EP0773719A4 - COMPOSITIONS FOR TARGETING MATERIALS TO CELLS CONTAINING ANDROGENIC RECEPTORS - Google Patents
COMPOSITIONS FOR TARGETING MATERIALS TO CELLS CONTAINING ANDROGENIC RECEPTORSInfo
- Publication number
- EP0773719A4 EP0773719A4 EP95926328A EP95926328A EP0773719A4 EP 0773719 A4 EP0773719 A4 EP 0773719A4 EP 95926328 A EP95926328 A EP 95926328A EP 95926328 A EP95926328 A EP 95926328A EP 0773719 A4 EP0773719 A4 EP 0773719A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- compositions
- cells containing
- androgen receptors
- containing androgen
- targeting materials
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/0038—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 with an androstane skeleton, including 18- or 19-substituted derivatives, 18-nor derivatives and also derivatives where position 17-beta is substituted by a carbon atom not directly bonded to a further carbon atom and not being part of an amide group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
- A61K47/645—Polycationic or polyanionic oligopeptides, polypeptides or polyamino acids, e.g. polylysine, polyarginine, polyglutamic acid or peptide TAT
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/0493—Steroids, e.g. cholesterol, testosterone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/088—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins conjugates with carriers being peptides, polyamino acids or proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2123/00—Preparations for testing in vivo
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/283,238 US6468981B1 (en) | 1994-07-29 | 1994-07-29 | Compositions and methods for targeting pharmaceutically active materials to cells containing androgen receptors |
US283238 | 1994-07-29 | ||
PCT/US1995/009293 WO1996003875A1 (en) | 1994-07-29 | 1995-07-24 | Compositions for targeting materials to cells containing androgen receptors |
Publications (2)
Publication Number | Publication Date |
---|---|
EP0773719A1 EP0773719A1 (en) | 1997-05-21 |
EP0773719A4 true EP0773719A4 (en) | 1998-09-02 |
Family
ID=23085145
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP95926328A Ceased EP0773719A4 (en) | 1994-07-29 | 1995-07-24 | COMPOSITIONS FOR TARGETING MATERIALS TO CELLS CONTAINING ANDROGENIC RECEPTORS |
Country Status (5)
Country | Link |
---|---|
US (1) | US6468981B1 (it) |
EP (1) | EP0773719A4 (it) |
AU (1) | AU3071995A (it) |
CA (1) | CA2197770A1 (it) |
WO (1) | WO1996003875A1 (it) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1996027008A2 (de) * | 1995-02-28 | 1996-09-06 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V., Berlin | Mittel zur therapie von tumoren und anderen hyperplasien |
CA2239976A1 (en) * | 1995-09-20 | 1997-03-27 | Paul A. Zamecnik | Antisense oligonucleotide chemotherapy for benign hyperplasia or cancer of the prostate |
EP0856052A1 (en) * | 1995-09-20 | 1998-08-05 | University of Massachusetts | Antisense oligonucleotide chemotherapy for benign hyperplasia or cancer of the prostate |
WO2000011019A1 (en) * | 1998-08-21 | 2000-03-02 | Felix Frey | Conjugates of dna interacting groups with steroid hormones for use as nucleic acid transfection agent |
DE60236520D1 (de) * | 2001-08-16 | 2010-07-08 | Univ Pennsylvania | Synthese und verwendung von reagenzien für die verbesserte dna-lipofektion und/oder prodrug- und arzneimitteltherapien mit langsamer freisetzung |
US7332525B2 (en) * | 2003-01-17 | 2008-02-19 | Castle Erik P | Method of treatment of prostate cancer and composition for treatment thereof |
US20070287680A1 (en) * | 2004-05-10 | 2007-12-13 | University Of Utah Research Foundation | Combined Active and Passive Targeting of Biologically Active Agents |
EP1844793A1 (en) * | 2006-04-13 | 2007-10-17 | D'Angelo, Sante | Cyclic AMP binding molecule as vehicle for gene therapy |
Citations (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1991003162A1 (en) * | 1989-08-31 | 1991-03-21 | City Of Hope | Chimeric dna-rna catalytic sequences |
WO1992014493A1 (en) * | 1991-02-20 | 1992-09-03 | Christopher Capelli | Non-protein intracellular receptor binding conjugates and a method of use thereof |
WO1992019749A1 (en) * | 1991-05-03 | 1992-11-12 | The Board Of Regents Acting For And On Behalf Of The University Of Michigan | Targeted delivery of genes encoding cell surface receptors |
WO1992022635A1 (en) * | 1991-06-05 | 1992-12-23 | University Of Connecticut | Targeted delivery of genes encoding secretory proteins |
WO1993005162A1 (en) * | 1991-08-28 | 1993-03-18 | The University Of Tennessee Research Corporation | Method for delivering nucleic acids into cells |
WO1993007883A1 (en) * | 1991-10-24 | 1993-04-29 | Isis Pharmaceuticals, Inc. | Derivatized oligonucleotides having improved uptake and other properties |
WO1993025197A1 (en) * | 1992-06-12 | 1993-12-23 | Affymax Technologies N.V. | Compositions and methods for enhanced drug delivery |
WO1994004696A1 (en) * | 1992-08-25 | 1994-03-03 | Miles Inc. | Translocation signal facilitated nuclear delivery of macromolecules |
DE4308095A1 (de) * | 1993-03-13 | 1994-09-15 | Hoechst Ag | Prodrug-Derivate von Arzneimittelwirkstoffen mit Hydroxylgruppen, Verfahren zu deren Herstellung und ihre Verwendung |
WO1994023751A1 (de) * | 1993-04-14 | 1994-10-27 | Boehringer Mannheim Gmbh | Nukleinsäure-transferpeptide und deren verwendung zur einschleusung von nukleinsäuren in eukaryontische zellen |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5166320A (en) * | 1987-04-22 | 1992-11-24 | University Of Connecticut | Carrier system and method for the introduction of genes into mammalian cells |
ES2078521T3 (es) | 1990-05-18 | 1995-12-16 | Boehringer Ingelheim Int | Nuevos conjugados de proteina-polication. |
NZ244306A (en) | 1991-09-30 | 1995-07-26 | Boehringer Ingelheim Int | Composition for introducing nucleic acid complexes into eucaryotic cells, complex containing nucleic acid and endosomolytic agent, peptide with endosomolytic domain and nucleic acid binding domain and preparation |
-
1994
- 1994-07-29 US US08/283,238 patent/US6468981B1/en not_active Expired - Fee Related
-
1995
- 1995-07-24 CA CA002197770A patent/CA2197770A1/en not_active Abandoned
- 1995-07-24 AU AU30719/95A patent/AU3071995A/en not_active Abandoned
- 1995-07-24 WO PCT/US1995/009293 patent/WO1996003875A1/en not_active Application Discontinuation
- 1995-07-24 EP EP95926328A patent/EP0773719A4/en not_active Ceased
Patent Citations (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1991003162A1 (en) * | 1989-08-31 | 1991-03-21 | City Of Hope | Chimeric dna-rna catalytic sequences |
WO1992014493A1 (en) * | 1991-02-20 | 1992-09-03 | Christopher Capelli | Non-protein intracellular receptor binding conjugates and a method of use thereof |
WO1992019749A1 (en) * | 1991-05-03 | 1992-11-12 | The Board Of Regents Acting For And On Behalf Of The University Of Michigan | Targeted delivery of genes encoding cell surface receptors |
WO1992022635A1 (en) * | 1991-06-05 | 1992-12-23 | University Of Connecticut | Targeted delivery of genes encoding secretory proteins |
WO1993005162A1 (en) * | 1991-08-28 | 1993-03-18 | The University Of Tennessee Research Corporation | Method for delivering nucleic acids into cells |
WO1993007883A1 (en) * | 1991-10-24 | 1993-04-29 | Isis Pharmaceuticals, Inc. | Derivatized oligonucleotides having improved uptake and other properties |
WO1993025197A1 (en) * | 1992-06-12 | 1993-12-23 | Affymax Technologies N.V. | Compositions and methods for enhanced drug delivery |
WO1994004696A1 (en) * | 1992-08-25 | 1994-03-03 | Miles Inc. | Translocation signal facilitated nuclear delivery of macromolecules |
DE4308095A1 (de) * | 1993-03-13 | 1994-09-15 | Hoechst Ag | Prodrug-Derivate von Arzneimittelwirkstoffen mit Hydroxylgruppen, Verfahren zu deren Herstellung und ihre Verwendung |
WO1994023751A1 (de) * | 1993-04-14 | 1994-10-27 | Boehringer Mannheim Gmbh | Nukleinsäure-transferpeptide und deren verwendung zur einschleusung von nukleinsäuren in eukaryontische zellen |
Non-Patent Citations (5)
Title |
---|
C. WU ET AL: "Tageting Genes: Delivery and Persistent Expression of a Foreign Gene Driven by Mammalian Regulatory Elements in Vivo", JOURNAL OF BIOLOGICAL CHEMISTRY., vol. 264, no. 29, 15 October 1989 (1989-10-15), MD US, pages 16985 - 16987, XP002065973 * |
G. WU ET AL: "Receptor Mediated Gene Delivery In Vivo", JOURNAL OF BIOLOGICAL CHEMISTRY., vol. 266, no. 22, 5 August 1991 (1991-08-05), MD US, pages 14338 - 14342, XP002065972 * |
J. WILSON ET AL: "Hepatocyte-directed Gene Transfer in Vivo Leads to Transient Improvement of Hypercholesterolemia in Low Density Lipoprotein Receptor-deficient Rabbits", JOURNAL OF BIOLOGICAL CHEMISTRY., vol. 267, no. 2, 15 January 1992 (1992-01-15), MD US, pages 963 - 967, XP002065974 * |
M. BHATTACHARJEE ET AL: "Protein Purification Using a Soluble Affinity Matrix: Purification of Estrogen Receptor with Estradiol-Polylysine Conjugate", ANALYTICAL BIOCHEMISTRY., vol. 201, no. 2, March 1992 (1992-03-01), NEW YORK US, pages 233 - 236, XP002065971 * |
See also references of WO9603875A1 * |
Also Published As
Publication number | Publication date |
---|---|
US6468981B1 (en) | 2002-10-22 |
AU3071995A (en) | 1996-03-04 |
CA2197770A1 (en) | 1996-02-15 |
EP0773719A1 (en) | 1997-05-21 |
WO1996003875A1 (en) | 1996-02-15 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
|
17P | Request for examination filed |
Effective date: 19970220 |
|
AK | Designated contracting states |
Kind code of ref document: A1 Designated state(s): AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE |
|
A4 | Supplementary search report drawn up and despatched |
Effective date: 19980714 |
|
AK | Designated contracting states |
Kind code of ref document: A4 Designated state(s): AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE |
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17Q | First examination report despatched |
Effective date: 20000705 |
|
GRAG | Despatch of communication of intention to grant |
Free format text: ORIGINAL CODE: EPIDOS AGRA |
|
STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE APPLICATION HAS BEEN REFUSED |
|
18R | Application refused |
Effective date: 20020927 |