CN104447598B - Ca‑4的大环多胺衍生物及其抗肿瘤特性 - Google Patents

Ca‑4的大环多胺衍生物及其抗肿瘤特性 Download PDF

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CN104447598B
CN104447598B CN201310428519.5A CN201310428519A CN104447598B CN 104447598 B CN104447598 B CN 104447598B CN 201310428519 A CN201310428519 A CN 201310428519A CN 104447598 B CN104447598 B CN 104447598B
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compound
cancer
group
metal ion
anion
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CN104447598A (zh
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王建平
王建国
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Zhejiang Dade Pharmaceutical Group Co Ltd
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Zhejiang Dade Pharmaceutical Group Co Ltd
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D255/00—Heterocyclic compounds containing rings having three nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D249/00 - C07D253/00
    • C07D255/02—Heterocyclic compounds containing rings having three nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D249/00 - C07D253/00 not condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6524—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having four or more nitrogen atoms as the only ring hetero atoms
CN201310428519.5A 2013-09-18 2013-09-18 Ca‑4的大环多胺衍生物及其抗肿瘤特性 Active CN104447598B (zh)

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Families Citing this family (5)

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JP7421790B2 (ja) 2016-09-19 2024-01-25 ザ ホンコン ポリテクニック ユニヴァーシティー キラルなサイクレン化合物およびその使用
CN108264491B (zh) * 2016-12-30 2022-09-16 威智医药有限公司 1,4,7,10-四氮杂环十二烷-1,4,7,10-四乙酸的制备方法
FR3092580B1 (fr) * 2019-02-08 2021-03-19 Centre Nat Rech Scient Nouveaux dérivés azobenzènes, leur procédé de préparation et leur utilisation pour le traitement thérapeutique associé à des radiations ionisantes
CN112225673B (zh) * 2020-11-13 2022-08-02 义乌市华耀医药科技有限公司 氨基康普立停衍生物及其应用
CN115403483B (zh) * 2021-07-02 2024-01-26 河南省儿童医院郑州儿童医院 含二苯乙烯或二苯甲酮骨架的ca-4衍生物、药物组合物及其制备方法和应用

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1465580A (zh) * 2002-06-07 2004-01-07 深圳市北大高科技股份有限公司 一种简便合成康普立停a-4前药的方法
CN101085743A (zh) * 2006-06-06 2007-12-12 浙江大德药业集团有限公司 含氟烷氧基康普立停衍生物及制法和用途
CN101139358A (zh) * 2006-09-07 2008-03-12 浙江大德药业集团有限公司 乙氧基康普立停及其前药的制备和用途
CN103012248A (zh) * 2013-01-11 2013-04-03 浙江大德药业集团有限公司 氨基康普立停衍生物的合成及其作为口服抗肿瘤药物的应用

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050153939A1 (en) * 2003-09-10 2005-07-14 Bristol-Myers Squibb Company Combretastatin A-4 phosphate prodrug mono-and di-organic amine salts, mono-and di-amino acid salts, and mono-and di-amino acid ester salts
FR2928148B1 (fr) * 2008-02-28 2013-01-18 Sanofi Aventis Procede de preparation de combretastatine

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1465580A (zh) * 2002-06-07 2004-01-07 深圳市北大高科技股份有限公司 一种简便合成康普立停a-4前药的方法
CN101085743A (zh) * 2006-06-06 2007-12-12 浙江大德药业集团有限公司 含氟烷氧基康普立停衍生物及制法和用途
CN101139358A (zh) * 2006-09-07 2008-03-12 浙江大德药业集团有限公司 乙氧基康普立停及其前药的制备和用途
CN103012248A (zh) * 2013-01-11 2013-04-03 浙江大德药业集团有限公司 氨基康普立停衍生物的合成及其作为口服抗肿瘤药物的应用

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Denomination of invention: Macrocyclic polyamine derivatives of CA-4 and their antitumor properties

Effective date of registration: 20220110

Granted publication date: 20170922

Pledgee: Zhejiang Yiwu Rural Commercial Bank Co.,Ltd.

Pledgor: ZHEJIANG DADE PHARMACEUTICAL GROUP Co.,Ltd.

Registration number: Y2022330000037

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Date of cancellation: 20230104

Granted publication date: 20170922

Pledgee: Zhejiang Yiwu Rural Commercial Bank Co.,Ltd.

Pledgor: ZHEJIANG DADE PHARMACEUTICAL GROUP Co.,Ltd.

Registration number: Y2022330000037