CN104892668A - 考布他汀类似物水溶性前-前药及其制备方法 - Google Patents

考布他汀类似物水溶性前-前药及其制备方法 Download PDF

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Publication number: CN104892668A
Authority: CN; China
Prior art keywords: reaction; prodrug; dimethylphenyl; structural formula; add
Prior art date: 2015-05-12
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Granted

Application number

CN201510241243.9A

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English (en)

Chinese (zh)

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CN104892668B (zh

Inventor

鲍治成

沈卫平

卜海冬

王军福

于静

方栋

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

University of Shanghai for Science and Technology

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University of Shanghai for Science and Technology

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2015-05-12

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2015-05-12

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2015-09-09

2015-05-12 Application filed by University of Shanghai for Science and Technology filed Critical University of Shanghai for Science and Technology

2015-05-12 Priority to CN201510241243.9A priority Critical patent/CN104892668B/zh

2015-09-09 Publication of CN104892668A publication Critical patent/CN104892668A/zh

2017-03-29 Application granted granted Critical

2017-03-29 Publication of CN104892668B publication Critical patent/CN104892668B/zh

Status Active legal-status Critical Current

2035-05-12 Anticipated expiration legal-status Critical

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0 CC(C)(CC(Nc(cc(C=Cc(cc1OC)cc(OC)c1OC)cc1)c1OC)=O)c(c(C)cc(C)c1)c1OP(*)(O)=O Chemical compound CC(C)(CC(Nc(cc(C=Cc(cc1OC)cc(OC)c1OC)cc1)c1OC)=O)c(c(C)cc(C)c1)c1OP(*)(O)=O 0.000 description 1

CN201510241243.9A 2015-05-12 2015-05-12 考布他汀类似物水溶性前‑前药及其制备方法 Active CN104892668B (zh)

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CN201510241243.9A CN104892668B (zh)	2015-05-12	2015-05-12	考布他汀类似物水溶性前‑前药及其制备方法

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CN108607605A (zh) *	2018-06-11	2018-10-02	徐州得铸生物科技有限公司	一种用于合成异戊烯酸甲酯的催化剂
CN112898128A (zh) *	2021-02-08	2021-06-04	苏州华道生物药业股份有限公司	红褐林蚁信息素成分3-乙基-4-甲基戊醇的合成方法

Citations (5)

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Publication number	Priority date	Publication date	Assignee	Title
US5561122A (en) *	1994-12-22	1996-10-01	Arizona Board Of Regents Acting On Behalf Of Arizona State University	Combretastatin A-4 prodrug
WO2002006279A1 (en) *	2000-07-17	2002-01-24	Oxigene Inc	Efficient method of synthesizing combretastatin a-4 prodrugs
US20030220304A1 (en) *	2000-04-27	2003-11-27	Pettit George R.	Hydroxyphenstatin and the prodrugs thereof
CN101220054A (zh) *	2008-01-29	2008-07-16	成都恒基医药科技有限公司	康普瑞汀a-4磷酸酯二钠盐的制备方法
CN102015620A (zh) *	2008-02-28	2011-04-13	赛诺菲-安万特	制备考布他汀的方法

2015
- 2015-05-12 CN CN201510241243.9A patent/CN104892668B/zh active Active

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5561122A (en) *	1994-12-22	1996-10-01	Arizona Board Of Regents Acting On Behalf Of Arizona State University	Combretastatin A-4 prodrug
US20030220304A1 (en) *	2000-04-27	2003-11-27	Pettit George R.	Hydroxyphenstatin and the prodrugs thereof
WO2002006279A1 (en) *	2000-07-17	2002-01-24	Oxigene Inc	Efficient method of synthesizing combretastatin a-4 prodrugs
CN101220054A (zh) *	2008-01-29	2008-07-16	成都恒基医药科技有限公司	康普瑞汀a-4磷酸酯二钠盐的制备方法
CN102015620A (zh) *	2008-02-28	2011-04-13	赛诺菲-安万特	制备考布他汀的方法

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
R.BROWN ET AL.: "Carbon-14 radiosynthesis of combretastatinA-1 (CA1) and its corresponding phosphate prodrug (CA1P)", 《J. LABEL COMPD. RADIOPHARM》 *
夏虎雄等: "考布他汀4A 磷酸酯缓释纳米粒的制备及抗肿瘤活性考察", 《中国实验方剂学杂志》 *

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CN108607605A (zh) *	2018-06-11	2018-10-02	徐州得铸生物科技有限公司	一种用于合成异戊烯酸甲酯的催化剂
CN112898128A (zh) *	2021-02-08	2021-06-04	苏州华道生物药业股份有限公司	红褐林蚁信息素成分3-乙基-4-甲基戊醇的合成方法
CN112898128B (zh) *	2021-02-08	2023-07-07	苏州华道生物药业股份有限公司	红褐林蚁信息素成分3-乙基-4-甲基戊醇的合成方法

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