EP0972498A1 - Radioisotope stent with increased radiation field strength at the ends of the stent - Google Patents

Radioisotope stent with increased radiation field strength at the ends of the stent Download PDF

Info

Publication number
EP0972498A1
EP0972498A1 EP98305727A EP98305727A EP0972498A1 EP 0972498 A1 EP0972498 A1 EP 0972498A1 EP 98305727 A EP98305727 A EP 98305727A EP 98305727 A EP98305727 A EP 98305727A EP 0972498 A1 EP0972498 A1 EP 0972498A1
Authority
EP
European Patent Office
Prior art keywords
stent
radioisotope
per unit
unit length
amount
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP98305727A
Other languages
German (de)
French (fr)
Inventor
Robert E. Fischell
David R. Fischell
Tim A. Fischell
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to US08/567,138 priority Critical patent/US5840009A/en
Priority to CA002241717A priority patent/CA2241717A1/en
Priority to AU76104/98A priority patent/AU7610498A/en
Priority to TW087111173A priority patent/TW386035B/en
Priority to KR1019980028110A priority patent/KR20000008342A/en
Priority to JP10214760A priority patent/JP2000037466A/en
Application filed by Individual filed Critical Individual
Priority to EP98305727A priority patent/EP0972498A1/en
Publication of EP0972498A1 publication Critical patent/EP0972498A1/en
Withdrawn legal-status Critical Current

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/02—Inorganic materials
    • A61L27/04—Metals or alloys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/82—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/95—Instruments specially adapted for placement or removal of stents or stent-grafts
    • A61F2/958—Inflatable balloons for placing stents or stent-grafts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
    • A61N5/1001—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy using radiation sources introduced into or applied onto the body; brachytherapy
    • A61N5/1002—Intraluminal radiation therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2210/00—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2210/0095—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof radioactive

Definitions

  • This invention is in the field of intravascular stents for maintaining vascular patency.
  • Radioisotope stents have been shown to be effective in decreasing neointimal hyperplasia within arteries of laboratory animals thus suggesting a treatment to reduce restenosis in man. By the late 1990's, these stents will be used to prevent vascular closure following balloon angioplasty in human subjects.
  • the radioisotope stents used in animals have had a uniform distribution of a radioisotope that is within the metal of the stent. A uniform distribution of the radioisotope results in a decreased radiation field at the ends of the stent where the highest tendency to form proliferative cell growth can occur.
  • the surface concentration of radioactivity placed at or near the ends of the stent should be increased as compared to the surface concentration of radioactivity over the remainder of the stent.
  • the radiation field at the end of a radioisotope stent is increased by placing an increased amount of radioisotope at the ends of the stent.
  • the radiation field at the end of a radioisotope stent is increased by placing additional metal surfaces at the ends of the stent so as to have additional surfaces onto which a radioisotope can be placed.
  • FIG. 1 is a side view of a cylindrical stent 1 having a radial dimension R, circumferential rings 3 and longitudinals 5.
  • the stent 1 has a uniform distribution of a radioisotope along its length. This uniform distribution has been used conventionally in prior art radioisotope stents. This type of radioisotope stent is described in detail in U.S. Patent No. 5,059,166 which is included herein by reference.
  • the x-axis in FIG. 1 is parallel to the stent's longitudinal axis.
  • the long dashed line 4 in FIG. 1 represents the radiation field intensity or fields strength in human tissue along the surface of a cylinder having a radius of R + 2mm which cylinder surrounds the stent 1.
  • FIG. 2 is a side view of an embodiment of a cylindrical stent 10 according to the invention having longitudinals 11, circumferential rings 13, 15 and 17 and also having an increased concentration of radioisotope placed near the ends of the stent 10.
  • This increased concentration of radioactivity at the ends of the stent is indicated by the solid line 12 of FIG. 2.
  • the resulting field distribution along a cylindrical surface surrounding the stent 1 with a cylindrical radius of R + 2mm is shown by the short dashed line 14 in FIG. 2.
  • the radiation field strength can be made to extend to a greater distance in the x and -x directions beyond the ends of the stent 10.
  • FIG. 2 shows for comparison the line 4 (from FIG. 1) for a uniform concentration of radioisotope in a stent compared to line 14 which is for the non-uniform distribution of radioisotope shown by line 12 in FIG. 2.
  • the radiation field strength at the ends of the surrounding cylindrical surface is greater than the field strength from a uniform concentration of radioisotope as shown by line 4 in FIGS. 1 and 2.
  • the stent 10 may have additional rings 15 placed in near-proximity to the ends of stent 10.
  • the rings 15 provide additional surface area on which to place the radioisotope.
  • the end rings 17 could also be wider so as to provide additional surface onto which additional radioisotope material can be placed. Such additional surfaces can be used to enhance the radiation field intensity at the ends of the stent 10 even if the density of radioisotope per mm 2 of stent surface area is uniform.
  • the stent can be fabricated in a variety of shapes and sizes. It could, for example, be self-expanding as described in U.S. Patent No. 4, 503,569 or balloon expandable as described in U.S. Patent No. 4,733,665. Both of the aforementioned patents are included herein by reference. Still further, the radioisotope could be electrolytically plated onto the stent instead of using ion implantation. The radioisotope could also be plated onto the stent by vapor deposition.
  • the distribution of the radioisotope at the ends of stent can have a different shape than that shown by line 12 in FIG. 2. Specifically, some comparatively short distance at the end of stent could have an increased amount of radioisotope per unit length compared to the stent's center portion, but that higher radioisotope amount per unit length could be uniform near the end of the stent.
  • the longitudinals may be joined by structures other than rings.
  • the longitudinals may have forms other than as illustrated. Indeed, the longitudinals and joining structures could be replaced by other structures.

Abstract

Disclosed is a radioisotope stent that has increased radioactivity at the end regions of the stent as compared to the stent's central region. To minimize the neointimal hyperplasia that may exist to a greater extent at the ends of a stent that is implanted into an artery of a human body, the amount of radioactivity placed at or near the ends of the stent should be increased as compared to the amount of radioactivity over the remainder of the stent. It is an additional object of this invention to increase the radiation field at the end of a radioisotope stent by placing additional metal surfaces at the ends of the stent so as to have additional surfaces onto which a radioisotope can be placed.

Description

    FIELD OF USE
  • This invention is in the field of intravascular stents for maintaining vascular patency.
    • BACKGROUND OF THE INVENTION
  • Radioisotope stents have been shown to be effective in decreasing neointimal hyperplasia within arteries of laboratory animals thus suggesting a treatment to reduce restenosis in man. By the late 1990's, these stents will be used to prevent vascular closure following balloon angioplasty in human subjects. The radioisotope stents used in animals have had a uniform distribution of a radioisotope that is within the metal of the stent. A uniform distribution of the radioisotope results in a decreased radiation field at the ends of the stent where the highest tendency to form proliferative cell growth can occur.
    • SUMMARY OF THE INVENTION
  • Particular and preferred aspects of the invention are set out in the accompanying independent and dependent claims. Features of the dependent claims may be combined with those of the independent claims as appropriate and in combinations other than those explicitly set out in the claims.
  • In an embodiment of the invention, to minimize the neointimal hyperplasia that may exist to a greater extent at the ends of a stent, the surface concentration of radioactivity placed at or near the ends of the stent should be increased as compared to the surface concentration of radioactivity over the remainder of the stent.
  • In an embodiment of the invention, the radiation field at the end of a radioisotope stent is increased by placing an increased amount of radioisotope at the ends of the stent.
  • In an embodiment of the invention, the radiation field at the end of a radioisotope stent is increased by placing additional metal surfaces at the ends of the stent so as to have additional surfaces onto which a radioisotope can be placed.
    • BRIEF DESCRIPTIONS OF THE DRAWINGS
  • Exemplary embodiments of the invention are described hereinafter, by way of example only, with reference to the accompanying drawings, in which:
  • FIG. 1 is a side view of a prior art cylindrical stent having a radioisotope uniformly placed along the length of the stent, and also showing the radiation field strength that results from that uniform distribution of the radioisotope; and
  • FIG. 2 is a side view of a stent having an increased level of radioactivity near the ends of the stent and also showing the radiation field strength resulting from that non-uniform distribution of the radioactivity compared to prior art stents.
    • DETAILED DESCRIPTION OF THE DRAWINGS
  • FIG. 1 is a side view of a cylindrical stent 1 having a radial dimension R, circumferential rings 3 and longitudinals 5. The stent 1 has a uniform distribution of a radioisotope along its length. This uniform distribution has been used conventionally in prior art radioisotope stents. This type of radioisotope stent is described in detail in U.S. Patent No. 5,059,166 which is included herein by reference. The solid line 2 in FIG. 1 represents this uniform distribution of radioisotope along the length L of the stent 1 from its left end which is at a distance x = -L/2 from the center of the stent 1 to its right end which is at a distance of x = + L/2 from the center of the stent 1. The x-axis in FIG. 1 is parallel to the stent's longitudinal axis. The long dashed line 4 in FIG. 1 represents the radiation field intensity or fields strength in human tissue along the surface of a cylinder having a radius of R + 2mm which cylinder surrounds the stent 1. The line 4 indicates the radiation field intensity along the surrounding cylinder from x = -L\2 to x = +L/2 and also along the surrounding cylindrical surface that extends beyond the ends of the stent 1. A theoretical analysis indicates that the radiation field strength in human tissue along the cylindrical surface surrounding the stent 1 is one-half as great at x = -L\2 and x = +L/2 as it is at x = 0 which is at the longitudinal center of the cylindrical surface surrounding the stent 1. As one moves longitudinally outward on the R + 2mm radius surrounding cylindrical surface beyond the ends of the stent 1, the radiation field falls to a negligibly small value at x = -A and x = +A.
  • FIG. 2 is a side view of an embodiment of a cylindrical stent 10 according to the invention having longitudinals 11, circumferential rings 13, 15 and 17 and also having an increased concentration of radioisotope placed near the ends of the stent 10. This increased concentration of radioactivity at the ends of the stent is indicated by the solid line 12 of FIG. 2. The resulting field distribution along a cylindrical surface surrounding the stent 1 with a cylindrical radius of R + 2mm is shown by the short dashed line 14 in FIG. 2. By increasing the concentration of a radioisotope placed near the ends of the stent 10, the radiation field strength at the stent ends can be made equal to the field strength at the center of the stent 10. Furthermore, the radiation field strength can be made to extend to a greater distance in the x and -x directions beyond the ends of the stent 10. Specifically FIG. 2 shows for comparison the line 4 (from FIG. 1) for a uniform concentration of radioisotope in a stent compared to line 14 which is for the non-uniform distribution of radioisotope shown by line 12 in FIG. 2. It is clearly seen in FIG. 2 that the radiation field strength at the ends of the surrounding cylindrical surface is greater than the field strength from a uniform concentration of radioisotope as shown by line 4 in FIGS. 1 and 2. In fact, at x =-B and x = +B in FIG. 2 it can be seen that the radiation field strength along the surface of the R+ 2 mm radius surrounding cylinder extends for a considerable distance beyond x = -A and x = +A. Thus for the same concentration of radioisotope per unit length at the center of the stent for stent 1 and stent 10, a higher level of radioisotope at the ends of stent 10 results in a more uniform radiation field intensity over the length of the surrounding cylinder and also an effective radiation field that extends for a greater distance beyond the ends of the stent 10 and beyond the points x = -L/2 and x = +L/2 of the surrounding cylinder. Having an increased radiation field at the ends of a stent is useful in reducing proliferative cell growth after the stent is placed inside an artery.
  • As seen in FIG. 2, the stent 10 may have additional rings 15 placed in near-proximity to the ends of stent 10. The rings 15 provide additional surface area on which to place the radioisotope. Furthermore, the end rings 17 could also be wider so as to provide additional surface onto which additional radioisotope material can be placed. Such additional surfaces can be used to enhance the radiation field intensity at the ends of the stent 10 even if the density of radioisotope per mm2 of stent surface area is uniform.
  • It should be understood that the stent 10 can be made radioactive by the ion implantation of a radioisotope into the surface of the metal stent. Furthermore, the beam of an ionized radioisotope can be directed so as to place more of the radioisotope near the ends of the stent as compared to at x = 0. Typically a beta particle radioisotope such as phosphorous 32 would be ion implanted into the metal of the stent. Gamma or gamma plus beta particle emitting isotopes can also be used with the stent. Furthermore, it may be advantageous to place an anti-thrombogenic coating on the surface of the stent either before (or preferably) after the radioisotope has been ion implanted into the stent. It should also be understood that the stent can be fabricated in a variety of shapes and sizes. It could, for example, be self-expanding as described in U.S. Patent No. 4, 503,569 or balloon expandable as described in U.S. Patent No. 4,733,665. Both of the aforementioned patents are included herein by reference. Still further, the radioisotope could be electrolytically plated onto the stent instead of using ion implantation. The radioisotope could also be plated onto the stent by vapor deposition. It is also conceived that the distribution of the radioisotope at the ends of stent can have a different shape than that shown by line 12 in FIG. 2. Specifically, some comparatively short distance at the end of stent could have an increased amount of radioisotope per unit length compared to the stent's center portion, but that higher radioisotope amount per unit length could be uniform near the end of the stent.
  • Various other modifications, adaptations, and alternative designs are of course possible in light of the above teachings. Therefore, it should be understood at this time that within the invention may be practiced otherwise than as specifically described herein. For example, the longitudinals may be joined by structures other than rings. Also, the longitudinals may have forms other than as illustrated. Indeed, the longitudinals and joining structures could be replaced by other structures.

Claims (11)

  1. A radioisotope stent comprising means for providing a greater concentration of radioactivity at or near an end section of the stent compared to a concentration of radioactivity intermediate end sections of the stent.
  2. A radioisotope stent comprising a generally cylindrical, thin-walled, metal structure the stent having an end region near each end of the stent and a central region located generally at the longitudinal center of the stent, the stent including a radioactive material which is a radioisotope, the radioisotope being fixedly joined to the metal of the stent, the stent also having a greater amount of radioisotope per unit length of the stent at the end regions of the stent compared to a lesser amount of radioisotope per unit length at the central region of the stent.
  3. The stent of claim 1 or claim 2, wherein the amount of radioisotope per unit length of stent continuously incrases towards the ends of the stent from some point between the center of the stent and the end of the stent, the amount of radioisotope per unit length of stent reaching a maximum amount of radioisotope per unit length at the ends of stent.
  4. The stent of any preceding claim, wherein the radioisotope that is fixedly joined to the stent is a beta-particle emitting radioisotope.
  5. The stent of claim 3, wherein the radioisotope is phosphorous 32.
  6. The stent of any preceding claim, wherein the stent is coated with an antithrombogenic coating.
  7. The stent of any preceding claim, wherein the stent is adapted to be expanded by an inflatable balloon.
  8. The stent of any preceding claim, wherein the stent is adapted to be self-expanding.
  9. The stent of any preceding claim, wherein the metal of the stent has a surface and at least some of the radioisotope is plated onto the surface of the stent to form a surface coating.
  10. The stent of any preceding claim, wherein metal of the stent has a surface and the stent has at least some of the radioisotope ion implanted into the metal of the stent to form a radioactive stent in which the ions of the radioisotope are buried just beneath the surface of the stent.
  11. The stent of any preceding claim, wherein the end region of the stent has more surface area per unit length of the stent as compared to the surface area per unit length of the stent at the stent's central region, the stent having a generally uniform amount of radioisotope per unit surface area of the stent thus providing an increased amount of radioisotope per unit length of the stent at the stent's end regions.
EP98305727A 1995-12-05 1998-07-17 Radioisotope stent with increased radiation field strength at the ends of the stent Withdrawn EP0972498A1 (en)

Priority Applications (7)

Application Number Priority Date Filing Date Title
US08/567,138 US5840009A (en) 1995-12-05 1995-12-05 Radioisotope stent with increased radiation field strength at the ends of the stent
CA002241717A CA2241717A1 (en) 1995-12-05 1998-06-26 Radioisotope stent with increased radiation field strength at the ends of the stent
AU76104/98A AU7610498A (en) 1995-12-05 1998-07-10 Radioisotope stent with increased radiation field strength at the ends of the stent
TW087111173A TW386035B (en) 1995-12-05 1998-07-10 Radioisotope with increased radiation field strength at the ends of the stent
KR1019980028110A KR20000008342A (en) 1995-12-05 1998-07-13 Radioisotope stent having increased radiation field strength in stent end part
JP10214760A JP2000037466A (en) 1995-12-05 1998-07-15 Radioisotope stent increasing dosage at terminal
EP98305727A EP0972498A1 (en) 1995-12-05 1998-07-17 Radioisotope stent with increased radiation field strength at the ends of the stent

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US08/567,138 US5840009A (en) 1995-12-05 1995-12-05 Radioisotope stent with increased radiation field strength at the ends of the stent
CA002241717A CA2241717A1 (en) 1995-12-05 1998-06-26 Radioisotope stent with increased radiation field strength at the ends of the stent
AU76104/98A AU7610498A (en) 1995-12-05 1998-07-10 Radioisotope stent with increased radiation field strength at the ends of the stent
KR1019980028110A KR20000008342A (en) 1995-12-05 1998-07-13 Radioisotope stent having increased radiation field strength in stent end part
JP10214760A JP2000037466A (en) 1995-12-05 1998-07-15 Radioisotope stent increasing dosage at terminal
EP98305727A EP0972498A1 (en) 1995-12-05 1998-07-17 Radioisotope stent with increased radiation field strength at the ends of the stent

Publications (1)

Publication Number Publication Date
EP0972498A1 true EP0972498A1 (en) 2000-01-19

Family

ID=31982710

Family Applications (1)

Application Number Title Priority Date Filing Date
EP98305727A Withdrawn EP0972498A1 (en) 1995-12-05 1998-07-17 Radioisotope stent with increased radiation field strength at the ends of the stent

Country Status (7)

Country Link
US (1) US5840009A (en)
EP (1) EP0972498A1 (en)
JP (1) JP2000037466A (en)
KR (1) KR20000008342A (en)
AU (1) AU7610498A (en)
CA (1) CA2241717A1 (en)
TW (1) TW386035B (en)

Cited By (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002083039A1 (en) * 2001-04-12 2002-10-24 Advanced Cardiovascular Systems, Inc. Variable surface area stent
WO2003020369A3 (en) * 2001-08-28 2003-12-04 Karlsruhe Forschzent Radioactive implant and method for producing the same
US7666223B2 (en) 2002-11-12 2010-02-23 Advanced Cardiovascular Systems, Inc. Stent with drug coating
US7862495B2 (en) 2001-05-31 2011-01-04 Advanced Cardiovascular Systems, Inc. Radiation or drug delivery source with activity gradient to minimize edge effects
US7867547B2 (en) 2005-12-19 2011-01-11 Advanced Cardiovascular Systems, Inc. Selectively coating luminal surfaces of stents
US8003156B2 (en) 2006-05-04 2011-08-23 Advanced Cardiovascular Systems, Inc. Rotatable support elements for stents
US8017237B2 (en) 2006-06-23 2011-09-13 Abbott Cardiovascular Systems, Inc. Nanoshells on polymers
US8025916B2 (en) 2001-06-29 2011-09-27 Abbott Cardiovascular Systems Inc. Methods for forming a composite stent with regioselective material
US8048441B2 (en) 2007-06-25 2011-11-01 Abbott Cardiovascular Systems, Inc. Nanobead releasing medical devices
US8048448B2 (en) 2006-06-15 2011-11-01 Abbott Cardiovascular Systems Inc. Nanoshells for drug delivery
US8197879B2 (en) 2003-09-30 2012-06-12 Advanced Cardiovascular Systems, Inc. Method for selectively coating surfaces of a stent
US8603530B2 (en) 2006-06-14 2013-12-10 Abbott Cardiovascular Systems Inc. Nanoshell therapy

Families Citing this family (75)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE184496T1 (en) 1993-07-01 1999-10-15 Schneider Europ Gmbh MEDICAL DEVICES FOR THE TREATMENT OF BLOOD VESSELS USING IONIZATION RADIATION
ATE166782T1 (en) * 1994-02-25 1998-06-15 Fischell Robert STENT WITH A MULTIPLE CLOSED CIRCULAR STRUCTURES
EP0686342B1 (en) 1994-06-10 1998-09-09 Schneider (Europe) GmbH A medical appliance for the treatment of a portion of body vessel by ionising radiation
EP0965363B1 (en) 1994-06-24 2002-02-13 Schneider (Europe) GmbH Medical appliance for the treatment of a portion of body vessel by ionizing radiation
US6234951B1 (en) 1996-02-29 2001-05-22 Scimed Life Systems, Inc. Intravascular radiation delivery system
US5855546A (en) 1996-02-29 1999-01-05 Sci-Med Life Systems Perfusion balloon and radioactive wire delivery system
US6099454A (en) 1996-02-29 2000-08-08 Scimed Life Systems, Inc. Perfusion balloon and radioactive wire delivery system
IT1289728B1 (en) 1996-12-10 1998-10-16 Sorin Biomedica Cardio Spa SYSTEM AND EQUIPMENT DEVICE THAT INCLUDES IT
US6491619B1 (en) 1997-01-31 2002-12-10 Endologix, Inc Radiation delivery catheters and dosimetry methods
US6458069B1 (en) 1998-02-19 2002-10-01 Endology, Inc. Multi layer radiation delivery balloon
US5782742A (en) 1997-01-31 1998-07-21 Cardiovascular Dynamics, Inc. Radiation delivery balloon
US6287249B1 (en) 1998-02-19 2001-09-11 Radiance Medical Systems, Inc. Thin film radiation source
US6110097A (en) 1997-03-06 2000-08-29 Scimed Life Systems, Inc. Perfusion balloon catheter with radioactive source
US6676590B1 (en) 1997-03-06 2004-01-13 Scimed Life Systems, Inc. Catheter system having tubular radiation source
US6059713A (en) 1997-03-06 2000-05-09 Scimed Life Systems, Inc. Catheter system having tubular radiation source with movable guide wire
US6059812A (en) 1997-03-21 2000-05-09 Schneider (Usa) Inc. Self-expanding medical device for centering radioactive treatment sources in body vessels
US6019718A (en) 1997-05-30 2000-02-01 Scimed Life Systems, Inc. Apparatus for intravascular radioactive treatment
ATE227145T1 (en) 1997-09-26 2002-11-15 Schneider Europ Gmbh BALLOON CATHETER INFLATED WITH CARBON DIOXIDE FOR RADIOTHERAPY
US6471630B1 (en) * 1998-03-24 2002-10-29 Radiomed Corporation Transmutable radiotherapy device
US6264596B1 (en) 1997-11-03 2001-07-24 Meadox Medicals, Inc. In-situ radioactive medical device
US6187037B1 (en) * 1998-03-11 2001-02-13 Stanley Satz Metal stent containing radioactivatable isotope and method of making same
US6293899B1 (en) 1998-03-24 2001-09-25 Radiomed Corporation Transmutable radiotherapy device
DE19819635A1 (en) * 1998-05-05 1999-11-11 Jomed Implantate Gmbh Radioactive stent
US20060078493A1 (en) * 1998-05-05 2006-04-13 Randolf Von Oepen Methods and apparatus for localized administration of inhibitory moieties to a patient
US6296603B1 (en) * 1998-05-26 2001-10-02 Isostent, Inc. Radioactive intraluminal endovascular prosthesis and method for the treatment of aneurysms
US6413203B1 (en) 1998-09-16 2002-07-02 Scimed Life Systems, Inc. Method and apparatus for positioning radioactive fluids within a body lumen
US6099455A (en) * 1998-11-25 2000-08-08 Isostent, Inc. Radioisotope stent with non-radioactive end sections
US6264595B1 (en) 1999-02-04 2001-07-24 Mobeta, Inc. Radioactive transition metal stents
DE19921088C2 (en) * 1999-04-30 2003-08-07 Magforce Applic Gmbh Stent to keep aisle-like structures open
SE523926C2 (en) * 1999-06-15 2004-06-01 Hans Lundqvist stent Events
US6547816B1 (en) 1999-07-12 2003-04-15 Civatech Corporation Formable integral source material for medical devices
FR2797175A1 (en) 1999-08-02 2001-02-09 Jacques Seguin Device for treatment of narrowing of vascular blood vessel or bilious duct, comprises catheter, radially extensible tubular element called stent, mounted on catheter, and means of expansion and radial deployment of stent
US6352501B1 (en) 1999-09-23 2002-03-05 Scimed Life Systems, Inc. Adjustable radiation source
US6203485B1 (en) 1999-10-07 2001-03-20 Scimed Life Systems, Inc. Low attenuation guide wire for intravascular radiation delivery
US6398709B1 (en) 1999-10-19 2002-06-04 Scimed Life Systems, Inc. Elongated member for intravascular delivery of radiation
US6436026B1 (en) 1999-10-22 2002-08-20 Radiomed Corporation Flexible, continuous, axially elastic interstitial brachytherapy source
US6733513B2 (en) 1999-11-04 2004-05-11 Advanced Bioprosthetic Surfaces, Ltd. Balloon catheter having metal balloon and method of making same
US6368266B1 (en) 1999-11-12 2002-04-09 Vascular Architects, Inc. Medical irradiation assembly and method
US7235092B2 (en) 1999-11-19 2007-06-26 Advanced Bio Prosthetic Surfaces, Ltd. Guidewires and thin film catheter-sheaths and method of making same
US6849085B2 (en) 1999-11-19 2005-02-01 Advanced Bio Prosthetic Surfaces, Ltd. Self-supporting laminated films, structural materials and medical devices manufactured therefrom and method of making same
US6379383B1 (en) 1999-11-19 2002-04-30 Advanced Bio Prosthetic Surfaces, Ltd. Endoluminal device exhibiting improved endothelialization and method of manufacture thereof
US10172730B2 (en) 1999-11-19 2019-01-08 Vactronix Scientific, Llc Stents with metallic covers and methods of making same
US6936066B2 (en) 1999-11-19 2005-08-30 Advanced Bio Prosthetic Surfaces, Ltd. Complaint implantable medical devices and methods of making same
US7736687B2 (en) 2006-01-31 2010-06-15 Advance Bio Prosthetic Surfaces, Ltd. Methods of making medical devices
US7195641B2 (en) 1999-11-19 2007-03-27 Advanced Bio Prosthetic Surfaces, Ltd. Valvular prostheses having metal or pseudometallic construction and methods of manufacture
US7300457B2 (en) 1999-11-19 2007-11-27 Advanced Bio Prosthetic Surfaces, Ltd. Self-supporting metallic implantable grafts, compliant implantable medical devices and methods of making same
US8458879B2 (en) * 2001-07-03 2013-06-11 Advanced Bio Prosthetic Surfaces, Ltd., A Wholly Owned Subsidiary Of Palmaz Scientific, Inc. Method of fabricating an implantable medical device
US6537310B1 (en) 1999-11-19 2003-03-25 Advanced Bio Prosthetic Surfaces, Ltd. Endoluminal implantable devices and method of making same
ATE352268T1 (en) 1999-11-23 2007-02-15 Sorin Biomedica Cardio Srl METHOD FOR TRANSFER OF RADIOACTIVE SUBSTANCES TO STENTS IN ANGIOPLASTY AND KIT
US6416457B1 (en) 2000-03-09 2002-07-09 Scimed Life Systems, Inc. System and method for intravascular ionizing tandem radiation therapy
US6302865B1 (en) 2000-03-13 2001-10-16 Scimed Life Systems, Inc. Intravascular guidewire with perfusion lumen
US6695865B2 (en) 2000-03-20 2004-02-24 Advanced Bio Prosthetic Surfaces, Ltd. Embolic protection device
US6315708B1 (en) * 2000-03-31 2001-11-13 Cordis Corporation Stent with self-expanding end sections
US8845713B2 (en) 2000-05-12 2014-09-30 Advanced Bio Prosthetic Surfaces, Ltd., A Wholly Owned Subsidiary Of Palmaz Scientific, Inc. Self-supporting laminated films, structural materials and medical devices manufactured therefrom and methods of making same
US8236048B2 (en) * 2000-05-12 2012-08-07 Cordis Corporation Drug/drug delivery systems for the prevention and treatment of vascular disease
AU2002233936A1 (en) 2000-11-07 2002-05-21 Advanced Bio Prosthetic Surfaces, Ltd. Endoluminal stent, self-fupporting endoluminal graft and methods of making same
US20030069634A1 (en) * 2001-05-16 2003-04-10 Susan Bialecke Two-step method to deposit and secure a chemical species coating onto a medical device
AU2003270817B2 (en) 2002-09-26 2009-09-17 Vactronix Scientific, Llc High strength vacuum deposited nitionol alloy films, medical thin film graft materials and method of making same
US6918869B2 (en) 2002-12-02 2005-07-19 Scimed Life Systems System for administering a combination of therapies to a body lumen
US7766973B2 (en) 2005-01-19 2010-08-03 Gi Dynamics, Inc. Eversion resistant sleeves
US7122058B2 (en) 2002-12-02 2006-10-17 Gi Dynamics, Inc. Anti-obesity devices
US7608114B2 (en) 2002-12-02 2009-10-27 Gi Dynamics, Inc. Bariatric sleeve
US7695446B2 (en) 2002-12-02 2010-04-13 Gi Dynamics, Inc. Methods of treatment using a bariatric sleeve
US7025791B2 (en) 2002-12-02 2006-04-11 Gi Dynamics, Inc. Bariatric sleeve
US7678068B2 (en) 2002-12-02 2010-03-16 Gi Dynamics, Inc. Atraumatic delivery devices
WO2005060882A1 (en) 2003-12-09 2005-07-07 Gi Dynamics, Inc. Apparatus to be anchored within the gastrointestinal tract and anchoring method
US8057420B2 (en) 2003-12-09 2011-11-15 Gi Dynamics, Inc. Gastrointestinal implant with drawstring
ATE506042T1 (en) 2004-07-09 2011-05-15 Gi Dynamics Inc DEVICES FOR PLACEMENT OF A GASTROINTESTINAL SLEEVE
US7815591B2 (en) 2004-09-17 2010-10-19 Gi Dynamics, Inc. Atraumatic gastrointestinal anchor
US7771382B2 (en) 2005-01-19 2010-08-10 Gi Dynamics, Inc. Resistive anti-obesity devices
US8834338B2 (en) * 2005-02-10 2014-09-16 Snip Holdings, Inc. Dosimetry implant for treating restenosis and hyperplasia
US7976488B2 (en) 2005-06-08 2011-07-12 Gi Dynamics, Inc. Gastrointestinal anchor compliance
US7819836B2 (en) 2006-06-23 2010-10-26 Gi Dynamics, Inc. Resistive anti-obesity devices
WO2008027402A2 (en) * 2006-08-29 2008-03-06 Civatech Oncology Brachytherapy devices and related methods and computer program products
US8801647B2 (en) 2007-02-22 2014-08-12 Gi Dynamics, Inc. Use of a gastrointestinal sleeve to treat bariatric surgery fistulas and leaks

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0045627A1 (en) * 1980-07-31 1982-02-10 RAYCHEM CORPORATION (a California corporation) Enhanced recovery memory metal device
EP0497495A2 (en) * 1991-01-29 1992-08-05 Med Institute, Inc. A minimally invasive medical device
EP0775505A1 (en) * 1991-01-29 1997-05-28 Med Institute, Inc. A minimally invasive medical device for providing a radiation treatment
EP0824902A1 (en) * 1996-08-23 1998-02-25 Nozomu Kanesaka Expandable stent
US5722984A (en) * 1996-01-16 1998-03-03 Iso Stent, Inc. Antithrombogenic radioactive coating for an intravascular stent

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5176617A (en) * 1989-12-11 1993-01-05 Medical Innovative Technologies R & D Limited Partnership Use of a stent with the capability to inhibit malignant growth in a vessel such as a biliary duct
US5059166A (en) * 1989-12-11 1991-10-22 Medical Innovative Technologies R & D Limited Partnership Intra-arterial stent with the capability to inhibit intimal hyperplasia

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0045627A1 (en) * 1980-07-31 1982-02-10 RAYCHEM CORPORATION (a California corporation) Enhanced recovery memory metal device
EP0497495A2 (en) * 1991-01-29 1992-08-05 Med Institute, Inc. A minimally invasive medical device
EP0775505A1 (en) * 1991-01-29 1997-05-28 Med Institute, Inc. A minimally invasive medical device for providing a radiation treatment
US5722984A (en) * 1996-01-16 1998-03-03 Iso Stent, Inc. Antithrombogenic radioactive coating for an intravascular stent
EP0824902A1 (en) * 1996-08-23 1998-02-25 Nozomu Kanesaka Expandable stent

Cited By (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6764505B1 (en) 2001-04-12 2004-07-20 Advanced Cardiovascular Systems, Inc. Variable surface area stent
US7674493B2 (en) 2001-04-12 2010-03-09 Advanced Cardiovascular Systems, Inc. Method of making a variable surface area stent
US8119184B2 (en) 2001-04-12 2012-02-21 Advanced Cardiovascular Systems, Inc. Method of making a variable surface area stent
WO2002083039A1 (en) * 2001-04-12 2002-10-24 Advanced Cardiovascular Systems, Inc. Variable surface area stent
US7862495B2 (en) 2001-05-31 2011-01-04 Advanced Cardiovascular Systems, Inc. Radiation or drug delivery source with activity gradient to minimize edge effects
US8961584B2 (en) 2001-06-29 2015-02-24 Abbott Cardiovascular Systems Inc. Composite stent with regioselective material
US8025916B2 (en) 2001-06-29 2011-09-27 Abbott Cardiovascular Systems Inc. Methods for forming a composite stent with regioselective material
WO2003020369A3 (en) * 2001-08-28 2003-12-04 Karlsruhe Forschzent Radioactive implant and method for producing the same
US7824440B2 (en) 2002-11-12 2010-11-02 Advanced Cardiovascular Systems, Inc. Stent with drug coating
US7820229B2 (en) 2002-11-12 2010-10-26 Advanced Cardiovascular Systems, Inc. Method of coating a stent
US7824441B2 (en) 2002-11-12 2010-11-02 Advanced Cardiovascular Systems, Inc. Stent with drug coating
US7666223B2 (en) 2002-11-12 2010-02-23 Advanced Cardiovascular Systems, Inc. Stent with drug coating
US8197879B2 (en) 2003-09-30 2012-06-12 Advanced Cardiovascular Systems, Inc. Method for selectively coating surfaces of a stent
US7867547B2 (en) 2005-12-19 2011-01-11 Advanced Cardiovascular Systems, Inc. Selectively coating luminal surfaces of stents
US8003156B2 (en) 2006-05-04 2011-08-23 Advanced Cardiovascular Systems, Inc. Rotatable support elements for stents
US8637110B2 (en) 2006-05-04 2014-01-28 Advanced Cardiovascular Systems, Inc. Rotatable support elements for stents
US8465789B2 (en) 2006-05-04 2013-06-18 Advanced Cardiovascular Systems, Inc. Rotatable support elements for stents
US8741379B2 (en) 2006-05-04 2014-06-03 Advanced Cardiovascular Systems, Inc. Rotatable support elements for stents
US8596215B2 (en) 2006-05-04 2013-12-03 Advanced Cardiovascular Systems, Inc. Rotatable support elements for stents
US8808342B2 (en) 2006-06-14 2014-08-19 Abbott Cardiovascular Systems Inc. Nanoshell therapy
US8603530B2 (en) 2006-06-14 2013-12-10 Abbott Cardiovascular Systems Inc. Nanoshell therapy
US8048448B2 (en) 2006-06-15 2011-11-01 Abbott Cardiovascular Systems Inc. Nanoshells for drug delivery
US8293367B2 (en) 2006-06-23 2012-10-23 Advanced Cardiovascular Systems, Inc. Nanoshells on polymers
US8592036B2 (en) 2006-06-23 2013-11-26 Abbott Cardiovascular Systems Inc. Nanoshells on polymers
US8017237B2 (en) 2006-06-23 2011-09-13 Abbott Cardiovascular Systems, Inc. Nanoshells on polymers
US8048441B2 (en) 2007-06-25 2011-11-01 Abbott Cardiovascular Systems, Inc. Nanobead releasing medical devices

Also Published As

Publication number Publication date
US5840009A (en) 1998-11-24
JP2000037466A (en) 2000-02-08
TW386035B (en) 2000-04-01
KR20000008342A (en) 2000-02-07
AU7610498A (en) 2000-02-03
CA2241717A1 (en) 1999-12-26

Similar Documents

Publication Publication Date Title
US5840009A (en) Radioisotope stent with increased radiation field strength at the ends of the stent
AU624310B2 (en) Intra-arterial stent with the capability to inhibit intimal hyperplasia
US5176617A (en) Use of a stent with the capability to inhibit malignant growth in a vessel such as a biliary duct
US7887579B2 (en) Active stent
US5722984A (en) Antithrombogenic radioactive coating for an intravascular stent
EP0891166B1 (en) Radiopaque stent markers
AU757255B2 (en) Multilayered metal stent
US5919126A (en) Coronary stent with a radioactive, radiopaque coating
US6638302B1 (en) Stent for angioplasty and associated production process
US6192271B1 (en) Radiotherapy stent
WO1999039765A3 (en) Soft x-ray emitting medical devices
EP0893107A1 (en) Expandable stent
US8834338B2 (en) Dosimetry implant for treating restenosis and hyperplasia
EP1290984A3 (en) Protective coating for a stent with intermediate radiopaque coating
CA2597302A1 (en) Methods and apparatus for treatment of luminal hyperplasia
MXPA98006488A (en) Stent with radioisotopes with greater intensity of radiation field at the extremes of the st
Hehrlein Radioactive stents
EP1667607B1 (en) Active stent
Noll et al. 1. 186/188Re Labelled Stents for Prophylaxis of Restenosis: First Animal Results

Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

AK Designated contracting states

Kind code of ref document: A1

Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

AX Request for extension of the european patent

Free format text: AL;LT;LV;MK;RO;SI

17P Request for examination filed

Effective date: 20000628

AKX Designation fees paid

Free format text: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

AXX Extension fees paid

Free format text: AL PAYMENT 20000628;LT PAYMENT 20000628;LV PAYMENT 20000628;MK PAYMENT 20000628;RO PAYMENT 20000628;SI PAYMENT 20000628

17Q First examination report despatched

Effective date: 20010727

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN

18D Application deemed to be withdrawn

Effective date: 20011207