g., a stent, in particular, a self-expandable stent, or it may be an occlusive coil.
  • the implant may be symmetric or asymmetric. In some instances, the implant delivers a therapeutic agent.
  • the delivery guide member may include a wire and/or a tubular member having a lumen. If desired, a radioopaque marker may be included on the delivery guide to aid with its placement.
  • a tubular member When designed to include a tubular member, it co-axially surrounds at least a portion of the delivery guide, and works as a tubular actuator configured to release at least one releasable joint upon distal axial movement along the delivery guide member.
  • the implant delivery device includes an actuator slidably located at least partially within the delivery guide member and is configured to mechanically release at least one releasable joint upon axial movement of the actuator within the delivery guide member.
  • the actuator may also release at least one releasable joint upon rotational movement of the actuator, upon the application of fluid pressure in the delivery guide member lumen, or upon application of a suitable DC current to the at least one releasable joint. Release of the releasable joints using any one of the release mechanisms described above may be sequential, if precise positioning is required, or may be simultaneous. Each feature of each variation may be used on any of the other variations.
  • the implant delivery device may be included in a system for implant delivery which further employs one or more embolic filters at either the proximal or distal section of the delivery guide, or at both the proximal and distal sections of the delivery guide.
  • the system may be used for implant delivery into lumens of tubular organs including, but not limited to, blood vessels (including intracranial vessels, large vessels, peripheral vessels, adjacent aneurysms, arteriovenous malformations, arteriovenous fistulas), ureters, bile ducts, fallopian tubes, cardiac chambers, ducts such as bile ducts and mammary ducts, large and small airways, and hollow organs, e.g., stomach, intestines, and bladder.
  • the implant may be of a design that is of a size that is smaller during delivery and larger after implantation.
  • the design may be used to provide or to maintain patency in an open region of an anatomical structure, or to occlude a site, or to isolate a region (e.g., to close an aneurysm by blocking the aneurysm opening or neck by placement in an adjacent anatomical structure such as an artery or gastrointesinal tubular member), or to corral or collect a number of occlusive devices (e.g., coils or hydratable polymeric noodles) or compositions at a site to be occluded or supported.
  • the implant is located in a gap between proximal and distal sections of the delivery guide member.
  • the system may also be employed for implant delivery into solid organs or tissues including, but not limited to, skin, muscle, fat, brain, liver, kidneys, spleen, and benign and malignant tumors.
  • the implant is delivered to a target site in a blood vessel lumen.
  • the system is a guidewire-less implant delivery system that includes a noninflatable, elongate delivery guide member having a proximal end and a distal end.
  • the guide member is configured to direct at least one implant having an exterior and interior surface to an anatomical treatment site by manipulation by a user.
  • the at least one implant has a delivery diameter prior to release of the at least one implant and is located proximally of the distal end of the delivery guide member prior to release.
  • the at least one releasable joint is configured to maintain at least a section of the at least one implant at the delivery diameter until release of the at least one releasable joint.
  • the guidewire-less system also has a flexibility and remote directability such that a user may direct the distal end of the guide member into, and introduce, the at least one implant into a coronary artery solely by manipulation of the delivery guide member from its proximal end.
  • FIG. 1A is a side view of an implant delivery device with a partial cross-section of the distal section of the delivery guide.
  • FIG. 1B is a cross-sectional view of the delivery guide and implant taken at line 1 B- 1 B in FIG. 1A.
  • FIG. 2 is a side view of an implant delivery device having a tubular member (actuator) attached to the proximal implant end with a partial cross-section of the distal section of the delivery guide.
  • FIG. 3A is a side view of the implant in FIG. 2 being expanded by distally moving the tubular member towards the distal section of the delivery guide.
  • FIG. 3B is a longitudinal cross-sectional view of a distal implant release mechanism.
  • FIGS. 3C 1 and 3 C 2 are longitudinal cross-sectional views of an implant delivery device having a mechanical release mechanism for deploying one end of an implant.
  • FIGS. 3D 1 - 3 D 3 are longitudinal cross-sectional views of an implant delivery device having a mechanical release mechanism for independently releasing the implant ends.
  • FIGS. 3E 1 - 3 E 4 are longitudinal cross-sectional views of an implant delivery device having a hydraulic release mechanism for independently releasing the implant ends.
  • FIGS. 3F 1 - 3 F 2 are longitudinal cross-sectional views of a variation of the hydraulic release mechanism described in 3 E 1 - 3 E 4 .
  • FIGS. 3G 1 - 3 G 3 are longitudinal cross-sectional views of an implant delivery device having a mechanical release mechanism according to another variation of the invention.
  • FIG. 4 is a longitudinal cross-sectional view of an implant delivery device having a mechanical release mechanism according to yet another variation of the invention.
  • FIGS. 5A-5C are longitudinal cross-sectional views of an implant delivery device having an electrolytic implant release mechanism.
  • FIG. 5D shows a longitudinal cross-sectional view of an implant delivery device having an electrolytic release mechanism according to another variation of the invention.
  • FIG. 5E shows a longitudinal cross-sectional view of an implant delivery device having a thermal release mechanism according to one variation of the invention.
  • FIGS. 6A-6D show the general method for serially releasing an implant at a target site.
  • region refers to luminal structures as well as solid organs and solid tissues of the body, whether in their diseased or nondiseased state.
  • luminal structures include, but are not limited to, blood vessels, arteriovenous malformations, aneurysms, arteriovenous fistulas, cardiac chambers, ducts such as bile ducts and mammary ducts, fallopian tubes, ureters, large and small airways, and hollow organs, e.g., stomach, intestines, and bladder.
  • Solid organs or tissues include, but are not limited to, skin, muscle, fat, brain, liver, kidneys, spleen, and benign and malignant tumors.
  • the device assembly generally includes an elongate, perhaps solid delivery guide, an implant, and one or more implant release mechanisms.
  • Guidewire-less systems are used to deliver the one or more implants.
  • guidewire-less it is meant that the system does not require a guiding device of a diameter less than that of the guide member upon which the implant is delivered to reach a chosen implantation site.
  • the guidewire-less system is flexible and remotely directable, the remote directability being such that a user may direct the distal end of the guide member into, and introduce, the at least one implant into a coronary artery solely by manipulation of the delivery guide member from its proximal end.
  • the delivery guide is elongate and has a comparatively small effective diameter. It has the function of permitting delivery of the implant to a selected site and supporting the implant in a collapsed form during positioning and implantation.
  • the delivery guide is usually noninflatable. It may also be solid, or may have a lumen extending therethrough, depending on such factors as the degree of flexibility required, type of associated release mechanism, the constitution material, and the like.
  • the tip of the delivery guide may be tapered and/or straight, curved, or j-shaped, depending on factors such as physician preference, the anatomy of the tubular organ or region of interest, degree of stiffness required, and the like.
  • the delivery guide may or may not include an outer spring coil, for, e.g., fluoroscopic visualization.
  • the delivery guide member and the delivery system into which it is placed desirably serves the function as would a guidewire in, for instance, a cardiac or neurovascular catheterization procedure.
  • the concept that the delivery guide member or system including that guide member and implant(s) is “remotely directable” is to say that the combination of physical parameters of the delivery guide member, implant, and joints are selected to allow advancement of the system much in the same way as would be a guidewire.
  • Such physical parameters include, for instance, choice of materials, stiffness, size of materials, physical or chemical treatment, tapering (if desired), all in the same way that those physical parameters are selected in designing a cardiovascular or neurovascular guidewire.
  • the delivery guide may be made from any biocompatible material including, but not limited to, stainless steel and any of its alloys; titanium alloys, e.g., nickel-titanium alloys; other shape memory alloys; tantalum; polymers, e.g., polyethylene and copolymers thereof, polyethylene terephthalate or copolymers thereof, nylon, silicone, polyurethanes, fluoropolymers, poly (vinylchloride), and combinations thereof.
  • biocompatible material including, but not limited to, stainless steel and any of its alloys; titanium alloys, e.g., nickel-titanium alloys; other shape memory alloys; tantalum; polymers, e.g., polyethylene and copolymers thereof, polyethylene terephthalate or copolymers thereof, nylon, silicone, polyurethanes, fluoropolymers, poly (vinylchloride), and combinations thereof.
  • the diameter of the delivery guide may usually be about 0.013 cm to about 0.130 cm (about 0.005 inches to about 0.05 inches), more usually about 0.013 cm to about 0.076 cm (about 0.005 inches to about 0.03 inches), and more usually still about 0.015 cm to about 0.030 cm (about 0.006 inches to about 0.012 inches). In a preferred variation, the diameter of the delivery guide is approximately about 0.020 cm (about 0.008 inches).
  • a lubricious coating may be placed on the delivery guide if desired to facilitate advancement of the delivery guide.
  • the lubricious coating typically will include hydrophilic polymers such as polyvinylpyrrolidone-based compositions, fluoropolymers such as tetrafluoroethylene, or silicones.
  • the lubricious coating may constitute a hydrophilic gel.
  • the delivery guide may include one or more radioopaque markers that indicates the location of the distal section of the delivery guide upon radiographic imaging. Usually, the marker will be detected by fluoroscopy.
  • the implant itself may be of a shape tailored to achieve a specific purpose. As noted elsewhere, if the purpose of the implant is to provide or to maintain patency of an anatomical structure such as an artery or duct, the implant shape after implantation is itself tubular. The shape may be symmetric or asymmetric, as the purpose dictates.
  • Other shapes including cage structures, may be used to provide patency to vessels or to act as collecting or coralling structures for occlusive members or materials.
  • the implant may have the form of an occlusive coil that remains helical after deployment or assumes a random orientation.
  • the implant for placement into a luminal structure is a helical scaffold, e.g., a stent, but any scaffold shape that maintains patency of a lumen may be used.
  • the stents are typically self-expanding stents, such as described in U.S. Pat. No. 4,768,507 to Fishell et al., U.S. Pat. No. 4,990,155 to Wilkoff et al., and U.S. Pat. No. 4,553,545 to Maass et al.
  • the implant is an occlusive member, e.g., an occlusive coil, such as described in U.S. Pat. No. 5,334,210 to Gianturco and U.S. Pat. No. 5,382,259 to Phelps et al.
  • the interior and exterior surfaces of the implant may be designed to prevent the activation of pathological processes during or after implant deployment.
  • the exterior stent surface may be formed to be smooth to decrease the likelihood of intimal damage upon stent release (which would trigger the inflammatory process and attract atheromatous plaque-forming cells).
  • the interior stent surface may also be smooth to minimize turbulent flow through the stent and decrease the risk of stent thrombosis.
  • Important physical properties of the implant to consider include, but are not limited to: length, (stent) diameter in the expanded state, degree of flexibility and lateral stiffness, and the like. These physical properties will be modified to account for such factors as lumen diameter, length of any stenosis, type of luminal structure, or solid organ or tissue involved.
  • Metals such as stainless steel and tantalum, or metal alloys such as alloys of nickel and titanium, specifically including superelastic alloys such as NITINOL or Elgiloy which are commonly used by those of skill in the art, may be used to form the implants.
  • the implants may also be made from biodegradable polymers, e.g., copolymers of lactic and glycolic acid, or nonbiodegradable polymers, e.g., copolymers of ethylene and vinyl acetate.
  • the implants may also include a therapeutic agent.
  • therapeutic agents that may be used in the implants include, but are not limited to, antibiotics, anticoagulants, antifungal agents, anti-inflammatory agents, antineoplastic agents, antithrombotic agents, endothelialization promoting agents, free radical scavengers, immunosuppressive agents, thrombolytic agents, and any combination thereof. If the implant is a stent, an antithrombotic agent is preferably included.
  • Examples of selective antithrombotic agents include acetylsalicylic acid, argatroban, cilostazol, copidogrel, cloricromen, dalteparin, daltroban, defibrotide, dipyridamole, enoxaparin, epoprostenol, indobufen, iloprost, integrelin, isbogrel, lamifiban, lamoparan, nadroparin, ozagrel, picotamide, plafibride, reviparin sodium, ridogrel, sulfinpyrazone, taprostene, ticlopidine, tinzaparin, tirofiban, triflusal, and any of their derivatives.
  • the therapeutic agent may be coated onto the implant, mixed with a biodegradable polymer or. other suitable temporary carrier and then coated onto the implant, or, when the implant is made from a polymeric material, dispersed throughout the polymer.
  • the implant may include a radioactive material.
  • the radioactive material may be selected on the basis of its use. For instance, the material may be included in an implant where the implant is in the form of a stent that is to be situated over a vascular stenosis. The radioactivity lowers the incidence of re-stenosis. Additionally, the radioactivity may serve the function of a tracer, to allow detection of the location of the implant during the procedure or anytime thereafter. Suitable radioactive tracers include isotopes of gallium, iodine, technetium, and thallium.
  • the implant delivery system includes a delivery guide 100 .
  • Delivery guide 100 has a proximal section 102 and a distal section 104 .
  • An implant in this case depicted as a stent 106 , surrounds a portion of the distal section 104 of the delivery guide, and is releasably attached to the distal section 104 of the delivery guide.
  • the implant 106 as shown in FIG. 1B, is concentrically adjacent to the delivery guide 100 .
  • Implant 106 is shown to be directly attached to, is contiguous to, the delivery guide 100 at the proximal end 108 of the implant and distal end 110 of the implant.
  • implant 106 may be secured to the delivery guide 100 by such generic controllably releasable mechanisms as mechanical, thermal, hydraulic, and electrolytic mechanisms, or a combination thereof. Examples of these release mechanisms will be discussed below.
  • release of the implant 106 from the delivery guide 100 may be achieved through a mechanical detachment process involving, e.g., twisting of the delivery guide, such as described by Amplatz in U.S. Pat. No. 6,468,301, or translational movement of the delivery guide in relation to the implant.
  • Implant release may also be achieved using a thermally detachable joint, such as described in U.S. Pat. No. 5,108,407 to Geremia et al., an electrolytic detachable joint, such as described in U.S. Pat. No. 5,122,136 and U.S. Pat. No. 5,354,295, both to Gulglielmi et al., or a combination thereof.
  • the system includes a tubular member 200 co-axially mounted on a delivery guide 202 .
  • Tubular member 200 may form a component of the delivery guide 202 that cooperates with one or more of the releasable mentioned joints on the implant ( 209 , 211 ) to release those joints (and therefore, release the implant 204 ) upon application of a releasing movement, axial or twisting.
  • An implant e.g., a stent 204
  • the distal end 208 of the tubular member is attached to the proximal end 210 of the stent.
  • the distal end 212 of the stent is attached using a releasable joint 211 to the distal section 206 of the delivery guide 202 .
  • FIG. 3A shows a stent 300 expanding as tubular member 302 is moved distally on the delivery guide 304 , in the direction of the arrow. The stent is then released from the delivery guide.
  • the distal end 306 of the stent is released from a distal section 308 of the delivery guide, followed by release of the proximal end 310 of the stent from the distal end 312 of the tubular member.
  • the stent 300 may be secured to a distal section 308 of the delivery guide by such mechanisms as lock and key arrangements, biocompatible adhesives, soldering, or a combination thereof. Consequently, stent release may be achieved through a mechanical detachment process, a thermal detachment process (e.g., by heat produced from an exothermic reaction), an electrolytic detachment process, or a combination thereof.
  • FIGS. 3B and 3C show yet another variation of a stent release mechanism.
  • brackets 314 may be used to couple the stent 300 to the distal section 308 of the delivery guide. Separation of the stent 306 from the brackets 314 , e.g., by one of the detachment processes mentioned above, releases the distal end 306 of the stent from a distal section 308 of the delivery guide, allowing the stent distal end 306 to expand in the tubular organ.
  • Brackets 314 couple the stent proximal end 310 to the distal region 312 of the tubular member 313 that forms a portion of the delivery guide.
  • the brackets 314 have a ramped region 316 which are proximally adjacent to an enlarged (and perhaps ball- or barrel-shaped) portion 318 of the delivery guide and bracket arms 320 .
  • the delivery guide and stent each have a delivery diameter, and these delivery diameters may be substantially equal prior to release of the stent.
  • the ball-shaped portion 318 forces the ramped regions 316 of the brackets outward from the delivery guide axis, in a radial fashion, causing the bracket arms 320 to be displaced radially outwardly from the proximal end 310 of the stent, thereby releasing the stent proximal end 310 .
  • FIG. 3C 2 shows the results of moving the actuator 305 proximally.
  • the clips ( 316 ) have rotated as shown due to the force exerted upon the ramps ( 317 ) by the ball ( 318 ).
  • the implant ( 320 ) has expanded in diameter from that found in its undelivered form.
  • the actuator may be attached, perhaps with a distal radioopaque coil or directly, to a distal section (not shown) of the guide member.
  • FIG. 3D 1 shows a delivery system 319 in which the two ends of the implant 321 may be independently deployed by using an actuator 304 having a proximal releasing ball 322 and a distal releasing ball 327 .
  • the implant 321 is located in a gap between sections of the delivery guide and are releasably attached to the delivery guide by brackets or clips.
  • the two balls are spaced in such a way that, in the variation shown in FIG. 3D 1 , the distal ball 327 releases the distal end 331 of implant 321 and the proximal ball 322 then releases the proximal end 329 of implant 321 upon additional proximal movement of actuator 304 .
  • This sequence of events is shown in FIGS.
  • the implant 321 is shown to be completely released in FIG. 3D 3 .
  • the implant 321 may be self-expanding, e.g., constructed of a superelastic alloy such as nitinol or another alloy having high elasticity, e.g., an appropriate stainless steel.
  • a structure similar to that shown in FIGS. 3D 1 , 3 D 2 , and 3 D 3 may also be used to deploy an implant using fluid pressure as the releasing impetus.
  • FIGS. 3E 1 , 3 E 2 , 3 E 3 and 3 E 4 show a hydraulic variation. Shown are the delivery guide 350 , having a hollow lumen 352 , a self-expanding implant 354 (shown variously as non-expanded (e.g., in a “first form”) in FIG. 3E 1 , partially expanded in FIG. 3E 2 , and fully expanded in FIGS. 3E 3 and 3 E 4 (e.g., in a “second form”)), and an actuator 356 with a sealing member 358 and a radio-opaque member 360 .
  • a self-expanding implant 354 shown variously as non-expanded (e.g., in a “first form”) in FIG. 3E 1 , partially expanded in FIG. 3E 2 , and fully expanded in FIGS. 3E 3 and 3 E 4 (e.g., in a “second form”)
  • an actuator 356 with a sealing member 358 and a radio-opa
  • the implant 354 (here shown to be a stent or the like) is held to the delivery guide 350 during delivery to the selected treatment site using distal brackets 364 and proximal brackets 362 or clips or the like.
  • the proximal and distal brackets ( 364 , 362 ) either include regions that cooperate with the fluid in lumen 352 to move upon application of increased pressure in that lumen 352 and release the implant 350 or move in concert with a separate pressure sensitive motion component.
  • FIG. 3E 1 shows the actuator 356 as the sealing member 358 approaches the various orifices or openings (proximal orifices 366 and distal orifices 368 ) communicating from the lumen 356 to the hydraulically or fluidly actuatable clips or retaining brackets (proximal brackets 362 and distal brackets 364 ).
  • a radio-opaque marker 360 on the actuator shaft 356 that allows the user to simply line up that actuator marker 360 with a corresponding radio-opaque marker 370 or the delivery guide 350 , increase the pressure in lumen 352 (via syringe, pump, etc.) and deploy the proximal end 371 of implant 354 .
  • the interior pressure raises or rotates the proximal clips or brackets 362 and moves them out of contact with the implant 354 .
  • FIG. 3E 2 shows the movement of the proximal end of implant 354 away from the delivery guide 350 .
  • FIG. 3E 3 shows the axial movement of actuator 356 distally to a position where the sealing member 358 is positioned to actuate distal clips or brackets 364 and release the distal end of implant.
  • a radio-opaque marker 374 (perhaps with an additional identification band 376 ) has been depicted to show alignment of the radio-opaque marker or band 360 on the actuator shaft 356 prior to the increase in pressure for deployment.
  • FIG. 3E 4 shows final deployment at the implant 354 and proximal movement at the actuator 356 , just prior to withdrawal of the delivery guide 350 .
  • the distal and proximal clips or brackets ( 362 , 364 ) have relaxed to the surface of the delivery guide 350 .
  • FIGS. 3F 1 and 3 F 2 Alternatives to certain of the elements shown in the variation found in FIGS. 3E 1 to 3 E 4 is seen in FIGS. 3F 1 and 3 F 2 and includes, e.g., a cover element 380 to block or cover proximal orifices 366 during the pressurization of the distal orifices 368 .
  • the cover element 380 includes holes 382 to allow fluid flow past the cover element 380 .
  • FIG. 3G 1 shows a variation of the described system in which an implant or stent 371 is maintained in position on a hollow delivery guide 373 using spring clips 375 proximally and 377 distally.
  • the spring clips hold the implant 371 in place during delivery and against guide member 373 .
  • An actuator 379 is used to remove the clips 375 , 377 sequentially and to release each-end of implant 371 in an independent fashion. Clips 375 and 377 , after actuation or release, remain interior to the guide member 373 for later removal with that guide member.
  • the system shown in FIGS. 3G 1 , 3 G 2 and 3 G 3 may be used to deliver a number of implants in a sequential fashion.
  • the actuator 379 is able to slide past the site on guide member 373 where the clips 375 , 377 resided prior to implant 371 deployment, down to and distally to a site on the guide member having another implant for subsequent delivery. Consequently, an arrangement such as this may be used to deploy, in a sequential fashion, a number of stents or the like without withdrawal of the guide member.
  • the clips 375 and 377 are spring-biased to collapse within the lumen 381 of the guide member 373 once they are pushed into the respective slots 383 provided for such retraction.
  • Such spring loaded clips retain the self expanding stent or implant 371 onto the face of guide member 373 .
  • Each of clips 375 , 377 are shown in this variation to have hook members 387 , 389 that engage the implant 371 , often axially stretching the implant 371 and maintaining the delivery radius of the implant 371 as shown.
  • actuator 379 is pushed distally along the outer surface of guide member 373 until it contacts the proximal end of clip 375 . Further distal movement of actuator 379 urges clip 375 into lumen 381 thereby rotating horn 387 out of cooperating receptacle area in implant 371 .
  • FIG. 3G 2 shows the results of such movement after clip 375 has completed its springed closure within lumen 381 .
  • the proximal end of implant 371 has expanded and yet the distal end of implant 371 remains closed and hooked to distal clip 377 .
  • This semi-open condition allows for some adjustment of the implant if needed.
  • FIG. 3G 3 shows the results of additional distal movement of actuator 379 until it contacts distal clip 377 (shown in FIG. 3G 3 in its collapsed form ) and thereby allowing the distal end of implant 371 to self-expand into the chosen treatment site.
  • FIG. 3G 3 shows that guide member 379 is free.
  • Implant 371 is shown in its self expanded form no longer adjacent the central guide member 379 .
  • Actuator 379 is situated within implant 371 and is no longer in contact with proximal clip 375 nor distal clip 377 . Actuator 379 is thus able to continue distally to another implant containing site positioned in a more distal site on the guide member 373 .
  • FIGS. 3G 1 , 3 G 2 , 3 G 3 may be modified in such a way that the actuator is interior to the lumen of the guide member and deploys the implant upon distal movement of the actuator by providing an actuator with a slot or other “room-making” provisions in the actuator. The actuator and any retained clips would then be used to actuate the clips in the next more distal implant if so desired.
  • the system releases an implant (shown as a stent 404 in FIG. 4) attached to a delivery guide 400 by one or more attachment arms 402 positioned, e.g., at the implant proximal and distal ends, by sliding a tubular member 406 , mounted co-axially on the delivery guide 400 , distally over the delivery guide 400 .
  • the stent 404 is secured to the delivery guide 400 when the attachment arms 402 are in a radially expanded configuration (as illustrated in FIG. 4).
  • the tubular member 406 urges the attachment arms 402 into a compressed configuration as it slides distally over the delivery guide 400 , in the direction of the arrow.
  • the attachment arms 402 When the attachment arms 402 are compressed by the tubular member 406 , they are moved inward from the stent 404 , toward the central axis of the delivery guide 400 , thereby releasing the stent 404 from the delivery guide 400 .
  • Stent detachment occurs in a serial fashion as the tubular member 406 is moved distally, with detachment of the stent proximal end 408 occurring before detachment at the stent distal end 410 . Consequently, if the stent position requires readjustment after detachment of the stent proximal end, the stent may be repositioned prior to detaching the stent distal end.
  • the tubular member is a balloon catheter.
  • the attachment arms 402 are generally made from the same materials as the delivery guide 400 , e.g., stainless steel or nickel-titanium alloy, and will typically have a length, thickness, shape, and flexibility appropriate for its intended mechanism of release.
  • the distal ends 412 of the attachment arms may be of any design, so long as one or more of them, when in a radially expanded configuration, secures a portion of a stent to a delivery guide, and when in a compressed configuration, releases that same stent portion from the delivery guide.
  • the tubular member may be a thin-walled tube (e.g., approximately 0.005 cm (0.002 inches) in thickness) with an outside diameter ranging from about 0.025 cm to about 0.139 cm (0.010 inches to about 0.055 inches), more usually from about 0.025 cm to about 0.05 cm (0.010 inches to about 0.020 inches), and more usually still from about 0.025 cm to about 0.035 cm (0.010 inches to about 0.014 inches).
  • they may be made from various metals or metal alloys, including, but not limited to, stainless steel and nickel-titanium alloy, or from various polymers, such as polyvinyl chloride, polyethylene, polyethylene terephthalate, and polyurethane.
  • FIGS. 5A, 5B, and 5 C show a variation of the described delivery system 500 in which a member of electrolytic delivery joints are used to deploy an implant 502 , such as a stent.
  • the electrolytic delivery joints shown here are well known as controllable delivery joints for placement of vaso-occlusive coils.
  • One such commercially available device using an electrolytically detachable joint is sold by Target Therapeutics, a subsidiary of Boston Scientific Corp., as the Guglielni Detachable Coil (or “GDC”).
  • GDC Guglielni Detachable Coil
  • the electrolytically erodible joint is a section of an electrical circuit that is not insulated and is of a metallic material that does not form insulating oxides when exposed to an aqueous environment (e.g., aluminum and tantalum) and is sufficiently “non-noble” that is will either electrolytically erode by ionic dissolution into an anatomical fluid or, perhaps, electrochemically erode by forming readily soluble oxides or salts.
  • an aqueous environment e.g., aluminum and tantalum
  • the erodible joint 504 shown in FIG. 5C is a bare metal of a size, diameter, etc. that erodes away when a current is applied to insulated wire 506 .
  • the current flow is from a power supply through insulated wire 506 , bare joint 504 , into the ionic anatomical fluid surrounding the site to be treated, and back to a return electrode situated perhaps on the patient's skin and then back to the power supply.
  • the current flows through the circuit so long as the joint 504 exists.
  • FIG. 5A shows a device having several joints ( 504 , 508 , 510 , 512 ) that each may be independently severed to controllably deploy the implant 502 .
  • Implant 502 is shown having coils ( 514 , 516 ) that are terminated at each end by an erodible joint and that, prior to the severing of ajoint, hold this implant 502 to the surface of the delivery member 520 .
  • the implant 500 is self-expanding, once released.
  • the wires forming the two coils in this variation slide within the implant or “uncoil” and thereby allow the implant body itself to expand.
  • the coils may comprise (if electrically connected to the erodible joint) a metal that is higher in the Mendelev Electromotive Series than is the composition at the electrolytic joint or the coils may comprise a polymer that may be bio-erodible or not.
  • a suitable way to assure that the coils ( 514 , 516 ) maintain the low profile of the implant 502 during delivery is via the placement of the various conductive wires ( 506 , 516 , 518 , 520 ) through the adjacent holes ( 524 , 526 , 528 ) and fill the holes with e.g., an epoxy to hold all in place. Independently causing current to flow through each of the joints will release the implant in the region of the released joint Once all joints are eroded, the implant is released.
  • detachment from a delivery guide is not so limited.
  • the stent is attached to the delivery guide at one or more positions along the length of the stent, in addition to attachment at the proximal and distal implant ends. Once the distal stent end is released, the additional attachments may be independently released until detachment at the proximal implant end releases the implant entirely from the delivery guide. Serial release may provide better control of positioning in tubular organs.
  • FIGS. 5D and 5E show in more detail, the components of an electrolytic joint (as may be found in FIGS. 5A, 5B and 5 C) and another electrically actuated joint using a meltable or softenable or polymerically sizable joint.
  • FIG. 5D shows the insulated wire 524 with insulation 523 and conductor 525 .
  • the electrolytic joint 504 is also shown.
  • the wire 524 is shown to be secured into the delivery guide wall 520 by, e.g., an epoxy 527 , an alternative or cooperative band or component 529 holding the wire 524 to the surface of guide member 520 is also shown.
  • the implant of 502 expands and leaves the securement band 529 on the delivery guide 520 .
  • FIG. 5E shows a similar variation but the joint comprises a thermoplastic adhesive or shape changing polymer 531 situated on the end of wire 525 and within a cup or other receptacle 533 .
  • the adhesive is of the type that changes form or viscosity upon application of current to the joint.
  • the thermoplastic is rendered conductive, but resistive, by introduction of material such as carbon black into the polymeric adhesive. As soon as the polymer changes its shape, form, or phase, the implant expands to the desired form about the central guide member 520 again, the wire may be held in place with an adhesive 527 if so desired.
  • the implant delivery devices described herewith may include multiple implants on a single delivery guide or may be used in conjunction with other instruments, as seen appropriate, to treat the target site.
  • the tubular organ of interest is percutaneously accessed, but the method of accessing will usually be dependent on the anatomy of the organ, medical condition being treated, health status of the subject, and the like. Consequently, access by a laparoscopic or open procedure may also be obtained.
  • FIGS. 6A-6D show the general method of deploying a stent using my described system.
  • a delivery guide 602 is placed through the selected area of stenosis 604 at the target site.
  • a balloon catheter 606 is then advanced over the delivery guide 602 , and balloon angioplasty performed to dilate the area of stenosis 604 (FIG. 6B).
  • the balloon catheter 606 is then retracted proximally and the delivery guide 602 exchanged for a stent delivery device 608 (FIG. 6C). Appropriate placement of the stent is guided by radioopaque markers 616 on the delivery guide 612 .
  • the distal end 610 of the stent is then released from the delivery guide 612 .
  • stent position may again be checked by verifying the location of the radioopaque markers.
  • the proximal stent end 614 is then released from the delivery guide 612 .
  • an embolic filter may be used during stent deployment to filter any debris generated during the procedure.
  • the filter will usually be attached to the delivery guide such that it filters debris distal to the stent, but may also be attached to the delivery guide proximal to the stent, or both distal and proximal to the stent.
  • the filter may be of any design, as long as it does not affect the substantially atraumatic, low profile, and controlled release characteristics of the stent delivery device.
  • the filter is basket-shaped, and made from a shape-memory material, e.g., an alloy of titanium and nickel.
  • the filter will usually be contained within the balloon catheter lumen, and deployed to its pre-designed shape once the balloon catheter is removed. Following placement of the stent, the balloon catheter may be advanced over the delivery guide to enclose the filter with any accumulated debris. The balloon catheter, filter, and delivery guide may then be removed from the body.
  • the implant delivery system may be used in mammalian subjects, preferably humans. Mammals include, but are not limited to, primates, farm animals, sport animals, cats, dogs, rabbits, mice, and rats.
  • the system may be employed for implant delivery into lumens of tubular organs including, but not limited to, blood vessels (including intracranial vessels, large vessels, peripheral vessels, aneurysms, arteriovenous malformations, arteriovenous fistulas), ureters, bile ducts, fallopian tubes, cardiac chambers, ducts such as bile ducts and mammary ducts, large and small airways, and hollow organs, e.g., stomach, intestines, and bladder.
  • the system may also be employed for implant delivery into solid organs or tissues including, but not limited to, skin, muscle, fat, brain, liver, kidneys, spleen, and benign and malignant tumors.
  • the implant is delivered to a target site in a blood vessel lumen.
  • the system may generally be used to treat stenosis of various tubular organs, arising from such etiologies as atherosclerosis, autoimmune conditions, scarring, or exterior compression, e.g., as may be seen with a neoplastic process.
  • the system may also be used to treat medical conditions in which luminal occlusion is desired, e.g., to treat aneurysms, arteriovenous fistulas, and arteriovenous malformations.
  • the system may be employed to deliver implants into such areas as joint spaces, spinal discs, and the intraperitoneal or extraperitoneal spaces.

Abstract

The invention provides an atraumatic, low profile device for the delivery of one or more implants into tubular organs or open regions of the body. The implant delivery device may simultaneously or independently release portions of the implant, e.g., the proximal and distal ends of the implant. This independent release feature allows better implant positioning at the target site. Upon deployment, the implants may be placed at the target site without a sheath.

Description

    FIELD OF THE INVENTION
  • This invention relates to devices and methods for placing one or more implants such as helical scaffolds or occlusive members into tubular organs or open regions of the body. The implants may be of types that maintain patency of an open anatomical structure, occlude a selected volume, isolate a region, or collect other occlusive members at a site. Included in the description are devices and methods for deploying the various implants, typically without a sheath, in a serial fashion, and with high adjustibility. [0001]
  • BACKGROUND OF THE INVENTION
  • Implants such as stents and occlusive coils have been used in patients for a wide variety of reasons. For instance, stents are often used to treat arterial stenosis secondary to atherosclerosis. Various stent designs have been developed and used clinically, but self-expandable and balloon-expandable stent systems and their related deployment techniques are now predominant. Examples of self-expandable stents currently in use are WALLSTENT® stents (Schneider Peripheral Division, Minneapolis, Minn.) and Gianturco stents (Cook, Inc., Bloomington, Ind.). The most commonly used balloon-expandable stent is the PALMAZ® stent (Cordis Corporation, Warren, N.J.). [0002]
  • Typically, after balloon angioplasty has been performed, either a self-expandable or balloon-expandable stent is advanced over a guidewire and positioned at the target site. A protective sheath or membrane is then retracted proximally to allow expansion of a self-expanding stent. Alternatively, a delivery balloon may be inflated, thereby expanding the stent. [0003]
  • Despite improvements in delivery systems, balloon design, and stent design, these over-the-guidewire and/or sheathed self-expanding stent deployment systems still have their limitations. For instance, sheathed stents tend to move forward when the sheath is pulled back, deploying them imprecisely. The sheathed design also requires that the stent delivery system be larger in diameter and less flexible. Furthermore, for sheathed systems, the interventional procedure may only proceed if the vessel of interest is of sufficiently large diameter to allow sheath placement to avoid significant damage to the luminal surface of the vessel. Moreover, balloon-expandable stents, by virtue of a large diameter and relative inflexibility, are often unable to reach distal vasculature. For both self-expandable and balloon-expandable stent deployment systems, repositioning or step-wise release of the stent are usually not available features. Similarly, occlusive coil placement systems such as systems that deliver detachable platinum coils and GDC® coils also generally do not contain repositionable or step-wise release features. [0004]
  • Consequently, a smaller diameter (lower profile), repositionable implant deployment device that releases an implant into, or upon, a body region in a more precise, continuous or step-wise fashion, without the use of a sheath or balloon would provide significant benefit to patients with various medical conditions. [0005]
  • SUMMARY OF THE INVENTION
  • The present invention is a low profile implant delivery device that may be deployed without a sheath, and is designed to release portions of implants simultaneously or sequentially. [0006]
  • In one variation, the implant delivery device includes a noninflatable, elongate delivery guide member having a distal end and configuration that allows it to direct at least one implant having an exterior and interior surface to an anatomical treatment site by manipulation by a user. The at least one implant has a delivery diameter prior to its release, is located proximally of the distal end of the delivery guide member prior to release, and has at least one releasable joint configured to maintain at least a section of the at least one implant at the delivery diameter until release of the at least one releasable joint. The delivery guide member sections that are proximal and distal to the at least one implant also have delivery diameters. These guide member delivery diameters may be substantially equal to the at least one implant delivery diameter prior to implant release. [0007]
  • The implant may be a helical scaffold, e.g., a stent, in particular, a self-expandable stent, or it may be an occlusive coil. The implant may be symmetric or asymmetric. In some instances, the implant delivers a therapeutic agent. [0008]
  • the delivery guide member may include a wire and/or a tubular member having a lumen. If desired, a radioopaque marker may be included on the delivery guide to aid with its placement. When designed to include a tubular member, it co-axially surrounds at least a portion of the delivery guide, and works as a tubular actuator configured to release at least one releasable joint upon distal axial movement along the delivery guide member. [0009]
  • In another variation, the implant delivery device includes an actuator slidably located at least partially within the delivery guide member and is configured to mechanically release at least one releasable joint upon axial movement of the actuator within the delivery guide member. In other variations, the actuator may also release at least one releasable joint upon rotational movement of the actuator, upon the application of fluid pressure in the delivery guide member lumen, or upon application of a suitable DC current to the at least one releasable joint. Release of the releasable joints using any one of the release mechanisms described above may be sequential, if precise positioning is required, or may be simultaneous. Each feature of each variation may be used on any of the other variations. [0010]
  • The implant delivery device may be included in a system for implant delivery which further employs one or more embolic filters at either the proximal or distal section of the delivery guide, or at both the proximal and distal sections of the delivery guide. [0011]
  • The system may be used for implant delivery into lumens of tubular organs including, but not limited to, blood vessels (including intracranial vessels, large vessels, peripheral vessels, adjacent aneurysms, arteriovenous malformations, arteriovenous fistulas), ureters, bile ducts, fallopian tubes, cardiac chambers, ducts such as bile ducts and mammary ducts, large and small airways, and hollow organs, e.g., stomach, intestines, and bladder. The implant may be of a design that is of a size that is smaller during delivery and larger after implantation. The design may be used to provide or to maintain patency in an open region of an anatomical structure, or to occlude a site, or to isolate a region (e.g., to close an aneurysm by blocking the aneurysm opening or neck by placement in an adjacent anatomical structure such as an artery or gastrointesinal tubular member), or to corral or collect a number of occlusive devices (e.g., coils or hydratable polymeric noodles) or compositions at a site to be occluded or supported. In another variation, the implant is located in a gap between proximal and distal sections of the delivery guide member. The system may also be employed for implant delivery into solid organs or tissues including, but not limited to, skin, muscle, fat, brain, liver, kidneys, spleen, and benign and malignant tumors. Preferably, the implant is delivered to a target site in a blood vessel lumen. [0012]
  • In a general aspect, the system is a guidewire-less implant delivery system that includes a noninflatable, elongate delivery guide member having a proximal end and a distal end. The guide member is configured to direct at least one implant having an exterior and interior surface to an anatomical treatment site by manipulation by a user. The at least one implant has a delivery diameter prior to release of the at least one implant and is located proximally of the distal end of the delivery guide member prior to release. The at least one releasable joint is configured to maintain at least a section of the at least one implant at the delivery diameter until release of the at least one releasable joint. The guidewire-less system also has a flexibility and remote directability such that a user may direct the distal end of the guide member into, and introduce, the at least one implant into a coronary artery solely by manipulation of the delivery guide member from its proximal end.[0013]
  • BRIEF DESCRIPTION OF THE DRAWING(S)
  • FIG. 1A is a side view of an implant delivery device with a partial cross-section of the distal section of the delivery guide. [0014]
  • FIG. 1B is a cross-sectional view of the delivery guide and implant taken at line [0015] 1B-1B in FIG. 1A.
  • FIG. 2 is a side view of an implant delivery device having a tubular member (actuator) attached to the proximal implant end with a partial cross-section of the distal section of the delivery guide. [0016]
  • FIG. 3A is a side view of the implant in FIG. 2 being expanded by distally moving the tubular member towards the distal section of the delivery guide. [0017]
  • FIG. 3B is a longitudinal cross-sectional view of a distal implant release mechanism. [0018]
  • FIGS. 3C[0019] 1 and 3C2 are longitudinal cross-sectional views of an implant delivery device having a mechanical release mechanism for deploying one end of an implant.
  • FIGS. 3D[0020] 1-3D3 are longitudinal cross-sectional views of an implant delivery device having a mechanical release mechanism for independently releasing the implant ends.
  • FIGS. 3E[0021] 1-3E4 are longitudinal cross-sectional views of an implant delivery device having a hydraulic release mechanism for independently releasing the implant ends.
  • FIGS. 3F[0022] 1-3F2 are longitudinal cross-sectional views of a variation of the hydraulic release mechanism described in 3E1-3E4.
  • FIGS. 3G[0023] 1-3G3 are longitudinal cross-sectional views of an implant delivery device having a mechanical release mechanism according to another variation of the invention.
  • FIG. 4 is a longitudinal cross-sectional view of an implant delivery device having a mechanical release mechanism according to yet another variation of the invention. [0024]
  • FIGS. 5A-5C are longitudinal cross-sectional views of an implant delivery device having an electrolytic implant release mechanism. [0025]
  • FIG. 5D shows a longitudinal cross-sectional view of an implant delivery device having an electrolytic release mechanism according to another variation of the invention. [0026]
  • FIG. 5E shows a longitudinal cross-sectional view of an implant delivery device having a thermal release mechanism according to one variation of the invention. [0027]
  • FIGS. 6A-6D show the general method for serially releasing an implant at a target site.[0028]
  • DETAILED DESCRIPTION OF THE INVENTION
  • Described here are devices, systems, and methods for delivering implants into both open and solid regions of the body. The term “region” as used herein refers to luminal structures as well as solid organs and solid tissues of the body, whether in their diseased or nondiseased state. Examples of luminal structures include, but are not limited to, blood vessels, arteriovenous malformations, aneurysms, arteriovenous fistulas, cardiac chambers, ducts such as bile ducts and mammary ducts, fallopian tubes, ureters, large and small airways, and hollow organs, e.g., stomach, intestines, and bladder. Solid organs or tissues include, but are not limited to, skin, muscle, fat, brain, liver, kidneys, spleen, and benign and malignant tumors. [0029]
  • The device assembly generally includes an elongate, perhaps solid delivery guide, an implant, and one or more implant release mechanisms. Guidewire-less systems are used to deliver the one or more implants. By “guidewire-less” it is meant that the system does not require a guiding device of a diameter less than that of the guide member upon which the implant is delivered to reach a chosen implantation site. Instead, the guidewire-less system is flexible and remotely directable, the remote directability being such that a user may direct the distal end of the guide member into, and introduce, the at least one implant into a coronary artery solely by manipulation of the delivery guide member from its proximal end. [0030]
  • Delivery Guide or Delivery Guide Member
  • The delivery guide is elongate and has a comparatively small effective diameter. It has the function of permitting delivery of the implant to a selected site and supporting the implant in a collapsed form during positioning and implantation. The delivery guide is usually noninflatable. It may also be solid, or may have a lumen extending therethrough, depending on such factors as the degree of flexibility required, type of associated release mechanism, the constitution material, and the like. The tip of the delivery guide may be tapered and/or straight, curved, or j-shaped, depending on factors such as physician preference, the anatomy of the tubular organ or region of interest, degree of stiffness required, and the like. The delivery guide may or may not include an outer spring coil, for, e.g., fluoroscopic visualization. [0031]
  • The delivery guide member and the delivery system into which it is placed desirably serves the function as would a guidewire in, for instance, a cardiac or neurovascular catheterization procedure. The concept that the delivery guide member or system including that guide member and implant(s) is “remotely directable” is to say that the combination of physical parameters of the delivery guide member, implant, and joints are selected to allow advancement of the system much in the same way as would be a guidewire. Such physical parameters include, for instance, choice of materials, stiffness, size of materials, physical or chemical treatment, tapering (if desired), all in the same way that those physical parameters are selected in designing a cardiovascular or neurovascular guidewire. [0032]
  • The delivery guide may be made from any biocompatible material including, but not limited to, stainless steel and any of its alloys; titanium alloys, e.g., nickel-titanium alloys; other shape memory alloys; tantalum; polymers, e.g., polyethylene and copolymers thereof, polyethylene terephthalate or copolymers thereof, nylon, silicone, polyurethanes, fluoropolymers, poly (vinylchloride), and combinations thereof. The diameter of the delivery guide may usually be about 0.013 cm to about 0.130 cm (about 0.005 inches to about 0.05 inches), more usually about 0.013 cm to about 0.076 cm (about 0.005 inches to about 0.03 inches), and more usually still about 0.015 cm to about 0.030 cm (about 0.006 inches to about 0.012 inches). In a preferred variation, the diameter of the delivery guide is approximately about 0.020 cm (about 0.008 inches). [0033]
  • A lubricious coating may be placed on the delivery guide if desired to facilitate advancement of the delivery guide. The lubricious coating typically will include hydrophilic polymers such as polyvinylpyrrolidone-based compositions, fluoropolymers such as tetrafluoroethylene, or silicones. In one variation, the lubricious coating may constitute a hydrophilic gel. Furthermore, the delivery guide may include one or more radioopaque markers that indicates the location of the distal section of the delivery guide upon radiographic imaging. Usually, the marker will be detected by fluoroscopy. [0034]
  • Implants
  • The implant itself may be of a shape tailored to achieve a specific purpose. As noted elsewhere, if the purpose of the implant is to provide or to maintain patency of an anatomical structure such as an artery or duct, the implant shape after implantation is itself tubular. The shape may be symmetric or asymmetric, as the purpose dictates. [0035]
  • Other shapes, including cage structures, may be used to provide patency to vessels or to act as collecting or coralling structures for occlusive members or materials. [0036]
  • If the purpose or task is to occlude a lumen or open region, the implant may have the form of an occlusive coil that remains helical after deployment or assumes a random orientation. [0037]
  • In one variation, the implant for placement into a luminal structure is a helical scaffold, e.g., a stent, but any scaffold shape that maintains patency of a lumen may be used. The stents are typically self-expanding stents, such as described in U.S. Pat. No. 4,768,507 to Fishell et al., U.S. Pat. No. 4,990,155 to Wilkoff et al., and U.S. Pat. No. 4,553,545 to Maass et al. In another variation, the implant is an occlusive member, e.g., an occlusive coil, such as described in U.S. Pat. No. 5,334,210 to Gianturco and U.S. Pat. No. 5,382,259 to Phelps et al. [0038]
  • The interior and exterior surfaces of the implant may be designed to prevent the activation of pathological processes during or after implant deployment. For example, in the case of a vascular stent, the exterior stent surface may be formed to be smooth to decrease the likelihood of intimal damage upon stent release (which would trigger the inflammatory process and attract atheromatous plaque-forming cells). The interior stent surface may also be smooth to minimize turbulent flow through the stent and decrease the risk of stent thrombosis. [0039]
  • Important physical properties of the implant to consider include, but are not limited to: length, (stent) diameter in the expanded state, degree of flexibility and lateral stiffness, and the like. These physical properties will be modified to account for such factors as lumen diameter, length of any stenosis, type of luminal structure, or solid organ or tissue involved. [0040]
  • Metals such as stainless steel and tantalum, or metal alloys such as alloys of nickel and titanium, specifically including superelastic alloys such as NITINOL or Elgiloy which are commonly used by those of skill in the art, may be used to form the implants. However, the implants may also be made from biodegradable polymers, e.g., copolymers of lactic and glycolic acid, or nonbiodegradable polymers, e.g., copolymers of ethylene and vinyl acetate. [0041]
  • The implants may also include a therapeutic agent. Examples of therapeutic agents that may be used in the implants include, but are not limited to, antibiotics, anticoagulants, antifungal agents, anti-inflammatory agents, antineoplastic agents, antithrombotic agents, endothelialization promoting agents, free radical scavengers, immunosuppressive agents, thrombolytic agents, and any combination thereof. If the implant is a stent, an antithrombotic agent is preferably included. [0042]
  • Examples of selective antithrombotic agents include acetylsalicylic acid, argatroban, cilostazol, copidogrel, cloricromen, dalteparin, daltroban, defibrotide, dipyridamole, enoxaparin, epoprostenol, indobufen, iloprost, integrelin, isbogrel, lamifiban, lamoparan, nadroparin, ozagrel, picotamide, plafibride, reviparin sodium, ridogrel, sulfinpyrazone, taprostene, ticlopidine, tinzaparin, tirofiban, triflusal, and any of their derivatives. [0043]
  • The therapeutic agent may be coated onto the implant, mixed with a biodegradable polymer or. other suitable temporary carrier and then coated onto the implant, or, when the implant is made from a polymeric material, dispersed throughout the polymer. [0044]
  • The implant may include a radioactive material. The radioactive material may be selected on the basis of its use. For instance, the material may be included in an implant where the implant is in the form of a stent that is to be situated over a vascular stenosis. The radioactivity lowers the incidence of re-stenosis. Additionally, the radioactivity may serve the function of a tracer, to allow detection of the location of the implant during the procedure or anytime thereafter. Suitable radioactive tracers include isotopes of gallium, iodine, technetium, and thallium. [0045]
  • Release Mechanism
  • In one variation of the generic implant delivery system, as shown in FIG. 1A, the implant delivery system includes a [0046] delivery guide 100. Delivery guide 100 has a proximal section 102 and a distal section 104. An implant, in this case depicted as a stent 106, surrounds a portion of the distal section 104 of the delivery guide, and is releasably attached to the distal section 104 of the delivery guide. The implant 106, as shown in FIG. 1B, is concentrically adjacent to the delivery guide 100. Although I show the stent in FIGS. 1A and 1B as the implant (106), I depict it in this fashion solely for the illustrative purpose of indicating the siting of the implant 106 on the delivery guide 100 with the distal and proximal implant release mechanism (109, 111). Various implant release mechanisms or structures are discussed in greater detail below.
  • Implant [0047] 106 is shown to be directly attached to, is contiguous to, the delivery guide 100 at the proximal end 108 of the implant and distal end 110 of the implant. In the system shown in FIG. 1A, implant 106 may be secured to the delivery guide 100 by such generic controllably releasable mechanisms as mechanical, thermal, hydraulic, and electrolytic mechanisms, or a combination thereof. Examples of these release mechanisms will be discussed below.
  • Consequently, release of the implant [0048] 106 from the delivery guide 100 may be achieved through a mechanical detachment process involving, e.g., twisting of the delivery guide, such as described by Amplatz in U.S. Pat. No. 6,468,301, or translational movement of the delivery guide in relation to the implant. Implant release may also be achieved using a thermally detachable joint, such as described in U.S. Pat. No. 5,108,407 to Geremia et al., an electrolytic detachable joint, such as described in U.S. Pat. No. 5,122,136 and U.S. Pat. No. 5,354,295, both to Gulglielmi et al., or a combination thereof.
  • In another variation, and as shown in FIG. 2, the system includes a [0049] tubular member 200 co-axially mounted on a delivery guide 202. Tubular member 200 may form a component of the delivery guide 202 that cooperates with one or more of the releasable mentioned joints on the implant (209, 211) to release those joints (and therefore, release the implant 204) upon application of a releasing movement, axial or twisting. An implant, e.g., a stent 204, is mounted on a distal section 206 of the delivery guide and the distal end 208 of the tubular member is attached to the proximal end 210 of the stent. The distal end 212 of the stent is attached using a releasable joint 211 to the distal section 206 of the delivery guide 202.
  • As mentioned above, I may use a tubular member mounted coaxially about the delivery guide, that slides axially about that delivery guide, as a actuator to release the implant. The outer tubular member may also be used to pre-position the implant. For instance, prior to release, the outer tubular member may be used to expand the implant to therefore obscure its placement, and so to permit adjustment of the placement. FIG. 3A shows a [0050] stent 300 expanding as tubular member 302 is moved distally on the delivery guide 304, in the direction of the arrow. The stent is then released from the delivery guide. Specifically, the distal end 306 of the stent is released from a distal section 308 of the delivery guide, followed by release of the proximal end 310 of the stent from the distal end 312 of the tubular member. As mentioned above, the stent 300 may be secured to a distal section 308 of the delivery guide by such mechanisms as lock and key arrangements, biocompatible adhesives, soldering, or a combination thereof. Consequently, stent release may be achieved through a mechanical detachment process, a thermal detachment process (e.g., by heat produced from an exothermic reaction), an electrolytic detachment process, or a combination thereof.
  • FIGS. 3B and 3C show yet another variation of a stent release mechanism. In FIG. 3B, [0051] brackets 314 may be used to couple the stent 300 to the distal section 308 of the delivery guide. Separation of the stent 306 from the brackets 314, e.g., by one of the detachment processes mentioned above, releases the distal end 306 of the stent from a distal section 308 of the delivery guide, allowing the stent distal end 306 to expand in the tubular organ.
  • Controllable release of an end of an implant from the delivery guide may be accomplished using the structure of FIG. 3C[0052] 1. Brackets 314 couple the stent proximal end 310 to the distal region 312 of the tubular member 313 that forms a portion of the delivery guide. The brackets 314 have a ramped region 316 which are proximally adjacent to an enlarged (and perhaps ball- or barrel-shaped) portion 318 of the delivery guide and bracket arms 320. The delivery guide and stent each have a delivery diameter, and these delivery diameters may be substantially equal prior to release of the stent. When the actuator 305 is moved proximally, as shown by the direction of the arrow, the ball-shaped portion 318 forces the ramped regions 316 of the brackets outward from the delivery guide axis, in a radial fashion, causing the bracket arms 320 to be displaced radially outwardly from the proximal end 310 of the stent, thereby releasing the stent proximal end 310.
  • FIG. 3C[0053] 2 shows the results of moving the actuator 305 proximally. The clips (316) have rotated as shown due to the force exerted upon the ramps (317) by the ball (318). The implant (320) has expanded in diameter from that found in its undelivered form.
  • The actuator may be attached, perhaps with a distal radioopaque coil or directly, to a distal section (not shown) of the guide member. [0054]
  • FIG. 3D[0055] 1, shows a delivery system 319 in which the two ends of the implant 321 may be independently deployed by using an actuator 304 having a proximal releasing ball 322 and a distal releasing ball 327. The implant 321 is located in a gap between sections of the delivery guide and are releasably attached to the delivery guide by brackets or clips. The two balls are spaced in such a way that, in the variation shown in FIG. 3D1, the distal ball 327 releases the distal end 331 of implant 321 and the proximal ball 322 then releases the proximal end 329 of implant 321 upon additional proximal movement of actuator 304. This sequence of events is shown in FIGS. 3D1, 3D2, and 3D3. The implant 321, is shown to be completely released in FIG. 3D3. In this variation, the implant 321 may be self-expanding, e.g., constructed of a superelastic alloy such as nitinol or another alloy having high elasticity, e.g., an appropriate stainless steel.
  • A structure similar to that shown in FIGS. 3D[0056] 1, 3D2, and 3D3 may also be used to deploy an implant using fluid pressure as the releasing impetus.
  • FIGS. 3E[0057] 1, 3E2, 3E3 and 3E4 show a hydraulic variation. Shown are the delivery guide 350, having a hollow lumen 352, a self-expanding implant 354 (shown variously as non-expanded (e.g., in a “first form”) in FIG. 3E1, partially expanded in FIG. 3E2, and fully expanded in FIGS. 3E3 and 3E4 (e.g., in a “second form”)), and an actuator 356 with a sealing member 358 and a radio-opaque member 360.
  • The implant [0058] 354 (here shown to be a stent or the like) is held to the delivery guide 350 during delivery to the selected treatment site using distal brackets 364 and proximal brackets 362 or clips or the like. The proximal and distal brackets (364, 362) either include regions that cooperate with the fluid in lumen 352 to move upon application of increased pressure in that lumen 352 and release the implant 350 or move in concert with a separate pressure sensitive motion component.
  • FIG. 3E[0059] 1 shows the actuator 356 as the sealing member 358 approaches the various orifices or openings (proximal orifices 366 and distal orifices 368) communicating from the lumen 356 to the hydraulically or fluidly actuatable clips or retaining brackets (proximal brackets 362 and distal brackets 364).
  • Included in the description of this variation is a radio-[0060] opaque marker 360 on the actuator shaft 356 that allows the user to simply line up that actuator marker 360 with a corresponding radio-opaque marker 370 or the delivery guide 350, increase the pressure in lumen 352 (via syringe, pump, etc.) and deploy the proximal end 371 of implant 354. The interior pressure raises or rotates the proximal clips or brackets 362 and moves them out of contact with the implant 354. FIG. 3E2 shows the movement of the proximal end of implant 354 away from the delivery guide 350.
  • FIG. 3E[0061] 3 shows the axial movement of actuator 356 distally to a position where the sealing member 358 is positioned to actuate distal clips or brackets 364 and release the distal end of implant. Again, a radio-opaque marker 374 (perhaps with an additional identification band 376) has been depicted to show alignment of the radio-opaque marker or band 360 on the actuator shaft 356 prior to the increase in pressure for deployment.
  • FIG. 3E[0062] 4 shows final deployment at the implant 354 and proximal movement at the actuator 356, just prior to withdrawal of the delivery guide 350. The distal and proximal clips or brackets (362, 364) have relaxed to the surface of the delivery guide 350.
  • Alternatives to certain of the elements shown in the variation found in FIGS. 3E[0063] 1 to 3E4 is seen in FIGS. 3F1 and 3F2 and includes, e.g., a cover element 380 to block or cover proximal orifices 366 during the pressurization of the distal orifices 368. The cover element 380 includes holes 382 to allow fluid flow past the cover element 380.
  • FIG. 3G[0064] 1 shows a variation of the described system in which an implant or stent 371 is maintained in position on a hollow delivery guide 373 using spring clips 375 proximally and 377 distally. The spring clips hold the implant 371 in place during delivery and against guide member 373. An actuator 379 is used to remove the clips 375, 377 sequentially and to release each-end of implant 371 in an independent fashion. Clips 375 and 377, after actuation or release, remain interior to the guide member 373 for later removal with that guide member. The system shown in FIGS. 3G1, 3G2 and 3G3 may be used to deliver a number of implants in a sequential fashion. Since the retainer clips 375, 377 remain within the guide member 373 after delivery, the actuator 379 is able to slide past the site on guide member 373 where the clips 375, 377 resided prior to implant 371 deployment, down to and distally to a site on the guide member having another implant for subsequent delivery. Consequently, an arrangement such as this may be used to deploy, in a sequential fashion, a number of stents or the like without withdrawal of the guide member.
  • In the variation shown in FIGS. 3G[0065] 1, 3G2 and 3G3, the clips 375 and 377 are spring-biased to collapse within the lumen 381 of the guide member 373 once they are pushed into the respective slots 383 provided for such retraction. Such spring loaded clips retain the self expanding stent or implant 371 onto the face of guide member 373. Each of clips 375, 377 are shown in this variation to have hook members 387, 389 that engage the implant 371, often axially stretching the implant 371 and maintaining the delivery radius of the implant 371 as shown.
  • As shown in FIG. 3G[0066] 1, actuator 379 is pushed distally along the outer surface of guide member 373 until it contacts the proximal end of clip 375. Further distal movement of actuator 379 urges clip 375 into lumen 381 thereby rotating horn 387 out of cooperating receptacle area in implant 371.
  • FIG. 3G[0067] 2 shows the results of such movement after clip 375 has completed its springed closure within lumen 381. As shown in that Figure, the proximal end of implant 371 has expanded and yet the distal end of implant 371 remains closed and hooked to distal clip 377. This semi-open condition allows for some adjustment of the implant if needed. FIG. 3G3 shows the results of additional distal movement of actuator 379 until it contacts distal clip 377 (shown in FIG. 3G3 in its collapsed form ) and thereby allowing the distal end of implant 371 to self-expand into the chosen treatment site.
  • FIG. 3G[0068] 3 shows that guide member 379 is free. Implant 371 is shown in its self expanded form no longer adjacent the central guide member 379. Actuator 379 is situated within implant 371 and is no longer in contact with proximal clip 375 nor distal clip 377. Actuator 379 is thus able to continue distally to another implant containing site positioned in a more distal site on the guide member 373.
  • The mechanical variation shown in FIGS. 3G[0069] 1, 3G2, 3G3 may be modified in such a way that the actuator is interior to the lumen of the guide member and deploys the implant upon distal movement of the actuator by providing an actuator with a slot or other “room-making” provisions in the actuator. The actuator and any retained clips would then be used to actuate the clips in the next more distal implant if so desired.
  • In yet a further variation, the system releases an implant (shown as a [0070] stent 404 in FIG. 4) attached to a delivery guide 400 by one or more attachment arms 402 positioned, e.g., at the implant proximal and distal ends, by sliding a tubular member 406, mounted co-axially on the delivery guide 400, distally over the delivery guide 400. The stent 404 is secured to the delivery guide 400 when the attachment arms 402 are in a radially expanded configuration (as illustrated in FIG. 4). The tubular member 406 urges the attachment arms 402 into a compressed configuration as it slides distally over the delivery guide 400, in the direction of the arrow. When the attachment arms 402 are compressed by the tubular member 406, they are moved inward from the stent 404, toward the central axis of the delivery guide 400, thereby releasing the stent 404 from the delivery guide 400. Stent detachment occurs in a serial fashion as the tubular member 406 is moved distally, with detachment of the stent proximal end 408 occurring before detachment at the stent distal end 410. Consequently, if the stent position requires readjustment after detachment of the stent proximal end, the stent may be repositioned prior to detaching the stent distal end. In one variation, the tubular member is a balloon catheter.
  • The [0071] attachment arms 402 are generally made from the same materials as the delivery guide 400, e.g., stainless steel or nickel-titanium alloy, and will typically have a length, thickness, shape, and flexibility appropriate for its intended mechanism of release. The distal ends 412 of the attachment arms may be of any design, so long as one or more of them, when in a radially expanded configuration, secures a portion of a stent to a delivery guide, and when in a compressed configuration, releases that same stent portion from the delivery guide.
  • The tubular member may be a thin-walled tube (e.g., approximately 0.005 cm (0.002 inches) in thickness) with an outside diameter ranging from about 0.025 cm to about 0.139 cm (0.010 inches to about 0.055 inches), more usually from about 0.025 cm to about 0.05 cm (0.010 inches to about 0.020 inches), and more usually still from about 0.025 cm to about 0.035 cm (0.010 inches to about 0.014 inches). Depending on such factors as degree of flexibility or durometer required, they may be made from various metals or metal alloys, including, but not limited to, stainless steel and nickel-titanium alloy, or from various polymers, such as polyvinyl chloride, polyethylene, polyethylene terephthalate, and polyurethane. [0072]
  • FIGS. 5A, 5B, and [0073] 5C show a variation of the described delivery system 500 in which a member of electrolytic delivery joints are used to deploy an implant 502, such as a stent.
  • The electrolytic delivery joints shown here (e.g., [0074] 504 in FIG. 5C) are well known as controllable delivery joints for placement of vaso-occlusive coils. One such commercially available device using an electrolytically detachable joint is sold by Target Therapeutics, a subsidiary of Boston Scientific Corp., as the Guglielni Detachable Coil (or “GDC”). Numerous patents to Dr. Guglielmi describe the theory of its use.
  • In essence, the electrolytically erodible joint is a section of an electrical circuit that is not insulated and is of a metallic material that does not form insulating oxides when exposed to an aqueous environment (e.g., aluminum and tantalum) and is sufficiently “non-noble” that is will either electrolytically erode by ionic dissolution into an anatomical fluid or, perhaps, electrochemically erode by forming readily soluble oxides or salts. [0075]
  • The erodible joint [0076] 504 shown in FIG. 5C is a bare metal of a size, diameter, etc. that erodes away when a current is applied to insulated wire 506. The current flow is from a power supply through insulated wire 506, bare joint 504, into the ionic anatomical fluid surrounding the site to be treated, and back to a return electrode situated perhaps on the patient's skin and then back to the power supply. The current flows through the circuit so long as the joint 504 exists.
  • With that background, FIG. 5A shows a device having several joints ([0077] 504, 508, 510, 512) that each may be independently severed to controllably deploy the implant 502. Implant 502 is shown having coils (514, 516) that are terminated at each end by an erodible joint and that, prior to the severing of ajoint, hold this implant 502 to the surface of the delivery member 520. The implant 500 is self-expanding, once released. The wires forming the two coils in this variation slide within the implant or “uncoil” and thereby allow the implant body itself to expand. The coils may comprise (if electrically connected to the erodible joint) a metal that is higher in the Mendelev Electromotive Series than is the composition at the electrolytic joint or the coils may comprise a polymer that may be bio-erodible or not.
  • In any case, a suitable way to assure that the coils ([0078] 514, 516) maintain the low profile of the implant 502 during delivery is via the placement of the various conductive wires (506, 516, 518, 520) through the adjacent holes (524, 526, 528) and fill the holes with e.g., an epoxy to hold all in place. Independently causing current to flow through each of the joints will release the implant in the region of the released joint Once all joints are eroded, the implant is released.
  • Although release from proximal and distal ends of the tubular form of the implants has been described, detachment from a delivery guide is not so limited. In another variation, the stent is attached to the delivery guide at one or more positions along the length of the stent, in addition to attachment at the proximal and distal implant ends. Once the distal stent end is released, the additional attachments may be independently released until detachment at the proximal implant end releases the implant entirely from the delivery guide. Serial release may provide better control of positioning in tubular organs. [0079]
  • FIGS. 5D and 5E show in more detail, the components of an electrolytic joint (as may be found in FIGS. 5A, 5B and [0080] 5C) and another electrically actuated joint using a meltable or softenable or polymerically sizable joint.
  • FIG. 5D shows the [0081] insulated wire 524 with insulation 523 and conductor 525. The electrolytic joint 504 is also shown. In this variation, the wire 524 is shown to be secured into the delivery guide wall 520 by, e.g., an epoxy 527, an alternative or cooperative band or component 529 holding the wire 524 to the surface of guide member 520 is also shown. After erodable joint 504 is eroded, the implant of 502 expands and leaves the securement band 529 on the delivery guide 520.
  • FIG. 5E shows a similar variation but the joint comprises a thermoplastic adhesive or [0082] shape changing polymer 531 situated on the end of wire 525 and within a cup or other receptacle 533. The adhesive is of the type that changes form or viscosity upon application of current to the joint. In this variation, the thermoplastic is rendered conductive, but resistive, by introduction of material such as carbon black into the polymeric adhesive. As soon as the polymer changes its shape, form, or phase, the implant expands to the desired form about the central guide member 520 again, the wire may be held in place with an adhesive 527 if so desired.
  • Although the figures show wires and other remnants of the joints remaining exterior to the [0083] central guide member 520 and the others shown and described here, it is desirable that these not be situated in such a way that they will harm the tissues into which they are placed.
  • Delivery Method
  • The implant delivery devices described herewith may include multiple implants on a single delivery guide or may be used in conjunction with other instruments, as seen appropriate, to treat the target site. In general, the tubular organ of interest is percutaneously accessed, but the method of accessing will usually be dependent on the anatomy of the organ, medical condition being treated, health status of the subject, and the like. Consequently, access by a laparoscopic or open procedure may also be obtained. [0084]
  • FIGS. 6A-6D show the general method of deploying a stent using my described system. After obtaining access to the tubular organ of interest [0085] 600 (blood vessel in FIG. 6A), a delivery guide 602 is placed through the selected area of stenosis 604 at the target site. A balloon catheter 606 is then advanced over the delivery guide 602, and balloon angioplasty performed to dilate the area of stenosis 604 (FIG. 6B). The balloon catheter 606 is then retracted proximally and the delivery guide 602 exchanged for a stent delivery device 608 (FIG. 6C). Appropriate placement of the stent is guided by radioopaque markers 616 on the delivery guide 612. The distal end 610 of the stent is then released from the delivery guide 612. At this point, stent position may again be checked by verifying the location of the radioopaque markers. The proximal stent end 614 is then released from the delivery guide 612.
  • If desired, an embolic filter may be used during stent deployment to filter any debris generated during the procedure. The filter will usually be attached to the delivery guide such that it filters debris distal to the stent, but may also be attached to the delivery guide proximal to the stent, or both distal and proximal to the stent. The filter may be of any design, as long as it does not affect the substantially atraumatic, low profile, and controlled release characteristics of the stent delivery device. Typically, the filter is basket-shaped, and made from a shape-memory material, e.g., an alloy of titanium and nickel. The filter will usually be contained within the balloon catheter lumen, and deployed to its pre-designed shape once the balloon catheter is removed. Following placement of the stent, the balloon catheter may be advanced over the delivery guide to enclose the filter with any accumulated debris. The balloon catheter, filter, and delivery guide may then be removed from the body. [0086]
  • Applications
  • The implant delivery system may be used in mammalian subjects, preferably humans. Mammals include, but are not limited to, primates, farm animals, sport animals, cats, dogs, rabbits, mice, and rats. [0087]
  • The system may be employed for implant delivery into lumens of tubular organs including, but not limited to, blood vessels (including intracranial vessels, large vessels, peripheral vessels, aneurysms, arteriovenous malformations, arteriovenous fistulas), ureters, bile ducts, fallopian tubes, cardiac chambers, ducts such as bile ducts and mammary ducts, large and small airways, and hollow organs, e.g., stomach, intestines, and bladder. The system may also be employed for implant delivery into solid organs or tissues including, but not limited to, skin, muscle, fat, brain, liver, kidneys, spleen, and benign and malignant tumors. Preferably, the implant is delivered to a target site in a blood vessel lumen. [0088]
  • Clinically, the system may generally be used to treat stenosis of various tubular organs, arising from such etiologies as atherosclerosis, autoimmune conditions, scarring, or exterior compression, e.g., as may be seen with a neoplastic process. The system may also be used to treat medical conditions in which luminal occlusion is desired, e.g., to treat aneurysms, arteriovenous fistulas, and arteriovenous malformations. Furthermore, the system may be employed to deliver implants into such areas as joint spaces, spinal discs, and the intraperitoneal or extraperitoneal spaces. [0089]
  • All publications, patents, and patent applications cited herein are hereby incorporated by reference in their entirety for all purposes to the same extent as if each individual publication, patent, or patent application were specifically and individually indicated to be so incorporated by reference. Although the foregoing invention has been described in some detail by way of illustration and example for purposes of clarity of understanding, it will be readily apparent to those of ordinary skill in the art in light of the teachings of this invention that certain changes and modifications may be made thereto without departing from the spirit and scope of the appended claims. [0090]

Claims (57)

1.-21. (Cancelled)
22. The system of claim 24 wherein the implant exterior surface is smooth after deployment.
23. The device system of claim 24 wherein the implant interior surface is smooth after deployment.
24. A implant delivery system comprising:
an elongate delivery guide member having a proximal end and a distal end, the delivery guide member configured to direct at least one implant having an exterior and interior surface to an anatomical treatment site by manipulation by a user,
the at least one implant having a delivery diameter prior to release of the at least one implant and located proximally of the distal end of the delivery guide member prior to release,
at least one releasable joint configured to maintain at least a section of the at least one implant at the delivery diameter until release of the at least one releasable joint, and
a balloon catheter having a lumen, the delivery guide member being positioned within the lumen.
25. The system of claim 24 wherein the delivery guide member is closed at its distal end.
26. The system of claim 24 wherein the delivery guide member has a diameter distally and proximally of the at least one implant that is substantially equal to the at least one implant delivery diameter, whereby a substantially atraumatic implant delivery system is provided.
27. The system of claim 24 wherein the delivery guide member has no passageway from its proximal to its distal end.
28. The system of claim 24 further comprising an actuator for releasing the at least one releasable joint, and wherein the delivery guide member has only a single passageway from its proximal to its distal end, that passageway contains the actuator, and that actuator does not extend beyond the distal end of the delivery guide member.
29. The system of claim 28 wherein the actuator for releasing the releasable joints is affixed to the distal end of the delivery guide member.
30. The system of claim 24 wherein the at least one implant comprises exactly one implant.
31. The system of claim 24 wherein the at least one implant comprises more than one implant.
32. The system of claim 24 wherein the delivery guide member comprises a distal guide section and a proximal guide section and a gap between the distal guide section and the proximal guide section and the at least one implant is located between the distal guide section and the proximal guide section.
33. The system of claim 24 wherein the delivery guide member has a diameter distally and proximally of the at least one implant, and the at least one implant delivery diameter and delivery guide member diameters are about 0.010 inches to about 0.020 inches, whereby a low-profile delivery system is provided
34. The system of claim 24 wherein the delivery guide member is tubular in form, having a lumen therein.
35. The system of claim 34 further comprising an actuator slidably located at least partially within the delivery guide member lumen and configured to release at least one releasable joint upon axial movement within the delivery guide member.
36. The system of claim 35 wherein the actuator is configured to sequentially release more than one releasable joint upon axial movement within the delivery guide member.
37. The system of claim 35 wherein the actuator is configured to simultaneously release more than one releasable joint upon axial movement within the delivery guide member.
38. The system of claim 34 further comprising an actuator slidably located at least partially within the delivery guide member lumen and configured to release at least one releasable joint upon rotational movement within the delivery guide member.
39. The system of claim 34 wherein at least one releasable joint is configured to release upon application of fluid pressure in the delivery guide member lumen and further comprising a fluid director slidably located at least partially within the delivery guide member lumen and configured to direct fluid to and to release that selected at least one releasable joint.
40. The system of claim 39 wherein the fluid director is configured to sequentially release more than one releasable joint upon application of fluid pressure in the delivery guide member lumen.
41. The system of claim 34 wherein the at least one releasable joint is configured to release upon application of a suitable DC current to the at least one releasable joint and further comprising an electrical conductor located at least partially within the delivery guide member
42. The system of claim 41 wherein the at least one releasable joints and electrical conductors are configured to sequentially release more than one releasable joint.
43. The system of claim 41 wherein the at least one releasable joints and electrical conductors are configured to simultaneously release more than one releasable joint.
44. The system of claim 24 wherein the implant is a stent.
45. The system of claim 44 wherein the stent is unsheathed.
46. (Cancelled, without prejudice)
47. The system of claim 24 wherein the implant further comprises a therapeutic agent.
48. The system of claim 47 wherein the therapeutic agent is selected from the group consisting of antibiotics, anticoagulants, antifungal agents, anti-inflammatory agents, antineoplastic agents, antithrombotic agents, endothelialization promoting agents, free radical scavengers, immunosuppressive agents, thrombolytic agents, and combinations thereof.
49. The system of claim 24 wherein the delivery guide member further comprises a radioopaque marker.
50. The system of claim 24 having flexibility and remote directability,
wherein the remote directability is such that a user may direct the distal end of the delivery guide member into and introduce the at least one implant into a coronary artery solely by manipulation of the delivery guide member from its proximal end.
51. The system of claim 24 wherein the the system is guidewireless.
52.-75. (Cancelled)
76. A system for treating a target site in a tubular organ, the system consisting essentially of:
an elongate delivery guide member having a proximal end and a distal end, the delivery guide member configured to direct at least one implant having an exterior and interior surface to an anatomical treatment site by manipulation by a user, the at least one implant having a delivery diameter prior to release of the at least one implant and located proximally of the distal end of the delivery guide member prior to release, and at least one releasable joint configured to maintain at least a section of the at least one implant at the delivery diameter until release of the at least one releasable joint; and
a balloon catheter,
wherein the delivery guide member is adapted for receipt within a lumen of the balloon catheter.
77. A system consisting essentially of the system of claim 76 and a guidewire, wherein the guidewire is adapted for receipt within a lumen of the balloon catheter.
78. A system consisting essentially of the system of claim 76 and an embolic filter, wherein the embolic filter is attached to the proximal end of the delivery guide.
79. The system of claim 76 wherein the implant is a stent.
80. (Cancelled)
81. A method for treating a target site in a tubular organ of a subject, the method comprising:
accessing a body region;
moving an delivery guide member carrying an implant to a target site in the body region through a balloon catheter lumen;
dilating an area of stenosis at the target site with the balloon catheter; and
releasing the implant at the target site.
82. The method of claim 81 further comprising deploying at least one embolic filter.
83. The method of claim 81 wherein the releasing comprises releasing a distal end of the implant from the delivery guide member before releasing a proximal end of the implant from the delivery guide member.
84. The method of claim 81 wherein the releasing comprises a mechanical detachment process.
85. The method of claim 81 wherein the releasing comprises a hydraulic detachment process.
86. The method of claim 81 wherein the releasing comprises an electrolytic detachment process.
87. The method of claim 81 wherein the body region is a tubular or hollow organ.
88. The method of claim 87 wherein the tubular or hollow organ is selected from the group consisting of blood vessels, arteriovenous malformations, aneurysms, arteriovenous fistulas, cardiac chambers, bile ducts, mammary ducts, fallopian tubes, ureters, large and small airways, stomach, intestines, and bladder.
89. The method of claim 81 wherein the body region is a blood vessel.
90. The method of claim 81 wherein the implant is a stent.
91.-92. (Cancelled)
93. The method of claim 81 wherein the subject is human.
94. The method of claim 81 wherein the accessing is performed percutaneously.
95. The method of claim 81 wherein the stent implant delivery system is selected from those described in any of claims 22-46, 47-51 or 76-79.
96. The method of claim 81 further comprising:
advancing a guidewire to the treatment site;
advancing the balloon catheter over the guidewire to the treatment site; and
exchanging the guidewire for the delivery guide member.
97. The method of claim 81 further comprising:
retracting the balloon catheter so a distal end of the catheter is adjacent the treatment site before the releasing of the implant.
98. The method of claim 81 further comprising:
advancing the delivery guide member beyond a distal end of the balloon catheter.
99. The method of claim 98 where after the advancing of the delivery guide member, the method further comprises retracting the balloon catheter so a distal end of the catheter is adjacent the treatment site before the releasing of the implant.
100. The system of claim 24 wherein the delivery guide member is noninflatable.
101. The system of claim 25, wherein an atraumatic tip provides the end closure
US10/746,455 2003-03-26 2003-12-24 Balloon catheter lumen based stent delivery systems Abandoned US20040193179A1 (en)

Priority Applications (11)

Application Number Priority Date Filing Date Title
US10/746,455 US20040193179A1 (en) 2003-03-26 2003-12-24 Balloon catheter lumen based stent delivery systems
EP10004501A EP2226040A1 (en) 2003-03-26 2004-03-23 Stent delivery system with torsionally compressed stent
AU2004226464A AU2004226464A1 (en) 2003-03-26 2004-03-23 Implant delivery technologies
CA002517823A CA2517823A1 (en) 2003-03-26 2004-03-23 Implant delivery technologies
PCT/US2004/008909 WO2004087006A2 (en) 2003-03-26 2004-03-23 Implant delivery technologies
US10/550,707 US7785361B2 (en) 2003-03-26 2004-03-23 Implant delivery technologies
AT04758233T ATE467402T1 (en) 2003-03-26 2004-03-23 IMPLANT DEPOSIT CATHETER WITH ELECTROLYTICALLY DEGRADABLE COMPOUNDS
DE602004027122T DE602004027122D1 (en) 2003-03-26 2004-03-23 IMPLANT CATHETER WITH ELECTROLYTICALLY REMOVABLE COMPOUNDS
JP2006507500A JP2006521161A (en) 2003-03-26 2004-03-23 Implant delivery technology
EP04758233A EP1608299B1 (en) 2003-03-26 2004-03-23 Implant delivery catheter with electrolytically erodible joints
US11/266,587 US7771463B2 (en) 2003-03-26 2005-11-02 Twist-down implant delivery technologies

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US45832303P 2003-03-26 2003-03-26
US46221903P 2003-04-10 2003-04-10
US10/746,455 US20040193179A1 (en) 2003-03-26 2003-12-24 Balloon catheter lumen based stent delivery systems

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US10/792,684 Continuation-In-Part US20050209672A1 (en) 2003-03-26 2004-03-02 Sliding restraint stent delivery systems

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PCT/US2004/008909 Continuation-In-Part WO2004087006A2 (en) 2003-03-26 2004-03-23 Implant delivery technologies
US11/266,587 Continuation-In-Part US7771463B2 (en) 2003-03-26 2005-11-02 Twist-down implant delivery technologies

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US10/745,778 Expired - Fee Related US8016869B2 (en) 2003-03-26 2003-12-24 Guidewire-less stent delivery methods
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Cited By (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070073334A1 (en) * 2005-09-29 2007-03-29 Kamal Ramzipoor Combined electrolytic and mechanical separation background
US20070100416A1 (en) * 2005-11-02 2007-05-03 David Licata Covering electrolytic restraint implant delivery systems
US20070198076A1 (en) * 2006-02-13 2007-08-23 Stephen Hebert System for delivering a stent
US20070299501A1 (en) * 2002-02-28 2007-12-27 Counter Clockwise, Inc. Guidewire loaded stent for delivery through a catheter
US20090306760A1 (en) * 2008-06-06 2009-12-10 Bay Street Medical Prosthesis and delivery system
US7651521B2 (en) 2004-03-02 2010-01-26 Cardiomind, Inc. Corewire actuated delivery system with fixed distal stent-carrying extension
US7771463B2 (en) 2003-03-26 2010-08-10 Ton Dai T Twist-down implant delivery technologies
US7785361B2 (en) 2003-03-26 2010-08-31 Julian Nikolchev Implant delivery technologies
WO2010151480A3 (en) * 2009-06-26 2011-05-19 Biosensor International Group, Ltd. Implant delivery apparatus and methods with electrolytic release
US7951185B1 (en) * 2006-01-06 2011-05-31 Advanced Cardiovascular Systems, Inc. Delivery of a stent at an elevated temperature
US8016869B2 (en) 2003-03-26 2011-09-13 Biosensors International Group, Ltd. Guidewire-less stent delivery methods
US8147534B2 (en) 2005-05-25 2012-04-03 Tyco Healthcare Group Lp System and method for delivering and deploying an occluding device within a vessel
US8267985B2 (en) 2005-05-25 2012-09-18 Tyco Healthcare Group Lp System and method for delivering and deploying an occluding device within a vessel
US8273101B2 (en) 2005-05-25 2012-09-25 Tyco Healthcare Group Lp System and method for delivering and deploying an occluding device within a vessel
US8382825B2 (en) 2004-05-25 2013-02-26 Covidien Lp Flexible vascular occluding device
US8394119B2 (en) 2006-02-22 2013-03-12 Covidien Lp Stents having radiopaque mesh
US8398701B2 (en) 2004-05-25 2013-03-19 Covidien Lp Flexible vascular occluding device
US8414635B2 (en) 1999-02-01 2013-04-09 Idev Technologies, Inc. Plain woven stents
US8419788B2 (en) 2006-10-22 2013-04-16 Idev Technologies, Inc. Secured strand end devices
US20130338754A1 (en) * 2012-06-18 2013-12-19 Biotronik Ag Release device for releasing a medical implant from a catheter and catheter having a release device and implant for connection thereto and method for retaining the implant therein
US8617234B2 (en) 2004-05-25 2013-12-31 Covidien Lp Flexible vascular occluding device
US8623067B2 (en) 2004-05-25 2014-01-07 Covidien Lp Methods and apparatus for luminal stenting
US20140257455A1 (en) * 2013-03-06 2014-09-11 Cook Medical Technologies Llc Introducer sheath having a non-uniform inner surface
US8876881B2 (en) 2006-10-22 2014-11-04 Idev Technologies, Inc. Devices for stent advancement
US9023095B2 (en) 2010-05-27 2015-05-05 Idev Technologies, Inc. Stent delivery system with pusher assembly
US9114001B2 (en) 2012-10-30 2015-08-25 Covidien Lp Systems for attaining a predetermined porosity of a vascular device
US9144508B2 (en) 2007-07-19 2015-09-29 Back Bay Medical Inc. Radially expandable stent
US9155647B2 (en) 2012-07-18 2015-10-13 Covidien Lp Methods and apparatus for luminal stenting
US9157174B2 (en) 2013-02-05 2015-10-13 Covidien Lp Vascular device for aneurysm treatment and providing blood flow into a perforator vessel
US9295393B2 (en) 2012-11-09 2016-03-29 Elwha Llc Embolism deflector
US9452070B2 (en) 2012-10-31 2016-09-27 Covidien Lp Methods and systems for increasing a density of a region of a vascular device
US9675482B2 (en) 2008-05-13 2017-06-13 Covidien Lp Braid implant delivery systems
US9943427B2 (en) 2012-11-06 2018-04-17 Covidien Lp Shaped occluding devices and methods of using the same
US10004618B2 (en) 2004-05-25 2018-06-26 Covidien Lp Methods and apparatus for luminal stenting
US10729412B2 (en) 2012-02-16 2020-08-04 Biotronik Ag Release device for releasing a medical implant from a catheter and catheter having a release device and method for clamping an implant therein
US10945869B2 (en) 2017-03-09 2021-03-16 Cook Medical Technologies, LLC Low profile stent delivery system and method

Families Citing this family (97)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6176240B1 (en) 1995-06-07 2001-01-23 Conceptus, Inc. Contraceptive transcervical fallopian tube occlusion devices and their delivery
US6705323B1 (en) 1995-06-07 2004-03-16 Conceptus, Inc. Contraceptive transcervical fallopian tube occlusion devices and methods
US20070299422A1 (en) * 1999-06-21 2007-12-27 Olle Inganas Surgical device, method for operation thereof and body-implantable device
US6866679B2 (en) 2002-03-12 2005-03-15 Ev3 Inc. Everting stent and stent delivery system
US7749242B2 (en) * 2004-06-21 2010-07-06 Boston Scientific Scimed, Inc. Expanding vaso-occlusive device
EP1793744B1 (en) 2004-09-22 2008-12-17 Dendron GmbH Medical implant
US8845676B2 (en) 2004-09-22 2014-09-30 Micro Therapeutics Micro-spiral implantation device
US7666217B2 (en) * 2004-10-29 2010-02-23 Boston Scientific Scimed, Inc. Implantable medical endoprosthesis delivery systems and related components
US20070135826A1 (en) 2005-12-01 2007-06-14 Steve Zaver Method and apparatus for delivering an implant without bias to a left atrial appendage
US20070156223A1 (en) * 2005-12-30 2007-07-05 Dennis Vaughan Stent delivery system with improved delivery force distribution
US7771451B2 (en) * 2006-04-05 2010-08-10 Boston Scientific Scimed, Inc. Method and apparatus for the deployment of vaso-occlusive coils
US8777979B2 (en) 2006-04-17 2014-07-15 Covidien Lp System and method for mechanically positioning intravascular implants
KR20090008347A (en) 2006-04-17 2009-01-21 마이크로 테라퓨틱스 인코포레이티드 System and method for mechanically positioning intravascular implants
GB0700560D0 (en) * 2007-01-11 2007-02-21 Emcision Ltd Device and method for the treatment of diseased tissue such as tumours
US8133265B2 (en) * 2006-06-30 2012-03-13 Olympus Medical Systems Corp. Guide catheter, and stent delivery system
US20080051867A1 (en) * 2006-08-28 2008-02-28 Davila Luis A Multiple in vivo implant delivery device
GB2443870B (en) * 2006-11-09 2008-12-24 Motorola Inc Content item distribution
US8328860B2 (en) 2007-03-13 2012-12-11 Covidien Lp Implant including a coil and a stretch-resistant member
KR20100015521A (en) 2007-03-13 2010-02-12 마이크로 테라퓨틱스 인코포레이티드 An implant, a mandrel, and a method of forming an implant
US8092510B2 (en) * 2007-07-25 2012-01-10 Cook Medical Technologies Llc Retention wire for self-expanding stent
US7963987B2 (en) * 2007-12-28 2011-06-21 Cook Medical Technologies Llc Sequential implant delivery system
WO2009146128A1 (en) * 2008-04-03 2009-12-03 William Cook Europe Aps Implant release mechanism
EP3970633A1 (en) 2008-04-21 2022-03-23 Covidien LP Braid-ball embolic devices and delivery systems
CN102137626A (en) 2008-07-22 2011-07-27 微治疗公司 Vascular remodeling device
GB2464977B (en) * 2008-10-31 2010-11-03 William Cook Europe As Introducer for deploying a stent graft in a curved lumen and stent graft therefor
US11376114B2 (en) 2008-10-31 2022-07-05 Cook Medical Technologies Llc Introducer for deploying a stent graft in a curved lumen and stent graft therefor
US20100160951A1 (en) * 2008-12-19 2010-06-24 Madison Michael T Intracranial blood vessel dilation device
US10092427B2 (en) 2009-11-04 2018-10-09 Confluent Medical Technologies, Inc. Alternating circumferential bridge stent design and methods for use thereof
US9649211B2 (en) 2009-11-04 2017-05-16 Confluent Medical Technologies, Inc. Alternating circumferential bridge stent design and methods for use thereof
CN102740799A (en) 2010-01-28 2012-10-17 泰科保健集团有限合伙公司 Vascular remodeling device
US9301864B2 (en) 2010-06-08 2016-04-05 Veniti, Inc. Bi-directional stent delivery system
US8864811B2 (en) 2010-06-08 2014-10-21 Veniti, Inc. Bi-directional stent delivery system
US9233014B2 (en) 2010-09-24 2016-01-12 Veniti, Inc. Stent with support braces
AU2012214240B2 (en) 2011-02-11 2015-03-12 Covidien Lp Two-stage deployment aneurysm embolization devices
US20120245674A1 (en) 2011-03-25 2012-09-27 Tyco Healthcare Group Lp Vascular remodeling device
WO2013049448A1 (en) 2011-09-29 2013-04-04 Covidien Lp Vascular remodeling device
US9579104B2 (en) 2011-11-30 2017-02-28 Covidien Lp Positioning and detaching implants
US9011480B2 (en) 2012-01-20 2015-04-21 Covidien Lp Aneurysm treatment coils
CN104334117A (en) * 2012-01-26 2015-02-04 恩多沙普公司 Systems, devices, and methods for delivering a lumen occlusion device using distal and/or proximal control
US9072624B2 (en) 2012-02-23 2015-07-07 Covidien Lp Luminal stenting
US20130226278A1 (en) 2012-02-23 2013-08-29 Tyco Healthcare Group Lp Methods and apparatus for luminal stenting
DE102012102240B4 (en) * 2012-03-16 2015-11-12 Acandis Gmbh & Co. Kg Implantation system for intravascular intervention
US9687245B2 (en) 2012-03-23 2017-06-27 Covidien Lp Occlusive devices and methods of use
US9078659B2 (en) * 2012-04-23 2015-07-14 Covidien Lp Delivery system with hooks for resheathability
US9011513B2 (en) 2012-05-09 2015-04-21 Abbott Cardiovascular Systems Inc. Catheter having hydraulic actuator
US20130304180A1 (en) 2012-05-09 2013-11-14 Michael L. Green Catheter having dual balloon hydraulic actuator
US9271855B2 (en) 2012-05-09 2016-03-01 Abbott Cardiovascular Systems Inc. Catheter having hydraulic actuator with tandem chambers
US9724222B2 (en) * 2012-07-20 2017-08-08 Covidien Lp Resheathable stent delivery system
US9326774B2 (en) 2012-08-03 2016-05-03 Covidien Lp Device for implantation of medical devices
US9314248B2 (en) 2012-11-06 2016-04-19 Covidien Lp Multi-pivot thrombectomy device
US20140135907A1 (en) * 2012-11-09 2014-05-15 Medtronic CV Luxembourg S.a.r.l. Medical Device Delivery System and Methods of Delivering Medical Devices
US9622893B2 (en) 2012-12-20 2017-04-18 Cook Medical Technologies Llc Apparatus and method for improved deployment of endovascular grafts
US9295571B2 (en) 2013-01-17 2016-03-29 Covidien Lp Methods and apparatus for luminal stenting
US9119948B2 (en) * 2013-02-20 2015-09-01 Covidien Lp Occlusive implants for hollow anatomical structures, delivery systems, and related methods
US10420662B2 (en) 2013-03-12 2019-09-24 Abbott Cardiovascular Systems Inc. Catheter having movable tubular structure and proximal stopper
US9283101B2 (en) * 2013-03-12 2016-03-15 Abbott Cardiovascular Systems Inc. Catheter having hydraulic actuator and locking system
US10531971B2 (en) 2013-03-12 2020-01-14 Abbott Cardiovascular System Inc. Balloon catheter having hydraulic actuator
US9326875B2 (en) 2013-03-13 2016-05-03 Abbott Cardiovascular Systems Inc. Catheter having a movable tubular structure and method of making
US9463105B2 (en) 2013-03-14 2016-10-11 Covidien Lp Methods and apparatus for luminal stenting
CN105142545B (en) 2013-03-15 2018-04-06 柯惠有限合伙公司 Locking device
JP2014233592A (en) * 2013-06-05 2014-12-15 朝日インテック株式会社 Pusher guide wire
US10130500B2 (en) 2013-07-25 2018-11-20 Covidien Lp Methods and apparatus for luminal stenting
US8968383B1 (en) 2013-08-27 2015-03-03 Covidien Lp Delivery of medical devices
US9782186B2 (en) 2013-08-27 2017-10-10 Covidien Lp Vascular intervention system
US9713475B2 (en) 2014-04-18 2017-07-25 Covidien Lp Embolic medical devices
US9814466B2 (en) * 2014-08-08 2017-11-14 Covidien Lp Electrolytic and mechanical detachment for implant delivery systems
US9808256B2 (en) 2014-08-08 2017-11-07 Covidien Lp Electrolytic detachment elements for implant delivery systems
US9717503B2 (en) 2015-05-11 2017-08-01 Covidien Lp Electrolytic detachment for implant delivery systems
US10856877B2 (en) 2015-07-10 2020-12-08 Boston Scientific Scimed, Inc. Detachable implantable devices
US10478194B2 (en) 2015-09-23 2019-11-19 Covidien Lp Occlusive devices
WO2017066386A1 (en) * 2015-10-14 2017-04-20 Three Rivers Medical Inc. Mechanical embolization delivery apparatus and methods
US10531876B2 (en) 2016-05-31 2020-01-14 Spartan Micro, Inc. Systems and methods for delivering intravascular implants
US9968360B2 (en) * 2016-05-31 2018-05-15 Spartan Micro, Inc. Systems and methods for delivering intravascular implants
CN107041769B (en) * 2016-06-10 2019-02-01 珠海神平医疗器械有限公司 The instrument and method of mechanical plug conveying
US10828039B2 (en) 2016-06-27 2020-11-10 Covidien Lp Electrolytic detachment for implantable devices
US10828037B2 (en) 2016-06-27 2020-11-10 Covidien Lp Electrolytic detachment with fluid electrical connection
US11051822B2 (en) 2016-06-28 2021-07-06 Covidien Lp Implant detachment with thermal activation
WO2018053314A1 (en) 2016-09-16 2018-03-22 Greg Mirigian Occlusive implants with fiber-based release structures
US10702408B2 (en) 2016-10-31 2020-07-07 Cook Medical Technologies Llc Suture esophageal stent introducer
US10765545B2 (en) 2016-10-31 2020-09-08 Cook Medical Technologies Llc Suture esophageal stent introducer
US11413175B2 (en) 2016-10-31 2022-08-16 Cook Medical Technologies Llc Tube and suture stent introducer system
US11246727B2 (en) 2016-10-31 2022-02-15 Cook Medical Technologies Llc Suture esophageal stent introducer
US10500080B2 (en) * 2016-10-31 2019-12-10 Cook Medical Technologies Llc Suture esophageal stent introducer
US11141298B2 (en) 2016-10-31 2021-10-12 Cook Medical Technologies Llc Suture esophageal stent introducer
US11141299B2 (en) 2016-10-31 2021-10-12 Cook Medical Technologies Llc Suture esophageal stent introducer
US10849775B2 (en) 2016-10-31 2020-12-01 Cook Medical Technologies Llc Suture esophageal stent introducer parallel handle
US10376396B2 (en) 2017-01-19 2019-08-13 Covidien Lp Coupling units for medical device delivery systems
US10709541B2 (en) 2017-04-28 2020-07-14 Cook Medical Technologies Llc Systems and methods for adjusting the diameter of an endoluminal prosthesis and an endoluminal prosthesis configured for the same
US11471310B2 (en) * 2018-03-19 2022-10-18 SB-Kawasumi Laboratories, Inc. Indwelling device and cylindrical treatment tool
US11413176B2 (en) 2018-04-12 2022-08-16 Covidien Lp Medical device delivery
US11123209B2 (en) 2018-04-12 2021-09-21 Covidien Lp Medical device delivery
US11071637B2 (en) 2018-04-12 2021-07-27 Covidien Lp Medical device delivery
US10786377B2 (en) 2018-04-12 2020-09-29 Covidien Lp Medical device delivery
US11065140B2 (en) * 2019-01-08 2021-07-20 Covidien Lp Rotatable stent delivery apparatus to cover access site
US11413174B2 (en) 2019-06-26 2022-08-16 Covidien Lp Core assembly for medical device delivery systems
GB2605559B (en) 2021-01-07 2023-04-05 Cook Medical Technologies Llc Stent graft
WO2022266378A1 (en) * 2021-06-17 2022-12-22 Starlight Cardiovascular, Inc. Ductus arteriosus and septal conduit implants and related delivery systems and methods

Citations (92)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US843802A (en) * 1906-03-31 1907-02-12 William B Fenn Closing device for vessels.
US4503569A (en) * 1983-03-03 1985-03-12 Dotter Charles T Transluminally placed expandable graft prosthesis
US4562596A (en) * 1984-04-25 1986-01-07 Elliot Kornberg Aortic graft, device and method for performing an intraluminal abdominal aortic aneurysm repair
US4580568A (en) * 1984-10-01 1986-04-08 Cook, Incorporated Percutaneous endovascular stent and method for insertion thereof
US4655771A (en) * 1982-04-30 1987-04-07 Shepherd Patents S.A. Prosthesis comprising an expansible or contractile tubular body
US4732152A (en) * 1984-12-05 1988-03-22 Medinvent S.A. Device for implantation and a method of implantation in a vessel using such device
US4733665A (en) * 1985-11-07 1988-03-29 Expandable Grafts Partnership Expandable intraluminal graft, and method and apparatus for implanting an expandable intraluminal graft
US4893623A (en) * 1986-12-09 1990-01-16 Advanced Surgical Intervention, Inc. Method and apparatus for treating hypertrophy of the prostate gland
US4913141A (en) * 1988-10-25 1990-04-03 Cordis Corporation Apparatus and method for placement of a stent within a subject vessel
US4990151A (en) * 1988-09-28 1991-02-05 Medinvent S.A. Device for transluminal implantation or extraction
US4990155A (en) * 1989-05-19 1991-02-05 Wilkoff Howard M Surgical stent method and apparatus
US4998539A (en) * 1987-12-18 1991-03-12 Delsanti Gerard L Method of using removable endo-arterial devices to repair detachments in the arterial walls
US5089006A (en) * 1989-11-29 1992-02-18 Stiles Frank B Biological duct liner and installation catheter
US5092877A (en) * 1988-09-01 1992-03-03 Corvita Corporation Radially expandable endoprosthesis
US5102417A (en) * 1985-11-07 1992-04-07 Expandable Grafts Partnership Expandable intraluminal graft, and method and apparatus for implanting an expandable intraluminal graft
US5123917A (en) * 1990-04-27 1992-06-23 Lee Peter Y Expandable intraluminal vascular graft
US5192297A (en) * 1991-12-31 1993-03-09 Medtronic, Inc. Apparatus and method for placement and implantation of a stent
US5290305A (en) * 1991-10-11 1994-03-01 Kanji Inoue Appliance collapsible for insertion into human organs and capable of resilient restoration
US5382259A (en) * 1992-10-26 1995-01-17 Target Therapeutics, Inc. Vasoocclusion coil with attached tubular woven or braided fibrous covering
US5484444A (en) * 1992-10-31 1996-01-16 Schneider (Europe) A.G. Device for the implantation of self-expanding endoprostheses
US5486195A (en) * 1993-07-26 1996-01-23 Myers; Gene Method and apparatus for arteriotomy closure
US5591196A (en) * 1994-02-10 1997-01-07 Endovascular Systems, Inc. Method for deployment of radially expandable stents
US5601600A (en) * 1995-09-08 1997-02-11 Conceptus, Inc. Endoluminal coil delivery system having a mechanical release mechanism
US5725549A (en) * 1994-03-11 1998-03-10 Advanced Cardiovascular Systems, Inc. Coiled stent with locking ends
US5725551A (en) * 1993-07-26 1998-03-10 Myers; Gene Method and apparatus for arteriotomy closure
US5733267A (en) * 1995-04-05 1998-03-31 Scimed Life Systems, Inc. Pull back stent delivery system
US5733325A (en) * 1993-11-04 1998-03-31 C. R. Bard, Inc. Non-migrating vascular prosthesis and minimally invasive placement system
US5855578A (en) * 1990-03-13 1999-01-05 The Regents Of The University Of California Endovascular electrolytically detachable wire and tip for the formation of thrombus in arteries, veins, aneurysms, vascular malformations and arteriovenous fistulas
US5873907A (en) * 1998-01-27 1999-02-23 Endotex Interventional Systems, Inc. Electrolytic stent delivery system and methods of use
US6015429A (en) * 1994-09-08 2000-01-18 Gore Enterprise Holdings, Inc. Procedures for introducing stents and stent-grafts
US6019779A (en) * 1998-10-09 2000-02-01 Intratherapeutics Inc. Multi-filar coil medical stent
US6019737A (en) * 1997-03-31 2000-02-01 Terumo Kabushiki Kaisha Guide wire
US6019785A (en) * 1992-05-20 2000-02-01 Boston Scientific Corporation Device with a prosthesis implantable in the body of a patient
US6027516A (en) * 1995-05-04 2000-02-22 The United States Of America As Represented By The Department Of Health And Human Services Highly elastic, adjustable helical coil stent
US6027520A (en) * 1997-05-08 2000-02-22 Embol-X, Inc. Percutaneous catheter and guidewire having filter and medical device deployment capabilities
US6042589A (en) * 1998-03-17 2000-03-28 Medicorp, S.A. Reversible-action endoprosthesis delivery device
US6042605A (en) * 1995-12-14 2000-03-28 Gore Enterprose Holdings, Inc. Kink resistant stent-graft
US6042588A (en) * 1998-03-03 2000-03-28 Scimed Life Systems, Inc Stent delivery system
US6168592B1 (en) * 1996-07-26 2001-01-02 Target Therapeutics, Inc. Aneurysm closure device assembly
US6168616B1 (en) * 1997-06-02 2001-01-02 Global Vascular Concepts Manually expandable stent
US6168579B1 (en) * 1999-08-04 2001-01-02 Scimed Life Systems, Inc. Filter flush system and methods of use
US6174327B1 (en) * 1998-02-27 2001-01-16 Scimed Life Systems, Inc. Stent deployment apparatus and method
US6183481B1 (en) * 1999-09-22 2001-02-06 Endomed Inc. Delivery system for self-expanding stents and grafts
US6183505B1 (en) * 1999-03-11 2001-02-06 Medtronic Ave, Inc. Method of stent retention to a delivery catheter balloon-braided retainers
US6193708B1 (en) * 1997-08-05 2001-02-27 Scimed Life Systems, Inc. Detachable aneurysm neck bridge (I)
US6200305B1 (en) * 1998-09-30 2001-03-13 Medtronic Ave, Inc. Catheter having a variable length shaft segment and method of use
US6203550B1 (en) * 1998-09-30 2001-03-20 Medtronic, Inc. Disposable delivery device for endoluminal prostheses
US6206888B1 (en) * 1997-10-01 2001-03-27 Scimed Life Systems, Inc. Stent delivery system using shape memory retraction
US20020004676A1 (en) * 1996-12-09 2002-01-10 George Wallace Intracranial stent and method of use
US6342066B1 (en) * 1995-06-07 2002-01-29 Scimed Life Systems, Inc. Pull back sleeve system with compression resistant inner shaft
US6346118B1 (en) * 1983-12-09 2002-02-12 Endovascular Technologies, Inc. Thoracic graft and delivery catheter
US6350277B1 (en) * 1999-01-15 2002-02-26 Scimed Life Systems, Inc. Stents with temporary retaining bands
US6350278B1 (en) * 1994-06-08 2002-02-26 Medtronic Ave, Inc. Apparatus and methods for placement and repositioning of intraluminal prostheses
US20020032431A1 (en) * 1994-12-15 2002-03-14 Ferdinand Kiemeneij Catheter for percutaneous transradial approach
US20020035393A1 (en) * 1999-04-07 2002-03-21 Lashinski Robert D. Endolumenal prosthesis delivery assembly and method of use
US20020188341A1 (en) * 2001-05-10 2002-12-12 Elliott Christopher J. Stent with detachable tethers and method of using same
US20030014103A1 (en) * 1995-05-19 2003-01-16 Kanji Inoue Device for handling an appliance to be implanted
US6514285B1 (en) * 1993-03-11 2003-02-04 Medinol Ltd. Stent
US6517569B2 (en) * 1998-09-14 2003-02-11 Endocare, Inc. Insertion device for stents and methods for use
US6517548B2 (en) * 1996-08-23 2003-02-11 Scimed Life Systems, Inc. Stent delivery system
US20030036768A1 (en) * 2001-08-14 2003-02-20 Hutchins John E. Method of and apparatus for positioning and maintaining the position of endoscopic instruments
US20030040772A1 (en) * 1999-02-01 2003-02-27 Hideki Hyodoh Delivery devices
US20030045923A1 (en) * 2001-08-31 2003-03-06 Mehran Bashiri Hybrid balloon expandable/self expanding stent
US6530947B1 (en) * 1993-10-22 2003-03-11 Scimed Life Systems, Inc Stent delivery apparatus and method
US6533807B2 (en) * 1998-02-05 2003-03-18 Medtronic, Inc. Radially-expandable stent and delivery system
US6533805B1 (en) * 1996-04-01 2003-03-18 General Surgical Innovations, Inc. Prosthesis and method for deployment within a body lumen
US20030055377A1 (en) * 2000-06-02 2003-03-20 Avantec Vascular Corporation Exchangeable catheter
US6537295B2 (en) * 2001-03-06 2003-03-25 Scimed Life Systems, Inc. Wire and lock mechanism
US6676666B2 (en) * 1999-01-11 2004-01-13 Scimed Life Systems, Inc Medical device delivery system with two sheaths
US20040010265A1 (en) * 2002-05-31 2004-01-15 Wilson-Cook Medical, Inc. Stent introducer apparatus
US6679910B1 (en) * 1999-11-12 2004-01-20 Latin American Devices Llc Intraluminal stent
US20040024441A1 (en) * 2002-08-05 2004-02-05 William Bertolino Medical devices
US6689120B1 (en) * 1999-08-06 2004-02-10 Boston Scientific Scimed, Inc. Reduced profile delivery system
US6699274B2 (en) * 2001-01-22 2004-03-02 Scimed Life Systems, Inc. Stent delivery system and method of manufacturing same
US6702843B1 (en) * 2000-04-12 2004-03-09 Scimed Life Systems, Inc. Stent delivery means with balloon retraction means
US6702846B2 (en) * 1996-04-09 2004-03-09 Endocare, Inc. Urological stent therapy system and method
US20040049547A1 (en) * 2001-12-21 2004-03-11 Matthews W. Donald Methods for providing information over networks responsive to digital device user requests
US6709425B2 (en) * 1998-09-30 2004-03-23 C. R. Bard, Inc. Vascular inducing implants
US6858034B1 (en) * 1999-05-20 2005-02-22 Scimed Life Systems, Inc. Stent delivery system for prevention of kinking, and method of loading and using same
US6860899B1 (en) * 1999-04-15 2005-03-01 Boston Scientific Scimed, Inc. Method for treating neurovascular aneurysms
US20050049670A1 (en) * 2003-08-29 2005-03-03 Jones Donald K. Self-expanding stent and stent delivery system for treatment of vascular disease
US20050049668A1 (en) * 2003-08-29 2005-03-03 Jones Donald K. Self-expanding stent and stent delivery system for treatment of vascular stenosis
US20050049669A1 (en) * 2003-08-29 2005-03-03 Jones Donald K. Self-expanding stent and stent delivery system with distal protection
US6989024B2 (en) * 2002-02-28 2006-01-24 Counter Clockwise, Inc. Guidewire loaded stent for delivery through a catheter
US7004964B2 (en) * 2002-02-22 2006-02-28 Scimed Life Systems, Inc. Apparatus and method for deployment of an endoluminal device
US7011673B2 (en) * 1999-11-22 2006-03-14 Fischell Robert E Stent delivery system with a fixed guide wire
US20070027522A1 (en) * 2005-06-14 2007-02-01 Chang Jean C Stent delivery and guidewire systems
US7172620B2 (en) * 1998-04-02 2007-02-06 Salviac Limited Delivery catheter
US20070043419A1 (en) * 2003-03-26 2007-02-22 Cardiomind, Inc. Implant delivery technologies
US20070073379A1 (en) * 2005-09-29 2007-03-29 Chang Jean C Stent delivery system
US20080015541A1 (en) * 1998-05-01 2008-01-17 Rosenbluth Robert F Embolectomy Catheters And Methods For Treating Stroke And Other Small Vessel Thromboembolic Disorders
US20080071309A1 (en) * 1994-07-08 2008-03-20 Rudy Mazzocchi Method and device for filtering body fluid

Family Cites Families (230)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US625628A (en) * 1899-05-23 Combined mop and brush holder
DE3250058C2 (en) 1981-09-16 1992-08-27 Medinvent S.A., Lausanne, Ch
US4512338A (en) 1983-01-25 1985-04-23 Balko Alexander B Process for restoring patency to body vessels
US5067957A (en) 1983-10-14 1991-11-26 Raychem Corporation Method of inserting medical devices incorporating SIM alloy elements
US5190546A (en) 1983-10-14 1993-03-02 Raychem Corporation Medical devices incorporating SIM alloy elements
SE447061B (en) 1985-06-10 1986-10-27 Medinvent Sa INFO DEVICE, SPEC FOR IMPLEMENTATION IN A LIVE ORGANISM
US4665918A (en) 1986-01-06 1987-05-19 Garza Gilbert A Prosthesis system and method
EP0257091B1 (en) 1986-02-24 1993-07-28 Robert E. Fischell An intravascular stent and percutaneous insertion system
US4878906A (en) 1986-03-25 1989-11-07 Servetus Partnership Endoprosthesis for repairing a damaged vessel
SE453258B (en) 1986-04-21 1988-01-25 Medinvent Sa ELASTIC, SELF-EXPANDING PROTEST AND PROCEDURE FOR ITS MANUFACTURING
SE454482B (en) 1986-09-30 1988-05-09 Medinvent Sa DEVICE FOR IMPLANTATION
SE455834B (en) 1986-10-31 1988-08-15 Medinvent Sa DEVICE FOR TRANSLUMINAL IMPLANTATION OF A PRINCIPLE RODFORMALLY RADIALLY EXPANDABLE PROSTHESIS
US4762128A (en) 1986-12-09 1988-08-09 Advanced Surgical Intervention, Inc. Method and apparatus for treating hypertrophy of the prostate gland
JPH088933B2 (en) 1987-07-10 1996-01-31 日本ゼオン株式会社 Catheter
US5266073A (en) 1987-12-08 1993-11-30 Wall W Henry Angioplasty stent
US6071273A (en) 1988-02-29 2000-06-06 Scimed Life Systems, Inc. Fixed wire dilatation balloon catheter
US4830003A (en) 1988-06-17 1989-05-16 Wolff Rodney G Compressive stent and delivery system
US5019090A (en) * 1988-09-01 1991-05-28 Corvita Corporation Radially expandable endoprosthesis and the like
US5019085A (en) 1988-10-25 1991-05-28 Cordis Corporation Apparatus and method for placement of a stent within a subject vessel
US4950227A (en) 1988-11-07 1990-08-21 Boston Scientific Corporation Stent delivery system
EP0408245B1 (en) 1989-07-13 1994-03-02 American Medical Systems, Inc. Stent placement instrument
US5180367A (en) * 1989-09-06 1993-01-19 Datascope Corporation Procedure and balloon catheter system for relieving arterial or veinal restrictions without exchanging balloon catheters
US5035706A (en) 1989-10-17 1991-07-30 Cook Incorporated Percutaneous stent and method for retrieval thereof
US4999539A (en) * 1989-12-04 1991-03-12 Planar Systems, Inc. Electrode configuration for reducing contact density in matrix-addressed display panels
US5108416A (en) * 1990-02-13 1992-04-28 C. R. Bard, Inc. Stent introducer system
US6425893B1 (en) 1990-03-13 2002-07-30 The Regents Of The University Of California Method and apparatus for fast electrolytic detachment of an implant
US5354295A (en) 1990-03-13 1994-10-11 Target Therapeutics, Inc. In an endovascular electrolytically detachable wire and tip for the formation of thrombus in arteries, veins, aneurysms, vascular malformations and arteriovenous fistulas
US5851206A (en) 1990-03-13 1998-12-22 The Regents Of The University Of California Method and apparatus for endovascular thermal thrombosis and thermal cancer treatment
US5569245A (en) 1990-03-13 1996-10-29 The Regents Of The University Of California Detachable endovascular occlusion device activated by alternating electric current
US5122136A (en) 1990-03-13 1992-06-16 The Regents Of The University Of California Endovascular electrolytically detachable guidewire tip for the electroformation of thrombus in arteries, veins, aneurysms, vascular malformations and arteriovenous fistulas
US5221261A (en) 1990-04-12 1993-06-22 Schneider (Usa) Inc. Radially expandable fixation member
US5071407A (en) 1990-04-12 1991-12-10 Schneider (U.S.A.) Inc. Radially expandable fixation member
IL94138A (en) 1990-04-19 1997-03-18 Instent Inc Device for the treatment of constricted fluid conducting ducts
US5242399A (en) 1990-04-25 1993-09-07 Advanced Cardiovascular Systems, Inc. Method and system for stent delivery
US5158548A (en) 1990-04-25 1992-10-27 Advanced Cardiovascular Systems, Inc. Method and system for stent delivery
US5108407A (en) * 1990-06-08 1992-04-28 Rush-Presbyterian St. Luke's Medical Center Method and apparatus for placement of an embolic coil
US5064435A (en) 1990-06-28 1991-11-12 Schneider (Usa) Inc. Self-expanding prosthesis having stable axial length
DE69129487T2 (en) 1990-10-19 1999-01-07 Smith & Nephew Inc Surgical device
US5160341A (en) 1990-11-08 1992-11-03 Advanced Surgical Intervention, Inc. Resorbable urethral stent and apparatus for its insertion
US5147370A (en) 1991-06-12 1992-09-15 Mcnamara Thomas O Nitinol stent for hollow body conduits
US5242452A (en) 1991-10-11 1993-09-07 Kanji Inoue Device for collapsing an appliance collapsible for insertion into human organs
ATE157525T1 (en) 1991-10-11 1997-09-15 Angiomed Ag DEVICE FOR EXPANDING A STENOSIS
US5372600A (en) * 1991-10-31 1994-12-13 Instent Inc. Stent delivery systems
US5316023A (en) 1992-01-08 1994-05-31 Expandable Grafts Partnership Method for bilateral intra-aortic bypass
US5413560A (en) * 1992-03-30 1995-05-09 Pameda N.V. Method of rapid catheter exchange
DE69332950T2 (en) 1992-03-31 2004-05-13 Boston Scientific Corp., Natick BLOOD VESSEL FILTER
US5201757A (en) * 1992-04-03 1993-04-13 Schneider (Usa) Inc. Medial region deployment of radially self-expanding stents
US5263964A (en) 1992-05-06 1993-11-23 Coil Partners Ltd. Coaxial traction detachment apparatus and method
US5507771A (en) * 1992-06-15 1996-04-16 Cook Incorporated Stent assembly
US5772668A (en) 1992-06-18 1998-06-30 American Biomed, Inc. Apparatus for placing an endoprosthesis
US5306294A (en) 1992-08-05 1994-04-26 Ultrasonic Sensing And Monitoring Systems, Inc. Stent construction of rolled configuration
US5707376A (en) 1992-08-06 1998-01-13 William Cook Europe A/S Stent introducer and method of use
EP0607468B1 (en) 1992-12-16 1994-09-21 Schneider (Europe) Ag Stent placement instrument
WO1994015549A1 (en) 1992-12-30 1994-07-21 Schneider (Usa) Inc. Apparatus for deploying body implantable stents
CA2154784A1 (en) 1993-01-27 1994-08-04 Mordechay Beyar Vascular and coronary stents
US5360401A (en) 1993-02-18 1994-11-01 Advanced Cardiovascular Systems, Inc. Catheter for stent delivery
US5334210A (en) 1993-04-09 1994-08-02 Cook Incorporated Vascular occlusion assembly
US5800453A (en) 1993-04-19 1998-09-01 Target Therapeutics, Inc. Detachable embolic coil assembly using interlocking hooks and slots
US5772609A (en) 1993-05-11 1998-06-30 Target Therapeutics, Inc. Guidewire with variable flexibility due to polymeric coatings
US5480423A (en) 1993-05-20 1996-01-02 Boston Scientific Corporation Prosthesis delivery
ES2120489T3 (en) 1993-06-02 1998-11-01 Schneider Europ Gmbh DEVICE TO RELEASE A SELF-EXPANSIVE ENDOPROTESIS.
DE69330132T2 (en) 1993-07-23 2001-11-15 Cook Inc FLEXIBLE STENT WITH A CONFIGURATION MOLDED FROM A MATERIAL SHEET
US5445646A (en) 1993-10-22 1995-08-29 Scimed Lifesystems, Inc. Single layer hydraulic sheath stent delivery apparatus and method
US5571135A (en) 1993-10-22 1996-11-05 Scimed Life Systems Inc. Stent delivery apparatus and method
US5423829A (en) 1993-11-03 1995-06-13 Target Therapeutics, Inc. Electrolytically severable joint for endovascular embolic devices
US5476505A (en) 1993-11-18 1995-12-19 Advanced Cardiovascular Systems, Inc. Coiled stent and delivery system
JPH0737199U (en) 1993-12-24 1995-07-11 テルモ株式会社 Guide wire
US5443477A (en) 1994-02-10 1995-08-22 Stentco, Inc. Apparatus and method for deployment of radially expandable stents by a mechanical linkage
DE69534194T2 (en) 1994-03-03 2006-02-16 Boston Scientific Ltd., Barbados DEVICE FOR SEARCHING THE DIVISION IN A VASSOUCHCLUSION DEVICE
US5415664A (en) 1994-03-30 1995-05-16 Corvita Corporation Method and apparatus for introducing a stent or a stent-graft
US5554181A (en) 1994-05-04 1996-09-10 Regents Of The University Of Minnesota Stent
WO1995031945A1 (en) 1994-05-19 1995-11-30 Scimed Life Systems, Inc. Improved tissue supporting devices
US5683451A (en) 1994-06-08 1997-11-04 Cardiovascular Concepts, Inc. Apparatus and methods for deployment release of intraluminal prostheses
DE4420142C2 (en) 1994-06-09 2002-06-20 Angiomed Ag Device for expanding a stenosis
US5522836A (en) 1994-06-27 1996-06-04 Target Therapeutics, Inc. Electrolytically severable coil assembly with movable detachment point
EP0794726A4 (en) 1994-10-20 1998-01-07 Instent Inc Cystoscope delivery system
CA2163708C (en) 1994-12-07 2007-08-07 Robert E. Fischell Integrated dual-function catheter system for balloon angioplasty and stent delivery
US5578074A (en) 1994-12-22 1996-11-26 Target Therapeutics, Inc. Implant delivery method and assembly
IL116561A0 (en) 1994-12-30 1996-03-31 Target Therapeutics Inc Severable joint for detachable devices placed within the body
US5522883A (en) 1995-02-17 1996-06-04 Meadox Medicals, Inc. Endoprosthesis stent/graft deployment system
US6818014B2 (en) 1995-03-01 2004-11-16 Scimed Life Systems, Inc. Longitudinally flexible expandable stent
US5807398A (en) 1995-04-28 1998-09-15 Shaknovich; Alexander Shuttle stent delivery catheter
US6059779A (en) 1995-04-28 2000-05-09 Target Therapeutics, Inc. Delivery catheter for electrolytically detachable implant
US5534007A (en) 1995-05-18 1996-07-09 Scimed Life Systems, Inc. Stent deployment catheter with collapsible sheath
US5639274A (en) 1995-06-02 1997-06-17 Fischell; Robert E. Integrated catheter system for balloon angioplasty and stent delivery
US5989242A (en) 1995-06-26 1999-11-23 Trimedyne, Inc. Therapeutic appliance releasing device
US5776141A (en) 1995-08-28 1998-07-07 Localmed, Inc. Method and apparatus for intraluminal prosthesis delivery
US5702418A (en) * 1995-09-12 1997-12-30 Boston Scientific Corporation Stent delivery system
WO1997014375A1 (en) * 1995-10-20 1997-04-24 Bandula Wijay Vascular stent
US6428489B1 (en) 1995-12-07 2002-08-06 Precision Vascular Systems, Inc. Guidewire system
EP0950385A3 (en) 1995-12-14 1999-10-27 Prograft Medical, Inc. Stent-graft deployment apparatus and method
DK0955950T3 (en) 1996-01-04 2006-07-31 Timothy A M Dr Chuter Flat Wire Stent
US6878161B2 (en) 1996-01-05 2005-04-12 Medtronic Vascular, Inc. Stent graft loading and deployment device and method
US5690643A (en) 1996-02-20 1997-11-25 Leocor, Incorporated Stent delivery system
US5830179A (en) 1996-04-09 1998-11-03 Endocare, Inc. Urological stent therapy system and method
US6629981B2 (en) 2000-07-06 2003-10-07 Endocare, Inc. Stent delivery system
US6413269B1 (en) 2000-07-06 2002-07-02 Endocare, Inc. Stent delivery system
US5797952A (en) 1996-06-21 1998-08-25 Localmed, Inc. System and method for delivering helical stents
US6077295A (en) 1996-07-15 2000-06-20 Advanced Cardiovascular Systems, Inc. Self-expanding stent delivery system
US6096034A (en) 1996-07-26 2000-08-01 Target Therapeutics, Inc. Aneurysm closure device assembly
US5800517A (en) 1996-08-19 1998-09-01 Scimed Life Systems, Inc. Stent delivery system with storage sleeve
JP3968444B2 (en) 1996-08-23 2007-08-29 ボストン サイエンティフィック サイムド,インコーポレイテッド Stent delivery mechanism with stent fixation device
US6007543A (en) 1996-08-23 1999-12-28 Scimed Life Systems, Inc. Stent delivery system with stent securement means
US5944726A (en) 1996-08-23 1999-08-31 Scimed Life Systems, Inc. Stent delivery system having stent securement means
US5772669A (en) 1996-09-27 1998-06-30 Scimed Life Systems, Inc. Stent deployment catheter with retractable sheath
US5843090A (en) * 1996-11-05 1998-12-01 Schneider (Usa) Inc. Stent delivery device
JP2001504017A (en) 1996-11-15 2001-03-27 クック インコーポレーティッド. Separable sleeve, stent deployment device
US6395017B1 (en) 1996-11-15 2002-05-28 C. R. Bard, Inc. Endoprosthesis delivery catheter with sequential stage control
US5968052A (en) 1996-11-27 1999-10-19 Scimed Life Systems Inc. Pull back stent delivery system with pistol grip retraction handle
US5776142A (en) 1996-12-19 1998-07-07 Medtronic, Inc. Controllable stent delivery system and method
US6071286A (en) 1997-02-19 2000-06-06 Mawad; Michel E. Combination angioplasty balloon/stent deployment device
US6152944A (en) 1997-03-05 2000-11-28 Scimed Life Systems, Inc. Catheter with removable balloon protector and stent delivery system with removable stent protector
US5817101A (en) 1997-03-13 1998-10-06 Schneider (Usa) Inc Fluid actuated stent delivery system
US6048360A (en) 1997-03-18 2000-04-11 Endotex Interventional Systems, Inc. Methods of making and using coiled sheet graft for single and bifurcated lumens
US5824054A (en) 1997-03-18 1998-10-20 Endotex Interventional Systems, Inc. Coiled sheet graft stent and methods of making and use
US5824053A (en) 1997-03-18 1998-10-20 Endotex Interventional Systems, Inc. Helical mesh endoprosthesis and methods of use
US6425915B1 (en) 1997-03-18 2002-07-30 Endotex Interventional Systems, Inc. Helical mesh endoprosthesis and methods of use
US6004328A (en) 1997-06-19 1999-12-21 Solar; Ronald J. Radially expandable intraluminal stent and delivery catheter therefore and method of using the same
US6063070A (en) 1997-08-05 2000-05-16 Target Therapeutics, Inc. Detachable aneurysm neck bridge (II)
US6156061A (en) 1997-08-29 2000-12-05 Target Therapeutics, Inc. Fast-detaching electrically insulated implant
US5984929A (en) 1997-08-29 1999-11-16 Target Therapeutics, Inc. Fast detaching electronically isolated implant
DE69838256T2 (en) 1997-09-24 2008-05-15 Med Institute, Inc., West Lafayette RADIAL EXPANDABLE STENT
US5948017A (en) 1997-10-12 1999-09-07 Taheri; Syde A. Modular graft assembly
US5920975A (en) 1997-11-03 1999-07-13 Advanced Cardiovascular Systems, Inc. Stent crimping tool and method of use
US6156062A (en) 1997-12-03 2000-12-05 Ave Connaught Helically wrapped interlocking stent
US6068644A (en) * 1998-03-10 2000-05-30 Cordis Corporation Embolic coil hydraulic deployment system having improved catheter
US6425898B1 (en) 1998-03-13 2002-07-30 Cordis Corporation Delivery apparatus for a self-expanding stent
US5980485A (en) * 1998-03-13 1999-11-09 Medtronics Ave, Inc. Pressure-sensitive balloon catheter
US6558415B2 (en) 1998-03-27 2003-05-06 Intratherapeutics, Inc. Stent
US6102942A (en) 1998-03-30 2000-08-15 Endovascular Technologies, Inc. Stent/graft deployment catheter with a stent/graft attachment mechanism
US6656215B1 (en) 2000-11-16 2003-12-02 Cordis Corporation Stent graft having an improved means for attaching a stent to a graft
US6290731B1 (en) 1998-03-30 2001-09-18 Cordis Corporation Aortic graft having a precursor gasket for repairing an abdominal aortic aneurysm
US6139564A (en) 1998-06-16 2000-10-31 Target Therapeutics Inc. Minimally occlusive flow disruptor stent for bridging aneurysm necks
US5935148A (en) 1998-06-24 1999-08-10 Target Therapeutics, Inc. Detachable, varying flexibility, aneurysm neck bridge
US6117140A (en) 1998-06-26 2000-09-12 Scimed Life Systems, Inc. Stent delivery device
US20010047185A1 (en) 1998-08-22 2001-11-29 Stanley Satz Radioactivatable composition and implantable medical devices formed therefrom
US6120522A (en) 1998-08-27 2000-09-19 Scimed Life Systems, Inc. Self-expanding stent delivery catheter
US6139524A (en) 1998-10-16 2000-10-31 Scimed Life Systems, Inc. Stent delivery system with perfusion
US6059813A (en) 1998-11-06 2000-05-09 Scimed Life Systems, Inc. Rolling membrane stent delivery system
US6214036B1 (en) 1998-11-09 2001-04-10 Cordis Corporation Stent which is easily recaptured and repositioned within the body
US6063101A (en) 1998-11-20 2000-05-16 Precision Vascular Systems, Inc. Stent apparatus and method
US6113608A (en) 1998-11-20 2000-09-05 Scimed Life Systems, Inc. Stent delivery device
ATE390902T1 (en) * 1999-01-22 2008-04-15 Gore Enterprise Holdings Inc LOW PROFILE STENT AND TRANSPLANT COMBINATION
WO2000044309A2 (en) * 1999-02-01 2000-08-03 Board Of Regents, The University Of Texas System Woven bifurcated and trifurcated stents and methods for making the same
US6231597B1 (en) 1999-02-16 2001-05-15 Mark E. Deem Apparatus and methods for selectively stenting a portion of a vessel wall
EP1156758B1 (en) 1999-02-26 2008-10-15 LeMaitre Vascular, Inc. Coiled stent
US6248122B1 (en) 1999-02-26 2001-06-19 Vascular Architects, Inc. Catheter with controlled release endoluminal prosthesis
US6161029A (en) * 1999-03-08 2000-12-12 Medtronic, Inc. Apparatus and method for fixing electrodes in a blood vessel
US6221097B1 (en) 1999-03-22 2001-04-24 Scimed Life System, Inc. Lubricated sleeve material for stent delivery
US6379365B1 (en) 1999-03-29 2002-04-30 Alexis Diaz Stent delivery catheter system having grooved shaft
US6258117B1 (en) * 1999-04-15 2001-07-10 Mayo Foundation For Medical Education And Research Multi-section stent
US6607551B1 (en) 1999-05-20 2003-08-19 Scimed Life Systems, Inc. Stent delivery system with nested stabilizer
US6241758B1 (en) 1999-05-28 2001-06-05 Advanced Cardiovascular Systems, Inc. Self-expanding stent delivery system and method of use
US6280412B1 (en) 1999-06-17 2001-08-28 Scimed Life Systems, Inc. Stent securement by balloon modification
US6398802B1 (en) 1999-06-21 2002-06-04 Scimed Life Systems, Inc. Low profile delivery system for stent and graft deployment
US6632223B1 (en) 2000-03-30 2003-10-14 The General Hospital Corporation Pulmonary vein ablation stent and method
US6264671B1 (en) 1999-11-15 2001-07-24 Advanced Cardiovascular Systems, Inc. Stent delivery catheter and method of use
US6936065B2 (en) * 1999-11-22 2005-08-30 Cordis Corporation Stent delivery system having a fixed guidewire
US6375660B1 (en) 1999-11-22 2002-04-23 Cordis Corporation Stent delivery system with a fixed guide wire
US6306162B1 (en) * 1999-12-15 2001-10-23 Advanced Cardiovascular Systems, Inc. Stent delivery system utilizing novel balloon for obtaining variable post-deployment stent characteristics
US6368344B1 (en) 1999-12-16 2002-04-09 Advanced Cardiovascular Systems, Inc. Stent deployment system with reinforced inner member
US6280465B1 (en) 1999-12-30 2001-08-28 Advanced Cardiovascular Systems, Inc. Apparatus and method for delivering a self-expanding stent on a guide wire
JP2003521334A (en) 2000-02-04 2003-07-15 ウィルソン−クック メディカル インコーポレイテッド Stent introducer device
US6423090B1 (en) 2000-02-11 2002-07-23 Advanced Cardiovascular Systems, Inc. Stent pattern with staged expansion
US6432129B2 (en) 2000-02-22 2002-08-13 Scimed Life Systems, Inc. Stent delivery system
US6391050B1 (en) 2000-02-29 2002-05-21 Scimed Life Systems, Inc. Self-expanding stent delivery system
KR20020082872A (en) 2000-03-14 2002-10-31 쿡 인코포레이티드 Edovascular stent graft
US6264683B1 (en) * 2000-03-17 2001-07-24 Advanced Cardiovascular Systems, Inc. Stent delivery catheter with bumpers for improved retention of balloon expandable stents
US7201770B2 (en) 2000-03-21 2007-04-10 Cordis Corporation Everting balloon stent delivery system having tapered leading edge
US6468301B1 (en) 2000-03-27 2002-10-22 Aga Medical Corporation Repositionable and recapturable vascular stent/graft
US20020049490A1 (en) * 2000-04-11 2002-04-25 Pollock David T. Single-piece endoprosthesis with high expansion ratios
US6387118B1 (en) 2000-04-20 2002-05-14 Scimed Life Systems, Inc. Non-crimped stent delivery system
US6854467B2 (en) * 2000-05-04 2005-02-15 Percardia, Inc. Methods and devices for delivering a ventricular stent
DE10026307A1 (en) 2000-05-26 2001-11-29 Variomed Ag Balzers Stent, positioning element and insertion catheter
US6875212B2 (en) * 2000-06-23 2005-04-05 Vertelink Corporation Curable media for implantable medical device
US20020077693A1 (en) 2000-12-19 2002-06-20 Barclay Bruce J. Covered, coiled drug delivery stent and method
US6679879B2 (en) * 2000-08-16 2004-01-20 John H. Shadduck Electrical discharge catheter system for extracting emboli in endovascular interventions
US6837897B2 (en) * 2000-10-06 2005-01-04 Scimed Life Systems, Inc. Lumen support for welding
US6602226B1 (en) 2000-10-12 2003-08-05 Scimed Life Systems, Inc. Low-profile stent delivery system and apparatus
AU2002213231A1 (en) 2000-10-18 2002-04-29 Nmt Medical, Inc. Over-the-wire interlock attachment/detachment mechanism
US6663664B1 (en) 2000-10-26 2003-12-16 Advanced Cardiovascular Systems, Inc. Self-expanding stent with time variable radial force
US6562064B1 (en) 2000-10-27 2003-05-13 Vascular Architects, Inc. Placement catheter assembly
US6428566B1 (en) 2000-10-31 2002-08-06 Advanced Cardiovascular Systems, Inc. Flexible hoop and link sheath for a stent delivery system
US6602272B2 (en) 2000-11-02 2003-08-05 Advanced Cardiovascular Systems, Inc. Devices configured from heat shaped, strain hardened nickel-titanium
US6843802B1 (en) * 2000-11-16 2005-01-18 Cordis Corporation Delivery apparatus for a self expanding retractable stent
US6582460B1 (en) 2000-11-20 2003-06-24 Advanced Cardiovascular Systems, Inc. System and method for accurately deploying a stent
US6579308B1 (en) 2000-11-28 2003-06-17 Scimed Life Systems, Inc. Stent devices with detachable distal or proximal wires
US6562022B2 (en) 2000-12-13 2003-05-13 Advanced Cardiovascular Systems, Inc. Catheter with enhanced reinforcement
US6468298B1 (en) 2000-12-28 2002-10-22 Advanced Cardiovascular Systems, Inc. Gripping delivery system for self-expanding stents and method of using the same
US6579300B2 (en) * 2001-01-18 2003-06-17 Scimed Life Systems, Inc. Steerable sphincterotome and methods for cannulation, papillotomy and sphincterotomy
US6736839B2 (en) * 2001-02-01 2004-05-18 Charles Cummings Medical device delivery system
US6623518B2 (en) 2001-02-26 2003-09-23 Ev3 Peripheral, Inc. Implant delivery system with interlock
US7294137B2 (en) 2001-03-27 2007-11-13 Boston Scientific Scimed Device for multi-modal treatment of vascular lesions
US6660031B2 (en) 2001-04-11 2003-12-09 Scimed Life Systems, Inc. Multi-length delivery system
US6911038B2 (en) * 2001-05-08 2005-06-28 Scimed Life Systems, Inc. Matched balloon to stent shortening
US6607539B1 (en) 2001-05-18 2003-08-19 Endovascular Technologies, Inc. Electric endovascular implant depolyment system
US6821291B2 (en) 2001-06-01 2004-11-23 Ams Research Corporation Retrievable stent and method of use thereof
US6645238B2 (en) 2001-07-09 2003-11-11 Scimed Life Systems, Inc. Skids stent delivery system
US6726714B2 (en) * 2001-08-09 2004-04-27 Scimed Life Systems, Inc. Stent delivery system
US6752825B2 (en) * 2001-10-02 2004-06-22 Scimed Life Systems, Inc Nested stent apparatus
US6918882B2 (en) 2001-10-05 2005-07-19 Scimed Life Systems, Inc. Guidewire with stiffness blending connection
US7594926B2 (en) 2001-11-09 2009-09-29 Boston Scientific Scimed, Inc. Methods, systems and devices for delivering stents
US20030135266A1 (en) 2001-12-03 2003-07-17 Xtent, Inc. Apparatus and methods for delivery of multiple distributed stents
US6830575B2 (en) 2002-05-08 2004-12-14 Scimed Life Systems, Inc. Method and device for providing full protection to a stent
US7264632B2 (en) 2002-06-07 2007-09-04 Medtronic Vascular, Inc. Controlled deployment delivery system
US6833003B2 (en) 2002-06-24 2004-12-21 Cordis Neurovascular Expandable stent and delivery system
US6814746B2 (en) * 2002-11-01 2004-11-09 Ev3 Peripheral, Inc. Implant delivery system with marker interlock
US6849084B2 (en) 2002-12-31 2005-02-01 Intek Technology L.L.C. Stent delivery system
US7300460B2 (en) 2002-12-31 2007-11-27 Counter Clockwise, Inc. Bifurcated guidewire and methods of use
US20050049672A1 (en) * 2003-03-24 2005-03-03 Murphy Kieran P. Stent delivery system and method using a balloon for a self-expandable stent
US20040193246A1 (en) 2003-03-25 2004-09-30 Microvention, Inc. Methods and apparatus for treating aneurysms and other vascular defects
US7771463B2 (en) 2003-03-26 2010-08-10 Ton Dai T Twist-down implant delivery technologies
US20040193178A1 (en) 2003-03-26 2004-09-30 Cardiomind, Inc. Multiple joint implant delivery systems for sequentially-controlled implant deployment
US20050209672A1 (en) 2004-03-02 2005-09-22 Cardiomind, Inc. Sliding restraint stent delivery systems
US20040260377A1 (en) 2003-06-17 2004-12-23 Medinol, Ltd. Shape memory alloy endoprosthesis delivery system
US7963952B2 (en) * 2003-08-19 2011-06-21 Wright Jr John A Expandable sheath tubing
US7651521B2 (en) 2004-03-02 2010-01-26 Cardiomind, Inc. Corewire actuated delivery system with fixed distal stent-carrying extension
US20050209671A1 (en) 2004-03-02 2005-09-22 Cardiomind, Inc. Corewire actuated delivery system with fixed distal stent-carrying extension
US20050209670A1 (en) 2004-03-02 2005-09-22 Cardiomind, Inc. Stent delivery system with diameter adaptive restraint
US20050220836A1 (en) 2004-03-31 2005-10-06 Robert Falotico Drug delivery device
US7766960B2 (en) 2004-04-30 2010-08-03 Novostent Corporation Delivery catheter that controls foreshortening of ribbon-type prostheses and methods of making and use
WO2006044147A2 (en) 2004-10-14 2006-04-27 Cardiomind, Inc. Small vessel stent designs
US20060085057A1 (en) 2004-10-14 2006-04-20 Cardiomind Delivery guide member based stent anti-jumping technologies
US8348858B2 (en) 2005-01-05 2013-01-08 Stereotaxis, Inc. Stent delivery guide wire
US20060190070A1 (en) 2005-02-23 2006-08-24 Dieck Martin S Rail stent and methods of use
KR20080002984A (en) 2005-04-20 2008-01-04 쿡 인코포레이티드 Medical apparatus for rapid insertion
US20060271097A1 (en) 2005-05-31 2006-11-30 Kamal Ramzipoor Electrolytically detachable implantable devices
US20060276886A1 (en) 2005-06-07 2006-12-07 Cardiomind, Inc. Ten-thousandths scale metal reinforced stent delivery guide sheath or restraint
US20070100414A1 (en) 2005-11-02 2007-05-03 Cardiomind, Inc. Indirect-release electrolytic implant delivery systems
CN101605509B (en) 2006-12-15 2012-09-19 生物传感器国际集团有限公司 Stent systems

Patent Citations (104)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US843802A (en) * 1906-03-31 1907-02-12 William B Fenn Closing device for vessels.
US4655771A (en) * 1982-04-30 1987-04-07 Shepherd Patents S.A. Prosthesis comprising an expansible or contractile tubular body
US4655771B1 (en) * 1982-04-30 1996-09-10 Medinvent Ams Sa Prosthesis comprising an expansible or contractile tubular body
US4503569A (en) * 1983-03-03 1985-03-12 Dotter Charles T Transluminally placed expandable graft prosthesis
US6346118B1 (en) * 1983-12-09 2002-02-12 Endovascular Technologies, Inc. Thoracic graft and delivery catheter
US4562596A (en) * 1984-04-25 1986-01-07 Elliot Kornberg Aortic graft, device and method for performing an intraluminal abdominal aortic aneurysm repair
US4580568A (en) * 1984-10-01 1986-04-08 Cook, Incorporated Percutaneous endovascular stent and method for insertion thereof
US4732152A (en) * 1984-12-05 1988-03-22 Medinvent S.A. Device for implantation and a method of implantation in a vessel using such device
US4733665C2 (en) * 1985-11-07 2002-01-29 Expandable Grafts Partnership Expandable intraluminal graft and method and apparatus for implanting an expandable intraluminal graft
US4733665A (en) * 1985-11-07 1988-03-29 Expandable Grafts Partnership Expandable intraluminal graft, and method and apparatus for implanting an expandable intraluminal graft
US5102417A (en) * 1985-11-07 1992-04-07 Expandable Grafts Partnership Expandable intraluminal graft, and method and apparatus for implanting an expandable intraluminal graft
US4733665B1 (en) * 1985-11-07 1994-01-11 Expandable Grafts Partnership Expandable intraluminal graft,and method and apparatus for implanting an expandable intraluminal graft
US4893623A (en) * 1986-12-09 1990-01-16 Advanced Surgical Intervention, Inc. Method and apparatus for treating hypertrophy of the prostate gland
US4998539A (en) * 1987-12-18 1991-03-12 Delsanti Gerard L Method of using removable endo-arterial devices to repair detachments in the arterial walls
US5092877A (en) * 1988-09-01 1992-03-03 Corvita Corporation Radially expandable endoprosthesis
US4990151A (en) * 1988-09-28 1991-02-05 Medinvent S.A. Device for transluminal implantation or extraction
US4913141A (en) * 1988-10-25 1990-04-03 Cordis Corporation Apparatus and method for placement of a stent within a subject vessel
US4990155A (en) * 1989-05-19 1991-02-05 Wilkoff Howard M Surgical stent method and apparatus
US5089006A (en) * 1989-11-29 1992-02-18 Stiles Frank B Biological duct liner and installation catheter
US5855578A (en) * 1990-03-13 1999-01-05 The Regents Of The University Of California Endovascular electrolytically detachable wire and tip for the formation of thrombus in arteries, veins, aneurysms, vascular malformations and arteriovenous fistulas
US5123917A (en) * 1990-04-27 1992-06-23 Lee Peter Y Expandable intraluminal vascular graft
US5290305A (en) * 1991-10-11 1994-03-01 Kanji Inoue Appliance collapsible for insertion into human organs and capable of resilient restoration
US5192297A (en) * 1991-12-31 1993-03-09 Medtronic, Inc. Apparatus and method for placement and implantation of a stent
US20020007208A1 (en) * 1992-05-20 2002-01-17 Boston Scientific Corporation Device with a prosthesis implantable in the body of a patient
US6019785A (en) * 1992-05-20 2000-02-01 Boston Scientific Corporation Device with a prosthesis implantable in the body of a patient
US5382259A (en) * 1992-10-26 1995-01-17 Target Therapeutics, Inc. Vasoocclusion coil with attached tubular woven or braided fibrous covering
US5484444A (en) * 1992-10-31 1996-01-16 Schneider (Europe) A.G. Device for the implantation of self-expanding endoprostheses
US6514285B1 (en) * 1993-03-11 2003-02-04 Medinol Ltd. Stent
US6692521B2 (en) * 1993-03-11 2004-02-17 Medinol Ltd. Stent
US5486195A (en) * 1993-07-26 1996-01-23 Myers; Gene Method and apparatus for arteriotomy closure
US5725551A (en) * 1993-07-26 1998-03-10 Myers; Gene Method and apparatus for arteriotomy closure
US6530947B1 (en) * 1993-10-22 2003-03-11 Scimed Life Systems, Inc Stent delivery apparatus and method
US5733325A (en) * 1993-11-04 1998-03-31 C. R. Bard, Inc. Non-migrating vascular prosthesis and minimally invasive placement system
US5591196A (en) * 1994-02-10 1997-01-07 Endovascular Systems, Inc. Method for deployment of radially expandable stents
US5725549A (en) * 1994-03-11 1998-03-10 Advanced Cardiovascular Systems, Inc. Coiled stent with locking ends
US6350278B1 (en) * 1994-06-08 2002-02-26 Medtronic Ave, Inc. Apparatus and methods for placement and repositioning of intraluminal prostheses
US20080071309A1 (en) * 1994-07-08 2008-03-20 Rudy Mazzocchi Method and device for filtering body fluid
US6015429A (en) * 1994-09-08 2000-01-18 Gore Enterprise Holdings, Inc. Procedures for introducing stents and stent-grafts
US20030018319A1 (en) * 1994-12-15 2003-01-23 Schneider (Europe) A.G. Catheter for percutaneous transradial approach
US20020032431A1 (en) * 1994-12-15 2002-03-14 Ferdinand Kiemeneij Catheter for percutaneous transradial approach
US5733267A (en) * 1995-04-05 1998-03-31 Scimed Life Systems, Inc. Pull back stent delivery system
US6027516A (en) * 1995-05-04 2000-02-22 The United States Of America As Represented By The Department Of Health And Human Services Highly elastic, adjustable helical coil stent
US20030014103A1 (en) * 1995-05-19 2003-01-16 Kanji Inoue Device for handling an appliance to be implanted
US6342066B1 (en) * 1995-06-07 2002-01-29 Scimed Life Systems, Inc. Pull back sleeve system with compression resistant inner shaft
US5601600A (en) * 1995-09-08 1997-02-11 Conceptus, Inc. Endoluminal coil delivery system having a mechanical release mechanism
US20020002397A1 (en) * 1995-12-14 2002-01-03 Martin Gerald Ray Kink resistant stent-graft
US6042605A (en) * 1995-12-14 2000-03-28 Gore Enterprose Holdings, Inc. Kink resistant stent-graft
US6520986B2 (en) * 1995-12-14 2003-02-18 Gore Enterprise Holdings, Inc. Kink resistant stent-graft
US6361637B2 (en) * 1995-12-14 2002-03-26 Gore Enterprise Holdings, Inc. Method of making a kink resistant stent-graft
US6533805B1 (en) * 1996-04-01 2003-03-18 General Surgical Innovations, Inc. Prosthesis and method for deployment within a body lumen
US6702846B2 (en) * 1996-04-09 2004-03-09 Endocare, Inc. Urological stent therapy system and method
US6168592B1 (en) * 1996-07-26 2001-01-02 Target Therapeutics, Inc. Aneurysm closure device assembly
US6344041B1 (en) * 1996-07-26 2002-02-05 David Kupiecki Aneurysm closure device assembly
US6517548B2 (en) * 1996-08-23 2003-02-11 Scimed Life Systems, Inc. Stent delivery system
US20020004676A1 (en) * 1996-12-09 2002-01-10 George Wallace Intracranial stent and method of use
US6019737A (en) * 1997-03-31 2000-02-01 Terumo Kabushiki Kaisha Guide wire
US6027520A (en) * 1997-05-08 2000-02-22 Embol-X, Inc. Percutaneous catheter and guidewire having filter and medical device deployment capabilities
US6168616B1 (en) * 1997-06-02 2001-01-02 Global Vascular Concepts Manually expandable stent
US6193708B1 (en) * 1997-08-05 2001-02-27 Scimed Life Systems, Inc. Detachable aneurysm neck bridge (I)
US6206888B1 (en) * 1997-10-01 2001-03-27 Scimed Life Systems, Inc. Stent delivery system using shape memory retraction
US6168618B1 (en) * 1998-01-27 2001-01-02 Endotex Interventional Systems, Inc. Electrolytic stent delivery system and methods of use
US5873907A (en) * 1998-01-27 1999-02-23 Endotex Interventional Systems, Inc. Electrolytic stent delivery system and methods of use
US6533807B2 (en) * 1998-02-05 2003-03-18 Medtronic, Inc. Radially-expandable stent and delivery system
US6174327B1 (en) * 1998-02-27 2001-01-16 Scimed Life Systems, Inc. Stent deployment apparatus and method
US6042588A (en) * 1998-03-03 2000-03-28 Scimed Life Systems, Inc Stent delivery system
US6042589A (en) * 1998-03-17 2000-03-28 Medicorp, S.A. Reversible-action endoprosthesis delivery device
US7172620B2 (en) * 1998-04-02 2007-02-06 Salviac Limited Delivery catheter
US20080015541A1 (en) * 1998-05-01 2008-01-17 Rosenbluth Robert F Embolectomy Catheters And Methods For Treating Stroke And Other Small Vessel Thromboembolic Disorders
US6517569B2 (en) * 1998-09-14 2003-02-11 Endocare, Inc. Insertion device for stents and methods for use
US6709425B2 (en) * 1998-09-30 2004-03-23 C. R. Bard, Inc. Vascular inducing implants
US6200305B1 (en) * 1998-09-30 2001-03-13 Medtronic Ave, Inc. Catheter having a variable length shaft segment and method of use
US6203550B1 (en) * 1998-09-30 2001-03-20 Medtronic, Inc. Disposable delivery device for endoluminal prostheses
US6019779A (en) * 1998-10-09 2000-02-01 Intratherapeutics Inc. Multi-filar coil medical stent
US6676666B2 (en) * 1999-01-11 2004-01-13 Scimed Life Systems, Inc Medical device delivery system with two sheaths
US6350277B1 (en) * 1999-01-15 2002-02-26 Scimed Life Systems, Inc. Stents with temporary retaining bands
US20030040772A1 (en) * 1999-02-01 2003-02-27 Hideki Hyodoh Delivery devices
US20030040771A1 (en) * 1999-02-01 2003-02-27 Hideki Hyodoh Methods for creating woven devices
US6183505B1 (en) * 1999-03-11 2001-02-06 Medtronic Ave, Inc. Method of stent retention to a delivery catheter balloon-braided retainers
US20020035393A1 (en) * 1999-04-07 2002-03-21 Lashinski Robert D. Endolumenal prosthesis delivery assembly and method of use
US6860899B1 (en) * 1999-04-15 2005-03-01 Boston Scientific Scimed, Inc. Method for treating neurovascular aneurysms
US6858034B1 (en) * 1999-05-20 2005-02-22 Scimed Life Systems, Inc. Stent delivery system for prevention of kinking, and method of loading and using same
US6168579B1 (en) * 1999-08-04 2001-01-02 Scimed Life Systems, Inc. Filter flush system and methods of use
US6689120B1 (en) * 1999-08-06 2004-02-10 Boston Scientific Scimed, Inc. Reduced profile delivery system
US6183481B1 (en) * 1999-09-22 2001-02-06 Endomed Inc. Delivery system for self-expanding stents and grafts
US6679910B1 (en) * 1999-11-12 2004-01-20 Latin American Devices Llc Intraluminal stent
US7011673B2 (en) * 1999-11-22 2006-03-14 Fischell Robert E Stent delivery system with a fixed guide wire
US6702843B1 (en) * 2000-04-12 2004-03-09 Scimed Life Systems, Inc. Stent delivery means with balloon retraction means
US20030055377A1 (en) * 2000-06-02 2003-03-20 Avantec Vascular Corporation Exchangeable catheter
US6699274B2 (en) * 2001-01-22 2004-03-02 Scimed Life Systems, Inc. Stent delivery system and method of manufacturing same
US6537295B2 (en) * 2001-03-06 2003-03-25 Scimed Life Systems, Inc. Wire and lock mechanism
US20020188341A1 (en) * 2001-05-10 2002-12-12 Elliott Christopher J. Stent with detachable tethers and method of using same
US20030036768A1 (en) * 2001-08-14 2003-02-20 Hutchins John E. Method of and apparatus for positioning and maintaining the position of endoscopic instruments
US20030045923A1 (en) * 2001-08-31 2003-03-06 Mehran Bashiri Hybrid balloon expandable/self expanding stent
US20040049547A1 (en) * 2001-12-21 2004-03-11 Matthews W. Donald Methods for providing information over networks responsive to digital device user requests
US7004964B2 (en) * 2002-02-22 2006-02-28 Scimed Life Systems, Inc. Apparatus and method for deployment of an endoluminal device
US6989024B2 (en) * 2002-02-28 2006-01-24 Counter Clockwise, Inc. Guidewire loaded stent for delivery through a catheter
US20040010265A1 (en) * 2002-05-31 2004-01-15 Wilson-Cook Medical, Inc. Stent introducer apparatus
US20040024441A1 (en) * 2002-08-05 2004-02-05 William Bertolino Medical devices
US20070043419A1 (en) * 2003-03-26 2007-02-22 Cardiomind, Inc. Implant delivery technologies
US20050049668A1 (en) * 2003-08-29 2005-03-03 Jones Donald K. Self-expanding stent and stent delivery system for treatment of vascular stenosis
US20050049669A1 (en) * 2003-08-29 2005-03-03 Jones Donald K. Self-expanding stent and stent delivery system with distal protection
US20050049670A1 (en) * 2003-08-29 2005-03-03 Jones Donald K. Self-expanding stent and stent delivery system for treatment of vascular disease
US20070027522A1 (en) * 2005-06-14 2007-02-01 Chang Jean C Stent delivery and guidewire systems
US20070073379A1 (en) * 2005-09-29 2007-03-29 Chang Jean C Stent delivery system

Cited By (94)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9925074B2 (en) 1999-02-01 2018-03-27 Board Of Regents, The University Of Texas System Plain woven stents
US8974516B2 (en) 1999-02-01 2015-03-10 Board Of Regents, The University Of Texas System Plain woven stents
US8876880B2 (en) 1999-02-01 2014-11-04 Board Of Regents, The University Of Texas System Plain woven stents
US8414635B2 (en) 1999-02-01 2013-04-09 Idev Technologies, Inc. Plain woven stents
US9114038B2 (en) 2002-02-28 2015-08-25 Back Bay Medical Inc. Method of delivering a stent
US20070299501A1 (en) * 2002-02-28 2007-12-27 Counter Clockwise, Inc. Guidewire loaded stent for delivery through a catheter
US8696728B2 (en) 2002-02-28 2014-04-15 Bay Street Medical, Inc. Guidewire loaded stent for delivery through a catheter
US8641748B2 (en) 2002-02-28 2014-02-04 Bay Street Medical, Inc. Guidewire loaded stent for delivery through a catheter
US8016869B2 (en) 2003-03-26 2011-09-13 Biosensors International Group, Ltd. Guidewire-less stent delivery methods
US7771463B2 (en) 2003-03-26 2010-08-10 Ton Dai T Twist-down implant delivery technologies
US7785361B2 (en) 2003-03-26 2010-08-31 Julian Nikolchev Implant delivery technologies
US7651521B2 (en) 2004-03-02 2010-01-26 Cardiomind, Inc. Corewire actuated delivery system with fixed distal stent-carrying extension
US9050205B2 (en) 2004-05-25 2015-06-09 Covidien Lp Methods and apparatus for luminal stenting
US8617234B2 (en) 2004-05-25 2013-12-31 Covidien Lp Flexible vascular occluding device
US9855047B2 (en) 2004-05-25 2018-01-02 Covidien Lp Flexible vascular occluding device
US9801744B2 (en) 2004-05-25 2017-10-31 Covidien Lp Methods and apparatus for luminal stenting
US9393021B2 (en) 2004-05-25 2016-07-19 Covidien Lp Flexible vascular occluding device
US10004618B2 (en) 2004-05-25 2018-06-26 Covidien Lp Methods and apparatus for luminal stenting
US10765542B2 (en) 2004-05-25 2020-09-08 Covidien Lp Methods and apparatus for luminal stenting
US9295568B2 (en) 2004-05-25 2016-03-29 Covidien Lp Methods and apparatus for luminal stenting
US10918389B2 (en) 2004-05-25 2021-02-16 Covidien Lp Flexible vascular occluding device
US8382825B2 (en) 2004-05-25 2013-02-26 Covidien Lp Flexible vascular occluding device
US9125659B2 (en) 2004-05-25 2015-09-08 Covidien Lp Flexible vascular occluding device
US8398701B2 (en) 2004-05-25 2013-03-19 Covidien Lp Flexible vascular occluding device
US11771433B2 (en) 2004-05-25 2023-10-03 Covidien Lp Flexible vascular occluding device
US8628564B2 (en) 2004-05-25 2014-01-14 Covidien Lp Methods and apparatus for luminal stenting
US8623067B2 (en) 2004-05-25 2014-01-07 Covidien Lp Methods and apparatus for luminal stenting
US9381104B2 (en) 2005-05-25 2016-07-05 Covidien Lp System and method for delivering and deploying an occluding device within a vessel
US9198666B2 (en) 2005-05-25 2015-12-01 Covidien Lp System and method for delivering and deploying an occluding device within a vessel
US9204983B2 (en) 2005-05-25 2015-12-08 Covidien Lp System and method for delivering and deploying an occluding device within a vessel
US10064747B2 (en) 2005-05-25 2018-09-04 Covidien Lp System and method for delivering and deploying an occluding device within a vessel
US8273101B2 (en) 2005-05-25 2012-09-25 Tyco Healthcare Group Lp System and method for delivering and deploying an occluding device within a vessel
US10322018B2 (en) 2005-05-25 2019-06-18 Covidien Lp System and method for delivering and deploying an occluding device within a vessel
US9095343B2 (en) 2005-05-25 2015-08-04 Covidien Lp System and method for delivering and deploying an occluding device within a vessel
US8147534B2 (en) 2005-05-25 2012-04-03 Tyco Healthcare Group Lp System and method for delivering and deploying an occluding device within a vessel
US8236042B2 (en) 2005-05-25 2012-08-07 Tyco Healthcare Group Lp System and method for delivering and deploying an occluding device within a vessel
US8257421B2 (en) 2005-05-25 2012-09-04 Tyco Healthcare Group Lp System and method for delivering and deploying an occluding device within a vessel
US8267985B2 (en) 2005-05-25 2012-09-18 Tyco Healthcare Group Lp System and method for delivering and deploying an occluding device within a vessel
WO2007041407A1 (en) * 2005-09-29 2007-04-12 Boston Scientific Limited Combined electrolytic and mechanical separation background
US20070073334A1 (en) * 2005-09-29 2007-03-29 Kamal Ramzipoor Combined electrolytic and mechanical separation background
US8900285B2 (en) * 2005-11-02 2014-12-02 Biosensors International Group, Ltd. Covering electrolytic restraint implant delivery systems
US20070100416A1 (en) * 2005-11-02 2007-05-03 David Licata Covering electrolytic restraint implant delivery systems
US8974509B2 (en) * 2005-11-02 2015-03-10 Biosensors International Group, Ltd. Pass-through restraint electrolytic implant delivery systems
US8579954B2 (en) 2005-11-02 2013-11-12 Biosensors International Group, Ltd. Untwisting restraint implant delivery system
US8273116B2 (en) 2005-11-02 2012-09-25 Biosensors International Group, Ltd. Indirect-release electrolytic implant delivery systems
US7862602B2 (en) 2005-11-02 2011-01-04 Biosensors International Group, Ltd Indirect-release electrolytic implant delivery systems
US8277498B2 (en) 2006-01-06 2012-10-02 Advanced Cardiovascular Systems, Inc. System for delivery of a stent at an elevated temperature
US7951185B1 (en) * 2006-01-06 2011-05-31 Advanced Cardiovascular Systems, Inc. Delivery of a stent at an elevated temperature
US20070198076A1 (en) * 2006-02-13 2007-08-23 Stephen Hebert System for delivering a stent
US10433988B2 (en) 2006-02-22 2019-10-08 Covidien Lp Stents having radiopaque mesh
US9320590B2 (en) 2006-02-22 2016-04-26 Covidien Lp Stents having radiopaque mesh
US9610181B2 (en) 2006-02-22 2017-04-04 Covidien Lp Stents having radiopaque mesh
US8394119B2 (en) 2006-02-22 2013-03-12 Covidien Lp Stents having radiopaque mesh
US11382777B2 (en) 2006-02-22 2022-07-12 Covidien Lp Stents having radiopaque mesh
US8966733B2 (en) 2006-10-22 2015-03-03 Idev Technologies, Inc. Secured strand end devices
US10470902B2 (en) 2006-10-22 2019-11-12 Idev Technologies, Inc. Secured strand end devices
US8419788B2 (en) 2006-10-22 2013-04-16 Idev Technologies, Inc. Secured strand end devices
US9895242B2 (en) 2006-10-22 2018-02-20 Idev Technologies, Inc. Secured strand end devices
US8739382B2 (en) 2006-10-22 2014-06-03 Idev Technologies, Inc. Secured strand end devices
US9149374B2 (en) 2006-10-22 2015-10-06 Idev Technologies, Inc. Methods for manufacturing secured strand end devices
US9629736B2 (en) 2006-10-22 2017-04-25 Idev Technologies, Inc. Secured strand end devices
US9408730B2 (en) 2006-10-22 2016-08-09 Idev Technologies, Inc. Secured strand end devices
US9408729B2 (en) 2006-10-22 2016-08-09 Idev Technologies, Inc. Secured strand end devices
US8876881B2 (en) 2006-10-22 2014-11-04 Idev Technologies, Inc. Devices for stent advancement
US9585776B2 (en) 2006-10-22 2017-03-07 Idev Technologies, Inc. Secured strand end devices
US9144508B2 (en) 2007-07-19 2015-09-29 Back Bay Medical Inc. Radially expandable stent
US9675482B2 (en) 2008-05-13 2017-06-13 Covidien Lp Braid implant delivery systems
US10610389B2 (en) 2008-05-13 2020-04-07 Covidien Lp Braid implant delivery systems
US11707371B2 (en) 2008-05-13 2023-07-25 Covidien Lp Braid implant delivery systems
US20090306760A1 (en) * 2008-06-06 2009-12-10 Bay Street Medical Prosthesis and delivery system
US8876876B2 (en) 2008-06-06 2014-11-04 Back Bay Medical Inc. Prosthesis and delivery system
US20090306761A1 (en) * 2008-06-06 2009-12-10 Bay Street Medical Prosthesis and delivery system
US8636760B2 (en) 2009-04-20 2014-01-28 Covidien Lp System and method for delivering and deploying an occluding device within a vessel
WO2010151480A3 (en) * 2009-06-26 2011-05-19 Biosensor International Group, Ltd. Implant delivery apparatus and methods with electrolytic release
US8657870B2 (en) 2009-06-26 2014-02-25 Biosensors International Group, Ltd. Implant delivery apparatus and methods with electrolytic release
US9023095B2 (en) 2010-05-27 2015-05-05 Idev Technologies, Inc. Stent delivery system with pusher assembly
US10729412B2 (en) 2012-02-16 2020-08-04 Biotronik Ag Release device for releasing a medical implant from a catheter and catheter having a release device and method for clamping an implant therein
US20130338754A1 (en) * 2012-06-18 2013-12-19 Biotronik Ag Release device for releasing a medical implant from a catheter and catheter having a release device and implant for connection thereto and method for retaining the implant therein
US9155647B2 (en) 2012-07-18 2015-10-13 Covidien Lp Methods and apparatus for luminal stenting
US9877856B2 (en) 2012-07-18 2018-01-30 Covidien Lp Methods and apparatus for luminal stenting
US9301831B2 (en) 2012-10-30 2016-04-05 Covidien Lp Methods for attaining a predetermined porosity of a vascular device
US9907643B2 (en) 2012-10-30 2018-03-06 Covidien Lp Systems for attaining a predetermined porosity of a vascular device
US9114001B2 (en) 2012-10-30 2015-08-25 Covidien Lp Systems for attaining a predetermined porosity of a vascular device
US10206798B2 (en) 2012-10-31 2019-02-19 Covidien Lp Methods and systems for increasing a density of a region of a vascular device
US10952878B2 (en) 2012-10-31 2021-03-23 Covidien Lp Methods and systems for increasing a density of a region of a vascular device
US9452070B2 (en) 2012-10-31 2016-09-27 Covidien Lp Methods and systems for increasing a density of a region of a vascular device
US9943427B2 (en) 2012-11-06 2018-04-17 Covidien Lp Shaped occluding devices and methods of using the same
US9295393B2 (en) 2012-11-09 2016-03-29 Elwha Llc Embolism deflector
US9414752B2 (en) 2012-11-09 2016-08-16 Elwha Llc Embolism deflector
US9561122B2 (en) 2013-02-05 2017-02-07 Covidien Lp Vascular device for aneurysm treatment and providing blood flow into a perforator vessel
US9157174B2 (en) 2013-02-05 2015-10-13 Covidien Lp Vascular device for aneurysm treatment and providing blood flow into a perforator vessel
US9895245B2 (en) * 2013-03-06 2018-02-20 Cook Medical Technologies Llc Introducer sheath having a non-uniform inner surface
US20140257455A1 (en) * 2013-03-06 2014-09-11 Cook Medical Technologies Llc Introducer sheath having a non-uniform inner surface
US10945869B2 (en) 2017-03-09 2021-03-16 Cook Medical Technologies, LLC Low profile stent delivery system and method

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