CN105250048A - Coronary artery covered stent - Google Patents
Coronary artery covered stent Download PDFInfo
- Publication number
- CN105250048A CN105250048A CN201510768484.9A CN201510768484A CN105250048A CN 105250048 A CN105250048 A CN 105250048A CN 201510768484 A CN201510768484 A CN 201510768484A CN 105250048 A CN105250048 A CN 105250048A
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- China
- Prior art keywords
- stent
- coronary artery
- support
- overlay film
- anticoagulant
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- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Abstract
The invention relates to a coronary artery covered stent, comprising a stent, wherein the stent is of an integral metal pipe meshed structure which is formed by connecting a plurality of columns of beam column units; adjacent unit columns are symmetrically arranged, and are connected through a bridging bar; an anti-proliferative drug coating is respectively sprayed at two ends of the stent; an anticoagulant drug is sprayed on the middle section of the stent; a tubular film externally covers an anticoagulant drug coating on the middle section of the stent. The coronary artery covered stent has the advantages that the expansion uniformity is improved through the adoption of a highly symmetric structure; a large Ohm head radius is adopted, and the chamfer radius of the bracket edge of the stent is increased, so that the damage to a film by the stent is reduced; the anticoagulant drug coating is sprayed on the middle section of the stent, so that the probability of thrombosis incidence is reduced; a drug for inhibiting cell proliferation is sprayed at two ends of the stent, so that the blood vessel hyperplasia is prevented; an elastic expanded PTFE (Polytetrafluoroethylene) tubular film is adopted, the radial elongation is high, and the risk that a stent sealing film is broken is reduced.
Description
Technical field
Patent of the present invention relates to coronary artery disease interventional therapy medical instruments field, is particularly useful for accompanying the hemangioma of coronary stricture, fistula of artery and PCI art medium vessels breaks or the lesions treatment such as perforation uses coronary artery overlay film frame.
Background technology
Hemangioma, fistula of artery are a kind of common diseases of cardiovascular disease, blood tumor portion or the circulation of fistula portion smooth, very easily form thrombosis, bring out apoplexy, myocardial infarction, blood vessel distal block even downright bad, affect patients ' life quality; Once break in tumor portion or fistula portion, patient vitals will be seized in very short time; Although angiorrhexis or perforation in PCI art incidence rate extremely low, it has high fatality rate, has high risk.Because most of coronary stricture patient cycle is longer, and patient age is larger, vascular toughness is not enough, easily the acute even pernicious adverse events such as vascular tear are caused in narrow process of expansion in PCI art, if treatment not in time, cause patient dead in several minutes possibly.
Coronary artery overlay film frame interventional therapy is the treatment companion hemangioma of coronary stricture, fistula of artery and PCI art medium vessels breaks or a kind of the simplest method effectively, causing wound minimum to patient of the pathological changes such as perforation.
Summary of the invention
Cannot treat the deficiency of angiorrhexis in order to overcome conventional bracket in PCI art, the invention provides a kind of coronary artery overlay film frame, this support can also provide enough support force treatment coronary stricturees while shutoff blood vessel breakage blood flow.
In order to solve prior art Problems existing, the technical solution used in the present invention is:
Coronary artery overlay film frame, include support, described support is the bulk metal tubulose net structure be formed by connecting by some row beam-column unit, adjacent cell columns is symmetrical arranged and is connected by bridge muscle, two ends of support are coated with anti-proliferative drug coating, the interlude of support is coated with anticoagulant, is set with tubular film outside the interlude anticoagulant coating of support.
Described beam-column unit includes several beam columns, is connected and arrange according to sinusoidal wave form, the edge rounding of beam column between adjacent beam column by circular arc connecting rod.
Described tubular film adopts expanded PTFE, and has microcosmic pore.
Adopt between described tubular film and the interlude of support and extrude combination.
Described anticoagulant is heparin sodium.
Described anti-proliferative drug is any one in the derivant of paclitaxel, rapamycin and two kinds of medicines, or two or more the mixing in them.
The advantage that the present invention has and effect are:
Coronary artery overlay film frame of the present invention is owing to having the support of tubular metal net structure, adjacent cell columns is symmetrical arranged and is connected by bridge muscle, two ends of support are coated with anti-proliferative drug coating, the interlude of support is coated with anticoagulant coating, be set with the structure of tubular film outside the interlude anticoagulant coating of support, the structure of high symmetry improves expansion uniformity; Adopt large ohm head radius and increase stent strut edge rib chamfer radius, reducing support to the damage of film; The interlude spraying anticoagulant coating of support, reduces thrombosis occurrence probability; Two end-spray antiproliferative effect medicines of support, prevent vessel overgrowth; Employing has elastic expanded polytetrafluoroethyltube tube shape film, and radial extension rate is high, reduces the risk of stent occlusion film breakage; When support compresses, periosteum redundance is positioned at beam-column unit gap, is fixed between the two after strutting by the mutual squeezing action of support and blood vessel wall by film, makes periosteum hold state in pressure and strut state all without the risk that comes off; Expanded PTFE has remarkable biocompatibility, tiny micropore in its structure is beneficial to the growth of vascular cell, promote healing and the shutoff of blood vessel, owing to adopting outer film mulching method, tubular film is covered in bracket outer, reduce the contact area of blood vessel and metal rack, smooth muscle effectively can be stoped to internal stent hypertrophy, reduce the hyperplasia of vascular smooth muscle cell.Because tubular film inner support part is coated with anticoagulant, anti-Hemostatic Oral Liquid produces thrombosis at internal stent.
There is the function of shutoff blood vessel breakage in interventional therapy coronary stricture pathological process simultaneously; Owing to adopting bracket outer extruding film mulching method, without the need to making film, reducing the risk that in process of expansion, film is torn, without the need to carrying out gluing to film and support, eliminating the control unknown risks introducing glue reagent.
Accompanying drawing explanation
Below in conjunction with accompanying drawing, the present invention is further described.
Fig. 1 is coronary artery overlay film frame unfolding assumption diagram of the present invention;
Fig. 2 is the cross-sectional view of coronary artery overlay film frame beam column of the present invention.
Detailed description of the invention
As shown in Figure 1, 2, coronary artery overlay film frame, include support 1, described support 1 is the bulk metal tubulose net structure be formed by connecting by some row beam-column unit, be symmetrical arranged between adjacent cell columns and be connected by bridge muscle 3, two ends 12 of support are respectively string beam-column unit, the beam-column unit of end are coated with containing anti-proliferative drug coating, this coating is the polymer having degradation property, prevents vessel overgrowth; The interlude 11 of support is coated with anticoagulant, reduces thrombosis occurrence probability; Tubular film 2 is set with outside the interlude anticoagulant coating of support.
Described anti-proliferative drug be paclitaxel, rapamycin and and two kinds of medicines derivant in any one, or two or more the mixing in them.
Described anticoagulant is heparin sodium.
Described beam-column unit includes several beam columns 13, is connected and arrange according to sinusoidal wave form, the edge rounding of beam column between adjacent beam column by circular arc connecting rod 14.Adopt large ohm head radius and increase stent strut edge rib chamfer radius, reducing support to the damage of film.
Described tubular film adopts expanded PTFE, and expanded PTFE has microcosmic pore.
Adopt between described tubular film and the interlude of support and extrude combination.When support compresses, periosteum redundance is positioned at beam-column unit gap, is fixed between the two after strutting by the mutual squeezing action of support and blood vessel wall by film, makes periosteum hold state in pressure and strut state all without the risk that comes off.
Claims (6)
1. coronary artery overlay film frame, include support, it is characterized in that described support is the bulk metal tubulose net structure be formed by connecting by some row beam-column unit, adjacent cell columns is symmetrical arranged and is connected by bridge muscle, two ends of support are coated with anti-proliferative drug coating, the interlude of support is coated with anticoagulant, is set with tubular film outside the interlude anticoagulant coating of support.
2. coronary artery overlay film frame according to claim 1, is characterized in that described beam-column unit includes several beam columns, is connected and arrange according to sinusoidal wave form, the edge rounding of beam column between adjacent beam column by circular arc connecting rod.
3. coronary artery overlay film frame according to claim 1, is characterized in that described tubular film adopts expanded PTFE.
4. the coronary artery overlay film frame according to claim 1 or 3, is characterized in that adopting between described tubular film and the interlude of support extruding combination.
5. coronary artery overlay film frame according to claim 1, is characterized in that described anticoagulant is heparin sodium.
6. coronary artery overlay film frame according to claim 1, is characterized in that described anti-proliferative drug is any one in the derivant of paclitaxel, rapamycin and two kinds of medicines, or two or more the mixing in them.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510768484.9A CN105250048A (en) | 2015-11-12 | 2015-11-12 | Coronary artery covered stent |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510768484.9A CN105250048A (en) | 2015-11-12 | 2015-11-12 | Coronary artery covered stent |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN105250048A true CN105250048A (en) | 2016-01-20 |
Family
ID=55090206
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201510768484.9A Pending CN105250048A (en) | 2015-11-12 | 2015-11-12 | Coronary artery covered stent |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN105250048A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107510519A (en) * | 2017-09-05 | 2017-12-26 | 辽宁垠艺生物科技股份有限公司 | Band film network |
Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20060161242A1 (en) * | 2005-01-17 | 2006-07-20 | Lee Kyung B | Multilayer-coated stent for controlled drug release and manufacturing method thereof |
| CN2920186Y (en) * | 2006-06-01 | 2007-07-11 | 天津市凯迪亚医疗器械有限公司 | Coronary stent |
| CN101385669A (en) * | 2007-09-12 | 2009-03-18 | 中国科学院金属研究所 | Anti-coagulation stainless steel coronary arterial bracket and uses thereof |
| CN101632606A (en) * | 2008-07-21 | 2010-01-27 | 微创医疗器械(上海)有限公司 | Interventional medical device carrying medicaments |
| CN101810889A (en) * | 2010-04-16 | 2010-08-25 | 上海交通大学 | Internal lumen inner bracket with bilateral medicine-releasing performance and preparation method thereof |
| CN102579097A (en) * | 2012-02-15 | 2012-07-18 | 北京航空航天大学 | Film-covered stent |
| CN205144807U (en) * | 2015-11-12 | 2016-04-13 | 辽宁垠艺生物科技股份有限公司 | Coronary tectorial membrane support |
-
2015
- 2015-11-12 CN CN201510768484.9A patent/CN105250048A/en active Pending
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20060161242A1 (en) * | 2005-01-17 | 2006-07-20 | Lee Kyung B | Multilayer-coated stent for controlled drug release and manufacturing method thereof |
| CN2920186Y (en) * | 2006-06-01 | 2007-07-11 | 天津市凯迪亚医疗器械有限公司 | Coronary stent |
| CN101385669A (en) * | 2007-09-12 | 2009-03-18 | 中国科学院金属研究所 | Anti-coagulation stainless steel coronary arterial bracket and uses thereof |
| CN101632606A (en) * | 2008-07-21 | 2010-01-27 | 微创医疗器械(上海)有限公司 | Interventional medical device carrying medicaments |
| CN101810889A (en) * | 2010-04-16 | 2010-08-25 | 上海交通大学 | Internal lumen inner bracket with bilateral medicine-releasing performance and preparation method thereof |
| CN102579097A (en) * | 2012-02-15 | 2012-07-18 | 北京航空航天大学 | Film-covered stent |
| CN205144807U (en) * | 2015-11-12 | 2016-04-13 | 辽宁垠艺生物科技股份有限公司 | Coronary tectorial membrane support |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107510519A (en) * | 2017-09-05 | 2017-12-26 | 辽宁垠艺生物科技股份有限公司 | Band film network |
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Application publication date: 20160120 |