DE69712063T2 - Mikrochip-arzneistoffverabreichnungssysteme - Google Patents

Mikrochip-arzneistoffverabreichnungssysteme

Info

Publication number
DE69712063T2
DE69712063T2 DE69712063T DE69712063T DE69712063T2 DE 69712063 T2 DE69712063 T2 DE 69712063T2 DE 69712063 T DE69712063 T DE 69712063T DE 69712063 T DE69712063 T DE 69712063T DE 69712063 T2 DE69712063 T2 DE 69712063T2
Authority
DE
Germany
Prior art keywords
molecules
release
reservoirs
materials
delivered
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69712063T
Other languages
English (en)
Other versions
DE69712063D1 (de
Inventor
John T Santini
Michael J Cima
Robert S Langer
Achim M Gopferich
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Massachusetts Institute of Technology
Original Assignee
Massachusetts Institute of Technology
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Massachusetts Institute of Technology filed Critical Massachusetts Institute of Technology
Publication of DE69712063D1 publication Critical patent/DE69712063D1/de
Application granted granted Critical
Publication of DE69712063T2 publication Critical patent/DE69712063T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
    • A61K9/0009—Galenical forms characterised by the drug release technique; Application systems commanded by energy involving or responsive to electricity, magnetism or acoustic waves; Galenical aspects of sonophoresis, iontophoresis, electroporation or electroosmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0097—Micromachined devices; Microelectromechanical systems [MEMS]; Devices obtained by lithographic treatment of silicon; Devices comprising chips
    • C—CHEMISTRY; METALLURGY
    • C25—ELECTROLYTIC OR ELECTROPHORETIC PROCESSES; APPARATUS THEREFOR
    • C25F—PROCESSES FOR THE ELECTROLYTIC REMOVAL OF MATERIALS FROM OBJECTS; APPARATUS THEREFOR
    • C25F7/00—Constructional parts, or assemblies thereof, of cells for electrolytic removal of material from objects; Servicing or operating
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/02—General characteristics of the apparatus characterised by a particular materials
    • A61M2205/0244—Micromachined materials, e.g. made from silicon wafers, microelectromechanical systems [MEMS] or comprising nanotechnology
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
DE69712063T 1996-07-02 1997-07-02 Mikrochip-arzneistoffverabreichnungssysteme Expired - Lifetime DE69712063T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/675,375 US5797898A (en) 1996-07-02 1996-07-02 Microchip drug delivery devices
PCT/US1997/011589 WO1998000107A2 (en) 1996-07-02 1997-07-02 Microchip drug delivery devices

Publications (2)

Publication Number Publication Date
DE69712063D1 DE69712063D1 (de) 2002-05-23
DE69712063T2 true DE69712063T2 (de) 2002-10-24

Family

ID=24710206

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69712063T Expired - Lifetime DE69712063T2 (de) 1996-07-02 1997-07-02 Mikrochip-arzneistoffverabreichnungssysteme

Country Status (10)

Country Link
US (2) US5797898A (de)
EP (1) EP0914092B1 (de)
JP (2) JP2000513725A (de)
AT (1) ATE216219T1 (de)
CA (1) CA2258898C (de)
DE (1) DE69712063T2 (de)
DK (1) DK0914092T3 (de)
ES (1) ES2176768T3 (de)
PT (1) PT914092E (de)
WO (1) WO1998000107A2 (de)

Cited By (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7931683B2 (en) 2007-07-27 2011-04-26 Boston Scientific Scimed, Inc. Articles having ceramic coated surfaces
US7938855B2 (en) 2007-11-02 2011-05-10 Boston Scientific Scimed, Inc. Deformable underlayer for stent
US7942926B2 (en) 2007-07-11 2011-05-17 Boston Scientific Scimed, Inc. Endoprosthesis coating
US7976915B2 (en) 2007-05-23 2011-07-12 Boston Scientific Scimed, Inc. Endoprosthesis with select ceramic morphology
US7981150B2 (en) 2006-11-09 2011-07-19 Boston Scientific Scimed, Inc. Endoprosthesis with coatings
US8002823B2 (en) 2007-07-11 2011-08-23 Boston Scientific Scimed, Inc. Endoprosthesis coating
US8029554B2 (en) 2007-11-02 2011-10-04 Boston Scientific Scimed, Inc. Stent with embedded material
US8066763B2 (en) 1998-04-11 2011-11-29 Boston Scientific Scimed, Inc. Drug-releasing stent with ceramic-containing layer
US8067054B2 (en) 2007-04-05 2011-11-29 Boston Scientific Scimed, Inc. Stents with ceramic drug reservoir layer and methods of making and using the same
US8071156B2 (en) 2009-03-04 2011-12-06 Boston Scientific Scimed, Inc. Endoprostheses
US8070797B2 (en) 2007-03-01 2011-12-06 Boston Scientific Scimed, Inc. Medical device with a porous surface for delivery of a therapeutic agent
US8187620B2 (en) 2006-03-27 2012-05-29 Boston Scientific Scimed, Inc. Medical devices comprising a porous metal oxide or metal material and a polymer coating for delivering therapeutic agents
US8216632B2 (en) 2007-11-02 2012-07-10 Boston Scientific Scimed, Inc. Endoprosthesis coating
US8221822B2 (en) 2007-07-31 2012-07-17 Boston Scientific Scimed, Inc. Medical device coating by laser cladding
US8231980B2 (en) 2008-12-03 2012-07-31 Boston Scientific Scimed, Inc. Medical implants including iridium oxide
US8287937B2 (en) 2009-04-24 2012-10-16 Boston Scientific Scimed, Inc. Endoprosthese
US8353949B2 (en) 2006-09-14 2013-01-15 Boston Scientific Scimed, Inc. Medical devices with drug-eluting coating
US8431149B2 (en) 2007-03-01 2013-04-30 Boston Scientific Scimed, Inc. Coated medical devices for abluminal drug delivery
US8449603B2 (en) 2008-06-18 2013-05-28 Boston Scientific Scimed, Inc. Endoprosthesis coating
US8574615B2 (en) 2006-03-24 2013-11-05 Boston Scientific Scimed, Inc. Medical devices having nanoporous coatings for controlled therapeutic agent delivery
US8771343B2 (en) 2006-06-29 2014-07-08 Boston Scientific Scimed, Inc. Medical devices with selective titanium oxide coatings
US8815275B2 (en) 2006-06-28 2014-08-26 Boston Scientific Scimed, Inc. Coatings for medical devices comprising a therapeutic agent and a metallic material
US8815273B2 (en) 2007-07-27 2014-08-26 Boston Scientific Scimed, Inc. Drug eluting medical devices having porous layers
US8900292B2 (en) 2007-08-03 2014-12-02 Boston Scientific Scimed, Inc. Coating for medical device having increased surface area
US8920491B2 (en) 2008-04-22 2014-12-30 Boston Scientific Scimed, Inc. Medical devices having a coating of inorganic material
US8932346B2 (en) 2008-04-24 2015-01-13 Boston Scientific Scimed, Inc. Medical devices having inorganic particle layers
US9284409B2 (en) 2007-07-19 2016-03-15 Boston Scientific Scimed, Inc. Endoprosthesis having a non-fouling surface

Families Citing this family (524)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5811447A (en) 1993-01-28 1998-09-22 Neorx Corporation Therapeutic inhibitor of vascular smooth muscle cells
US6515009B1 (en) 1991-09-27 2003-02-04 Neorx Corporation Therapeutic inhibitor of vascular smooth muscle cells
US6861571B1 (en) * 1994-11-28 2005-03-01 The Procter & Gamble Company Article having a lotioned topsheet
US7550005B2 (en) * 1995-06-07 2009-06-23 Cook Incorporated Coated implantable medical device
US7070590B1 (en) * 1996-07-02 2006-07-04 Massachusetts Institute Of Technology Microchip drug delivery devices
DE19736520A1 (de) * 1997-08-22 1999-02-25 Lohmann Therapie Syst Lts Kennzeichnung für klebende flächenförmige dermale und transdermale therapeutische Darreichungsformen unter Verwendung eines klebenden Plfasters als Informationsträger, sowie Verfahren zu seiner Herstellung
US6485462B1 (en) 1997-08-27 2002-11-26 Science Incorporated Fluid delivery device with heat activated energy source
US20030036746A1 (en) * 2001-08-16 2003-02-20 Avi Penner Devices for intrabody delivery of molecules and systems and methods utilizing same
CN1089922C (zh) * 1998-01-15 2002-08-28 英业达股份有限公司 动画界面编辑方法
US6610440B1 (en) * 1998-03-10 2003-08-26 Bipolar Technologies, Inc Microscopic batteries for MEMS systems
US7208010B2 (en) 2000-10-16 2007-04-24 Conor Medsystems, Inc. Expandable medical device for delivery of beneficial agent
US6241762B1 (en) 1998-03-30 2001-06-05 Conor Medsystems, Inc. Expandable medical device with ductile hinges
US7179289B2 (en) 1998-03-30 2007-02-20 Conor Medsystems, Inc. Expandable medical device for delivery of beneficial agent
US20040254635A1 (en) 1998-03-30 2004-12-16 Shanley John F. Expandable medical device for delivery of beneficial agent
GB9808052D0 (en) 1998-04-17 1998-06-17 Secr Defence Implants for administering substances and methods of producing implants
US7922709B2 (en) * 1998-07-13 2011-04-12 Genetronics, Inc. Enhanced delivery of naked DNA to skin by non-invasive in vivo electroporation
US6678556B1 (en) * 1998-07-13 2004-01-13 Genetronics, Inc. Electrical field therapy with reduced histopathological change in muscle
US6908770B1 (en) 1998-07-16 2005-06-21 Board Of Regents, The University Of Texas System Fluid based analysis of multiple analytes by a sensor array
US6872187B1 (en) 1998-09-01 2005-03-29 Izex Technologies, Inc. Orthoses for joint rehabilitation
US6376549B1 (en) * 1998-09-17 2002-04-23 Akesis Pharmaceuticals, Inc. Metforimin-containing compositions for the treatment of diabetes
EP1113804A2 (de) * 1998-09-17 2001-07-11 Akesis Pharmaceuticals, Inc. Kombinationen des chroms oder des vanadiums mit antidiabetika für glukosemetabolismusstörungen
US6984404B1 (en) 1998-11-18 2006-01-10 University Of Florida Research Foundation, Inc. Methods for preparing coated drug particles and pharmaceutical formulations thereof
AU2051600A (en) * 1998-12-10 2000-06-26 Board Of Regents, The University Of Texas System Compositions and methods of modulating cholesterol metabolism
US6638727B1 (en) * 1999-01-26 2003-10-28 Cytyc Health Corporation Methods for identifying treating or monitoring asymptomatic patients for risk reduction or therapeutic treatment of breast cancer
US8068897B1 (en) 1999-03-01 2011-11-29 Gazdzinski Robert F Endoscopic smart probe and method
US8636648B2 (en) 1999-03-01 2014-01-28 West View Research, Llc Endoscopic smart probe
US10973397B2 (en) 1999-03-01 2021-04-13 West View Research, Llc Computerized information collection and processing apparatus
US7914442B1 (en) 1999-03-01 2011-03-29 Gazdzinski Robert F Endoscopic smart probe and method
WO2000053301A1 (en) * 1999-03-12 2000-09-14 Microscent, Llc. Methods and apparatus for localized delivery of scented aerosols
US6217895B1 (en) 1999-03-22 2001-04-17 Control Delivery Systems Method for treating and/or preventing retinal diseases with sustained release corticosteroids
EP1754488A1 (de) 1999-05-24 2007-02-21 Introgen Therapeutics, Inc. Verfahren und Zusammensetzungen für nichtvirale Gentherapie zur Behandlung von hyperproliferativen Krankheiten
US6406745B1 (en) * 1999-06-07 2002-06-18 Nanosphere, Inc. Methods for coating particles and particles produced thereby
US7416537B1 (en) 1999-06-23 2008-08-26 Izex Technologies, Inc. Rehabilitative orthoses
SE9902474D0 (sv) * 1999-06-30 1999-06-30 Amersham Pharm Biotech Ab Polymer valves
US6589779B1 (en) 1999-07-16 2003-07-08 Board Of Regents, The University Of Texas System General signaling protocol for chemical receptors in immobilized matrices
US6969382B2 (en) 1999-07-26 2005-11-29 Zuli Holdings, Ltd. Method and apparatus for treating bodily tissues with medicinal substance
US6334859B1 (en) * 1999-07-26 2002-01-01 Zuli Holdings Ltd. Subcutaneous apparatus and subcutaneous method for treating bodily tissues with electricity or medicaments
DE60018582T2 (de) * 1999-08-18 2006-01-19 Microchips, Inc., Bedford Thermisch aktivierbarer microchip als abgabevorrichtung für chemikalien
DE19940242A1 (de) * 1999-08-25 2001-03-01 Lohmann Therapie Syst Lts Verfahren zum Auftragen einer wirkstoffhaltigen Zubereitung in flüssiger Phase auf ein flächenhaftes Substrat im freien Strahl
DE19940241A1 (de) * 1999-08-25 2001-03-01 Lohmann Therapie Syst Lts Verfahren zum Auftragen wenigstens einer Wirkstoffzubereitung auf eine oder beide Seiten eines dünnen, eine Trägerschicht bildenden Substrates
KR100353877B1 (ko) * 1999-08-30 2002-09-26 한국전자통신연구원 미소기전소자형 약물주입 시스템 제조 방법
US6802811B1 (en) 1999-09-17 2004-10-12 Endoluminal Therapeutics, Inc. Sensing, interrogating, storing, telemetering and responding medical implants
GB9924334D0 (en) * 1999-10-15 1999-12-15 Secr Defence Pharmaceutical products and methods of fabrication therefor
US6413245B1 (en) 1999-10-21 2002-07-02 Alcon Universal Ltd. Sub-tenon drug delivery
US6416777B1 (en) 1999-10-21 2002-07-09 Alcon Universal Ltd. Ophthalmic drug delivery device
DE60016271T2 (de) 1999-10-21 2005-12-01 Alcon Inc. Medikamentenzuführvorrichtung
US7943162B2 (en) * 1999-10-21 2011-05-17 Alcon, Inc. Drug delivery device
CA2392006C (en) * 1999-11-17 2011-03-15 Microchips, Inc. Microfabricated devices for the delivery of molecules into a carrier fluid
GB9928511D0 (en) * 1999-12-03 2000-02-02 Secr Defence Brit Orally administrable pharmaceutical product and method of fabrication therefor
EP1688132A3 (de) * 1999-12-10 2009-10-07 Massachussetts Institute of Technology Mikrochip-Arzneistoffverabreichungssysteme und Herstellungsverfahren
EP1235560B1 (de) * 1999-12-10 2006-04-19 Massachusetts Institute Of Technology Mikrochip-arzneistoffverabreichungssysteme und herstellungsverfahren
US6271038B1 (en) 1999-12-15 2001-08-07 Glaxo Wellcome Inc. Methods for high throughout determination and ranking of formulations and solubility
DE60135092D1 (de) 2000-01-31 2008-09-11 Univ Texas Tragbare vorrichtung mit einer sensor-array-anordnung
ES2420279T3 (es) * 2000-03-02 2013-08-23 Microchips, Inc. Dispositivos microfabricados y métodos para almacenamiento y exposición selectiva de productos químicos
EP1132058A1 (de) 2000-03-06 2001-09-12 Advanced Laser Applications Holding S.A. Intravaskuläre Prothese
AU2001253479A1 (en) * 2000-04-13 2001-10-30 Sts Biopolymers, Inc. Targeted therapeutic agent release devices and methods of making and using the same
US6375972B1 (en) * 2000-04-26 2002-04-23 Control Delivery Systems, Inc. Sustained release drug delivery devices, methods of use, and methods of manufacturing thereof
US6592519B1 (en) 2000-04-28 2003-07-15 Medtronic, Inc. Smart microfluidic device with universal coating
US10293056B1 (en) 2000-05-24 2019-05-21 Board Of Regents, The University Of Texas System Methods and compositions for non-viral gene therapy for treatment of hyperproliferative diseases
US6730072B2 (en) 2000-05-30 2004-05-04 Massachusetts Institute Of Technology Methods and devices for sealing microchip reservoir devices
US6540675B2 (en) 2000-06-27 2003-04-01 Rosedale Medical, Inc. Analyte monitor
US6494882B1 (en) * 2000-07-25 2002-12-17 Verimetra, Inc. Cutting instrument having integrated sensors
US20040092860A1 (en) * 2000-07-26 2004-05-13 Dev Nagendu B. Skin and muscle-targeted gene therapy by pulsed electrical field
WO2002013671A2 (en) * 2000-08-14 2002-02-21 Pharmacia Corporation Drug release (delivery system)
AU2002211629A1 (en) * 2000-10-10 2002-04-22 Microchips, Inc. Microchip reservoir devices using wireless transmission of power and data
US6773429B2 (en) 2000-10-11 2004-08-10 Microchips, Inc. Microchip reservoir devices and facilitated corrosion of electrodes
US6764507B2 (en) 2000-10-16 2004-07-20 Conor Medsystems, Inc. Expandable medical device with improved spatial distribution
DE20122506U1 (de) 2000-10-16 2005-12-08 Conor Medsystems, Inc., Menlo Park Ausdehnbare medizinische Vorrichtung zur Abgabe eines nützlichen Agens
US6929636B1 (en) 2000-11-08 2005-08-16 Hewlett-Packard Development Company, L.P. Internal drug dispenser capsule medical device
US6632175B1 (en) 2000-11-08 2003-10-14 Hewlett-Packard Development Company, L.P. Swallowable data recorder capsule medical device
US8372139B2 (en) * 2001-02-14 2013-02-12 Advanced Bio Prosthetic Surfaces, Ltd. In vivo sensor and method of making same
US6946086B2 (en) * 2000-12-01 2005-09-20 Clemson University Chemical compositions comprising crystalline colloidal arrays
WO2002055136A2 (en) * 2000-12-01 2002-07-18 Nephros Therapeutics Inc Intrasvascular drug delivery device and use therefor
DE10061057A1 (de) * 2000-12-08 2002-06-13 Pharmed Holding Gmbh Chip-Systeme zur kontrollierten Emission chemosensorisch wirkender Stoffe
DE10063612C2 (de) * 2000-12-20 2002-11-07 Fraunhofer Ges Forschung Mikrosystem zur Kontrolle der Wirkstoffabgabe aus einem Wirkstoffreservoir sowie Implantat mit Mikrosystem
US6666821B2 (en) 2001-01-08 2003-12-23 Medtronic, Inc. Sensor system
WO2002055058A2 (en) * 2001-01-09 2002-07-18 Microchips, Inc. Flexible microchip devices for ophthalmic and other applications
US6650000B2 (en) * 2001-01-16 2003-11-18 International Business Machines Corporation Apparatus and method for forming a battery in an integrated circuit
GB0102171D0 (en) * 2001-01-27 2001-03-14 Krumme John A drug delivery service
US6749581B2 (en) 2001-02-02 2004-06-15 Medtronic, Inc. Variable infusion rate catheter
US6562000B2 (en) 2001-02-02 2003-05-13 Medtronic, Inc. Single-use therapeutic substance delivery device with infusion rate control
US20040073294A1 (en) * 2002-09-20 2004-04-15 Conor Medsystems, Inc. Method and apparatus for loading a beneficial agent into an expandable medical device
US20040220660A1 (en) * 2001-02-05 2004-11-04 Shanley John F. Bioresorbable stent with beneficial agent reservoirs
US6571125B2 (en) 2001-02-12 2003-05-27 Medtronic, Inc. Drug delivery device
US7181287B2 (en) * 2001-02-13 2007-02-20 Second Sight Medical Products, Inc. Implantable drug delivery device
US6964804B2 (en) * 2001-02-14 2005-11-15 Shipley Company, L.L.C. Micromachined structures made by combined wet and dry etching
US6858220B2 (en) * 2001-02-28 2005-02-22 Second Sight Medical Products, Inc. Implantable microfluidic delivery system using ultra-nanocrystalline diamond coating
US20030060695A1 (en) * 2001-03-07 2003-03-27 Connelly Patrick R. Implantable artificial organ devices
US7771468B2 (en) * 2001-03-16 2010-08-10 Angiotech Biocoatings Corp. Medicated stent having multi-layer polymer coating
US7563255B2 (en) 2001-05-03 2009-07-21 Massachusetts Eye And Ear Infirmary Implantable drug delivery device and use thereof
DE10122839B4 (de) * 2001-05-11 2007-11-29 Qimonda Ag Verfahren zum Vereinzeln von Halbleiterstrukturen sowie zum Vereinzeln vorbereitetes Halbleitersubstrat
WO2002096389A1 (en) * 2001-05-30 2002-12-05 Microchips, Inc. Conformal coated microchip reservoir devices
WO2002099457A1 (en) * 2001-05-31 2002-12-12 Massachusetts Inst Technology Microchip devices with improved reservoir opening
US20040173146A1 (en) * 2001-06-07 2004-09-09 Figueroa Iddys D. Application of a bioactive agent to a delivery substrate
US20040173147A1 (en) * 2001-06-07 2004-09-09 Figueroa Iddys D. Application of a bioactive agent to a delivery substrate
US6962715B2 (en) * 2001-10-24 2005-11-08 Hewlett-Packard Development Company, L.P. Method and dosage form for dispensing a bioactive substance
DE60239868D1 (de) 2001-06-12 2011-06-09 Univ Johns Hopkins Med Reservoirvorrichtung für die intraokulare arzneimittelabgabe
US6730772B2 (en) 2001-06-22 2004-05-04 Venkatram P. Shastri Degradable polymers from derivatized ring-opened epoxides
AU2002345328A1 (en) * 2001-06-27 2003-03-03 Remon Medical Technologies Ltd. Method and device for electrochemical formation of therapeutic species in vivo
JP2005505429A (ja) * 2001-06-28 2005-02-24 マイクロチップス・インコーポレーテッド マイクロチップリザーバデバイスを密閉シーリングするための方法
DE10133870A1 (de) * 2001-07-12 2003-02-06 Chris P Lohmann Ophthalmisches Mittel, Verwendung von EGF zur Behandlung von Dry Eye-Syndrom und Insert zur Verabreichung von EGF am Auge
JP4249611B2 (ja) * 2001-07-23 2009-04-02 アルコン，インコーポレイティド 眼薬剤送致装置
WO2003009774A2 (en) 2001-07-23 2003-02-06 Alcon, Inc. Ophthalmic drug delivery device
US7842083B2 (en) 2001-08-20 2010-11-30 Innovational Holdings, Llc. Expandable medical device with improved spatial distribution
US6663615B1 (en) 2001-09-04 2003-12-16 The Ohio State University Dual stage microvalve and method of use
US20030055360A1 (en) * 2001-09-05 2003-03-20 Zeleznik Matthew A. Minimally invasive sensing system for measuring rigidity of anatomical matter
US7776379B2 (en) * 2001-09-19 2010-08-17 Medlogics Device Corporation Metallic structures incorporating bioactive materials and methods for creating the same
US20030060873A1 (en) * 2001-09-19 2003-03-27 Nanomedical Technologies, Inc. Metallic structures incorporating bioactive materials and methods for creating the same
US6723077B2 (en) * 2001-09-28 2004-04-20 Hewlett-Packard Development Company, L.P. Cutaneous administration system
BR0212951A (pt) 2001-09-28 2004-10-26 Mcneil Ppc Inc Formas de dosagens compósitas
US20040146559A1 (en) * 2002-09-28 2004-07-29 Sowden Harry S. Dosage forms having an inner core and outer shell with different shapes
US7097775B2 (en) 2001-10-26 2006-08-29 Second Sight Medical Products, Inc. Coated microfluidic delivery system
US7020355B2 (en) * 2001-11-02 2006-03-28 Massachusetts Institute Of Technology Switchable surfaces
US20030105409A1 (en) 2001-11-14 2003-06-05 Donoghue John Philip Neurological signal decoding
AU2002353013A1 (en) * 2001-12-03 2003-06-17 Massachusetts Institute Of Technology Microscale lyophilization and drying methods for the stabilization of molecules
TW591267B (en) * 2002-01-11 2004-06-11 Chi Mei Optoelectronics Corp A liquid crystal display device
US7004928B2 (en) 2002-02-08 2006-02-28 Rosedale Medical, Inc. Autonomous, ambulatory analyte monitor or drug delivery device
GB0204381D0 (en) * 2002-02-26 2002-04-10 Mcminn Derek J W Knee prosthesis
US20030171738A1 (en) * 2002-03-06 2003-09-11 Konieczynski David D. Convection-enhanced drug delivery device and method of use
US7108680B2 (en) * 2002-03-06 2006-09-19 Codman & Shurtleff, Inc. Closed-loop drug delivery system
CN1638743B (zh) * 2002-03-11 2012-11-07 爱尔康公司 可植入药物的释放系统
AU2003228711C1 (en) 2002-04-26 2010-01-07 Board Of Regents, The University Of Texas System Method and system for the detection of cardiac risk factors
US8871241B2 (en) 2002-05-07 2014-10-28 Psivida Us, Inc. Injectable sustained release delivery devices
WO2003101532A2 (en) * 2002-06-04 2003-12-11 Cyberkinetics, Inc. Optically-connected implants and related systems and methods of use
US20070265582A1 (en) * 2002-06-12 2007-11-15 University Of Southern California Injection Devices for Unimpeded Target Location Testing
US20030233125A1 (en) * 2002-06-12 2003-12-18 Alfred E. Mann Institute For Biomedical Engineering At The University Of S. California Injection devices for unimpeded target location testing
PT1521573E (pt) * 2002-07-15 2008-02-08 Alcon Inc Composições de implantes farmacêuticos lipofílicos não poliméricos para utilização intra-ocular
US20070184089A1 (en) * 2002-07-15 2007-08-09 Alcon, Inc. Non-Polymeric Lipophilic Pharmaceutical Implant Compositions for Intraocular Use
US6953455B2 (en) * 2002-07-30 2005-10-11 Hospira, Inc. Medicine delivery system
CA2495327C (en) * 2002-08-16 2008-10-21 Microchips, Inc. Controlled release device and method using electrothermal ablation
AU2007200736B2 (en) * 2002-08-16 2008-09-18 Microchips, Inc. Controlled release device and method
JP3887588B2 (ja) * 2002-08-30 2007-02-28 株式会社リガク Ｘ線回折による応力測定法
WO2004022033A1 (en) * 2002-09-04 2004-03-18 Microchips, Inc. Method and device for the controlled delivery of parathyroid hormone
US7758636B2 (en) 2002-09-20 2010-07-20 Innovational Holdings Llc Expandable medical device with openings for delivery of multiple beneficial agents
CA2499594A1 (en) * 2002-09-20 2004-04-01 Conor Medsystems, Inc. Expandable medical device with openings for delivery of multiple beneficial agents
AU2003278881A1 (en) * 2002-09-23 2004-04-08 Microchips, Inc. Micro-reservoir osmotic release systems and microtube array device
US20060100695A1 (en) * 2002-09-27 2006-05-11 Peacock James C Iii Implantable stent with modified ends
US7807197B2 (en) * 2002-09-28 2010-10-05 Mcneil-Ppc, Inc. Composite dosage forms having an inlaid portion
WO2004033034A1 (en) 2002-10-04 2004-04-22 Microchips, Inc. Medical device for neural stimulation and controlled drug delivery
DE60331455D1 (de) * 2002-10-04 2010-04-08 Microchips Inc Medizinische vorrichtung zur gesteuerten arzneimittelverabreichung sowie herzüberwachung und/oder herzstimulation
US6800663B2 (en) * 2002-10-18 2004-10-05 Alkermes Controlled Therapeutics Inc. Ii, Crosslinked hydrogel copolymers
US7212851B2 (en) * 2002-10-24 2007-05-01 Brown University Research Foundation Microstructured arrays for cortex interaction and related methods of manufacture and use
US7087017B2 (en) * 2002-10-31 2006-08-08 Medtronic, Inc. Atraumatic sensor lead assemblies
IL152629A (en) * 2002-11-04 2010-12-30 Innoventions Ltd Implantable medical device for controlled release of a substance
PL376752A1 (pl) 2002-11-07 2006-01-09 Abbott Laboratories Proteza o zmiennym stężeniu korzystnego środka
US8524148B2 (en) 2002-11-07 2013-09-03 Abbott Laboratories Method of integrating therapeutic agent into a bioerodible medical device
US8221495B2 (en) 2002-11-07 2012-07-17 Abbott Laboratories Integration of therapeutic agent into a bioerodible medical device
US6902544B2 (en) * 2003-01-22 2005-06-07 Codman & Shurtleff, Inc. Troubleshooting accelerator system for implantable drug delivery pumps
US7483750B2 (en) * 2003-03-21 2009-01-27 Second Sight Medical Products, Inc. Transretinal implant and method of implantation
US7052652B2 (en) 2003-03-24 2006-05-30 Rosedale Medical, Inc. Analyte concentration detection devices and methods
EP1610823B1 (de) 2003-03-28 2011-09-28 Innovational Holdings, LLC Implantierbares medizinprodukt mit kontinuierlichem mittel-konzentrationsgefälle
DE10315538A1 (de) * 2003-04-04 2004-10-21 Siemens Ag Teilchen mit einer Membran
AU2004233869B2 (en) * 2003-04-25 2010-08-12 Boston Scientific Scimed, Inc. Solid drug formulation and device for storage and controlled delivery thereof
US20040220531A1 (en) * 2003-05-01 2004-11-04 Bui Tuan S. System and method operating microreservoirs delivering medication in coordination with a pump delivering diluent
US7051654B2 (en) * 2003-05-30 2006-05-30 Clemson University Ink-jet printing of viable cells
US7169179B2 (en) * 2003-06-05 2007-01-30 Conor Medsystems, Inc. Drug delivery device and method for bi-directional drug delivery
US7442180B2 (en) * 2003-06-10 2008-10-28 Hewlett-Packard Development Company, L.P. Apparatus and methods for administering bioactive compositions
US7819847B2 (en) * 2003-06-10 2010-10-26 Hewlett-Packard Development Company, L.P. System and methods for administering bioactive compositions
US7226441B2 (en) * 2003-06-23 2007-06-05 Codman & Shurtleff, Inc. Catheter with block-overriding system
JP2007526019A (ja) * 2003-07-10 2007-09-13 アルコン，インコーポレイティド 眼科用薬物送達デバイス
US7114312B2 (en) * 2003-07-17 2006-10-03 Microchips, Inc. Low temperature methods for hermetically sealing reservoir devices
US20050055014A1 (en) * 2003-08-04 2005-03-10 Coppeta Jonathan R. Methods for accelerated release of material from a reservoir device
NZ580449A (en) 2003-09-11 2011-06-30 Theranos Inc Ingestible medical device with biocompatible polymer coating, device with microarray to interact with disease marker
US7785653B2 (en) * 2003-09-22 2010-08-31 Innovational Holdings Llc Method and apparatus for loading a beneficial agent into an expandable medical device
AU2004285603A1 (en) * 2003-11-03 2005-05-12 Microchips, Inc. Medical device for sensing glucose
US7208172B2 (en) * 2003-11-03 2007-04-24 Medlogics Device Corporation Metallic composite coating for delivery of therapeutic agents from the surface of implantable devices
US20050143589A1 (en) * 2003-11-09 2005-06-30 Donoghue John P. Calibration systems and methods for neural interface devices
US20050113744A1 (en) * 2003-11-21 2005-05-26 Cyberkinetics, Inc. Agent delivery systems and related methods under control of biological electrical signals
US7751877B2 (en) * 2003-11-25 2010-07-06 Braingate Co., Llc Neural interface system with embedded id
US20060085062A1 (en) * 2003-11-28 2006-04-20 Medlogics Device Corporation Implantable stent with endothelialization factor
US20050119723A1 (en) * 2003-11-28 2005-06-02 Medlogics Device Corporation Medical device with porous surface containing bioerodable bioactive composites and related methods
US7651868B2 (en) * 2003-12-11 2010-01-26 The Board Of Regents Of The University Of Texas System Method and system for the analysis of saliva using a sensor array
US7647097B2 (en) * 2003-12-29 2010-01-12 Braingate Co., Llc Transcutaneous implant
JP2007521928A (ja) * 2004-02-13 2007-08-09 コナー　メドシステムズ，　インコーポレイテッド ワイヤフィラメントを含む埋め込み可能薬剤送出デバイス
US7364564B2 (en) * 2004-03-02 2008-04-29 Becton, Dickinson And Company Implant having MEMS flow module with movable, flow-controlling baffle
US7548092B2 (en) 2004-02-25 2009-06-16 Ternarylogic Llc Implementing logic functions with non-magnitude based physical phenomena
US7696785B2 (en) * 2004-02-25 2010-04-13 Ternarylogic Llc Implementing logic functions with non-magnitude based physical phenomena
US7563460B2 (en) * 2004-02-26 2009-07-21 Med Five, Inc. Enteric coated oral pharmaceutical to erode kidney stones
US8105849B2 (en) 2004-02-27 2012-01-31 Board Of Regents, The University Of Texas System Integration of fluids and reagents into self-contained cartridges containing sensor elements
US8101431B2 (en) 2004-02-27 2012-01-24 Board Of Regents, The University Of Texas System Integration of fluids and reagents into self-contained cartridges containing sensor elements and reagent delivery systems
US20050203366A1 (en) * 2004-03-12 2005-09-15 Donoghue John P. Neurological event monitoring and therapy systems and related methods
WO2008035343A2 (en) * 2006-09-21 2008-03-27 Technion Research & Development Foundation Ltd. Artificial receptors
US8354066B2 (en) 2004-03-24 2013-01-15 Technion Research & Development Foundation Ltd. Artificial receptors
US20070036835A1 (en) * 2004-07-19 2007-02-15 Microchips, Inc. Hermetically Sealed Devices for Controlled Release or Exposure of Reservoir Contents
US7537590B2 (en) * 2004-07-30 2009-05-26 Microchips, Inc. Multi-reservoir device for transdermal drug delivery and sensing
US20060049957A1 (en) * 2004-08-13 2006-03-09 Surgenor Timothy R Biological interface systems with controlled device selector and related methods
US20060039949A1 (en) * 2004-08-20 2006-02-23 Nycz Jeffrey H Acetabular cup with controlled release of an osteoinductive formulation
WO2006026768A1 (en) * 2004-09-01 2006-03-09 Microchips, Inc. Multi-cap reservoir devices for controlled release or exposure of reservoir contents
US20100164548A1 (en) * 2004-09-08 2010-07-01 Ternarylogic Llc Implementing Logic Functions With Non-Magnitude Based Physical Phenomena
US8271093B2 (en) 2004-09-17 2012-09-18 Cardiac Pacemakers, Inc. Systems and methods for deriving relative physiologic measurements using a backend computing system
GB2418144A (en) * 2004-09-17 2006-03-22 Psimedica Ltd Medical device for delivery of beneficial substance
US8560041B2 (en) 2004-10-04 2013-10-15 Braingate Co., Llc Biological interface system
DE102004050457A1 (de) * 2004-10-12 2006-04-13 Capsulution Nanoscience Ag Segmentierte Vorrichtung für die verzögerte Freisetzung von Molekülen in tangentialer Richtung durch dünne Filme und Anwendungen derselben
AU2005295472B2 (en) * 2004-10-14 2011-11-10 Trustees Of Tufts College Electrochemically degradable polymers
EP1812090A1 (de) * 2004-10-28 2007-08-01 Microchips, Inc. Orthopädische und dentale implantate mit kontrollierter arzneimittelfreisetzung
JP5049787B2 (ja) 2004-11-04 2012-10-17 マイクロチップス・インコーポレーテッド 冷間圧接封止法および装置
WO2006055547A2 (en) 2004-11-15 2006-05-26 Izex Technologies, Inc. Instrumented orthopedic and other medical implants
US8308794B2 (en) 2004-11-15 2012-11-13 IZEK Technologies, Inc. Instrumented implantable stents, vascular grafts and other medical devices
US7413846B2 (en) * 2004-11-15 2008-08-19 Microchips, Inc. Fabrication methods and structures for micro-reservoir devices
US7813808B1 (en) 2004-11-24 2010-10-12 Remon Medical Technologies Ltd Implanted sensor system with optimized operational and sensing parameters
US7991461B2 (en) * 2005-01-06 2011-08-02 Braingate Co., Llc Patient training routine for biological interface system
US8095209B2 (en) * 2005-01-06 2012-01-10 Braingate Co., Llc Biological interface system with gated control signal
WO2006074029A2 (en) 2005-01-06 2006-07-13 Cyberkinetics Neurotechnology Systems, Inc. Neurally controlled and multi-device patient ambulation systems and related methods
US20060167564A1 (en) * 2005-01-10 2006-07-27 Flaherty J C Limb and digit movement system
US8812096B2 (en) * 2005-01-10 2014-08-19 Braingate Co., Llc Biological interface system with patient training apparatus
US8128952B2 (en) * 2005-01-12 2012-03-06 Clemson University Research Foundation Ligand-mediated controlled drug delivery
US7881780B2 (en) * 2005-01-18 2011-02-01 Braingate Co., Llc Biological interface system with thresholded configuration
US20080076975A1 (en) * 2005-01-25 2008-03-27 Microchips, Inc. Method and implantable device with reservoir array for pre-clinical in vivo testing
US7488316B2 (en) 2005-01-25 2009-02-10 Microchips, Inc. Control of drug release by transient modification of local microenvironments
WO2006086391A2 (en) * 2005-02-07 2006-08-17 Massachusetts Institute Of Technology Electrochemically-degradable layer-by-layer thin films
US20100001104A1 (en) * 2005-03-29 2010-01-07 Waterbury Companies, Inc. Precision release vaporization device
US20100204551A1 (en) * 2008-10-22 2010-08-12 Martin William Roche Detection, Prevention and Treatment of Infections in Implantable Devices
US7584907B2 (en) 2005-03-29 2009-09-08 Contadini Carl D Precision release aerosol device
US20070066138A1 (en) * 2005-04-05 2007-03-22 The Ohio State University Research Foundation Diffusion Delivery Systems and Methods of Fabrication
US20060226575A1 (en) * 2005-04-07 2006-10-12 Mariam Maghribi Micro-fabrication of bio-degradable polymeric implants
US8673352B2 (en) 2005-04-15 2014-03-18 Mcneil-Ppc, Inc. Modified release dosage form
KR101381331B1 (ko) 2005-05-09 2014-04-04 테라노스, 인코포레이티드 현장진료 유체 시스템 및 그 용도
US8377398B2 (en) 2005-05-31 2013-02-19 The Board Of Regents Of The University Of Texas System Methods and compositions related to determination and use of white blood cell counts
US8309057B2 (en) * 2005-06-10 2012-11-13 The Invention Science Fund I, Llc Methods for elevating neurotrophic agents
US20060281187A1 (en) 2005-06-13 2006-12-14 Rosedale Medical, Inc. Analyte detection devices and methods with hematocrit/volume correction and feedback control
US20070016163A1 (en) * 2005-06-28 2007-01-18 Microchips, Inc. Medical and dental implant devices for controlled drug delivery
EP1904148A2 (de) * 2005-07-05 2008-04-02 Koninklijke Philips Electronics N.V. Vorrichtung zur kontrollierten freigabe einer vordefinierten menge einer substanz
DK1933810T3 (da) * 2005-08-11 2013-01-28 Childrens Medical Center Intravesikal lægemiddelafgivelsesindretning og fremgangsmåde
US20070055352A1 (en) * 2005-09-07 2007-03-08 Wendy Naimark Stent with pockets for containing a therapeutic agent
US7742815B2 (en) 2005-09-09 2010-06-22 Cardiac Pacemakers, Inc. Using implanted sensors for feedback control of implanted medical devices
US8801631B2 (en) 2005-09-30 2014-08-12 Intuity Medical, Inc. Devices and methods for facilitating fluid transport
WO2007041244A2 (en) 2005-09-30 2007-04-12 Intuity Medical, Inc. Multi-site body fluid sampling and analysis cartridge
US8168584B2 (en) 2005-10-08 2012-05-01 Potentia Pharmaceuticals, Inc. Methods of treating age-related macular degeneration by compstatin and analogs thereof
EP1937139A2 (de) * 2005-10-11 2008-07-02 Koninklijke Philips Electronics N.V. Einzeln aktivierte sensoren für implantierbare vorrichtungen
US20070088442A1 (en) * 2005-10-14 2007-04-19 Microchips, Inc. Passive wear-indicating sensor for implantable prosthetic device
US20070106143A1 (en) * 2005-11-08 2007-05-10 Flaherty J C Electrode arrays and related methods
US8882747B2 (en) 2005-11-09 2014-11-11 The Invention Science Fund I, Llc Substance delivery system
US8083710B2 (en) * 2006-03-09 2011-12-27 The Invention Science Fund I, Llc Acoustically controlled substance delivery device
US8992511B2 (en) 2005-11-09 2015-03-31 The Invention Science Fund I, Llc Acoustically controlled substance delivery device
US8936590B2 (en) * 2005-11-09 2015-01-20 The Invention Science Fund I, Llc Acoustically controlled reaction device
US8273071B2 (en) 2006-01-18 2012-09-25 The Invention Science Fund I, Llc Remote controller for substance delivery system
US8998884B2 (en) * 2005-11-09 2015-04-07 The Invention Science Fund I, Llc Remote controlled in situ reaction method
US9067047B2 (en) 2005-11-09 2015-06-30 The Invention Science Fund I, Llc Injectable controlled release fluid delivery system
US9028467B2 (en) 2005-11-09 2015-05-12 The Invention Science Fund I, Llc Osmotic pump with remotely controlled osmotic pressure generation
US20070112421A1 (en) * 2005-11-14 2007-05-17 O'brien Barry Medical device with a grooved surface
US20070156126A1 (en) * 2005-12-29 2007-07-05 Flaherty J C Medical device insertion system and related methods
US20100023021A1 (en) * 2005-12-27 2010-01-28 Flaherty J Christopher Biological Interface and Insertion
US8840660B2 (en) 2006-01-05 2014-09-23 Boston Scientific Scimed, Inc. Bioerodible endoprostheses and methods of making the same
US8089029B2 (en) 2006-02-01 2012-01-03 Boston Scientific Scimed, Inc. Bioabsorbable metal medical device and method of manufacture
WO2007092735A2 (en) 2006-02-02 2007-08-16 Innovative Bio Therapies An extracorporeal cell-based therapeutic device and delivery system
WO2007092944A2 (en) * 2006-02-08 2007-08-16 Introgen Therapeutics, Inc. Compositions and methods involving gene therapy and proteasome modulation
US20070191816A1 (en) * 2006-02-13 2007-08-16 Boston Scientific Scimed, Inc. Radio frequency induced drug elution
US20080140057A1 (en) * 2006-03-09 2008-06-12 Searete Llc, A Limited Liability Corporation Of State Of The Delaware Injectable controlled release fluid delivery system
US20070239256A1 (en) * 2006-03-22 2007-10-11 Jan Weber Medical devices having electrical circuits with multilayer regions
US11287421B2 (en) 2006-03-24 2022-03-29 Labrador Diagnostics Llc Systems and methods of sample processing and fluid control in a fluidic system
US8741230B2 (en) 2006-03-24 2014-06-03 Theranos, Inc. Systems and methods of sample processing and fluid control in a fluidic system
US8048150B2 (en) 2006-04-12 2011-11-01 Boston Scientific Scimed, Inc. Endoprosthesis having a fiber meshwork disposed thereon
CA2650140A1 (en) 2006-04-14 2007-10-25 Mriganka Sur Identifying and modulating molecular pathways that mediate nervous system plasticity
WO2007129240A1 (en) * 2006-05-05 2007-11-15 Koninklijke Philips Electronics N. V. Device and method for the controlled release of a predefined quantity of a substance
US8007999B2 (en) 2006-05-10 2011-08-30 Theranos, Inc. Real-time detection of influenza virus
US20070275035A1 (en) * 2006-05-24 2007-11-29 Microchips, Inc. Minimally Invasive Medical Implant Devices for Controlled Drug Delivery
US7803148B2 (en) * 2006-06-09 2010-09-28 Neurosystec Corporation Flow-induced delivery from a drug mass
EP1867990A1 (de) * 2006-06-14 2007-12-19 Koninklijke Philips Electronics N.V. Sensitiver Test mittels Verstärkung eines Etikettsignals
EP2035075A1 (de) * 2006-06-20 2009-03-18 Koninklijke Philips Electronics N.V. Elektronische kapsel zur behandlung von magen-darm-erkrankungen
US20080015494A1 (en) * 2006-07-11 2008-01-17 Microchips, Inc. Multi-reservoir pump device for dialysis, biosensing, or delivery of substances
US20150005720A1 (en) * 2006-07-18 2015-01-01 E Ink California, Llc Electrophoretic display
US7955268B2 (en) 2006-07-21 2011-06-07 Cardiac Pacemakers, Inc. Multiple sensor deployment
EP2054537A2 (de) 2006-08-02 2009-05-06 Boston Scientific Scimed, Inc. Endoprothese mit dreidimensionaler desintegrationssteuerung
US20080033260A1 (en) * 2006-08-03 2008-02-07 Microchips, Inc. Cardiac Biosensor Devices and Methods
US9481912B2 (en) 2006-09-12 2016-11-01 Longhorn Vaccines And Diagnostics, Llc Compositions and methods for detecting and identifying nucleic acid sequences in biological samples
US8080645B2 (en) 2007-10-01 2011-12-20 Longhorn Vaccines & Diagnostics Llc Biological specimen collection/transport compositions and methods
US8097419B2 (en) 2006-09-12 2012-01-17 Longhorn Vaccines & Diagnostics Llc Compositions and method for rapid, real-time detection of influenza A virus (H1N1) swine 2009
WO2008034031A2 (en) 2006-09-15 2008-03-20 Boston Scientific Limited Bioerodible endoprostheses and methods of making the same
JP2010503494A (ja) 2006-09-15 2010-02-04 ボストン サイエンティフィック リミテッド 生分解性内部人工器官およびその製造方法
WO2008034048A2 (en) 2006-09-15 2008-03-20 Boston Scientific Limited Bioerodible endoprosthesis with biostable inorganic layers
CA2663220A1 (en) 2006-09-15 2008-03-20 Boston Scientific Limited Medical devices and methods of making the same
EP2068962B1 (de) 2006-09-18 2013-01-30 Boston Scientific Limited Endoprothesen
US8012744B2 (en) 2006-10-13 2011-09-06 Theranos, Inc. Reducing optical interference in a fluidic device
US20080113391A1 (en) 2006-11-14 2008-05-15 Ian Gibbons Detection and quantification of analytes in bodily fluids
DE602007011822D1 (de) * 2006-11-16 2011-02-17 Boston Scient Ltd Stent mit funktion zur zu unterschiedlichen zeiten erfolgenden abluminalen und luminalen freisetzung eines behandlungsmittels
ES2506144T3 (es) 2006-12-28 2014-10-13 Boston Scientific Limited Endoprótesis bioerosionables y procedimiento de fabricación de las mismas
AU2008214359B2 (en) 2007-02-05 2014-01-16 Apellis Pharmaceuticals, Inc. Local complement inhibition for treatment of complement-mediated disorders
US8445267B2 (en) 2007-04-09 2013-05-21 University Of Florida Research Foundation, Inc. Tyrosine-modified recombinant rAAV vector compositions and methods for use
WO2008154416A2 (en) 2007-06-07 2008-12-18 Microchips, Inc. Electrochemical biosensors and arrays
WO2008157372A2 (en) 2007-06-14 2008-12-24 Massachusetts Institute Of Technology Self assembled films for protein and drug delivery applications
DE102007031549B4 (de) * 2007-07-06 2021-07-08 Robert Bosch Gmbh Vorrichtung aus einkristallinem Silizium und Verfahren zur Herstellung einer Vorrichtung aus einkristallinem Silizium
DE102007032688A1 (de) * 2007-07-13 2009-01-22 Biotronik Vi Patent Ag Implantat und System aus einem Implantat und einer Anregungsvorrichtung
US8158430B1 (en) 2007-08-06 2012-04-17 Theranos, Inc. Systems and methods of fluidic sample processing
SG183726A1 (en) 2007-08-14 2012-09-27 Hutchinson Fred Cancer Res Needle array assembly and method for delivering therapeutic agents
US8702640B2 (en) 2007-08-17 2014-04-22 The Invention Science Fund I, Llc System, devices, and methods including catheters configured to monitor and inhibit biofilm formation
US8734718B2 (en) 2007-08-17 2014-05-27 The Invention Science Fund I, Llc Systems, devices, and methods including catheters having an actively controllable therapeutic agent delivery component
US8753304B2 (en) 2007-08-17 2014-06-17 The Invention Science Fund I, Llc Systems, devices, and methods including catheters having acoustically actuatable waveguide components for delivering a sterilizing stimulus to a region proximate a surface of the catheter
US8706211B2 (en) * 2007-08-17 2014-04-22 The Invention Science Fund I, Llc Systems, devices, and methods including catheters having self-cleaning surfaces
US8366652B2 (en) 2007-08-17 2013-02-05 The Invention Science Fund I, Llc Systems, devices, and methods including infection-fighting and monitoring shunts
US11041215B2 (en) 2007-08-24 2021-06-22 Longhorn Vaccines And Diagnostics, Llc PCR ready compositions and methods for detecting and identifying nucleic acid sequences
US9683256B2 (en) 2007-10-01 2017-06-20 Longhorn Vaccines And Diagnostics, Llc Biological specimen collection and transport system
US10004799B2 (en) 2007-08-27 2018-06-26 Longhorn Vaccines And Diagnostics, Llc Composite antigenic sequences and vaccines
US8821885B2 (en) 2007-08-27 2014-09-02 Longhorn Vaccines & Diagnostics, Llc Immunogenic compositions and methods
US8052745B2 (en) 2007-09-13 2011-11-08 Boston Scientific Scimed, Inc. Endoprosthesis
US20090076591A1 (en) * 2007-09-19 2009-03-19 Boston Scientific Scimed, Inc. Stent Design Allowing Extended Release of Drug and/or Enhanced Adhesion of Polymer to OD Surface
EP2052700A1 (de) 2007-09-26 2009-04-29 Microchips, Inc. Arzneimittelverabreichungsvorrichtung und Verfahren zur Verwendung mit Prothesenimplantaten.
US11041216B2 (en) 2007-10-01 2021-06-22 Longhorn Vaccines And Diagnostics, Llc Compositions and methods for detecting and quantifying nucleic acid sequences in blood samples
EP2535428B1 (de) 2007-10-01 2015-09-09 Longhorn Vaccines and Diagnostics, LLC System zum Sammeln und Transportieren biologischer Proben sowie Verfahren zu seiner Verwendung
CN103323610B (zh) 2007-10-02 2016-12-28 赛拉诺斯股份有限公司 模块化现场护理装置及其应用
US8303573B2 (en) * 2007-10-17 2012-11-06 The Invention Science Fund I, Llc Medical or veterinary digestive tract utilization systems and methods
US8789536B2 (en) * 2007-10-17 2014-07-29 The Invention Science Fund I, Llc Medical or veterinary digestive tract utilization systems and methods
US20090105561A1 (en) * 2007-10-17 2009-04-23 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Medical or veterinary digestive tract utilization systems and methods
US8707964B2 (en) * 2007-10-31 2014-04-29 The Invention Science Fund I, Llc Medical or veterinary digestive tract utilization systems and methods
US8808276B2 (en) * 2007-10-23 2014-08-19 The Invention Science Fund I, Llc Adaptive dispensation in a digestive tract
US20090112315A1 (en) * 2007-10-29 2009-04-30 Zimmer, Inc. Medical implants and methods for delivering biologically active agents
US8333754B2 (en) * 2007-10-31 2012-12-18 The Invention Science Fund I, Llc Medical or veterinary digestive tract utilization systems and methods
US20090163894A1 (en) * 2007-10-31 2009-06-25 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Medical or veterinary digestive tract utilization systems and methods
US8808271B2 (en) * 2007-10-31 2014-08-19 The Invention Science Fund I, Llc Medical or veterinary digestive tract utilization systems and methods
US8109920B2 (en) * 2007-10-31 2012-02-07 The Invention Science Fund I, Llc Medical or veterinary digestive tract utilization systems and methods
US20090137866A1 (en) * 2007-11-28 2009-05-28 Searete Llc, A Limited Liability Corporation Of The State Delaware Medical or veterinary digestive tract utilization systems and methods
US7833266B2 (en) 2007-11-28 2010-11-16 Boston Scientific Scimed, Inc. Bifurcated stent with drug wells for specific ostial, carina, and side branch treatment
US8989858B2 (en) 2007-12-05 2015-03-24 The Invention Science Fund I, Llc Implant system for chemical modulation of neural activity
US8165668B2 (en) 2007-12-05 2012-04-24 The Invention Science Fund I, Llc Method for magnetic modulation of neural conduction
US8180447B2 (en) 2007-12-05 2012-05-15 The Invention Science Fund I, Llc Method for reversible chemical modulation of neural activity
US8195287B2 (en) 2007-12-05 2012-06-05 The Invention Science Fund I, Llc Method for electrical modulation of neural conduction
US8165669B2 (en) 2007-12-05 2012-04-24 The Invention Science Fund I, Llc System for magnetic modulation of neural conduction
US8180446B2 (en) 2007-12-05 2012-05-15 The Invention Science Fund I, Llc Method and system for cyclical neural modulation based on activity state
US8170659B2 (en) 2007-12-05 2012-05-01 The Invention Science Fund I, Llc Method for thermal modulation of neural activity
US8170658B2 (en) 2007-12-05 2012-05-01 The Invention Science Fund I, Llc System for electrical modulation of neural conduction
CN101896221B (zh) 2007-12-11 2013-06-05 麻省理工学院 用于治疗膀胱和其它体囊或体腔的可植入式药物递送设备和方法
US7722661B2 (en) * 2007-12-19 2010-05-25 Boston Scientific Scimed, Inc. Stent
EP2247269B1 (de) * 2008-01-24 2011-08-24 Boston Scientific Scimed, Inc. Stent zum ausbringen eines therapeutischen mittels von einer seitenfläche einer stentstrebe
US8521273B2 (en) 2008-01-29 2013-08-27 Gilbert H. KLIMAN Drug delivery devices, kits and methods therefor
US20090198321A1 (en) * 2008-02-01 2009-08-06 Boston Scientific Scimed, Inc. Drug-Coated Medical Devices for Differential Drug Release
EP2242538B1 (de) 2008-02-11 2016-04-06 Cardiac Pacemakers, Inc. Verfahren zur überwachung eines hämodynamischen status für herzrhythmusunterscheidungen
WO2009102640A1 (en) 2008-02-12 2009-08-20 Cardiac Pacemakers, Inc. Systems and methods for controlling wireless signal transfers between ultrasound-enabled medical devices
US7981106B2 (en) * 2008-02-26 2011-07-19 Pinchas Gilad Electronically-controlled device for release of drugs, proteins, and other organic or inorganic chemicals
US20090270795A1 (en) * 2008-04-23 2009-10-29 Medtronic, Inc. Method for welding a barrier in an implantable drug delivery device
US7998192B2 (en) 2008-05-09 2011-08-16 Boston Scientific Scimed, Inc. Endoprostheses
EP2293719B1 (de) 2008-05-30 2015-09-09 Intuity Medical, Inc. Schnittstelle zwischen einer Vorrichtung zur entnahme von Körperflüssigkeitsproben und der Entnahmestelle
CA2726067C (en) 2008-06-06 2020-10-20 Intuity Medical, Inc. Detection meter and mode of operation
US10383556B2 (en) 2008-06-06 2019-08-20 Intuity Medical, Inc. Medical diagnostic devices and methods
US8236046B2 (en) 2008-06-10 2012-08-07 Boston Scientific Scimed, Inc. Bioerodible endoprosthesis
CA2728215A1 (en) 2008-06-18 2010-06-24 Innovative Biotherapies, Inc. Methods for enhanced propagation of cells
US7951193B2 (en) 2008-07-23 2011-05-31 Boston Scientific Scimed, Inc. Drug-eluting stent
US20100061976A1 (en) * 2008-07-24 2010-03-11 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Method for treating or preventing osteoporosis by reducing follicle stimulating hormone to cyclic physiological levels in a mammalian subject
US20100022487A1 (en) * 2008-07-24 2010-01-28 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Method, device, and kit for maintaining physiological levels of steroid hormone in a subject
US20100022494A1 (en) * 2008-07-24 2010-01-28 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Method, device, and kit for maintaining physiological levels of steroid hormone in a subject
US20100022497A1 (en) * 2008-07-24 2010-01-28 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Method for treating or preventing a cardiovascular disease or condition utilizing estrogen receptor modulators based on APOE allelic profile of a mammalian subject
US7985252B2 (en) 2008-07-30 2011-07-26 Boston Scientific Scimed, Inc. Bioerodible endoprosthesis
US20100028403A1 (en) * 2008-07-31 2010-02-04 Boston Scientific Scimed, Inc. Medical devices for therapeutic agent delivery
BRPI0917135A2 (pt) * 2008-08-09 2015-11-10 Massachusetts Inst Technology dispositivo médico para extensão e retenção em uma vesícula seminal, duto ejaculatório, próstata ou vaso deferente de um paciente, uso de um elastômero reabsorvível, e, dispositivo de bomba osmótica.
WO2010021973A2 (en) * 2008-08-17 2010-02-25 Massachusetts Institute Of Technology Controlled delivery of bioactive agents from decomposable films
US20100068254A1 (en) * 2008-09-16 2010-03-18 Mahalaxmi Gita Bangera Modifying a medicament availability state of a final dosage form
US20100068233A1 (en) * 2008-09-16 2010-03-18 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Modifiable dosage form
US20100069821A1 (en) * 2008-09-16 2010-03-18 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Ex vivo modifiable medicament release-sites final dosage form
US20100068275A1 (en) * 2008-09-16 2010-03-18 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Personalizable dosage form
US20100068278A1 (en) * 2008-09-16 2010-03-18 Searete Llc, A Limited Liablity Corporation Of The State Of Delaware Ex vivo modifiable medicament release-associations
US20100068153A1 (en) * 2008-09-16 2010-03-18 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Ex vivo activatable final dosage form
US20100068235A1 (en) * 2008-09-16 2010-03-18 Searete LLC, a limited liability corporation of Deleware Individualizable dosage form
US20100068152A1 (en) * 2008-09-16 2010-03-18 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Ex vivo modifiable particle or polymeric based final dosage form
US8382824B2 (en) 2008-10-03 2013-02-26 Boston Scientific Scimed, Inc. Medical implant having NANO-crystal grains with barrier layers of metal nitrides or fluorides
US8591423B2 (en) 2008-10-10 2013-11-26 Cardiac Pacemakers, Inc. Systems and methods for determining cardiac output using pulmonary artery pressure measurements
US20100118316A1 (en) * 2008-11-13 2010-05-13 Tokyo Electron Limited Auto focus array detector optimized for operating objectives
WO2010059291A1 (en) 2008-11-19 2010-05-27 Cardiac Pacemakers, Inc. Assessment of pulmonary vascular resistance via pulmonary artery pressure
WO2010065135A1 (en) 2008-12-04 2010-06-10 Searete, Llc System, devices, and methods including actively-controllable sterilizing excitation delivery implants
US20110208023A1 (en) * 2008-12-04 2011-08-25 Goodall Eleanor V Systems, devices, and methods including implantable devices with anti-microbial properties
US20110208021A1 (en) * 2008-12-04 2011-08-25 Goodall Eleanor V Systems, devices, and methods including implantable devices with anti-microbial properties
US20120041285A1 (en) 2008-12-04 2012-02-16 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Systems, devices, and methods including implantable devices with anti-microbial properties
US20110208026A1 (en) * 2008-12-04 2011-08-25 Goodall Eleanor V Systems, devices, and methods including implantable devices with anti-microbial properties
WO2010088548A1 (en) 2009-01-29 2010-08-05 Forsight Labs, Llc Posterior segment drug delivery
US8623395B2 (en) 2010-01-29 2014-01-07 Forsight Vision4, Inc. Implantable therapeutic device
US8317737B2 (en) * 2009-02-25 2012-11-27 The Invention Science Fund I, Llc Device for actively removing a target component from blood or lymph of a vertebrate subject
US8167871B2 (en) 2009-02-25 2012-05-01 The Invention Science Fund I, Llc Device for actively removing a target cell from blood or lymph of a vertebrate subject
WO2010101901A2 (en) 2009-03-02 2010-09-10 Boston Scientific Scimed, Inc. Self-buffering medical implants
WO2010110919A1 (en) 2009-03-26 2010-09-30 Seventh Sense Biosystems, Inc. Monitoring of implants and other devices
EP2411055A2 (de) * 2009-03-26 2012-02-01 Seventh Sense Biosystems, Inc. Bestimmung von tracern in personen
FR2945097B1 (fr) * 2009-04-30 2011-06-03 Commissariat Energie Atomique Vanne microfluidique a usage unique.
CN103494765A (zh) * 2009-05-04 2014-01-08 普西维达公司 多孔硅药物洗脱颗粒
US8632511B2 (en) 2009-05-06 2014-01-21 Alcon Research, Ltd. Multiple thermal sensors in a multiple processor environment for temperature control in a drug delivery device
WO2010135714A2 (en) 2009-05-22 2010-11-25 The Methodist Hospital Research Institute Methods for modulating adipocyte expression using microrna compositions
US8734809B2 (en) 2009-05-28 2014-05-27 University Of Massachusetts AAV's and uses thereof
TW201043224A (en) * 2009-06-06 2010-12-16 Univ Nat Taiwan Drug delivery chip and fabricating method thereof
DK2445571T3 (da) 2009-06-26 2013-02-25 Taris Biomedical Inc Faste lægemiddeltabletter til implanterbare lægemiddelafgivelsesindretninger
US9017312B2 (en) * 2009-09-10 2015-04-28 Taris Biomedical Llc Implantable device for controlled drug delivery
US8604810B2 (en) 2009-10-16 2013-12-10 Microchips, Inc. Multi-channel potentiostat for biosensor arrays
US8862448B2 (en) 2009-10-19 2014-10-14 Theranos, Inc. Integrated health data capture and analysis system
US8919605B2 (en) 2009-11-30 2014-12-30 Intuity Medical, Inc. Calibration material delivery devices and methods
US8177747B2 (en) 2009-12-22 2012-05-15 Alcon Research, Ltd. Method and apparatus for drug delivery
US8673018B2 (en) 2010-02-05 2014-03-18 AMx Tek LLC Methods of using water-soluble inorganic compounds for implants
WO2011097634A1 (en) 2010-02-08 2011-08-11 On Demand Therapeutics, Inc. Low-permeability, laser-activated drug delivery device
US8828246B2 (en) * 2010-02-18 2014-09-09 Anpac Bio-Medical Science Co., Ltd. Method of fabricating micro-devices
US8668732B2 (en) 2010-03-23 2014-03-11 Boston Scientific Scimed, Inc. Surface treated bioerodible metal endoprostheses
US10413506B2 (en) 2010-04-03 2019-09-17 Praful Doshi Medical devices including medicaments and methods of making and using same including enhancing comfort, enhancing drug penetration, and treatment of myopia
EP2555751B8 (de) 2010-04-03 2018-02-14 Praful Doshi Verfahren zum beschichtigen von einer kontaktlinse
US20110251568A1 (en) * 2010-04-08 2011-10-13 Beeley Nathan R F Punctal plugs for controlled release of therapeutic agents
JP2013533847A (ja) 2010-04-23 2013-08-29 ユニバーシティ オブ マサチューセッツ コレステロール関連障害のａａｖベースの治療
EP2826860B1 (de) 2010-04-23 2018-08-22 University of Massachusetts Auf das ZNS abzielende AAV Vektoren und Verfahren zur Verwendung davon
DK2561067T3 (en) 2010-04-23 2019-03-11 Univ Florida RAAV-GUANYLAT CYCLE COMPOSITIONS AND PROCEDURES FOR TREATING LEVERS CONGENITAL AMAUROSE-1 (LCA1)
CH703278B1 (fr) 2010-06-15 2016-11-15 Csem Centre Suisse D'electronique Et De Microtechnique Sa - Rech Et Développement Appareil et plateforme pour analyse multiplex.
WO2011162823A1 (en) 2010-06-25 2011-12-29 Intuity Medical, Inc. Analyte monitoring methods and systems
RS61601B1 (sr) 2010-08-05 2021-04-29 Forsight Vision4 Inc Aparati za ubrizgavanje za dostavu leka
US9492315B2 (en) 2010-08-05 2016-11-15 Forsight Vision4, Inc. Implantable therapeutic device
US10617557B2 (en) 2010-08-05 2020-04-14 Forsight Vision4, Inc. Combined drug delivery methods and apparatus
WO2012019083A2 (en) 2010-08-06 2012-02-09 Microchips, Inc. Biosensor membrane composition, biosensor, and methods for making same
WO2012036550A1 (en) * 2010-09-13 2012-03-22 Nederlandse Organisatie Voor Toegepast-Natuurwetenschappelijk Onderzoek Tno Antimicrobial membrane containing silver nanoparticles
US9314523B2 (en) 2010-09-21 2016-04-19 Elwha Llc Ingestible salt grabber
CN104622789A (zh) 2010-11-01 2015-05-20 普西维达公司 用于递送治疗剂的可生物侵蚀的硅基装置
US20140031769A1 (en) 2010-11-19 2014-01-30 Forsight Vision4, Inc. Therapeutic agent formulations for implanted devices
US8679093B2 (en) 2010-11-23 2014-03-25 Microchips, Inc. Multi-dose drug delivery device and method
US9114111B2 (en) 2011-01-10 2015-08-25 Allergan, Inc. Methods for sustained treatment of bladder pain and irritative voiding
CN106323876B (zh) 2011-01-21 2020-02-14 西拉诺斯知识产权有限责任公司 样品使用最大化的系统和方法
JP6043730B2 (ja) 2011-02-04 2016-12-14 タリス バイオメディカル エルエルシー 低溶解性薬物の制御された放出のための植込み型装置
WO2012145739A1 (en) 2011-04-21 2012-10-26 Trustees Of Tufts College Compositions and methods for stabilization of active agents
ES2661680T3 (es) 2011-04-21 2018-04-03 University Of Massachusetts Composiciones basadas en VAAr y métodos para tratar deficiencias de alfa-1 anti-tripsina
EP2726016B1 (de) 2011-06-28 2023-07-19 ForSight Vision4, Inc. Vorrichtung zum sammeln einer flüssigkeitsprobe aus einer reservoirkammer einer therapeutischen vorrichtung für das auge
JP6523683B2 (ja) 2011-07-26 2019-06-05 ザ キュレイターズ オブ ザ ユニバーシティ オブ ミズーリ 加工食用肉
EP3750480B1 (de) 2011-08-03 2022-02-02 Intuity Medical, Inc. Vorrichtung zur entnahme von körperflüssigkeiten
EP2739252A4 (de) 2011-08-05 2015-08-12 Forsight Vision4 Inc Abgabe kleiner moleküle über eine implantierbare therapeutische vorrichtung
PT2747642T (pt) 2011-08-25 2021-07-27 Microchips Biotech Inc Dispositivos de contenção eficientes em termos de espaço e método de criação dos mesmos
US10427153B2 (en) 2011-08-25 2019-10-01 Microchips Biotech, Inc. Systems and methods for sealing a plurality of reservoirs of a microchip element with a sealing grid
US20140221963A1 (en) * 2011-08-25 2014-08-07 Edy E. Soffer Use of eating detection to control the release of biologically active agents
RS61758B1 (sr) 2011-09-16 2021-05-31 Forsight Vision4 Inc Aparati za razmenu tečnosti
JP2014534864A (ja) 2011-10-28 2014-12-25 プレサージュ バイオサイエンシズ，インコーポレイテッド 薬物デリバリー方法
US8414654B1 (en) * 2011-11-23 2013-04-09 Amendia, Inc. Bone implants and method of manufacture
US20150005595A1 (en) 2011-12-30 2015-01-01 Kibur Medical, Inc. Implantable devices and methods for evaluation of active agents
JP6563653B2 (ja) 2011-12-30 2019-08-21 カイバー メディカル， インコーポレイテッド 活性薬剤を評価するための移植可能なデバイスおよび方法
CA3207612A1 (en) 2012-01-26 2013-08-01 Longhorn Vaccines And Diagnostics, Llc Composite antigenic sequences and vaccines
US10010448B2 (en) 2012-02-03 2018-07-03 Forsight Vision4, Inc. Insertion and removal methods and apparatus for therapeutic devices
US9314571B1 (en) 2012-02-10 2016-04-19 Mphase Technologies, Inc. Drug delivery system
EP2841056A4 (de) 2012-04-23 2015-09-16 Massachusetts Inst Technology Stabile schichtweise beschichtete teilchen
US9101707B2 (en) 2012-04-27 2015-08-11 Gregory Zeltser Implantable bioartificial perfusion system
EP2856259B1 (de) * 2012-05-30 2018-12-26 The Regents of The University of California Abgabevorrichtungen für bioaktive mittel und verfahren zur herstellung und verwendung davon
US8795359B2 (en) 2012-06-13 2014-08-05 Elwha Llc Breast implant with regionalized analyte sensors and internal power source
US8790400B2 (en) 2012-06-13 2014-07-29 Elwha Llc Breast implant with covering and analyte sensors responsive to external power source
US9211185B2 (en) 2012-06-13 2015-12-15 Elwha Llc Breast implant with analyte sensors and internal power source
US9144489B2 (en) 2012-06-13 2015-09-29 Elwha Llc Breast implant with covering, analyte sensors and internal power source
US9144488B2 (en) 2012-06-13 2015-09-29 Elwha Llc Breast implant with analyte sensors responsive to external power source
US8808373B2 (en) 2012-06-13 2014-08-19 Elwha Llc Breast implant with regionalized analyte sensors responsive to external power source
US9136160B2 (en) * 2012-06-29 2015-09-15 Institute of Microelectronics, Chinese Academy of Sciences Solid hole array and method for forming the same
US9457128B2 (en) 2012-09-07 2016-10-04 President And Fellows Of Harvard College Scaffolds comprising nanoelectronic components for cells, tissues, and other applications
US9786850B2 (en) * 2012-09-07 2017-10-10 President And Fellows Of Harvard College Methods and systems for scaffolds comprising nanoelectronic components
MX366404B (es) 2012-11-15 2019-07-08 Apellis Pharmaceuticals Inc Analogos de compstatina de celula reactiva, de acción prolongada u objetivos y composiciones y metodos relacionados.
EP2934289B1 (de) 2012-12-21 2018-04-25 Microchips Biotech, Inc. Implantierbare medizinische vorrichtung zur minimal invasiven einführung
US9505737B2 (en) 2013-01-11 2016-11-29 Corsair Pharma, Inc. Treprostinil derivative compounds and methods of using same
WO2014110491A1 (en) 2013-01-11 2014-07-17 Theratrophix Llc Prodrugs of treprostinil
EP2953542A4 (de) 2013-02-06 2016-10-05 California Inst Of Techn Miniaturisierte implantierbare elektrochemische sensoren
FR3002694A1 (fr) 2013-02-25 2014-08-29 Commissariat Energie Atomique Systeme de stockage et de transport d'energie, notamment pour un dispositif implantable, et son procede de fabrication.
WO2014134029A1 (en) 2013-02-26 2014-09-04 Massachusetts Institute Of Technology Nucleic acid particles, methods and use thereof
EP2961466B1 (de) 2013-02-28 2018-12-19 Microchips Biotech, Inc. Implantierbare medizinische vorrichtung zur minimal invasiven einführung
EP2968113B8 (de) 2013-03-14 2020-10-28 Forsight Vision4, Inc. Systeme zur verzögerten intraokularen abgabe schwerlöslicher verbindungen aus einem implantat mit einem portabgabesystem
JP2016512839A (ja) 2013-03-15 2016-05-09 シヴィダ・ユーエス・インコーポレイテッドＰｓｉｖｉｄａ Ｕｓ， Ｉｎｃ． 治療物質の送達のための生体内分解性ケイ素系組成物
US9463244B2 (en) 2013-03-15 2016-10-11 Massachusetts Institute Of Technology Compositions and methods for nucleic acid delivery
US10308687B2 (en) 2013-03-15 2019-06-04 Apellis Pharmaceuticals, Inc. Cell-penetrating compstatin analogs and uses thereof
JP6517186B2 (ja) 2013-03-15 2019-05-22 タリス バイオメディカル エルエルシー 薬物透過性構成部材を備えた薬物送達デバイス、及び方法
CA2907681C (en) 2013-03-28 2022-11-22 Forsight Vision4, Inc. Ophthalmic implant for delivering therapeutic substances
EP2981305B1 (de) 2013-04-04 2019-06-12 The Arizona Board of Regents on behalf of the University of Arizona Materialien, systeme, vorrichtungen und verfahren für endoluminale elektropolymere pflasterung und versiegelung
EP2984912B1 (de) * 2013-04-12 2020-06-24 The Board of Trustees of the University of Illionis Vergängliche elektrochemische geräte
US10009996B2 (en) 2013-05-22 2018-06-26 Transient Electronics, Inc. Controlled transformation of non-transient electronics
WO2014205412A1 (en) 2013-06-21 2014-12-24 Intuity Medical, Inc. Analyte monitoring system with audible feedback
US9198898B2 (en) 2013-06-24 2015-12-01 Tigercat Pharma, Inc. Use of NK-1 receptor antagonists in pruritus
US8906951B1 (en) 2013-06-24 2014-12-09 Tigercat Pharma, Inc. Use of NK-1 receptor antagonists in pruritus
AU2014309012B2 (en) 2013-08-19 2019-03-14 Taris Biomedical Llc Multi-unit drug delivery devices and methods
WO2015038988A1 (en) 2013-09-13 2015-03-19 Modern Meadow, Inc. Edible and animal-product-free microcarriers for engineered meat
JP2017505138A (ja) 2014-02-05 2017-02-16 モダン メドー インコーポレイテッド 培養筋細胞から形成される乾燥食品
WO2015143078A1 (en) 2014-03-18 2015-09-24 University Of Massachusetts Raav-based compositions and methods for treating amyotrophic lateral sclerosis
KR101967133B1 (ko) * 2014-04-22 2019-04-10 한국과학기술원 플렉서블 약물 전달 소자 제조방법 및 플렉서블 약물 전달 소자
US10975391B2 (en) 2014-04-25 2021-04-13 University Of Massachusetts Recombinant AAV vectors useful for reducing immunity against transgene products
RU2695563C2 (ru) 2014-07-15 2019-07-24 Форсайт Вижн4, Инк. Способ и устройство для доставки глазного имплантата
JP6561109B2 (ja) 2014-07-16 2019-08-14 コルセア ファーマ インコーポレイテッド トレプロスチニル誘導体化合物およびその使用方法
WO2016022750A1 (en) 2014-08-08 2016-02-11 Forsight Vision4, Inc. Stable and soluble formulations of receptor tyrosine kinase inhibitors, and methods of preparation thereof
EP3795580A1 (de) 2014-10-03 2021-03-24 University of Massachusetts Hocheffiziente bibliotheksidentifizierte aav-vektoren
JP7023108B2 (ja) 2014-10-21 2022-02-21 ユニバーシティ オブ マサチューセッツ 組み換えａａｖバリアントおよびその使用
JP7037360B2 (ja) 2014-11-10 2022-03-16 フォーサイト・ビジョン フォー・インコーポレーテッド 拡張可能な薬物送達デバイス
AU2015364636B9 (en) 2014-12-16 2021-12-02 Board Of Regents Of The University Of Nebraska Gene therapy for Juvenile Batten Disease
JP7425534B2 (ja) 2015-04-23 2024-01-31 タリス バイオメディカル エルエルシー 薬物透過性構成要素を有する薬物送達デバイス及び方法
WO2016172155A1 (en) 2015-04-23 2016-10-27 University Of Massachusetts Modulation of aav vector transgene expression
EP3294448A4 (de) 2015-05-14 2018-12-12 Longhorn Vaccines and Diagnostics, LLC Schnellverfahren zur extraktion von nukleinsäuren aus biologischen proben
US9394227B1 (en) 2015-06-17 2016-07-19 Corsair Pharma, Inc. Treprostinil derivatives and compositions and uses thereof
US9643911B2 (en) 2015-06-17 2017-05-09 Corsair Pharma, Inc. Treprostinil derivatives and compositions and uses thereof
US10368788B2 (en) * 2015-07-23 2019-08-06 California Institute Of Technology System and methods for wireless drug delivery on command
US11913166B2 (en) 2015-09-21 2024-02-27 Modern Meadow, Inc. Fiber reinforced tissue composites
EP4349363A2 (de) 2015-10-07 2024-04-10 Apellis Pharmaceuticals, Inc. Dosierpläne
WO2017087902A1 (en) 2015-11-20 2017-05-26 Forsight Vision4, Inc. Porous structures for extended release drug delivery devices
CN108601811A (zh) 2015-12-04 2018-09-28 得克萨斯州大学系统董事会 用于免疫治疗的slc45a2肽
EP3205669B1 (de) 2016-02-15 2020-04-22 Modern Meadow, Inc. Biogefertigtes verbundstoffmaterial
ES2898337T3 (es) 2016-03-03 2022-03-07 Univ Massachusetts ADN dúplex lineal de extremos cerrados para la transferencia de genes no víricos
MX2018012021A (es) 2016-04-05 2019-01-24 Forsight Vision4 Inc Dispositivos de administracion de farmacos oculares implantables.
FR3054137B1 (fr) 2016-07-21 2021-08-27 Univ Angers Dispositif medical implantable d’injection locoregionale
US10406336B2 (en) * 2016-08-03 2019-09-10 Neil S. Davey Adjustable rate drug delivery implantable device
US20190185864A1 (en) 2016-08-23 2019-06-20 Akouos, Inc. Compositions and methods for treating non-age-associated hearing impairment in a human subject
CA3037337A1 (en) 2016-09-19 2018-03-22 Vaxess Technologies, Inc. Vaccine formulations with increased stability
US10457940B2 (en) 2016-09-22 2019-10-29 University Of Massachusetts AAV treatment of Huntington's disease
EP3526333A4 (de) 2016-10-13 2020-07-29 University of Massachusetts Aav-capsid-designs
WO2018106632A1 (en) 2016-12-05 2018-06-14 Corsair Pharma, Inc. Dermal and transdermal administration of treprostinil and salts thereof
CN110461314A (zh) * 2017-03-24 2019-11-15 伊英克加利福尼亚有限责任公司 用于递送活性分子的微单元系统
CN110446491A (zh) 2017-03-24 2019-11-12 伊英克加利福尼亚有限责任公司 调节活性物质给予速率的包含带电粒子或磁性粒子的微单元递送系统
AU2018249627A1 (en) 2017-04-07 2019-10-31 Apellis Pharmaceuticals, Inc. Dosing regimens and related compositions and methods
CN108968976B (zh) 2017-05-31 2022-09-13 心脏起搏器股份公司 具有化学传感器的植入式医疗设备
US10737090B2 (en) 2017-07-11 2020-08-11 Medtronic, Inc. External defibrillation electrode conductive electrolyte dispersal pad
US10508755B2 (en) * 2017-07-21 2019-12-17 International Business Machines Corporation Fluid delivery device with hydrophobic surface
US11304893B2 (en) 2017-07-24 2022-04-19 California Institute Of Technology Low power, chemically amplified, electrically removable barrier
CN109381195B (zh) 2017-08-10 2023-01-10 心脏起搏器股份公司 包括电解质传感器融合的系统和方法
CN109419515B (zh) 2017-08-23 2023-03-24 心脏起搏器股份公司 具有分级激活的可植入化学传感器
WO2019067218A1 (en) * 2017-09-26 2019-04-04 Medtronic Minimed, Inc. SENSOR-BASED PHYSIOLOGICAL CHARACTERISTIC PACKAGE PACK WITH INTEGRATED WIRELESS TRANSMITTER
US11419947B2 (en) 2017-10-30 2022-08-23 Massachusetts Institute Of Technology Layer-by-layer nanoparticles for cytokine therapy in cancer treatment
AU2018253595A1 (en) 2017-11-13 2019-05-30 Modern Meadow, Inc. Biofabricated leather articles having zonal properties
TWI682787B (zh) 2017-11-14 2020-01-21 美商伊英克加利福尼亞有限責任公司 包含多孔導電電極層之電泳主動遞送系統
BR112020010053A2 (pt) 2017-11-21 2020-11-03 Forsight Vision4, Inc. aparelho para troca de fluido para sistema de liberação de porta expansível e métodos de uso do mesmo
EP3713558A4 (de) 2017-11-22 2021-10-13 Panorama Research Inc. Aminoadamantylnitratverbindungen und ihre verwendung zur behandlung von zns-erkrankungen
CN109864746B (zh) 2017-12-01 2023-09-29 心脏起搏器股份公司 用于医学装置的多模式分析物传感器
CN109864747B (zh) 2017-12-05 2023-08-25 心脏起搏器股份公司 多模式分析物传感器光电子接口
JP2021519065A (ja) 2018-03-23 2021-08-10 ユニバーシティ オブ マサチューセッツ 骨障害を処置するための遺伝子治療法
US11472848B2 (en) 2018-04-27 2022-10-18 University Of Massachusetts AAV capsids identified by in vivo library selection
WO2020112967A1 (en) 2018-11-29 2020-06-04 University Of Massachusetts Modulation of sptlc1 via recombinant adeno-associated vectors
CA3126135A1 (en) 2019-01-09 2020-07-16 Twenty Twenty Therapeutics Llc Eye mounted device for therapeutic agent release
US11464674B2 (en) 2019-01-09 2022-10-11 Twenty Twenty Therapeutics Llc Programmable therapeutic agent delivery from eye mounted device
CA3121853A1 (en) 2019-01-17 2020-07-23 Modern Meadow, Inc. Layered collagen materials and methods of making the same
EP3927380A1 (de) 2019-02-22 2021-12-29 University of Massachusetts Oxr1-gentherapie
US20220340643A1 (en) 2019-09-13 2022-10-27 Rutgers, The State University Of New Jersey Aav-compatible laminin-linker polymerization proteins
JP2022553563A (ja) * 2019-11-01 2022-12-23 ダーレ エムビー インコーポレイテッド 二段階マイクロチップ薬物送達デバイスおよび方法
US11938214B2 (en) 2019-11-27 2024-03-26 E Ink Corporation Benefit agent delivery system comprising microcells having an electrically eroding sealing layer
BR112022016596A2 (pt) 2020-02-21 2022-11-16 Akouos Inc Composições e métodos para o tratamento de debilitação auditiva não associada à idade em um indivíduo humano
WO2021202494A1 (en) 2020-03-31 2021-10-07 University Of Massachusetts Aav capsids variants and uses thereof
CN115803084A (zh) 2020-05-21 2023-03-14 得克萨斯大学体系董事会 具有vgll1特异性的t细胞受体和其用途
US20230340041A1 (en) 2020-08-17 2023-10-26 Massachusetts Institute Of Technology Shank3 gene therapy approaches
BR102020019674A2 (pt) * 2020-09-27 2022-04-12 Christiane Dias Maués Dispositivo protético tubular cilíndrico; e dispositivo protético com matriz biológica não-polimérica de suporte para liberação de fármacos, induzida por microchip e nanossensores de operabilidade e monitoramento remotos
CN116322881A (zh) 2020-10-29 2023-06-23 伊英克加利福尼亚有限责任公司 用于递送有益剂的微单元系统
JP2023545106A (ja) 2020-10-29 2023-10-26 イー インク カリフォルニア， エルエルシー 親水性活性分子を送達するためのマイクロセルシステム
TW202237168A (zh) 2020-11-29 2022-10-01 美商希皮恩製藥公司 環孢素類似物作為抗血栓劑之用途
US11674154B2 (en) 2020-12-03 2023-06-13 University Of Massachusetts Gene therapeutics for fibrodysplasia ossificans progressiva
AU2022272489A1 (en) 2021-05-10 2023-11-30 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Pharmaceutical compositions for treating neurological conditions
WO2023056329A1 (en) 2021-09-30 2023-04-06 Akouos, Inc. Compositions and methods for treating kcnq4-associated hearing loss
WO2023164545A1 (en) 2022-02-23 2023-08-31 Massachusetts Institute Of Technology Methods for upregulating shank3 expression

Family Cites Families (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3692027A (en) * 1971-04-23 1972-09-19 Everett H Ellinwood Jr Implanted medication dispensing device and method
US4003379A (en) * 1974-04-23 1977-01-18 Ellinwood Jr Everett H Apparatus and method for implanted self-powered medication dispensing
US4146029A (en) * 1974-04-23 1979-03-27 Ellinwood Jr Everett H Self-powered implanted programmable medication system and method
US4360019A (en) * 1979-02-28 1982-11-23 Andros Incorporated Implantable infusion device
US4731051A (en) * 1979-04-27 1988-03-15 The Johns Hopkins University Programmable control means for providing safe and controlled medication infusion
JPS57163309A (en) * 1981-04-01 1982-10-07 Olympus Optical Co Ltd Capsule apparatus for medical use
GB8422876D0 (en) * 1984-09-11 1984-10-17 Secr Defence Silicon implant devices
US4585652A (en) * 1984-11-19 1986-04-29 Regents Of The University Of Minnesota Electrochemical controlled release drug delivery system
US5042975A (en) * 1986-07-25 1991-08-27 Rutgers, The State University Of New Jersey Iontotherapeutic device and process and iontotherapeutic unit dose
US4731049A (en) * 1987-01-30 1988-03-15 Ionics, Incorporated Cell for electrically controlled transdermal drug delivery
US5387419A (en) * 1988-03-31 1995-02-07 The University Of Michigan System for controlled release of antiarrhythmic agents
US4994023A (en) * 1989-08-08 1991-02-19 Wellinghoff Stephen T Electrochemical drug release and article
US5041107A (en) * 1989-10-06 1991-08-20 Cardiac Pacemakers, Inc. Electrically controllable, non-occluding, body implantable drug delivery system
US5170801A (en) * 1990-10-02 1992-12-15 Glaxo Inc. Medical capsule device actuated by radio-frequency (rf) signal
US5167625A (en) * 1990-10-09 1992-12-01 Sarcos Group Multiple vesicle implantable drug delivery system
US5196002A (en) * 1990-10-09 1993-03-23 University Of Utah Research Foundation Implantable drug delivery system with piston acutation
US5254081A (en) * 1991-02-01 1993-10-19 Empi, Inc. Multiple site drug iontophoresis electronic device and method
US5391164A (en) * 1991-05-03 1995-02-21 Giampapa; Vincent C. Subcutaneous implantable multiple-agent delivery system
US5279607A (en) * 1991-05-30 1994-01-18 The State University Of New York Telemetry capsule and process
EP0604504A4 (de) * 1991-08-26 1995-05-17 Univ Rutgers Iontotherapeutische vorrichtung und verfahren.
US5756117A (en) * 1992-04-08 1998-05-26 International Medical Asscociates, Inc. Multidose transdermal drug delivery system
US5318557A (en) * 1992-07-13 1994-06-07 Elan Medical Technologies Limited Medication administering device
US5368588A (en) * 1993-02-26 1994-11-29 Bettinger; David S. Parenteral fluid medication reservoir pump
US5366454A (en) * 1993-03-17 1994-11-22 La Corporation De L'ecole Polytechnique Implantable medication dispensing device
US5368704A (en) * 1993-08-06 1994-11-29 Teknekron Corporation Micro-electrochemical valves and method
US5900160A (en) * 1993-10-04 1999-05-04 President And Fellows Of Harvard College Methods of etching articles via microcontact printing
US5518680A (en) * 1993-10-18 1996-05-21 Massachusetts Institute Of Technology Tissue regeneration matrices by solid free form fabrication techniques
US5490962A (en) * 1993-10-18 1996-02-13 Massachusetts Institute Of Technology Preparation of medical devices by solid free-form fabrication methods
US5798042A (en) * 1994-03-07 1998-08-25 Regents Of The University Of California Microfabricated filter with specially constructed channel walls, and containment well and capsule constructed with such filters
US5660680A (en) * 1994-03-07 1997-08-26 The Regents Of The University Of California Method for fabrication of high vertical aspect ratio thin film structures
US5651900A (en) * 1994-03-07 1997-07-29 The Regents Of The University Of California Microfabricated particle filter
US5770076A (en) * 1994-03-07 1998-06-23 The Regents Of The University Of California Micromachined capsules having porous membranes and bulk supports
US5893974A (en) * 1994-03-07 1999-04-13 Regents Of University Of California Microfabricated capsules for immunological isolation of cell transplants
US5985328A (en) * 1994-03-07 1999-11-16 Regents Of The University Of California Micromachined porous membranes with bulk support
US5992769A (en) * 1995-06-09 1999-11-30 The Regents Of The University Of Michigan Microchannel system for fluid delivery
SE9502258D0 (sv) * 1995-06-21 1995-06-21 Pharmacia Biotech Ab Method for the manufacture of a membrane-containing microstructure
US5830659A (en) * 1996-09-13 1998-11-03 University Of Utah Research Foundation Active microtubule-based separations by kinesins
US5938923A (en) * 1997-04-15 1999-08-17 The Regents Of The University Of California Microfabricated filter and capsule using a substrate sandwich

Cited By (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8066763B2 (en) 1998-04-11 2011-11-29 Boston Scientific Scimed, Inc. Drug-releasing stent with ceramic-containing layer
US8574615B2 (en) 2006-03-24 2013-11-05 Boston Scientific Scimed, Inc. Medical devices having nanoporous coatings for controlled therapeutic agent delivery
US8187620B2 (en) 2006-03-27 2012-05-29 Boston Scientific Scimed, Inc. Medical devices comprising a porous metal oxide or metal material and a polymer coating for delivering therapeutic agents
US8815275B2 (en) 2006-06-28 2014-08-26 Boston Scientific Scimed, Inc. Coatings for medical devices comprising a therapeutic agent and a metallic material
US8771343B2 (en) 2006-06-29 2014-07-08 Boston Scientific Scimed, Inc. Medical devices with selective titanium oxide coatings
US8353949B2 (en) 2006-09-14 2013-01-15 Boston Scientific Scimed, Inc. Medical devices with drug-eluting coating
US7981150B2 (en) 2006-11-09 2011-07-19 Boston Scientific Scimed, Inc. Endoprosthesis with coatings
US8070797B2 (en) 2007-03-01 2011-12-06 Boston Scientific Scimed, Inc. Medical device with a porous surface for delivery of a therapeutic agent
US8431149B2 (en) 2007-03-01 2013-04-30 Boston Scientific Scimed, Inc. Coated medical devices for abluminal drug delivery
US8067054B2 (en) 2007-04-05 2011-11-29 Boston Scientific Scimed, Inc. Stents with ceramic drug reservoir layer and methods of making and using the same
US7976915B2 (en) 2007-05-23 2011-07-12 Boston Scientific Scimed, Inc. Endoprosthesis with select ceramic morphology
US8002823B2 (en) 2007-07-11 2011-08-23 Boston Scientific Scimed, Inc. Endoprosthesis coating
US7942926B2 (en) 2007-07-11 2011-05-17 Boston Scientific Scimed, Inc. Endoprosthesis coating
US9284409B2 (en) 2007-07-19 2016-03-15 Boston Scientific Scimed, Inc. Endoprosthesis having a non-fouling surface
US8815273B2 (en) 2007-07-27 2014-08-26 Boston Scientific Scimed, Inc. Drug eluting medical devices having porous layers
US7931683B2 (en) 2007-07-27 2011-04-26 Boston Scientific Scimed, Inc. Articles having ceramic coated surfaces
US8221822B2 (en) 2007-07-31 2012-07-17 Boston Scientific Scimed, Inc. Medical device coating by laser cladding
US8900292B2 (en) 2007-08-03 2014-12-02 Boston Scientific Scimed, Inc. Coating for medical device having increased surface area
US8216632B2 (en) 2007-11-02 2012-07-10 Boston Scientific Scimed, Inc. Endoprosthesis coating
US8029554B2 (en) 2007-11-02 2011-10-04 Boston Scientific Scimed, Inc. Stent with embedded material
US7938855B2 (en) 2007-11-02 2011-05-10 Boston Scientific Scimed, Inc. Deformable underlayer for stent
US8920491B2 (en) 2008-04-22 2014-12-30 Boston Scientific Scimed, Inc. Medical devices having a coating of inorganic material
US8932346B2 (en) 2008-04-24 2015-01-13 Boston Scientific Scimed, Inc. Medical devices having inorganic particle layers
US8449603B2 (en) 2008-06-18 2013-05-28 Boston Scientific Scimed, Inc. Endoprosthesis coating
US8231980B2 (en) 2008-12-03 2012-07-31 Boston Scientific Scimed, Inc. Medical implants including iridium oxide
US8071156B2 (en) 2009-03-04 2011-12-06 Boston Scientific Scimed, Inc. Endoprostheses
US8287937B2 (en) 2009-04-24 2012-10-16 Boston Scientific Scimed, Inc. Endoprosthese

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CA2258898A1 (en) 1998-01-08
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US6123861A (en) 2000-09-26
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PT914092E (pt) 2002-09-30
DE69712063D1 (de) 2002-05-23
JP2000513725A (ja) 2000-10-17
DK0914092T3 (da) 2002-08-12
EP0914092B1 (de) 2002-04-17
WO1998000107A2 (en) 1998-01-08
EP0914092A2 (de) 1999-05-12
ATE216219T1 (de) 2002-05-15

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