US20030195617A1 - Expandable intraluminal graft - Google Patents

Expandable intraluminal graft Download PDF

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US20030195617A1
US20030195617A1 US10/449,558 US44955803A US2003195617A1 US 20030195617 A1 US20030195617 A1 US 20030195617A1 US 44955803 A US44955803 A US 44955803A US 2003195617 A1 US2003195617 A1 US 2003195617A1
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graft
tubular
body passageway
tubular members
tubular member
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US10/449,558
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Richard Schatz
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Cordis Corp
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Cordis Corp
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Application filed by Cordis Corp filed Critical Cordis Corp
Priority to US10/449,558 priority Critical patent/US20030195617A1/en
Publication of US20030195617A1 publication Critical patent/US20030195617A1/en
Assigned to CORDIS CORPORATION reassignment CORDIS CORPORATION ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: PALMAZ, JULIO C.
Priority to US11/293,014 priority patent/US20060149353A1/en
Abandoned legal-status Critical Current

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/82Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/86Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure
    • A61F2/90Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure
    • A61F2/91Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02Prostheses implantable into the body
    • A61F2/04Hollow or tubular parts of organs, e.g. bladders, tracheae, bronchi or bile ducts
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02Prostheses implantable into the body
    • A61F2/04Hollow or tubular parts of organs, e.g. bladders, tracheae, bronchi or bile ducts
    • A61F2/06Blood vessels
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/95Instruments specially adapted for placement or removal of stents or stent-grafts
    • A61F2/958Inflatable balloons for placing stents or stent-grafts
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02Prostheses implantable into the body
    • A61F2/04Hollow or tubular parts of organs, e.g. bladders, tracheae, bronchi or bile ducts
    • A61F2/06Blood vessels
    • A61F2/07Stent-grafts
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02Prostheses implantable into the body
    • A61F2/04Hollow or tubular parts of organs, e.g. bladders, tracheae, bronchi or bile ducts
    • A61F2/06Blood vessels
    • A61F2/07Stent-grafts
    • A61F2002/075Stent-grafts the stent being loosely attached to the graft material, e.g. by stitching
    • AHUMAN NECESSITIES
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    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/82Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2002/826Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents more than one stent being applied sequentially
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/82Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2002/828Means for connecting a plurality of stents allowing flexibility of the whole structure
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/82Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/86Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure
    • A61F2/90Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure
    • A61F2/91Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes
    • A61F2/915Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes with bands having a meander structure, adjacent bands being connected to each other
    • A61F2002/91533Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes with bands having a meander structure, adjacent bands being connected to each other characterised by the phase between adjacent bands
    • A61F2002/91541Adjacent bands are arranged out of phase
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/82Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/86Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure
    • A61F2/90Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure
    • A61F2/91Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes
    • A61F2/915Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes with bands having a meander structure, adjacent bands being connected to each other
    • A61F2002/9155Adjacent bands being connected to each other
    • A61F2002/91558Adjacent bands being connected to each other connected peak to peak
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2230/00Geometry of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2230/0002Two-dimensional shapes, e.g. cross-sections
    • A61F2230/0004Rounded shapes, e.g. with rounded corners
    • A61F2230/0013Horseshoe-shaped, e.g. crescent-shaped, C-shaped, U-shaped
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2250/00Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2250/0058Additional features; Implant or prostheses properties not otherwise provided for
    • A61F2250/0067Means for introducing or releasing pharmaceutical products into the body

Definitions

  • the invention relates to an expandable intraluminal graft for use within a body passageway or duct and, more particularly, expandable intraluminal vascular grafts which are particularly useful for repairing blood vessels narrowed or occluded by disease; and a method and apparatus for implanting expandable intraluminal grafts.
  • Intraluminal endovascular grafting has been demonstrated by experimentation to present a possible alternative to conventional vascular surgery.
  • Intraluminal endovascular grafting involves the percutaneous insertion into a blood vessel of a tubular prosthetic graft and its delivery via a catheter to the desired location within the vascular system.
  • Advantages of this method over conventional vascular surgery include obviating the need for: surgically exposing, incising, removing, replacing, or bypassing the defective blood vessel.
  • Structures which have previously been used as intraluminal vascular grafts have included coiled stainless steel springs; helically wound coil springs manufactured from an expandable heat-sensitive material; and expanding stainless steel stents formed of stainless steel wire in a zig-zag pattern.
  • the foregoing structures have one major disadvantage in common. Insofar as these structures must be delivered to the desired location within a given body passageway in a collapsed state, in order to pass through the body passageway, there is no effective control over the final, expanded configuration of each structure. For example, the expansion of a particular coiled spring-type graft is predetermined by the spring constant and modulus of elasticity of the particular material utilized to manufacture the coiled spring structure.
  • the amount of expansion of collapsed stents formed of stainless steel wire in a zig-zag pattern predetermine the amount of expansion of collapsed stents formed of stainless steel wire in a zig-zag pattern.
  • the amount of expansion is likewise predetermined by the heat expansion characteristics of the particular alloy utilized in the manufacture of the intraluminal graft.
  • the balloon dilation procedure is typically conducted in the catheterization lab of a hospital, because of the foregoing problem, it is always necessary to have a surgeon on call should the intimal flap block the blood vessel or body passageway. Further, because of the possibility of the intimal flap tearing away from the blood vessel and blocking the lumen, balloon dilations cannot be performed upon certain critical body passageways, such as the left main coronary artery, which leads into the heart. If an intimal flap formed by a balloon dilation procedure abruptly comes down and closes off a critical body passageway, such as the left main coronary artery, the patient could die before any surgical procedures could be performed.
  • Vascular stenoses caused by neointimal fibrosis have proved to be difficult to dilate, requiring high dilating pressures and larger balloon diameters. Similar difficulties have been observed in angioplasties of graft-artery anastomotic strictures and postendarterectomy recurrent stenoses. Percutaneous angioplasty of Takayasu arteritis and neurofibromatosis arterial stenoses may show poor initial response and recurrence which is believed due to the fibrotic nature of these lesions.
  • the length of the body passageway which requires repair may present problems if the length of the required graft cannot negotiate the curves or bends of the body passageway through which the graft is passed by the catheter.
  • it is necessary to support a length of tissue within a body passageway by a graft wherein the length of the required graft exceeds the length of a graft which can be readily delivered via a catheter to the desired location within the vascular system.
  • Some grafts do not have the requisite ability to bend so as to negotiate the curves and bends present within the vascular system, particularly prostheses or grafts which are relatively rigid and resist bending with respect to their longitudinal axes.
  • an expandable intraluminal vascular graft which: prevents recurrence of stenoses in the body passageway; is believed to be able to be utilized in critical body passageways, such as the left main coronary artery of the heart; prevents recoil of the body passageway; can be expanded to a variable size within the body passageway to prevent migration of the graft away from the desired location and to prevent rupturing and/or erosion of the body passageway by the expanded graft; permits tissue of an elongated section of a body passageway to be supported by an elongated graft; and provides the necessary flexibility to negotiate the bends and curves in the vascular system.
  • the present invention includes a plurality of thin-walled tubular members, each having first and second ends and a wall surface disposed between the first and second ends, the wall surface having a substantially uniform thickness and a plurality of slots formed therein, the slots being disposed substantially parallel to the longitudinal axis of each tubular member; a single connector member being disposed between adjacent tubular members to flexibly connect adjacent tubular members, the single connector member being disposed in a substantially parallel relationship with respect to the longitudinal axis of the tubular members and coplanar with each tubular member; each tubular member having a first diameter which permits intraluminal delivery of the tubular members into a body passageway having a lumen; and the tubular members having a second, expanded and deformed diameter, upon the application from the interior of the tubular members of a radially, outwardly extending force, which second diameter is variable and dependent upon the amount of force applied to
  • a further feature of the present invention is that the single connector member may be a thin-walled, elongate bar member, coplanar with adjacent tubular members.
  • An additional feature of the present invention is that a first connector member may be disposed between the second end of a first tubular member and the first end of a second tubular member; a second connector member may be disposed between the second end of the second tubular member and the first end of a third tubular member; the first and second connector members being angularly offset from one another with respect to the longitudinal axis of the tubular members.
  • the expandable intraluminal vascular graft of the present invention when compared with previously proposed prior art intraluminal grafts, has the advantages of: preventing recurrence of stenoses; is believed to permit implantation of grafts in critical body passageways, such as in the left main coronary artery of the heart; prevents recoil of the body passageway; prevents erosion of the body passageway by the expanded graft; permits expansion of the graft to a variable size dependent upon conditions within the body passageway; permits tissue of an elongated section of a body passageway to be supported by an elongated graft; and provides the necessary flexibility to negotiate the bends and curves in tortuous body passageways, such as the vascular system.
  • FIG. 1A is a perspective view of an expandable intraluminal vascular graft, or prosthesis for a body passageway, having a first diameter which permits delivery of the graft, or prosthesis, into a body passageway;
  • FIG. 1B is a perspective view of the graft, or prosthesis, of FIG. 1A, in its expanded configuration when disposed within a body passageway;
  • FIG. 2 is a cross-sectional view of the prosthesis taken along line 2 - 2 of FIG. 1B;
  • FIG. 3 is a cross-sectional view of an apparatus for intraluminally reinforcing a body passageway, or for expanding the lumen of a body passageway, illustrating a prosthesis, or intraluminal vascular graft, in the configuration shown in FIG. 1A;
  • FIG. 4 is a cross-sectional view of the apparatus for intraluminally reinforcing a body passageway, or for expanding the lumen of a body passageway, with the graft, or prosthesis, in the configurations shown in FIG. 1B;
  • FIG. 7 is a perspective view of another embodiment of a graft or prosthesis in accordance with the present invention.
  • FIG. 8 is a perspective view of the graft of FIG. 7, wherein the graft has been bent or articulated.
  • FIGS. 1A and 1B an expandable intraluminal vascular graft, or expandable prosthesis for a body passageway, 70 is illustrated.
  • the terms “expandable intraluminal vascular graft” and “expandable prosthesis” are interchangeably used to some extent in describing the present invention, insofar as the methods, apparatus, and structures of the present invention may be utilized not only in connection with an expandable intraluminal vascular graft for expanding partially occluded segments of a blood vessel, or body passageway, but may also be utilized for many other purposes as an expandable prosthesis for many other types of body passageways.
  • expandable prostheses 70 may also be used for such purposes as: (1) supportive graft placement within blocked arteries opened by transluminal recanalization, but which are likely to collapse in the absence of an internal support; (2) similar use following catheter passage through mediastinal and other veins occluded by inoperable cancers; (3) reinforcement of catheter created intrahepatic communications between portal and hepatic veins in patients suffering from portal hypertension; (4) supportive graft placement of narrowing of the esophagus, the intestine, the ureters, the urethra; and (5) supportive graft reinforcement of reopened and previously obstructed bile ducts.
  • body passageway encompasses any duct within the human body, such as those previously described, as well as any vein, artery, or blood vessel within the human vascular system.
  • the expandable intraluminal vascular graft, or prosthesis, 70 is shown to generally comprise a tubular member 71 having first and second ends 72 , 73 and a wall surface 74 disposed between the first and second ends 72 , 73 .
  • Tubular member 71 has a first diameter, d, which, to be hereinafter described in greater detail, permits intraluminal delivery of the tubular member 71 into a body passageway 80 having a lumen 81 (FIG. 3).
  • tubular member 71 upon the application from the interior of the tubular member 71 of a radially, outwardly extending force, to be hereinafter described in greater detail tubular member 71 has a second, expanded diameter, d′, which second diameter d′ is variable in size and dependent upon the amount of force applied to deform the tubular member 71 .
  • Tubular member 71 may be any suitable material which is compatible with the human body and the bodily fluids (not shown) with which the vascular graft, or prosthesis, 70 may come into contact.
  • Tubular member 71 must also be made of a material which has the requisite strength and elasticity characteristics to permit the tubular member 71 to be expanded and deformed from the configuration shown in FIG. 1A to the configuration shown illustrated in FIG. 1B and further to permit the tubular member 71 to retain its expanded and deformed configuration with the enlarged diameter d′ shown in FIG. 1B and resist radial collapse.
  • Suitable materials for the fabrication of tubular member 71 would include silver, tantalum, stainless steel, gold, titanium or any suitable plastic material having the requisite characteristics previously described.
  • tubular member 71 is initially a thin-walled stainless steel tube having a uniform wall thickness, and a plurality of slots 82 are formed in the wall surface 74 of tubular member 71 .
  • the slots 82 are disposed substantially parallel to the longitudinal axis of the tubular member 71 .
  • the slots 82 are preferably uniformly and circumferentially spaced from adjacent slots 82 , as by connecting members 77 , which connecting members 77 preferably have a length equal to the width of slots 82 , as seen in FIG. 1A.
  • Slots 82 are further uniformly spaced from adjacent slots 82 along the longitudinal axis of the tubular member 71 , which spacing is preferably equal to the width of connecting members 77 .
  • the formation of slots 82 results in at least one elongate member 75 being formed between adjacent slots 82 , elongate member 75 extending between the first and second Ends, 72 , 73 of tubular member 71 , as seen in FIG. 1A.
  • each slot will leave first and second ends with a connecting member 77 disposed at the first and second ends of slots 82 .
  • the first and second ends of each slot 82 are disposed intermediate the first and second ends of adjacent slots 82 along the longitudinal axis of the tubular member 71 .
  • connecting members 77 which are disposed at the first and second ends of each slot 82 , and between elongate members 75 , will in turn be disposed intermediate the first and second ends of adjacent slots 82 along the longitudinal axis of the tubular member 71 .
  • slots 82 are preferably uniformly and circumferentially spaced from adjacent slots, and slots 82 adjacent to one another along the longitudinal axis of tubular member 71 are in a staggered relationship with one another. Alternating slots disposed about the circumference of tubular member 71 at both the first and second ends 72 , 73 of tubular member 71 will only have a length equal to approximately one-half of the length of a complete slot 82 , such half-slot 82 being bounded by members 78 , 79 , at both the first and second ends 72 , 73 of tubular member 71 .
  • the graft, or prosthesis, 70 of FIGS. 1A and 1B is illustrated to have a length approximately equal to the length of two slots 82 , it should be apparent that the length of the graft 70 could be made longer or shorter as desired.
  • graft, or prosthesis, 70 permits graft, or prosthesis, 70 to be expanded uniformly, and outwardly, in a controlled manner into the configuration shown in FIG. 1B, upon the application of a suitable force from the interior of tubular member 71 , as will be hereinafter described in greater detail.
  • the expansion of tubular member 71 into the configuration shown in FIG. 1B is further uniform along the length of tubular member 71 , not only because of the uniform spacing between slots 82 , as previously described, but also because the thickness of the wall surface 74 , or the thickness of connecting members 77 , elongate members 75 , and members 78 , 79 , is the same uniform thickness. As illustrated in FIG.
  • the uniform thickness of elongate member 75 is shown, and the preferred cross-sectional configuration of elongate member 75 , connecting member 77 , and members 78 , 79 , is illustrated, which configuration is rectangular.
  • the cross-sectional configuration of the foregoing components of graft, or prosthesis, 70 could also be square, rectangular, or other cross-sectional configurations.
  • the outer surface 74 of graft, or prothesis, 70 which would be in contact with the body passageway 80 FIG. 4, should be relatively smooth.
  • tubular member 71 is expanded from the configuration shown in FIG. 1A to achieve the configuration shown in FIG. 1B, but tubular member 71 is further “deformed” to achieve that configuration.
  • deformed is meant that the material from which graft, or prosthesis, 70 is manufactured is subjected to a force which is greater than the elastic limit of the material utilized to make tubular member 71 . Accordingly, the force is sufficient to permanently bend elongate members 75 whereby segments of the elongate members 75 pivot about connecting members 77 and move in a circumferential direction as they pivot, whereby the diameter of the tubular member 71 increases from the first diameter, d, to the expanded diameter, d′, of FIG. 1B.
  • tubular member 71 when tubular member 71 has the first diameter, d, shown in FIG. 1A, or after tubular member 71 has been expanded and deformed into the second, expanded diameter, d′, of FIG. 1B, tubular member 71 does not exert any outward, radial force, in that tubular member 71 is not a “spring-like” or “self-expanding member”, which would tend to exert an outwardly radial force.
  • FIGS. 3 and 4 apparatus of the present invention will be described in greater detail.
  • the apparatus of the present invention is useful not only for expanding the lumen of a body passageway, such as an artery, vein, or blood vessel of the human vascular system, but are also useful to perform the previously described procedures to intraluminally reinforce other body passageways or ducts, as previously described.
  • an expandable intraluminal vascular graft, or prosthesis, 70 is disposed or mounted upon a catheter 83 .
  • Catheter 83 has an expandable, inflatable portion 84 associated therewith.
  • Catheter 83 may include means for mounting and retaining 85 the expandable intraluminal vascular graft, of prosthesis, 70 on the expandable, inflatable portion 84 of catheter 83 .
  • the mounting and retaining means 85 could comprise retainer ring members 86 disposed on the catheter 83 adjacent the expandable inflatable portion 84 of catheter 83 ; and a retainer ring member 86 is disposed adjacent each end 72 , 73 of the expandable intraluminal vascular graft, or prosthesis, 70 . As seen in FIG.
  • retainer ring members could be formed integral with catheter 83 , and the retainer ring member 86 adjacent the leading tip 87 of catheter 83 slopes upwardly and away from catheter tip 87 in order to protect and retain graft or prosthesis, 70 as it is inserted into the lumen 81 of body passageway 80 , as to be hereinafter described in greater detail.
  • expandable intraluminal graft, or prosthesis, 70 has been disposed upon catheter 83 , in the manner previously described, the graft, or prosthesis, 70 and catheter 83 are inserted within a body passageway 80 by catheterization of the body passageway 80 in a conventional manner.
  • the catheter 83 and graft, or prosthesis, 70 are delivered to the desired location within the body passageway 80 , whereat it is desired to expand the lumen 81 of body passageway 80 via intraluminal graft 70 , or where it is desired to implant prosthesis 70 .
  • Fluoroscopy, and/or other conventional techniques may be utilized to insure that the catheter 83 and graft, or prosthesis, 70 are delivered to the desired location within the body passageway.
  • Prosthesis, or graft, 70 is then controllably expanded and deformed by controllably expanding the expandable, inflatable portion 84 of catheter 83 , whereby the prosthesis, or graft, 70 is expanded and deformed radially, outwardly into contact with the body passageway 80 , as shown in FIG. 4.
  • the expandable, inflatable portion of catheter 83 may be a conventional angioplasty balloon 88 .
  • angioplasty balloon 88 may be collapsed, or deflated, and the catheter 83 may be removed in a conventional manner from body passageway 80 . If desired, as seen in FIG.
  • catheter 83 having graft or prosthesis, 70 disposed thereon, may be initially encased in a conventional Teflon sheath 89 , or a sheath 89 made of another suitable material, which is pulled away from prosthesis, or graft, 70 , prior to expansion of the prosthesis, or graft, 70 .
  • tubular member 71 of prosthesis, or graft, 70 initially has the first predetermined, collapsed diameter, d, as described in connection with FIG. 1A, in order to permit the insertion of the tubular member, 71 into the body passageway 80 as previously described.
  • the prosthesis 70 is, controllably expanded and deformed to the second diameter, d′, and the second, expanded diameter, d′, is variable and determined by the internal diameter of the body passageway 80 , as shown in FIG. 4, and by the amount of expansion of the inflatable portion 84 of catheter 83 .
  • the expanded and deformed prosthesis 70 upon deflation of angioplasty balloon 88 will not be able to migrate from the desired location within the body passageway 80 , nor will the expansion of the prosthesis 70 be likely to cause a rupture of the body passageway 80 .
  • the prosthesis is not a “spring-like” or “self-expanding member”, the prosthesis is not consistently applying an outward, radial force against the interior surface of body passageway 80 , in excess of that required to resist radial collapse of the body passageway 80 .
  • erosion of the interior surface, or intima, of the artery or body passageway is prevented.
  • expandable intraluminal graft 70 When it is desired to use expandable intraluminal graft 70 to expand the lumen 81 of a body passageway 80 having an area of stenosis, the expansion of intra-luminal vascular graft 70 by angioplasty balloon 88 , allows controlled dilation of the stenotic area and, at the same time controlled expansion and deformation of the vascular graft 70 , whereby vascular graft 70 prevents the body passageway 80 from collapsing and decreasing the size of the previously expanded lumen 81 .
  • the second, expanded diameter d′ of intraluminal vascular graft 70 is variable and determined by the desired expanded internal diameter of body passageway 80 .
  • the expandable intraluminal graft 70 will not migrate away from the desired location within the body passageway 80 upon deflation of angioplasty balloon 88 , nor will the expansion of intraluminal graft 70 likely cause a rupture of body passageway 80 , nor any erosion as previously described. Further, should an intimal flap, or fissure, be formed in body passageway 80 at the location of graft 70 , graft 70 will insure that such an intimal flap will not be able to fold inwardly into body passageway 80 , nor tear loose and flow through body passageway 80 .
  • prostheses, or grafts, 70 of the type previously described in connection with FIGS. 1A and 1B are shown, and the tubular members 71 of grafts, or prostheses, 70 have a biologically inert or biologically compatible coating 90 placed upon wall surfaces 74 of tubular shaped members 71 .
  • a biologically inert coating would be porous polyurethane, Teflon, or other conventional biologically inert plastic materials.
  • the coating 90 should be thin and highly elastic so as not to interfere with the desired expansion and deformation of prosthesis, or graft, 70 .
  • Coating 90 may be further provided with a means for anchoring 91 (FIG.
  • Anchoring means 91 may be comprised of a plurality of radially, outwardly extending projections 92 formed on the coating 90 .
  • the radially outwardly extending projections 92 could comprise a plurality of ridges 93 , or other types of radially, outwardly extending projections.
  • it may be desirable to have a plurality of openings 94 formed in coating 90 as shown in FIG. 5, whereby the fluid contained in body passageway 80 can be in direct contact with the dilated, or expanded, body passageway area.
  • biologically compatible coatings 90 would include coatings made of absorbable polymers such as those used to manufacture absorbable sutures.
  • Such absorbable polymers include polyglycoides, polylactides, and copolymers thereof. Such absorbable polymers could also contain various types of drugs, whereby as the coating 90 is absorbed, or dissolves, the drug would be slowly released into the body passageway 80 .
  • FIGS. 7 and 8 an expandable intraluminal vascular graft, or prosthesis, 70 ′ is shown for implantation in curved body passageways 80 , or for use in the elongated sections of body passageway 80 , when a prosthesis or a graft, 70 ′ is required which is longer than the graft, or prosthesis, 70 of FIG. 1A.
  • Identical reference numerals are used throughout FIGS. 7 and 8 for elements which are the same in design, construction, and operation, as those previously described in connection with FIGS. 1 A- 6 , and primed reference numerals are used for elements which are similar in construction, design, and operation, as those previously described in connection with 1 A- 6 .
  • FIG. 7 and 8 are used for elements which are the same in design, construction, and operation, as those previously described in connection with FIGS. 1 A- 6 .
  • graft, or prosthesis, 70 ′ generally includes a plurality of prostheses, or grafts, 70 as described previously in connection with FIGS. 1A, 1D, and 2 .
  • a single connector member 100 Disposed between adjacent tubular members, 71 , or adjacent grafts, or prostheses, 70 , is a single connector member 100 to flexibly connect adjacent tubular members 71 or grafts, or prostheses, 70 .
  • Connector members 100 are preferably formed of the same material as grafts 70 , as previously described, and connector members 100 may be formed integrally between adjacent grafts 70 , or tubular members 71 , as shown in FIG. 7.
  • connector members 100 along the longitudinal axis of graft, or prosthesis, 70 ′, is the same, in that connector members 100 have the same uniform wall thickness of elongate members 75 and thus form a thin-walled, elongate bar member 101 which is coplanar with adjacent tubular members 71 .
  • the thickness of connector members 100 could alternatively be smaller than elongate member 75 ; however, it is preferable that the outer circumferential surface 102 of connector members 100 lies in the same plane formed by the wall surfaces 74 of grafts, or prostheses, 70 , as seen in FIG. 7.
  • graft, or prosthesis, 70 ′ is illustrated as including three grafts, or prostheses, 70 flexibly connected to one another by connector members 100 , as few as two grafts 70 could be connected to form graft, or prosthesis, 70 ′. Furthermore, many grafts 70 could be flexibly connected by connector members 100 as are desired to form graft, or prosthesis, 70 ′. Preferably, the length of each graft, or prosthesis, 70 is approximately the length of two slots 82 ; however, the length of each graft 70 could be approximately equal to the length of two or more slots 82 .
  • a first connector member 100 is disposed between the second end 73 of a first tubular member 70 A and the first end 72 of a second tubular member 70 B.
  • a second connector member 100 is then disposed between the second end 73 of the second tubular member 70 B and the first end 72 of a third tubular member 70 C.
  • the first and second connector members 100 may be angularly offset from one another with respect to the longitudinal axis of the tubular members 70 to permit the requisite flexibility between the interconnected grafts, or prostheses, 70 .
  • the delivery and expansion of graft, or prosthesis, 70 ′ is the same as that previously described in connection with FIGS. 1A, 1B, and 3 - 4 .
  • the length of the expandable, inflatable portion 84 of catheter 83 would be sized to conform with the length of the graft, or prosthesis, 70 ′, as should be readily apparent to one of ordinary skill in the art. Except for the length of the expandable, inflatable portion 84 , catheter 83 , the method of delivery of graft, or prosthesis, 70 ′ and its subsequent, controllable expansion and deformation are the same as previously described. As seen in FIG.
  • the prosthesis 70 ′ is illustrated in the configuration it would assume when being delivered to the desired location within the body passageway 80 , and the graft, or prosthesis, 70 ′ is disposed upon catheter 83 and is passing through a curved portion of body passageway 80 , such as an arterial bend. Because of the disposition of flexible connector members 100 between adjacent tubular members 71 , or grafts, or prostheses, 70 , graft, or prosthesis, 70 ′ is able to flexibly bend, or articulate, with respect to the longitudinal axis of graft, or prosthesis, 70 ′, so as to be able to negotiate the curves or bends found in body passageways 80 .
  • connector members 100 permit the bending, or articulation of adjacent tubular members in any direction about the longitudinal axis of graft, or prosthesis, 70 ′.
  • tubular members 71 of graft, or prosthesis, 70 ′ will assume the configuration shown in FIG. 1B.

Abstract

A plurality of expandable and deformable intraluminal vascular grafts are expanded within a blood vessel by an angioplasty balloon associated with a catheter to dilate and expand the lumen of a blood vessel. The grafts may be thin-walled tubular members having a plurality of slots disposed substantially parallel to the longitudinal axis of the tubular members, and adjacent grafts are flexibly connected by a single connector member disposed substantially parallel to the longitudinal axis of the tubular members.

Description

    FIELD OF THE INVENTION
  • The invention relates to an expandable intraluminal graft for use within a body passageway or duct and, more particularly, expandable intraluminal vascular grafts which are particularly useful for repairing blood vessels narrowed or occluded by disease; and a method and apparatus for implanting expandable intraluminal grafts. [0001]
  • DESCRIPTION OF THE PRIOR ART
  • Intraluminal endovascular grafting has been demonstrated by experimentation to present a possible alternative to conventional vascular surgery. Intraluminal endovascular grafting involves the percutaneous insertion into a blood vessel of a tubular prosthetic graft and its delivery via a catheter to the desired location within the vascular system. Advantages of this method over conventional vascular surgery include obviating the need for: surgically exposing, incising, removing, replacing, or bypassing the defective blood vessel. [0002]
  • Structures which have previously been used as intraluminal vascular grafts have included coiled stainless steel springs; helically wound coil springs manufactured from an expandable heat-sensitive material; and expanding stainless steel stents formed of stainless steel wire in a zig-zag pattern. In general, the foregoing structures have one major disadvantage in common. Insofar as these structures must be delivered to the desired location within a given body passageway in a collapsed state, in order to pass through the body passageway, there is no effective control over the final, expanded configuration of each structure. For example, the expansion of a particular coiled spring-type graft is predetermined by the spring constant and modulus of elasticity of the particular material utilized to manufacture the coiled spring structure. These same factors predetermine the amount of expansion of collapsed stents formed of stainless steel wire in a zig-zag pattern. In the case of intraluminal grafts, or prostheses, formed of a heat sensitive material which expands upon heating, the amount of expansion is likewise predetermined by the heat expansion characteristics of the particular alloy utilized in the manufacture of the intraluminal graft. [0003]
  • Thus, once the foregoing types of intraluminal grafts are expanded at the desired location within a body passageway, such as within an artery or vein, the expanded size of the graft cannot be changed. If the diameter of the desired body passageway has been miscalculated, an undersized graft might not expand enough to contact the interior surface of the body passageway, so as to be secured thereto. It may then migrate away from the desired location within the body passageway. Likewise, an oversized graft might expand to such an extent that the spring force, or expansion force, exerted by the graft upon the body passageway could cause rupturing of the body passageway. Further, the constant outwardly radiating force exerted upon the interior surface of the body passageway can cause erosion of the internal surface, or intima, of the artery or body passageway. [0004]
  • Another alternative to conventional vascular surgery has been percutaneous balloon dilation of elastic vascular stenoses, or blockages, through use of a catheter mounted angioplasty balloon. In this procedure, the angioplasty balloon is inflated within the stenosed vessel, or body passageway, in order to shear and disrupt the wall components of the vessel to obtain an enlarged lumen. With respect to arterial atheroscleerotic lesions, the relatively incompressible plaque remains unaltered, while the more elastic medial and adventitial layers of the body passageway stretch around the plaque. This process produces dissection, or a splitting and tearing, of the body passageway wall layers, wherein the intima, or internal surface of the artery or body passageway, suffers fissuring. This dissection forms a “flap” of underlying tissue which may reduce the blood flow through the lumen, or block the lumen. Typically, the distending intraluminal pressure within the body passageway can hold the disrupted layer or flap, in place. If the intimal flap created by the balloon dilation procedure is not maintained in place against the expanded intima, the intimal flap can fold down into the lumen and close off the lumen, or may even become detached and enter the body passageway. When the intimal flap closes off the body passageway, immediate surgery is necessary to correct this problem. [0005]
  • Although the balloon dilation procedure is typically conducted in the catheterization lab of a hospital, because of the foregoing problem, it is always necessary to have a surgeon on call should the intimal flap block the blood vessel or body passageway. Further, because of the possibility of the intimal flap tearing away from the blood vessel and blocking the lumen, balloon dilations cannot be performed upon certain critical body passageways, such as the left main coronary artery, which leads into the heart. If an intimal flap formed by a balloon dilation procedure abruptly comes down and closes off a critical body passageway, such as the left main coronary artery, the patient could die before any surgical procedures could be performed. [0006]
  • Additional disadvantages associated with balloon dilation of elastic vascular stenoses is that many fail because of elastic recoil of the stenotic lesion. This usually occurs due to a high fibrocollagenous content in the lesion and is sometimes due to certain mechanical characteristics of the area to be dilated. Thus, although the body passageway may initially be successfully expanded by a balloon dilation procedure, subsequent, early restenosis can occur due to the recoil of the body passageway wall which decreases the size of the previously expanded lumen of the body passageway. For example, stenoses of the renal artery at the ostium are known to be refractory to balloon dilation because the dilating forces are applied to the aortic wall rather than to the renal artery itself. Vascular stenoses caused by neointimal fibrosis, such as those seen in dialysis-access fistulas, have proved to be difficult to dilate, requiring high dilating pressures and larger balloon diameters. Similar difficulties have been observed in angioplasties of graft-artery anastomotic strictures and postendarterectomy recurrent stenoses. Percutaneous angioplasty of Takayasu arteritis and neurofibromatosis arterial stenoses may show poor initial response and recurrence which is believed due to the fibrotic nature of these lesions. [0007]
  • For repairing blood vessels narrowed or occluded by disease, or repairing other body passageways, the length of the body passageway which requires repair, as by the insertion of a tubular prosthetic graft, may present problems if the length of the required graft cannot negotiate the curves or bends of the body passageway through which the graft is passed by the catheter. In other words, in many instances, it is necessary to support a length of tissue within a body passageway by a graft, wherein the length of the required graft exceeds the length of a graft which can be readily delivered via a catheter to the desired location within the vascular system. Some grafts do not have the requisite ability to bend so as to negotiate the curves and bends present within the vascular system, particularly prostheses or grafts which are relatively rigid and resist bending with respect to their longitudinal axes. [0008]
  • Accordingly, prior to the development of the present invention, there has been no expandable intraluminal vascular graft for expanding the lumen of a body passageway, which: prevents recurrence of stenoses in the body passageway; can be utilized for critical body passageways, such as the left main coronary artery of a patient's heart; prevents recoil of the body passageway wall; allows the intraluminal graft to be expanded to a variable size to prevent migration of the graft away from the desired location and prevents rupturing and/or erosion of the body passageway by the expanded graft; permits tissue of an elongated section of a body passageway to be supported by an elongated graft; and provides the necessary flexibility to negotiate the bends and curves in the vascular system. Therefore, the art has sought an expandable intraluminal vascular graft which: prevents recurrence of stenoses in the body passageway; is believed to be able to be utilized in critical body passageways, such as the left main coronary artery of the heart; prevents recoil of the body passageway; can be expanded to a variable size within the body passageway to prevent migration of the graft away from the desired location and to prevent rupturing and/or erosion of the body passageway by the expanded graft; permits tissue of an elongated section of a body passageway to be supported by an elongated graft; and provides the necessary flexibility to negotiate the bends and curves in the vascular system. [0009]
  • SUMMARY OF THE INVENTION
  • In accordance with the invention, the foregoing advantages have been achieved by the present expandable intraluminal vascular graft. The present invention includes a plurality of thin-walled tubular members, each having first and second ends and a wall surface disposed between the first and second ends, the wall surface having a substantially uniform thickness and a plurality of slots formed therein, the slots being disposed substantially parallel to the longitudinal axis of each tubular member; a single connector member being disposed between adjacent tubular members to flexibly connect adjacent tubular members, the single connector member being disposed in a substantially parallel relationship with respect to the longitudinal axis of the tubular members and coplanar with each tubular member; each tubular member having a first diameter which permits intraluminal delivery of the tubular members into a body passageway having a lumen; and the tubular members having a second, expanded and deformed diameter, upon the application from the interior of the tubular members of a radially, outwardly extending force, which second diameter is variable and dependent upon the amount of force applied to the tubular members, whereby the tubular members may be expanded and deformed to expand the lumen of the body passageway. [0010]
  • A further feature of the present invention is that the single connector member may be a thin-walled, elongate bar member, coplanar with adjacent tubular members. An additional feature of the present invention is that a first connector member may be disposed between the second end of a first tubular member and the first end of a second tubular member; a second connector member may be disposed between the second end of the second tubular member and the first end of a third tubular member; the first and second connector members being angularly offset from one another with respect to the longitudinal axis of the tubular members. [0011]
  • The expandable intraluminal vascular graft of the present invention, when compared with previously proposed prior art intraluminal grafts, has the advantages of: preventing recurrence of stenoses; is believed to permit implantation of grafts in critical body passageways, such as in the left main coronary artery of the heart; prevents recoil of the body passageway; prevents erosion of the body passageway by the expanded graft; permits expansion of the graft to a variable size dependent upon conditions within the body passageway; permits tissue of an elongated section of a body passageway to be supported by an elongated graft; and provides the necessary flexibility to negotiate the bends and curves in tortuous body passageways, such as the vascular system. [0012]
  • BRIEF DESCRIPTION OF THE DRAWINGS
  • In the drawings: [0013]
  • FIG. 1A is a perspective view of an expandable intraluminal vascular graft, or prosthesis for a body passageway, having a first diameter which permits delivery of the graft, or prosthesis, into a body passageway; [0014]
  • FIG. 1B is a perspective view of the graft, or prosthesis, of FIG. 1A, in its expanded configuration when disposed within a body passageway; [0015]
  • FIG. 2 is a cross-sectional view of the prosthesis taken along line [0016] 2-2 of FIG. 1B;
  • FIG. 3 is a cross-sectional view of an apparatus for intraluminally reinforcing a body passageway, or for expanding the lumen of a body passageway, illustrating a prosthesis, or intraluminal vascular graft, in the configuration shown in FIG. 1A; [0017]
  • FIG. 4 is a cross-sectional view of the apparatus for intraluminally reinforcing a body passageway, or for expanding the lumen of a body passageway, with the graft, or prosthesis, in the configurations shown in FIG. 1B; [0018]
  • FIGS. 5 and 6 are perspective views of prostheses for a body passageway, with the grafts, or prostheses, having a coating thereon; [0019]
  • FIG. 7 is a perspective view of another embodiment of a graft or prosthesis in accordance with the present invention; and [0020]
  • FIG. 8 is a perspective view of the graft of FIG. 7, wherein the graft has been bent or articulated.[0021]
  • While the invention will be described in connection with the preferred embodiment, it will be understood that it is not intended to limit the invention to that embodiment. On the contrary, it is intended to cover all alternatives, modifications, and equivalents, as may be included within the spirit and scope of the invention as defined by the appended claims. [0022]
  • DETAILED DESCRIPTION OF THE INVENTION
  • In FIGS. 1A and 1B, an expandable intraluminal vascular graft, or expandable prosthesis for a body passageway, [0023] 70 is illustrated. It should be understood that the terms “expandable intraluminal vascular graft” and “expandable prosthesis” are interchangeably used to some extent in describing the present invention, insofar as the methods, apparatus, and structures of the present invention may be utilized not only in connection with an expandable intraluminal vascular graft for expanding partially occluded segments of a blood vessel, or body passageway, but may also be utilized for many other purposes as an expandable prosthesis for many other types of body passageways. For example, expandable prostheses 70 may also be used for such purposes as: (1) supportive graft placement within blocked arteries opened by transluminal recanalization, but which are likely to collapse in the absence of an internal support; (2) similar use following catheter passage through mediastinal and other veins occluded by inoperable cancers; (3) reinforcement of catheter created intrahepatic communications between portal and hepatic veins in patients suffering from portal hypertension; (4) supportive graft placement of narrowing of the esophagus, the intestine, the ureters, the urethra; and (5) supportive graft reinforcement of reopened and previously obstructed bile ducts. Accordingly, use of the term “prosthesis” encompasses the foregoing usages within various types of body passageways, and the use of the term “intraluminal vascular graft” encompasses use for expanding the lumen of a body passageway. Further, in this regard, the term “body passageway” encompasses any duct within the human body, such as those previously described, as well as any vein, artery, or blood vessel within the human vascular system.
  • Still with reference to FIGS. 1A and 1B, the expandable intraluminal vascular graft, or prosthesis, [0024] 70 is shown to generally comprise a tubular member 71 having first and second ends 72, 73 and a wall surface 74 disposed between the first and second ends 72, 73. Tubular member 71 has a first diameter, d, which, to be hereinafter described in greater detail, permits intraluminal delivery of the tubular member 71 into a body passageway 80 having a lumen 81 (FIG. 3). With reference to FIG. 1B, upon the application from the interior of the tubular member 71 of a radially, outwardly extending force, to be hereinafter described in greater detail tubular member 71 has a second, expanded diameter, d′, which second diameter d′ is variable in size and dependent upon the amount of force applied to deform the tubular member 71.
  • [0025] Tubular member 71, may be any suitable material which is compatible with the human body and the bodily fluids (not shown) with which the vascular graft, or prosthesis, 70 may come into contact. Tubular member 71 must also be made of a material which has the requisite strength and elasticity characteristics to permit the tubular member 71 to be expanded and deformed from the configuration shown in FIG. 1A to the configuration shown illustrated in FIG. 1B and further to permit the tubular member 71 to retain its expanded and deformed configuration with the enlarged diameter d′ shown in FIG. 1B and resist radial collapse. Suitable materials for the fabrication of tubular member 71 would include silver, tantalum, stainless steel, gold, titanium or any suitable plastic material having the requisite characteristics previously described.
  • Preferably, [0026] tubular member 71 is initially a thin-walled stainless steel tube having a uniform wall thickness, and a plurality of slots 82 are formed in the wall surface 74 of tubular member 71. As seen in FIG. 1A when tubular member 71 has the first diameter d, the slots 82 are disposed substantially parallel to the longitudinal axis of the tubular member 71. As seen in FIG. 1A, the slots 82 are preferably uniformly and circumferentially spaced from adjacent slots 82, as by connecting members 77, which connecting members 77 preferably have a length equal to the width of slots 82, as seen in FIG. 1A. Slots 82 are further uniformly spaced from adjacent slots 82 along the longitudinal axis of the tubular member 71, which spacing is preferably equal to the width of connecting members 77. Thus, the formation of slots 82 results in at least one elongate member 75 being formed between adjacent slots 82, elongate member 75 extending between the first and second Ends, 72, 73 of tubular member 71, as seen in FIG. 1A.
  • Still with reference to FIG. 1A, each slot will leave first and second ends with a connecting [0027] member 77 disposed at the first and second ends of slots 82. Preferably, the first and second ends of each slot 82 are disposed intermediate the first and second ends of adjacent slots 82 along the longitudinal axis of the tubular member 71. Thus, connecting members 77, which are disposed at the first and second ends of each slot 82, and between elongate members 75, will in turn be disposed intermediate the first and second ends of adjacent slots 82 along the longitudinal axis of the tubular member 71. Accordingly, slots 82 are preferably uniformly and circumferentially spaced from adjacent slots, and slots 82 adjacent to one another along the longitudinal axis of tubular member 71 are in a staggered relationship with one another. Alternating slots disposed about the circumference of tubular member 71 at both the first and second ends 72, 73 of tubular member 71 will only have a length equal to approximately one-half of the length of a complete slot 82, such half-slot 82 being bounded by members 78, 79, at both the first and second ends 72, 73 of tubular member 71. Although the graft, or prosthesis, 70 of FIGS. 1A and 1B is illustrated to have a length approximately equal to the length of two slots 82, it should be apparent that the length of the graft 70 could be made longer or shorter as desired.
  • The foregoing described construction of graft, or prosthesis, [0028] 70 permits graft, or prosthesis, 70 to be expanded uniformly, and outwardly, in a controlled manner into the configuration shown in FIG. 1B, upon the application of a suitable force from the interior of tubular member 71, as will be hereinafter described in greater detail. The expansion of tubular member 71 into the configuration shown in FIG. 1B is further uniform along the length of tubular member 71, not only because of the uniform spacing between slots 82, as previously described, but also because the thickness of the wall surface 74, or the thickness of connecting members 77, elongate members 75, and members 78, 79, is the same uniform thickness. As illustrated in FIG. 2, the uniform thickness of elongate member 75 is shown, and the preferred cross-sectional configuration of elongate member 75, connecting member 77, and members 78, 79, is illustrated, which configuration is rectangular. It should of course be understood by those skilled in the art, that the cross-sectional configuration of the foregoing components of graft, or prosthesis, 70 could also be square, rectangular, or other cross-sectional configurations. As will be hereinafter described in greater detail, it is preferable that the outer surface 74 of graft, or prothesis, 70, which would be in contact with the body passageway 80 FIG. 4, should be relatively smooth.
  • With reference to FIG. 1B, it is seen that after the graft, or [0029] prosthesis 70, has been expanded and deformed into the configuration of FIG. 1B, the slots 82 will assume a substantially hexagonal configuration when the tubular member 71 has the second, expanded diameter, d′, as shown in FIG. 1B. Such a hexagonal configuration will result when the slots 82 initially have a substantially rectangular configuration when the tubular member 71 has the first diameter, d, illustrated in FIG. 1A. It should be noted that were the width of slots 82 to be substantially reduced, whereby the length of connecting member 77 would approximate a single point intersection, the expansion of such a tubular member 71 would result in slots 82 assuming a configuration which would be substantially a parallelogram (not shown).
  • It should be noted that not only is [0030] tubular member 71 expanded from the configuration shown in FIG. 1A to achieve the configuration shown in FIG. 1B, but tubular member 71 is further “deformed” to achieve that configuration. By use of the term “deformed” is meant that the material from which graft, or prosthesis, 70 is manufactured is subjected to a force which is greater than the elastic limit of the material utilized to make tubular member 71. Accordingly, the force is sufficient to permanently bend elongate members 75 whereby segments of the elongate members 75 pivot about connecting members 77 and move in a circumferential direction as they pivot, whereby the diameter of the tubular member 71 increases from the first diameter, d, to the expanded diameter, d′, of FIG. 1B. The force to be applied to expand tubular member 71, which is applied in the manner which will be hereinafter described in greater detail, must thus be sufficient to not only expand tubular member 71, but also to deform elongate member 75, in the manner previously described, whereby the portions of the elongate members 75 which pivot about the ends of connecting members 77 do not “spring back” and assume their configuration shown in FIG. 1A, but rather retain the configuration thereof in FIG. 1B. Once graft, or prosthesis, 70 has been expanded and deformed into the configuration shown in FIG. 1B, graft, or prosthesis 70, will serve to prevent a body passageway from collapsing as will be hereinafter described in greater detail. It should be noted that when tubular member 71 has the first diameter, d, shown in FIG. 1A, or after tubular member 71 has been expanded and deformed into the second, expanded diameter, d′, of FIG. 1B, tubular member 71 does not exert any outward, radial force, in that tubular member 71 is not a “spring-like” or “self-expanding member”, which would tend to exert an outwardly radial force.
  • With reference now to FIGS. 3 and 4, apparatus of the present invention will be described in greater detail. Once again, it should be understood that the apparatus of the present invention is useful not only for expanding the lumen of a body passageway, such as an artery, vein, or blood vessel of the human vascular system, but are also useful to perform the previously described procedures to intraluminally reinforce other body passageways or ducts, as previously described. Still with reference to FIGS. 3 and 4, an expandable intraluminal vascular graft, or prosthesis, [0031] 70, of the type described in connection with FIGS. 1A and 1B, is disposed or mounted upon a catheter 83. Catheter 83 has an expandable, inflatable portion 84 associated therewith. Catheter 83 may include means for mounting and retaining 85 the expandable intraluminal vascular graft, of prosthesis, 70 on the expandable, inflatable portion 84 of catheter 83. The mounting and retaining means 85 could comprise retainer ring members 86 disposed on the catheter 83 adjacent the expandable inflatable portion 84 of catheter 83; and a retainer ring member 86 is disposed adjacent each end 72, 73 of the expandable intraluminal vascular graft, or prosthesis, 70. As seen in FIG. 3, retainer ring members could be formed integral with catheter 83, and the retainer ring member 86 adjacent the leading tip 87 of catheter 83 slopes upwardly and away from catheter tip 87 in order to protect and retain graft or prosthesis, 70 as it is inserted into the lumen 81 of body passageway 80, as to be hereinafter described in greater detail. The remaining retainer ring member 86 as shown in FIG. 3, slopes downwardly away from tip 87 of catheter 83, to insure easy removal of catheter 83 from body passageway 80. After expandable intraluminal graft, or prosthesis, 70 has been disposed upon catheter 83, in the manner previously described, the graft, or prosthesis, 70 and catheter 83 are inserted within a body passageway 80 by catheterization of the body passageway 80 in a conventional manner.
  • In a conventional manner, the [0032] catheter 83 and graft, or prosthesis, 70 are delivered to the desired location within the body passageway 80, whereat it is desired to expand the lumen 81 of body passageway 80 via intraluminal graft 70, or where it is desired to implant prosthesis 70. Fluoroscopy, and/or other conventional techniques may be utilized to insure that the catheter 83 and graft, or prosthesis, 70 are delivered to the desired location within the body passageway. Prosthesis, or graft, 70 is then controllably expanded and deformed by controllably expanding the expandable, inflatable portion 84 of catheter 83, whereby the prosthesis, or graft, 70 is expanded and deformed radially, outwardly into contact with the body passageway 80, as shown in FIG. 4. In this regard, the expandable, inflatable portion of catheter 83 may be a conventional angioplasty balloon 88. After the desired expansion and deformation of prosthesis, or graft, 70 has been accomplished, angioplasty balloon 88 may be collapsed, or deflated, and the catheter 83 may be removed in a conventional manner from body passageway 80. If desired, as seen in FIG. 3, catheter 83, having graft or prosthesis, 70 disposed thereon, may be initially encased in a conventional Teflon sheath 89, or a sheath 89 made of another suitable material, which is pulled away from prosthesis, or graft, 70, prior to expansion of the prosthesis, or graft, 70.
  • Still with reference to FIGS. 3 and 4, it should be noted that [0033] tubular member 71 of prosthesis, or graft, 70 initially has the first predetermined, collapsed diameter, d, as described in connection with FIG. 1A, in order to permit the insertion of the tubular member, 71 into the body passageway 80 as previously described. When it is desired to implant prosthesis 70 within a body passageway 80 for the purposes previously described, the prosthesis 70 is, controllably expanded and deformed to the second diameter, d′, and the second, expanded diameter, d′, is variable and determined by the internal diameter of the body passageway 80, as shown in FIG. 4, and by the amount of expansion of the inflatable portion 84 of catheter 83. Accordingly, the expanded and deformed prosthesis 70, upon deflation of angioplasty balloon 88 will not be able to migrate from the desired location within the body passageway 80, nor will the expansion of the prosthesis 70 be likely to cause a rupture of the body passageway 80. Furthermore, insofar as prosthesis, or graft, 70 is not a “spring-like” or “self-expanding member”, the prosthesis is not consistently applying an outward, radial force against the interior surface of body passageway 80, in excess of that required to resist radial collapse of the body passageway 80. Thus, erosion of the interior surface, or intima, of the artery or body passageway is prevented.
  • When it is desired to use expandable [0034] intraluminal graft 70 to expand the lumen 81 of a body passageway 80 having an area of stenosis, the expansion of intra-luminal vascular graft 70 by angioplasty balloon 88, allows controlled dilation of the stenotic area and, at the same time controlled expansion and deformation of the vascular graft 70, whereby vascular graft 70 prevents the body passageway 80 from collapsing and decreasing the size of the previously expanded lumen 81. Once again, the second, expanded diameter d′ of intraluminal vascular graft 70, as shown in FIG. 4, is variable and determined by the desired expanded internal diameter of body passageway 80. Thus, the expandable intraluminal graft 70 will not migrate away from the desired location within the body passageway 80 upon deflation of angioplasty balloon 88, nor will the expansion of intraluminal graft 70 likely cause a rupture of body passageway 80, nor any erosion as previously described. Further, should an intimal flap, or fissure, be formed in body passageway 80 at the location of graft 70, graft 70 will insure that such an intimal flap will not be able to fold inwardly into body passageway 80, nor tear loose and flow through body passageway 80. In the situation of utilizing graft 70 in the manner previously described to expand the lumen of a portion of a critical body passageway, such as the left main coronary artery, it is believed that the intimal flap will be unable to occlude the left main coronary artery of the heart and cause the death of the patient.
  • Because it is only necessary to inflate angioplasty balloon [0035] 88 one time in order to expand and deform graft 70, it is believed that a greater amount of endothelium, or inner layer of the intima, or inner surface of the body passageway, will be preserved, insofar as the extent of endothelial denudation during transluminal angioplasty is proportional to the balloon inflation time. Further, in theory, the amount of preserved endothelium should be large because in the expanded configuration of graft 70, potentially 80% of the endothelium is exposed through the openings or expanded slots 82 of graft 70. It is further believed that intact patches of endothelium within expanded slots 82 of graft 70 may result in a rapid, multicentric endothelialization pattern as shown by experimental studies.
  • With reference now to FIGS. 5 and 6, prostheses, or grafts, [0036] 70 of the type previously described in connection with FIGS. 1A and 1B are shown, and the tubular members 71 of grafts, or prostheses, 70 have a biologically inert or biologically compatible coating 90 placed upon wall surfaces 74 of tubular shaped members 71. Examples of a suitable biologically inert coating would be porous polyurethane, Teflon, or other conventional biologically inert plastic materials. The coating 90 should be thin and highly elastic so as not to interfere with the desired expansion and deformation of prosthesis, or graft, 70. Coating 90 may be further provided with a means for anchoring 91 (FIG. 6) the tubular member 71 to the body passageway 80. Anchoring means 91 may be comprised of a plurality of radially, outwardly extending projections 92 formed on the coating 90. As seen in FIG. 6, the radially outwardly extending projections 92 could comprise a plurality of ridges 93, or other types of radially, outwardly extending projections. Further, it may be desirable to have a plurality of openings 94 formed in coating 90, as shown in FIG. 5, whereby the fluid contained in body passageway 80 can be in direct contact with the dilated, or expanded, body passageway area. Examples of biologically compatible coatings 90 would include coatings made of absorbable polymers such as those used to manufacture absorbable sutures. Such absorbable polymers include polyglycoides, polylactides, and copolymers thereof. Such absorbable polymers could also contain various types of drugs, whereby as the coating 90 is absorbed, or dissolves, the drug would be slowly released into the body passageway 80.
  • Turning now to FIGS. 7 and 8, an expandable intraluminal vascular graft, or prosthesis, [0037] 70′ is shown for implantation in curved body passageways 80, or for use in the elongated sections of body passageway 80, when a prosthesis or a graft, 70′ is required which is longer than the graft, or prosthesis, 70 of FIG. 1A. Identical reference numerals are used throughout FIGS. 7 and 8 for elements which are the same in design, construction, and operation, as those previously described in connection with FIGS. 1A-6, and primed reference numerals are used for elements which are similar in construction, design, and operation, as those previously described in connection with 1A-6. As seen in FIG. 7, graft, or prosthesis, 70′ generally includes a plurality of prostheses, or grafts, 70 as described previously in connection with FIGS. 1A, 1D, and 2. Disposed between adjacent tubular members, 71, or adjacent grafts, or prostheses, 70, is a single connector member 100 to flexibly connect adjacent tubular members 71 or grafts, or prostheses, 70. Connector members 100 are preferably formed of the same material as grafts 70, as previously described, and connector members 100 may be formed integrally between adjacent grafts 70, or tubular members 71, as shown in FIG. 7. The cross-sectional configuration of connector members 100, along the longitudinal axis of graft, or prosthesis, 70′, is the same, in that connector members 100 have the same uniform wall thickness of elongate members 75 and thus form a thin-walled, elongate bar member 101 which is coplanar with adjacent tubular members 71. Of course, it should be readily apparent to one of ordinary skill in the art, that the thickness of connector members 100 could alternatively be smaller than elongate member 75; however, it is preferable that the outer circumferential surface 102 of connector members 100 lies in the same plane formed by the wall surfaces 74 of grafts, or prostheses, 70, as seen in FIG. 7.
  • Still with reference to FIGS. [0038] 7-8, it should be noted that although graft, or prosthesis, 70′ is illustrated as including three grafts, or prostheses, 70 flexibly connected to one another by connector members 100, as few as two grafts 70 could be connected to form graft, or prosthesis, 70′. Furthermore, many grafts 70 could be flexibly connected by connector members 100 as are desired to form graft, or prosthesis, 70′. Preferably, the length of each graft, or prosthesis, 70 is approximately the length of two slots 82; however, the length of each graft 70 could be approximately equal to the length of two or more slots 82. When three or more grafts 70 are flexibly connected by connector members 100, as shown in FIGS. 7 and 8, preferably a first connector member 100 is disposed between the second end 73 of a first tubular member 70A and the first end 72 of a second tubular member 70B. A second connector member 100 is then disposed between the second end 73 of the second tubular member 70B and the first end 72 of a third tubular member 70C. The first and second connector members 100, as shown in FIGS. 7 and 8, may be angularly offset from one another with respect to the longitudinal axis of the tubular members 70 to permit the requisite flexibility between the interconnected grafts, or prostheses, 70.
  • The delivery and expansion of graft, or prosthesis, [0039] 70′ is the same as that previously described in connection with FIGS. 1A, 1B, and 3-4. The length of the expandable, inflatable portion 84 of catheter 83 would be sized to conform with the length of the graft, or prosthesis, 70′, as should be readily apparent to one of ordinary skill in the art. Except for the length of the expandable, inflatable portion 84, catheter 83, the method of delivery of graft, or prosthesis, 70′ and its subsequent, controllable expansion and deformation are the same as previously described. As seen in FIG. 8, the prosthesis 70′ is illustrated in the configuration it would assume when being delivered to the desired location within the body passageway 80, and the graft, or prosthesis, 70′ is disposed upon catheter 83 and is passing through a curved portion of body passageway 80, such as an arterial bend. Because of the disposition of flexible connector members 100 between adjacent tubular members 71, or grafts, or prostheses, 70, graft, or prosthesis, 70′ is able to flexibly bend, or articulate, with respect to the longitudinal axis of graft, or prosthesis, 70′, so as to be able to negotiate the curves or bends found in body passageways 80. It should be noted that connector members 100 permit the bending, or articulation of adjacent tubular members in any direction about the longitudinal axis of graft, or prosthesis, 70′. When graft, or prosthesis, 70′ is in its expanded, and deformed configuration, tubular members 71 of graft, or prosthesis, 70′, will assume the configuration shown in FIG. 1B.
  • It is to be understood that the invention is not to be limited to the exact details of construction, operation, exact materials, or embodiments shown and described, as obvious modifications and equivalents will be apparent to one skilled in the art Accordingly, the invention is therefore to be limited only by the scope of the appended claims. [0040]

Claims (6)

1. An expandable intraluminal vascular graft, comprising:
a plurality of thin-walled tubular members, each having first and second ends and a wall surface disposed between the first and second ends, the wall surface having a substantially uniform thickness and a plurality of slots formed therein, the slots being disposed substantially parallel to the longitudinal axis of each tubular member;
a single connector member being disposed between adjacent tubular members to flexibly connect adjacent tubular members, the single connector member being disposed in a substantially parallel relationship with respect to the longitudinal axis of the tubular members and coplanar with each tubular member.
each tubular member having a first diameter which permits intraluminal delivery of the tubular members into a body passageway having a lumen; and
the tubular members having a second, expanded and deformed diameter, upon the application from the interior of the tubular members of a radially, outwardly extending force, which second diameter is variable and dependent upon the amount of force applied to the tubular members, whereby the tubular members may be expanded and deformed to expand the lumen of the body passageway.
2. The expandable intraluminal graft of claim 1, wherein the single connector member is a thin-walled, elongate bar member, coplanar with adjacent tubular members.
3. The expandable intraluminal graft of claim 1, wherein a first connector member is disposed between the second end of a first tubular member and the first end of a second tubular member; a second connector member is disposed between the second end of the second tubular member and the first end of a third tubular member, the first and second connector members being angularly offset from one another with respect to the longitudinal axis of the tubular members.
4. An expandable prosthesis for a body passageway, comprising:
a plurality of thin-walled tubular members, each having first and second ends and a wall surface disposed between the first and second ends, the wall surface having a substantially uniform thickness and a plurality of slots formed therein, the slots being disposed substantially parallel to the longitudinal axis of each tubular member;
a single connector member being disposed between adjacent tubular members to flexibly connect adjacent tubular members, the single connector member being disposed in a substantially parallel relationship with respect to the longitudinal axis of the tubular members and coplanar with each tubular member;
each tubular member having a first diameter which permits intraluminal delivery of the tubular members into a body passageway having a lumen; and
the tubular members having a second, expanded and deformed diameter, upon the application from the interior of the tubular members, of a radially, outwardly extending force, which second diameter is variable and dependent upon the amount of force applied to the tubular member, whereby the tubular member may be expanded and deformed to expand the lumen of the body passageway.
5. The expandable prosthesis of claim 4, wherein the single connector member is a thin-walled, elongate bar member, coplanar with adjacent tubular members.
6. The expandable prosthesis of claim 4, wherein a first connector member is disposed between the second end of a first tubular member and the first end of a second tubular member; a second connector member is disposed between the second end of the second tubular member and the first end of a third tubular member, the first and second connector members being angularly offset from one another with respect to the longitudinal axis of the tubular members.
US10/449,558 1988-10-04 2003-05-30 Expandable intraluminal graft Abandoned US20030195617A1 (en)

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US10/449,558 US20030195617A1 (en) 1988-10-04 2003-05-30 Expandable intraluminal graft
US11/293,014 US20060149353A1 (en) 1988-10-04 2005-12-02 Expandable intraluminal graft

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US25311588A 1988-10-04 1988-10-04
US10/062,869 US20020133221A1 (en) 1988-10-04 2002-01-31 Expandable intraluminal graft
US10/449,558 US20030195617A1 (en) 1988-10-04 2003-05-30 Expandable intraluminal graft

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US07/980,667 Expired - Lifetime US5902332A (en) 1988-10-04 1992-11-24 Expandable intraluminal graft
US10/062,869 Abandoned US20020133221A1 (en) 1988-10-04 2002-01-31 Expandable intraluminal graft
US10/449,558 Abandoned US20030195617A1 (en) 1988-10-04 2003-05-30 Expandable intraluminal graft
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US10/062,869 Abandoned US20020133221A1 (en) 1988-10-04 2002-01-31 Expandable intraluminal graft

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10888414B2 (en) 2019-03-20 2021-01-12 inQB8 Medical Technologies, LLC Aortic dissection implant

Families Citing this family (777)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5192307A (en) * 1987-12-08 1993-03-09 Wall W Henry Angioplasty stent
US6146358A (en) * 1989-03-14 2000-11-14 Cordis Corporation Method and apparatus for delivery of therapeutic agent
US5571169A (en) 1993-06-07 1996-11-05 Endovascular Instruments, Inc. Anti-stenotic method and product for occluded and partially occluded arteries
US5622188A (en) * 1989-08-18 1997-04-22 Endovascular Instruments, Inc. Method of restoring reduced or absent blood flow capacity in an artery
US6344053B1 (en) * 1993-12-22 2002-02-05 Medtronic Ave, Inc. Endovascular support device and method
CA2026604A1 (en) * 1989-10-02 1991-04-03 Rodney G. Wolff Articulated stent
US5477864A (en) * 1989-12-21 1995-12-26 Smith & Nephew Richards, Inc. Cardiovascular guidewire of enhanced biocompatibility
US5344426A (en) 1990-04-25 1994-09-06 Advanced Cardiovascular Systems, Inc. Method and system for stent delivery
US5236447A (en) * 1990-06-29 1993-08-17 Nissho Corporation Artificial tubular organ
DE9116881U1 (en) * 1990-10-09 1994-07-07 Cook Inc Percutaneous stent
CA2098984C (en) * 1990-12-28 2002-03-05 Ronald Sahatjian Drug delivery system
FR2671280B1 (en) * 1991-01-03 1993-03-05 Sgro Jean Claude SELF-EXHIBITING VASCULAR STENT WITH PERMANENT ELASTICITY, LOW SHORTENING AND ITS APPLICATION MATERIAL.
CA2060067A1 (en) * 1991-01-28 1992-07-29 Lilip Lau Stent delivery system
WO1992015342A1 (en) * 1991-03-08 1992-09-17 Keiji Igaki Stent for vessel, structure of holding said stent, and device for mounting said stent
USRE38653E1 (en) * 1991-03-08 2004-11-16 Kabushikikaisha Igaki Iryo Sekkei Luminal stent, holding structure therefor and device for attaching luminal stent
USRE38711E1 (en) * 1991-03-08 2005-03-15 Kabushikikaisha Igaki Iryo Sekkei Luminal stent, holding structure therefor and device for attaching luminal stent
US5356433A (en) * 1991-08-13 1994-10-18 Cordis Corporation Biocompatible metal surfaces
CA2117088A1 (en) * 1991-09-05 1993-03-18 David R. Holmes Flexible tubular device for use in medical applications
US6027863A (en) * 1991-09-05 2000-02-22 Intratherapeutics, Inc. Method for manufacturing a tubular medical device
US6107004A (en) * 1991-09-05 2000-08-22 Intra Therapeutics, Inc. Method for making a tubular stent for use in medical applications
DE69233590T2 (en) * 1991-09-12 2006-08-03 Advanced Cardiovascular Systems, Inc., Santa Clara In a limited range elastically stretchable inflatable object
US6515009B1 (en) 1991-09-27 2003-02-04 Neorx Corporation Therapeutic inhibitor of vascular smooth muscle cells
US5811447A (en) 1993-01-28 1998-09-22 Neorx Corporation Therapeutic inhibitor of vascular smooth muscle cells
US5500013A (en) * 1991-10-04 1996-03-19 Scimed Life Systems, Inc. Biodegradable drug delivery vascular stent
US5366504A (en) * 1992-05-20 1994-11-22 Boston Scientific Corporation Tubular medical prosthesis
US5354309A (en) * 1991-10-11 1994-10-11 Angiomed Ag Apparatus for widening a stenosis in a body cavity
CA2380683C (en) * 1991-10-28 2006-08-08 Advanced Cardiovascular Systems, Inc. Expandable stents and method for making same
US5316023A (en) * 1992-01-08 1994-05-31 Expandable Grafts Partnership Method for bilateral intra-aortic bypass
CA2087132A1 (en) * 1992-01-31 1993-08-01 Michael S. Williams Stent capable of attachment within a body lumen
FR2688401B1 (en) * 1992-03-12 1998-02-27 Thierry Richard EXPANDABLE STENT FOR HUMAN OR ANIMAL TUBULAR MEMBER, AND IMPLEMENTATION TOOL.
DE69326631T2 (en) * 1992-03-19 2000-06-08 Medtronic Inc Intraluminal expansion device
US5591224A (en) * 1992-03-19 1997-01-07 Medtronic, Inc. Bioelastomeric stent
US5510077A (en) * 1992-03-19 1996-04-23 Dinh; Thomas Q. Method of making an intraluminal stent
US5599352A (en) * 1992-03-19 1997-02-04 Medtronic, Inc. Method of making a drug eluting stent
US5571166A (en) * 1992-03-19 1996-11-05 Medtronic, Inc. Method of making an intraluminal stent
US6497709B1 (en) 1992-03-31 2002-12-24 Boston Scientific Corporation Metal medical device
DE69332950T2 (en) * 1992-03-31 2004-05-13 Boston Scientific Corp., Natick BLOOD VESSEL FILTER
US5496365A (en) * 1992-07-02 1996-03-05 Sgro; Jean-Claude Autoexpandable vascular endoprosthesis
US5306294A (en) * 1992-08-05 1994-04-26 Ultrasonic Sensing And Monitoring Systems, Inc. Stent construction of rolled configuration
US5382261A (en) * 1992-09-01 1995-01-17 Expandable Grafts Partnership Method and apparatus for occluding vessels
JP3739411B2 (en) * 1992-09-08 2006-01-25 敬二 伊垣 Vascular stent, manufacturing method thereof, and vascular stent device
BE1006440A3 (en) * 1992-12-21 1994-08-30 Dereume Jean Pierre Georges Em Luminal endoprosthesis AND METHOD OF PREPARATION.
EP0604022A1 (en) * 1992-12-22 1994-06-29 Advanced Cardiovascular Systems, Inc. Multilayered biodegradable stent and method for its manufacture
US5443458A (en) * 1992-12-22 1995-08-22 Advanced Cardiovascular Systems, Inc. Multilayered biodegradable stent and method of manufacture
US20050059889A1 (en) * 1996-10-16 2005-03-17 Schneider (Usa) Inc., A Minnesota Corporation Clad composite stent
US5630840A (en) 1993-01-19 1997-05-20 Schneider (Usa) Inc Clad composite stent
DE4303181A1 (en) * 1993-02-04 1994-08-11 Angiomed Ag Implantable catheter
US5360401A (en) * 1993-02-18 1994-11-01 Advanced Cardiovascular Systems, Inc. Catheter for stent delivery
JP3553067B2 (en) * 1993-04-13 2004-08-11 ボストン・サイエンティフィック・リミテッド Prosthesis introduction device with extended tip
WO1994023786A1 (en) * 1993-04-13 1994-10-27 Boston Scientific Corporation Prosthesis delivery system
US5441515A (en) * 1993-04-23 1995-08-15 Advanced Cardiovascular Systems, Inc. Ratcheting stent
US20020055710A1 (en) * 1998-04-30 2002-05-09 Ronald J. Tuch Medical device for delivering a therapeutic agent and method of preparation
US5716410A (en) * 1993-04-30 1998-02-10 Scimed Life Systems, Inc. Temporary stent and method of use
US5456667A (en) * 1993-05-20 1995-10-10 Advanced Cardiovascular Systems, Inc. Temporary stenting catheter with one-piece expandable segment
US5458615A (en) * 1993-07-06 1995-10-17 Advanced Cardiovascular Systems, Inc. Stent delivery system
DE69330132T2 (en) * 1993-07-23 2001-11-15 Cook Inc FLEXIBLE STENT WITH A CONFIGURATION MOLDED FROM A MATERIAL SHEET
US5545209A (en) * 1993-09-30 1996-08-13 Texas Petrodet, Inc. Controlled deployment of a medical device
US6685736B1 (en) * 1993-09-30 2004-02-03 Endogad Research Pty Limited Intraluminal graft
ES2217270T3 (en) 1993-09-30 2004-11-01 Endogad Research Pty Limited ENDOLUMINAL GRAFT.
US5639278A (en) * 1993-10-21 1997-06-17 Corvita Corporation Expandable supportive bifurcated endoluminal grafts
US5632772A (en) * 1993-10-21 1997-05-27 Corvita Corporation Expandable supportive branched endoluminal grafts
US5855598A (en) * 1993-10-21 1999-01-05 Corvita Corporation Expandable supportive branched endoluminal grafts
US5723004A (en) 1993-10-21 1998-03-03 Corvita Corporation Expandable supportive endoluminal grafts
US6775021B1 (en) 1993-11-26 2004-08-10 Canon Kabushiki Kaisha Data communication apparatus for receiving and recording data and having means for adding a predetermined mark and a time of reception to the recorded data
JP2703510B2 (en) 1993-12-28 1998-01-26 アドヴァンスド カーディオヴァスキュラー システムズ インコーポレーテッド Expandable stent and method of manufacturing the same
AU686315B2 (en) * 1994-02-07 1998-02-05 Kabushikikaisya Igaki Iryo Sekkei Stent device and stent supply system
US6039749A (en) 1994-02-10 2000-03-21 Endovascular Systems, Inc. Method and apparatus for deploying non-circular stents and graftstent complexes
ATE166782T1 (en) 1994-02-25 1998-06-15 Fischell Robert STENT WITH A MULTIPLE CLOSED CIRCULAR STRUCTURES
US5556413A (en) * 1994-03-11 1996-09-17 Advanced Cardiovascular Systems, Inc. Coiled stent with locking ends
US6461381B2 (en) 1994-03-17 2002-10-08 Medinol, Ltd. Flexible expandable stent
US5449373A (en) * 1994-03-17 1995-09-12 Medinol Ltd. Articulated stent
US5843120A (en) * 1994-03-17 1998-12-01 Medinol Ltd. Flexible-expandable stent
US5733303A (en) * 1994-03-17 1998-03-31 Medinol Ltd. Flexible expandable stent
US6464722B2 (en) 1994-03-17 2002-10-15 Medinol, Ltd. Flexible expandable stent
EP0997115B1 (en) * 1994-04-01 2003-10-29 Prograft Medical, Inc. Self-expandable stent and stent-graft and method of preparing them
US6165210A (en) * 1994-04-01 2000-12-26 Gore Enterprise Holdings, Inc. Self-expandable helical intravascular stent and stent-graft
US6001123A (en) * 1994-04-01 1999-12-14 Gore Enterprise Holdings Inc. Folding self-expandable intravascular stent-graft
US5693085A (en) 1994-04-29 1997-12-02 Scimed Life Systems, Inc. Stent with collagen
US5456694A (en) * 1994-05-13 1995-10-10 Stentco, Inc. Device for delivering and deploying intraluminal devices
WO1995031945A1 (en) * 1994-05-19 1995-11-30 Scimed Life Systems, Inc. Improved tissue supporting devices
US5540701A (en) * 1994-05-20 1996-07-30 Hugh Sharkey Passive fixation anastomosis method and device
DE4418336A1 (en) * 1994-05-26 1995-11-30 Angiomed Ag Stent for widening and holding open receptacles
DK63894A (en) * 1994-06-06 1996-01-08 Meadox Medicals Inc Stent catheter and method for making such a stent catheter
DE69518275T3 (en) 1994-06-08 2007-10-18 CardioVascular Concepts, Inc., Portola Valley Blood vessel graft
DE69528216T2 (en) * 1994-06-17 2003-04-17 Terumo Corp Process for the production of a permanent stent
EP0689805B1 (en) * 1994-06-27 2003-05-28 Corvita Corporation Bistable luminal graft endoprostheses
DE4424242A1 (en) 1994-07-09 1996-01-11 Ernst Peter Prof Dr M Strecker Endoprosthesis implantable percutaneously in a patient's body
US5636641A (en) 1994-07-25 1997-06-10 Advanced Cardiovascular Systems, Inc. High strength member for intracorporeal use
US6736843B1 (en) 1994-07-25 2004-05-18 Advanced Cardiovascular Systems, Inc. Cylindrically-shaped balloon-expandable stent
IL114652A (en) 1994-07-28 2000-08-31 Medinol Ltd Flexible expandable stent
US5609605A (en) * 1994-08-25 1997-03-11 Ethicon, Inc. Combination arterial stent
US6331188B1 (en) 1994-08-31 2001-12-18 Gore Enterprise Holdings, Inc. Exterior supported self-expanding stent-graft
US6015429A (en) * 1994-09-08 2000-01-18 Gore Enterprise Holdings, Inc. Procedures for introducing stents and stent-grafts
US5649977A (en) * 1994-09-22 1997-07-22 Advanced Cardiovascular Systems, Inc. Metal reinforced polymer stent
US5545210A (en) * 1994-09-22 1996-08-13 Advanced Coronary Technology, Inc. Method of implanting a permanent shape memory alloy stent
US5817152A (en) * 1994-10-19 1998-10-06 Birdsall; Matthew Connected stent apparatus
EP0794726A4 (en) * 1994-10-20 1998-01-07 Instent Inc Cystoscope delivery system
CA2175720C (en) * 1996-05-03 2011-11-29 Ian M. Penn Bifurcated stent and method for the manufacture and delivery of same
EP0790810B1 (en) * 1994-11-09 2004-04-28 Endotex Interventional Systems, Inc. Kit of delivery catheter and graft for aneurysm repair
AU3783195A (en) * 1994-11-15 1996-05-23 Advanced Cardiovascular Systems Inc. Intraluminal stent for attaching a graft
CA2301351C (en) * 1994-11-28 2002-01-22 Advanced Cardiovascular Systems, Inc. Method and apparatus for direct laser cutting of metal stents
US5755708A (en) * 1994-12-09 1998-05-26 Segal; Jerome Mechanical apparatus and method for deployment of expandable prosthesis
WO1996021404A1 (en) * 1995-01-14 1996-07-18 Prograft, Medical, Inc. Kink-resistant stent-graft
US6981986B1 (en) 1995-03-01 2006-01-03 Boston Scientific Scimed, Inc. Longitudinally flexible expandable stent
US5681345A (en) * 1995-03-01 1997-10-28 Scimed Life Systems, Inc. Sleeve carrying stent
US6818014B2 (en) 1995-03-01 2004-11-16 Scimed Life Systems, Inc. Longitudinally flexible expandable stent
ATE220308T1 (en) 1995-03-01 2002-07-15 Scimed Life Systems Inc LONGITUDONLY FLEXIBLE AND EXPANDABLE STENT
US6896696B2 (en) 1998-11-20 2005-05-24 Scimed Life Systems, Inc. Flexible and expandable stent
US20070073384A1 (en) * 1995-03-01 2007-03-29 Boston Scientific Scimed, Inc. Longitudinally flexible expandable stent
US7204848B1 (en) 1995-03-01 2007-04-17 Boston Scientific Scimed, Inc. Longitudinally flexible expandable stent
US5749851A (en) * 1995-03-02 1998-05-12 Scimed Life Systems, Inc. Stent installation method using balloon catheter having stepped compliance curve
US5556414A (en) 1995-03-08 1996-09-17 Wayne State University Composite intraluminal graft
US6053943A (en) * 1995-12-08 2000-04-25 Impra, Inc. Endoluminal graft with integral structural support and method for making same
CA2566929C (en) * 1995-03-10 2009-04-21 Bard Peripheral Vascular, Inc. Endoluminal encapsulated stent and methods of manufacture and endoluminal delivery
US6264684B1 (en) 1995-03-10 2001-07-24 Impra, Inc., A Subsidiary Of C.R. Bard, Inc. Helically supported graft
US6124523A (en) * 1995-03-10 2000-09-26 Impra, Inc. Encapsulated stent
US6039755A (en) * 1997-02-05 2000-03-21 Impra, Inc., A Division Of C.R. Bard, Inc. Radially expandable tubular polytetrafluoroethylene grafts and method of making same
US6451047B2 (en) * 1995-03-10 2002-09-17 Impra, Inc. Encapsulated intraluminal stent-graft and methods of making same
FR2733682B1 (en) 1995-05-04 1997-10-31 Dibie Alain ENDOPROSTHESIS FOR THE TREATMENT OF STENOSIS ON BIFURCATIONS OF BLOOD VESSELS AND LAYING EQUIPMENT THEREFOR
US6059810A (en) * 1995-05-10 2000-05-09 Scimed Life Systems, Inc. Endovascular stent and method
EP0831753B1 (en) 1995-06-01 2005-12-28 Meadox Medicals, Inc. Implantable intraluminal prosthesis
US5593442A (en) * 1995-06-05 1997-01-14 Localmed, Inc. Radially expansible and articulated vessel scaffold
US6602281B1 (en) * 1995-06-05 2003-08-05 Avantec Vascular Corporation Radially expansible vessel scaffold having beams and expansion joints
US5603722A (en) * 1995-06-06 1997-02-18 Quanam Medical Corporation Intravascular stent
US5954744A (en) * 1995-06-06 1999-09-21 Quanam Medical Corporation Intravascular stent
US5674242A (en) * 1995-06-06 1997-10-07 Quanam Medical Corporation Endoprosthetic device with therapeutic compound
US5788707A (en) 1995-06-07 1998-08-04 Scimed Life Systems, Inc. Pull back sleeve system with compression resistant inner shaft
US5728131A (en) * 1995-06-12 1998-03-17 Endotex Interventional Systems, Inc. Coupling device and method of use
US5782907A (en) * 1995-07-13 1998-07-21 Devices For Vascular Intervention, Inc. Involuted spring stent and graft assembly and method of use
FR2733689B1 (en) * 1995-08-07 1997-08-01 Dibie Alain SYSTEM FOR THE EXPANSION OF BLOOD VESSELS
EP0850030B1 (en) 1995-08-24 2004-07-21 Bard Peripheral Vascular, Inc. Method of assembly of a covered endoluminal stent
US5776141A (en) * 1995-08-28 1998-07-07 Localmed, Inc. Method and apparatus for intraluminal prosthesis delivery
DE19537872C2 (en) * 1995-10-11 2003-06-18 Eckhard Alt Expandable stent and method of making it
WO1997014375A1 (en) * 1995-10-20 1997-04-24 Bandula Wijay Vascular stent
DE19540084A1 (en) * 1995-10-27 1997-04-30 Figulla Hans Reiner Prof Dr Me Device for applying a stent
US5788558A (en) * 1995-11-13 1998-08-04 Localmed, Inc. Apparatus and method for polishing lumenal prostheses
US5741293A (en) * 1995-11-28 1998-04-21 Wijay; Bandula Locking stent
US5807327A (en) 1995-12-08 1998-09-15 Ethicon, Inc. Catheter assembly
WO1997021400A1 (en) * 1995-12-11 1997-06-19 Guerin Yves Francois Device for implanting a vascular endoprosthesis
EP0950385A3 (en) 1995-12-14 1999-10-27 Prograft Medical, Inc. Stent-graft deployment apparatus and method
US6042605A (en) 1995-12-14 2000-03-28 Gore Enterprose Holdings, Inc. Kink resistant stent-graft
US6203569B1 (en) 1996-01-04 2001-03-20 Bandula Wijay Flexible stent
US5980553A (en) * 1996-12-20 1999-11-09 Cordis Corporation Axially flexible stent
US5938682A (en) * 1996-01-26 1999-08-17 Cordis Corporation Axially flexible stent
US6258116B1 (en) 1996-01-26 2001-07-10 Cordis Corporation Bifurcated axially flexible stent
US5895406A (en) * 1996-01-26 1999-04-20 Cordis Corporation Axially flexible stent
US5695516A (en) * 1996-02-21 1997-12-09 Iso Stent, Inc. Longitudinally elongating balloon expandable stent
CA2192520A1 (en) 1996-03-05 1997-09-05 Ian M. Penn Expandable stent and method for delivery of same
WO1997032544A1 (en) 1996-03-05 1997-09-12 Divysio Solutions Ulc. Expandable stent and method for delivery of same
US6796997B1 (en) 1996-03-05 2004-09-28 Evysio Medical Devices Ulc Expandable stent
DE69729137T2 (en) 1996-03-10 2005-05-12 Terumo K.K. Stent for implantation
US5707387A (en) * 1996-03-25 1998-01-13 Wijay; Bandula Flexible stent
US5725548A (en) * 1996-04-08 1998-03-10 Iowa India Investments Company Limited Self-locking stent and method for its production
US5833699A (en) * 1996-04-10 1998-11-10 Chuter; Timothy A. M. Extending ribbon stent
NZ331269A (en) * 1996-04-10 2000-01-28 Advanced Cardiovascular System Expandable stent, its structural strength varying along its length
DE69702281T2 (en) * 1996-04-16 2001-02-22 Medtronic Inc Welded sinusoidal stent
BE1010183A3 (en) 1996-04-25 1998-02-03 Dereume Jean Pierre Georges Em Luminal endoprosthesis FOR BRANCHING CHANNELS OF A HUMAN OR ANIMAL BODY AND MANUFACTURING METHOD THEREOF.
US6241760B1 (en) * 1996-04-26 2001-06-05 G. David Jang Intravascular stent
US6235053B1 (en) 1998-02-02 2001-05-22 G. David Jang Tubular stent consists of chevron-shape expansion struts and contralaterally attached diagonal connectors
US20040106985A1 (en) 1996-04-26 2004-06-03 Jang G. David Intravascular stent
US6152957A (en) * 1996-04-26 2000-11-28 Jang; G. David Intravascular stent
JP4636634B2 (en) 1996-04-26 2011-02-23 ボストン サイエンティフィック サイムド,インコーポレイテッド Intravascular stent
FR2748199B1 (en) 1996-05-02 1998-10-09 Braun Celsa Sa TRANSCUTANEOUS SURGICAL ANASTOMOSABLE VASCULAR PROSTHESIS
AU2821597A (en) * 1996-05-03 1997-11-26 Emed Corporation Combined coronary stent deployment and local delivery of an agent
US6027528A (en) * 1996-05-28 2000-02-22 Cordis Corporation Composite material endoprosthesis
US5733326A (en) * 1996-05-28 1998-03-31 Cordis Corporation Composite material endoprosthesis
US8728143B2 (en) * 1996-06-06 2014-05-20 Biosensors International Group, Ltd. Endoprosthesis deployment system for treating vascular bifurcations
US7238197B2 (en) * 2000-05-30 2007-07-03 Devax, Inc. Endoprosthesis deployment system for treating vascular bifurcations
US7686846B2 (en) * 1996-06-06 2010-03-30 Devax, Inc. Bifurcation stent and method of positioning in a body lumen
US6666883B1 (en) 1996-06-06 2003-12-23 Jacques Seguin Endoprosthesis for vascular bifurcation
HU217501B (en) 1996-07-31 2000-02-28 László Major Enlarging facing for blood-vessels
US5755781A (en) * 1996-08-06 1998-05-26 Iowa-India Investments Company Limited Embodiments of multiple interconnected stents
IL119189A0 (en) * 1996-09-03 1996-12-05 Lev Shlomo Annulus catheter
US5911752A (en) * 1996-09-13 1999-06-15 Intratherapeutics, Inc. Method for collapsing a stent
US5807404A (en) * 1996-09-19 1998-09-15 Medinol Ltd. Stent with variable features to optimize support and method of making such stent
US5755776A (en) * 1996-10-04 1998-05-26 Al-Saadon; Khalid Permanent expandable intraluminal tubular stent
US7749585B2 (en) * 1996-10-08 2010-07-06 Alan Zamore Reduced profile medical balloon element
AU7304296A (en) * 1996-10-11 1998-05-11 Alain Fouere Flexible expandable tube for surgical dilating of physiological ducts
DE19653719C2 (en) * 1996-10-28 1999-06-24 Biotronik Mess & Therapieg Expandable intraluminal device
DE19653709C2 (en) * 1996-10-28 1999-07-01 Biotronik Mess & Therapieg Stent
DE19653718C2 (en) * 1996-10-28 1999-06-24 Biotronik Mess & Therapieg Stent
WO1998018405A1 (en) 1996-10-28 1998-05-07 Biotronik Mess- Und Therapiegeräte Gmbh & Co. Expandable interluminal device
US5968093A (en) * 1996-10-28 1999-10-19 Biotronik Mess-And Therapiegerate Gmbh & Co. Stent
WO1998018404A1 (en) 1996-10-28 1998-05-07 Biotronik Mess- Und Therapiegeräte Gmbh & Co. Stent
DE19653717C2 (en) * 1996-10-28 1999-02-25 Biotronik Mess & Therapieg Expandable intraluminal device
US6835203B1 (en) * 1996-11-04 2004-12-28 Advanced Stent Technologies, Inc. Extendible stent apparatus
EP1723931B1 (en) * 1996-11-04 2012-01-04 Advanced Stent Technologies, Inc. Extendible stent apparatus and method for deploying the same
US7591846B2 (en) 1996-11-04 2009-09-22 Boston Scientific Scimed, Inc. Methods for deploying stents in bifurcations
US6692483B2 (en) 1996-11-04 2004-02-17 Advanced Stent Technologies, Inc. Catheter with attached flexible side sheath
US7341598B2 (en) 1999-01-13 2008-03-11 Boston Scientific Scimed, Inc. Stent with protruding branch portion for bifurcated vessels
US8211167B2 (en) 1999-12-06 2012-07-03 Boston Scientific Scimed, Inc. Method of using a catheter with attached flexible side sheath
WO1998020810A1 (en) 1996-11-12 1998-05-22 Medtronic, Inc. Flexible, radially expansible luminal prostheses
DE29620088U1 (en) * 1996-11-19 1998-03-19 Starck Bernd Dipl Ing Implantable stent
DE19653720A1 (en) 1996-12-10 1998-06-18 Biotronik Mess & Therapieg Stent
US6551350B1 (en) * 1996-12-23 2003-04-22 Gore Enterprise Holdings, Inc. Kink resistant bifurcated prosthesis
US6352561B1 (en) 1996-12-23 2002-03-05 W. L. Gore & Associates Implant deployment apparatus
US5868782A (en) * 1996-12-24 1999-02-09 Global Therapeutics, Inc. Radially expandable axially non-contracting surgical stent
US7959664B2 (en) * 1996-12-26 2011-06-14 Medinol, Ltd. Flat process of drug coating for stents
US5906759A (en) * 1996-12-26 1999-05-25 Medinol Ltd. Stent forming apparatus with stent deforming blades
US5951566A (en) * 1997-01-02 1999-09-14 Lev; Shlomo Annular catheter
US5925061A (en) * 1997-01-13 1999-07-20 Gore Enterprise Holdings, Inc. Low profile vascular stent
US5961545A (en) * 1997-01-17 1999-10-05 Meadox Medicals, Inc. EPTFE graft-stent composite device
US8353948B2 (en) 1997-01-24 2013-01-15 Celonova Stent, Inc. Fracture-resistant helical stent incorporating bistable cells and methods of use
US8663311B2 (en) 1997-01-24 2014-03-04 Celonova Stent, Inc. Device comprising biodegradable bistable or multistable cells and methods of use
CN1626048B (en) 1997-01-24 2012-09-12 帕拉贡知识产权有限责任公司 Expandable device having bistable spring construction
GB9703859D0 (en) 1997-02-25 1997-04-16 Plante Sylvain Expandable intravascular stent
WO1998038946A1 (en) * 1997-03-05 1998-09-11 Stent Tech, Inc. Expandable and self-expanding stents and methods of making and using the same
US20020133222A1 (en) * 1997-03-05 2002-09-19 Das Gladwin S. Expandable stent having a plurality of interconnected expansion modules
US5911732A (en) * 1997-03-10 1999-06-15 Johnson & Johnson Interventional Systems, Co. Articulated expandable intraluminal stent
US5815904A (en) * 1997-03-13 1998-10-06 Intratherapeutics, Inc. Method for making a stent
US5843168A (en) * 1997-03-31 1998-12-01 Medtronic, Inc. Double wave stent with strut
US5902475A (en) 1997-04-08 1999-05-11 Interventional Technologies, Inc. Method for manufacturing a stent
US6726829B2 (en) 1997-04-08 2004-04-27 Scimed Life Systems, Inc. Method of manufacturing a stent
US5718713A (en) * 1997-04-10 1998-02-17 Global Therapeutics, Inc. Surgical stent having a streamlined contour
US8172897B2 (en) 1997-04-15 2012-05-08 Advanced Cardiovascular Systems, Inc. Polymer and metal composite implantable medical devices
US6240616B1 (en) 1997-04-15 2001-06-05 Advanced Cardiovascular Systems, Inc. Method of manufacturing a medicated porous metal prosthesis
US10028851B2 (en) 1997-04-15 2018-07-24 Advanced Cardiovascular Systems, Inc. Coatings for controlling erosion of a substrate of an implantable medical device
US6019777A (en) 1997-04-21 2000-02-01 Advanced Cardiovascular Systems, Inc. Catheter and method for a stent delivery system
US6143016A (en) * 1997-04-21 2000-11-07 Advanced Cardiovascular Systems, Inc. Sheath and method of use for a stent delivery system
US6033433A (en) * 1997-04-25 2000-03-07 Scimed Life Systems, Inc. Stent configurations including spirals
US5741327A (en) 1997-05-06 1998-04-21 Global Therapeutics, Inc. Surgical stent featuring radiopaque markers
DE19722857A1 (en) 1997-05-23 1998-11-26 Biotronik Mess & Therapieg Stent
DE19722384A1 (en) * 1997-05-28 1998-12-03 Gfe Ges Fuer Forschung Und Ent Flexible expandable stent
US5746691A (en) * 1997-06-06 1998-05-05 Global Therapeutics, Inc. Method for polishing surgical stents
EP0884029B1 (en) * 1997-06-13 2004-12-22 Gary J. Becker Expandable intraluminal endoprosthesis
US5843175A (en) * 1997-06-13 1998-12-01 Global Therapeutics, Inc. Enhanced flexibility surgical stent
US6004328A (en) * 1997-06-19 1999-12-21 Solar; Ronald J. Radially expandable intraluminal stent and delivery catheter therefore and method of using the same
CA2241558A1 (en) 1997-06-24 1998-12-24 Advanced Cardiovascular Systems, Inc. Stent with reinforced struts and bimodal deployment
DE59711236D1 (en) 1997-06-30 2004-02-26 Medex Holding Gmbh Intraluminal implant
DE19728337A1 (en) * 1997-07-03 1999-01-07 Inst Mikrotechnik Mainz Gmbh Implantable stent
US6070589A (en) 1997-08-01 2000-06-06 Teramed, Inc. Methods for deploying bypass graft stents
US5824059A (en) * 1997-08-05 1998-10-20 Wijay; Bandula Flexible stent
AU741328B2 (en) * 1997-08-08 2001-11-29 Sunscope International, Inc. Microporous stent and implantation device
US6165195A (en) * 1997-08-13 2000-12-26 Advanced Cardiovascylar Systems, Inc. Stent and catheter assembly and method for treating bifurcations
US7753950B2 (en) 1997-08-13 2010-07-13 Advanced Cardiovascular Systems, Inc. Stent and catheter assembly and method for treating bifurcations
US6746476B1 (en) * 1997-09-22 2004-06-08 Cordis Corporation Bifurcated axially flexible stent
DE69838256T2 (en) 1997-09-24 2008-05-15 Med Institute, Inc., West Lafayette RADIAL EXPANDABLE STENT
US6042606A (en) * 1997-09-29 2000-03-28 Cook Incorporated Radially expandable non-axially contracting surgical stent
US6071308A (en) 1997-10-01 2000-06-06 Boston Scientific Corporation Flexible metal wire stent
US5967986A (en) * 1997-11-25 1999-10-19 Vascusense, Inc. Endoluminal implant with fluid flow sensing capability
CA2308177C (en) 1997-11-07 2005-01-25 Expandable Grafts Partnership Intravascular stent and method for manufacturing an intravascular stent
US6395019B2 (en) * 1998-02-09 2002-05-28 Trivascular, Inc. Endovascular graft
US6033436A (en) * 1998-02-17 2000-03-07 Md3, Inc. Expandable stent
US6224626B1 (en) 1998-02-17 2001-05-01 Md3, Inc. Ultra-thin expandable stent
US20070142901A1 (en) * 1998-02-17 2007-06-21 Steinke Thomas A Expandable stent with sliding and locking radial elements
US6623521B2 (en) 1998-02-17 2003-09-23 Md3, Inc. Expandable stent with sliding and locking radial elements
US6140127A (en) * 1998-02-18 2000-10-31 Cordis Corporation Method of coating an intravascular stent with an endothelial cell adhesive five amino acid peptide
US5931866A (en) * 1998-02-24 1999-08-03 Frantzen; John J. Radially expandable stent featuring accordion stops
US6280467B1 (en) * 1998-02-26 2001-08-28 World Medical Manufacturing Corporation Delivery system for deployment and endovascular assembly of a multi-stage stented graft
JP4801838B2 (en) 1998-03-05 2011-10-26 ボストン サイエンティフィック リミテッド Intraluminal stent
US6110188A (en) * 1998-03-09 2000-08-29 Corvascular, Inc. Anastomosis method
US6241741B1 (en) * 1998-03-09 2001-06-05 Corvascular Surgical Systems, Inc. Anastomosis device and method
US6176864B1 (en) 1998-03-09 2001-01-23 Corvascular, Inc. Anastomosis device and method
US6132461A (en) 1998-03-27 2000-10-17 Intratherapeutics, Inc. Stent with dual support structure
US6132460A (en) 1998-03-27 2000-10-17 Intratherapeutics, Inc. Stent
US6558415B2 (en) * 1998-03-27 2003-05-06 Intratherapeutics, Inc. Stent
US20040254635A1 (en) * 1998-03-30 2004-12-16 Shanley John F. Expandable medical device for delivery of beneficial agent
US6656215B1 (en) * 2000-11-16 2003-12-02 Cordis Corporation Stent graft having an improved means for attaching a stent to a graft
US7208011B2 (en) * 2001-08-20 2007-04-24 Conor Medsystems, Inc. Implantable medical device with drug filled holes
US6290731B1 (en) 1998-03-30 2001-09-18 Cordis Corporation Aortic graft having a precursor gasket for repairing an abdominal aortic aneurysm
US6241762B1 (en) * 1998-03-30 2001-06-05 Conor Medsystems, Inc. Expandable medical device with ductile hinges
US6887268B2 (en) 1998-03-30 2005-05-03 Cordis Corporation Extension prosthesis for an arterial repair
US7208010B2 (en) * 2000-10-16 2007-04-24 Conor Medsystems, Inc. Expandable medical device for delivery of beneficial agent
US6019789A (en) * 1998-04-01 2000-02-01 Quanam Medical Corporation Expandable unit cell and intraluminal stent
US20020099438A1 (en) * 1998-04-15 2002-07-25 Furst Joseph G. Irradiated stent coating
US6436133B1 (en) 1998-04-15 2002-08-20 Joseph G. Furst Expandable graft
US20030040790A1 (en) * 1998-04-15 2003-02-27 Furst Joseph G. Stent coating
US6264687B1 (en) 1998-04-20 2001-07-24 Cordis Corporation Multi-laminate stent having superelastic articulated sections
US6093203A (en) 1998-05-13 2000-07-25 Uflacker; Renan Stent or graft support structure for treating bifurcated vessels having different diameter portions and methods of use and implantation
US6296603B1 (en) 1998-05-26 2001-10-02 Isostent, Inc. Radioactive intraluminal endovascular prosthesis and method for the treatment of aneurysms
US6099559A (en) 1998-05-28 2000-08-08 Medtronic Ave, Inc. Endoluminal support assembly with capped ends
US6171334B1 (en) 1998-06-17 2001-01-09 Advanced Cardiovascular Systems, Inc. Expandable stent and method of use
US6369039B1 (en) * 1998-06-30 2002-04-09 Scimed Life Sytems, Inc. High efficiency local drug delivery
US6261319B1 (en) 1998-07-08 2001-07-17 Scimed Life Systems, Inc. Stent
US6136011A (en) * 1998-07-14 2000-10-24 Advanced Cardiovascular Systems, Inc. Stent delivery system and method of use
US7967855B2 (en) * 1998-07-27 2011-06-28 Icon Interventional Systems, Inc. Coated medical device
US8070796B2 (en) 1998-07-27 2011-12-06 Icon Interventional Systems, Inc. Thrombosis inhibiting graft
US6461380B1 (en) 1998-07-28 2002-10-08 Advanced Cardiovascular Systems, Inc. Stent configuration
US6117104A (en) * 1998-09-08 2000-09-12 Advanced Cardiovascular Systems, Inc. Stent deployment system and method of use
US6193744B1 (en) * 1998-09-10 2001-02-27 Scimed Life Systems, Inc. Stent configurations
US6042597A (en) * 1998-10-23 2000-03-28 Scimed Life Systems, Inc. Helical stent design
US6293967B1 (en) 1998-10-29 2001-09-25 Conor Medsystems, Inc. Expandable medical device with ductile hinges
US6190403B1 (en) 1998-11-13 2001-02-20 Cordis Corporation Low profile radiopaque stent with increased longitudinal flexibility and radial rigidity
US6083259A (en) * 1998-11-16 2000-07-04 Frantzen; John J. Axially non-contracting flexible radially expandable stent
WO2000030563A1 (en) 1998-11-20 2000-06-02 Scimed Life Systems, Inc. Longitudinally flexible expandable stent
US20040267349A1 (en) 2003-06-27 2004-12-30 Kobi Richter Amorphous metal alloy medical devices
US20060122691A1 (en) * 1998-12-03 2006-06-08 Jacob Richter Hybrid stent
US8382821B2 (en) 1998-12-03 2013-02-26 Medinol Ltd. Helical hybrid stent
US20060178727A1 (en) * 1998-12-03 2006-08-10 Jacob Richter Hybrid amorphous metal alloy stent
SG75982A1 (en) * 1998-12-03 2000-10-24 Medinol Ltd Controlled detachment stents
US6340366B2 (en) 1998-12-08 2002-01-22 Bandula Wijay Stent with nested or overlapping rings
US6743252B1 (en) 1998-12-18 2004-06-01 Cook Incorporated Cannula stent
CA2349256C (en) 1998-12-18 2009-04-14 Cook Incorporated Cannula stent
US7655030B2 (en) 2003-07-18 2010-02-02 Boston Scientific Scimed, Inc. Catheter balloon systems and methods
US20050060027A1 (en) * 1999-01-13 2005-03-17 Advanced Stent Technologies, Inc. Catheter balloon systems and methods
US6022359A (en) * 1999-01-13 2000-02-08 Frantzen; John J. Stent delivery system featuring a flexible balloon
US6187034B1 (en) 1999-01-13 2001-02-13 John J. Frantzen Segmented stent for flexible stent delivery system
WO2000044309A2 (en) 1999-02-01 2000-08-03 Board Of Regents, The University Of Texas System Woven bifurcated and trifurcated stents and methods for making the same
US7018401B1 (en) * 1999-02-01 2006-03-28 Board Of Regents, The University Of Texas System Woven intravascular devices and methods for making the same and apparatus for delivery of the same
US6398803B1 (en) 1999-02-02 2002-06-04 Impra, Inc., A Subsidiary Of C.R. Bard, Inc. Partial encapsulation of stents
US6274294B1 (en) 1999-02-03 2001-08-14 Electroformed Stents, Inc. Cylindrical photolithography exposure process and apparatus
US6251134B1 (en) * 1999-02-28 2001-06-26 Inflow Dynamics Inc. Stent with high longitudinal flexibility
US7029492B1 (en) 1999-03-05 2006-04-18 Terumo Kabushiki Kaisha Implanting stent and dilating device
US6273910B1 (en) 1999-03-11 2001-08-14 Advanced Cardiovascular Systems, Inc. Stent with varying strut geometry
US6287333B1 (en) 1999-03-15 2001-09-11 Angiodynamics, Inc. Flexible stent
US6709465B2 (en) 1999-03-18 2004-03-23 Fossa Medical, Inc. Radially expanding ureteral device
US7214229B2 (en) 1999-03-18 2007-05-08 Fossa Medical, Inc. Radially expanding stents
US6425855B2 (en) 1999-04-06 2002-07-30 Cordis Corporation Method for making a multi-laminate stent having superelastic articulated sections
US6325825B1 (en) * 1999-04-08 2001-12-04 Cordis Corporation Stent with variable wall thickness
US6273911B1 (en) 1999-04-22 2001-08-14 Advanced Cardiovascular Systems, Inc. Variable strength stent
US6290673B1 (en) 1999-05-20 2001-09-18 Conor Medsystems, Inc. Expandable medical device delivery system and method
US7387639B2 (en) * 1999-06-04 2008-06-17 Advanced Stent Technologies, Inc. Short sleeve stent delivery catheter and methods
US6884258B2 (en) 1999-06-04 2005-04-26 Advanced Stent Technologies, Inc. Bifurcation lesion stent delivery using multiple guidewires
US6258121B1 (en) 1999-07-02 2001-07-10 Scimed Life Systems, Inc. Stent coating
US6540774B1 (en) 1999-08-31 2003-04-01 Advanced Cardiovascular Systems, Inc. Stent design with end rings having enhanced strength and radiopacity
US6254631B1 (en) 1999-09-23 2001-07-03 Intratherapeutics, Inc. Stent with enhanced friction
DE19951475A1 (en) 1999-10-26 2001-05-10 Biotronik Mess & Therapieg Stent
DE19951607A1 (en) 1999-10-26 2001-05-10 Biotronik Mess & Therapieg Stent with a closed structure
US6325823B1 (en) * 1999-10-29 2001-12-04 Revasc Corporation Endovascular prosthesis accommodating torsional and longitudinal displacements and methods of use
US6287291B1 (en) 1999-11-09 2001-09-11 Advanced Cardiovascular Systems, Inc. Protective sheath for catheters
US6475235B1 (en) 1999-11-16 2002-11-05 Iowa-India Investments Company, Limited Encapsulated stent preform
US7736687B2 (en) 2006-01-31 2010-06-15 Advance Bio Prosthetic Surfaces, Ltd. Methods of making medical devices
US8458879B2 (en) * 2001-07-03 2013-06-11 Advanced Bio Prosthetic Surfaces, Ltd., A Wholly Owned Subsidiary Of Palmaz Scientific, Inc. Method of fabricating an implantable medical device
US10172730B2 (en) * 1999-11-19 2019-01-08 Vactronix Scientific, Llc Stents with metallic covers and methods of making same
US6537310B1 (en) 1999-11-19 2003-03-25 Advanced Bio Prosthetic Surfaces, Ltd. Endoluminal implantable devices and method of making same
US20030130671A1 (en) * 1999-11-23 2003-07-10 Duhaylongsod Francis G. Anastomosis device and method
US6702849B1 (en) 1999-12-13 2004-03-09 Advanced Cardiovascular Systems, Inc. Method of processing open-celled microcellular polymeric foams with controlled porosity for use as vascular grafts and stent covers
US6355058B1 (en) 1999-12-30 2002-03-12 Advanced Cardiovascular Systems, Inc. Stent with radiopaque coating consisting of particles in a binder
US6471721B1 (en) 1999-12-30 2002-10-29 Advanced Cardiovascular Systems, Inc. Vascular stent having increased radiopacity and method for making same
US6537311B1 (en) 1999-12-30 2003-03-25 Advanced Cardiovascular Systems, Inc. Stent designs for use in peripheral vessels
EP1132058A1 (en) * 2000-03-06 2001-09-12 Advanced Laser Applications Holding S.A. Intravascular prothesis
US6379382B1 (en) 2000-03-13 2002-04-30 Jun Yang Stent having cover with drug delivery capability
US6613082B2 (en) 2000-03-13 2003-09-02 Jun Yang Stent having cover with drug delivery capability
US6436132B1 (en) 2000-03-30 2002-08-20 Advanced Cardiovascular Systems, Inc. Composite intraluminal prostheses
US7875283B2 (en) 2000-04-13 2011-01-25 Advanced Cardiovascular Systems, Inc. Biodegradable polymers for use with implantable medical devices
US8109994B2 (en) 2003-01-10 2012-02-07 Abbott Cardiovascular Systems, Inc. Biodegradable drug delivery material for stent
US6527801B1 (en) 2000-04-13 2003-03-04 Advanced Cardiovascular Systems, Inc. Biodegradable drug delivery material for stent
US8236048B2 (en) * 2000-05-12 2012-08-07 Cordis Corporation Drug/drug delivery systems for the prevention and treatment of vascular disease
US6776796B2 (en) 2000-05-12 2004-08-17 Cordis Corportation Antiinflammatory drug and delivery device
US20050002986A1 (en) * 2000-05-12 2005-01-06 Robert Falotico Drug/drug delivery systems for the prevention and treatment of vascular disease
US20040243097A1 (en) * 2000-05-12 2004-12-02 Robert Falotico Antiproliferative drug and delivery device
US7181261B2 (en) * 2000-05-15 2007-02-20 Silver James H Implantable, retrievable, thrombus minimizing sensors
US7006858B2 (en) 2000-05-15 2006-02-28 Silver James H Implantable, retrievable sensors and immunosensors
US7769420B2 (en) * 2000-05-15 2010-08-03 Silver James H Sensors for detecting substances indicative of stroke, ischemia, or myocardial infarction
US6442413B1 (en) 2000-05-15 2002-08-27 James H. Silver Implantable sensor
US8133698B2 (en) * 2000-05-15 2012-03-13 Silver James H Sensors for detecting substances indicative of stroke, ischemia, infection or inflammation
US8632583B2 (en) 2011-05-09 2014-01-21 Palmaz Scientific, Inc. Implantable medical device having enhanced endothelial migration features and methods of making the same
EP1359865B1 (en) 2000-05-19 2006-11-22 Advanced Bio Prosthetic Surfaces, Ltd. Methods and apparatus for manufacturing an intravascular stent
US20030139803A1 (en) * 2000-05-30 2003-07-24 Jacques Sequin Method of stenting a vessel with stent lumenal diameter increasing distally
US6652579B1 (en) 2000-06-22 2003-11-25 Advanced Cardiovascular Systems, Inc. Radiopaque stent
US6540775B1 (en) 2000-06-30 2003-04-01 Cordis Corporation Ultraflexible open cell stent
US6799637B2 (en) 2000-10-20 2004-10-05 Schlumberger Technology Corporation Expandable tubing and method
WO2002015824A2 (en) * 2000-08-25 2002-02-28 Kensey Nash Corporation Covered stents, systems for deploying covered stents
US20020116049A1 (en) * 2000-09-22 2002-08-22 Scimed Life Systems, Inc. Stent
US6699278B2 (en) 2000-09-22 2004-03-02 Cordis Corporation Stent with optimal strength and radiopacity characteristics
US8070792B2 (en) 2000-09-22 2011-12-06 Boston Scientific Scimed, Inc. Stent
US7766956B2 (en) * 2000-09-22 2010-08-03 Boston Scientific Scimed, Inc. Intravascular stent and assembly
US6695833B1 (en) * 2000-09-27 2004-02-24 Nellix, Inc. Vascular stent-graft apparatus and forming method
US6652574B1 (en) 2000-09-28 2003-11-25 Vascular Concepts Holdings Limited Product and process for manufacturing a wire stent coated with a biocompatible fluoropolymer
ATE343969T1 (en) 2000-09-29 2006-11-15 Cordis Corp COATED MEDICAL DEVICES
US20020051730A1 (en) * 2000-09-29 2002-05-02 Stanko Bodnar Coated medical devices and sterilization thereof
US7261735B2 (en) 2001-05-07 2007-08-28 Cordis Corporation Local drug delivery devices and methods for maintaining the drug coatings thereon
US20020111590A1 (en) * 2000-09-29 2002-08-15 Davila Luis A. Medical devices, drug coatings and methods for maintaining the drug coatings thereon
US6764507B2 (en) 2000-10-16 2004-07-20 Conor Medsystems, Inc. Expandable medical device with improved spatial distribution
DE60112318D1 (en) 2000-10-16 2005-09-01 Conor Medsystems Inc EXPANDABLE MEDICAL DEVICE FOR DELIVERING A REMEDY
US6416540B1 (en) 2000-11-01 2002-07-09 Sandip V. Mathur Magnetically actuated cleanable stent and method
US7267685B2 (en) 2000-11-16 2007-09-11 Cordis Corporation Bilateral extension prosthesis and method of delivery
US6843802B1 (en) 2000-11-16 2005-01-18 Cordis Corporation Delivery apparatus for a self expanding retractable stent
US7314483B2 (en) * 2000-11-16 2008-01-01 Cordis Corp. Stent graft with branch leg
US7229472B2 (en) 2000-11-16 2007-06-12 Cordis Corporation Thoracic aneurysm repair prosthesis and system
US6942692B2 (en) 2000-11-16 2005-09-13 Cordis Corporation Supra-renal prosthesis and renal artery bypass
US6544219B2 (en) 2000-12-15 2003-04-08 Advanced Cardiovascular Systems, Inc. Catheter for placement of therapeutic devices at the ostium of a bifurcation of a body lumen
US20020103526A1 (en) * 2000-12-15 2002-08-01 Tom Steinke Protective coating for stent
US6764504B2 (en) 2001-01-04 2004-07-20 Scimed Life Systems, Inc. Combined shaped balloon and stent protector
AU2002219569B2 (en) 2001-01-15 2005-05-05 Terumo Kabushiki Kaisha Stent
NO335594B1 (en) 2001-01-16 2015-01-12 Halliburton Energy Serv Inc Expandable devices and methods thereof
US6964680B2 (en) * 2001-02-05 2005-11-15 Conor Medsystems, Inc. Expandable medical device with tapered hinge
US20040073294A1 (en) * 2002-09-20 2004-04-15 Conor Medsystems, Inc. Method and apparatus for loading a beneficial agent into an expandable medical device
DE10105592A1 (en) * 2001-02-06 2002-08-08 Achim Goepferich Placeholder for drug release in the frontal sinus
US6740114B2 (en) 2001-03-01 2004-05-25 Cordis Corporation Flexible stent
US6679911B2 (en) 2001-03-01 2004-01-20 Cordis Corporation Flexible stent
US6790227B2 (en) * 2001-03-01 2004-09-14 Cordis Corporation Flexible stent
AU784552B2 (en) * 2001-03-02 2006-05-04 Cardinal Health 529, Llc Flexible stent
CA2441061A1 (en) * 2001-03-20 2002-09-26 Gmp Cardiac Care, Inc. Rail stent
EP1258230A3 (en) 2001-03-29 2003-12-10 CardioSafe Ltd Balloon catheter device
EP1245203B1 (en) 2001-03-30 2006-03-08 Terumo Kabushiki Kaisha Stent
DE10118944B4 (en) * 2001-04-18 2013-01-31 Merit Medical Systems, Inc. Removable, essentially cylindrical implants
US6719795B1 (en) * 2001-04-25 2004-04-13 Macropore Biosurgery, Inc. Resorbable posterior spinal fusion system
US8182527B2 (en) * 2001-05-07 2012-05-22 Cordis Corporation Heparin barrier coating for controlled drug release
BR0103255A (en) 2001-05-16 2003-05-20 Christiane Dias Maues Cylindrical tubular prosthetic device; and prosthetic device with biological cover for drug release; and its intraluminal splitting system
US8617231B2 (en) * 2001-05-18 2013-12-31 Boston Scientific Scimed, Inc. Dual guidewire exchange catheter system
KR20020094074A (en) * 2001-06-07 2002-12-18 (주)에이치비메디컬스 Implantation tube in the body
US6927359B2 (en) 2001-06-14 2005-08-09 Advanced Cardiovascular Systems, Inc. Pulsed fiber laser cutting system for medical implants
US6521865B1 (en) 2001-06-14 2003-02-18 Advanced Cardiovascular Systems, Inc. Pulsed fiber laser cutting system for medical implants
US7520892B1 (en) 2001-06-28 2009-04-21 Advanced Cardiovascular Systems, Inc. Low profile stent with flexible link
US6605110B2 (en) 2001-06-29 2003-08-12 Advanced Cardiovascular Systems, Inc. Stent with enhanced bendability and flexibility
US6607554B2 (en) 2001-06-29 2003-08-19 Advanced Cardiovascular Systems, Inc. Universal stent link design
WO2003007842A2 (en) 2001-07-18 2003-01-30 Disa Vascular (Pty) Ltd Stents
US7547321B2 (en) * 2001-07-26 2009-06-16 Alveolus Inc. Removable stent and method of using the same
US7056338B2 (en) 2003-03-28 2006-06-06 Conor Medsystems, Inc. Therapeutic agent delivery device with controlled therapeutic agent release rates
US7842083B2 (en) * 2001-08-20 2010-11-30 Innovational Holdings, Llc. Expandable medical device with improved spatial distribution
US20040137066A1 (en) * 2001-11-26 2004-07-15 Swaminathan Jayaraman Rationally designed therapeutic intravascular implant coating
GB0121980D0 (en) 2001-09-11 2001-10-31 Cathnet Science Holding As Expandable stent
US7252679B2 (en) * 2001-09-13 2007-08-07 Cordis Corporation Stent with angulated struts
US7989018B2 (en) 2001-09-17 2011-08-02 Advanced Cardiovascular Systems, Inc. Fluid treatment of a polymeric coating on an implantable medical device
US7285304B1 (en) 2003-06-25 2007-10-23 Advanced Cardiovascular Systems, Inc. Fluid treatment of a polymeric coating on an implantable medical device
US6863683B2 (en) 2001-09-19 2005-03-08 Abbott Laboratoris Vascular Entities Limited Cold-molding process for loading a stent onto a stent delivery system
US7195640B2 (en) * 2001-09-25 2007-03-27 Cordis Corporation Coated medical devices for the treatment of vulnerable plaque
US20030065345A1 (en) * 2001-09-28 2003-04-03 Kevin Weadock Anastomosis devices and methods for treating anastomotic sites
US7108701B2 (en) * 2001-09-28 2006-09-19 Ethicon, Inc. Drug releasing anastomosis devices and methods for treating anastomotic sites
EP1434540B1 (en) 2001-10-09 2006-07-19 William Cook Europe ApS Cannula stent
US8740973B2 (en) * 2001-10-26 2014-06-03 Icon Medical Corp. Polymer biodegradable medical device
US8080048B2 (en) 2001-12-03 2011-12-20 Xtent, Inc. Stent delivery for bifurcated vessels
US20040186551A1 (en) 2003-01-17 2004-09-23 Xtent, Inc. Multiple independent nested stent structures and methods for their preparation and deployment
US7892273B2 (en) 2001-12-03 2011-02-22 Xtent, Inc. Custom length stent apparatus
US20030135266A1 (en) * 2001-12-03 2003-07-17 Xtent, Inc. Apparatus and methods for delivery of multiple distributed stents
US7270668B2 (en) 2001-12-03 2007-09-18 Xtent, Inc. Apparatus and methods for delivering coiled prostheses
US7294146B2 (en) * 2001-12-03 2007-11-13 Xtent, Inc. Apparatus and methods for delivery of variable length stents
US7137993B2 (en) 2001-12-03 2006-11-21 Xtent, Inc. Apparatus and methods for delivery of multiple distributed stents
US7147656B2 (en) 2001-12-03 2006-12-12 Xtent, Inc. Apparatus and methods for delivery of braided prostheses
US7351255B2 (en) * 2001-12-03 2008-04-01 Xtent, Inc. Stent delivery apparatus and method
US7182779B2 (en) * 2001-12-03 2007-02-27 Xtent, Inc. Apparatus and methods for positioning prostheses for deployment from a catheter
US7309350B2 (en) 2001-12-03 2007-12-18 Xtent, Inc. Apparatus and methods for deployment of vascular prostheses
JP4331610B2 (en) * 2001-12-20 2009-09-16 トリバスキュラー2,インコーポレイティド Advanced endovascular graft
US7147661B2 (en) * 2001-12-20 2006-12-12 Boston Scientific Santa Rosa Corp. Radially expandable stent
US7326237B2 (en) * 2002-01-08 2008-02-05 Cordis Corporation Supra-renal anchoring prosthesis
US7029493B2 (en) * 2002-01-25 2006-04-18 Cordis Corporation Stent with enhanced crossability
US20030187498A1 (en) * 2002-03-28 2003-10-02 Medtronic Ave, Inc. Chamfered stent strut and method of making same
AU2003223408A1 (en) * 2002-04-02 2003-10-20 Worldcom, Inc. Communications gateway with messaging communications interface
US6656220B1 (en) 2002-06-17 2003-12-02 Advanced Cardiovascular Systems, Inc. Intravascular stent
DE10233085B4 (en) * 2002-07-19 2014-02-20 Dendron Gmbh Stent with guide wire
US8425549B2 (en) 2002-07-23 2013-04-23 Reverse Medical Corporation Systems and methods for removing obstructive matter from body lumens and treating vascular defects
AU2003249309A1 (en) * 2002-07-24 2004-02-09 Advanced Stent Technologies, Inc. Stents capable of controllably releasing histone deacetylase inhibitors
US8016881B2 (en) 2002-07-31 2011-09-13 Icon Interventional Systems, Inc. Sutures and surgical staples for anastamoses, wound closures, and surgical closures
US7185034B2 (en) * 2002-08-01 2007-02-27 Oracle International Corporation Buffered message queue architecture for database management systems with guaranteed at least once delivery
MXPA05001845A (en) * 2002-08-15 2005-11-17 Gmp Cardiac Care Inc Stent-graft with rails.
AU2003257604A1 (en) 2002-08-23 2004-03-29 Bridgestone Corporation Stent and process for producing the same
WO2004026183A2 (en) 2002-09-20 2004-04-01 Nellix, Inc. Stent-graft with positioning anchor
US20040127976A1 (en) * 2002-09-20 2004-07-01 Conor Medsystems, Inc. Method and apparatus for loading a beneficial agent into an expandable medical device
EP1539043B1 (en) * 2002-09-20 2013-12-18 Innovational Holdings, LLC Expandable medical device with openings for delivery of multiple beneficial agents
US20040093056A1 (en) * 2002-10-26 2004-05-13 Johnson Lianw M. Medical appliance delivery apparatus and method of use
US6745445B2 (en) 2002-10-29 2004-06-08 Bard Peripheral Vascular, Inc. Stent compression method
US7959671B2 (en) * 2002-11-05 2011-06-14 Merit Medical Systems, Inc. Differential covering and coating methods
US7875068B2 (en) 2002-11-05 2011-01-25 Merit Medical Systems, Inc. Removable biliary stent
US7637942B2 (en) * 2002-11-05 2009-12-29 Merit Medical Systems, Inc. Coated stent with geometry determinated functionality and method of making the same
US7527644B2 (en) * 2002-11-05 2009-05-05 Alveolus Inc. Stent with geometry determinated functionality and method of making the same
EP1567087B1 (en) 2002-11-08 2009-04-01 Jacques Seguin Endoprosthesis for vascular bifurcation
AU2003290881A1 (en) * 2002-11-15 2004-06-15 Gmp Cardiac Care, Inc. Rail stent
US7294214B2 (en) * 2003-01-08 2007-11-13 Scimed Life Systems, Inc. Medical devices
US20040143317A1 (en) * 2003-01-17 2004-07-22 Stinson Jonathan S. Medical devices
AU2004208554B2 (en) * 2003-01-28 2008-11-06 Gambro Lundia Ab An apparatus and method for monitoring a vascular access of a patient
US7179286B2 (en) * 2003-02-21 2007-02-20 Boston Scientific Scimed, Inc. Stent with stepped connectors
US7367989B2 (en) * 2003-02-27 2008-05-06 Scimed Life Systems, Inc. Rotating balloon expandable sheath bifurcation delivery
US7314480B2 (en) * 2003-02-27 2008-01-01 Boston Scientific Scimed, Inc. Rotating balloon expandable sheath bifurcation delivery
US7001369B2 (en) * 2003-03-27 2006-02-21 Scimed Life Systems, Inc. Medical device
ATE526038T1 (en) * 2003-03-28 2011-10-15 Innovational Holdings Llc IMPLANTABLE MEDICAL DEVICE WITH CONTINUOUS MEDIUM CONCENTRATION DISTANCE
US7637934B2 (en) 2003-03-31 2009-12-29 Merit Medical Systems, Inc. Medical appliance optical delivery and deployment apparatus and method
US7604660B2 (en) * 2003-05-01 2009-10-20 Merit Medical Systems, Inc. Bifurcated medical appliance delivery apparatus and method
CN101005812A (en) 2003-05-07 2007-07-25 先进生物假体表面有限公司 Metallic implantable grafts and method of making same
US6846323B2 (en) 2003-05-15 2005-01-25 Advanced Cardiovascular Systems, Inc. Intravascular stent
DE10325128A1 (en) 2003-06-04 2005-01-05 Qualimed Innovative Medizin-Produkte Gmbh stent
US7169179B2 (en) * 2003-06-05 2007-01-30 Conor Medsystems, Inc. Drug delivery device and method for bi-directional drug delivery
US7241308B2 (en) * 2003-06-09 2007-07-10 Xtent, Inc. Stent deployment systems and methods
WO2004112710A2 (en) 2003-06-17 2004-12-29 Millennium Pharmaceuticals, Inc. COMPOSITIONS AND METHODS FOR INHIBITING TGF-ß
US9155639B2 (en) 2009-04-22 2015-10-13 Medinol Ltd. Helical hybrid stent
US9039755B2 (en) 2003-06-27 2015-05-26 Medinol Ltd. Helical hybrid stent
US8784472B2 (en) * 2003-08-15 2014-07-22 Boston Scientific Scimed, Inc. Clutch driven stent delivery system
US8298280B2 (en) * 2003-08-21 2012-10-30 Boston Scientific Scimed, Inc. Stent with protruding branch portion for bifurcated vessels
US7785653B2 (en) * 2003-09-22 2010-08-31 Innovational Holdings Llc Method and apparatus for loading a beneficial agent into an expandable medical device
US7198675B2 (en) 2003-09-30 2007-04-03 Advanced Cardiovascular Systems Stent mandrel fixture and method for selectively coating surfaces of a stent
US20050080475A1 (en) * 2003-10-14 2005-04-14 Xtent, Inc. A Delaware Corporation Stent delivery devices and methods
US7553324B2 (en) * 2003-10-14 2009-06-30 Xtent, Inc. Fixed stent delivery devices and methods
US7192440B2 (en) * 2003-10-15 2007-03-20 Xtent, Inc. Implantable stent delivery devices and methods
US7175654B2 (en) * 2003-10-16 2007-02-13 Cordis Corporation Stent design having stent segments which uncouple upon deployment
US7189255B2 (en) * 2003-10-28 2007-03-13 Cordis Corporation Prosthesis support ring assembly
US7316711B2 (en) 2003-10-29 2008-01-08 Medtronic Vascular, Inc. Intralumenal stent device for use in body lumens of various diameters
US7344557B2 (en) * 2003-11-12 2008-03-18 Advanced Stent Technologies, Inc. Catheter balloon systems and methods
US7403966B2 (en) * 2003-12-08 2008-07-22 Freescale Semiconductor, Inc. Hardware for performing an arithmetic function
US7258697B1 (en) 2003-12-22 2007-08-21 Advanced Cardiovascular Systems, Inc. Stent with anchors to prevent vulnerable plaque rupture during deployment
US7326236B2 (en) 2003-12-23 2008-02-05 Xtent, Inc. Devices and methods for controlling and indicating the length of an interventional element
US20070156225A1 (en) * 2003-12-23 2007-07-05 Xtent, Inc. Automated control mechanisms and methods for custom length stent apparatus
US7686841B2 (en) * 2003-12-29 2010-03-30 Boston Scientific Scimed, Inc. Rotating balloon expandable sheath bifurcation delivery system
US7922753B2 (en) * 2004-01-13 2011-04-12 Boston Scientific Scimed, Inc. Bifurcated stent delivery system
US7803178B2 (en) 2004-01-30 2010-09-28 Trivascular, Inc. Inflatable porous implants and methods for drug delivery
US20050182474A1 (en) * 2004-02-13 2005-08-18 Medtronic Vascular, Inc. Coated stent having protruding crowns and elongated struts
US8012192B2 (en) * 2004-02-18 2011-09-06 Boston Scientific Scimed, Inc. Multi-stent delivery system
US7225518B2 (en) * 2004-02-23 2007-06-05 Boston Scientific Scimed, Inc. Apparatus for crimping a stent assembly
US7922740B2 (en) 2004-02-24 2011-04-12 Boston Scientific Scimed, Inc. Rotatable catheter assembly
US7744619B2 (en) * 2004-02-24 2010-06-29 Boston Scientific Scimed, Inc. Rotatable catheter assembly
US20050214339A1 (en) 2004-03-29 2005-09-29 Yiwen Tang Biologically degradable compositions for medical applications
US7323006B2 (en) 2004-03-30 2008-01-29 Xtent, Inc. Rapid exchange interventional devices and methods
US20050222671A1 (en) * 2004-03-31 2005-10-06 Schaeffer Darin G Partially biodegradable stent
US7578840B2 (en) * 2004-03-31 2009-08-25 Cook Incorporated Stent with reduced profile
US20050228477A1 (en) * 2004-04-09 2005-10-13 Xtent, Inc. Topographic coatings and coating methods for medical devices
US20050261757A1 (en) 2004-05-21 2005-11-24 Conor Medsystems, Inc. Stent with contoured bridging element
US20060020329A1 (en) * 2004-05-26 2006-01-26 Medtronic Vascular, Inc. Semi-directional drug delivering stents
US20050273149A1 (en) * 2004-06-08 2005-12-08 Tran Thomas T Bifurcated stent delivery system
US8568469B1 (en) 2004-06-28 2013-10-29 Advanced Cardiovascular Systems, Inc. Stent locking element and a method of securing a stent on a delivery system
US20050288766A1 (en) * 2004-06-28 2005-12-29 Xtent, Inc. Devices and methods for controlling expandable prostheses during deployment
US8317859B2 (en) 2004-06-28 2012-11-27 J.W. Medical Systems Ltd. Devices and methods for controlling expandable prostheses during deployment
US8241554B1 (en) 2004-06-29 2012-08-14 Advanced Cardiovascular Systems, Inc. Method of forming a stent pattern on a tube
US20080132999A1 (en) * 2004-07-09 2008-06-05 Mericle Robert A Tubular Polymer Stent Coverings
US7763065B2 (en) * 2004-07-21 2010-07-27 Reva Medical, Inc. Balloon expandable crush-recoverable stent device
US8048145B2 (en) 2004-07-22 2011-11-01 Endologix, Inc. Graft systems having filling structures supported by scaffolds and methods for their use
US8778256B1 (en) 2004-09-30 2014-07-15 Advanced Cardiovascular Systems, Inc. Deformation of a polymer tube in the fabrication of a medical article
US8747878B2 (en) 2006-04-28 2014-06-10 Advanced Cardiovascular Systems, Inc. Method of fabricating an implantable medical device by controlling crystalline structure
US8747879B2 (en) 2006-04-28 2014-06-10 Advanced Cardiovascular Systems, Inc. Method of fabricating an implantable medical device to reduce chance of late inflammatory response
US7971333B2 (en) 2006-05-30 2011-07-05 Advanced Cardiovascular Systems, Inc. Manufacturing process for polymetric stents
US7731890B2 (en) 2006-06-15 2010-06-08 Advanced Cardiovascular Systems, Inc. Methods of fabricating stents with enhanced fracture toughness
US9283099B2 (en) 2004-08-25 2016-03-15 Advanced Cardiovascular Systems, Inc. Stent-catheter assembly with a releasable connection for stent retention
US7229471B2 (en) 2004-09-10 2007-06-12 Advanced Cardiovascular Systems, Inc. Compositions containing fast-leaching plasticizers for improved performance of medical devices
US20060069424A1 (en) * 2004-09-27 2006-03-30 Xtent, Inc. Self-constrained segmented stents and methods for their deployment
US7887579B2 (en) * 2004-09-29 2011-02-15 Merit Medical Systems, Inc. Active stent
US8043553B1 (en) 2004-09-30 2011-10-25 Advanced Cardiovascular Systems, Inc. Controlled deformation of a polymer tube with a restraining surface in fabricating a medical article
US7875233B2 (en) 2004-09-30 2011-01-25 Advanced Cardiovascular Systems, Inc. Method of fabricating a biaxially oriented implantable medical device
US8173062B1 (en) 2004-09-30 2012-05-08 Advanced Cardiovascular Systems, Inc. Controlled deformation of a polymer tube in fabricating a medical article
US20060116602A1 (en) * 2004-12-01 2006-06-01 Alden Dana A Medical sensing device and system
US8292944B2 (en) 2004-12-17 2012-10-23 Reva Medical, Inc. Slide-and-lock stent
US7540995B2 (en) 2005-03-03 2009-06-02 Icon Medical Corp. Process for forming an improved metal alloy stent
WO2006096251A2 (en) * 2005-03-03 2006-09-14 Icon Medical Corp. Improved metal alloys for medical device
US8323333B2 (en) * 2005-03-03 2012-12-04 Icon Medical Corp. Fragile structure protective coating
US20060201601A1 (en) * 2005-03-03 2006-09-14 Icon Interventional Systems, Inc. Flexible markers
US9107899B2 (en) 2005-03-03 2015-08-18 Icon Medical Corporation Metal alloys for medical devices
US20060264914A1 (en) * 2005-03-03 2006-11-23 Icon Medical Corp. Metal alloys for medical devices
WO2006110197A2 (en) * 2005-03-03 2006-10-19 Icon Medical Corp. Polymer biodegradable medical device
DE102005013221A1 (en) * 2005-03-17 2006-09-21 Biotronik Vi Patent Ag System for the treatment of extensive obliterating diseases of a vessel
US7402168B2 (en) * 2005-04-11 2008-07-22 Xtent, Inc. Custom-length stent delivery system with independently operable expansion elements
US7381048B2 (en) 2005-04-12 2008-06-03 Advanced Cardiovascular Systems, Inc. Stents with profiles for gripping a balloon catheter and molds for fabricating stents
US7763198B2 (en) 2005-04-12 2010-07-27 Abbott Cardiovascular Systems Inc. Method for retaining a vascular stent on a catheter
US7947207B2 (en) 2005-04-12 2011-05-24 Abbott Cardiovascular Systems Inc. Method for retaining a vascular stent on a catheter
US8628565B2 (en) * 2005-04-13 2014-01-14 Abbott Cardiovascular Systems Inc. Intravascular stent
US20060248698A1 (en) * 2005-05-05 2006-11-09 Hanson Brian J Tubular stent and methods of making the same
US7731654B2 (en) * 2005-05-13 2010-06-08 Merit Medical Systems, Inc. Delivery device with viewing window and associated method
US7938851B2 (en) * 2005-06-08 2011-05-10 Xtent, Inc. Devices and methods for operating and controlling interventional apparatus
US20060282149A1 (en) * 2005-06-08 2006-12-14 Xtent, Inc., A Delaware Corporation Apparatus and methods for deployment of multiple custom-length prostheses (II)
US8273117B2 (en) * 2005-06-22 2012-09-25 Integran Technologies Inc. Low texture, quasi-isotropic metallic stent
JP2009500121A (en) * 2005-07-07 2009-01-08 ネリックス・インコーポレーテッド System and method for treatment of an intraluminal aneurysm
WO2007014088A2 (en) * 2005-07-25 2007-02-01 Cook Incorporated Intraluminal prosthesis and stent
US7658880B2 (en) 2005-07-29 2010-02-09 Advanced Cardiovascular Systems, Inc. Polymeric stent polishing method and apparatus
US9149378B2 (en) 2005-08-02 2015-10-06 Reva Medical, Inc. Axially nested slide and lock expandable device
US7914574B2 (en) * 2005-08-02 2011-03-29 Reva Medical, Inc. Axially nested slide and lock expandable device
US20070031611A1 (en) * 2005-08-04 2007-02-08 Babaev Eilaz P Ultrasound medical stent coating method and device
US9101949B2 (en) * 2005-08-04 2015-08-11 Eilaz Babaev Ultrasonic atomization and/or seperation system
US7896539B2 (en) * 2005-08-16 2011-03-01 Bacoustics, Llc Ultrasound apparatus and methods for mixing liquids and coating stents
US9248034B2 (en) 2005-08-23 2016-02-02 Advanced Cardiovascular Systems, Inc. Controlled disintegrating implantable medical devices
US20070061001A1 (en) * 2005-09-13 2007-03-15 Advanced Cardiovascular Systems, Inc. Packaging sheath for drug coated stent
WO2007040249A1 (en) 2005-10-06 2007-04-12 Kaneka Corporation Stent to be placed in the living body
US7867547B2 (en) 2005-12-19 2011-01-11 Advanced Cardiovascular Systems, Inc. Selectively coating luminal surfaces of stents
US20070150041A1 (en) * 2005-12-22 2007-06-28 Nellix, Inc. Methods and systems for aneurysm treatment using filling structures
US20070156230A1 (en) 2006-01-04 2007-07-05 Dugan Stephen R Stents with radiopaque markers
US7951185B1 (en) 2006-01-06 2011-05-31 Advanced Cardiovascular Systems, Inc. Delivery of a stent at an elevated temperature
US20070179587A1 (en) * 2006-01-30 2007-08-02 Xtent, Inc. Apparatus and methods for deployment of custom-length prostheses
CN101378714A (en) * 2006-02-01 2009-03-04 宝洁公司 Absorbent article with urine-permeable coversheet
US8821561B2 (en) * 2006-02-22 2014-09-02 Boston Scientific Scimed, Inc. Marker arrangement for bifurcation catheter
US8828077B2 (en) * 2006-03-15 2014-09-09 Medinol Ltd. Flat process of preparing drug eluting stents
US20070219618A1 (en) * 2006-03-17 2007-09-20 Cully Edward H Endoprosthesis having multiple helically wound flexible framework elements
CA2646885A1 (en) 2006-03-20 2007-09-27 Xtent, Inc. Apparatus and methods for deployment of linked prosthetic segments
US20070233233A1 (en) * 2006-03-31 2007-10-04 Boston Scientific Scimed, Inc Tethered expansion columns for controlled stent expansion
US7964210B2 (en) 2006-03-31 2011-06-21 Abbott Cardiovascular Systems Inc. Degradable polymeric implantable medical devices with a continuous phase and discrete phase
US8003156B2 (en) 2006-05-04 2011-08-23 Advanced Cardiovascular Systems, Inc. Rotatable support elements for stents
GB0609841D0 (en) 2006-05-17 2006-06-28 Angiomed Ag Bend-capable tubular prosthesis
US7761968B2 (en) 2006-05-25 2010-07-27 Advanced Cardiovascular Systems, Inc. Method of crimping a polymeric stent
US20070276465A1 (en) * 2006-05-25 2007-11-29 Rosaire Mongrain Stent
US20130325104A1 (en) 2006-05-26 2013-12-05 Abbott Cardiovascular Systems Inc. Stents With Radiopaque Markers
US7951194B2 (en) 2006-05-26 2011-05-31 Abbott Cardiovascular Sysetms Inc. Bioabsorbable stent with radiopaque coating
US7959940B2 (en) 2006-05-30 2011-06-14 Advanced Cardiovascular Systems, Inc. Polymer-bioceramic composite implantable medical devices
US7842737B2 (en) 2006-09-29 2010-11-30 Abbott Cardiovascular Systems Inc. Polymer blend-bioceramic composite implantable medical devices
US8343530B2 (en) 2006-05-30 2013-01-01 Abbott Cardiovascular Systems Inc. Polymer-and polymer blend-bioceramic composite implantable medical devices
US8034287B2 (en) 2006-06-01 2011-10-11 Abbott Cardiovascular Systems Inc. Radiation sterilization of medical devices
US8486135B2 (en) 2006-06-01 2013-07-16 Abbott Cardiovascular Systems Inc. Implantable medical devices fabricated from branched polymers
US20070281117A1 (en) * 2006-06-02 2007-12-06 Xtent, Inc. Use of plasma in formation of biodegradable stent coating
BRPI0602378A (en) * 2006-06-06 2008-01-22 Luiz Gonzaga Granja Jr flanged anastomosis prosthesis
US8603530B2 (en) 2006-06-14 2013-12-10 Abbott Cardiovascular Systems Inc. Nanoshell therapy
US8048448B2 (en) 2006-06-15 2011-11-01 Abbott Cardiovascular Systems Inc. Nanoshells for drug delivery
US8535372B1 (en) 2006-06-16 2013-09-17 Abbott Cardiovascular Systems Inc. Bioabsorbable stent with prohealing layer
US8333000B2 (en) 2006-06-19 2012-12-18 Advanced Cardiovascular Systems, Inc. Methods for improving stent retention on a balloon catheter
US8017237B2 (en) 2006-06-23 2011-09-13 Abbott Cardiovascular Systems, Inc. Nanoshells on polymers
US9072820B2 (en) 2006-06-26 2015-07-07 Advanced Cardiovascular Systems, Inc. Polymer composite stent with polymer particles
US8128688B2 (en) 2006-06-27 2012-03-06 Abbott Cardiovascular Systems Inc. Carbon coating on an implantable device
US7794776B1 (en) 2006-06-29 2010-09-14 Abbott Cardiovascular Systems Inc. Modification of polymer stents with radiation
US7740791B2 (en) 2006-06-30 2010-06-22 Advanced Cardiovascular Systems, Inc. Method of fabricating a stent with features by blow molding
US8613698B2 (en) 2006-07-10 2013-12-24 Mcneil-Ppc, Inc. Resilient device
US7717892B2 (en) * 2006-07-10 2010-05-18 Mcneil-Ppc, Inc. Method of treating urinary incontinence
WO2008008794A2 (en) 2006-07-10 2008-01-17 Mc Neil-Ppc, Inc. Resilient device
US10219884B2 (en) 2006-07-10 2019-03-05 First Quality Hygienic, Inc. Resilient device
US10004584B2 (en) 2006-07-10 2018-06-26 First Quality Hygienic, Inc. Resilient intravaginal device
US7823263B2 (en) 2006-07-11 2010-11-02 Abbott Cardiovascular Systems Inc. Method of removing stent islands from a stent
WO2008008291A2 (en) * 2006-07-13 2008-01-17 Icon Medical Corp. Stent
US7757543B2 (en) 2006-07-13 2010-07-20 Advanced Cardiovascular Systems, Inc. Radio frequency identification monitoring of stents
US7998404B2 (en) 2006-07-13 2011-08-16 Advanced Cardiovascular Systems, Inc. Reduced temperature sterilization of stents
US7794495B2 (en) 2006-07-17 2010-09-14 Advanced Cardiovascular Systems, Inc. Controlled degradation of stents
US7886419B2 (en) 2006-07-18 2011-02-15 Advanced Cardiovascular Systems, Inc. Stent crimping apparatus and method
US8016879B2 (en) 2006-08-01 2011-09-13 Abbott Cardiovascular Systems Inc. Drug delivery after biodegradation of the stent scaffolding
US9173733B1 (en) 2006-08-21 2015-11-03 Abbott Cardiovascular Systems Inc. Tracheobronchial implantable medical device and methods of use
US7988720B2 (en) 2006-09-12 2011-08-02 Boston Scientific Scimed, Inc. Longitudinally flexible expandable stent
US7923022B2 (en) 2006-09-13 2011-04-12 Advanced Cardiovascular Systems, Inc. Degradable polymeric implantable medical devices with continuous phase and discrete phase
MX344492B (en) 2006-10-22 2016-12-16 Idev Tech Inc * Devices and methods for stent advancement.
EP3034046B1 (en) 2006-10-22 2018-01-17 IDEV Technologies, INC. Methods for securing strand ends and the resulting devices
US20080269774A1 (en) * 2006-10-26 2008-10-30 Chestnut Medical Technologies, Inc. Intracorporeal Grasping Device
GB0622465D0 (en) * 2006-11-10 2006-12-20 Angiomed Ag Stent
US8099849B2 (en) 2006-12-13 2012-01-24 Abbott Cardiovascular Systems Inc. Optimizing fracture toughness of polymeric stent
US20080142616A1 (en) * 2006-12-15 2008-06-19 Bacoustics Llc Method of Producing a Directed Spray
US7704275B2 (en) 2007-01-26 2010-04-27 Reva Medical, Inc. Circumferentially nested expandable device
WO2008100852A2 (en) 2007-02-13 2008-08-21 Abbott Cardiovascular Systems Inc. Mri compatible, radiopaque alloys for use in medical devices
US20080199510A1 (en) 2007-02-20 2008-08-21 Xtent, Inc. Thermo-mechanically controlled implants and methods of use
JP4961517B2 (en) * 2007-02-20 2012-06-27 国立大学法人福井大学 Stent and therapeutic device for tubular organ using the same
US8486132B2 (en) 2007-03-22 2013-07-16 J.W. Medical Systems Ltd. Devices and methods for controlling expandable prostheses during deployment
US8262723B2 (en) 2007-04-09 2012-09-11 Abbott Cardiovascular Systems Inc. Implantable medical devices fabricated from polymer blends with star-block copolymers
US7829008B2 (en) 2007-05-30 2010-11-09 Abbott Cardiovascular Systems Inc. Fabricating a stent from a blow molded tube
US9149610B2 (en) 2007-05-31 2015-10-06 Abbott Cardiovascular Systems Inc. Method and apparatus for improving delivery of an agent to a kidney
US9144509B2 (en) 2007-05-31 2015-09-29 Abbott Cardiovascular Systems Inc. Method and apparatus for delivering an agent to a kidney
US8216209B2 (en) 2007-05-31 2012-07-10 Abbott Cardiovascular Systems Inc. Method and apparatus for delivering an agent to a kidney
US9364586B2 (en) 2007-05-31 2016-06-14 Abbott Cardiovascular Systems Inc. Method and apparatus for improving delivery of an agent to a kidney
US7959857B2 (en) 2007-06-01 2011-06-14 Abbott Cardiovascular Systems Inc. Radiation sterilization of medical devices
US8293260B2 (en) 2007-06-05 2012-10-23 Abbott Cardiovascular Systems Inc. Elastomeric copolymer coatings containing poly (tetramethyl carbonate) for implantable medical devices
US8202528B2 (en) 2007-06-05 2012-06-19 Abbott Cardiovascular Systems Inc. Implantable medical devices with elastomeric block copolymer coatings
US8425591B1 (en) 2007-06-11 2013-04-23 Abbott Cardiovascular Systems Inc. Methods of forming polymer-bioceramic composite medical devices with bioceramic particles
US8048441B2 (en) 2007-06-25 2011-11-01 Abbott Cardiovascular Systems, Inc. Nanobead releasing medical devices
JP5734650B2 (en) * 2007-06-25 2015-06-17 マイクロベンション インコーポレイテッド Self-expanding prosthesis
US7901452B2 (en) 2007-06-27 2011-03-08 Abbott Cardiovascular Systems Inc. Method to fabricate a stent having selected morphology to reduce restenosis
US7955381B1 (en) 2007-06-29 2011-06-07 Advanced Cardiovascular Systems, Inc. Polymer-bioceramic composite implantable medical device with different types of bioceramic particles
US7753285B2 (en) 2007-07-13 2010-07-13 Bacoustics, Llc Echoing ultrasound atomization and/or mixing system
US7780095B2 (en) 2007-07-13 2010-08-24 Bacoustics, Llc Ultrasound pumping apparatus
US8486134B2 (en) 2007-08-01 2013-07-16 Boston Scientific Scimed, Inc. Bifurcation treatment system and methods
US20090076584A1 (en) * 2007-09-19 2009-03-19 Xtent, Inc. Apparatus and methods for deployment of multiple custom-length prostheses
US20090082845A1 (en) * 2007-09-26 2009-03-26 Boston Scientific Corporation Alignment stent apparatus and method
US8663309B2 (en) 2007-09-26 2014-03-04 Trivascular, Inc. Asymmetric stent apparatus and method
US8226701B2 (en) 2007-09-26 2012-07-24 Trivascular, Inc. Stent and delivery system for deployment thereof
US8066755B2 (en) 2007-09-26 2011-11-29 Trivascular, Inc. System and method of pivoted stent deployment
EP2194921B1 (en) 2007-10-04 2018-08-29 TriVascular, Inc. Modular vascular graft for low profile percutaneous delivery
US11337714B2 (en) 2007-10-17 2022-05-24 Covidien Lp Restoring blood flow and clot removal during acute ischemic stroke
US8088140B2 (en) 2008-05-19 2012-01-03 Mindframe, Inc. Blood flow restorative and embolus removal methods
WO2009055615A1 (en) * 2007-10-23 2009-04-30 Endologix, Inc. Stent
US8083789B2 (en) 2007-11-16 2011-12-27 Trivascular, Inc. Securement assembly and method for expandable endovascular device
US8328861B2 (en) 2007-11-16 2012-12-11 Trivascular, Inc. Delivery system and method for bifurcated graft
JP5216098B2 (en) 2007-11-30 2013-06-19 レヴァ メディカル、 インコーポレイテッド Axial and radially nested expandable device
US8157751B2 (en) * 2007-12-13 2012-04-17 Boston Scientific Scimed, Inc. Coil member for a medical device
US7722661B2 (en) * 2007-12-19 2010-05-25 Boston Scientific Scimed, Inc. Stent
WO2009088953A2 (en) * 2007-12-31 2009-07-16 Boston Scientific Scimed Inc. Bifurcation stent delivery system and methods
US8193182B2 (en) 2008-01-04 2012-06-05 Intellikine, Inc. Substituted isoquinolin-1(2H)-ones, and methods of use thereof
KR101660050B1 (en) 2008-01-04 2016-09-26 인텔리카인, 엘엘씨 Certain chemical entities, compositions and methods
ES2647310T3 (en) 2008-02-22 2017-12-20 Covidien Lp Device for flow restoration
US8196279B2 (en) * 2008-02-27 2012-06-12 C. R. Bard, Inc. Stent-graft covering process
US9101503B2 (en) 2008-03-06 2015-08-11 J.W. Medical Systems Ltd. Apparatus having variable strut length and methods of use
EP2259736B1 (en) 2008-03-14 2012-04-25 Synthes GmbH Nested expandable sleeve implant
EP2252293B1 (en) 2008-03-14 2018-06-27 Intellikine, LLC Kinase inhibitors and methods of use
AU2009240419A1 (en) 2008-04-25 2009-10-29 Nellix, Inc. Stent graft delivery system
US8333003B2 (en) * 2008-05-19 2012-12-18 Boston Scientific Scimed, Inc. Bifurcation stent crimping systems and methods
US8377108B2 (en) 2008-06-02 2013-02-19 Boston Scientific Scimed, Inc. Staggered two balloon bifurcation catheter assembly and methods
JP2011522615A (en) * 2008-06-04 2011-08-04 ネリックス・インコーポレーテッド Sealing device and method of use
WO2009149410A1 (en) * 2008-06-05 2009-12-10 Boston Scientific Scimed, Inc. Deflatable bifurcated device
EP2299945B1 (en) * 2008-06-05 2016-03-23 Boston Scientific Scimed, Inc. Balloon bifurcated lumen treatment
NZ590258A (en) 2008-07-08 2013-10-25 Intellikine Llc Kinase inhibitors and methods of use
US20100049307A1 (en) * 2008-08-25 2010-02-25 Aga Medical Corporation Stent graft having extended landing area and method for using the same
US8133199B2 (en) 2008-08-27 2012-03-13 Boston Scientific Scimed, Inc. Electroactive polymer activation system for a medical device
US8821562B2 (en) 2008-09-25 2014-09-02 Advanced Bifurcation Systems, Inc. Partially crimped stent
AU2009296415B2 (en) 2008-09-25 2015-11-19 Advanced Bifurcation Systems Inc. Partially crimped stent
US8828071B2 (en) 2008-09-25 2014-09-09 Advanced Bifurcation Systems, Inc. Methods and systems for ostial stenting of a bifurcation
US11298252B2 (en) 2008-09-25 2022-04-12 Advanced Bifurcation Systems Inc. Stent alignment during treatment of a bifurcation
EP2331014B1 (en) 2008-10-10 2017-08-09 Reva Medical, Inc. Expandable slide and lock stent
US8476282B2 (en) 2008-11-03 2013-07-02 Intellikine Llc Benzoxazole kinase inhibitors and methods of use
US8764813B2 (en) 2008-12-23 2014-07-01 Cook Medical Technologies Llc Gradually self-expanding stent
WO2010091093A1 (en) 2009-02-03 2010-08-12 Abbott Cardiovascular Systems Inc. Improved laser cutting process for forming stents
WO2010091100A1 (en) 2009-02-03 2010-08-12 Abbott Cardiovascular Systems Inc. Multiple beam laser system for forming stents
WO2010091106A1 (en) 2009-02-03 2010-08-12 Abbott Cardiovascular Systems Inc. Improved laser cutting system
EP2403438B1 (en) * 2009-03-04 2021-04-21 Peytant Solutions, Inc. Stents modified with material comprising amnion tissue and corresponding processes
US20100228337A1 (en) * 2009-03-04 2010-09-09 Abbott Laboratories Vascular Enterprises Limited Mirror image stent and method of use
WO2010129816A2 (en) 2009-05-07 2010-11-11 Intellikine, Inc. Heterocyclic compounds and uses thereof
IN2012DN01961A (en) 2009-08-17 2015-08-21 Intellikine Llc
US9649211B2 (en) 2009-11-04 2017-05-16 Confluent Medical Technologies, Inc. Alternating circumferential bridge stent design and methods for use thereof
US10092427B2 (en) 2009-11-04 2018-10-09 Confluent Medical Technologies, Inc. Alternating circumferential bridge stent design and methods for use thereof
US20110152604A1 (en) * 2009-12-23 2011-06-23 Hull Jr Raymond J Intravaginal incontinence device
US20110276078A1 (en) 2009-12-30 2011-11-10 Nellix, Inc. Filling structure for a graft system and methods of use
US8568471B2 (en) 2010-01-30 2013-10-29 Abbott Cardiovascular Systems Inc. Crush recoverable polymer scaffolds
US8808353B2 (en) 2010-01-30 2014-08-19 Abbott Cardiovascular Systems Inc. Crush recoverable polymer scaffolds having a low crossing profile
US8398916B2 (en) 2010-03-04 2013-03-19 Icon Medical Corp. Method for forming a tubular medical device
CN103037815B (en) 2010-03-24 2015-05-13 高级分支系统股份有限公司 Methods and systems for treating a bifurcation with provisional side branch stenting
AU2011232361B2 (en) 2010-03-24 2015-05-28 Advanced Bifurcation Systems Inc. Stent alignment during treatment of a bifurcation
WO2011119884A1 (en) 2010-03-24 2011-09-29 Advanced Bifurcation Systems, Inc System and methods for treating a bifurcation
US8632582B2 (en) 2010-03-25 2014-01-21 Mayo Foundation For Medical Education And Research Removable and/or retrievable stents and kits
WO2011127452A1 (en) 2010-04-10 2011-10-13 Reva Medical, Inc Expandable slide and lock stent
CN103002738A (en) 2010-05-21 2013-03-27 英特利凯恩有限责任公司 Chemical compounds, compositions and methods for kinase modulation
US9023095B2 (en) 2010-05-27 2015-05-05 Idev Technologies, Inc. Stent delivery system with pusher assembly
US9301864B2 (en) 2010-06-08 2016-04-05 Veniti, Inc. Bi-directional stent delivery system
US8864811B2 (en) 2010-06-08 2014-10-21 Veniti, Inc. Bi-directional stent delivery system
EP2611397B1 (en) 2010-08-30 2022-06-29 Celonova Biosciences, Inc. Expandable devices
US8556511B2 (en) 2010-09-08 2013-10-15 Abbott Cardiovascular Systems, Inc. Fluid bearing to support stent tubing during laser cutting
US9233014B2 (en) 2010-09-24 2016-01-12 Veniti, Inc. Stent with support braces
US9039749B2 (en) 2010-10-01 2015-05-26 Covidien Lp Methods and apparatuses for flow restoration and implanting members in the human body
EP2637669A4 (en) 2010-11-10 2014-04-02 Infinity Pharmaceuticals Inc Heterocyclic compounds and uses thereof
EP2658484A1 (en) 2010-12-30 2013-11-06 Boston Scientific Scimed, Inc. Multi stage opening stent designs
MX347708B (en) 2011-01-10 2017-05-09 Infinity Pharmaceuticals Inc Processes for preparing isoquinolinones and solid forms of isoquinolinones.
US8801768B2 (en) 2011-01-21 2014-08-12 Endologix, Inc. Graft systems having semi-permeable filling structures and methods for their use
EP2672932B1 (en) 2011-02-08 2018-09-19 Advanced Bifurcation Systems, Inc. System for treating a bifurcation with a fully crimped stent
CA2826760A1 (en) 2011-02-08 2012-08-16 Advanced Bifurcation Systems, Inc. Multi-stent and multi-balloon apparatus for treating bifurcations and methods of use
WO2012116237A2 (en) 2011-02-23 2012-08-30 Intellikine, Llc Heterocyclic compounds and uses thereof
CN103391757B (en) 2011-03-03 2016-01-20 波士顿科学国际有限公司 Low strain dynamic high strength support
US8790388B2 (en) 2011-03-03 2014-07-29 Boston Scientific Scimed, Inc. Stent with reduced profile
EP2693980B1 (en) 2011-04-06 2022-07-13 Endologix LLC System for endovascular aneurysm treatment
US8728563B2 (en) 2011-05-03 2014-05-20 Palmaz Scientific, Inc. Endoluminal implantable surfaces, stents, and grafts and method of making same
US11045297B2 (en) 2012-10-18 2021-06-29 Vactronix Scientific Llc Topographical features and patterns on a surface of a medical device and methods of making the same
US9050394B2 (en) 2011-05-09 2015-06-09 Palmaz Scientific, Inc. Method for making topographical features on a surface of a medical device
FR2976478B1 (en) 2011-06-17 2013-07-05 Newco DEVICE FOR DELIVERING STENT IN A BLOOD OR SIMILAR VESSEL.
US20130005218A1 (en) * 2011-06-30 2013-01-03 Abbott Cardiovascular Systems Inc. Apparatus and method for formation of foil-shaped stent struts
US8726483B2 (en) 2011-07-29 2014-05-20 Abbott Cardiovascular Systems Inc. Methods for uniform crimping and deployment of a polymer scaffold
WO2013078440A2 (en) 2011-11-23 2013-05-30 Intellikine, Llc Enhanced treatment regimens using mtor inhibitors
US8992595B2 (en) 2012-04-04 2015-03-31 Trivascular, Inc. Durable stent graft with tapered struts and stable delivery methods and devices
US9254212B2 (en) * 2012-04-06 2016-02-09 Abbott Cardiovascular Systems Inc. Segmented scaffolds and delivery thereof for peripheral applications
US9498363B2 (en) 2012-04-06 2016-11-22 Trivascular, Inc. Delivery catheter for endovascular device
NZ716708A (en) 2012-05-14 2016-08-26 Bard Inc C R Uniformly expandable stent
US20140120060A1 (en) 2012-11-01 2014-05-01 Infinity Pharmaceuticals, Inc. Treatment of rheumatoid arthritis and asthma using pi3 kinase inhibitors
DE102012220129B4 (en) 2012-11-05 2022-12-15 Optimed Medizinische Lnstrumente Gmbh stent
US9566633B2 (en) 2012-11-15 2017-02-14 Vactronix Scientific, Inc. Stents having a hybrid pattern and methods of manufacture
USD723165S1 (en) 2013-03-12 2015-02-24 C. R. Bard, Inc. Stent
JP6533776B2 (en) 2013-03-14 2019-06-19 エンドーロジックス インコーポレイテッド System for treating an aneurysm in a patient's body and method of operating the same
CA2905515C (en) 2013-03-14 2020-11-10 Palmaz Scientific, Inc. Monolithic medical devices, methods of making and using the same
US9408732B2 (en) 2013-03-14 2016-08-09 Reva Medical, Inc. Reduced-profile slide and lock stent
EP2968340A4 (en) 2013-03-15 2016-08-10 Intellikine Llc Combination of kinase inhibitors and uses thereof
US10227370B2 (en) 2013-08-02 2019-03-12 California Institute Of Technology Heparan sulfate/heparin mimetics with anti-chemokine and anti-inflammatory activity
US9770461B2 (en) 2013-08-02 2017-09-26 California Institute Of Technology Tailored glycopolymers as anticoagulant heparin mimetics
US10076399B2 (en) 2013-09-13 2018-09-18 Covidien Lp Endovascular device engagement
US9433763B2 (en) 2013-09-27 2016-09-06 Acclarent, Inc. Sinus wall implant
JP6427197B2 (en) 2013-10-03 2018-11-21 クラ オンコロジー, インコーポレイテッド Inhibitors of ERK and methods of use
USD888245S1 (en) 2014-03-14 2020-06-23 Vactronix Scientific, Llc Stent device
US9901706B2 (en) 2014-04-11 2018-02-27 Boston Scientific Scimed, Inc. Catheters and catheter shafts
US10022172B2 (en) 2014-06-25 2018-07-17 Spine Wave, Inc. Minimally invasive posterolateral fusion
US9999527B2 (en) 2015-02-11 2018-06-19 Abbott Cardiovascular Systems Inc. Scaffolds having radiopaque markers
US9839539B2 (en) 2015-03-05 2017-12-12 Cook Medical Technologies Llc Bow stent
WO2016168176A1 (en) 2015-04-13 2016-10-20 Cook Medical Technologies Llc Axial lock and release stent deployment system
US9700443B2 (en) 2015-06-12 2017-07-11 Abbott Cardiovascular Systems Inc. Methods for attaching a radiopaque marker to a scaffold
US9775723B2 (en) 2015-06-16 2017-10-03 Spine Wave, Inc. Instrument and system for placing graft, implant and graft material for minimally invasive posterolateral fusion
WO2017083488A1 (en) 2015-11-11 2017-05-18 Warner Babcock Institute for Green Chemistry Benzofuran derivatives for the treatment of cns and other disorders
US11351048B2 (en) 2015-11-16 2022-06-07 Boston Scientific Scimed, Inc. Stent delivery systems with a reinforced deployment sheath
US10130465B2 (en) 2016-02-23 2018-11-20 Abbott Cardiovascular Systems Inc. Bifurcated tubular graft for treating tricuspid regurgitation
WO2017218802A1 (en) 2016-06-15 2017-12-21 Prelude Therapeutics, Incorporated Selective inhibitors of protein arginine methyltransferase 5 (prmt5)
US11020253B2 (en) 2016-06-23 2021-06-01 M.I. Tech Co., Ltd. Multi-hole stent for digestive organs
WO2018075601A1 (en) 2016-10-18 2018-04-26 Prelude Therapeutics, Incorporated Selective inhibitors of protein arginine methyltransferase 5 (prmt5)
WO2018085818A1 (en) 2016-11-07 2018-05-11 Prelude Therapeutics, Incorporated Selective inhibitors of protein arginine methyltransferase 5 (prmt5)
WO2018085833A2 (en) 2016-11-07 2018-05-11 Prelude Therapeutics, Incorporated Selective inhibitors of protein arginine methyl transferase 5 (prmt5)
WO2018152501A1 (en) 2017-02-20 2018-08-23 Prelude Therapeutics, Incorporated Selective inhibitors of protein arginine methyltransferase 5 (prmt5)
US11220524B2 (en) 2017-02-20 2022-01-11 Prelude Therapeutics Incorporated Selective inhibitors of protein arginine methyltransferase 5 (PRMT5)
WO2018160855A1 (en) 2017-03-01 2018-09-07 Prelude Therapeutics, Incorporated Selective inhibitors of protein arginine methyltransferase 5 (prmt5)
WO2018160824A1 (en) 2017-03-01 2018-09-07 Prelude Therapeutics, Incorporated Selective inhibitors of protein arginine methyltransferase 5 (prmt5)
US10940030B2 (en) 2017-03-10 2021-03-09 Serenity Medical, Inc. Method and system for delivering a self-expanding stent to the venous sinuses
PT3665179T (en) 2017-08-09 2021-09-10 Prelude Therapeutics Inc Selective inhibitors of protein arginine methyltransferase 5 (prmt5)
CN111542525B (en) 2017-10-26 2023-06-27 普莱鲁德疗法有限公司 Selective inhibitors of protein arginine methyltransferase 5 (PRMT 5)
US10711007B2 (en) 2018-03-14 2020-07-14 Prelude Therapeutics Incorporated Selective inhibitors of protein arginine methyltransferase 5 (PRMT5)
FI3765461T3 (en) 2018-03-14 2023-11-13 Prelude Therapeutics Inc Selective inhibitors of protein arginine methyltransferase 5 (prmt5)
US10575973B2 (en) 2018-04-11 2020-03-03 Abbott Cardiovascular Systems Inc. Intravascular stent having high fatigue performance
CA3118919A1 (en) 2018-11-09 2020-05-14 Prelude Therapeutics, Incorporated Spiro-sulfonamide derivatives as inhibitors of myeloid cell leukemia-1 (mcl-1) protein
US20220064170A1 (en) 2018-12-14 2022-03-03 Prelude Therapeutics, Incorporated Bicyclic heterocyclic derivatives and their use as pharmaceuticals
MX2021009796A (en) 2019-02-13 2021-09-08 Prelude Therapeutics Inc Selective inhibitor of protein arginine methyltransferase 5 (prmt5).
BR112022004630A2 (en) 2019-09-18 2022-05-31 Prelude Therapeutics Inc Selective protein arginine methyltransferase 5 (prmt5) inhibitors
US20230212191A1 (en) 2020-04-16 2023-07-06 Prelude Therapeutics, Incorporated Spiro-sulfonimidamide derivatives as inhibitors of myeloid cell leukemia-1 (mcl-1) protein
MX2022014219A (en) 2020-05-13 2023-01-16 Prelude Therapeutics Inc Spiro-sulfonamide derivatives as inhibitors of myeloid cell leukemia-1 (mcl-1) protein.
BR112022025061A2 (en) 2020-06-09 2023-01-31 Prelude Therapeutics Inc COMPOUNDS THAT TARGET BRM AND ASSOCIATED METHODS OF USE
CA3196016A1 (en) 2020-09-21 2022-03-24 Prelude Therapeutics, Incorporated Cdk inhibitors and their use as pharmaceuticals
EP4240743A1 (en) 2020-11-06 2023-09-13 Prelude Therapeutics, Incorporated Brm targeting compounds and associated methods of use
US20220267345A1 (en) 2020-12-18 2022-08-25 Prelude Therapeutics, Incorporated CDK Inhibitors And Their Use As Pharmaceuticals
AU2021405620A1 (en) 2020-12-23 2023-06-29 Actelion Pharmaceuticals Ltd Pyrazolothiazole carboxamides and their uses as pdgfr inhibitors
TW202241906A (en) 2020-12-30 2022-11-01 美商泰拉生物科學公司 Indazole compounds
WO2023279041A1 (en) 2021-06-30 2023-01-05 Tyra Biosciences, Inc. Indazole compounds
WO2023287787A1 (en) 2021-07-13 2023-01-19 Prelude Therapeutics, Incorporated Brm targeting compounds and associated methods of use
TW202313053A (en) 2021-07-30 2023-04-01 瑞士商艾克泰聯製藥有限公司 Pyrazolopyrimidines and their uses as pdgfr inhibitors
US20230144528A1 (en) 2021-09-30 2023-05-11 Prelude Therapeutics Incorporated CDK Inhibitors And Their Use As Pharmaceuticals
US20230234964A1 (en) 2022-01-21 2023-07-27 Prelude Therapeutics Incorporated CDK Inhibitors And Their Use As Pharmaceuticals
US20230257394A1 (en) 2022-02-03 2023-08-17 Prelude Therapeutics, Incorporated CDK Inhibitors And Their Use As Pharmaceuticals
WO2023172957A1 (en) 2022-03-09 2023-09-14 Prelude Therapeutics, Incorporated Thaizole-pyrimdiine cdk inhibitors and their use as pharmaceuticals
WO2023178547A1 (en) 2022-03-23 2023-09-28 Prelude Therapeutics, Incorporated Polymorphic compounds and uses thereof
WO2023192416A1 (en) 2022-03-29 2023-10-05 Prelude Therapeutics, Incorporated Mutant pi3k-alpha inhibitors and their use as pharmaceuticals
WO2023220577A1 (en) 2022-05-10 2023-11-16 Prelude Therapeutics, Incorporated 6,6a,7,8,9,10-hexahydro-5h-pyrazino[1',2':4,5]pyrazino[2,3-c]pyridazine derivatives as smarca4 protein degraders for the treatment of cancer
US20230416240A1 (en) 2022-06-16 2023-12-28 Prelude Therapeutics Incorporated Kat6 targeting compounds
WO2023247596A1 (en) 2022-06-22 2023-12-28 Actelion Pharmaceuticals Ltd Pyrazolothiazole carboxamides and their uses as pdgfr inhibitors
WO2023247593A1 (en) 2022-06-22 2023-12-28 Actelion Pharmaceuticals Ltd Pyrrolopyridine carboxamides and their uses as pdgfr inhibitors
WO2023247595A1 (en) 2022-06-22 2023-12-28 Actelion Pharmaceuticals Ltd Pyrazolopyrazine carboxamides and their uses as pdgfr inhibitors
WO2024006897A1 (en) 2022-06-29 2024-01-04 Tyra Biosciences, Inc. Indazole compounds
WO2024006883A1 (en) 2022-06-29 2024-01-04 Tyra Biosciences, Inc. Polymorphic compounds and uses thereof

Citations (80)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US861659A (en) * 1906-10-03 1907-07-30 Edgar F Johnston Flexible shafting.
US3279996A (en) * 1962-08-28 1966-10-18 Jr David M Long Polysiloxane carrier for controlled release of drugs and other agents
US3526004A (en) * 1969-05-19 1970-09-01 Fred Brandenberger Necktie and removable knot
US3526005A (en) * 1967-06-29 1970-09-01 Gulf General Atomic Inc Method of preparing an intravascular defect by implanting a pyrolytic carbon coated prosthesis
US3599641A (en) * 1970-03-13 1971-08-17 David S Sheridan Combination connector and channel closure system for catheters
US3657744A (en) * 1970-05-08 1972-04-25 Univ Minnesota Method for fixing prosthetic implants in a living body
US3744596A (en) * 1971-01-12 1973-07-10 Bromsregulator Svenska Ab Pneumatic cylinder-piston unit for railway brake riggings
US3932627A (en) * 1974-02-04 1976-01-13 Rescue Products, Inc. Siver-heparin-allantoin complex
US3948254A (en) * 1971-11-08 1976-04-06 Alza Corporation Novel drug delivery device
US3952334A (en) * 1974-11-29 1976-04-27 General Atomic Company Biocompatible carbon prosthetic devices
US3968800A (en) * 1974-09-17 1976-07-13 Vilasi Joseph A Device for insertion into a body opening
US4069307A (en) * 1970-10-01 1978-01-17 Alza Corporation Drug-delivery device comprising certain polymeric materials for controlled release of drug
US4076285A (en) * 1975-08-01 1978-02-28 Erika, Inc. Laminar flow connector for conduits
US4292965A (en) * 1978-12-29 1981-10-06 The Population Council, Inc. Intravaginal ring
US4299226A (en) * 1979-08-08 1981-11-10 Banka Vidya S Coronary dilation method
US4300244A (en) * 1979-09-19 1981-11-17 Carbomedics, Inc. Cardiovascular grafts
US4312920A (en) * 1979-11-07 1982-01-26 The United States Of America As Represented By The Department Of Health & Human Services Polymer alloy blood compatible surface
US4321711A (en) * 1978-10-18 1982-03-30 Sumitomo Electric Industries, Ltd. Vascular prosthesis
US4323071A (en) * 1978-04-24 1982-04-06 Advanced Catheter Systems, Inc. Vascular guiding catheter assembly and vascular dilating catheter assembly and a combination thereof and methods of making the same
US4390599A (en) * 1980-07-31 1983-06-28 Raychem Corporation Enhanced recovery memory metal device
US4503569A (en) * 1983-03-03 1985-03-12 Dotter Charles T Transluminally placed expandable graft prosthesis
US4512338A (en) * 1983-01-25 1985-04-23 Balko Alexander B Process for restoring patency to body vessels
US4550447A (en) * 1983-08-03 1985-11-05 Shiley Incorporated Vascular graft prosthesis
US4550569A (en) * 1983-06-10 1985-11-05 Hitachi, Ltd. Main steam inlet structure for steam turbine
US4553545A (en) * 1981-09-16 1985-11-19 Medinvent S.A. Device for application in blood vessels or other difficultly accessible locations and its use
US4560374A (en) * 1983-10-17 1985-12-24 Hammerslag Julius G Method for repairing stenotic vessels
US4562596A (en) * 1984-04-25 1986-01-07 Elliot Kornberg Aortic graft, device and method for performing an intraluminal abdominal aortic aneurysm repair
US4565740A (en) * 1982-02-09 1986-01-21 Ird-Biomaterial Ab Surface modified solid substrate and a method for its preparation
US4580568A (en) * 1984-10-01 1986-04-08 Cook, Incorporated Percutaneous endovascular stent and method for insertion thereof
US4613665A (en) * 1982-02-09 1986-09-23 Olle Larm Process for covalent coupling for the production of conjugates, and polysaccharide containing products thereby obtained
US4642111A (en) * 1982-02-12 1987-02-10 Unitika Ltd. Injector filled with an anti-cancer composition
US4656083A (en) * 1983-08-01 1987-04-07 Washington Research Foundation Plasma gas discharge treatment for improving the biocompatibility of biomaterials
US4655771A (en) * 1982-04-30 1987-04-07 Shepherd Patents S.A. Prosthesis comprising an expansible or contractile tubular body
US4676241A (en) * 1984-01-16 1987-06-30 W.L.G. Technology Ventilation tube swivel
US4678466A (en) * 1981-06-25 1987-07-07 Rosenwald Peter L Internal medication delivery method and vehicle
US4687482A (en) * 1984-04-27 1987-08-18 Scripps Clinic And Research Foundation Vascular prosthesis
US4689046A (en) * 1985-03-11 1987-08-25 Carbomedics, Inc. Heart valve prosthesis
US4731054A (en) * 1985-07-02 1988-03-15 Sulzer Brothers Limited Medical repository probe
US4733665A (en) * 1985-11-07 1988-03-29 Expandable Grafts Partnership Expandable intraluminal graft, and method and apparatus for implanting an expandable intraluminal graft
US4735652A (en) * 1986-11-17 1988-04-05 Gte Products Corporation Process for producing agglomerates of aluminum based material
US4740207A (en) * 1986-09-10 1988-04-26 Kreamer Jeffry W Intralumenal graft
US4753652A (en) * 1984-05-04 1988-06-28 Children's Medical Center Corporation Biomaterial implants which resist calcification
US4753625A (en) * 1985-07-17 1988-06-28 Kabushiki Kaisha Universal Coin pay-out apparatus
US4760849A (en) * 1985-04-10 1988-08-02 Medinvent S.A. Planar blank and a coil spring manufactured therefrom
US4768507A (en) * 1986-02-24 1988-09-06 Medinnovations, Inc. Intravascular stent and percutaneous insertion catheter system for the dilation of an arterial stenosis and the prevention of arterial restenosis
US4787899A (en) * 1983-12-09 1988-11-29 Lazarus Harrison M Intraluminal graft device, system and method
US4800882A (en) * 1987-03-13 1989-01-31 Cook Incorporated Endovascular stent and delivery system
US4856516A (en) * 1989-01-09 1989-08-15 Cordis Corporation Endovascular stent apparatus and method
US4872867A (en) * 1985-06-19 1989-10-10 Ube Industries, Ltd. Compositions having antithrombogenic properties and blood contact medical devices using the same
US4872567A (en) * 1986-05-23 1989-10-10 Leggett & Platt, Incorporated Shelf conversion unit for gondola display
US4886062A (en) * 1987-10-19 1989-12-12 Medtronic, Inc. Intravascular radially expandable stent and method of implant
US4916193A (en) * 1987-12-17 1990-04-10 Allied-Signal Inc. Medical devices fabricated totally or in part from copolymers of recurring units derived from cyclic carbonates and lactides
US4969458A (en) * 1987-07-06 1990-11-13 Medtronic, Inc. Intracoronary stent and method of simultaneous angioplasty and stent implant
US4994298A (en) * 1988-06-07 1991-02-19 Biogold Inc. Method of making a biocompatible prosthesis
US4998923A (en) * 1988-08-11 1991-03-12 Advanced Cardiovascular Systems, Inc. Steerable dilatation catheter
US5019090A (en) * 1988-09-01 1991-05-28 Corvita Corporation Radially expandable endoprosthesis and the like
US5019096A (en) * 1988-02-11 1991-05-28 Trustees Of Columbia University In The City Of New York Infection-resistant compositions, medical devices and surfaces and methods for preparing and using same
US5029877A (en) * 1988-05-20 1991-07-09 Fag Kugelfischer Georg Schafer (Kgaa) Seal for a thread drive
US5034265A (en) * 1983-08-01 1991-07-23 Washington Research Foundation Plasma gas discharge treatment for improving the compatibility of biomaterials
US5049403A (en) * 1989-10-12 1991-09-17 Horsk Hydro A.S. Process for the preparation of surface modified solid substrates
US5053048A (en) * 1988-09-22 1991-10-01 Cordis Corporation Thromboresistant coating
US5059166A (en) * 1989-12-11 1991-10-22 Medical Innovative Technologies R & D Limited Partnership Intra-arterial stent with the capability to inhibit intimal hyperplasia
US5102417A (en) * 1985-11-07 1992-04-07 Expandable Grafts Partnership Expandable intraluminal graft, and method and apparatus for implanting an expandable intraluminal graft
US5133732A (en) * 1987-10-19 1992-07-28 Medtronic, Inc. Intravascular stent
US5135536A (en) * 1991-02-05 1992-08-04 Cordis Corporation Endovascular stent and method
US5182317A (en) * 1988-06-08 1993-01-26 Cardiopulmonics, Inc. Multifunctional thrombo-resistant coatings and methods of manufacture
US5213898A (en) * 1989-10-12 1993-05-25 Norsk Hydro A.S. Process for the preparation of surface modified solid substrates
US5226913A (en) * 1988-09-01 1993-07-13 Corvita Corporation Method of making a radially expandable prosthesis
US5262451A (en) * 1988-06-08 1993-11-16 Cardiopulmonics, Inc. Multifunctional thrombo-resistant coatings and methods of manufacture
US5338770A (en) * 1988-06-08 1994-08-16 Cardiopulmonics, Inc. Gas permeable thrombo-resistant coatings and methods of manufacture
US5383928A (en) * 1992-06-10 1995-01-24 Emory University Stent sheath for local drug delivery
US5474563A (en) * 1993-03-25 1995-12-12 Myler; Richard Cardiovascular stent and retrieval apparatus
US5512005A (en) * 1992-08-28 1996-04-30 Michael P. Short Process and apparatus for automatically engraving stone memorial markers
US5512055A (en) * 1991-02-27 1996-04-30 Leonard Bloom Anti-infective and anti-inflammatory releasing systems for medical devices
US5545208A (en) * 1990-02-28 1996-08-13 Medtronic, Inc. Intralumenal drug eluting prosthesis
US5591227A (en) * 1992-03-19 1997-01-07 Medtronic, Inc. Drug eluting stent
US5624411A (en) * 1993-04-26 1997-04-29 Medtronic, Inc. Intravascular stent and method
US5877224A (en) * 1995-07-28 1999-03-02 Rutgers, The State University Of New Jersey Polymeric drug formulations
US5932627A (en) * 1994-05-12 1999-08-03 Dentsply Gmbh Fluoride releasing dental primer composition and method
US6120536A (en) * 1995-04-19 2000-09-19 Schneider (Usa) Inc. Medical devices with long term non-thrombogenic coatings

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1205743A (en) * 1966-07-15 1970-09-16 Nat Res Dev Surgical dilator
SU660689A1 (en) * 1977-11-25 1979-05-05 Харьковский научно-исследовательский институт общей и неотложной хирургии A.j.kononov's device for fitting prothesis in tubular organ
JPS5825607A (en) * 1981-08-08 1983-02-15 Canon Inc Projecting device
CA1246956A (en) * 1983-10-14 1988-12-20 James Jervis Shape memory alloys
EP0183372A1 (en) * 1984-10-19 1986-06-04 RAYCHEM CORPORATION (a Delaware corporation) Prosthetic stent
US4676341A (en) * 1986-07-21 1987-06-30 Maurice Shaffstall Adjustable roof scaffold jack
SU1457921A1 (en) * 1987-03-10 1989-02-15 Харьковский научно-исследовательский институт общей и неотложной хирургии Self-fixing prosthesis of blood vessel
US6974475B1 (en) * 1987-12-08 2005-12-13 Wall W Henry Angioplasty stent
CA2026604A1 (en) * 1989-10-02 1991-04-03 Rodney G. Wolff Articulated stent
US6231998B1 (en) * 1999-05-04 2001-05-15 Siemens Westinghouse Power Corporation Thermal barrier coating

Patent Citations (89)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US861659A (en) * 1906-10-03 1907-07-30 Edgar F Johnston Flexible shafting.
US3279996A (en) * 1962-08-28 1966-10-18 Jr David M Long Polysiloxane carrier for controlled release of drugs and other agents
US3526005A (en) * 1967-06-29 1970-09-01 Gulf General Atomic Inc Method of preparing an intravascular defect by implanting a pyrolytic carbon coated prosthesis
US3526004A (en) * 1969-05-19 1970-09-01 Fred Brandenberger Necktie and removable knot
US3599641A (en) * 1970-03-13 1971-08-17 David S Sheridan Combination connector and channel closure system for catheters
US3657744A (en) * 1970-05-08 1972-04-25 Univ Minnesota Method for fixing prosthetic implants in a living body
US4069307A (en) * 1970-10-01 1978-01-17 Alza Corporation Drug-delivery device comprising certain polymeric materials for controlled release of drug
US3744596A (en) * 1971-01-12 1973-07-10 Bromsregulator Svenska Ab Pneumatic cylinder-piston unit for railway brake riggings
US3948254A (en) * 1971-11-08 1976-04-06 Alza Corporation Novel drug delivery device
US3932627A (en) * 1974-02-04 1976-01-13 Rescue Products, Inc. Siver-heparin-allantoin complex
US3968800A (en) * 1974-09-17 1976-07-13 Vilasi Joseph A Device for insertion into a body opening
US3952334A (en) * 1974-11-29 1976-04-27 General Atomic Company Biocompatible carbon prosthetic devices
US4076285A (en) * 1975-08-01 1978-02-28 Erika, Inc. Laminar flow connector for conduits
US4323071B1 (en) * 1978-04-24 1990-05-29 Advanced Cardiovascular System
US4323071A (en) * 1978-04-24 1982-04-06 Advanced Catheter Systems, Inc. Vascular guiding catheter assembly and vascular dilating catheter assembly and a combination thereof and methods of making the same
US4321711A (en) * 1978-10-18 1982-03-30 Sumitomo Electric Industries, Ltd. Vascular prosthesis
US4292965A (en) * 1978-12-29 1981-10-06 The Population Council, Inc. Intravaginal ring
US4299226A (en) * 1979-08-08 1981-11-10 Banka Vidya S Coronary dilation method
US4300244A (en) * 1979-09-19 1981-11-17 Carbomedics, Inc. Cardiovascular grafts
US4312920A (en) * 1979-11-07 1982-01-26 The United States Of America As Represented By The Department Of Health & Human Services Polymer alloy blood compatible surface
US4390599A (en) * 1980-07-31 1983-06-28 Raychem Corporation Enhanced recovery memory metal device
US4678466A (en) * 1981-06-25 1987-07-07 Rosenwald Peter L Internal medication delivery method and vehicle
US4553545A (en) * 1981-09-16 1985-11-19 Medinvent S.A. Device for application in blood vessels or other difficultly accessible locations and its use
US4613665A (en) * 1982-02-09 1986-09-23 Olle Larm Process for covalent coupling for the production of conjugates, and polysaccharide containing products thereby obtained
US4810784A (en) * 1982-02-09 1989-03-07 Olle Larm Process for covalent coupling for the production of conjugates, and products hereby obtained
US4565740A (en) * 1982-02-09 1986-01-21 Ird-Biomaterial Ab Surface modified solid substrate and a method for its preparation
US4642111A (en) * 1982-02-12 1987-02-10 Unitika Ltd. Injector filled with an anti-cancer composition
US4655771A (en) * 1982-04-30 1987-04-07 Shepherd Patents S.A. Prosthesis comprising an expansible or contractile tubular body
US4655771B1 (en) * 1982-04-30 1996-09-10 Medinvent Ams Sa Prosthesis comprising an expansible or contractile tubular body
US4512338A (en) * 1983-01-25 1985-04-23 Balko Alexander B Process for restoring patency to body vessels
US4503569A (en) * 1983-03-03 1985-03-12 Dotter Charles T Transluminally placed expandable graft prosthesis
US4550569A (en) * 1983-06-10 1985-11-05 Hitachi, Ltd. Main steam inlet structure for steam turbine
US5034265A (en) * 1983-08-01 1991-07-23 Washington Research Foundation Plasma gas discharge treatment for improving the compatibility of biomaterials
US4656083A (en) * 1983-08-01 1987-04-07 Washington Research Foundation Plasma gas discharge treatment for improving the biocompatibility of biomaterials
US4550447A (en) * 1983-08-03 1985-11-05 Shiley Incorporated Vascular graft prosthesis
US4560374A (en) * 1983-10-17 1985-12-24 Hammerslag Julius G Method for repairing stenotic vessels
US4787899A (en) * 1983-12-09 1988-11-29 Lazarus Harrison M Intraluminal graft device, system and method
US4676241A (en) * 1984-01-16 1987-06-30 W.L.G. Technology Ventilation tube swivel
US4562596A (en) * 1984-04-25 1986-01-07 Elliot Kornberg Aortic graft, device and method for performing an intraluminal abdominal aortic aneurysm repair
US4687482A (en) * 1984-04-27 1987-08-18 Scripps Clinic And Research Foundation Vascular prosthesis
US4753652A (en) * 1984-05-04 1988-06-28 Children's Medical Center Corporation Biomaterial implants which resist calcification
US4580568A (en) * 1984-10-01 1986-04-08 Cook, Incorporated Percutaneous endovascular stent and method for insertion thereof
US4689046A (en) * 1985-03-11 1987-08-25 Carbomedics, Inc. Heart valve prosthesis
US4760849A (en) * 1985-04-10 1988-08-02 Medinvent S.A. Planar blank and a coil spring manufactured therefrom
US4872867A (en) * 1985-06-19 1989-10-10 Ube Industries, Ltd. Compositions having antithrombogenic properties and blood contact medical devices using the same
US4731054A (en) * 1985-07-02 1988-03-15 Sulzer Brothers Limited Medical repository probe
US4753625A (en) * 1985-07-17 1988-06-28 Kabushiki Kaisha Universal Coin pay-out apparatus
US4739762B1 (en) * 1985-11-07 1998-10-27 Expandable Grafts Partnership Expandable intraluminal graft and method and apparatus for implanting an expandable intraluminal graft
US4776337B1 (en) * 1985-11-07 2000-12-05 Cordis Corp Expandable intraluminal graft and method and apparatus for implanting an expandable intraluminal graft
US4739762A (en) * 1985-11-07 1988-04-26 Expandable Grafts Partnership Expandable intraluminal graft, and method and apparatus for implanting an expandable intraluminal graft
US4733665C2 (en) * 1985-11-07 2002-01-29 Expandable Grafts Partnership Expandable intraluminal graft and method and apparatus for implanting an expandable intraluminal graft
US4733665A (en) * 1985-11-07 1988-03-29 Expandable Grafts Partnership Expandable intraluminal graft, and method and apparatus for implanting an expandable intraluminal graft
US5102417A (en) * 1985-11-07 1992-04-07 Expandable Grafts Partnership Expandable intraluminal graft, and method and apparatus for implanting an expandable intraluminal graft
US4776337A (en) * 1985-11-07 1988-10-11 Expandable Grafts Partnership Expandable intraluminal graft, and method and apparatus for implanting an expandable intraluminal graft
US4733665B1 (en) * 1985-11-07 1994-01-11 Expandable Grafts Partnership Expandable intraluminal graft,and method and apparatus for implanting an expandable intraluminal graft
US4768507A (en) * 1986-02-24 1988-09-06 Medinnovations, Inc. Intravascular stent and percutaneous insertion catheter system for the dilation of an arterial stenosis and the prevention of arterial restenosis
US4872567A (en) * 1986-05-23 1989-10-10 Leggett & Platt, Incorporated Shelf conversion unit for gondola display
US4740207A (en) * 1986-09-10 1988-04-26 Kreamer Jeffry W Intralumenal graft
US4735652A (en) * 1986-11-17 1988-04-05 Gte Products Corporation Process for producing agglomerates of aluminum based material
US4800882A (en) * 1987-03-13 1989-01-31 Cook Incorporated Endovascular stent and delivery system
US4969458A (en) * 1987-07-06 1990-11-13 Medtronic, Inc. Intracoronary stent and method of simultaneous angioplasty and stent implant
US5133732A (en) * 1987-10-19 1992-07-28 Medtronic, Inc. Intravascular stent
US4886062A (en) * 1987-10-19 1989-12-12 Medtronic, Inc. Intravascular radially expandable stent and method of implant
US4916193A (en) * 1987-12-17 1990-04-10 Allied-Signal Inc. Medical devices fabricated totally or in part from copolymers of recurring units derived from cyclic carbonates and lactides
US5019096A (en) * 1988-02-11 1991-05-28 Trustees Of Columbia University In The City Of New York Infection-resistant compositions, medical devices and surfaces and methods for preparing and using same
US5029877A (en) * 1988-05-20 1991-07-09 Fag Kugelfischer Georg Schafer (Kgaa) Seal for a thread drive
US4994298A (en) * 1988-06-07 1991-02-19 Biogold Inc. Method of making a biocompatible prosthesis
US5182317A (en) * 1988-06-08 1993-01-26 Cardiopulmonics, Inc. Multifunctional thrombo-resistant coatings and methods of manufacture
US5262451A (en) * 1988-06-08 1993-11-16 Cardiopulmonics, Inc. Multifunctional thrombo-resistant coatings and methods of manufacture
US5338770A (en) * 1988-06-08 1994-08-16 Cardiopulmonics, Inc. Gas permeable thrombo-resistant coatings and methods of manufacture
US4998923A (en) * 1988-08-11 1991-03-12 Advanced Cardiovascular Systems, Inc. Steerable dilatation catheter
US5019090A (en) * 1988-09-01 1991-05-28 Corvita Corporation Radially expandable endoprosthesis and the like
US5226913A (en) * 1988-09-01 1993-07-13 Corvita Corporation Method of making a radially expandable prosthesis
US5053048A (en) * 1988-09-22 1991-10-01 Cordis Corporation Thromboresistant coating
US4856516A (en) * 1989-01-09 1989-08-15 Cordis Corporation Endovascular stent apparatus and method
US5213898A (en) * 1989-10-12 1993-05-25 Norsk Hydro A.S. Process for the preparation of surface modified solid substrates
US5049403A (en) * 1989-10-12 1991-09-17 Horsk Hydro A.S. Process for the preparation of surface modified solid substrates
US5059166A (en) * 1989-12-11 1991-10-22 Medical Innovative Technologies R & D Limited Partnership Intra-arterial stent with the capability to inhibit intimal hyperplasia
US5545208A (en) * 1990-02-28 1996-08-13 Medtronic, Inc. Intralumenal drug eluting prosthesis
US5135536A (en) * 1991-02-05 1992-08-04 Cordis Corporation Endovascular stent and method
US5512055A (en) * 1991-02-27 1996-04-30 Leonard Bloom Anti-infective and anti-inflammatory releasing systems for medical devices
US5591227A (en) * 1992-03-19 1997-01-07 Medtronic, Inc. Drug eluting stent
US5383928A (en) * 1992-06-10 1995-01-24 Emory University Stent sheath for local drug delivery
US5512005A (en) * 1992-08-28 1996-04-30 Michael P. Short Process and apparatus for automatically engraving stone memorial markers
US5474563A (en) * 1993-03-25 1995-12-12 Myler; Richard Cardiovascular stent and retrieval apparatus
US5624411A (en) * 1993-04-26 1997-04-29 Medtronic, Inc. Intravascular stent and method
US5932627A (en) * 1994-05-12 1999-08-03 Dentsply Gmbh Fluoride releasing dental primer composition and method
US6120536A (en) * 1995-04-19 2000-09-19 Schneider (Usa) Inc. Medical devices with long term non-thrombogenic coatings
US5877224A (en) * 1995-07-28 1999-03-02 Rutgers, The State University Of New Jersey Polymeric drug formulations

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10888414B2 (en) 2019-03-20 2021-01-12 inQB8 Medical Technologies, LLC Aortic dissection implant

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US5195984A (en) 1993-03-23
KR900005943A (en) 1990-05-07
EP0364787B1 (en) 1992-03-04
US5902332A (en) 1999-05-11
GR3003987T3 (en) 1993-03-16
GR900300138T1 (en) 1991-09-27
KR0142674B1 (en) 1998-07-01
ES2016233T3 (en) 1992-10-16
JPH02174859A (en) 1990-07-06
CA1322628C (en) 1993-10-05
BR8905130A (en) 1990-05-15
AU623438B2 (en) 1992-05-14
DE364787T1 (en) 1990-12-20
ES2016233A4 (en) 1990-11-01
EP0364787A1 (en) 1990-04-25
US20060149353A1 (en) 2006-07-06
ZA897357B (en) 1990-10-31
ATE72955T1 (en) 1992-03-15
JP2680901B2 (en) 1997-11-19
DE68900929D1 (en) 1992-04-09
US20020133221A1 (en) 2002-09-19
AU4248589A (en) 1990-04-12

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