US20040193178A1 - Multiple joint implant delivery systems for sequentially-controlled implant deployment - Google Patents
Multiple joint implant delivery systems for sequentially-controlled implant deployment Download PDFInfo
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- US20040193178A1 US20040193178A1 US10/746,452 US74645203A US2004193178A1 US 20040193178 A1 US20040193178 A1 US 20040193178A1 US 74645203 A US74645203 A US 74645203A US 2004193178 A1 US2004193178 A1 US 2004193178A1
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- implant
- delivery
- delivery guide
- guide member
- release
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/12—Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
- A61B17/12022—Occluding by internal devices, e.g. balloons or releasable wires
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/12—Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
- A61B17/12022—Occluding by internal devices, e.g. balloons or releasable wires
- A61B17/12099—Occluding by internal devices, e.g. balloons or releasable wires characterised by the location of the occluder
- A61B17/12109—Occluding by internal devices, e.g. balloons or releasable wires characterised by the location of the occluder in a blood vessel
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/12—Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
- A61B17/12022—Occluding by internal devices, e.g. balloons or releasable wires
- A61B17/12131—Occluding by internal devices, e.g. balloons or releasable wires characterised by the type of occluding device
- A61B17/12136—Balloons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/12—Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
- A61B17/12022—Occluding by internal devices, e.g. balloons or releasable wires
- A61B17/12131—Occluding by internal devices, e.g. balloons or releasable wires characterised by the type of occluding device
- A61B17/1214—Coils or wires
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B2017/00831—Material properties
- A61B2017/00867—Material properties shape memory effect
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/12—Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
- A61B17/12022—Occluding by internal devices, e.g. balloons or releasable wires
- A61B2017/1205—Introduction devices
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/12—Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
- A61B17/12022—Occluding by internal devices, e.g. balloons or releasable wires
- A61B2017/1205—Introduction devices
- A61B2017/12054—Details concerning the detachment of the occluding device from the introduction device
- A61B2017/12063—Details concerning the detachment of the occluding device from the introduction device electrolytically detachable
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B90/00—Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges
- A61B90/39—Markers, e.g. radio-opaque or breast lesions markers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/95—Instruments specially adapted for placement or removal of stents or stent-grafts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/95—Instruments specially adapted for placement or removal of stents or stent-grafts
- A61F2002/9505—Instruments specially adapted for placement or removal of stents or stent-grafts having retaining means other than an outer sleeve, e.g. male-female connector between stent and instrument
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/95—Instruments specially adapted for placement or removal of stents or stent-grafts
- A61F2002/9505—Instruments specially adapted for placement or removal of stents or stent-grafts having retaining means other than an outer sleeve, e.g. male-female connector between stent and instrument
- A61F2002/9511—Instruments specially adapted for placement or removal of stents or stent-grafts having retaining means other than an outer sleeve, e.g. male-female connector between stent and instrument the retaining means being filaments or wires
Definitions
- This invention relates to devices and methods for placing one or more implants such as helical scaffolds or occlusive members into tubular organs or open regions of the body.
- the implants may be of types that maintain patency of an open anatomical structure, occlude a selected volume, isolate a region, or collect other occlusive members at a site. Included in the description are devices and methods for deploying the various implants, typically without a sheath, in a serial fashion, and with high adjustibility.
- Implants such as stents and occlusive coils have been used in patients for a wide variety of reasons. For instance, stents are often used to treat arterial stenosis secondary to atherosclerosis.
- stents are often used to treat arterial stenosis secondary to atherosclerosis.
- Various stent designs have been developed and used clinically, but self-expandable and balloon-expandable stent systems and their related deployment techniques are now predominant. Examples of self-expandable stents currently in use are WALLSTENT® stents (Schneider Peripheral Division, Minneapolis, Minn.) and Gianturco stents (Cook, Inc., Bloomington, Ind.).
- the most commonly used balloon-expandable stent is the PALMAZ® stent (Cordis Corporation, Warren, N.J.).
- a self-expandable or balloon-expandable stent is advanced over a guidewire and positioned at the target site.
- a protective sheath or membrane is then retracted proximally to allow expansion of a self-expanding stent.
- a delivery balloon may be inflated, thereby expanding the stent.
- balloon-expandable stents by virtue of a large diameter and relative inflexibility, are often unable to reach distal vasculature.
- repositioning or step-wise release of the stent are usually not available features.
- occlusive coil placement systems such as systems that deliver detachable platinum coils and GDC® coils also generally do not contain repositionable or step-wise release features.
- the present invention is a low profile implant delivery device that may be deployed without a sheath, and is designed to release portions of implants simultaneously or sequentially.
- the implant delivery device includes a noninflatable, elongate delivery guide member having a distal end and configuration that allows it to direct at least one implant having an exterior and interior surface to an anatomical treatment site by manipulation by a user.
- the at least one implant has a delivery diameter prior to its release, is located proximally of the distal end of the delivery guide member prior to release, and has at least one releasable joint configured to maintain at least a section of the at least one implant at the delivery diameter until release of the at least one releasable joint.
- the delivery guide member sections that are proximal and distal to the at least one implant also have delivery diameters. These guide member delivery diameters may be substantially equal to the at least one implant delivery diameter prior to implant release.
- the implant may be a helical scaffold, e.g., a stent, in particular, a self-expandable stent, or it may be an occlusive coil.
- the implant may be symmetric or asymmetric. In some instances, the implant delivers a therapeutic agent.
- the delivery guide member may include a wire and/or a tubular member having a lumen. If desired, a radioopaque marker may be included on the delivery guide to aid with its placement. When designed to include a tubular member, it co-axially surrounds at least a portion of the delivery guide, and works as a tubular actuator configured to release at least one releasable joint upon distal axial movement along the delivery guide member.
- the implant delivery device includes an actuator slidably located at least partially within the delivery guide member and is configured to mechanically release at least one releasable joint upon axial movement of the actuator within the delivery guide member.
- the actuator may also release at least one releasable joint upon rotational movement of the actuator, upon the application of fluid pressure in the delivery guide member lumen, or upon application of a suitable DC current to the at least one releasable joint. Release of the releasable joints using any one of the release mechanisms described above may be sequential, if precise positioning is required, or may be simultaneous. Each feature of each variation may be used on any of the other variations.
- the implant delivery device may be included in a system for implant delivery which further employs one or more embolic filters at either the proximal or distal section of the delivery guide, or at both the proximal and distal sections of the delivery guide.
- the system may be used for implant delivery into lumens of tubular organs including, but not limited to, blood vessels (including intracranial vessels, large vessels, peripheral vessels, adjacent aneurysms, arteriovenous malformations, arteriovenous fistulas), ureters, bile ducts, fallopian tubes, cardiac chambers, ducts such as bile ducts and mammary ducts, large and small airways, and hollow organs, e.g., stomach, intestines, and bladder.
- the implant may be of a design that is of a size that is smaller during delivery and larger after implantation.
- the design may be used to provide or to maintain patency in an open region of an anatomical structure, or to occlude a site, or to isolate a region (e.g., to close an aneurysm by blocking the aneurysm opening or neck by placement in an adjacent anatomical structure such as an artery or gastrointesinal tubular member), or to corral or collect a number of occlusive devices (e.g., coils or hydratable polymeric noodles) or compositions at a site to be occluded or supported.
- the implant is located in a gap between proximal and distal sections of the delivery guide member.
- the system may also be employed for implant delivery into solid organs or tissues including, but not limited to, skin, muscle, fat, brain, liver, kidneys, spleen, and benign and malignant tumors.
- the implant is delivered to a target site in a blood vessel lumen.
- the system is a guidewire-less implant delivery system that includes a noninflatable, elongate delivery guide member having a proximal end and a distal end.
- the guide member is configured to direct at least one implant having an exterior and interior surface to an anatomical treatment site by manipulation by a user.
- the at least one implant has a delivery diameter prior to release of the at least one implant and is located proximally of the distal end of the delivery guide member prior to release.
- the at least one releasable joint is configured to maintain at least a section of the at least one implant at the delivery diameter until release of the at least one releasable joint.
- the guidewire-less system also has a flexibility and remote directability such that a user may direct the distal end of the guide member into, and introduce, the at least one implant into a coronary artery solely by manipulation of the delivery guide member from its proximal end.
- FIG. 1A is a side view of an implant delivery device with a partial cross-section of the distal section of the delivery guide.
- FIG. 1B is a cross-sectional view of the delivery guide and implant taken at line 1 B- 1 B in FIG. 1A.
- FIG. 2 is a side view of an implant delivery device having a tubular member (actuator) attached to the proximal implant end with a partial cross-section of the distal section of the delivery guide.
- FIG. 3A is a side:view of the implant in FIG. 2 being expanded by distally moving the tubular member towards the distal section of the delivery guide.
- FIG. 3B is a longitudinal cross-sectional view of a distal implant release mechanism.
- FIGS. 3C 1 and 3 C 2 are longitudinal cross-sectional views of an implant delivery device having a mechanical release mechanism for deploying one end of an implant.
- FIGS. 3D 1 - 3 D 3 are longitudinal cross-sectional views of an implant delivery device having a mechanical release mechanism for independently releasing the implant ends.
- FIGS. 3E 1 - 3 E 4 are longitudinal cross-sectional views of an implant delivery device having a hydraulic release mechanism for independently releasing the implant ends.
- FIGS. 3F 1 - 3 F 2 are longitudinal cross-sectional views of a variation of the hydraulic release mechanism described in 3 E 1 - 3 E 4 .
- FIGS. 3G 1 - 3 G 3 are longitudinal cross-sectional views of an implant delivery device having a mechanical release mechanism according to another variation of the invention.
- FIG. 4 is a longitudinal cross-sectional view of an implant delivery device having a mechanical release mechanism according to yet another variation of the invention.
- FIGS. 5A-5C are longitudinal cross-sectional views of an implant delivery device having an electrolytic implant release mechanism.
- FIG. 5D shows a longitudinal cross-sectional view of an implant delivery device having an electrolytic release mechanism according to another variation of the invention.
- FIG. 5E shows a longitudinal cross-sectional view of an implant delivery device having a thermal release mechanism according to one variation of the invention.
- FIGS. 6A-6D show the general method for serially releasing an implant at a target site.
- region refers to luminal structures as well as solid organs and solid tissues of the body, whether in their diseased or nondiseased state.
- luminal structures include, but are not limited to, blood vessels, arteriovenous malformations, aneurysms, arteriovenous fistulas, cardiac chambers, ducts such as bile ducts and mammary ducts, fallopian tubes, ureters, large and small airways, and hollow organs, e.g., stomach, intestines, and bladder.
- Solid organs or tissues include, but are not limited to, skin, muscle, fat, brain, liver, kidneys, spleen, and benign and malignant tumors.
- the device assembly generally includes an elongate, perhaps solid delivery guide, an implant, and one or more implant release mechanisms.
- Guidewire-less systems are used to deliver the one or more implants.
- guidewire-less it is meant that the system does not require a guiding device of a diameter less than that of the guide member upon which the implant is delivered to reach a chosen implantation site.
- the guidewire-less system is flexible and remotely directable, the remote directability being such that a user may direct the distal end of the guide member into, and introduce, the at least one implant into a coronary artery solely by manipulation of the delivery guide member from its proximal end.
- the delivery guide is elongate and has a comparatively small effective diameter. It has the function of permitting delivery of the implant to a selected site and supporting the implant in a collapsed form during positioning and implantation.
- the delivery guide is usually noninflatable. It may also be solid, or may have a lumen extending therethrough, depending on such factors as the degree of flexibility required, type of associated release mechanism, the constitution material, and the like.
- the tip of the delivery guide may be tapered and/or straight, curved, or j-shaped, depending on factors such as physician preference, the anatomy of the tubular organ or region of interest, degree of stiffness required, and the like.
- the delivery guide may or may not include an outer spring coil, for, e.g., fluoroscopic visualization.
- the delivery guide member and the delivery system into which it is placed desirably serves the function as would a guidewire in, for instance, a cardiac or neurovascular catheterization procedure.
- the concept that the delivery guide member or system including that guide member and implant(s) is “remotely directable” is to say that the combination of physical parameters of the delivery guide member, implant, and joints are selected to allow advancement of the system much in the same way as would be a guidewire.
- Such physical parameters include, for instance, choice of materials, stiffness, size of materials, physical or chemical treatment, tapering (if desired), all in the same way that those physical parameters are selected in designing a cardiovascular or neurovascular guidewire.
- the delivery guide may be made from any biocompatible material including, but not limited to, stainless steel and any of its alloys; titanium alloys, e.g., nickel-titanium alloys; other shape memory alloys; tantalum; polymers, e.g., polyethylene and copolymers thereof, polyethylene terephthalate or copolymers thereof, nylon, silicone, polyurethanes, fluoropolymers, poly (vinylchloride), and combinations thereof.
- biocompatible material including, but not limited to, stainless steel and any of its alloys; titanium alloys, e.g., nickel-titanium alloys; other shape memory alloys; tantalum; polymers, e.g., polyethylene and copolymers thereof, polyethylene terephthalate or copolymers thereof, nylon, silicone, polyurethanes, fluoropolymers, poly (vinylchloride), and combinations thereof.
- the diameter of the delivery guide may usually be about 0.013 cm to about 0.130 cm (about 0.005 inches to about 0.05 inches), more usually about 0.013 cm to about 0.076 cm (about 0.005 inches to about 0.03 inches), and more usually still about 0.015 cm to about 0.030 cm (about 0.006 inches to about 0.012 inches). In a preferred variation, the diameter of the delivery guide is approximately about 0.020 cm (about 0.008 inches).
- a lubricious coating may be placed on the delivery guide if desired to facilitate advancement of the delivery guide.
- the lubricious coating typically will include hydrophilic polymers such as polyvinylpyrrolidone-based compositions, fluoropolymers such as tetrafluoroethylene, or silicones.
- the lubricious coating may constitute a hydrophilic gel.
- the delivery guide may include one or more radioopaque markers that indicates the location of the distal section of the delivery guide upon radiographic imaging. Usually, the marker will be detected by fluoroscopy.
- the implant itself may be of a shape tailored to achieve a specific purpose. As noted elsewhere, if the purpose of the implant is to provide or to maintain patency of an anatomical structure such as an artery or duct, the implant shape after implantation is itself tubular. The shape may be symmetric or asymmetric, as the purpose dictates.
- Other shapes including cage structures, may be used to provide patency to vessels or to act as collecting or coralling structures for occlusive members or materials.
- the implant may have the form of an occlusive coil that remains helical after deployment or assumes a random orientation.
- the implant for placement into a luminal structure is a helical scaffold, e.g., a stent, but any scaffold shape that maintains patency of a lumen may be used.
- the stents are typically self-expanding stents, such as described in U.S. Pat. No. 4,768,507 to Fishell et al., U.S. Pat. No. 4,990,155 to Wilkoffet al., and U.S. Pat. No. 4,553,545 to Maass et al.
- the implant is an occlusive member, e.g., an occlusive coil, such as described in U.S. Pat. No. 5,334,210 to Gianturco and U.S. Pat. No. 5,382,259 to Phelps et al.
- the interior and exterior surfaces of the implant may be designed to prevent the activation of pathological processes during or after implant deployment.
- the exterior stent surface may be formed to be smooth to decrease the likelihood of intimal damage upon stent release (which would trigger the inflammatory process and attract atheromatous plaque-forming cells).
- the interior stent surface may also be smooth to minimize turbulent flow through the stent and decrease the risk of stent thrombosis.
- Important physical properties of the implant to consider include, but are not limited to: length, (stent) diameter in the expanded state, degree of flexibility and lateral stiffness, and the like. These physical properties will be modified to account for such factors as lumen diameter, length of any stenosis, type of luminal structure, or solid organ or tissue involved.
- Metals such as stainless steel and tantalum, or metal alloys such as alloys of nickel and titanium, specifically including superelastic alloys such as NITINOL or Elgiloy which are commonly used by those of skill in the art, may be used to form the implants.
- the implants may also be made from biodegradable polymers, e.g., copolymers of lactic and glycolic acid, or nonbiodegradable polymers, e.g., copolymers of ethylene and vinyl acetate.
- the implants may also include a therapeutic agent.
- therapeutic agents that may be used in the implants include, but are not limited to, antibiotics, anticoagulants, antifungal agents, anti-inflammatory agents, antineoplastic agents, antithrombotic agents, endothelialization promoting agents, free radical scavengers, immunosuppressive agents, thrombolytic agents, and any combination thereof. If the implant is a stent, an antithrombotic agent is preferably included.
- Examples of selective antithrombotic agents include acetylsalicylic acid, argatroban, cilostazol, copidogrel, cloricromen, dalteparin, daltroban, defibrotide, dipyridamole, enoxaparin, epoprostenol, indobufen, iloprost, integrelin, isbogrel, lamifiban, lamoparan, nadroparin, ozagrel, picotamide, plafibride, reviparin sodium, ridogrel, sulfinpyrazone, taprostene, ticlopidine, tinzaparin, tirofiban, triflusal, and any of their derivatives.
- the therapeutic agent may be coated onto the implant, mixed with a biodegradable polymer or other suitable temporary carrier and then coated onto the implant, or, when the implant is made from a polymeric material, dispersed throughout the polymer.
- the implant may include a radioactive material.
- the radioactive material may be selected on the basis of its use. For instance, the material may be included in an implant where the implant is in the form of a stent that is to be situated over a vascular stenosis. The radioactivity lowers the incidence of re-stenosis. Additionally, the radioactivity may serve the function of a tracer, to allow detection of the location of the implant during the procedure or anytime thereafter. Suitable radioactive tracers include isotopes of gallium, iodine, technetium, and thallium.
- the implant delivery system includes a delivery guide 100 .
- Delivery guide 100 has a proximal section 102 and a distal section 104 .
- An implant in this case depicted as a stent 106 , surrounds a portion of the distal section 104 of the delivery guide, and is releasably attached to the distal section 104 of the delivery guide.
- the implant 106 as shown in FIG. 11B, is concentrically adjacent to the delivery guide 100 .
- Implant 106 is shown to be directly attached to, is contiguous to, the delivery guide 100 at the proximal end 108 of the implant and distal end 110 of the implant.
- implant 106 may be secured to the delivery guide 100 by such generic controllably releasable mechanisms as mechanical, thermal, hydraulic, and electrolytic mechanisms, or a combination thereof. Examples of these release mechanisms will be discussed below.
- release of the implant 106 from the delivery guide 100 may be achieved through a mechanical detachment process involving, e.g., twisting of the delivery guide, such as described by Amplatz in U.S. Pat. No. 6,468,301, or translational movement of the delivery guide in relation to the implant.
- Implant release may also be achieved using a thermally detachable joint, such as described in U.S. Pat. No. 5,108,407 to Geremia et al., an electrolytic detachable joint, such as described in U.S. Pat. Nos. 5,122,136 and 5,354,295, both to Gulglielmi et al., or a combination thereof.
- the system includes a tubular member 200 co-axially mounted on a delivery guide 202 .
- Tubular member 200 may form a component of the delivery guide 202 that cooperates with one or more of the releasable mentioned joints on the implant ( 209 , 211 ) to release those joints (and therefore, release the implant 204 ) upon application of a releasing movement, axial or twisting.
- An implant e.g., a stent 204
- the distal end 208 of the tubular member is attached to the proximal end 210 of the stent.
- the distal end 212 of the stent is attached using a releasable joint 211 to the distal section 206 of the delivery guide 202 .
- FIG. 3A shows a stent 300 expanding as tubular member 302 is moved distally on the delivery guide 304 , in the direction of the arrow. The stent is then released from the delivery guide.
- the distal end 306 of the stent is released from a distal section 308 of the delivery guide, followed by release of the proximal end 310 of the stent from the distal end 312 of the tubular member.
- the stent 300 may be secured to a distal section 308 of the delivery guide by such mechanisms as lock and key arrangements, biocompatible adhesives, soldering, or a combination thereof. Consequently, stent release may be achieved through a mechanical detachment process, a thermal detachment process (e.g., by heat produced from an exothermic reaction), an electrolytic detachment process, or a combination thereof.
- FIGS. 3B and 3C show yet another variation of a stent release mechanism.
- brackets 314 may be used to couple the stent 300 to the distal section 308 of the delivery guide. Separation of the stent 306 from the brackets 314 , e.g., by one of the detachment processes mentioned above, releases the distal end 306 of the stent from a distal section 308 of the delivery guide, allowing the stent distal end 306 to expand in the tubular organ.
- Brackets 314 couple the stent proximal end 310 to the distal region 312 of the tubular member 313 that forms a portion of the delivery guide.
- the brackets 314 have a ramped region 316 which are proximally adjacent to an enlarged (and perhaps ball- or barrel-shaped) portion 318 of the delivery guide and bracket arms 320 .
- the delivery guide and stent each have a delivery diameter, and these delivery diameters may be substantially equal prior to release of the stent.
- the ball-shaped portion 318 forces the ramped regions 316 of the brackets outward from the delivery guide axis, in a radial fashion, causing the bracket arms 320 to be displaced radially outwardly from the proximal end 310 of the stent, thereby releasing the stent proximal end 310 .
- FIG. 3C 2 shows the results of moving the actuator 305 proximally.
- the clips ( 316 ) have rotated as shown due to the force exerted upon the ramps ( 317 ) by the ball ( 318 ).
- the implant ( 320 ) has expanded in diameter from that found in its undelivered form.
- the actuator may be attached, perhaps with a distal radioopaque coil or directly, to a distal section (not shown) of the guide member.
- FIG. 3D 1 shows a delivery system 319 in which the two ends of the implant 321 may be independently deployed by using an actuator 304 having a proximal releasing ball 322 and a distal releasing ball 327 .
- the implant 321 is located in a gap between sections of the delivery guide and are releasably attached to the delivery guide by brackets or clips.
- the two balls are spaced in such a way that, in the variation shown in FIG. 3D 1 , the distal ball 327 releases the distal end 331 of implant 321 and the proximal ball 322 then releases the proximal end 329 of implant 321 upon additional proximal movement of actuator 304 .
- This sequence of events is shown in FIGS.
- the implant 321 is shown to be completely released in FIG. 3D 3 .
- the implant 321 may be self-expanding, e.g., constructed of a superelastic alloy such as nitinol or another alloy having high elasticity, e.g., an appropriate stainless steel.
- a structure similar to that shown in FIGS. 3D 1 , 3 D 2 , and 3 D 3 may also be used to deploy an implant using fluid pressure as the releasing impetus.
- FIGS. 3E 1 , 3 E 2 , 3 E 3 and 3 E 4 show a hydraulic variation. Shown are the delivery guide 350 , having a hollow lumen 352 , a self-expanding implant 354 (shown variously as non-expanded (e.g., in a “first form”) in FIG. 3E 1 , partially expanded in FIG. 3E 2 , and fully expanded in FIGS. 3E 3 and 3 E 4 (e.g., in a “second form”)), and an actuator 356 with a sealing member 358 and a radio-opaque member 360 .
- a self-expanding implant 354 shown variously as non-expanded (e.g., in a “first form”) in FIG. 3E 1 , partially expanded in FIG. 3E 2 , and fully expanded in FIGS. 3E 3 and 3 E 4 (e.g., in a “second form”)
- an actuator 356 with a sealing member 358 and a radio-opa
- the implant 354 (here shown to be a stent or the like) is held to the delivery guide 350 during delivery to the selected treatment site using distal brackets 364 and proximal brackets 362 or clips or the like.
- the proximal and distal brackets ( 364 , 362 ) either include regions that cooperate with the fluid in lumen 352 to move upon application of increased pressure in that lumen 352 and release the implant 350 or move in concert with a separate pressure sensitive motion component.
- FIG. 3E 1 shows the actuator 356 as the sealing member 358 approaches the various orifices or openings (proximal orifices 366 and distal orifices 368 ) communicating from the lumen 356 to the hydraulically or fluidly actuatable clips or retaining brackets (proximal brackets 362 and distal brackets 364 ).
- a radio-opaque marker 360 on the actuator shaft 356 that allows the user to simply line up that actuator marker 360 with a corresponding radio-opaque marker 370 or the delivery guide 350 , increase the pressure in lumen 352 (via syringe, pump, etc.) and deploy the proximal end 371 of implant 354 .
- the interior pressure raises or rotates the proximal clips or brackets 362 and moves them out of contact with the implant 354 .
- FIG. 3E 2 shows the movement of the proximal end of implant 354 away from the delivery guide 350 .
- FIG. 3E 3 shows the axial movement of actuator 356 distally to a position where the sealing member 358 is positioned to actuate distal clips or brackets 364 and release the distal end of implant.
- a radio-opaque marker 374 (perhaps with an additional identification band 376 ) has been depicted to show alignment of the radio-opaque marker or band 360 on the actuator shaft 356 prior to the increase in pressure for deployment.
- FIG. 3E 4 shows final deployment at the implant 354 and proximal movement at the actuator 356 , just prior to withdrawal of the delivery guide 350 .
- the distal and proximal clips or brackets ( 362 , 364 ) have relaxed to the surface of the delivery guide 350 .
- FIGS. 3F 1 and 3 F 2 Alternatives to certain of the elements shown in the variation found in FIGS. 3E 1 to 3 E 4 is seen in FIGS. 3F 1 and 3 F 2 and includes, e.g., a cover element 380 to block or cover proximal orifices 366 during the pressurization of the distal orifices 368 .
- the cover element 380 includes holes 382 to allow fluid flow past the cover element 380 .
- FIG. 3G shows a variation of the described system in which an implant or stent 371 is maintained in position on a hollow delivery guide 373 using spring clips 375 proximally and 377 distally.
- the spring clips hold the implant 371 in place during delivery and against guide member 373 .
- An actuator 379 is used to remove the clips 375 , 377 sequentially and to release each end of implant 371 in an independent fashion. Clips 375 and 377 , after actuation or release, remain interior to the guide member 373 for later removal with that guide member.
- the system shown in FIGS. 3G 1 , 3 G 2 and 3 G 3 may be used to deliver a number of implants in a sequential fashion.
- the actuator 379 is able to slide past the site on guide member 373 where the clips 375 , 377 resided prior to implant 371 deployment, down to and distally to a site on the guide member having another implant for subsequent delivery. Consequently, an arrangement such as this may be used to deploy, in a sequential fashion, a number of stents or the like without withdrawal of the guide member.
- the clips 375 and 377 are spring-biased to collapse within the lumen 381 of the guide member 373 once they are pushed into the respective slots 383 provided for such retraction.
- Such spring loaded clips retain the self expanding stent or implant 371 onto the face of guide member 373 .
- Each of clips 375 , 377 are shown in this variation to have hook members 387 , 389 that engage the implant 371 , often axially stretching the implant 371 and maintaining the delivery radius of the implant 371 as shown.
- actuator 379 is pushed distally along the outer surface of guide member 373 until it contacts the proximal end of clip 375 . Further distal movement of actuator 379 urges clip 375 into lumen 381 thereby rotating horn 387 out of cooperating receptacle area in implant 371 .
- FIG. 3G 2 shows the results of such movement after clip 375 has completed its springed closure within lumen 381 .
- the proximal end of implant 371 has expanded and yet the distal end of implant 371 remains closed and hooked to distal clip 377 .
- This semi-open condition allows for some adjustment of the implant if needed.
- FIG. 3G 3 shows the results of additional distal movement of actuator 379 until it contacts distal clip 377 (shown in FIG. 3G 3 in its collapsed form ) and thereby allowing the distal end of implant 371 to self-expand into the chosen treatment site.
- FIG. 3G 3 shows that guide member 379 is free.
- Implant 371 is shown in its self expanded form no longer adjacent the central guide member 379 .
- Actuator 379 is situated within implant 371 and is no longer in contact with proximal clip 375 nor distal clip 377 . Actuator 379 is thus able to continue distally to another implant containing site positioned in a more distal site on the guide member 373 .
- FIGS. 3G 1 , 3 G 2 , 3 G 3 may be modified in such a way that the actuator is interior to the lumen of the guide member and deploys the implant upon distal movement of the actuator by providing an actuator with a slot or other “room-making” provisions in the actuator. The actuator and any retained clips would then be used to actuate the clips in the next more distal implant if so desired.
- the system releases an implant (shown as a stent 404 in FIG. 4) attached to a delivery guide 400 by one or more attachment arms 402 positioned, e.g., at the implant proximal and distal ends, by sliding a tubular member 406 , mounted co-axially on the delivery guide 400 , distally over the delivery guide 400 .
- the stent 404 is secured to the delivery guide 400 when the attachment arms 402 are in a radially expanded configuration (as illustrated in FIG. 4).
- the tubular member 406 urges the attachment arms 402 into a compressed configuration as it slides distally over the delivery guide 400 , in the direction of the arrow.
- the attachment arms 402 When the attachment arms 402 are compressed by the tubular member 406 , they are moved inward from the stent 404 , toward the central axis of the delivery guide 400 , thereby releasing the stent 404 from the delivery guide 400 .
- Stent detachment occurs in a serial fashion as the tubular member 406 is moved distally, with detachment of the stent proximal end 408 occurring before detachment at the stent distal end 410 . Consequently, if the stent position requires readjustment after detachment of the stent proximal end, the stent may be repositioned prior to detaching the stent distal end.
- the tubular member is a balloon catheter.
- the attachment arms 402 are generally made from the same materials as the delivery guide 400 , e.g., stainless steel or nickel-titanium alloy, and will typically have a length, thickness, shape, and flexibility appropriate for its intended mechanism of release.
- the distal ends 412 of the attachment arms may be of any design, so long as one or more of them, when in a radially expanded configuration, secures a portion of a stent to a delivery guide, and when in a compressed configuration, releases that same stent portion from the delivery guide.
- the tubular member may be a thin-walled tube (e.g., approximately 0.005 cm (0.002 inches) in thickness) with an outside diameter ranging from about 0.025 cm to about 0.139 cm (0.010 inches to about 0.055 inches), more usually from about 0.025 cm to about 0.05 cm (0.010 inches to about 0.020 inches), and more usually still from about 0.025 cm to about 0.035 cm (0.010 inches to about 0.014 inches).
- they may be made from various metals or metal alloys, including, but not limited to, stainless steel and nickel-titanium alloy, or from various polymers, such as polyvinyl chloride, polyethylene, polyethylene terephthalate, and polyurethane.
- FIGS. 5A, 5B, and 5 C show a variation of the described delivery system 500 in which a member of electrolytic delivery joints are used to deploy an implant 502 , such as a stent.
- the electrolytic delivery joints shown here are well known as controllable delivery joints for placement of vaso-occlusive coils.
- One such commercially available device using an electrolytically detachable joint is sold by Target Therapeutics, a subsidiary of Boston Scientific Corp., as the Guglielmi Detachable Coil (or “GDC”). Numerous patents to Dr. Guglielmi describe the theory of its use.
- the electrolytically erodible joint is a section of an electrical circuit that is not insulated and is of a metallic material that does not form insulating oxides when exposed to an aqueous environment (e.g., aluminum and tantalum) and is sufficiently “non-noble” that is will either electrolytically erode by ionic dissolution into an anatomical fluid or, perhaps, electrochemically erode by forming readily soluble oxides or salts.
- an aqueous environment e.g., aluminum and tantalum
- the erodible joint 504 shown in FIG. 5C is a bare metal of a size, diameter, etc. that erodes away when a current is applied to insulated wire 506 .
- the current flow is from a power supply through insulated wire 506 , bare joint 504 , into the ionic anatomical fluid surrounding the site to be treated, and back to a return electrode situated perhaps on the patient's skin and then back to the power supply.
- the current flows through the circuit so long as the joint 504 exists.
- FIG. 5A shows a device having several joints ( 504 , 508 , 510 , 512 ) that each may be independently severed to controllably deploy the implant 502 .
- Implant 502 is shown having coils ( 514 , 516 ) that are terminated at each end by an erodible joint and that, prior to the severing of a joint, hold this implant 502 to the surface of the delivery member 520 .
- the implant 500 is self-expanding, once released.
- the wires forming the two coils in this variation slide within the implant or “uncoil” and thereby allow the implant body itself to expand.
- the coils may comprise (if electrically connected to the erodible joint) a metal that is higher in the Mendelev Electromotive Series than is the composition at the electrolytic joint or the coils may comprise a polymer that may be bio-erodible or not.
- a suitable way to assure that the coils ( 514 , 516 ) maintain the low profile of the implant 502 during delivery is via the placement of the various conductive wires ( 506 , 516 , 518 , 520 ) through the adjacent holes ( 524 , 526 , 528 ) and fill the holes with e.g., an epoxy to hold all in place. Independently causing current to flow through each of the joints will release the implant in the region of the released joint Once all joints are eroded, the implant is released.
- detachment from a delivery guide is not so limited.
- the stent is attached to the delivery guide at one or more positions along the length of the stent, in addition to attachment at the proximal and distal implant ends. Once the distal stent end is released, the additional attachments may be independently released until detachment at the proximal implant end releases the implant entirely from the delivery guide. Serial release may provide better control of positioning in tubular organs.
- FIGS. 5D and 5E show in more detail, the components of an electrolytic joint (as may be found in FIGS. 5A, 5B and 5 C) and another electrically actuated joint using a meltable or softenable or polymerically sizable joint
- FIG. 5D shows the insulated wire 524 with insulation 523 and conductor 525 .
- the electrolytic joint 504 is also shown.
- the wire 524 is shown to be secured into the delivery guide wall 520 by, e.g., an epoxy 527 , an alternative or cooperative band or component 529 holding the wire 524 to the surface of guide member 520 is also shown.
- the implant of 502 expands and leaves the securement band 529 on the delivery guide 520 .
- FIG. 5E shows a similar variation but the joint comprises a thermoplastic adhesive or shape changing polymer 531 situated on the end of wire 525 and within a cup or other receptacle 533 .
- the adhesive is of the type that changes form or viscosity upon application of current to the joint.
- the thermoplastic is rendered conductive, but resistive, by introduction of material such as carbon black into the polymeric adhesive. As soon as the polymer changes its shape, form, or phase, the implant expands to the desired form about the central guide member 520 again, the wire may be held in place with an adhesive 527 if so desired.
- the implant delivery devices described herewith may include multiple implants on a single delivery guide or may be used in conjunction with other instruments, as seen appropriate, to treat the target site.
- the tubular organ of interest is percutaneously accessed, but the method of accessing will usually be dependent on the anatomy of the organ, medical condition being treated, health status of the subject, and the like. Consequently, access by a laparoscopic or open procedure may also be obtained.
- FIGS. 6A-6D show the general method of deploying a stent using my described system.
- a delivery guide 602 is placed through the selected area of stenosis 604 at the target site.
- a balloon catheter 606 is then advanced over the delivery guide 602 , and balloon angioplasty performed to dilate the area of stenosis 604 (FIG. 6B).
- the balloon catheter 606 is then retracted proximally and the delivery guide 602 exchanged for a stent delivery device 608 (FIG. 6C). Appropriate placement of the stent is guided by radioopaque markers 616 on the delivery guide 612 .
- the distal end 610 of the stent is then released from the delivery guide 612 .
- stent position may again be checked by verifying the location of the radioopaque markers.
- the proximal stent end 614 is then released from the delivery guide 612 .
- an embolic filter may be used during stent deployment to filter any debris generated during the procedure.
- the filter will usually be attached to the delivery guide such that it filters debris distal to the stent, but may also be attached to the delivery guide proximal to the stent, or both distal and proximal to the stent.
- the filter may be of any design, as long as it does not affect the substantially atraumatic, low profile, and controlled release characteristics of the stent delivery device.
- the filter is basket-shaped, and made from a shape-memory material, e.g., an alloy of titanium and nickel.
- the filter will usually be contained within the balloon catheter lumen, and deployed to its pre-designed shape once the balloon catheter is removed. Following placement of the stent, the balloon catheter may be advanced over the delivery guide to enclose the filter with any accumulated debris. The balloon catheter, filter, and delivery guide may then be removed from the body.
- the implant delivery system may be used in mammalian subjects, preferably humans. Mammals include, but are not limited to, primates, farm animals, sport animals, cats, dogs, rabbits, mice, and rats.
- the system may be employed for implant delivery into lumens of tubular organs including, but not limited to, blood vessels (including intracranial vessels, large vessels, peripheral vessels, aneurysms, arteriovenous malformations, arteriovenous fistulas), ureters, bile ducts, fallopian tubes, cardiac chambers, ducts such as bile ducts and mammary ducts, large and small airways, and hollow organs, e.g., stomach, intestines, and bladder.
- the system may also be employed for implant delivery into solid organs or tissues including, but not limited to, skin, muscle, fat, brain, liver, kidneys, spleen, and benign and malignant tumors.
- the implant is delivered to a target site in a blood vessel lumen.
- the system may generally be used to treat stenosis of various tubular organs, arising from such etiologies as atherosclerosis, autoimmune conditions, scarring, or exterior compression, e.g., as may be seen with a neoplastic process.
- the system may also be used to treat medical conditions in which luminal occlusion is desired, e.g., to treat aneurysms, arteriovenous fistulas, and arteriovenous malformations.
- the system may be employed to deliver implants into such areas as joint spaces, spinal discs, and the intraperitoneal or extraperitoneal spaces.
Abstract
The invention provides an atraumatic, low profile device for the delivery of one or more implants into tubular organs or open regions of the body. The implant delivery device may simultaneously or independently release portions of the implant, e.g., the proximal and distal ends of the implant. This independent release feature allows better implant positioning at the target site. Upon deployment, the implants may be placed at the target site without a sheath.
Description
- This invention relates to devices and methods for placing one or more implants such as helical scaffolds or occlusive members into tubular organs or open regions of the body. The implants may be of types that maintain patency of an open anatomical structure, occlude a selected volume, isolate a region, or collect other occlusive members at a site. Included in the description are devices and methods for deploying the various implants, typically without a sheath, in a serial fashion, and with high adjustibility.
- Implants such as stents and occlusive coils have been used in patients for a wide variety of reasons. For instance, stents are often used to treat arterial stenosis secondary to atherosclerosis. Various stent designs have been developed and used clinically, but self-expandable and balloon-expandable stent systems and their related deployment techniques are now predominant. Examples of self-expandable stents currently in use are WALLSTENT® stents (Schneider Peripheral Division, Minneapolis, Minn.) and Gianturco stents (Cook, Inc., Bloomington, Ind.). The most commonly used balloon-expandable stent is the PALMAZ® stent (Cordis Corporation, Warren, N.J.).
- Typically, after balloon angioplasty has been performed, either a self-expandable or balloon-expandable stent is advanced over a guidewire and positioned at the target site. A protective sheath or membrane is then retracted proximally to allow expansion of a self-expanding stent. Alternatively, a delivery balloon may be inflated, thereby expanding the stent.
- Despite improvements in delivery systems, balloon design, and stent design, these over-the-guidewire and/or sheathed self-expanding stent deployment systems still have their limitations. For instance, sheathed stents tend to move forward when the sheath is pulled back, deploying them imprecisely. The sheathed design also requires that the stent delivery system be larger in diameter and less flexible. Furthermore, for sheathed systems, the interventional procedure may only proceed if the vessel of interest is of sufficiently large diameter to allow sheath placement to avoid significant damage to the luminal surface of the vessel. Moreover, balloon-expandable stents, by virtue of a large diameter and relative inflexibility, are often unable to reach distal vasculature. For both self-expandable and balloon-expandable stent deployment systems, repositioning or step-wise release of the stent are usually not available features. Similarly, occlusive coil placement systems such as systems that deliver detachable platinum coils and GDC® coils also generally do not contain repositionable or step-wise release features.
- Consequently, a smaller diameter (lower profile), repositionable implant deployment device that releases an implant into, or upon, a body region in a more precise, continuous or step-wise fashion, without the use of a sheath or balloon would provide significant benefit to patients with various medical conditions.
- The present invention is a low profile implant delivery device that may be deployed without a sheath, and is designed to release portions of implants simultaneously or sequentially.
- In one variation, the implant delivery device includes a noninflatable, elongate delivery guide member having a distal end and configuration that allows it to direct at least one implant having an exterior and interior surface to an anatomical treatment site by manipulation by a user. The at least one implant has a delivery diameter prior to its release, is located proximally of the distal end of the delivery guide member prior to release, and has at least one releasable joint configured to maintain at least a section of the at least one implant at the delivery diameter until release of the at least one releasable joint. The delivery guide member sections that are proximal and distal to the at least one implant also have delivery diameters. These guide member delivery diameters may be substantially equal to the at least one implant delivery diameter prior to implant release.
- The implant may be a helical scaffold, e.g., a stent, in particular, a self-expandable stent, or it may be an occlusive coil. The implant may be symmetric or asymmetric. In some instances, the implant delivers a therapeutic agent.
- The delivery guide member may include a wire and/or a tubular member having a lumen. If desired, a radioopaque marker may be included on the delivery guide to aid with its placement. When designed to include a tubular member, it co-axially surrounds at least a portion of the delivery guide, and works as a tubular actuator configured to release at least one releasable joint upon distal axial movement along the delivery guide member.
- In another variation, the implant delivery device includes an actuator slidably located at least partially within the delivery guide member and is configured to mechanically release at least one releasable joint upon axial movement of the actuator within the delivery guide member. In other variations, the actuator may also release at least one releasable joint upon rotational movement of the actuator, upon the application of fluid pressure in the delivery guide member lumen, or upon application of a suitable DC current to the at least one releasable joint. Release of the releasable joints using any one of the release mechanisms described above may be sequential, if precise positioning is required, or may be simultaneous. Each feature of each variation may be used on any of the other variations.
- The implant delivery device may be included in a system for implant delivery which further employs one or more embolic filters at either the proximal or distal section of the delivery guide, or at both the proximal and distal sections of the delivery guide.
- The system may be used for implant delivery into lumens of tubular organs including, but not limited to, blood vessels (including intracranial vessels, large vessels, peripheral vessels, adjacent aneurysms, arteriovenous malformations, arteriovenous fistulas), ureters, bile ducts, fallopian tubes, cardiac chambers, ducts such as bile ducts and mammary ducts, large and small airways, and hollow organs, e.g., stomach, intestines, and bladder. The implant may be of a design that is of a size that is smaller during delivery and larger after implantation. The design may be used to provide or to maintain patency in an open region of an anatomical structure, or to occlude a site, or to isolate a region (e.g., to close an aneurysm by blocking the aneurysm opening or neck by placement in an adjacent anatomical structure such as an artery or gastrointesinal tubular member), or to corral or collect a number of occlusive devices (e.g., coils or hydratable polymeric noodles) or compositions at a site to be occluded or supported. In another variation, the implant is located in a gap between proximal and distal sections of the delivery guide member. The system may also be employed for implant delivery into solid organs or tissues including, but not limited to, skin, muscle, fat, brain, liver, kidneys, spleen, and benign and malignant tumors. Preferably, the implant is delivered to a target site in a blood vessel lumen.
- In a general aspect, the system is a guidewire-less implant delivery system that includes a noninflatable, elongate delivery guide member having a proximal end and a distal end. The guide member is configured to direct at least one implant having an exterior and interior surface to an anatomical treatment site by manipulation by a user. The at least one implant has a delivery diameter prior to release of the at least one implant and is located proximally of the distal end of the delivery guide member prior to release. The at least one releasable joint is configured to maintain at least a section of the at least one implant at the delivery diameter until release of the at least one releasable joint. The guidewire-less system also has a flexibility and remote directability such that a user may direct the distal end of the guide member into, and introduce, the at least one implant into a coronary artery solely by manipulation of the delivery guide member from its proximal end.
- FIG. 1A is a side view of an implant delivery device with a partial cross-section of the distal section of the delivery guide.
- FIG. 1B is a cross-sectional view of the delivery guide and implant taken at line1B-1B in FIG. 1A.
- FIG. 2 is a side view of an implant delivery device having a tubular member (actuator) attached to the proximal implant end with a partial cross-section of the distal section of the delivery guide.
- FIG. 3A is a side:view of the implant in FIG. 2 being expanded by distally moving the tubular member towards the distal section of the delivery guide.
- FIG. 3B is a longitudinal cross-sectional view of a distal implant release mechanism.
- FIGS. 3C1 and 3C2 are longitudinal cross-sectional views of an implant delivery device having a mechanical release mechanism for deploying one end of an implant.
- FIGS. 3D1-3D3 are longitudinal cross-sectional views of an implant delivery device having a mechanical release mechanism for independently releasing the implant ends.
- FIGS. 3E1-3E4 are longitudinal cross-sectional views of an implant delivery device having a hydraulic release mechanism for independently releasing the implant ends.
- FIGS. 3F1-3F2 are longitudinal cross-sectional views of a variation of the hydraulic release mechanism described in 3E1-3E4.
- FIGS. 3G1-3G3 are longitudinal cross-sectional views of an implant delivery device having a mechanical release mechanism according to another variation of the invention.
- FIG. 4 is a longitudinal cross-sectional view of an implant delivery device having a mechanical release mechanism according to yet another variation of the invention.
- FIGS. 5A-5C are longitudinal cross-sectional views of an implant delivery device having an electrolytic implant release mechanism.
- FIG. 5D shows a longitudinal cross-sectional view of an implant delivery device having an electrolytic release mechanism according to another variation of the invention.
- FIG. 5E shows a longitudinal cross-sectional view of an implant delivery device having a thermal release mechanism according to one variation of the invention.
- FIGS. 6A-6D show the general method for serially releasing an implant at a target site.
- Described here are devices, systems, and methods for delivering implants into both open and solid regions of the body. The term “region” as used herein refers to luminal structures as well as solid organs and solid tissues of the body, whether in their diseased or nondiseased state. Examples of luminal structures include, but are not limited to, blood vessels, arteriovenous malformations, aneurysms, arteriovenous fistulas, cardiac chambers, ducts such as bile ducts and mammary ducts, fallopian tubes, ureters, large and small airways, and hollow organs, e.g., stomach, intestines, and bladder. Solid organs or tissues include, but are not limited to, skin, muscle, fat, brain, liver, kidneys, spleen, and benign and malignant tumors.
- The device assembly generally includes an elongate, perhaps solid delivery guide, an implant, and one or more implant release mechanisms. Guidewire-less systems are used to deliver the one or more implants. By “guidewire-less” it is meant that the system does not require a guiding device of a diameter less than that of the guide member upon which the implant is delivered to reach a chosen implantation site. Instead, the guidewire-less system is flexible and remotely directable, the remote directability being such that a user may direct the distal end of the guide member into, and introduce, the at least one implant into a coronary artery solely by manipulation of the delivery guide member from its proximal end.
- The delivery guide is elongate and has a comparatively small effective diameter. It has the function of permitting delivery of the implant to a selected site and supporting the implant in a collapsed form during positioning and implantation. The delivery guide is usually noninflatable. It may also be solid, or may have a lumen extending therethrough, depending on such factors as the degree of flexibility required, type of associated release mechanism, the constitution material, and the like. The tip of the delivery guide may be tapered and/or straight, curved, or j-shaped, depending on factors such as physician preference, the anatomy of the tubular organ or region of interest, degree of stiffness required, and the like. The delivery guide may or may not include an outer spring coil, for, e.g., fluoroscopic visualization.
- The delivery guide member and the delivery system into which it is placed desirably serves the function as would a guidewire in, for instance, a cardiac or neurovascular catheterization procedure. The concept that the delivery guide member or system including that guide member and implant(s) is “remotely directable” is to say that the combination of physical parameters of the delivery guide member, implant, and joints are selected to allow advancement of the system much in the same way as would be a guidewire. Such physical parameters include, for instance, choice of materials, stiffness, size of materials, physical or chemical treatment, tapering (if desired), all in the same way that those physical parameters are selected in designing a cardiovascular or neurovascular guidewire.
- The delivery guide may be made from any biocompatible material including, but not limited to, stainless steel and any of its alloys; titanium alloys, e.g., nickel-titanium alloys; other shape memory alloys; tantalum; polymers, e.g., polyethylene and copolymers thereof, polyethylene terephthalate or copolymers thereof, nylon, silicone, polyurethanes, fluoropolymers, poly (vinylchloride), and combinations thereof. The diameter of the delivery guide may usually be about 0.013 cm to about 0.130 cm (about 0.005 inches to about 0.05 inches), more usually about 0.013 cm to about 0.076 cm (about 0.005 inches to about 0.03 inches), and more usually still about 0.015 cm to about 0.030 cm (about 0.006 inches to about 0.012 inches). In a preferred variation, the diameter of the delivery guide is approximately about 0.020 cm (about 0.008 inches).
- A lubricious coating may be placed on the delivery guide if desired to facilitate advancement of the delivery guide. The lubricious coating typically will include hydrophilic polymers such as polyvinylpyrrolidone-based compositions, fluoropolymers such as tetrafluoroethylene, or silicones. In one variation, the lubricious coating may constitute a hydrophilic gel. Furthermore, the delivery guide may include one or more radioopaque markers that indicates the location of the distal section of the delivery guide upon radiographic imaging. Usually, the marker will be detected by fluoroscopy.
- The implant itself may be of a shape tailored to achieve a specific purpose. As noted elsewhere, if the purpose of the implant is to provide or to maintain patency of an anatomical structure such as an artery or duct, the implant shape after implantation is itself tubular. The shape may be symmetric or asymmetric, as the purpose dictates.
- Other shapes, including cage structures, may be used to provide patency to vessels or to act as collecting or coralling structures for occlusive members or materials.
- If the purpose or task is to occlude a lumen or open region, the implant may have the form of an occlusive coil that remains helical after deployment or assumes a random orientation.
- In one variation, the implant for placement into a luminal structure is a helical scaffold, e.g., a stent, but any scaffold shape that maintains patency of a lumen may be used. The stents are typically self-expanding stents, such as described in U.S. Pat. No. 4,768,507 to Fishell et al., U.S. Pat. No. 4,990,155 to Wilkoffet al., and U.S. Pat. No. 4,553,545 to Maass et al. In another variation, the implant is an occlusive member, e.g., an occlusive coil, such as described in U.S. Pat. No. 5,334,210 to Gianturco and U.S. Pat. No. 5,382,259 to Phelps et al.
- The interior and exterior surfaces of the implant may be designed to prevent the activation of pathological processes during or after implant deployment. For example, in the case of a vascular stent, the exterior stent surface may be formed to be smooth to decrease the likelihood of intimal damage upon stent release (which would trigger the inflammatory process and attract atheromatous plaque-forming cells). The interior stent surface may also be smooth to minimize turbulent flow through the stent and decrease the risk of stent thrombosis.
- Important physical properties of the implant to consider include, but are not limited to: length, (stent) diameter in the expanded state, degree of flexibility and lateral stiffness, and the like. These physical properties will be modified to account for such factors as lumen diameter, length of any stenosis, type of luminal structure, or solid organ or tissue involved.
- Metals such as stainless steel and tantalum, or metal alloys such as alloys of nickel and titanium, specifically including superelastic alloys such as NITINOL or Elgiloy which are commonly used by those of skill in the art, may be used to form the implants. However, the implants may also be made from biodegradable polymers, e.g., copolymers of lactic and glycolic acid, or nonbiodegradable polymers, e.g., copolymers of ethylene and vinyl acetate.
- The implants may also include a therapeutic agent. Examples of therapeutic agents that may be used in the implants include, but are not limited to, antibiotics, anticoagulants, antifungal agents, anti-inflammatory agents, antineoplastic agents, antithrombotic agents, endothelialization promoting agents, free radical scavengers, immunosuppressive agents, thrombolytic agents, and any combination thereof. If the implant is a stent, an antithrombotic agent is preferably included.
- Examples of selective antithrombotic agents include acetylsalicylic acid, argatroban, cilostazol, copidogrel, cloricromen, dalteparin, daltroban, defibrotide, dipyridamole, enoxaparin, epoprostenol, indobufen, iloprost, integrelin, isbogrel, lamifiban, lamoparan, nadroparin, ozagrel, picotamide, plafibride, reviparin sodium, ridogrel, sulfinpyrazone, taprostene, ticlopidine, tinzaparin, tirofiban, triflusal, and any of their derivatives.
- The therapeutic agent may be coated onto the implant, mixed with a biodegradable polymer or other suitable temporary carrier and then coated onto the implant, or, when the implant is made from a polymeric material, dispersed throughout the polymer.
- The implant may include a radioactive material. The radioactive material may be selected on the basis of its use. For instance, the material may be included in an implant where the implant is in the form of a stent that is to be situated over a vascular stenosis. The radioactivity lowers the incidence of re-stenosis. Additionally, the radioactivity may serve the function of a tracer, to allow detection of the location of the implant during the procedure or anytime thereafter. Suitable radioactive tracers include isotopes of gallium, iodine, technetium, and thallium.
- In one variation of the generic implant delivery system, as shown in FIG. 1A, the implant delivery system includes a
delivery guide 100.Delivery guide 100 has aproximal section 102 and adistal section 104. An implant, in this case depicted as astent 106, surrounds a portion of thedistal section 104 of the delivery guide, and is releasably attached to thedistal section 104 of the delivery guide. Theimplant 106, as shown in FIG. 11B, is concentrically adjacent to thedelivery guide 100. Although I show the stent in FIGS. 1A and 1B as the implant (106), I depict it in this fashion solely for the illustrative purpose of indicating the siting of theimplant 106 on thedelivery guide 100 with the distal and proximal implant release mechanism (109, 111). Various implant release mechanisms or structures are discussed in greater detail below. -
Implant 106 is shown to be directly attached to, is contiguous to, thedelivery guide 100 at theproximal end 108 of the implant and distal end 110 of the implant. In the system shown in FIG. 1A,implant 106 may be secured to thedelivery guide 100 by such generic controllably releasable mechanisms as mechanical, thermal, hydraulic, and electrolytic mechanisms, or a combination thereof. Examples of these release mechanisms will be discussed below. - Consequently, release of the
implant 106 from thedelivery guide 100 may be achieved through a mechanical detachment process involving, e.g., twisting of the delivery guide, such as described by Amplatz in U.S. Pat. No. 6,468,301, or translational movement of the delivery guide in relation to the implant. Implant release may also be achieved using a thermally detachable joint, such as described in U.S. Pat. No. 5,108,407 to Geremia et al., an electrolytic detachable joint, such as described in U.S. Pat. Nos. 5,122,136 and 5,354,295, both to Gulglielmi et al., or a combination thereof. - In another variation, and as shown in FIG. 2, the system includes a
tubular member 200 co-axially mounted on adelivery guide 202.Tubular member 200 may form a component of thedelivery guide 202 that cooperates with one or more of the releasable mentioned joints on the implant (209, 211) to release those joints (and therefore, release the implant 204) upon application of a releasing movement, axial or twisting. An implant, e.g., astent 204, is mounted on adistal section 206 of the delivery guide and thedistal end 208 of the tubular member is attached to theproximal end 210 of the stent. The distal end 212 of the stent is attached using a releasable joint 211 to thedistal section 206 of thedelivery guide 202. - As mentioned above, I may use a tubular member mounted coaxially about the delivery guide, that slides axially about that delivery guide, as a actuator to release the implant. The outer tubular member may also be used to pre-position the implant. For instance, prior to release, the outer tubular member may be used to expand the implant to therefore obscure its placement, and so to permit adjustment of the placement. FIG. 3A shows a
stent 300 expanding astubular member 302 is moved distally on thedelivery guide 304, in the direction of the arrow. The stent is then released from the delivery guide. Specifically, thedistal end 306 of the stent is released from adistal section 308 of the delivery guide, followed by release of theproximal end 310 of the stent from thedistal end 312 of the tubular member. As mentioned above, thestent 300 may be secured to adistal section 308 of the delivery guide by such mechanisms as lock and key arrangements, biocompatible adhesives, soldering, or a combination thereof. Consequently, stent release may be achieved through a mechanical detachment process, a thermal detachment process (e.g., by heat produced from an exothermic reaction), an electrolytic detachment process, or a combination thereof. - FIGS. 3B and 3C show yet another variation of a stent release mechanism. In FIG. 3B,
brackets 314 may be used to couple thestent 300 to thedistal section 308 of the delivery guide. Separation of thestent 306 from thebrackets 314, e.g., by one of the detachment processes mentioned above, releases thedistal end 306 of the stent from adistal section 308 of the delivery guide, allowing the stentdistal end 306 to expand in the tubular organ. - Controllable release of an end of an implant from the delivery guide may be accomplished using the structure of FIG. 3C1.
Brackets 314 couple the stentproximal end 310 to thedistal region 312 of thetubular member 313 that forms a portion of the delivery guide. Thebrackets 314 have a rampedregion 316 which are proximally adjacent to an enlarged (and perhaps ball- or barrel-shaped)portion 318 of the delivery guide andbracket arms 320. The delivery guide and stent each have a delivery diameter, and these delivery diameters may be substantially equal prior to release of the stent. When theactuator 305 is moved proximally, as shown by the direction of the arrow, the ball-shapedportion 318 forces the rampedregions 316 of the brackets outward from the delivery guide axis, in a radial fashion, causing thebracket arms 320 to be displaced radially outwardly from theproximal end 310 of the stent, thereby releasing the stentproximal end 310. - FIG. 3C2 shows the results of moving the
actuator 305 proximally. The clips (316) have rotated as shown due to the force exerted upon the ramps (317) by the ball (318). The implant (320) has expanded in diameter from that found in its undelivered form. - The actuator may be attached, perhaps with a distal radioopaque coil or directly, to a distal section (not shown) of the guide member.
- FIG. 3D1, shows a
delivery system 319 in which the two ends of theimplant 321 may be independently deployed by using anactuator 304 having a proximal releasingball 322 and a distal releasingball 327. Theimplant 321 is located in a gap between sections of the delivery guide and are releasably attached to the delivery guide by brackets or clips. The two balls are spaced in such a way that, in the variation shown in FIG. 3D1, thedistal ball 327 releases thedistal end 331 ofimplant 321 and theproximal ball 322 then releases theproximal end 329 ofimplant 321 upon additional proximal movement ofactuator 304. This sequence of events is shown in FIGS. 3D1, 3D2, and 3D3. Theimplant 321, is shown to be completely released in FIG. 3D3. In this variation, theimplant 321 may be self-expanding, e.g., constructed of a superelastic alloy such as nitinol or another alloy having high elasticity, e.g., an appropriate stainless steel. - A structure similar to that shown in FIGS. 3D1, 3D2, and 3D3 may also be used to deploy an implant using fluid pressure as the releasing impetus.
- FIGS. 3E1, 3E2, 3E3 and 3E4 show a hydraulic variation. Shown are the
delivery guide 350, having ahollow lumen 352, a self-expanding implant 354 (shown variously as non-expanded (e.g., in a “first form”) in FIG. 3E1, partially expanded in FIG. 3E2, and fully expanded in FIGS. 3E3 and 3E4 (e.g., in a “second form”)), and anactuator 356 with a sealingmember 358 and a radio-opaque member 360. - The implant354 (here shown to be a stent or the like) is held to the
delivery guide 350 during delivery to the selected treatment site usingdistal brackets 364 andproximal brackets 362 or clips or the like. The proximal and distal brackets (364, 362) either include regions that cooperate with the fluid inlumen 352 to move upon application of increased pressure in thatlumen 352 and release theimplant 350 or move in concert with a separate pressure sensitive motion component. - FIG. 3E1 shows the
actuator 356 as the sealingmember 358 approaches the various orifices or openings (proximal orifices 366 and distal orifices 368) communicating from thelumen 356 to the hydraulically or fluidly actuatable clips or retaining brackets (proximal brackets 362 and distal brackets 364). - Included in the description of this variation is a radio-
opaque marker 360 on theactuator shaft 356 that allows the user to simply line up thatactuator marker 360 with a corresponding radio-opaque marker 370 or thedelivery guide 350, increase the pressure in lumen 352 (via syringe, pump, etc.) and deploy theproximal end 371 ofimplant 354. The interior pressure raises or rotates the proximal clips orbrackets 362 and moves them out of contact with theimplant 354. FIG. 3E2 shows the movement of the proximal end ofimplant 354 away from thedelivery guide 350. - FIG. 3E3 shows the axial movement of
actuator 356 distally to a position where the sealingmember 358 is positioned to actuate distal clips orbrackets 364 and release the distal end of implant. Again, a radio-opaque marker 374 (perhaps with an additional identification band 376) has been depicted to show alignment of the radio-opaque marker orband 360 on theactuator shaft 356 prior to the increase in pressure for deployment. - FIG. 3E4 shows final deployment at the
implant 354 and proximal movement at theactuator 356, just prior to withdrawal of thedelivery guide 350. The distal and proximal clips or brackets (362, 364) have relaxed to the surface of thedelivery guide 350. - Alternatives to certain of the elements shown in the variation found in FIGS. 3E1 to 3E4 is seen in FIGS. 3F1 and 3F2 and includes, e.g., a
cover element 380 to block or coverproximal orifices 366 during the pressurization of thedistal orifices 368. Thecover element 380 includesholes 382 to allow fluid flow past thecover element 380. - FIG. 3G, shows a variation of the described system in which an implant or
stent 371 is maintained in position on ahollow delivery guide 373 usingspring clips 375 proximally and 377 distally. The spring clips hold theimplant 371 in place during delivery and againstguide member 373. Anactuator 379 is used to remove theclips implant 371 in an independent fashion.Clips guide member 373 for later removal with that guide member. The system shown in FIGS. 3G1, 3G2 and 3G3 may be used to deliver a number of implants in a sequential fashion. Since the retainer clips 375, 377 remain within theguide member 373 after delivery, theactuator 379 is able to slide past the site onguide member 373 where theclips implant 371 deployment, down to and distally to a site on the guide member having another implant for subsequent delivery. Consequently, an arrangement such as this may be used to deploy, in a sequential fashion, a number of stents or the like without withdrawal of the guide member. - In the variation shown in FIGS. 3G1, 3G2 and 3G3, the
clips lumen 381 of theguide member 373 once they are pushed into therespective slots 383 provided for such retraction. Such spring loaded clips retain the self expanding stent orimplant 371 onto the face ofguide member 373. Each ofclips hook members implant 371, often axially stretching theimplant 371 and maintaining the delivery radius of theimplant 371 as shown. - As shown in FIG. 3G1,
actuator 379 is pushed distally along the outer surface ofguide member 373 until it contacts the proximal end ofclip 375. Further distal movement ofactuator 379 urges clip 375 intolumen 381 thereby rotatinghorn 387 out of cooperating receptacle area inimplant 371. - FIG. 3G2 shows the results of such movement after
clip 375 has completed its springed closure withinlumen 381. As shown in that Figure, the proximal end ofimplant 371 has expanded and yet the distal end ofimplant 371 remains closed and hooked todistal clip 377. This semi-open condition allows for some adjustment of the implant if needed. FIG. 3G3 shows the results of additional distal movement ofactuator 379 until it contacts distal clip 377 (shown in FIG. 3G3 in its collapsed form ) and thereby allowing the distal end ofimplant 371 to self-expand into the chosen treatment site. - FIG. 3G3 shows that
guide member 379 is free.Implant 371 is shown in its self expanded form no longer adjacent thecentral guide member 379.Actuator 379 is situated withinimplant 371 and is no longer in contact withproximal clip 375 nordistal clip 377.Actuator 379 is thus able to continue distally to another implant containing site positioned in a more distal site on theguide member 373. - The mechanical variation shown in FIGS. 3G1, 3G2, 3G3 may be modified in such a way that the actuator is interior to the lumen of the guide member and deploys the implant upon distal movement of the actuator by providing an actuator with a slot or other “room-making” provisions in the actuator. The actuator and any retained clips would then be used to actuate the clips in the next more distal implant if so desired.
- In yet a further variation, the system releases an implant (shown as a stent404 in FIG. 4) attached to a
delivery guide 400 by one ormore attachment arms 402 positioned, e.g., at the implant proximal and distal ends, by sliding atubular member 406, mounted co-axially on thedelivery guide 400, distally over thedelivery guide 400. The stent 404 is secured to thedelivery guide 400 when theattachment arms 402 are in a radially expanded configuration (as illustrated in FIG. 4). Thetubular member 406 urges theattachment arms 402 into a compressed configuration as it slides distally over thedelivery guide 400, in the direction of the arrow. When theattachment arms 402 are compressed by thetubular member 406, they are moved inward from the stent 404, toward the central axis of thedelivery guide 400, thereby releasing the stent 404 from thedelivery guide 400. Stent detachment occurs in a serial fashion as thetubular member 406 is moved distally, with detachment of the stent proximal end 408 occurring before detachment at the stent distal end 410. Consequently, if the stent position requires readjustment after detachment of the stent proximal end, the stent may be repositioned prior to detaching the stent distal end. In one variation, the tubular member is a balloon catheter. - The
attachment arms 402 are generally made from the same materials as thedelivery guide 400, e.g., stainless steel or nickel-titanium alloy, and will typically have a length, thickness, shape, and flexibility appropriate for its intended mechanism of release. The distal ends 412 of the attachment arms may be of any design, so long as one or more of them, when in a radially expanded configuration, secures a portion of a stent to a delivery guide, and when in a compressed configuration, releases that same stent portion from the delivery guide. - The tubular member may be a thin-walled tube (e.g., approximately 0.005 cm (0.002 inches) in thickness) with an outside diameter ranging from about 0.025 cm to about 0.139 cm (0.010 inches to about 0.055 inches), more usually from about 0.025 cm to about 0.05 cm (0.010 inches to about 0.020 inches), and more usually still from about 0.025 cm to about 0.035 cm (0.010 inches to about 0.014 inches). Depending on such factors as degree of flexibility or durometer required, they may be made from various metals or metal alloys, including, but not limited to, stainless steel and nickel-titanium alloy, or from various polymers, such as polyvinyl chloride, polyethylene, polyethylene terephthalate, and polyurethane.
- FIGS. 5A, 5B, and5C show a variation of the described
delivery system 500 in which a member of electrolytic delivery joints are used to deploy animplant 502, such as a stent. - The electrolytic delivery joints shown here (e.g.,504 in FIG. 5C) are well known as controllable delivery joints for placement of vaso-occlusive coils. One such commercially available device using an electrolytically detachable joint is sold by Target Therapeutics, a subsidiary of Boston Scientific Corp., as the Guglielmi Detachable Coil (or “GDC”). Numerous patents to Dr. Guglielmi describe the theory of its use.
- In essence, the electrolytically erodible joint is a section of an electrical circuit that is not insulated and is of a metallic material that does not form insulating oxides when exposed to an aqueous environment (e.g., aluminum and tantalum) and is sufficiently “non-noble” that is will either electrolytically erode by ionic dissolution into an anatomical fluid or, perhaps, electrochemically erode by forming readily soluble oxides or salts.
- The erodible joint504 shown in FIG. 5C is a bare metal of a size, diameter, etc. that erodes away when a current is applied to insulated
wire 506. The current flow is from a power supply through insulatedwire 506, bare joint 504, into the ionic anatomical fluid surrounding the site to be treated, and back to a return electrode situated perhaps on the patient's skin and then back to the power supply. The current flows through the circuit so long as the joint 504 exists. - With that background, FIG. 5A shows a device having several joints (504, 508, 510, 512) that each may be independently severed to controllably deploy the
implant 502.Implant 502 is shown having coils (514, 516) that are terminated at each end by an erodible joint and that, prior to the severing of a joint, hold thisimplant 502 to the surface of thedelivery member 520. Theimplant 500 is self-expanding, once released. The wires forming the two coils in this variation slide within the implant or “uncoil” and thereby allow the implant body itself to expand. The coils may comprise (if electrically connected to the erodible joint) a metal that is higher in the Mendelev Electromotive Series than is the composition at the electrolytic joint or the coils may comprise a polymer that may be bio-erodible or not. - In any case, a suitable way to assure that the coils (514, 516) maintain the low profile of the
implant 502 during delivery is via the placement of the various conductive wires (506, 516, 518, 520) through the adjacent holes (524, 526, 528) and fill the holes with e.g., an epoxy to hold all in place. Independently causing current to flow through each of the joints will release the implant in the region of the released joint Once all joints are eroded, the implant is released. - Although release from proximal and distal ends of the tubular form of the implants has been described, detachment from a delivery guide is not so limited. In another variation, the stent is attached to the delivery guide at one or more positions along the length of the stent, in addition to attachment at the proximal and distal implant ends. Once the distal stent end is released, the additional attachments may be independently released until detachment at the proximal implant end releases the implant entirely from the delivery guide. Serial release may provide better control of positioning in tubular organs.
- FIGS. 5D and 5E show in more detail, the components of an electrolytic joint (as may be found in FIGS. 5A, 5B and5C) and another electrically actuated joint using a meltable or softenable or polymerically sizable joint
- FIG. 5D shows the
insulated wire 524 with insulation 523 andconductor 525. The electrolytic joint 504 is also shown. In this variation, thewire 524 is shown to be secured into thedelivery guide wall 520 by, e.g., an epoxy 527, an alternative or cooperative band orcomponent 529 holding thewire 524 to the surface ofguide member 520 is also shown. After erodable joint 504 is eroded, the implant of 502 expands and leaves thesecurement band 529 on thedelivery guide 520. - FIG. 5E shows a similar variation but the joint comprises a thermoplastic adhesive or
shape changing polymer 531 situated on the end ofwire 525 and within a cup orother receptacle 533. The adhesive is of the type that changes form or viscosity upon application of current to the joint. In this variation, the thermoplastic is rendered conductive, but resistive, by introduction of material such as carbon black into the polymeric adhesive. As soon as the polymer changes its shape, form, or phase, the implant expands to the desired form about thecentral guide member 520 again, the wire may be held in place with an adhesive 527 if so desired. - Although the figures show wires and other remnants of the joints remaining exterior to the
central guide member 520 and the others shown and described here, it is desirable that these not be situated in such a way that they will harm the tissues into which they are placed. - The implant delivery devices described herewith may include multiple implants on a single delivery guide or may be used in conjunction with other instruments, as seen appropriate, to treat the target site. In general, the tubular organ of interest is percutaneously accessed, but the method of accessing will usually be dependent on the anatomy of the organ, medical condition being treated, health status of the subject, and the like. Consequently, access by a laparoscopic or open procedure may also be obtained.
- FIGS. 6A-6D show the general method of deploying a stent using my described system. After obtaining access to the tubular organ of interest600 (blood vessel in FIG. 6A), a
delivery guide 602 is placed through the selected area ofstenosis 604 at the target site. Aballoon catheter 606 is then advanced over thedelivery guide 602, and balloon angioplasty performed to dilate the area of stenosis 604 (FIG. 6B). Theballoon catheter 606 is then retracted proximally and thedelivery guide 602 exchanged for a stent delivery device 608 (FIG. 6C). Appropriate placement of the stent is guided byradioopaque markers 616 on thedelivery guide 612. Thedistal end 610 of the stent is then released from thedelivery guide 612. At this point, stent position may again be checked by verifying the location of the radioopaque markers. Theproximal stent end 614 is then released from thedelivery guide 612. - If desired, an embolic filter may be used during stent deployment to filter any debris generated during the procedure. The filter will usually be attached to the delivery guide such that it filters debris distal to the stent, but may also be attached to the delivery guide proximal to the stent, or both distal and proximal to the stent. The filter may be of any design, as long as it does not affect the substantially atraumatic, low profile, and controlled release characteristics of the stent delivery device. Typically, the filter is basket-shaped, and made from a shape-memory material, e.g., an alloy of titanium and nickel. The filter will usually be contained within the balloon catheter lumen, and deployed to its pre-designed shape once the balloon catheter is removed. Following placement of the stent, the balloon catheter may be advanced over the delivery guide to enclose the filter with any accumulated debris. The balloon catheter, filter, and delivery guide may then be removed from the body.
- The implant delivery system may be used in mammalian subjects, preferably humans. Mammals include, but are not limited to, primates, farm animals, sport animals, cats, dogs, rabbits, mice, and rats.
- The system may be employed for implant delivery into lumens of tubular organs including, but not limited to, blood vessels (including intracranial vessels, large vessels, peripheral vessels, aneurysms, arteriovenous malformations, arteriovenous fistulas), ureters, bile ducts, fallopian tubes, cardiac chambers, ducts such as bile ducts and mammary ducts, large and small airways, and hollow organs, e.g., stomach, intestines, and bladder. The system may also be employed for implant delivery into solid organs or tissues including, but not limited to, skin, muscle, fat, brain, liver, kidneys, spleen, and benign and malignant tumors. Preferably, the implant is delivered to a target site in a blood vessel lumen.
- Clinically, the system may generally be used to treat stenosis of various tubular organs, arising from such etiologies as atherosclerosis, autoimmune conditions, scarring, or exterior compression, e.g., as may be seen with a neoplastic process. The system may also be used to treat medical conditions in which luminal occlusion is desired, e.g., to treat aneurysms, arteriovenous fistulas, and arteriovenous malformations. Furthermore, the system may be employed to deliver implants into such areas as joint spaces, spinal discs, and the intraperitoneal or extraperitoneal spaces.
- All publications, patents, and patent applications cited herein are hereby incorporated by reference in their entirety for all purposes to the same extent as if each individual publication, patent, or patent application were specifically and individually indicated to be so incorporated by reference. Although the foregoing invention has been described in some detail by way of illustration and example for purposes of clarity of understanding, it will be readily apparent to those of ordinary skill in the art in light of the teachings of this invention that certain changes and modifications may be made thereto without departing from the spirit and scope of the appended claims.
Claims (55)
1.-21. (Cancelled, without prejudice)
22. The system of claim 24 wherein the implant exterior surface is smooth after deployment.
23. The system of claim 24 wherein the implant interior surface is smooth after deployment.
24. A implant delivery system comprising:
an elongate delivery guide member having a proximal end and a distal end, the delivery guide member configured to direct at least one implant having an exterior and interior surface to an anatomical treatment site by manipulation by a user,
the at least one implant having a delivery diameter prior to release of the at least one implant and located proximally of the distal end of the delivery guide member prior to release, and
a plurality of releasable joints, each joint configured to maintain a section of the at least one implant at the delivery diameter until release of the releasable joints, wherein the system is adapted for sequential release of the releasable joints.
25. The system of claim 24 wherein the delivery guide member is closed at its distal end.
26. The system of claim 24 wherein the delivery guide member has a diameter distally and proximally of the at least one implant that is substantially equal to the at least one implant delivery diameter, whereby a substantially atraumatic implant delivery system is provided.
27. The system of claim 24 wherein the delivery guide member has no passageway from its proximal to its distal end.
28. The system of claim 24 further comprising an actuator for releasing the releasable joints, and wherein the delivery guide member has only a single passageway from its proximal to its distal end, that passageway contains the actuator, and that actuator does not extend beyond the distal end of the delivery guide member.
29. The system of claim 28 wherein the actuator for releasing the releasable joints is affixed to the distal end of the delivery guide member.
30. The system of claim 24 wherein the at least one implant comprises exactly one implant.
31. The system of claim 24 wherein the at least one implant comprises more than one implant.
32. The system of claim 24 wherein the delivery guide member comprises a distal guide section and a proximal guide section and a gap between the distal guide section and the proximal guide section and the at least one implant is located between the distal guide section and the proximal guide section.
33. (Cancelled, without prejudice)
34. The system of claim 24 wherein the delivery guide member is tubular in form, having a lumen therein.
35. The system of claim 34 further comprising an actuator slidably located at least partially within the delivery guide member lumen and configured to release at least one releasable joint upon axial movement within the delivery guide member.
36, 37. (Cancelled, without prejudice).
38. The system of claim 34 further comprising an actuator slidably located at least partially within the delivery guide member lumen and configured to release at least one releasable joint upon rotational movement within the delivery guide member.
39. The system of claim 34 wherein at least one releasable joint is configured to release upon application of fluid pressure in the delivery guide member lumen and further comprising a fluid director slidably located at least partially within the delivery guide member lumen and configured to direct fluid to and to release that selected at least one releasable joint.
40. The system of claim 39 wherein the fluid director is configured to sequentially release the plurality of releasable joints upon application of fluid pressure in the delivery guide member lumen.
41. The system of claim 34 wherein the releasable joints are configured to release upon application of a suitable DC current to the releasable joints, the system further comprising an electrical conductor located at least partially within the delivery guide member lumen to supply the suitable DC current to and to thereby release at the releasable joints.
42, 43. (Cancelled, without prejudice)
44. The system of claim 24 wherein the implant is a stent.
45. The system of claim 44 wherein the stent is unsheathed.
46. The system of claim 24 wherein the implant is an occlusive coil.
47. The system of claim 24 wherein the implant further comprises a therapeutic agent.
48. The system of claim 47 wherein the therapeutic agent is selected from the group consisting of antibiotics, anticoagulants, antifungal agents, anti-inflammatory agents, antineoplastic agents, antithrombotic agents, endothelialization promoting agents, free radical scavengers, immunosuppressive agents, thrombolytic agents, and combinations thereof.
49. The system of claim 24 wherein the delivery guide member further comprises a radioopaque marker.
50. The system of claim 24 having flexibility and remote directability, wherein the remote directability is such that a user may direct the distal end of the delivery guide member into and introduce the at least one implant into a coronary artery solely by manipulation of the delivery guide member from its proximal end.
51.-75. (Cancelled, without prejudice)
76. A system for treating a target site in a tubular organ comprising:
the implant delivery system of any one of claims 22-32, 34, 35, 38-41 or 44-50; and
a balloon catheter.
77. The system of claim 76 further comprising an embolic filter.
78. The system of claim 77 wherein the embolic filter is attached to the proximal end of the delivery guide member.
79. The system of claim 76 wherein the implant is a stent.
80. The system of claim 76 wherein the implant is an occlusive coil.
81. A method for delivering an implant in a subject comprising:
accessing a body region;
advancing an implant delivery guide to a target site in the body region; and
releasing the implant at the target site by releasing one portion of the implant after another in a sequential fashion.
82. The method of claim 81 further comprising deploying at least one embolic filter.
83. The method of claim 81 wherein the releasing comprises releasing a distal end of the implant from the delivery guide before releasing a proximal end of the implant from the delivery guide.
84. The method of claim 81 wherein the releasing comprises a mechanical detachment process.
85. The method of claim 81 wherein the releasing comprises a hydraulic detachment process.
86. The method of claim 81 wherein the releasing comprises an electrolytic detachment process.
87. The method of claim 81 wherein the body region is a tubular or hollow organ.
88. The method of claim 87 wherein the tubular or hollow organ is selected from the group consisting of blood vessels, arteriovenous malformations, aneurysms, arteriovenous fistulas, cardiac chambers, bile ducts, mammary ducts, fallopian tubes, ureters, large and small airways, stomach, intestines, and bladder.
89. The method of claim 81 wherein the body region is a blood vessel.
90. The method of claim 81 wherein the implant is a stent.
91. The method of claim 81 wherein the implant is an occlusive coil.
92. The method of claim 81 wherein the target site comprises an aneurysm.
93. The method of claim 81 wherein the subject is human.
94. The method of claim 81 wherein the accessing is performed percutaneously.
95. The method of claim 81 wherein the stent implant delivery system is selected from those described in any one of claims 22-32, 34, 35, 38-41, 44-50 or 76-80.
96. The method of claim 81 further comprising:
advancing a balloon catheter to the target site;
performing angioplasty with the balloon catheter prior to the releasing of the implant.
97. The system of claim 25 , wherein an atraumatic tip provides the end closure
98. The system of claim 24 wherein the delivery guide member has a distal diameter between about 0.010 and about 0.020 inches, whereby a low-profile delivery system is provided.
99. The system of claim 24 wherein the delivery guide member is noninflatable.
100. The system of claim 24 wherein the system is guidewireless.
101. The system of claim 25 , wherein an atraumatic tip provides the end closure
Priority Applications (12)
Application Number | Priority Date | Filing Date | Title |
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US10/746,452 US20040193178A1 (en) | 2003-03-26 | 2003-12-24 | Multiple joint implant delivery systems for sequentially-controlled implant deployment |
US10/550,707 US7785361B2 (en) | 2003-03-26 | 2004-03-23 | Implant delivery technologies |
AT04758233T ATE467402T1 (en) | 2003-03-26 | 2004-03-23 | IMPLANT DEPOSIT CATHETER WITH ELECTROLYTICALLY DEGRADABLE COMPOUNDS |
EP04758233A EP1608299B1 (en) | 2003-03-26 | 2004-03-23 | Implant delivery catheter with electrolytically erodible joints |
AU2004226464A AU2004226464A1 (en) | 2003-03-26 | 2004-03-23 | Implant delivery technologies |
CA002517823A CA2517823A1 (en) | 2003-03-26 | 2004-03-23 | Implant delivery technologies |
PCT/US2004/008909 WO2004087006A2 (en) | 2003-03-26 | 2004-03-23 | Implant delivery technologies |
ES04758233T ES2346059T3 (en) | 2003-03-26 | 2004-03-23 | IMPLANT SUPPLY CATHETER WITH ELECTROLYTICALLY EROSIONABLE JOINTS. |
JP2006507500A JP2006521161A (en) | 2003-03-26 | 2004-03-23 | Implant delivery technology |
EP10004501A EP2226040A1 (en) | 2003-03-26 | 2004-03-23 | Stent delivery system with torsionally compressed stent |
DE602004027122T DE602004027122D1 (en) | 2003-03-26 | 2004-03-23 | IMPLANT CATHETER WITH ELECTROLYTICALLY REMOVABLE COMPOUNDS |
US11/266,587 US7771463B2 (en) | 2003-03-26 | 2005-11-02 | Twist-down implant delivery technologies |
Applications Claiming Priority (3)
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US45832303P | 2003-03-26 | 2003-03-26 | |
US46221903P | 2003-04-10 | 2003-04-10 | |
US10/746,452 US20040193178A1 (en) | 2003-03-26 | 2003-12-24 | Multiple joint implant delivery systems for sequentially-controlled implant deployment |
Related Parent Applications (1)
Application Number | Title | Priority Date | Filing Date |
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US10/746,455 Continuation-In-Part US20040193179A1 (en) | 2003-03-26 | 2003-12-24 | Balloon catheter lumen based stent delivery systems |
Related Child Applications (3)
Application Number | Title | Priority Date | Filing Date |
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US10/745,778 Continuation-In-Part US8016869B2 (en) | 2003-03-26 | 2003-12-24 | Guidewire-less stent delivery methods |
US11/266,587 Continuation-In-Part US7771463B2 (en) | 2003-03-26 | 2005-11-02 | Twist-down implant delivery technologies |
US11/550,707 Continuation-In-Part US7985178B2 (en) | 2005-10-18 | 2006-10-18 | Endoscope and method for its manufacturing |
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Cited By (57)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20050283183A1 (en) * | 2004-06-21 | 2005-12-22 | Tri Tran | Expanding vaso-occlusive device |
US20070198076A1 (en) * | 2006-02-13 | 2007-08-23 | Stephen Hebert | System for delivering a stent |
US20070299501A1 (en) * | 2002-02-28 | 2007-12-27 | Counter Clockwise, Inc. | Guidewire loaded stent for delivery through a catheter |
WO2008135260A1 (en) * | 2007-05-04 | 2008-11-13 | Micromuscle Ab | Surgical device |
US20090030497A1 (en) * | 2007-07-25 | 2009-01-29 | Metcalf Justin M | Retention Wire For Self-Expanding Stent |
US20090306761A1 (en) * | 2008-06-06 | 2009-12-10 | Bay Street Medical | Prosthesis and delivery system |
US7651521B2 (en) | 2004-03-02 | 2010-01-26 | Cardiomind, Inc. | Corewire actuated delivery system with fixed distal stent-carrying extension |
US20100114291A1 (en) * | 2008-10-31 | 2010-05-06 | William Cook Europe Aps | Introducer for Deploying a Stent Graft in a Curved Lumen and Stent Graft Therefor |
US7771463B2 (en) | 2003-03-26 | 2010-08-10 | Ton Dai T | Twist-down implant delivery technologies |
US7785361B2 (en) | 2003-03-26 | 2010-08-31 | Julian Nikolchev | Implant delivery technologies |
US7862602B2 (en) | 2005-11-02 | 2011-01-04 | Biosensors International Group, Ltd | Indirect-release electrolytic implant delivery systems |
US8016869B2 (en) | 2003-03-26 | 2011-09-13 | Biosensors International Group, Ltd. | Guidewire-less stent delivery methods |
US8147534B2 (en) | 2005-05-25 | 2012-04-03 | Tyco Healthcare Group Lp | System and method for delivering and deploying an occluding device within a vessel |
CN102548504A (en) * | 2009-06-26 | 2012-07-04 | 生物传感器国际集团有限公司 | Implant delivery apparatus and methods with electrolytic release |
US8267985B2 (en) | 2005-05-25 | 2012-09-18 | Tyco Healthcare Group Lp | System and method for delivering and deploying an occluding device within a vessel |
US8273101B2 (en) | 2005-05-25 | 2012-09-25 | Tyco Healthcare Group Lp | System and method for delivering and deploying an occluding device within a vessel |
US8328860B2 (en) | 2007-03-13 | 2012-12-11 | Covidien Lp | Implant including a coil and a stretch-resistant member |
US8382825B2 (en) | 2004-05-25 | 2013-02-26 | Covidien Lp | Flexible vascular occluding device |
US8394119B2 (en) | 2006-02-22 | 2013-03-12 | Covidien Lp | Stents having radiopaque mesh |
US8398701B2 (en) | 2004-05-25 | 2013-03-19 | Covidien Lp | Flexible vascular occluding device |
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US8617234B2 (en) | 2004-05-25 | 2013-12-31 | Covidien Lp | Flexible vascular occluding device |
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US8777978B2 (en) | 2006-04-17 | 2014-07-15 | Covidien Lp | System and method for mechanically positioning intravascular implants |
US8777979B2 (en) | 2006-04-17 | 2014-07-15 | Covidien Lp | System and method for mechanically positioning intravascular implants |
US8801747B2 (en) | 2007-03-13 | 2014-08-12 | Covidien Lp | Implant, a mandrel, and a method of forming an implant |
US20140277356A1 (en) * | 2013-03-12 | 2014-09-18 | Abbott Cardiovascular Systems Inc. | Catheter having hydraulic actuator and locking system |
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US9011480B2 (en) | 2012-01-20 | 2015-04-21 | Covidien Lp | Aneurysm treatment coils |
US9050095B2 (en) | 2004-09-22 | 2015-06-09 | Covidien Lp | Medical implant |
US9114001B2 (en) | 2012-10-30 | 2015-08-25 | Covidien Lp | Systems for attaining a predetermined porosity of a vascular device |
US9144508B2 (en) | 2007-07-19 | 2015-09-29 | Back Bay Medical Inc. | Radially expandable stent |
US9157174B2 (en) | 2013-02-05 | 2015-10-13 | Covidien Lp | Vascular device for aneurysm treatment and providing blood flow into a perforator vessel |
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Families Citing this family (77)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
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US7951185B1 (en) * | 2006-01-06 | 2011-05-31 | Advanced Cardiovascular Systems, Inc. | Delivery of a stent at an elevated temperature |
US7771451B2 (en) * | 2006-04-05 | 2010-08-10 | Boston Scientific Scimed, Inc. | Method and apparatus for the deployment of vaso-occlusive coils |
GB0700560D0 (en) * | 2007-01-11 | 2007-02-21 | Emcision Ltd | Device and method for the treatment of diseased tissue such as tumours |
US8133265B2 (en) * | 2006-06-30 | 2012-03-13 | Olympus Medical Systems Corp. | Guide catheter, and stent delivery system |
US20080051867A1 (en) * | 2006-08-28 | 2008-02-28 | Davila Luis A | Multiple in vivo implant delivery device |
EP3329882B1 (en) | 2006-10-22 | 2023-09-20 | IDEV Technologies, INC. | Methods for securing strand ends and the resulting devices |
MX2009004292A (en) | 2006-10-22 | 2009-08-12 | Idev Technologies Inc | Devices and methods for stent advancement. |
GB2443870B (en) * | 2006-11-09 | 2008-12-24 | Motorola Inc | Content item distribution |
US7963987B2 (en) * | 2007-12-28 | 2011-06-21 | Cook Medical Technologies Llc | Sequential implant delivery system |
EP2271290B1 (en) * | 2008-04-03 | 2017-03-01 | Cook Medical Technologies LLC | Implant release mechanism |
EP2633823B1 (en) | 2008-04-21 | 2016-06-01 | Covidien LP | Braid-ball embolic devices and delivery systems |
CA2731735A1 (en) | 2008-07-22 | 2010-01-28 | Microtherapeutics, Inc. | Vascular remodeling device |
US20100160951A1 (en) * | 2008-12-19 | 2010-06-24 | Madison Michael T | Intracranial blood vessel dilation device |
EP2496189A4 (en) | 2009-11-04 | 2016-05-11 | Nitinol Devices And Components Inc | Alternating circumferential bridge stent design and methods for use thereof |
US9649211B2 (en) | 2009-11-04 | 2017-05-16 | Confluent Medical Technologies, Inc. | Alternating circumferential bridge stent design and methods for use thereof |
US9468442B2 (en) | 2010-01-28 | 2016-10-18 | Covidien Lp | Vascular remodeling device |
US9023095B2 (en) | 2010-05-27 | 2015-05-05 | Idev Technologies, Inc. | Stent delivery system with pusher assembly |
US8864811B2 (en) | 2010-06-08 | 2014-10-21 | Veniti, Inc. | Bi-directional stent delivery system |
US9301864B2 (en) | 2010-06-08 | 2016-04-05 | Veniti, Inc. | Bi-directional stent delivery system |
US9233014B2 (en) | 2010-09-24 | 2016-01-12 | Veniti, Inc. | Stent with support braces |
CN103442653B (en) | 2011-02-11 | 2016-06-01 | 柯惠有限合伙公司 | Two benches launches aneurysma embolization device |
WO2012134990A1 (en) | 2011-03-25 | 2012-10-04 | Tyco Healthcare Group Lp | Vascular remodeling device |
WO2013049448A1 (en) | 2011-09-29 | 2013-04-04 | Covidien Lp | Vascular remodeling device |
EP2628470B1 (en) | 2012-02-16 | 2020-11-25 | Biotronik AG | Release device for releasing a medical implant from a catheter and catheter having a release device and method for clamping an implant therein |
US9072624B2 (en) | 2012-02-23 | 2015-07-07 | Covidien Lp | Luminal stenting |
US20130226278A1 (en) | 2012-02-23 | 2013-08-29 | Tyco Healthcare Group Lp | Methods and apparatus for luminal stenting |
US9078659B2 (en) * | 2012-04-23 | 2015-07-14 | Covidien Lp | Delivery system with hooks for resheathability |
EP2676642A1 (en) * | 2012-06-18 | 2013-12-25 | Biotronik AG | Release device for releasing a medical implant from a catheter |
US9724222B2 (en) * | 2012-07-20 | 2017-08-08 | Covidien Lp | Resheathable stent delivery system |
US9326774B2 (en) | 2012-08-03 | 2016-05-03 | Covidien Lp | Device for implantation of medical devices |
US9314248B2 (en) | 2012-11-06 | 2016-04-19 | Covidien Lp | Multi-pivot thrombectomy device |
US20140135907A1 (en) | 2012-11-09 | 2014-05-15 | Medtronic CV Luxembourg S.a.r.l. | Medical Device Delivery System and Methods of Delivering Medical Devices |
US9295571B2 (en) * | 2013-01-17 | 2016-03-29 | Covidien Lp | Methods and apparatus for luminal stenting |
US9119948B2 (en) * | 2013-02-20 | 2015-09-01 | Covidien Lp | Occlusive implants for hollow anatomical structures, delivery systems, and related methods |
EP2774586B1 (en) * | 2013-03-06 | 2016-11-23 | Cook Medical Technologies LLC | Introducer sheath having a non-uniform inner surface |
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CN108433769B (en) | 2013-03-15 | 2021-06-08 | 柯惠有限合伙公司 | Occlusion device |
JP2014233592A (en) * | 2013-06-05 | 2014-12-15 | 朝日インテック株式会社 | Pusher guide wire |
US10130500B2 (en) | 2013-07-25 | 2018-11-20 | Covidien Lp | Methods and apparatus for luminal stenting |
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US9782186B2 (en) | 2013-08-27 | 2017-10-10 | Covidien Lp | Vascular intervention system |
US9814466B2 (en) | 2014-08-08 | 2017-11-14 | Covidien Lp | Electrolytic and mechanical detachment for implant delivery systems |
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JP2018532532A (en) | 2015-10-14 | 2018-11-08 | スリー リバーズ メディカル インク.Three Rivers Medical Inc. | Mechanical embolic delivery device and method |
US9968360B2 (en) | 2016-05-31 | 2018-05-15 | Spartan Micro, Inc. | Systems and methods for delivering intravascular implants |
US10828037B2 (en) | 2016-06-27 | 2020-11-10 | Covidien Lp | Electrolytic detachment with fluid electrical connection |
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US11051822B2 (en) | 2016-06-28 | 2021-07-06 | Covidien Lp | Implant detachment with thermal activation |
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WO2022266378A1 (en) * | 2021-06-17 | 2022-12-22 | Starlight Cardiovascular, Inc. | Ductus arteriosus and septal conduit implants and related delivery systems and methods |
US11944558B2 (en) | 2021-08-05 | 2024-04-02 | Covidien Lp | Medical device delivery devices, systems, and methods |
Citations (93)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US625628A (en) * | 1899-05-23 | Combined mop and brush holder | ||
US4733665A (en) * | 1985-11-07 | 1988-03-29 | Expandable Grafts Partnership | Expandable intraluminal graft, and method and apparatus for implanting an expandable intraluminal graft |
US4830003A (en) * | 1988-06-17 | 1989-05-16 | Wolff Rodney G | Compressive stent and delivery system |
US4990155A (en) * | 1989-05-19 | 1991-02-05 | Wilkoff Howard M | Surgical stent method and apparatus |
US4990151A (en) * | 1988-09-28 | 1991-02-05 | Medinvent S.A. | Device for transluminal implantation or extraction |
US4998539A (en) * | 1987-12-18 | 1991-03-12 | Delsanti Gerard L | Method of using removable endo-arterial devices to repair detachments in the arterial walls |
US5019090A (en) * | 1988-09-01 | 1991-05-28 | Corvita Corporation | Radially expandable endoprosthesis and the like |
US5089006A (en) * | 1989-11-29 | 1992-02-18 | Stiles Frank B | Biological duct liner and installation catheter |
US5092877A (en) * | 1988-09-01 | 1992-03-03 | Corvita Corporation | Radially expandable endoprosthesis |
US5102417A (en) * | 1985-11-07 | 1992-04-07 | Expandable Grafts Partnership | Expandable intraluminal graft, and method and apparatus for implanting an expandable intraluminal graft |
US5108416A (en) * | 1990-02-13 | 1992-04-28 | C. R. Bard, Inc. | Stent introducer system |
US5123917A (en) * | 1990-04-27 | 1992-06-23 | Lee Peter Y | Expandable intraluminal vascular graft |
US5192297A (en) * | 1991-12-31 | 1993-03-09 | Medtronic, Inc. | Apparatus and method for placement and implantation of a stent |
US5201757A (en) * | 1992-04-03 | 1993-04-13 | Schneider (Usa) Inc. | Medial region deployment of radially self-expanding stents |
US5372600A (en) * | 1991-10-31 | 1994-12-13 | Instent Inc. | Stent delivery systems |
US5382259A (en) * | 1992-10-26 | 1995-01-17 | Target Therapeutics, Inc. | Vasoocclusion coil with attached tubular woven or braided fibrous covering |
US5405378A (en) * | 1992-05-20 | 1995-04-11 | Strecker; Ernst P. | Device with a prosthesis implantable in the body of a patient |
US5484444A (en) * | 1992-10-31 | 1996-01-16 | Schneider (Europe) A.G. | Device for the implantation of self-expanding endoprostheses |
US5486195A (en) * | 1993-07-26 | 1996-01-23 | Myers; Gene | Method and apparatus for arteriotomy closure |
US5507771A (en) * | 1992-06-15 | 1996-04-16 | Cook Incorporated | Stent assembly |
US5725551A (en) * | 1993-07-26 | 1998-03-10 | Myers; Gene | Method and apparatus for arteriotomy closure |
US5725549A (en) * | 1994-03-11 | 1998-03-10 | Advanced Cardiovascular Systems, Inc. | Coiled stent with locking ends |
US5733267A (en) * | 1995-04-05 | 1998-03-31 | Scimed Life Systems, Inc. | Pull back stent delivery system |
US5873907A (en) * | 1998-01-27 | 1999-02-23 | Endotex Interventional Systems, Inc. | Electrolytic stent delivery system and methods of use |
US5891128A (en) * | 1994-12-30 | 1999-04-06 | Target Therapeutics, Inc. | Solderless electrolytically severable joint for detachable devices placed within the mammalian body |
US6015429A (en) * | 1994-09-08 | 2000-01-18 | Gore Enterprise Holdings, Inc. | Procedures for introducing stents and stent-grafts |
US6019779A (en) * | 1998-10-09 | 2000-02-01 | Intratherapeutics Inc. | Multi-filar coil medical stent |
US6019737A (en) * | 1997-03-31 | 2000-02-01 | Terumo Kabushiki Kaisha | Guide wire |
US6027520A (en) * | 1997-05-08 | 2000-02-22 | Embol-X, Inc. | Percutaneous catheter and guidewire having filter and medical device deployment capabilities |
US6027516A (en) * | 1995-05-04 | 2000-02-22 | The United States Of America As Represented By The Department Of Health And Human Services | Highly elastic, adjustable helical coil stent |
US6042605A (en) * | 1995-12-14 | 2000-03-28 | Gore Enterprose Holdings, Inc. | Kink resistant stent-graft |
US6042588A (en) * | 1998-03-03 | 2000-03-28 | Scimed Life Systems, Inc | Stent delivery system |
US6042589A (en) * | 1998-03-17 | 2000-03-28 | Medicorp, S.A. | Reversible-action endoprosthesis delivery device |
US6053940A (en) * | 1995-10-20 | 2000-04-25 | Wijay; Bandula | Vascular stent |
US6068634A (en) * | 1996-08-23 | 2000-05-30 | Scimed Life Systems, Inc. | Stent delivery system |
US6168616B1 (en) * | 1997-06-02 | 2001-01-02 | Global Vascular Concepts | Manually expandable stent |
US6168579B1 (en) * | 1999-08-04 | 2001-01-02 | Scimed Life Systems, Inc. | Filter flush system and methods of use |
US6183481B1 (en) * | 1999-09-22 | 2001-02-06 | Endomed Inc. | Delivery system for self-expanding stents and grafts |
US6200305B1 (en) * | 1998-09-30 | 2001-03-13 | Medtronic Ave, Inc. | Catheter having a variable length shaft segment and method of use |
US6203550B1 (en) * | 1998-09-30 | 2001-03-20 | Medtronic, Inc. | Disposable delivery device for endoluminal prostheses |
US6214036B1 (en) * | 1998-11-09 | 2001-04-10 | Cordis Corporation | Stent which is easily recaptured and repositioned within the body |
US6221097B1 (en) * | 1999-03-22 | 2001-04-24 | Scimed Life System, Inc. | Lubricated sleeve material for stent delivery |
US6221081B1 (en) * | 1998-09-14 | 2001-04-24 | Endocare, Inc. | Insertion device for stents and methods for use |
US6346118B1 (en) * | 1983-12-09 | 2002-02-12 | Endovascular Technologies, Inc. | Thoracic graft and delivery catheter |
US6350277B1 (en) * | 1999-01-15 | 2002-02-26 | Scimed Life Systems, Inc. | Stents with temporary retaining bands |
US20020032431A1 (en) * | 1994-12-15 | 2002-03-14 | Ferdinand Kiemeneij | Catheter for percutaneous transradial approach |
US20020035393A1 (en) * | 1999-04-07 | 2002-03-21 | Lashinski Robert D. | Endolumenal prosthesis delivery assembly and method of use |
US6368344B1 (en) * | 1999-12-16 | 2002-04-09 | Advanced Cardiovascular Systems, Inc. | Stent deployment system with reinforced inner member |
US6371979B1 (en) * | 1993-01-27 | 2002-04-16 | Intratherapeutics, Inc. | Stent delivery system |
US20020045928A1 (en) * | 2000-05-04 | 2002-04-18 | Percardia, Inc. | Methods and devices for delivering a ventricular stent |
US20020049490A1 (en) * | 2000-04-11 | 2002-04-25 | Pollock David T. | Single-piece endoprosthesis with high expansion ratios |
US6380457B1 (en) * | 1992-12-30 | 2002-04-30 | Boston Scientific Scimed, Inc. | Apparatus for deploying body implantable stents |
US6485510B1 (en) * | 1999-04-15 | 2002-11-26 | Mayo Foundation For Medical Education And Research | Multi-section stent |
US20020188341A1 (en) * | 2001-05-10 | 2002-12-12 | Elliott Christopher J. | Stent with detachable tethers and method of using same |
US20030014103A1 (en) * | 1995-05-19 | 2003-01-16 | Kanji Inoue | Device for handling an appliance to be implanted |
US6514285B1 (en) * | 1993-03-11 | 2003-02-04 | Medinol Ltd. | Stent |
US20030036768A1 (en) * | 2001-08-14 | 2003-02-20 | Hutchins John E. | Method of and apparatus for positioning and maintaining the position of endoscopic instruments |
US20030040771A1 (en) * | 1999-02-01 | 2003-02-27 | Hideki Hyodoh | Methods for creating woven devices |
US20030045923A1 (en) * | 2001-08-31 | 2003-03-06 | Mehran Bashiri | Hybrid balloon expandable/self expanding stent |
US6533805B1 (en) * | 1996-04-01 | 2003-03-18 | General Surgical Innovations, Inc. | Prosthesis and method for deployment within a body lumen |
US6533807B2 (en) * | 1998-02-05 | 2003-03-18 | Medtronic, Inc. | Radially-expandable stent and delivery system |
US20030055377A1 (en) * | 2000-06-02 | 2003-03-20 | Avantec Vascular Corporation | Exchangeable catheter |
US6537295B2 (en) * | 2001-03-06 | 2003-03-25 | Scimed Life Systems, Inc. | Wire and lock mechanism |
US20030065375A1 (en) * | 2001-10-02 | 2003-04-03 | Alan Eskuri | Nested stent apparatus |
US20030069521A1 (en) * | 2001-10-05 | 2003-04-10 | Brian Reynolds | Composite guidewire |
US6607539B1 (en) * | 2001-05-18 | 2003-08-19 | Endovascular Technologies, Inc. | Electric endovascular implant depolyment system |
US6676666B2 (en) * | 1999-01-11 | 2004-01-13 | Scimed Life Systems, Inc | Medical device delivery system with two sheaths |
US6679910B1 (en) * | 1999-11-12 | 2004-01-20 | Latin American Devices Llc | Intraluminal stent |
US20040024441A1 (en) * | 2002-08-05 | 2004-02-05 | William Bertolino | Medical devices |
US6689120B1 (en) * | 1999-08-06 | 2004-02-10 | Boston Scientific Scimed, Inc. | Reduced profile delivery system |
US6699274B2 (en) * | 2001-01-22 | 2004-03-02 | Scimed Life Systems, Inc. | Stent delivery system and method of manufacturing same |
US6702846B2 (en) * | 1996-04-09 | 2004-03-09 | Endocare, Inc. | Urological stent therapy system and method |
US6702843B1 (en) * | 2000-04-12 | 2004-03-09 | Scimed Life Systems, Inc. | Stent delivery means with balloon retraction means |
US20040049547A1 (en) * | 2001-12-21 | 2004-03-11 | Matthews W. Donald | Methods for providing information over networks responsive to digital device user requests |
US6709425B2 (en) * | 1998-09-30 | 2004-03-23 | C. R. Bard, Inc. | Vascular inducing implants |
US6843802B1 (en) * | 2000-11-16 | 2005-01-18 | Cordis Corporation | Delivery apparatus for a self expanding retractable stent |
US6858034B1 (en) * | 1999-05-20 | 2005-02-22 | Scimed Life Systems, Inc. | Stent delivery system for prevention of kinking, and method of loading and using same |
US6860899B1 (en) * | 1999-04-15 | 2005-03-01 | Boston Scientific Scimed, Inc. | Method for treating neurovascular aneurysms |
US20050049668A1 (en) * | 2003-08-29 | 2005-03-03 | Jones Donald K. | Self-expanding stent and stent delivery system for treatment of vascular stenosis |
US20050049672A1 (en) * | 2003-03-24 | 2005-03-03 | Murphy Kieran P. | Stent delivery system and method using a balloon for a self-expandable stent |
US20050049670A1 (en) * | 2003-08-29 | 2005-03-03 | Jones Donald K. | Self-expanding stent and stent delivery system for treatment of vascular disease |
US20050049669A1 (en) * | 2003-08-29 | 2005-03-03 | Jones Donald K. | Self-expanding stent and stent delivery system with distal protection |
US6875212B2 (en) * | 2000-06-23 | 2005-04-05 | Vertelink Corporation | Curable media for implantable medical device |
US20050080430A1 (en) * | 2003-08-19 | 2005-04-14 | Nmt Medical, Inc. | Expandable sheath tubing |
US6989024B2 (en) * | 2002-02-28 | 2006-01-24 | Counter Clockwise, Inc. | Guidewire loaded stent for delivery through a catheter |
US7011673B2 (en) * | 1999-11-22 | 2006-03-14 | Fischell Robert E | Stent delivery system with a fixed guide wire |
US20060085057A1 (en) * | 2004-10-14 | 2006-04-20 | Cardiomind | Delivery guide member based stent anti-jumping technologies |
US20070027522A1 (en) * | 2005-06-14 | 2007-02-01 | Chang Jean C | Stent delivery and guidewire systems |
US7172620B2 (en) * | 1998-04-02 | 2007-02-06 | Salviac Limited | Delivery catheter |
US20070043419A1 (en) * | 2003-03-26 | 2007-02-22 | Cardiomind, Inc. | Implant delivery technologies |
US20070073379A1 (en) * | 2005-09-29 | 2007-03-29 | Chang Jean C | Stent delivery system |
US20080015541A1 (en) * | 1998-05-01 | 2008-01-17 | Rosenbluth Robert F | Embolectomy Catheters And Methods For Treating Stroke And Other Small Vessel Thromboembolic Disorders |
US20080071309A1 (en) * | 1994-07-08 | 2008-03-20 | Rudy Mazzocchi | Method and device for filtering body fluid |
Family Cites Families (229)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US843802A (en) * | 1906-03-31 | 1907-02-12 | William B Fenn | Closing device for vessels. |
CA1204643A (en) | 1981-09-16 | 1986-05-20 | Hans I. Wallsten | Device for application in blood vessels or other difficulty accessible locations and its use |
SE445884B (en) | 1982-04-30 | 1986-07-28 | Medinvent Sa | DEVICE FOR IMPLANTATION OF A RODFORM PROTECTION |
US4512338A (en) | 1983-01-25 | 1985-04-23 | Balko Alexander B | Process for restoring patency to body vessels |
US4503569A (en) | 1983-03-03 | 1985-03-12 | Dotter Charles T | Transluminally placed expandable graft prosthesis |
US5067957A (en) | 1983-10-14 | 1991-11-26 | Raychem Corporation | Method of inserting medical devices incorporating SIM alloy elements |
US5190546A (en) | 1983-10-14 | 1993-03-02 | Raychem Corporation | Medical devices incorporating SIM alloy elements |
US4562596A (en) | 1984-04-25 | 1986-01-07 | Elliot Kornberg | Aortic graft, device and method for performing an intraluminal abdominal aortic aneurysm repair |
US4580568A (en) * | 1984-10-01 | 1986-04-08 | Cook, Incorporated | Percutaneous endovascular stent and method for insertion thereof |
ES8705239A1 (en) * | 1984-12-05 | 1987-05-01 | Medinvent Sa | A device for implantation and a method of implantation in a vessel using such device. |
SE447061B (en) | 1985-06-10 | 1986-10-27 | Medinvent Sa | INFO DEVICE, SPEC FOR IMPLEMENTATION IN A LIVE ORGANISM |
US4665918A (en) | 1986-01-06 | 1987-05-19 | Garza Gilbert A | Prosthesis system and method |
EP0257091B1 (en) | 1986-02-24 | 1993-07-28 | Robert E. Fischell | An intravascular stent and percutaneous insertion system |
US4878906A (en) | 1986-03-25 | 1989-11-07 | Servetus Partnership | Endoprosthesis for repairing a damaged vessel |
SE453258B (en) | 1986-04-21 | 1988-01-25 | Medinvent Sa | ELASTIC, SELF-EXPANDING PROTEST AND PROCEDURE FOR ITS MANUFACTURING |
SE454482B (en) | 1986-09-30 | 1988-05-09 | Medinvent Sa | DEVICE FOR IMPLANTATION |
SE455834B (en) | 1986-10-31 | 1988-08-15 | Medinvent Sa | DEVICE FOR TRANSLUMINAL IMPLANTATION OF A PRINCIPLE RODFORMALLY RADIALLY EXPANDABLE PROSTHESIS |
US4762128A (en) | 1986-12-09 | 1988-08-09 | Advanced Surgical Intervention, Inc. | Method and apparatus for treating hypertrophy of the prostate gland |
US4893623A (en) * | 1986-12-09 | 1990-01-16 | Advanced Surgical Intervention, Inc. | Method and apparatus for treating hypertrophy of the prostate gland |
JPH088933B2 (en) | 1987-07-10 | 1996-01-31 | 日本ゼオン株式会社 | Catheter |
US5266073A (en) | 1987-12-08 | 1993-11-30 | Wall W Henry | Angioplasty stent |
US6071273A (en) | 1988-02-29 | 2000-06-06 | Scimed Life Systems, Inc. | Fixed wire dilatation balloon catheter |
US4913141A (en) * | 1988-10-25 | 1990-04-03 | Cordis Corporation | Apparatus and method for placement of a stent within a subject vessel |
US5019085A (en) | 1988-10-25 | 1991-05-28 | Cordis Corporation | Apparatus and method for placement of a stent within a subject vessel |
US4950227A (en) | 1988-11-07 | 1990-08-21 | Boston Scientific Corporation | Stent delivery system |
DE9010130U1 (en) | 1989-07-13 | 1990-09-13 | American Medical Systems, Inc., Minnetonka, Minn., Us | |
US5180367A (en) * | 1989-09-06 | 1993-01-19 | Datascope Corporation | Procedure and balloon catheter system for relieving arterial or veinal restrictions without exchanging balloon catheters |
US5035706A (en) | 1989-10-17 | 1991-07-30 | Cook Incorporated | Percutaneous stent and method for retrieval thereof |
US4999539A (en) * | 1989-12-04 | 1991-03-12 | Planar Systems, Inc. | Electrode configuration for reducing contact density in matrix-addressed display panels |
US5122136A (en) | 1990-03-13 | 1992-06-16 | The Regents Of The University Of California | Endovascular electrolytically detachable guidewire tip for the electroformation of thrombus in arteries, veins, aneurysms, vascular malformations and arteriovenous fistulas |
US5569245A (en) | 1990-03-13 | 1996-10-29 | The Regents Of The University Of California | Detachable endovascular occlusion device activated by alternating electric current |
US5851206A (en) | 1990-03-13 | 1998-12-22 | The Regents Of The University Of California | Method and apparatus for endovascular thermal thrombosis and thermal cancer treatment |
US6425893B1 (en) | 1990-03-13 | 2002-07-30 | The Regents Of The University Of California | Method and apparatus for fast electrolytic detachment of an implant |
US6083220A (en) | 1990-03-13 | 2000-07-04 | The Regents Of The University Of California | Endovascular electrolytically detachable wire and tip for the formation of thrombus in arteries, veins, aneurysms, vascular malformations and arteriovenous fistulas |
US5354295A (en) | 1990-03-13 | 1994-10-11 | Target Therapeutics, Inc. | In an endovascular electrolytically detachable wire and tip for the formation of thrombus in arteries, veins, aneurysms, vascular malformations and arteriovenous fistulas |
US5221261A (en) | 1990-04-12 | 1993-06-22 | Schneider (Usa) Inc. | Radially expandable fixation member |
US5071407A (en) | 1990-04-12 | 1991-12-10 | Schneider (U.S.A.) Inc. | Radially expandable fixation member |
IL94138A (en) | 1990-04-19 | 1997-03-18 | Instent Inc | Device for the treatment of constricted fluid conducting ducts |
US5242399A (en) | 1990-04-25 | 1993-09-07 | Advanced Cardiovascular Systems, Inc. | Method and system for stent delivery |
US5158548A (en) | 1990-04-25 | 1992-10-27 | Advanced Cardiovascular Systems, Inc. | Method and system for stent delivery |
US5108407A (en) | 1990-06-08 | 1992-04-28 | Rush-Presbyterian St. Luke's Medical Center | Method and apparatus for placement of an embolic coil |
US5064435A (en) | 1990-06-28 | 1991-11-12 | Schneider (Usa) Inc. | Self-expanding prosthesis having stable axial length |
ES2118742T3 (en) | 1990-10-19 | 1998-10-01 | Smith & Nephew Inc | SURGICAL DEVICE. |
US5160341A (en) | 1990-11-08 | 1992-11-03 | Advanced Surgical Intervention, Inc. | Resorbable urethral stent and apparatus for its insertion |
US5147370A (en) | 1991-06-12 | 1992-09-15 | Mcnamara Thomas O | Nitinol stent for hollow body conduits |
US5242452A (en) | 1991-10-11 | 1993-09-07 | Kanji Inoue | Device for collapsing an appliance collapsible for insertion into human organs |
US5290305A (en) * | 1991-10-11 | 1994-03-01 | Kanji Inoue | Appliance collapsible for insertion into human organs and capable of resilient restoration |
ATE157525T1 (en) | 1991-10-11 | 1997-09-15 | Angiomed Ag | DEVICE FOR EXPANDING A STENOSIS |
US5316023A (en) | 1992-01-08 | 1994-05-31 | Expandable Grafts Partnership | Method for bilateral intra-aortic bypass |
US5407432A (en) * | 1992-03-30 | 1995-04-18 | Pameda N.V. | Method of positioning a stent |
JPH07505316A (en) | 1992-03-31 | 1995-06-15 | ボストン サイエンティフィック コーポレーション | medical wire |
US5263964A (en) | 1992-05-06 | 1993-11-23 | Coil Partners Ltd. | Coaxial traction detachment apparatus and method |
US5772668A (en) | 1992-06-18 | 1998-06-30 | American Biomed, Inc. | Apparatus for placing an endoprosthesis |
US5306294A (en) | 1992-08-05 | 1994-04-26 | Ultrasonic Sensing And Monitoring Systems, Inc. | Stent construction of rolled configuration |
US5707376A (en) | 1992-08-06 | 1998-01-13 | William Cook Europe A/S | Stent introducer and method of use |
ES2059202T3 (en) | 1992-12-16 | 1994-11-01 | Schneider Europ Ag | DEVICE TO IMPLEMENT A SELF-EXPANDABLE ENDOPROTESIS IN A VESSEL. |
US5360401A (en) | 1993-02-18 | 1994-11-01 | Advanced Cardiovascular Systems, Inc. | Catheter for stent delivery |
US5334210A (en) | 1993-04-09 | 1994-08-02 | Cook Incorporated | Vascular occlusion assembly |
US5800453A (en) | 1993-04-19 | 1998-09-01 | Target Therapeutics, Inc. | Detachable embolic coil assembly using interlocking hooks and slots |
US5772609A (en) | 1993-05-11 | 1998-06-30 | Target Therapeutics, Inc. | Guidewire with variable flexibility due to polymeric coatings |
US5480423A (en) | 1993-05-20 | 1996-01-02 | Boston Scientific Corporation | Prosthesis delivery |
DK0627201T3 (en) | 1993-06-02 | 1999-04-26 | Schneider Europ Gmbh | Device for releasing a self-expanding endoprosthesis |
ES2157977T3 (en) | 1993-07-23 | 2001-09-01 | Cook Inc | FLEXIBLE PROBE THAT HAS A CONFORMED CONFIGURATION FROM A MATERIAL SHEET. |
US5445646A (en) | 1993-10-22 | 1995-08-29 | Scimed Lifesystems, Inc. | Single layer hydraulic sheath stent delivery apparatus and method |
US5989280A (en) | 1993-10-22 | 1999-11-23 | Scimed Lifesystems, Inc | Stent delivery apparatus and method |
US5571135A (en) | 1993-10-22 | 1996-11-05 | Scimed Life Systems Inc. | Stent delivery apparatus and method |
US5423829A (en) | 1993-11-03 | 1995-06-13 | Target Therapeutics, Inc. | Electrolytically severable joint for endovascular embolic devices |
DE69419877T2 (en) | 1993-11-04 | 1999-12-16 | Bard Inc C R | Fixed vascular prosthesis |
US5476505A (en) | 1993-11-18 | 1995-12-19 | Advanced Cardiovascular Systems, Inc. | Coiled stent and delivery system |
JPH0737199U (en) | 1993-12-24 | 1995-07-11 | テルモ株式会社 | Guide wire |
US5591196A (en) | 1994-02-10 | 1997-01-07 | Endovascular Systems, Inc. | Method for deployment of radially expandable stents |
US5443477A (en) | 1994-02-10 | 1995-08-22 | Stentco, Inc. | Apparatus and method for deployment of radially expandable stents by a mechanical linkage |
EP0696902B1 (en) | 1994-03-03 | 2005-05-11 | Boston Scientific Limited | Apparatus for detecting separation of a vasoocclusion device |
US5415664A (en) | 1994-03-30 | 1995-05-16 | Corvita Corporation | Method and apparatus for introducing a stent or a stent-graft |
US5554181A (en) | 1994-05-04 | 1996-09-10 | Regents Of The University Of Minnesota | Stent |
WO1995031945A1 (en) | 1994-05-19 | 1995-11-30 | Scimed Life Systems, Inc. | Improved tissue supporting devices |
US5824041A (en) | 1994-06-08 | 1998-10-20 | Medtronic, Inc. | Apparatus and methods for placement and repositioning of intraluminal prostheses |
US5683451A (en) | 1994-06-08 | 1997-11-04 | Cardiovascular Concepts, Inc. | Apparatus and methods for deployment release of intraluminal prostheses |
DE4420142C2 (en) | 1994-06-09 | 2002-06-20 | Angiomed Ag | Device for expanding a stenosis |
US5522836A (en) | 1994-06-27 | 1996-06-04 | Target Therapeutics, Inc. | Electrolytically severable coil assembly with movable detachment point |
JPH10507090A (en) | 1994-10-20 | 1998-07-14 | インステント インコーポレーテッド | Cystoscope delivery system |
CA2163708C (en) | 1994-12-07 | 2007-08-07 | Robert E. Fischell | Integrated dual-function catheter system for balloon angioplasty and stent delivery |
US5578074A (en) | 1994-12-22 | 1996-11-26 | Target Therapeutics, Inc. | Implant delivery method and assembly |
US5522883A (en) | 1995-02-17 | 1996-06-04 | Meadox Medicals, Inc. | Endoprosthesis stent/graft deployment system |
US6818014B2 (en) | 1995-03-01 | 2004-11-16 | Scimed Life Systems, Inc. | Longitudinally flexible expandable stent |
US6059779A (en) | 1995-04-28 | 2000-05-09 | Target Therapeutics, Inc. | Delivery catheter for electrolytically detachable implant |
US5807398A (en) | 1995-04-28 | 1998-09-15 | Shaknovich; Alexander | Shuttle stent delivery catheter |
US5534007A (en) | 1995-05-18 | 1996-07-09 | Scimed Life Systems, Inc. | Stent deployment catheter with collapsible sheath |
US5639274A (en) | 1995-06-02 | 1997-06-17 | Fischell; Robert E. | Integrated catheter system for balloon angioplasty and stent delivery |
US5788707A (en) | 1995-06-07 | 1998-08-04 | Scimed Life Systems, Inc. | Pull back sleeve system with compression resistant inner shaft |
WO1997001368A1 (en) | 1995-06-26 | 1997-01-16 | Trimedyne, Inc. | Therapeutic appliance releasing device |
US5776141A (en) | 1995-08-28 | 1998-07-07 | Localmed, Inc. | Method and apparatus for intraluminal prosthesis delivery |
US5601600A (en) | 1995-09-08 | 1997-02-11 | Conceptus, Inc. | Endoluminal coil delivery system having a mechanical release mechanism |
US5702418A (en) * | 1995-09-12 | 1997-12-30 | Boston Scientific Corporation | Stent delivery system |
US6428489B1 (en) | 1995-12-07 | 2002-08-06 | Precision Vascular Systems, Inc. | Guidewire system |
EP0950385A3 (en) | 1995-12-14 | 1999-10-27 | Prograft Medical, Inc. | Stent-graft deployment apparatus and method |
DE69735530T2 (en) | 1996-01-04 | 2006-08-17 | Chuter, Timothy A.M. Dr., Atherton | FLAT WIRE STENT |
US6878161B2 (en) | 1996-01-05 | 2005-04-12 | Medtronic Vascular, Inc. | Stent graft loading and deployment device and method |
US5690643A (en) | 1996-02-20 | 1997-11-25 | Leocor, Incorporated | Stent delivery system |
US6629981B2 (en) | 2000-07-06 | 2003-10-07 | Endocare, Inc. | Stent delivery system |
US6413269B1 (en) | 2000-07-06 | 2002-07-02 | Endocare, Inc. | Stent delivery system |
US5830179A (en) | 1996-04-09 | 1998-11-03 | Endocare, Inc. | Urological stent therapy system and method |
US5797952A (en) | 1996-06-21 | 1998-08-25 | Localmed, Inc. | System and method for delivering helical stents |
US6077295A (en) | 1996-07-15 | 2000-06-20 | Advanced Cardiovascular Systems, Inc. | Self-expanding stent delivery system |
US6096034A (en) | 1996-07-26 | 2000-08-01 | Target Therapeutics, Inc. | Aneurysm closure device assembly |
US5980514A (en) | 1996-07-26 | 1999-11-09 | Target Therapeutics, Inc. | Aneurysm closure device assembly |
US5800517A (en) | 1996-08-19 | 1998-09-01 | Scimed Life Systems, Inc. | Stent delivery system with storage sleeve |
US5944726A (en) | 1996-08-23 | 1999-08-31 | Scimed Life Systems, Inc. | Stent delivery system having stent securement means |
US6007543A (en) | 1996-08-23 | 1999-12-28 | Scimed Life Systems, Inc. | Stent delivery system with stent securement means |
US5968069A (en) | 1996-08-23 | 1999-10-19 | Scimed Life Systems, Inc. | Stent delivery system having stent securement apparatus |
US6254628B1 (en) | 1996-12-09 | 2001-07-03 | Micro Therapeutics, Inc. | Intracranial stent |
US5772669A (en) | 1996-09-27 | 1998-06-30 | Scimed Life Systems, Inc. | Stent deployment catheter with retractable sheath |
US5843090A (en) * | 1996-11-05 | 1998-12-01 | Schneider (Usa) Inc. | Stent delivery device |
JP2001504017A (en) | 1996-11-15 | 2001-03-27 | クック インコーポレーティッド. | Separable sleeve, stent deployment device |
US6395017B1 (en) | 1996-11-15 | 2002-05-28 | C. R. Bard, Inc. | Endoprosthesis delivery catheter with sequential stage control |
US5968052A (en) | 1996-11-27 | 1999-10-19 | Scimed Life Systems Inc. | Pull back stent delivery system with pistol grip retraction handle |
US5776142A (en) | 1996-12-19 | 1998-07-07 | Medtronic, Inc. | Controllable stent delivery system and method |
US6071286A (en) | 1997-02-19 | 2000-06-06 | Mawad; Michel E. | Combination angioplasty balloon/stent deployment device |
US6152944A (en) | 1997-03-05 | 2000-11-28 | Scimed Life Systems, Inc. | Catheter with removable balloon protector and stent delivery system with removable stent protector |
US5817101A (en) | 1997-03-13 | 1998-10-06 | Schneider (Usa) Inc | Fluid actuated stent delivery system |
US6425915B1 (en) | 1997-03-18 | 2002-07-30 | Endotex Interventional Systems, Inc. | Helical mesh endoprosthesis and methods of use |
US6048360A (en) | 1997-03-18 | 2000-04-11 | Endotex Interventional Systems, Inc. | Methods of making and using coiled sheet graft for single and bifurcated lumens |
US5824054A (en) | 1997-03-18 | 1998-10-20 | Endotex Interventional Systems, Inc. | Coiled sheet graft stent and methods of making and use |
US5824053A (en) | 1997-03-18 | 1998-10-20 | Endotex Interventional Systems, Inc. | Helical mesh endoprosthesis and methods of use |
US6004328A (en) | 1997-06-19 | 1999-12-21 | Solar; Ronald J. | Radially expandable intraluminal stent and delivery catheter therefore and method of using the same |
US6063070A (en) | 1997-08-05 | 2000-05-16 | Target Therapeutics, Inc. | Detachable aneurysm neck bridge (II) |
DE69834920T2 (en) | 1997-08-05 | 2007-05-24 | Boston Scientific Ltd., St. Michael | REMOVABLE SYSTEM FOR CLOSING AN ANEURYSMAS NECK |
US5984929A (en) | 1997-08-29 | 1999-11-16 | Target Therapeutics, Inc. | Fast detaching electronically isolated implant |
US6156061A (en) | 1997-08-29 | 2000-12-05 | Target Therapeutics, Inc. | Fast-detaching electrically insulated implant |
DE69838256T2 (en) | 1997-09-24 | 2008-05-15 | Med Institute, Inc., West Lafayette | RADIAL EXPANDABLE STENT |
US6206888B1 (en) * | 1997-10-01 | 2001-03-27 | Scimed Life Systems, Inc. | Stent delivery system using shape memory retraction |
US5948017A (en) | 1997-10-12 | 1999-09-07 | Taheri; Syde A. | Modular graft assembly |
US5920975A (en) | 1997-11-03 | 1999-07-13 | Advanced Cardiovascular Systems, Inc. | Stent crimping tool and method of use |
US6156062A (en) | 1997-12-03 | 2000-12-05 | Ave Connaught | Helically wrapped interlocking stent |
US6174327B1 (en) * | 1998-02-27 | 2001-01-16 | Scimed Life Systems, Inc. | Stent deployment apparatus and method |
US6068644A (en) * | 1998-03-10 | 2000-05-30 | Cordis Corporation | Embolic coil hydraulic deployment system having improved catheter |
US5980485A (en) * | 1998-03-13 | 1999-11-09 | Medtronics Ave, Inc. | Pressure-sensitive balloon catheter |
US6425898B1 (en) | 1998-03-13 | 2002-07-30 | Cordis Corporation | Delivery apparatus for a self-expanding stent |
US6558415B2 (en) | 1998-03-27 | 2003-05-06 | Intratherapeutics, Inc. | Stent |
US6102942A (en) | 1998-03-30 | 2000-08-15 | Endovascular Technologies, Inc. | Stent/graft deployment catheter with a stent/graft attachment mechanism |
US6290731B1 (en) | 1998-03-30 | 2001-09-18 | Cordis Corporation | Aortic graft having a precursor gasket for repairing an abdominal aortic aneurysm |
US7500988B1 (en) | 2000-11-16 | 2009-03-10 | Cordis Corporation | Stent for use in a stent graft |
US6139564A (en) | 1998-06-16 | 2000-10-31 | Target Therapeutics Inc. | Minimally occlusive flow disruptor stent for bridging aneurysm necks |
US5935148A (en) | 1998-06-24 | 1999-08-10 | Target Therapeutics, Inc. | Detachable, varying flexibility, aneurysm neck bridge |
US6117140A (en) | 1998-06-26 | 2000-09-12 | Scimed Life Systems, Inc. | Stent delivery device |
US20010047185A1 (en) | 1998-08-22 | 2001-11-29 | Stanley Satz | Radioactivatable composition and implantable medical devices formed therefrom |
US6120522A (en) | 1998-08-27 | 2000-09-19 | Scimed Life Systems, Inc. | Self-expanding stent delivery catheter |
US6139524A (en) | 1998-10-16 | 2000-10-31 | Scimed Life Systems, Inc. | Stent delivery system with perfusion |
US6059813A (en) | 1998-11-06 | 2000-05-09 | Scimed Life Systems, Inc. | Rolling membrane stent delivery system |
US6113608A (en) | 1998-11-20 | 2000-09-05 | Scimed Life Systems, Inc. | Stent delivery device |
US6063101A (en) | 1998-11-20 | 2000-05-16 | Precision Vascular Systems, Inc. | Stent apparatus and method |
ATE382310T1 (en) * | 1999-01-22 | 2008-01-15 | Gore Enterprise Holdings Inc | METHOD FOR COMPRESSING AN ENDOPROSTHESIS |
AU772868C (en) * | 1999-02-01 | 2005-08-11 | Board Of Regents, The University Of Texas System | Woven bifurcated and trifurcated stents and methods for making the same |
US6231597B1 (en) | 1999-02-16 | 2001-05-15 | Mark E. Deem | Apparatus and methods for selectively stenting a portion of a vessel wall |
EP1156758B1 (en) | 1999-02-26 | 2008-10-15 | LeMaitre Vascular, Inc. | Coiled stent |
US6248122B1 (en) | 1999-02-26 | 2001-06-19 | Vascular Architects, Inc. | Catheter with controlled release endoluminal prosthesis |
US6161029A (en) * | 1999-03-08 | 2000-12-12 | Medtronic, Inc. | Apparatus and method for fixing electrodes in a blood vessel |
US6183505B1 (en) * | 1999-03-11 | 2001-02-06 | Medtronic Ave, Inc. | Method of stent retention to a delivery catheter balloon-braided retainers |
US6379365B1 (en) | 1999-03-29 | 2002-04-30 | Alexis Diaz | Stent delivery catheter system having grooved shaft |
JP4299973B2 (en) | 1999-05-20 | 2009-07-22 | ボストン サイエンティフィック リミテッド | Stent delivery system with a shrink stabilizer |
US6241758B1 (en) | 1999-05-28 | 2001-06-05 | Advanced Cardiovascular Systems, Inc. | Self-expanding stent delivery system and method of use |
US6280412B1 (en) | 1999-06-17 | 2001-08-28 | Scimed Life Systems, Inc. | Stent securement by balloon modification |
US6398802B1 (en) | 1999-06-21 | 2002-06-04 | Scimed Life Systems, Inc. | Low profile delivery system for stent and graft deployment |
US6632223B1 (en) | 2000-03-30 | 2003-10-14 | The General Hospital Corporation | Pulmonary vein ablation stent and method |
US6264671B1 (en) | 1999-11-15 | 2001-07-24 | Advanced Cardiovascular Systems, Inc. | Stent delivery catheter and method of use |
US6375660B1 (en) | 1999-11-22 | 2002-04-23 | Cordis Corporation | Stent delivery system with a fixed guide wire |
US6936065B2 (en) * | 1999-11-22 | 2005-08-30 | Cordis Corporation | Stent delivery system having a fixed guidewire |
US6306162B1 (en) * | 1999-12-15 | 2001-10-23 | Advanced Cardiovascular Systems, Inc. | Stent delivery system utilizing novel balloon for obtaining variable post-deployment stent characteristics |
US6280465B1 (en) | 1999-12-30 | 2001-08-28 | Advanced Cardiovascular Systems, Inc. | Apparatus and method for delivering a self-expanding stent on a guide wire |
JP2003521334A (en) | 2000-02-04 | 2003-07-15 | ウィルソン−クック メディカル インコーポレイテッド | Stent introducer device |
US6423090B1 (en) | 2000-02-11 | 2002-07-23 | Advanced Cardiovascular Systems, Inc. | Stent pattern with staged expansion |
US6432129B2 (en) | 2000-02-22 | 2002-08-13 | Scimed Life Systems, Inc. | Stent delivery system |
US6391050B1 (en) | 2000-02-29 | 2002-05-21 | Scimed Life Systems, Inc. | Self-expanding stent delivery system |
US6695875B2 (en) | 2000-03-14 | 2004-02-24 | Cook Incorporated | Endovascular stent graft |
US6264683B1 (en) * | 2000-03-17 | 2001-07-24 | Advanced Cardiovascular Systems, Inc. | Stent delivery catheter with bumpers for improved retention of balloon expandable stents |
US7201770B2 (en) | 2000-03-21 | 2007-04-10 | Cordis Corporation | Everting balloon stent delivery system having tapered leading edge |
US6468301B1 (en) | 2000-03-27 | 2002-10-22 | Aga Medical Corporation | Repositionable and recapturable vascular stent/graft |
US6387118B1 (en) | 2000-04-20 | 2002-05-14 | Scimed Life Systems, Inc. | Non-crimped stent delivery system |
DE10026307A1 (en) | 2000-05-26 | 2001-11-29 | Variomed Ag Balzers | Stent, positioning element and insertion catheter |
US20020077693A1 (en) | 2000-12-19 | 2002-06-20 | Barclay Bruce J. | Covered, coiled drug delivery stent and method |
US6679879B2 (en) * | 2000-08-16 | 2004-01-20 | John H. Shadduck | Electrical discharge catheter system for extracting emboli in endovascular interventions |
US6837897B2 (en) * | 2000-10-06 | 2005-01-04 | Scimed Life Systems, Inc. | Lumen support for welding |
US6602226B1 (en) | 2000-10-12 | 2003-08-05 | Scimed Life Systems, Inc. | Low-profile stent delivery system and apparatus |
EP1326672A4 (en) | 2000-10-18 | 2007-03-07 | Nmt Medical Inc | Over-the-wire interlock attachment/detachment mechanism |
US6663664B1 (en) | 2000-10-26 | 2003-12-16 | Advanced Cardiovascular Systems, Inc. | Self-expanding stent with time variable radial force |
US6562064B1 (en) | 2000-10-27 | 2003-05-13 | Vascular Architects, Inc. | Placement catheter assembly |
US6428566B1 (en) | 2000-10-31 | 2002-08-06 | Advanced Cardiovascular Systems, Inc. | Flexible hoop and link sheath for a stent delivery system |
US6602272B2 (en) | 2000-11-02 | 2003-08-05 | Advanced Cardiovascular Systems, Inc. | Devices configured from heat shaped, strain hardened nickel-titanium |
US6582460B1 (en) | 2000-11-20 | 2003-06-24 | Advanced Cardiovascular Systems, Inc. | System and method for accurately deploying a stent |
US6579308B1 (en) | 2000-11-28 | 2003-06-17 | Scimed Life Systems, Inc. | Stent devices with detachable distal or proximal wires |
US6562022B2 (en) | 2000-12-13 | 2003-05-13 | Advanced Cardiovascular Systems, Inc. | Catheter with enhanced reinforcement |
US6468298B1 (en) | 2000-12-28 | 2002-10-22 | Advanced Cardiovascular Systems, Inc. | Gripping delivery system for self-expanding stents and method of using the same |
US6579300B2 (en) * | 2001-01-18 | 2003-06-17 | Scimed Life Systems, Inc. | Steerable sphincterotome and methods for cannulation, papillotomy and sphincterotomy |
US6736839B2 (en) * | 2001-02-01 | 2004-05-18 | Charles Cummings | Medical device delivery system |
US6623518B2 (en) | 2001-02-26 | 2003-09-23 | Ev3 Peripheral, Inc. | Implant delivery system with interlock |
US7294137B2 (en) | 2001-03-27 | 2007-11-13 | Boston Scientific Scimed | Device for multi-modal treatment of vascular lesions |
US6660031B2 (en) | 2001-04-11 | 2003-12-09 | Scimed Life Systems, Inc. | Multi-length delivery system |
US6911038B2 (en) * | 2001-05-08 | 2005-06-28 | Scimed Life Systems, Inc. | Matched balloon to stent shortening |
US6821291B2 (en) | 2001-06-01 | 2004-11-23 | Ams Research Corporation | Retrievable stent and method of use thereof |
US6645238B2 (en) | 2001-07-09 | 2003-11-11 | Scimed Life Systems, Inc. | Skids stent delivery system |
US6726714B2 (en) * | 2001-08-09 | 2004-04-27 | Scimed Life Systems, Inc. | Stent delivery system |
US7594926B2 (en) | 2001-11-09 | 2009-09-29 | Boston Scientific Scimed, Inc. | Methods, systems and devices for delivering stents |
US20030135266A1 (en) | 2001-12-03 | 2003-07-17 | Xtent, Inc. | Apparatus and methods for delivery of multiple distributed stents |
US7004964B2 (en) * | 2002-02-22 | 2006-02-28 | Scimed Life Systems, Inc. | Apparatus and method for deployment of an endoluminal device |
US6830575B2 (en) | 2002-05-08 | 2004-12-14 | Scimed Life Systems, Inc. | Method and device for providing full protection to a stent |
WO2003101347A1 (en) * | 2002-05-31 | 2003-12-11 | Wilson-Cook Medical Inc. | Stent introducer apparatus |
US7264632B2 (en) | 2002-06-07 | 2007-09-04 | Medtronic Vascular, Inc. | Controlled deployment delivery system |
US6833003B2 (en) | 2002-06-24 | 2004-12-21 | Cordis Neurovascular | Expandable stent and delivery system |
US6814746B2 (en) * | 2002-11-01 | 2004-11-09 | Ev3 Peripheral, Inc. | Implant delivery system with marker interlock |
US6849084B2 (en) | 2002-12-31 | 2005-02-01 | Intek Technology L.L.C. | Stent delivery system |
US7300460B2 (en) | 2002-12-31 | 2007-11-27 | Counter Clockwise, Inc. | Bifurcated guidewire and methods of use |
US20040193246A1 (en) | 2003-03-25 | 2004-09-30 | Microvention, Inc. | Methods and apparatus for treating aneurysms and other vascular defects |
US8016869B2 (en) | 2003-03-26 | 2011-09-13 | Biosensors International Group, Ltd. | Guidewire-less stent delivery methods |
US7771463B2 (en) | 2003-03-26 | 2010-08-10 | Ton Dai T | Twist-down implant delivery technologies |
US20050209672A1 (en) | 2004-03-02 | 2005-09-22 | Cardiomind, Inc. | Sliding restraint stent delivery systems |
US20040260377A1 (en) | 2003-06-17 | 2004-12-23 | Medinol, Ltd. | Shape memory alloy endoprosthesis delivery system |
US20050209670A1 (en) | 2004-03-02 | 2005-09-22 | Cardiomind, Inc. | Stent delivery system with diameter adaptive restraint |
US7651521B2 (en) | 2004-03-02 | 2010-01-26 | Cardiomind, Inc. | Corewire actuated delivery system with fixed distal stent-carrying extension |
US20050209671A1 (en) | 2004-03-02 | 2005-09-22 | Cardiomind, Inc. | Corewire actuated delivery system with fixed distal stent-carrying extension |
US20050220836A1 (en) | 2004-03-31 | 2005-10-06 | Robert Falotico | Drug delivery device |
US7766960B2 (en) | 2004-04-30 | 2010-08-03 | Novostent Corporation | Delivery catheter that controls foreshortening of ribbon-type prostheses and methods of making and use |
US20060136037A1 (en) | 2004-10-14 | 2006-06-22 | Debeer Nicholas C | Small vessel stent designs |
US8348858B2 (en) | 2005-01-05 | 2013-01-08 | Stereotaxis, Inc. | Stent delivery guide wire |
US20060190070A1 (en) | 2005-02-23 | 2006-08-24 | Dieck Martin S | Rail stent and methods of use |
KR20080002984A (en) | 2005-04-20 | 2008-01-04 | 쿡 인코포레이티드 | Medical apparatus for rapid insertion |
US20060271097A1 (en) | 2005-05-31 | 2006-11-30 | Kamal Ramzipoor | Electrolytically detachable implantable devices |
US20060276886A1 (en) | 2005-06-07 | 2006-12-07 | Cardiomind, Inc. | Ten-thousandths scale metal reinforced stent delivery guide sheath or restraint |
US20070100414A1 (en) | 2005-11-02 | 2007-05-03 | Cardiomind, Inc. | Indirect-release electrolytic implant delivery systems |
JP5319546B2 (en) | 2006-12-15 | 2013-10-16 | カーディオマインド, インコーポレイテッド | Stent system |
-
2003
- 2003-12-24 US US10/745,778 patent/US8016869B2/en not_active Expired - Fee Related
- 2003-12-24 US US10/746,455 patent/US20040193179A1/en not_active Abandoned
- 2003-12-24 US US10/746,452 patent/US20040193178A1/en not_active Abandoned
Patent Citations (111)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US625628A (en) * | 1899-05-23 | Combined mop and brush holder | ||
US6346118B1 (en) * | 1983-12-09 | 2002-02-12 | Endovascular Technologies, Inc. | Thoracic graft and delivery catheter |
US4733665C2 (en) * | 1985-11-07 | 2002-01-29 | Expandable Grafts Partnership | Expandable intraluminal graft and method and apparatus for implanting an expandable intraluminal graft |
US4733665B1 (en) * | 1985-11-07 | 1994-01-11 | Expandable Grafts Partnership | Expandable intraluminal graft,and method and apparatus for implanting an expandable intraluminal graft |
US4733665A (en) * | 1985-11-07 | 1988-03-29 | Expandable Grafts Partnership | Expandable intraluminal graft, and method and apparatus for implanting an expandable intraluminal graft |
US5102417A (en) * | 1985-11-07 | 1992-04-07 | Expandable Grafts Partnership | Expandable intraluminal graft, and method and apparatus for implanting an expandable intraluminal graft |
US4998539A (en) * | 1987-12-18 | 1991-03-12 | Delsanti Gerard L | Method of using removable endo-arterial devices to repair detachments in the arterial walls |
US4830003A (en) * | 1988-06-17 | 1989-05-16 | Wolff Rodney G | Compressive stent and delivery system |
US5019090A (en) * | 1988-09-01 | 1991-05-28 | Corvita Corporation | Radially expandable endoprosthesis and the like |
US5092877A (en) * | 1988-09-01 | 1992-03-03 | Corvita Corporation | Radially expandable endoprosthesis |
US4990151A (en) * | 1988-09-28 | 1991-02-05 | Medinvent S.A. | Device for transluminal implantation or extraction |
US4990155A (en) * | 1989-05-19 | 1991-02-05 | Wilkoff Howard M | Surgical stent method and apparatus |
US5089006A (en) * | 1989-11-29 | 1992-02-18 | Stiles Frank B | Biological duct liner and installation catheter |
US5108416A (en) * | 1990-02-13 | 1992-04-28 | C. R. Bard, Inc. | Stent introducer system |
US5123917A (en) * | 1990-04-27 | 1992-06-23 | Lee Peter Y | Expandable intraluminal vascular graft |
US5372600A (en) * | 1991-10-31 | 1994-12-13 | Instent Inc. | Stent delivery systems |
US5192297A (en) * | 1991-12-31 | 1993-03-09 | Medtronic, Inc. | Apparatus and method for placement and implantation of a stent |
US5201757A (en) * | 1992-04-03 | 1993-04-13 | Schneider (Usa) Inc. | Medial region deployment of radially self-expanding stents |
US6019785A (en) * | 1992-05-20 | 2000-02-01 | Boston Scientific Corporation | Device with a prosthesis implantable in the body of a patient |
US5405378A (en) * | 1992-05-20 | 1995-04-11 | Strecker; Ernst P. | Device with a prosthesis implantable in the body of a patient |
US20020007208A1 (en) * | 1992-05-20 | 2002-01-17 | Boston Scientific Corporation | Device with a prosthesis implantable in the body of a patient |
US5507771A (en) * | 1992-06-15 | 1996-04-16 | Cook Incorporated | Stent assembly |
US5382259A (en) * | 1992-10-26 | 1995-01-17 | Target Therapeutics, Inc. | Vasoocclusion coil with attached tubular woven or braided fibrous covering |
US5484444A (en) * | 1992-10-31 | 1996-01-16 | Schneider (Europe) A.G. | Device for the implantation of self-expanding endoprostheses |
US6380457B1 (en) * | 1992-12-30 | 2002-04-30 | Boston Scientific Scimed, Inc. | Apparatus for deploying body implantable stents |
US6371979B1 (en) * | 1993-01-27 | 2002-04-16 | Intratherapeutics, Inc. | Stent delivery system |
US6692521B2 (en) * | 1993-03-11 | 2004-02-17 | Medinol Ltd. | Stent |
US6514285B1 (en) * | 1993-03-11 | 2003-02-04 | Medinol Ltd. | Stent |
US6666881B1 (en) * | 1993-03-11 | 2003-12-23 | Medinol Ltd. | Method of heating a nitinol stent |
US5486195A (en) * | 1993-07-26 | 1996-01-23 | Myers; Gene | Method and apparatus for arteriotomy closure |
US5725551A (en) * | 1993-07-26 | 1998-03-10 | Myers; Gene | Method and apparatus for arteriotomy closure |
US5725549A (en) * | 1994-03-11 | 1998-03-10 | Advanced Cardiovascular Systems, Inc. | Coiled stent with locking ends |
US20080071309A1 (en) * | 1994-07-08 | 2008-03-20 | Rudy Mazzocchi | Method and device for filtering body fluid |
US6015429A (en) * | 1994-09-08 | 2000-01-18 | Gore Enterprise Holdings, Inc. | Procedures for introducing stents and stent-grafts |
US20020040236A1 (en) * | 1994-09-08 | 2002-04-04 | Gore Enterprise Holdings, Inc. | Procedures for introducing stents and stent-grafts |
US20020032431A1 (en) * | 1994-12-15 | 2002-03-14 | Ferdinand Kiemeneij | Catheter for percutaneous transradial approach |
US20030018319A1 (en) * | 1994-12-15 | 2003-01-23 | Schneider (Europe) A.G. | Catheter for percutaneous transradial approach |
US5891128A (en) * | 1994-12-30 | 1999-04-06 | Target Therapeutics, Inc. | Solderless electrolytically severable joint for detachable devices placed within the mammalian body |
US5733267A (en) * | 1995-04-05 | 1998-03-31 | Scimed Life Systems, Inc. | Pull back stent delivery system |
US6027516A (en) * | 1995-05-04 | 2000-02-22 | The United States Of America As Represented By The Department Of Health And Human Services | Highly elastic, adjustable helical coil stent |
US20030014103A1 (en) * | 1995-05-19 | 2003-01-16 | Kanji Inoue | Device for handling an appliance to be implanted |
US6053940A (en) * | 1995-10-20 | 2000-04-25 | Wijay; Bandula | Vascular stent |
US6520986B2 (en) * | 1995-12-14 | 2003-02-18 | Gore Enterprise Holdings, Inc. | Kink resistant stent-graft |
US6042605A (en) * | 1995-12-14 | 2000-03-28 | Gore Enterprose Holdings, Inc. | Kink resistant stent-graft |
US6361637B2 (en) * | 1995-12-14 | 2002-03-26 | Gore Enterprise Holdings, Inc. | Method of making a kink resistant stent-graft |
US20020002397A1 (en) * | 1995-12-14 | 2002-01-03 | Martin Gerald Ray | Kink resistant stent-graft |
US6533805B1 (en) * | 1996-04-01 | 2003-03-18 | General Surgical Innovations, Inc. | Prosthesis and method for deployment within a body lumen |
US6702846B2 (en) * | 1996-04-09 | 2004-03-09 | Endocare, Inc. | Urological stent therapy system and method |
US6517548B2 (en) * | 1996-08-23 | 2003-02-11 | Scimed Life Systems, Inc. | Stent delivery system |
US6068634A (en) * | 1996-08-23 | 2000-05-30 | Scimed Life Systems, Inc. | Stent delivery system |
US6019737A (en) * | 1997-03-31 | 2000-02-01 | Terumo Kabushiki Kaisha | Guide wire |
US6027520A (en) * | 1997-05-08 | 2000-02-22 | Embol-X, Inc. | Percutaneous catheter and guidewire having filter and medical device deployment capabilities |
US6168616B1 (en) * | 1997-06-02 | 2001-01-02 | Global Vascular Concepts | Manually expandable stent |
US5873907A (en) * | 1998-01-27 | 1999-02-23 | Endotex Interventional Systems, Inc. | Electrolytic stent delivery system and methods of use |
US6168618B1 (en) * | 1998-01-27 | 2001-01-02 | Endotex Interventional Systems, Inc. | Electrolytic stent delivery system and methods of use |
US6533807B2 (en) * | 1998-02-05 | 2003-03-18 | Medtronic, Inc. | Radially-expandable stent and delivery system |
US6042588A (en) * | 1998-03-03 | 2000-03-28 | Scimed Life Systems, Inc | Stent delivery system |
US6042589A (en) * | 1998-03-17 | 2000-03-28 | Medicorp, S.A. | Reversible-action endoprosthesis delivery device |
US7172620B2 (en) * | 1998-04-02 | 2007-02-06 | Salviac Limited | Delivery catheter |
US20080015541A1 (en) * | 1998-05-01 | 2008-01-17 | Rosenbluth Robert F | Embolectomy Catheters And Methods For Treating Stroke And Other Small Vessel Thromboembolic Disorders |
US6221081B1 (en) * | 1998-09-14 | 2001-04-24 | Endocare, Inc. | Insertion device for stents and methods for use |
US6517569B2 (en) * | 1998-09-14 | 2003-02-11 | Endocare, Inc. | Insertion device for stents and methods for use |
US6203550B1 (en) * | 1998-09-30 | 2001-03-20 | Medtronic, Inc. | Disposable delivery device for endoluminal prostheses |
US6200305B1 (en) * | 1998-09-30 | 2001-03-13 | Medtronic Ave, Inc. | Catheter having a variable length shaft segment and method of use |
US6709425B2 (en) * | 1998-09-30 | 2004-03-23 | C. R. Bard, Inc. | Vascular inducing implants |
US6019779A (en) * | 1998-10-09 | 2000-02-01 | Intratherapeutics Inc. | Multi-filar coil medical stent |
US6214036B1 (en) * | 1998-11-09 | 2001-04-10 | Cordis Corporation | Stent which is easily recaptured and repositioned within the body |
US6676666B2 (en) * | 1999-01-11 | 2004-01-13 | Scimed Life Systems, Inc | Medical device delivery system with two sheaths |
US7022132B2 (en) * | 1999-01-15 | 2006-04-04 | Boston Scientific Scimed, Inc. | Stents with temporary retaining bands |
US6350277B1 (en) * | 1999-01-15 | 2002-02-26 | Scimed Life Systems, Inc. | Stents with temporary retaining bands |
US20020116050A1 (en) * | 1999-01-15 | 2002-08-22 | Scimed Life Systems, Inc. | Stents with temporary retaining bands |
US20030040771A1 (en) * | 1999-02-01 | 2003-02-27 | Hideki Hyodoh | Methods for creating woven devices |
US20030040772A1 (en) * | 1999-02-01 | 2003-02-27 | Hideki Hyodoh | Delivery devices |
US6221097B1 (en) * | 1999-03-22 | 2001-04-24 | Scimed Life System, Inc. | Lubricated sleeve material for stent delivery |
US20020035393A1 (en) * | 1999-04-07 | 2002-03-21 | Lashinski Robert D. | Endolumenal prosthesis delivery assembly and method of use |
US6860899B1 (en) * | 1999-04-15 | 2005-03-01 | Boston Scientific Scimed, Inc. | Method for treating neurovascular aneurysms |
US6485510B1 (en) * | 1999-04-15 | 2002-11-26 | Mayo Foundation For Medical Education And Research | Multi-section stent |
US6858034B1 (en) * | 1999-05-20 | 2005-02-22 | Scimed Life Systems, Inc. | Stent delivery system for prevention of kinking, and method of loading and using same |
US6168579B1 (en) * | 1999-08-04 | 2001-01-02 | Scimed Life Systems, Inc. | Filter flush system and methods of use |
US6689120B1 (en) * | 1999-08-06 | 2004-02-10 | Boston Scientific Scimed, Inc. | Reduced profile delivery system |
US6183481B1 (en) * | 1999-09-22 | 2001-02-06 | Endomed Inc. | Delivery system for self-expanding stents and grafts |
US6679910B1 (en) * | 1999-11-12 | 2004-01-20 | Latin American Devices Llc | Intraluminal stent |
US7011673B2 (en) * | 1999-11-22 | 2006-03-14 | Fischell Robert E | Stent delivery system with a fixed guide wire |
US6368344B1 (en) * | 1999-12-16 | 2002-04-09 | Advanced Cardiovascular Systems, Inc. | Stent deployment system with reinforced inner member |
US20020049490A1 (en) * | 2000-04-11 | 2002-04-25 | Pollock David T. | Single-piece endoprosthesis with high expansion ratios |
US6702843B1 (en) * | 2000-04-12 | 2004-03-09 | Scimed Life Systems, Inc. | Stent delivery means with balloon retraction means |
US20020045928A1 (en) * | 2000-05-04 | 2002-04-18 | Percardia, Inc. | Methods and devices for delivering a ventricular stent |
US20030055377A1 (en) * | 2000-06-02 | 2003-03-20 | Avantec Vascular Corporation | Exchangeable catheter |
US6875212B2 (en) * | 2000-06-23 | 2005-04-05 | Vertelink Corporation | Curable media for implantable medical device |
US6843802B1 (en) * | 2000-11-16 | 2005-01-18 | Cordis Corporation | Delivery apparatus for a self expanding retractable stent |
US6699274B2 (en) * | 2001-01-22 | 2004-03-02 | Scimed Life Systems, Inc. | Stent delivery system and method of manufacturing same |
US6537295B2 (en) * | 2001-03-06 | 2003-03-25 | Scimed Life Systems, Inc. | Wire and lock mechanism |
US6716238B2 (en) * | 2001-05-10 | 2004-04-06 | Scimed Life Systems, Inc. | Stent with detachable tethers and method of using same |
US20020188341A1 (en) * | 2001-05-10 | 2002-12-12 | Elliott Christopher J. | Stent with detachable tethers and method of using same |
US6607539B1 (en) * | 2001-05-18 | 2003-08-19 | Endovascular Technologies, Inc. | Electric endovascular implant depolyment system |
US20030036768A1 (en) * | 2001-08-14 | 2003-02-20 | Hutchins John E. | Method of and apparatus for positioning and maintaining the position of endoscopic instruments |
US20030045923A1 (en) * | 2001-08-31 | 2003-03-06 | Mehran Bashiri | Hybrid balloon expandable/self expanding stent |
US20030065375A1 (en) * | 2001-10-02 | 2003-04-03 | Alan Eskuri | Nested stent apparatus |
US20030069521A1 (en) * | 2001-10-05 | 2003-04-10 | Brian Reynolds | Composite guidewire |
US20040049547A1 (en) * | 2001-12-21 | 2004-03-11 | Matthews W. Donald | Methods for providing information over networks responsive to digital device user requests |
US6989024B2 (en) * | 2002-02-28 | 2006-01-24 | Counter Clockwise, Inc. | Guidewire loaded stent for delivery through a catheter |
US20040024441A1 (en) * | 2002-08-05 | 2004-02-05 | William Bertolino | Medical devices |
US20050049672A1 (en) * | 2003-03-24 | 2005-03-03 | Murphy Kieran P. | Stent delivery system and method using a balloon for a self-expandable stent |
US20070043419A1 (en) * | 2003-03-26 | 2007-02-22 | Cardiomind, Inc. | Implant delivery technologies |
US20050080430A1 (en) * | 2003-08-19 | 2005-04-14 | Nmt Medical, Inc. | Expandable sheath tubing |
US20050049669A1 (en) * | 2003-08-29 | 2005-03-03 | Jones Donald K. | Self-expanding stent and stent delivery system with distal protection |
US20050049670A1 (en) * | 2003-08-29 | 2005-03-03 | Jones Donald K. | Self-expanding stent and stent delivery system for treatment of vascular disease |
US20050049668A1 (en) * | 2003-08-29 | 2005-03-03 | Jones Donald K. | Self-expanding stent and stent delivery system for treatment of vascular stenosis |
US20060085057A1 (en) * | 2004-10-14 | 2006-04-20 | Cardiomind | Delivery guide member based stent anti-jumping technologies |
US20070027522A1 (en) * | 2005-06-14 | 2007-02-01 | Chang Jean C | Stent delivery and guidewire systems |
US20070073379A1 (en) * | 2005-09-29 | 2007-03-29 | Chang Jean C | Stent delivery system |
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---|---|---|---|---|
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US9114038B2 (en) | 2002-02-28 | 2015-08-25 | Back Bay Medical Inc. | Method of delivering a stent |
US7771463B2 (en) | 2003-03-26 | 2010-08-10 | Ton Dai T | Twist-down implant delivery technologies |
US8016869B2 (en) | 2003-03-26 | 2011-09-13 | Biosensors International Group, Ltd. | Guidewire-less stent delivery methods |
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US8382825B2 (en) | 2004-05-25 | 2013-02-26 | Covidien Lp | Flexible vascular occluding device |
US9801744B2 (en) | 2004-05-25 | 2017-10-31 | Covidien Lp | Methods and apparatus for luminal stenting |
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US9393021B2 (en) | 2004-05-25 | 2016-07-19 | Covidien Lp | Flexible vascular occluding device |
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US8617234B2 (en) | 2004-05-25 | 2013-12-31 | Covidien Lp | Flexible vascular occluding device |
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US7749242B2 (en) * | 2004-06-21 | 2010-07-06 | Boston Scientific Scimed, Inc. | Expanding vaso-occlusive device |
US20100228278A1 (en) * | 2004-06-21 | 2010-09-09 | Boston Scientific Scimed, Inc. | Expanding vaso-occlusive device |
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US8486101B2 (en) | 2004-06-21 | 2013-07-16 | Stryker Corporation | Expanding vaso-occlusive device |
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US20040220585A1 (en) | 2004-11-04 |
US8016869B2 (en) | 2011-09-13 |
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