DE60120660D1 - Zusammensetzungen von vernetzbaren prepolymeren für bioabbaubare implantate - Google Patents

Zusammensetzungen von vernetzbaren prepolymeren für bioabbaubare implantate

Info

Publication number
DE60120660D1
DE60120660D1 DE60120660T DE60120660T DE60120660D1 DE 60120660 D1 DE60120660 D1 DE 60120660D1 DE 60120660 T DE60120660 T DE 60120660T DE 60120660 T DE60120660 T DE 60120660T DE 60120660 D1 DE60120660 D1 DE 60120660D1
Authority
DE
Germany
Prior art keywords
prepolymers
composition
bioabcable
implants
networked
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60120660T
Other languages
English (en)
Other versions
DE60120660T2 (de
Inventor
Honore Schacht
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Universiteit Gent
Original Assignee
Universiteit Gent
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Universiteit Gent filed Critical Universiteit Gent
Publication of DE60120660D1 publication Critical patent/DE60120660D1/de
Application granted granted Critical
Publication of DE60120660T2 publication Critical patent/DE60120660T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/54Biologically active materials, e.g. therapeutic substances
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14Macromolecular materials
    • A61L27/16Macromolecular materials obtained by reactions only involving carbon-to-carbon unsaturated bonds
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08FMACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F290/00Macromolecular compounds obtained by polymerising monomers on to polymers modified by introduction of aliphatic unsaturated end or side groups
    • C08F290/08Macromolecular compounds obtained by polymerising monomers on to polymers modified by introduction of aliphatic unsaturated end or side groups on to polymers modified by introduction of unsaturated side groups
    • C08F290/14Polymers provided for in subclass C08G
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08GMACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G63/00Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
    • C08G63/91Polymers modified by chemical after-treatment
    • C08G63/912Polymers modified by chemical after-treatment derived from hydroxycarboxylic acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/60Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
    • A61L2300/602Type of release, e.g. controlled, sustained, slow
    • A61L2300/604Biodegradation
DE60120660T 2000-04-03 2001-04-03 Zusammensetzungen von vernetzbaren prepolymeren für bioabbaubare implantate Expired - Lifetime DE60120660T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP00201198A EP1142596A1 (de) 2000-04-03 2000-04-03 Zusammensetzung von vernetzbaren Prepolymeren zum Gebrauch in therapeutisch aktiven, bioabbaubaren Implantaten
EP00201198 2000-04-03
PCT/EP2001/003766 WO2001074411A1 (en) 2000-04-03 2001-04-03 Compositions of crosslinkable prepolymers for biodegradable implants

Publications (2)

Publication Number Publication Date
DE60120660D1 true DE60120660D1 (de) 2006-07-27
DE60120660T2 DE60120660T2 (de) 2007-06-14

Family

ID=8171297

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60120660T Expired - Lifetime DE60120660T2 (de) 2000-04-03 2001-04-03 Zusammensetzungen von vernetzbaren prepolymeren für bioabbaubare implantate

Country Status (7)

Country Link
US (1) US6933328B2 (de)
EP (2) EP1142596A1 (de)
AT (1) ATE329630T1 (de)
AU (2) AU2001262159B2 (de)
CA (1) CA2404683C (de)
DE (1) DE60120660T2 (de)
WO (1) WO2001074411A1 (de)

Families Citing this family (73)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6786915B2 (en) * 2000-04-19 2004-09-07 Radi Medical Systems Ab Reinforced absorbable medical sealing device
AU2001288829A1 (en) * 2000-09-06 2002-03-22 Ap Pharma, Inc. Degradable polyacetal polymers
ATE316105T1 (de) * 2000-11-20 2006-02-15 Matrix Innovation Inc Herstellung amphiphiler fester träger für die peptidsynthese und die bioorganische und organische chemie
EP1341484B1 (de) * 2000-12-08 2009-05-06 Osteotech, Inc. Implantat für orthopädische anwendungen
US6590059B2 (en) 2001-05-11 2003-07-08 Ap Pharma, Inc. Bioerodible polyorthoesters from dioxolane-based diketene acetals
US8740987B2 (en) * 2001-06-04 2014-06-03 Warsaw Orthopedic, Inc. Tissue-derived mesh for orthopedic regeneration
JP4624678B2 (ja) 2002-02-21 2011-02-02 パイオニア・サージカル・オーソバイオロジックス,インコーポレイテッド 架橋生物活性ヒドロゲルマトリックス
US20080086792A1 (en) 2006-10-13 2008-04-17 Thomas Charles Kuracina Method and apparatus for diverting sweat, liquid, moisture or the like from an eye
US20040127563A1 (en) * 2002-03-22 2004-07-01 Deslauriers Richard J. Methods of performing medical procedures which promote bone growth, compositions which promote bone growth, and methods of making such compositions
SG145565A1 (en) * 2002-08-12 2008-09-29 Osteotech Inc Synthesis of a bone-polymer composite material
CN101632843A (zh) * 2002-08-20 2010-01-27 精密技术公司 骨生长诱导材料的携带和输送用组合物以及生产和应用该组合物的方法
WO2004032988A2 (en) * 2002-10-08 2004-04-22 Osteotech, Inc. Coupling agents for orthopedic biomaterials
US20040152800A1 (en) * 2002-10-09 2004-08-05 Shalaby Shalaby W. Photo-crosslinkable, crystalline, polyaxial, absorbable polyester for rapid prototyping
US7045589B2 (en) 2002-11-15 2006-05-16 A.P. Pharma, Inc. Bioerodible poly(ortho esters) from dioxane-based di(ketene acetals), and block copolymers containing them
EP1578957B1 (de) * 2002-12-12 2015-04-15 Warsaw Orthopedic, Inc. Formbarer und einstellbarer polymer-knochenverbund und herstellungsverfahren dafür
US20060052471A1 (en) * 2003-02-27 2006-03-09 A Enterprises, Inc. Initiators and crosslinkable polymeric materials
US7393493B2 (en) * 2003-02-27 2008-07-01 A Enterprises, Inc. Crosslinkable polymeric materials and their applications
DE10314082A1 (de) * 2003-03-28 2004-10-21 Mcs Micro Carrier Systems Gmbh Biodegradierbares injizierbares Implantat
US7067123B2 (en) 2003-04-29 2006-06-27 Musculoskeletal Transplant Foundation Glue for cartilage repair
US7901457B2 (en) 2003-05-16 2011-03-08 Musculoskeletal Transplant Foundation Cartilage allograft plug
CA2536041A1 (en) * 2003-11-10 2005-05-26 Angiotech International Ag Medical implants and fibrosis-inducing agents
US8012210B2 (en) 2004-01-16 2011-09-06 Warsaw Orthopedic, Inc. Implant frames for use with settable materials and related methods of use
JP2007519492A (ja) * 2004-01-30 2007-07-19 オステオテック,インコーポレイテッド 脊椎融合のための積み重ねインプラント
TW200533385A (en) * 2004-03-03 2005-10-16 Commw Scient Ind Res Org Biocompatible polymer compositions for dual or multi staged curing
EP1789088A4 (de) 2004-03-24 2009-12-30 Doctor S Res Group Inc Verfahren zur durchführung von medizinischen verfahren zur förderung des knochenwachstums, verfahren zur herstellung von zusammensetzungen zur förderung des knochenwachstums und gerät zur verwendung bei solchen verfahren
ATE462451T1 (de) * 2004-06-16 2010-04-15 Affinergy Inc Grenzflächenbiomaterialien zur förderung der anhaftung von zielanalyten
US7837740B2 (en) 2007-01-24 2010-11-23 Musculoskeletal Transplant Foundation Two piece cancellous construct for cartilage repair
FI122108B (fi) * 2004-11-17 2011-08-31 Jvs Polymers Oy Silloittuva biopolymeeri
WO2006088866A2 (en) * 2005-02-14 2006-08-24 Indiana University Research And Technology Corporation Biodegradable load-bearing carrier for bone regeneration
AT501700B1 (de) * 2005-04-14 2011-03-15 Univ Wien Tech Mit strahlung härtbare, biologisch abbaubare zusammensetzungen und deren verwendung als stützmaterialien für den knochenersatz
CA2611693A1 (en) * 2005-06-15 2006-12-28 Surmodics, Inc. Macromer composition including light activated initiator
US7815926B2 (en) 2005-07-11 2010-10-19 Musculoskeletal Transplant Foundation Implant for articular cartilage repair
WO2007048105A2 (en) * 2005-10-19 2007-04-26 A Enterprises, Inc. Curable bone substitute
CA2630661A1 (en) * 2005-11-29 2007-06-07 Indiana University Research And Technology Corporation Biodegradable implant ploymers and composites
CA2637606C (en) * 2006-01-19 2013-03-19 Osteotech, Inc. Porous osteoimplant
EP1976460A4 (de) 2006-01-19 2012-06-20 Warsaw Orthopedic Inc Injizierbare und formbare knochenersatzmaterialien
US20090311303A1 (en) * 2006-04-27 2009-12-17 Queensland University Of Technology Biodegradable implants for bone fusion and compositions therefor
EP2044142A2 (de) 2006-06-29 2009-04-08 Medtronic, Inc. Poly(orthoester)polymere sowie herstellungs- und verwendungsverfahren dafür
GB0618963D0 (en) * 2006-09-26 2006-11-08 Ucl Business Plc Formulations and composites with reactive fillers
US8435551B2 (en) 2007-03-06 2013-05-07 Musculoskeletal Transplant Foundation Cancellous construct with support ring for repair of osteochondral defects
AT506168B1 (de) * 2007-11-23 2012-02-15 Univ Wien Tech Verwendung von zusammensetzungen zur herstellung biologisch abbaubarer, bioverträglicher, vernetzter polymere auf basis von polyvinylalkohol
EP2219697A2 (de) * 2007-11-23 2010-08-25 Technische Universität Wien Durch polymerisation härtbare zusammensetzung zur herstellung biologisch abbaubarer, bioverträglicher, vernetzter polymere auf basis von polyvinylalkohol
CA2717725A1 (en) 2008-03-05 2009-09-11 Musculoskeletal Transplant Foundation Cancellous constructs, cartilage particles and combinations of cancellous constructs and cartilage particles
US9068065B2 (en) 2008-04-14 2015-06-30 Basf Se Hydrolytically decomposable ionic copolymers
DE102008018905A1 (de) 2008-04-14 2009-10-15 Philipps-Universität Marburg Hydrolytisch abbaubare ionische Copolymerisate
DE102008028146A1 (de) 2008-06-14 2009-12-17 Philipps-Universität Marburg Neue hydrolytisch abbaubare ionische Copolymerisate
US8956642B2 (en) 2008-04-18 2015-02-17 Medtronic, Inc. Bupivacaine formulation in a polyorthoester carrier
US8475823B2 (en) 2008-04-18 2013-07-02 Medtronic, Inc. Baclofen formulation in a polyorthoester carrier
WO2009152276A2 (en) 2008-06-10 2009-12-17 University Of North Carolina At Charlotte Photoacid generators and lithographic resists comprising the same
WO2011025650A1 (en) * 2009-08-25 2011-03-03 Genzyme Corporation Cartilage repair
US8829069B2 (en) 2010-05-26 2014-09-09 Medisse B.V. Method for preparing a degradable polymer network
US20120101593A1 (en) 2010-10-20 2012-04-26 BIOS2 Medical, Inc. Implantable polymer for bone and vascular lesions
US10525168B2 (en) 2010-10-20 2020-01-07 206 Ortho, Inc. Method and apparatus for treating bone fractures, and/or for fortifying and/or augmenting bone, including the provision and use of composite implants, and novel composite structures which may be used for medical and non-medical applications
US11484627B2 (en) 2010-10-20 2022-11-01 206 Ortho, Inc. Method and apparatus for treating bone fractures, and/or for fortifying and/or augmenting bone, including the provision and use of composite implants, and novel composite structures which may be used for medical and non-medical applications
US10525169B2 (en) 2010-10-20 2020-01-07 206 Ortho, Inc. Method and apparatus for treating bone fractures, and/or for fortifying and/or augmenting bone, including the provision and use of composite implants, and novel composite structures which may be used for medical and non-medical applications
US11207109B2 (en) 2010-10-20 2021-12-28 206 Ortho, Inc. Method and apparatus for treating bone fractures, and/or for fortifying and/or augmenting bone, including the provision and use of composite implants, and novel composite structures which may be used for medical and non-medical applications
US11058796B2 (en) 2010-10-20 2021-07-13 206 Ortho, Inc. Method and apparatus for treating bone fractures, and/or for fortifying and/or augmenting bone, including the provision and use of composite implants, and novel composite structures which may be used for medical and non-medical applications
US11291483B2 (en) 2010-10-20 2022-04-05 206 Ortho, Inc. Method and apparatus for treating bone fractures, and/or for fortifying and/or augmenting bone, including the provision and use of composite implants
CN102120817A (zh) * 2011-01-11 2011-07-13 同济大学 一种交联型聚乳酸及其制备方法
US20120219629A1 (en) * 2011-02-25 2012-08-30 Empire Technology Development Llc Compositions and methods for controlled delivery of compounds
WO2013067195A1 (en) 2011-11-02 2013-05-10 Halscion, Inc. Methods and compositions for wound treatment
WO2013130877A1 (en) 2012-02-29 2013-09-06 206 Ortho, Inc. Method and apparatus for treating bone fractures, including the use of composite implants
EP3269335B1 (de) 2012-10-02 2019-03-06 McCullen, Seth Implantierbare vorrichtungen für muskuloskelettäre reparatur und regeneration
US9951178B2 (en) * 2012-10-09 2018-04-24 Shanghai Micoport Medical (Group) Co., Ltd. Biodegradable cross-linked polymer, vascular stent and manufacturing methods therefor
EP3795635A1 (de) 2013-05-23 2021-03-24 206 ORTHO, Inc. Vorrichtung zur behandlung von knochenbrüchen und/oder zur stärkung und/oder vermehrung von knochen einschliesslich der bereitstellung und verwendung zusammengesetzter implantate
WO2016054463A1 (en) 2014-10-02 2016-04-07 Mccullen Seth Anatomically designed meniscus implantable devices
CN105818492B (zh) * 2016-03-29 2018-02-16 中材科技股份有限公司 一种生物活性磷酸盐基连续玻璃纤维纺织复合材料及其用途
WO2018204440A2 (en) 2017-05-02 2018-11-08 Mccullen Seth Composite joint implant
US11331854B2 (en) * 2018-03-26 2022-05-17 Arevo, Inc. System and method for dispensing composite filaments for additive manufacturing
WO2020150332A1 (en) * 2019-01-15 2020-07-23 University Of Massachusetts Eggshell particle containing hydrogels and prepolymer compositions for biomedical applications
GB201910895D0 (en) * 2019-07-31 2019-09-11 Univ Birmingham Curable monomers and compositions
CN111067670B (zh) * 2019-12-24 2022-10-14 北京壹点灵动科技有限公司 髋臼骨缺损的评估方法及装置、电子设备
JP2021191810A (ja) * 2020-06-05 2021-12-16 日清紡ホールディングス株式会社 海洋生分解促進剤

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5085861A (en) * 1987-03-12 1992-02-04 The Beth Israel Hospital Association Bioerodable implant composition comprising crosslinked biodegradable polyesters
US4938763B1 (en) * 1988-10-03 1995-07-04 Atrix Lab Inc Biodegradable in-situ forming implants and method of producing the same
US5108755A (en) * 1989-04-27 1992-04-28 Sri International Biodegradable composites for internal medical use
US5410016A (en) * 1990-10-15 1995-04-25 Board Of Regents, The University Of Texas System Photopolymerizable biodegradable hydrogels as tissue contacting materials and controlled-release carriers
DE69530919T2 (de) * 1994-04-08 2004-05-13 Atrix Laboratories, Inc., Fort Collins Beigeordnetes polymersystem zur verwendung mit einer medizinischen vorrichtung
US5900245A (en) * 1996-03-22 1999-05-04 Focal, Inc. Compliant tissue sealants
US5703200A (en) * 1996-03-15 1997-12-30 Ethicon, Inc. Absorbable copolymers and blends of 6,6-dialkyl-1,4-dioxepan-2-one and its cyclic dimer
ZA978537B (en) * 1996-09-23 1998-05-12 Focal Inc Polymerizable biodegradable polymers including carbonate or dioxanone linkages.
US5837752A (en) * 1997-07-17 1998-11-17 Massachusetts Institute Of Technology Semi-interpenetrating polymer networks
DE69920198T2 (de) * 1998-04-13 2005-09-22 Massachusetts Institute Of Technology, Cambridge Kamm-polymere zur regelung der zelloberflächenwechselwirkung
US6171610B1 (en) * 1998-04-24 2001-01-09 University Of Massachusetts Guided development and support of hydrogel-cell compositions
MXPA01007777A (es) 1999-02-01 2003-10-06 Eidgenoess Tech Hochschule Bio-materiales formadas por reaccion de adicion nucleofila a grupos insaturados conjugados.
CA2410637C (en) 2000-05-31 2007-04-10 Mnemoscience Gmbh Shape memory polymers seeded with dissociated cells for tissue engineering

Also Published As

Publication number Publication date
AU2001262159B2 (en) 2005-07-14
EP1267953A1 (de) 2003-01-02
WO2001074411A1 (en) 2001-10-11
US6933328B2 (en) 2005-08-23
EP1267953B1 (de) 2006-06-14
EP1142596A1 (de) 2001-10-10
CA2404683A1 (en) 2001-10-11
ATE329630T1 (de) 2006-07-15
AU6215901A (en) 2001-10-15
DE60120660T2 (de) 2007-06-14
US20030114552A1 (en) 2003-06-19
CA2404683C (en) 2011-02-08

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